| 1990-04-10 | vs PHI | 1 | W 2-1 | 1-0 | 1 | 7,791 | Mike Bielecki | Bruce Ruffin | Les Lancaster | Jeff Parrett | Mitch Williams | 2 | 1 | 1 |
| 1990-04-12 | vs PHI | 2 | L 4-5 | 2-1 | 1 | 0 | Steve Wilson | Terry Mulholland | Terry Mulholland | Steve Wilson | Roger McDowell | 6 | 6 | 0 |
| 1990-04-12 | vs PHI | 3 | W 6-3 | 2-1 | 1 | 7,717 | Jose Nunez | Pat Combs | Jose Nunez | Pat Combs | Mitch Williams | 12 | 9 | 3 |
| 1990-04-13 | @ PIT | 4 | W 2-0 | 3-1 | 1 | 44,799 | Greg Maddux | Bob Walk | Greg Maddux | Bob Walk | Mitch Williams | 14 | 9 | 5 |
| 1990-04-14 | @ PIT | 5 | W 4-1 | 4-1 | 1 | 13,226 | Mike Harkey | Doug Drabek | Mike Harkey | Doug Drabek | Mitch Williams | 18 | 10 | 8 |
| 1990-04-15 | @ PIT | 6 | L 3-4 | 4-2 | 1 | 6,289 | Mike Bielecki | Walt Terrell | Bob Patterson | Les Lancaster | | 21 | 14 | 7 |
| 1990-04-16 | vs NYN | 7 | L 1-10 | 4-3 | 1 | 13,813 | Steve Wilson | Frank Viola | Frank Viola | Steve Wilson | Alejandro Pena | 22 | 24 | -2 |
| 1990-04-17 | @ NYN | 8 | W 8-6 | 5-3 | 1 | 13,964 | Jose Nunez | Sid Fernandez | Paul Assenmacher | Jeff Innis | Dean Wilkins | 30 | 30 | 0 |
| 1990-04-18 | @ NYN | 9 | W 8-5 | 6-3 | 1 | 21,561 | Greg Maddux | David Cone | Greg Maddux | David Cone | | 38 | 35 | 3 |
| 1990-04-19 | @ NYN | 10 | L 1-4 | 6-4 | 1 | 18,780 | Mike Harkey | Dwight Gooden | Dwight Gooden | Mike Harkey | John Franco | 39 | 39 | 0 |
| 1990-04-20 | vs PIT | 11 | L 4-9 | 6-5 | 2 | 15,171 | Mike Bielecki | Walt Terrell | Mike Roesler | Mike Bielecki | | 43 | 48 | -5 |
| 1990-04-21 | vs PIT | 12 | L 3-4 | 6-6 | 3 | 37,091 | Steve Wilson | John Smiley | John Smiley | Steve Wilson | Bill Landrum | 46 | 52 | -6 |
| 1990-04-22 | vs PIT | 13 | L 2-3 | 6-7 | 4 | 33,583 | Jose Nunez | Neal Heaton | Neal Heaton | Jose Nunez | Ted Power | 48 | 55 | -7 |
| 1990-04-24 | @ SDN | 14 | L 3-13 | 6-8 | 5 | 19,474 | Greg Maddux | Dennis Rasmussen | Dennis Rasmussen | Greg Maddux | | 51 | 68 | -17 |
| 1990-04-25 | @ SDN | 15 | L 0-3 | 6-9 | 6 | 22,305 | Mike Bielecki | Ed Whitson | Ed Whitson | Mike Bielecki | | 51 | 71 | -20 |
| 1990-04-26 | @ SDN | 16 | W 3-1 | 7-9 | 6 | 29,168 | Mike Harkey | Bruce Hurst | Mike Harkey | Bruce Hurst | Mitch Williams | 54 | 72 | -18 |
| 1990-04-27 | @ LAN | 17 | L 0-5 | 7-10 | 6 | 37,809 | Jose Nunez | Fernando Valenzuela | Fernando Valenzuela | Jose Nunez | | 54 | 77 | -23 |
| 1990-04-28 | @ LAN | 18 | L 4-5 | 7-11 | 6 | 45,791 | Steve Wilson | Ramon Martinez | Ramon Martinez | Mitch Williams | | 58 | 82 | -24 |
| 1990-04-29 | @ LAN | 19 | W 4-0 | 8-11 | 6 | 41,893 | Greg Maddux | Mike Morgan | Greg Maddux | Mike Morgan | | 62 | 82 | -20 |
| 1990-05-01 | @ SFN | 20 | W 7-4 | 9-11 | 5 | 21,714 | Mike Bielecki | Atlee Hammaker | Mike Bielecki | Bob Knepper | Mitch Williams | 69 | 86 | -17 |
| 1990-05-02 | @ SFN | 21 | W 9-6 | 10-11 | 4 | 18,279 | Mike Harkey | Scott Garrelts | Mike Harkey | Scott Garrelts | Paul Assenmacher | 78 | 92 | -14 |
| 1990-05-05 | vs SDN | 22 | W 3-2 | 11-12 | 4 | 0 | Greg Maddux | Andy Benes | Greg Maddux | Craig Lefferts | | 81 | 94 | -13 |
| 1990-05-05 | vs SDN | 23 | L 5-6 | 11-12 | 4 | 33,695 | Jose Nunez | Dennis Rasmussen | Dennis Rasmussen | Jose Nunez | Greg Harris | 86 | 100 | -14 |
| 1990-05-06 | vs SDN | 24 | L 3-8 | 11-13 | 5 | 34,077 | Mike Bielecki | Ed Whitson | Ed Whitson | Mike Bielecki | | 89 | 108 | -19 |
| 1990-05-07 | vs ATL | 25 | L 8-9 | 11-14 | 5 | 32,266 | Mike Harkey | Marty Clary | Charlie Kerfeld | Mitch Williams | Joe Boever | 97 | 117 | -20 |
| 1990-05-08 | vs ATL | 26 | W 10-8 | 12-14 | 5 | 18,503 | Steve Wilson | Tom Glavine | Bill Long | Dwayne Henry | | 107 | 125 | -18 |
| 1990-05-09 | vs ATL | 27 | W 4-0 | 13-14 | 5 | 14,266 | Les Lancaster | Pete Smith | Les Lancaster | Pete Smith | | 111 | 125 | -14 |
| 1990-05-11 | @ CIN | 28 | L 5-7 | 13-15 | 5 | 38,900 | Greg Maddux | Scott Scudder | Norm Charlton | Mitch Williams | Rob Dibble | 116 | 132 | -16 |
| 1990-05-12 | @ CIN | 29 | W 4-2 | 14-15 | 5 | 33,646 | Mike Bielecki | Tom Browning | Mike Bielecki | Tom Browning | Mitch Williams | 120 | 134 | -14 |
| 1990-05-13 | @ CIN | 30 | L 9-13 | 14-16 | 5 | 32,251 | Mike Harkey | Ron Robinson | Rob Dibble | Steve Wilson | | 129 | 147 | -18 |
| 1990-05-14 | @ ATL | 31 | L 2-3 | 14-17 | 5 | 16,417 | Les Lancaster | Tom Glavine | Dwayne Henry | Mitch Williams | Charlie Kerfeld | 131 | 150 | -19 |
| 1990-05-15 | @ ATL | 32 | W 12-2 | 15-17 | 5 | 16,271 | Jeff Pico | Pete Smith | Jeff Pico | Pete Smith | | 143 | 152 | -9 |
| 1990-05-16 | @ ATL | 33 | L 0-4 | 15-18 | 5 | 13,345 | Greg Maddux | John Smoltz | John Smoltz | Greg Maddux | | 143 | 156 | -13 |
| 1990-05-17 | @ HOU | 34 | L 4-5 | 15-19 | 6 | 14,644 | Mike Bielecki | Mark Portugal | Dave Smith | Jose Nunez | | 147 | 161 | -14 |
| 1990-05-18 | @ HOU | 35 | W 7-0 | 16-19 | 5 | 22,972 | Mike Harkey | Bill Gullickson | Mike Harkey | Bill Gullickson | | 154 | 161 | -7 |
| 1990-05-19 | @ HOU | 36 | W 4-1 | 17-19 | 5 | 32,253 | Les Lancaster | Jim Clancy | Les Lancaster | Jim Clancy | Mitch Williams | 158 | 162 | -4 |
| 1990-05-20 | @ HOU | 37 | W 5-1 | 18-19 | 4 | 26,451 | Shawn Boskie | Mike Scott | Shawn Boskie | Mike Scott | | 163 | 163 | 0 |
| 1990-05-21 | vs CIN | 38 | L 3-4 | 18-20 | 5 | 31,476 | Greg Maddux | Jose Rijo | Jose Rijo | Greg Maddux | Randy Myers | 166 | 167 | -1 |
| 1990-05-22 | vs CIN | 39 | W 2-1 | 19-20 | 5 | 29,860 | Mike Bielecki | Tom Browning | Bill Long | Scott Scudder | | 168 | 168 | 0 |
| 1990-05-23 | vs LAN | 40 | L 3-4 | 19-21 | 5 | 23,963 | Mike Harkey | Tim Belcher | Tim Belcher | Paul Assenmacher | Don Aase | 171 | 172 | -1 |
| 1990-05-24 | vs LAN | 41 | L 6-15 | 19-22 | 5 | 27,918 | Les Lancaster | Fernando Valenzuela | Fernando Valenzuela | Les Lancaster | | 177 | 187 | -10 |
| 1990-05-26 | vs HOU | 42 | L 1-8 | 19-24 | 5 | 0 | Shawn Boskie | Mike Scott | Mike Scott | Shawn Boskie | | 178 | 195 | -17 |
| 1990-05-26 | vs HOU | 43 | L 3-12 | 19-24 | 5 | 31,995 | Greg Maddux | Jim Deshaies | Jim Deshaies | Greg Maddux | Larry Andersen | 181 | 207 | -26 |
| 1990-05-27 | vs HOU | 44 | W 11-6 | 20-24 | 5 | 36,395 | Mike Bielecki | Mark Portugal | Mike Bielecki | Mark Portugal | | 192 | 213 | -21 |
| 1990-05-28 | vs SFN | 45 | W 5-1 | 21-24 | 5 | 33,822 | Mike Harkey | Bob Knepper | Mike Harkey | Bob Knepper | Les Lancaster | 197 | 214 | -17 |
| 1990-05-29 | vs SFN | 46 | L 2-6 | 21-25 | 5 | 28,925 | Kevin Blankenship | Don Robinson | Don Robinson | Kevin Blankenship | Jeff Brantley | 199 | 220 | -21 |
| 1990-05-30 | vs SFN | 47 | L 1-4 | 21-26 | 5 | 29,109 | Shawn Boskie | John Burkett | John Burkett | Shawn Boskie | Steve Bedrosian | 200 | 224 | -24 |
| 1990-06-01 | @ SLN | 48 | L 4-6 | 21-27 | 5 | 43,773 | Greg Maddux | Jose DeLeon | Jose DeLeon | Greg Maddux | Lee Smith | 204 | 230 | -26 |
| 1990-06-02 | @ SLN | 49 | W 7-6 | 22-27 | 5 | 48,051 | Mike Bielecki | Greg Mathews | Les Lancaster | Lee Smith | Mitch Williams | 211 | 236 | -25 |
| 1990-06-03 | @ SLN | 50 | L 4-7 | 22-28 | 5 | 45,393 | Kevin Blankenship | Bryn Smith | Bryn Smith | Kevin Blankenship | | 215 | 243 | -28 |
| 1990-06-04 | @ PIT | 51 | L 2-6 | 22-29 | 6 | 9,257 | Shawn Boskie | Bob Patterson | Bob Patterson | Shawn Boskie | Bill Landrum | 217 | 249 | -32 |
| 1990-06-05 | @ PIT | 52 | L 5-6 | 22-30 | 6 | 20,642 | Paul Assenmacher | Walt Terrell | Stan Belinda | Mitch Williams | | 222 | 255 | -33 |
| 1990-06-06 | @ PIT | 53 | L 1-6 | 22-31 | 6 | 21,164 | Greg Maddux | Doug Drabek | Doug Drabek | Greg Maddux | | 223 | 261 | -38 |
| 1990-06-07 | vs PHI | 54 | L 1-3 | 22-32 | 6 | 29,271 | Mike Bielecki | Ken Howell | Ken Howell | Mike Bielecki | | 224 | 264 | -40 |
| 1990-06-08 | vs PHI | 55 | W 15-2 | 23-32 | 6 | 32,219 | Jeff Pico | Terry Mulholland | Jeff Pico | Terry Mulholland | | 239 | 266 | -27 |
| 1990-06-09 | vs PHI | 56 | W 4-3 | 24-32 | 5 | 33,266 | Shawn Boskie | Marvin Freeman | Les Lancaster | Jeff Parrett | | 243 | 269 | -26 |
| 1990-06-10 | vs PHI | 57 | W 7-3 | 25-32 | 5 | 32,187 | Steve Wilson | Bruce Ruffin | Steve Wilson | Bruce Ruffin | Les Lancaster | 250 | 272 | -22 |
| 1990-06-11 | vs NYN | 58 | W 8-5 | 26-32 | 5 | 33,059 | Greg Maddux | Frank Viola | Mitch Williams | Alejandro Pena | Paul Assenmacher | 258 | 277 | -19 |
| 1990-06-12 | vs NYN | 59 | L 8-19 | 26-33 | 5 | 34,893 | Mike Bielecki | Dwight Gooden | Dwight Gooden | Mike Bielecki | | 266 | 296 | -30 |
| 1990-06-13 | vs NYN | 60 | L 10-15 | 26-35 | 5 | 0 | Jeff Pico | Sid Fernandez | John Franco | Les Lancaster | | 276 | 311 | -35 |
| 1990-06-13 | vs NYN | 61 | L 6-9 | 26-35 | 5 | 34,241 | Mike Harkey | Ron Darling | Ron Darling | Mike Harkey | | 282 | 320 | -38 |
| 1990-06-15 | @ PHI | 62 | L 5-6 | 26-37 | 5 | 0 | Steve Wilson | Pat Combs | Darrel Akerfelds | Jose Nunez | | 287 | 326 | -39 |
| 1990-06-15 | @ PHI | 63 | L 0-7 | 26-37 | 5 | 26,098 | Mike Bielecki | Bruce Ruffin | Bruce Ruffin | Mike Bielecki | | 287 | 333 | -46 |
| 1990-06-16 | @ PHI | 64 | L 1-2 | 26-38 | 6 | 32,023 | Greg Maddux | Dennis Cook | Darrel Akerfelds | Greg Maddux | | 288 | 335 | -47 |
| 1990-06-17 | @ PHI | 65 | W 5-3 | 27-38 | 6 | 30,338 | Jeff Pico | Ken Howell | Jeff Pico | Jeff Parrett | Les Lancaster | 293 | 338 | -45 |
| 1990-06-18 | @ MON | 66 | L 1-5 | 27-39 | 6 | 15,898 | Mike Harkey | Dennis Martinez | Dennis Martinez | Mike Harkey | | 294 | 343 | -49 |
| 1990-06-19 | @ MON | 67 | W 2-1 | 28-39 | 5 | 20,306 | Shawn Boskie | Mark Gardner | Shawn Boskie | Mark Gardner | Les Lancaster | 296 | 344 | -48 |
| 1990-06-20 | @ MON | 68 | L 2-3 | 28-40 | 5 | 22,058 | Greg Maddux | Oil Can Boyd | Dale Mohorcic | Greg Maddux | Dave J. Schmidt | 298 | 347 | -49 |
| 1990-06-22 | vs SLN | 69 | L 0-7 | 28-41 | 6 | 30,764 | Steve Wilson | Joe Magrane | Joe Magrane | Steve Wilson | | 298 | 354 | -56 |
| 1990-06-23 | vs SLN | 70 | L 7-8 | 28-42 | 6 | 33,721 | Mike Bielecki | Bob Tewksbury | Bob Tewksbury | Mike Bielecki | Lee Smith | 305 | 362 | -57 |
| 1990-06-24 | vs SLN | 71 | W 3-2 | 29-42 | 6 | 34,229 | Mike Harkey | Jose DeLeon | Paul Assenmacher | Tom Niedenfuer | | 308 | 364 | -56 |
| 1990-06-25 | vs MON | 72 | L 3-7 | 29-43 | 6 | 32,231 | Shawn Boskie | Mark Gardner | Mark Gardner | Shawn Boskie | Bill Sampen | 311 | 371 | -60 |
| 1990-06-26 | vs MON | 73 | L 5-6 | 29-44 | 6 | 31,676 | Greg Maddux | Oil Can Boyd | Dave J. Schmidt | Les Lancaster | Steve Frey | 316 | 377 | -61 |
| 1990-06-27 | vs MON | 74 | W 5-3 | 30-44 | 5 | 32,830 | Jeff Pico | Kevin Gross | Jeff Pico | Kevin Gross | Steve Wilson | 321 | 380 | -59 |
| 1990-06-28 | vs MON | 75 | W 3-2 | 31-44 | 5 | 31,974 | Mike Bielecki | Zane Smith | Les Lancaster | Bill Sampen | | 324 | 382 | -58 |
| 1990-06-29 | @ SDN | 76 | W 3-2 | 32-44 | 5 | 43,005 | Mike Harkey | Mike Dunne | Bill Long | Greg Harris | Paul Assenmacher | 327 | 384 | -57 |
| 1990-06-30 | @ SDN | 77 | W 7-3 | 33-44 | 5 | 31,852 | Shawn Boskie | Andy Benes | Steve Wilson | Andy Benes | | 334 | 387 | -53 |
| 1990-07-01 | @ SDN | 78 | W 11-10 | 34-44 | 5 | 30,968 | Greg Maddux | Dennis Rasmussen | Les Lancaster | Craig Lefferts | Bill Long | 345 | 397 | -52 |
| 1990-07-02 | @ LAN | 79 | L 1-3 | 34-45 | 5 | 32,600 | Jeff Pico | Tim Belcher | Tim Belcher | Jeff Pico | | 346 | 400 | -54 |
| 1990-07-03 | @ LAN | 80 | L 6-7 | 34-46 | 5 | 40,235 | Mike Bielecki | Terry Wells | Mike Hartley | Paul Assenmacher | | 352 | 407 | -55 |
| 1990-07-04 | @ LAN | 81 | W 5-3 | 35-46 | 5 | 46,811 | Mike Harkey | Fernando Valenzuela | Mike Harkey | Fernando Valenzuela | Les Lancaster | 357 | 410 | -53 |
| 1990-07-06 | @ SFN | 82 | W 5-2 | 36-46 | 5 | 28,517 | Shawn Boskie | Scott Garrelts | Shawn Boskie | Scott Garrelts | Bill Long | 362 | 412 | -50 |
| 1990-07-07 | @ SFN | 83 | L 9-10 | 36-47 | 5 | 36,005 | Greg Maddux | Don Robinson | Jeff Brantley | Les Lancaster | | 371 | 422 | -51 |
| 1990-07-08 | @ SFN | 84 | L 3-5 | 36-49 | 5 | 0 | Jeff Pico | Trevor Wilson | Trevor Wilson | Jeff Pico | Jeff Brantley | 374 | 427 | -53 |
| 1990-07-08 | @ SFN | 85 | L 4-10 | 36-49 | 5 | 45,669 | Mike Bielecki | John Burkett | John Burkett | Mike Bielecki | | 378 | 437 | -59 |
| 1990-07-12 | vs LAN | 86 | L 3-6 | 36-50 | 5 | 31,518 | Mike Harkey | Fernando Valenzuela | Fernando Valenzuela | Mike Harkey | Jay Howell | 381 | 443 | -62 |
| 1990-07-13 | vs LAN | 87 | L 2-5 | 36-51 | 5 | 31,438 | Shawn Boskie | Ramon Martinez | Ramon Martinez | Shawn Boskie | Jay Howell | 383 | 448 | -65 |
| 1990-07-14 | vs LAN | 88 | L 0-7 | 36-52 | 6 | 31,919 | Greg Maddux | Mike Morgan | Mike Morgan | Greg Maddux | | 383 | 455 | -72 |
| 1990-07-15 | vs LAN | 89 | W 5-1 | 37-52 | 5 | 29,266 | Steve Wilson | Tim Belcher | Steve Wilson | Tim Belcher | | 388 | 456 | -68 |
| 1990-07-16 | vs SDN | 90 | W 4-3 | 38-52 | 5 | 31,523 | Mike Harkey | Eric Show | Mike Harkey | Eric Show | Mitch Williams | 392 | 459 | -67 |
| 1990-07-17 | vs SDN | 91 | W 7-2 | 39-52 | 5 | 32,923 | Shawn Boskie | Andy Benes | Shawn Boskie | Andy Benes | | 399 | 461 | -62 |
| 1990-07-18 | vs SDN | 92 | W 4-2 | 40-52 | 5 | 33,856 | Greg Maddux | Dennis Rasmussen | Greg Maddux | Dennis Rasmussen | Jeff Pico | 403 | 463 | -60 |
| 1990-07-20 | vs SFN | 93 | W 5-4 | 41-52 | 5 | 30,532 | Steve Wilson | John Burkett | Mike Bielecki | Jeff Brantley | | 408 | 467 | -59 |
| 1990-07-21 | vs SFN | 94 | W 3-2 | 42-52 | 5 | 34,463 | Mike Harkey | Scott Garrelts | Mike Harkey | Jeff Brantley | | 411 | 469 | -58 |
| 1990-07-22 | vs SFN | 95 | W 4-2 | 43-52 | 5 | 33,708 | Shawn Boskie | Don Robinson | Paul Assenmacher | Atlee Hammaker | Jeff Pico | 415 | 471 | -56 |
| 1990-07-23 | @ SLN | 96 | W 3-1 | 44-52 | 5 | 40,534 | Greg Maddux | Jose DeLeon | Greg Maddux | Jose DeLeon | Mitch Williams | 418 | 472 | -54 |
| 1990-07-24 | @ SLN | 97 | L 4-9 | 44-53 | 5 | 38,974 | Steve Wilson | Joe Magrane | Scott Terry | Steve Wilson | | 422 | 481 | -59 |
| 1990-07-25 | @ SLN | 98 | L 0-9 | 44-54 | 5 | 37,826 | Mike Harkey | John Tudor | John Tudor | Mike Harkey | | 422 | 490 | -68 |
| 1990-07-26 | @ MON | 99 | L 2-3 | 44-55 | 5 | 19,129 | Shawn Boskie | Oil Can Boyd | Tim Burke | Mitch Williams | | 424 | 493 | -69 |
| 1990-07-27 | @ MON | 100 | W 2-0 | 45-55 | 5 | 21,980 | Greg Maddux | Mark Gardner | Greg Maddux | Bill Sampen | Bill Long | 426 | 493 | -67 |
| 1990-07-28 | @ MON | 101 | W 10-7 | 46-55 | 5 | 24,808 | Mike Bielecki | Dennis Martinez | Bill Long | Tim Burke | | 436 | 500 | -64 |
| 1990-07-29 | @ MON | 102 | W 2-1 | 47-55 | 5 | 24,333 | Mike Harkey | Kevin Gross | Mike Harkey | Kevin Gross | Mitch Williams | 438 | 501 | -63 |
| 1990-07-31 | vs PIT | 103 | L 1-9 | 47-56 | 5 | 35,126 | Shawn Boskie | Bob Walk | Bob Patterson | Shawn Boskie | | 439 | 510 | -71 |
| 1990-08-01 | vs PIT | 104 | W 5-0 | 48-56 | 5 | 34,542 | Greg Maddux | Rick Reed | Greg Maddux | Rick Reed | | 444 | 510 | -66 |
| 1990-08-02 | vs PIT | 105 | L 5-8 | 48-57 | 5 | 34,493 | Steve Wilson | John Smiley | John Smiley | Steve Wilson | Bob Walk | 449 | 518 | -69 |
| 1990-08-03 | vs MON | 106 | W 10-4 | 49-57 | 5 | 33,318 | Mike Harkey | Mark Gardner | Mike Harkey | Mark Gardner | | 459 | 522 | -63 |
| 1990-08-04 | vs MON | 107 | W 10-2 | 50-57 | 5 | 35,176 | Shawn Boskie | Kevin Gross | Shawn Boskie | Kevin Gross | | 469 | 524 | -55 |
| 1990-08-05 | vs MON | 108 | W 3-1 | 51-57 | 5 | 33,481 | Greg Maddux | Oil Can Boyd | Greg Maddux | Oil Can Boyd | | 472 | 525 | -53 |
| 1990-08-07 | vs SLN | 109 | W 5-3 | 52-57 | 5 | 34,271 | Mike Bielecki | Bob Tewksbury | Paul Assenmacher | Scott Terry | Mitch Williams | 477 | 528 | -51 |
| 1990-08-08 | vs SLN | 110 | W 4-3 | 53-57 | 4 | 34,977 | Mike Harkey | Jose DeLeon | Bill Long | Tom Niedenfuer | | 481 | 531 | -50 |
| 1990-08-09 | vs SLN | 111 | L 1-3 | 53-58 | 4 | 36,328 | Lance Dickson | Ken Hill | Ken Hill | Lance Dickson | Lee Smith | 482 | 534 | -52 |
| 1990-08-10 | @ NYN | 112 | L 1-5 | 53-59 | 4 | 34,090 | Greg Maddux | Sid Fernandez | Sid Fernandez | Greg Maddux | | 483 | 539 | -56 |
| 1990-08-11 | @ NYN | 113 | W 6-3 | 54-59 | 4 | 45,710 | Mike Bielecki | Ron Darling | Steve Wilson | Ron Darling | Paul Assenmacher | 489 | 542 | -53 |
| 1990-08-12 | @ NYN | 114 | W 10-2 | 55-59 | 4 | 46,538 | Mike Harkey | Frank Viola | Mike Harkey | Frank Viola | | 499 | 544 | -45 |
| 1990-08-13 | vs HOU | 115 | L 2-7 | 55-60 | 4 | 34,087 | Lance Dickson | Mark Portugal | Mark Portugal | Lance Dickson | | 501 | 551 | -50 |
| 1990-08-14 | vs HOU | 116 | W 5-2 | 56-60 | 4 | 34,843 | Greg Maddux | Mike Scott | Greg Maddux | Mike Scott | Bill Long | 506 | 553 | -47 |
| 1990-08-15 | vs HOU | 117 | L 4-8 | 56-61 | 4 | 34,307 | Mike Bielecki | Jim Deshaies | Dave Smith | Jeff Pico | | 510 | 561 | -51 |
| 1990-08-17 | vs ATL | 118 | W 7-0 | 57-61 | 4 | 29,893 | Mike Harkey | John Smoltz | Mike Harkey | John Smoltz | | 517 | 561 | -44 |
| 1990-08-18 | vs ATL | 119 | L 6-17 | 57-62 | 4 | 36,226 | Lance Dickson | Charlie Leibrandt | Charlie Leibrandt | Lance Dickson | | 523 | 578 | -55 |
| 1990-08-19 | vs ATL | 120 | W 5-4 | 58-62 | 4 | 33,284 | Greg Maddux | Steve Avery | Greg Maddux | Kent Mercker | Paul Assenmacher | 528 | 582 | -54 |
| 1990-08-20 | @ CIN | 121 | W 3-1 | 59-62 | 4 | 26,011 | Mike Bielecki | Norm Charlton | Mike Bielecki | Norm Charlton | Bill Long | 531 | 583 | -52 |
| 1990-08-21 | @ CIN | 122 | L 1-8 | 59-63 | 4 | 22,759 | Mike Harkey | Rick Mahler | Rick Mahler | Mike Harkey | | 532 | 591 | -59 |
| 1990-08-22 | @ CIN | 123 | L 1-4 | 59-64 | 4 | 28,707 | Jeff Pico | Jose Rijo | Jose Rijo | Jeff Pico | | 533 | 595 | -62 |
| 1990-08-24 | @ ATL | 124 | L 0-3 | 59-65 | 4 | 20,922 | Greg Maddux | Steve Avery | Steve Avery | Greg Maddux | | 533 | 598 | -65 |
| 1990-08-25 | @ ATL | 125 | W 6-3 | 60-65 | 4 | 29,359 | Mike Bielecki | Tom Glavine | Mike Bielecki | Tom Glavine | Paul Assenmacher | 539 | 601 | -62 |
| 1990-08-26 | @ ATL | 126 | L 3-4 | 60-66 | 4 | 14,178 | Mike Harkey | John Smoltz | John Smoltz | Mitch Williams | | 542 | 605 | -63 |
| 1990-08-28 | @ HOU | 127 | W 5-2 | 61-66 | 4 | 12,150 | Greg Maddux | Bill Gullickson | Greg Maddux | Bill Gullickson | | 547 | 607 | -60 |
| 1990-08-29 | @ HOU | 128 | L 0-1 | 61-67 | 4 | 11,211 | Rick Sutcliffe | Mark Portugal | Mark Portugal | Rick Sutcliffe | Larry Andersen | 547 | 608 | -61 |
| 1990-08-30 | vs CIN | 129 | L 5-6 | 61-68 | 4 | 30,778 | Mike Bielecki | Danny Jackson | Danny Jackson | Mike Bielecki | Randy Myers | 552 | 614 | -62 |
| 1990-08-31 | vs CIN | 130 | W 4-3 | 62-68 | 4 | 31,042 | Mike Harkey | Norm Charlton | Bill Long | Randy Myers | | 556 | 617 | -61 |
| 1990-09-01 | vs CIN | 131 | L 1-8 | 62-69 | 4 | 34,388 | Jose Nunez | Rick Mahler | Rick Mahler | Jose Nunez | | 557 | 625 | -68 |
| 1990-09-02 | vs CIN | 132 | L 2-6 | 62-70 | 4 | 35,043 | Greg Maddux | Jose Rijo | Jose Rijo | Greg Maddux | | 559 | 631 | -72 |
| 1990-09-03 | @ MON | 133 | L 2-3 | 62-71 | 4 | 22,629 | Rick Sutcliffe | Howard Farmer | Steve Frey | Randy Kramer | | 561 | 634 | -73 |
| 1990-09-04 | @ MON | 134 | W 3-1 | 63-71 | 4 | 10,605 | Mike Bielecki | Dennis Martinez | Mike Bielecki | Dennis Martinez | Paul Assenmacher | 564 | 635 | -71 |
| 1990-09-05 | @ PHI | 135 | L 1-4 | 63-72 | 4 | 16,177 | Mike Harkey | Terry Mulholland | Terry Mulholland | Steve Wilson | Roger McDowell | 565 | 639 | -74 |
| 1990-09-06 | @ PHI | 136 | W 5-2 | 64-72 | 4 | 13,849 | Jose Nunez | Jason Grimsley | Jose Nunez | Jason Grimsley | Mitch Williams | 570 | 641 | -71 |
| 1990-09-07 | vs SLN | 137 | L 3-4 | 64-73 | 4 | 23,353 | Greg Maddux | Bob Tewksbury | Bob Tewksbury | Greg Maddux | Lee Smith | 573 | 645 | -72 |
| 1990-09-08 | vs SLN | 138 | W 5-4 | 65-73 | 4 | 32,039 | Rick Sutcliffe | Omar Olivares | Dave Pavlas | Ken Dayley | Paul Assenmacher | 578 | 649 | -71 |
| 1990-09-09 | vs SLN | 139 | L 2-9 | 65-74 | 4 | 27,362 | Mike Bielecki | Bryn Smith | John Tudor | Mike Bielecki | | 580 | 658 | -78 |
| 1990-09-10 | vs MON | 140 | L 4-7 | 65-75 | 4 | 26,774 | Mitch Williams | Chris Nabholz | Chris Nabholz | Bill Long | Tim Burke | 584 | 665 | -81 |
| 1990-09-11 | vs MON | 141 | W 11-6 | 66-75 | 4 | 18,984 | Jose Nunez | Kevin Gross | Dave Pavlas | Kevin Gross | | 595 | 671 | -76 |
| 1990-09-12 | vs PHI | 142 | W 9-3 | 67-75 | 4 | 16,258 | Greg Maddux | Jose De Jesus | Greg Maddux | Jose De Jesus | | 604 | 674 | -70 |
| 1990-09-13 | vs PHI | 143 | W 6-5 | 68-75 | 4 | 15,495 | Rick Sutcliffe | Bruce Ruffin | Paul Assenmacher | Roger McDowell | Les Lancaster | 610 | 679 | -69 |
| 1990-09-14 | @ SLN | 144 | L 2-4 | 68-76 | 4 | 34,473 | Mitch Williams | Bryn Smith | Bryn Smith | Mitch Williams | Mike Perez | 612 | 683 | -71 |
| 1990-09-15 | @ SLN | 145 | W 6-2 | 69-76 | 4 | 42,282 | Randy Kramer | Jose DeLeon | Les Lancaster | Jose DeLeon | | 618 | 685 | -67 |
| 1990-09-16 | @ SLN | 146 | W 8-4 | 70-76 | 4 | 39,402 | Jose Nunez | Ken Hill | Jose Nunez | Ken Hill | Mike Bielecki | 626 | 689 | -63 |
| 1990-09-18 | vs PIT | 147 | W 8-5 | 71-76 | 4 | 23,168 | Greg Maddux | John Smiley | Greg Maddux | John Smiley | | 634 | 694 | -60 |
| 1990-09-19 | vs PIT | 148 | L 7-8 | 71-77 | 4 | 13,058 | Rick Sutcliffe | Doug Drabek | Doug Drabek | Rick Sutcliffe | Bob Patterson | 641 | 702 | -61 |
| 1990-09-20 | vs PIT | 149 | L 2-11 | 71-78 | 4 | 14,926 | Randy Kramer | Bob Walk | Bob Walk | Randy Kramer | Vicente Palacios | 643 | 713 | -70 |
| 1990-09-21 | vs NYN | 150 | W 4-3 | 72-78 | 4 | 19,291 | Steve Wilson | David Cone | Paul Assenmacher | David Cone | | 647 | 716 | -69 |
| 1990-09-22 | vs NYN | 151 | L 5-11 | 72-79 | 4 | 31,066 | Jose Nunez | Ron Darling | Ron Darling | Jose Nunez | | 652 | 727 | -75 |
| 1990-09-23 | vs NYN | 152 | L 3-7 | 72-80 | 4 | 24,385 | Greg Maddux | Dwight Gooden | Dwight Gooden | Greg Maddux | | 655 | 734 | -79 |
| 1990-09-24 | vs NYN | 153 | W 4-3 | 73-80 | 4 | 12,489 | Les Lancaster | Frank Viola | Paul Assenmacher | Frank Viola | | 659 | 737 | -78 |
| 1990-09-25 | @ PIT | 154 | L 3-5 | 73-81 | 4 | 21,644 | Steve Wilson | Doug Drabek | Doug Drabek | Steve Wilson | | 662 | 742 | -80 |
| 1990-09-26 | @ PIT | 155 | L 3-4 | 73-82 | 4 | 26,157 | Kevin Coffman | Zane Smith | Zane Smith | Kevin Coffman | | 665 | 746 | -81 |
| 1990-09-27 | @ PIT | 156 | L 2-3 | 73-83 | 5 | 25,049 | Mike Bielecki | Randy Tomlin | Randy Tomlin | Mike Bielecki | Vicente Palacios | 667 | 749 | -82 |
| 1990-09-28 | @ NYN | 157 | L 1-7 | 73-84 | 5 | 37,586 | Greg Maddux | Dwight Gooden | Dwight Gooden | Greg Maddux | | 668 | 756 | -88 |
| 1990-09-29 | @ NYN | 158 | W 3-2 | 74-84 | 5 | 38,664 | Les Lancaster | Frank Viola | Les Lancaster | Frank Viola | Paul Assenmacher | 671 | 758 | -87 |
| 1990-09-30 | @ NYN | 159 | W 6-5 | 75-84 | 5 | 39,195 | Steve Wilson | Sid Fernandez | Jose Nunez | John Franco | Mitch Williams | 677 | 763 | -86 |
| 1990-10-01 | @ PHI | 160 | L 6-7 | 75-85 | 5 | 9,041 | Kevin Coffman | Jose De Jesus | Jose De Jesus | Kevin Coffman | Roger McDowell | 683 | 770 | -87 |
| 1990-10-02 | @ PHI | 161 | W 3-1 | 76-85 | 5 | 9,940 | Mike Bielecki | Tommy Greene | Mike Bielecki | Tommy Greene | Mitch Williams | 686 | 771 | -85 |
| 1990-10-03 | @ PHI | 162 | W 4-3 | 77-85 | 4 | 11,889 | Greg Maddux | Jason Grimsley | Greg Maddux | Chuck McElroy | Paul Assenmacher | 690 | 774 | -84 |