| 1989-04-04 | @ TEX | 1 | L 0-4 | 0-1 | 6 | 40,375 | Jack Morris | Charlie Hough | Charlie Hough | Jack Morris | | 0 | 4 | -4 |
| 1989-04-06 | @ TEX | 2 | L 4-5 | 0-2 | 7 | 25,735 | Jeff Robinson | Nolan Ryan | Cecilio Guante | Frank Williams | Jeff Russell | 4 | 9 | -5 |
| 1989-04-07 | vs MIL | 3 | W 10-3 | 1-2 | 4 | 51,473 | Doyle Alexander | Bill Wegman | Doyle Alexander | Bill Wegman | Guillermo Hernandez | 14 | 12 | 2 |
| 1989-04-08 | vs MIL | 4 | L 2-5 | 1-3 | 5 | 12,892 | Frank Tanana | Don August | Don August | Frank Tanana | Dan Plesac | 16 | 17 | -1 |
| 1989-04-11 | vs MIN | 5 | L 0-14 | 1-4 | 6 | 9,968 | Jack Morris | Allan Anderson | Allan Anderson | Jack Morris | | 16 | 31 | -15 |
| 1989-04-13 | vs MIN | 6 | W 3-0 | 2-4 | 5 | 9,042 | Jeff Robinson | Shane Rawley | Jeff Robinson | Shane Rawley | | 19 | 31 | -12 |
| 1989-04-14 | vs TEX | 7 | L 2-4 | 2-5 | 7 | 12,384 | Doyle Alexander | Jamie Moyer | Jamie Moyer | Frank Williams | Jeff Russell | 21 | 35 | -14 |
| 1989-04-15 | vs TEX | 8 | L 1-4 | 2-6 | 7 | 17,250 | Frank Tanana | Kevin Brown | Kevin Brown | Frank Tanana | | 22 | 39 | -17 |
| 1989-04-16 | vs TEX | 9 | L 6-9 | 2-7 | 7 | 16,030 | Jack Morris | Charlie Hough | Charlie Hough | Jack Morris | Jeff Russell | 28 | 48 | -20 |
| 1989-04-18 | @ MIN | 10 | L 8-9 | 2-8 | 7 | 20,986 | Jeff Robinson | Shane Rawley | Freddie Toliver | Jeff Robinson | Jeff Reardon | 36 | 57 | -21 |
| 1989-04-19 | @ MIN | 11 | W 3-2 | 3-8 | 7 | 21,840 | Doyle Alexander | Frank Viola | Doyle Alexander | Frank Viola | Guillermo Hernandez | 39 | 59 | -20 |
| 1989-04-20 | @ MIN | 12 | L 2-7 | 3-9 | 7 | 29,878 | Frank Tanana | Roy Smith | German Gonzalez | Frank Tanana | | 41 | 66 | -25 |
| 1989-04-21 | @ MIL | 13 | L 1-2 | 3-10 | 7 | 11,767 | Jack Morris | Chris Bosio | Chris Bosio | Jack Morris | Dan Plesac | 42 | 68 | -26 |
| 1989-04-22 | @ MIL | 14 | W 6-3 | 4-10 | 7 | 22,237 | Charles Hudson | Bill Wegman | Frank Williams | Chuck Crim | | 48 | 71 | -23 |
| 1989-04-23 | @ MIL | 15 | W 11-3 | 5-10 | 7 | 21,854 | Jeff Robinson | Don August | Paul Gibson | Don August | Guillermo Hernandez | 59 | 74 | -15 |
| 1989-04-24 | vs SEA | 16 | W 1-0 | 6-10 | 7 | 13,174 | Doyle Alexander | Mark Langston | Doyle Alexander | Mark Langston | | 60 | 74 | -14 |
| 1989-04-25 | vs SEA | 17 | W 5-2 | 7-10 | 5 | 12,043 | Frank Tanana | Scott Bankhead | Frank Tanana | Scott Bankhead | Guillermo Hernandez | 65 | 76 | -11 |
| 1989-04-26 | @ CAL | 18 | L 0-1 | 7-11 | 5 | 23,334 | Jack Morris | Chuck Finley | Chuck Finley | Jack Morris | Bryan Harvey | 65 | 77 | -12 |
| 1989-04-27 | @ CAL | 19 | L 3-10 | 7-12 | 7 | 25,895 | Charles Hudson | Bert Blyleven | Bert Blyleven | Charles Hudson | | 68 | 87 | -19 |
| 1989-04-28 | @ OAK | 20 | L 1-2 | 7-13 | 7 | 26,594 | Paul Gibson | Mike Moore | Mike Moore | Paul Gibson | Dennis Eckersley | 69 | 89 | -20 |
| 1989-04-29 | @ OAK | 21 | L 2-3 | 7-14 | 7 | 36,313 | Doyle Alexander | Dave Stewart | Dave Stewart | Doyle Alexander | | 71 | 92 | -21 |
| 1989-04-30 | @ OAK | 22 | W 7-2 | 8-14 | 6 | 36,009 | Frank Tanana | Storm Davis | Frank Tanana | Storm Davis | Guillermo Hernandez | 78 | 94 | -16 |
| 1989-05-01 | @ SEA | 23 | L 3-5 | 8-15 | 7 | 14,788 | Jack Morris | Bill Swift | Dennis Powell | Jack Morris | Mike Schooler | 81 | 99 | -18 |
| 1989-05-02 | @ SEA | 24 | L 2-7 | 8-16 | 7 | 10,534 | Charles Hudson | Mike Dunne | Mike Dunne | Charles Hudson | Michael Jackson | 83 | 106 | -23 |
| 1989-05-03 | @ SEA | 25 | L 2-3 | 8-17 | 7 | 9,130 | Doyle Alexander | Erik Hanson | Erik Hanson | Doyle Alexander | Mike Schooler | 85 | 109 | -24 |
| 1989-05-05 | vs OAK | 26 | L 3-5 | 8-18 | 7 | 18,482 | Frank Tanana | Dave Stewart | Dave Stewart | Frank Tanana | Dennis Eckersley | 88 | 114 | -26 |
| 1989-05-06 | vs OAK | 27 | W 6-3 | 9-18 | 6 | 32,404 | Jack Morris | Storm Davis | Jack Morris | Storm Davis | Guillermo Hernandez | 94 | 117 | -23 |
| 1989-05-07 | vs OAK | 28 | L 4-5 | 9-19 | 7 | 20,391 | Jeff Robinson | Bob Welch | Bob Welch | Charles Hudson | Dennis Eckersley | 98 | 122 | -24 |
| 1989-05-08 | vs CAL | 29 | L 2-9 | 9-20 | 7 | 12,759 | Doyle Alexander | Chuck Finley | Chuck Finley | Doyle Alexander | | 100 | 131 | -31 |
| 1989-05-09 | vs CAL | 30 | L 1-5 | 9-21 | 7 | 12,290 | Paul Gibson | Bert Blyleven | Bert Blyleven | Paul Gibson | | 101 | 136 | -35 |
| 1989-05-10 | vs CAL | 31 | W 3-2 | 10-21 | 7 | 13,187 | Frank Tanana | Kirk McCaskill | Guillermo Hernandez | Bryan Harvey | | 104 | 138 | -34 |
| 1989-05-12 | @ CLE | 32 | W 6-3 | 11-21 | 7 | 19,866 | Jack Morris | Buddy Black | Jack Morris | Buddy Black | | 110 | 141 | -31 |
| 1989-05-13 | @ CLE | 33 | L 1-3 | 11-22 | 7 | 16,272 | Doyle Alexander | Greg Swindell | Greg Swindell | Doyle Alexander | | 111 | 144 | -33 |
| 1989-05-14 | @ CLE | 34 | L 3-8 | 11-23 | 7 | 13,906 | Paul Gibson | Tom Candiotti | Tom Candiotti | Paul Gibson | | 114 | 152 | -38 |
| 1989-05-15 | vs CHA | 35 | W 3-2 | 12-23 | 7 | 12,035 | Frank Tanana | Bill Long | Frank Tanana | Bill Long | Guillermo Hernandez | 117 | 154 | -37 |
| 1989-05-16 | vs CHA | 36 | W 9-7 | 13-23 | 7 | 13,861 | Mike Trujillo | Melido Perez | Frank Williams | Melido Perez | | 126 | 161 | -35 |
| 1989-05-17 | vs CHA | 37 | L 7-10 | 13-24 | 7 | 15,975 | Jack Morris | Jerry Reuss | Ken Patterson | Guillermo Hernandez | Shawn Hillegas | 133 | 171 | -38 |
| 1989-05-19 | vs KCA | 38 | W 2-0 | 14-24 | 7 | 18,208 | Doyle Alexander | Bret Saberhagen | Mike Henneman | Bret Saberhagen | | 135 | 171 | -36 |
| 1989-05-20 | vs KCA | 39 | W 2-1 | 15-24 | 7 | 21,287 | Frank Tanana | Floyd Bannister | Mike Henneman | Tom Gordon | | 137 | 172 | -35 |
| 1989-05-21 | vs KCA | 40 | W 4-2 | 16-24 | 7 | 24,853 | Paul Gibson | Mark Gubicza | Paul Gibson | Mark Gubicza | Guillermo Hernandez | 141 | 174 | -33 |
| 1989-05-22 | vs CLE | 41 | L 3-7 | 16-25 | 7 | 13,702 | Jack Morris | Buddy Black | Buddy Black | Jack Morris | Jesse Orosco | 144 | 181 | -37 |
| 1989-05-23 | vs CLE | 42 | W 7-2 | 17-25 | 7 | 13,141 | Mike Trujillo | Greg Swindell | Mike Trujillo | Greg Swindell | | 151 | 183 | -32 |
| 1989-05-24 | vs CLE | 43 | W 2-1 | 18-25 | 5 | 14,352 | Doyle Alexander | Tom Candiotti | Guillermo Hernandez | Scott Bailes | | 153 | 184 | -31 |
| 1989-05-25 | vs CLE | 44 | W 9-5 | 19-25 | 5 | 20,594 | Frank Tanana | John Farrell | Frank Tanana | John Farrell | Guillermo Hernandez | 162 | 189 | -27 |
| 1989-05-26 | @ KCA | 45 | L 3-6 | 19-26 | 5 | 27,728 | Paul Gibson | Floyd Bannister | Jeff Montgomery | Mike Henneman | Steve Farr | 165 | 195 | -30 |
| 1989-05-27 | @ KCA | 46 | L 1-5 | 19-27 | 6 | 32,705 | Randy Nosek | Mark Gubicza | Mark Gubicza | Randy Nosek | | 166 | 200 | -34 |
| 1989-05-28 | @ KCA | 47 | L 5-9 | 19-28 | 7 | 33,610 | Mike Trujillo | Charlie Leibrandt | Tom Gordon | Mike Trujillo | | 171 | 209 | -38 |
| 1989-05-29 | @ CHA | 48 | W 4-2 | 20-28 | 6 | 12,425 | Doyle Alexander | Eric King | Doyle Alexander | Eric King | Guillermo Hernandez | 175 | 211 | -36 |
| 1989-05-30 | @ CHA | 49 | W 10-3 | 21-28 | 5 | 9,227 | Frank Tanana | Jeff Bittiger | Frank Tanana | Jeff Bittiger | Frank Williams | 185 | 214 | -29 |
| 1989-05-31 | @ CHA | 50 | W 4-3 | 22-28 | 5 | 8,549 | Jeff Robinson | Greg Hibbard | Mike Henneman | Bobby Thigpen | Guillermo Hernandez | 189 | 217 | -28 |
| 1989-06-01 | vs BAL | 51 | L 3-8 | 22-29 | 6 | 14,861 | Randy Nosek | Dave J. Schmidt | Dave J. Schmidt | Randy Nosek | Mark Thurmond | 192 | 225 | -33 |
| 1989-06-02 | vs BAL | 52 | L 1-4 | 22-30 | 6 | 19,758 | Mike Trujillo | Bob Milacki | Bob Milacki | Mike Trujillo | Kevin Hickey | 193 | 229 | -36 |
| 1989-06-03 | vs BAL | 53 | L 2-4 | 22-31 | 6 | 19,738 | Doyle Alexander | Brian Holton | Kevin Hickey | Doyle Alexander | Gregg Olson | 195 | 233 | -38 |
| 1989-06-04 | vs BAL | 54 | L 4-7 | 22-32 | 7 | 23,621 | Frank Tanana | Jay Tibbs | Jay Tibbs | Frank Tanana | Mark Williamson | 199 | 240 | -41 |
| 1989-06-05 | vs BOS | 55 | L 2-5 | 22-33 | 7 | 20,722 | David Palmer | Roger Clemens | Roger Clemens | David Palmer | Rob Murphy | 201 | 245 | -44 |
| 1989-06-06 | vs BOS | 56 | W 5-1 | 23-33 | 6 | 16,387 | Mike Schwabe | Joe Price | Mike Schwabe | Joe Price | Guillermo Hernandez | 206 | 246 | -40 |
| 1989-06-07 | vs BOS | 57 | L 1-6 | 23-34 | 7 | 17,741 | Doyle Alexander | John Dopson | John Dopson | Doyle Alexander | | 207 | 252 | -45 |
| 1989-06-09 | @ TOR | 58 | L 0-2 | 23-35 | 7 | 48,219 | Frank Tanana | Dave Stieb | Dave Stieb | Frank Tanana | David Wells | 207 | 254 | -47 |
| 1989-06-10 | @ TOR | 59 | W 11-8 | 24-35 | 7 | 48,430 | Jeff Robinson | Jimmy Key | Frank Williams | Jimmy Key | | 218 | 262 | -44 |
| 1989-06-11 | @ TOR | 60 | L 0-4 | 24-36 | 7 | 48,274 | Mike Schwabe | Mike Flanagan | Mike Flanagan | Mike Schwabe | Duane Ward | 218 | 266 | -48 |
| 1989-06-12 | @ TOR | 61 | L 4-5 | 24-37 | 7 | 48,531 | Doyle Alexander | John Cerutti | Tom Henke | Paul Gibson | | 222 | 271 | -49 |
| 1989-06-13 | @ BOS | 62 | L 7-8 | 24-38 | 7 | 30,969 | David Palmer | John Dopson | Wes Gardner | Frank Williams | Lee Smith | 229 | 279 | -50 |
| 1989-06-14 | @ BOS | 63 | W 7-3 | 25-38 | 7 | 32,656 | Frank Tanana | Mike Boddicker | Frank Tanana | Mike Boddicker | | 236 | 282 | -46 |
| 1989-06-16 | vs CAL | 64 | L 4-9 | 25-39 | 7 | 26,140 | Mike Schwabe | Bert Blyleven | Bert Blyleven | Mike Schwabe | Bryan Harvey | 240 | 291 | -51 |
| 1989-06-17 | vs CAL | 65 | L 3-6 | 25-40 | 7 | 39,961 | Doyle Alexander | Jim Abbott | Jim Abbott | Doyle Alexander | Bob McClure | 243 | 297 | -54 |
| 1989-06-18 | vs CAL | 66 | L 1-3 | 25-41 | 7 | 25,928 | David Palmer | Mike Witt | Mike Witt | David Palmer | Bryan Harvey | 244 | 300 | -56 |
| 1989-06-19 | @ OAK | 67 | W 6-4 | 26-41 | 7 | 38,607 | Frank Tanana | Dave Stewart | Frank Tanana | Dave Stewart | Mike Henneman | 250 | 304 | -54 |
| 1989-06-20 | @ OAK | 68 | L 4-6 | 26-42 | 7 | 30,184 | Charles Hudson | Storm Davis | Gene Nelson | Brad Havens | Todd Burns | 254 | 310 | -56 |
| 1989-06-21 | @ OAK | 69 | L 3-6 | 26-43 | 7 | 28,654 | Mike Schwabe | Mike Moore | Mike Moore | Mike Schwabe | Rick Honeycutt | 257 | 316 | -59 |
| 1989-06-23 | @ SEA | 70 | W 5-4 | 27-43 | 7 | 14,007 | Doyle Alexander | Gene Harris | Mike Henneman | Mike Schooler | | 262 | 320 | -58 |
| 1989-06-24 | @ SEA | 71 | L 1-3 | 27-44 | 7 | 15,824 | Frank Tanana | Scott Bankhead | Scott Bankhead | Frank Tanana | Mike Schooler | 263 | 323 | -60 |
| 1989-06-25 | @ SEA | 72 | L 3-5 | 27-45 | 7 | 19,950 | David Palmer | Bill Swift | Bill Swift | David Palmer | Michael Jackson | 266 | 328 | -62 |
| 1989-06-27 | vs NYA | 73 | W 6-5 | 28-45 | 7 | 22,077 | Paul Gibson | Jimmy Jones | Brad Havens | Lee Guetterman | | 272 | 333 | -61 |
| 1989-06-28 | vs NYA | 74 | W 6-5 | 29-45 | 7 | 22,256 | Doyle Alexander | Dave Eiland | Mike Henneman | Dave Righetti | | 278 | 338 | -60 |
| 1989-06-29 | vs NYA | 75 | L 6-7 | 29-46 | 7 | 22,455 | Frank Tanana | Dave LaPoint | Eric Plunk | Ed Nunez | Dave Righetti | 284 | 345 | -61 |
| 1989-06-30 | @ BAL | 76 | W 16-5 | 30-46 | 7 | 40,594 | David Palmer | Bob Milacki | Mike Schwabe | Bob Milacki | | 300 | 350 | -50 |
| 1989-07-01 | @ BAL | 77 | L 1-8 | 30-47 | 7 | 39,943 | Charles Hudson | Jeff Ballard | Jeff Ballard | Charles Hudson | | 301 | 358 | -57 |
| 1989-07-02 | @ BAL | 78 | W 7-3 | 31-47 | 7 | 39,609 | Paul Gibson | Jay Tibbs | Ed Nunez | Mark Thurmond | Mike Henneman | 308 | 361 | -53 |
| 1989-07-03 | @ BAL | 79 | L 4-11 | 31-48 | 7 | 35,656 | Doyle Alexander | Brian Holton | Mike Smith | Doyle Alexander | | 312 | 372 | -60 |
| 1989-07-04 | @ NYA | 80 | L 0-1 | 31-49 | 7 | 32,198 | Frank Tanana | Don Schulze | Don Schulze | Frank Tanana | Lee Guetterman | 312 | 373 | -61 |
| 1989-07-05 | @ NYA | 81 | L 0-9 | 31-50 | 7 | 20,206 | Brad Havens | Andy Hawkins | Andy Hawkins | Brad Havens | | 312 | 382 | -70 |
| 1989-07-06 | @ NYA | 82 | L 5-6 | 31-51 | 7 | 23,357 | Charles Hudson | Clay Parker | Eric Plunk | Mike Henneman | | 317 | 388 | -71 |
| 1989-07-07 | vs TOR | 83 | L 4-6 | 31-52 | 7 | 25,213 | Paul Gibson | Mike Flanagan | Steve Cummings | Guillermo Hernandez | Tom Henke | 321 | 394 | -73 |
| 1989-07-08 | vs TOR | 84 | L 3-8 | 31-53 | 7 | 31,342 | Doyle Alexander | John Cerutti | John Cerutti | Doyle Alexander | Duane Ward | 324 | 402 | -78 |
| 1989-07-09 | vs TOR | 85 | L 0-2 | 31-54 | 7 | 32,428 | Frank Tanana | Dave Stieb | Dave Stieb | Frank Tanana | Tom Henke | 324 | 404 | -80 |
| 1989-07-13 | vs SEA | 86 | L 4-5 | 31-55 | 7 | 14,879 | Paul Gibson | Randy Johnson | Bill Swift | Mike Schwabe | | 328 | 409 | -81 |
| 1989-07-14 | vs SEA | 87 | L 0-13 | 31-56 | 7 | 18,059 | Doyle Alexander | Brian Holman | Brian Holman | Doyle Alexander | | 328 | 422 | -94 |
| 1989-07-15 | vs SEA | 88 | L 3-9 | 31-57 | 7 | 22,894 | Kevin Ritz | Scott Bankhead | Scott Bankhead | Kevin Ritz | | 331 | 431 | -100 |
| 1989-07-16 | vs SEA | 89 | W 8-5 | 32-57 | 7 | 21,768 | Charles Hudson | Gene Harris | Charles Hudson | Gene Harris | Ed Nunez | 339 | 436 | -97 |
| 1989-07-17 | vs OAK | 90 | W 2-1 | 33-57 | 7 | 21,844 | Paul Gibson | Curt Young | Mike Henneman | Gene Nelson | | 341 | 437 | -96 |
| 1989-07-18 | vs OAK | 91 | L 2-7 | 33-58 | 7 | 21,792 | Dave Beard | Storm Davis | Storm Davis | Dave Beard | | 343 | 444 | -101 |
| 1989-07-20 | @ CAL | 92 | L 3-4 | 33-59 | 7 | 26,854 | Doyle Alexander | Chuck Finley | Chuck Finley | Mike Henneman | | 346 | 448 | -102 |
| 1989-07-21 | @ CAL | 93 | L 7-8 | 33-60 | 7 | 34,924 | Frank Tanana | Mike Witt | Bryan Harvey | Dave Beard | | 353 | 456 | -103 |
| 1989-07-22 | @ CAL | 94 | L 4-5 | 33-61 | 7 | 48,766 | Paul Gibson | Jim Abbott | Dan Petry | Charles Hudson | | 357 | 461 | -104 |
| 1989-07-23 | @ CAL | 95 | L 4-5 | 33-62 | 7 | 29,444 | Kevin Ritz | Bert Blyleven | Bob McClure | Mike Henneman | | 361 | 466 | -105 |
| 1989-07-24 | @ MIL | 96 | L 0-10 | 33-63 | 7 | 17,981 | Jack Morris | Chris Bosio | Chris Bosio | Jack Morris | | 361 | 476 | -115 |
| 1989-07-25 | @ MIL | 97 | W 7-2 | 34-63 | 7 | 16,737 | Doyle Alexander | Don August | Doyle Alexander | Don August | | 368 | 478 | -110 |
| 1989-07-26 | @ MIL | 98 | L 2-3 | 34-64 | 7 | 23,957 | Frank Tanana | Teddy Higuera | Teddy Higuera | Ed Nunez | Dan Plesac | 370 | 481 | -111 |
| 1989-07-27 | @ MIL | 99 | L 1-11 | 34-65 | 7 | 30,451 | Paul Gibson | Jaime Navarro | Jaime Navarro | Paul Gibson | | 371 | 492 | -121 |
| 1989-07-28 | vs MIN | 100 | W 6-4 | 35-66 | 7 | 0 | Kevin Ritz | Frank Viola | Kevin Ritz | Frank Viola | Mike Henneman | 377 | 496 | -119 |
| 1989-07-28 | vs MIN | 101 | L 3-7 | 35-66 | 7 | 24,322 | Jeff Robinson | Mike Dyer | Mike Dyer | Jeff Robinson | | 380 | 503 | -123 |
| 1989-07-29 | vs MIN | 102 | W 3-2 | 36-66 | 7 | 32,864 | Jack Morris | Mark Guthrie | Mike Henneman | Gary Wayne | | 383 | 505 | -122 |
| 1989-07-30 | vs MIN | 103 | L 3-14 | 36-67 | 7 | 23,775 | Doyle Alexander | Allan Anderson | Allan Anderson | Doyle Alexander | | 386 | 519 | -133 |
| 1989-08-01 | vs TEX | 104 | L 3-4 | 36-68 | 7 | 15,305 | Frank Tanana | Kevin Brown | Kevin Brown | Paul Gibson | Jeff Russell | 389 | 523 | -134 |
| 1989-08-02 | vs TEX | 105 | W 6-4 | 37-68 | 7 | 14,884 | Kevin Ritz | Mike Jeffcoat | Kevin Ritz | Mike Jeffcoat | | 395 | 527 | -132 |
| 1989-08-03 | vs TEX | 106 | W 9-6 | 38-68 | 7 | 16,039 | Jeff Robinson | Bobby Witt | Mike Henneman | Cecilio Guante | | 404 | 533 | -129 |
| 1989-08-04 | @ CHA | 107 | L 4-5 | 38-69 | 7 | 16,918 | Jack Morris | Steve Rosenberg | Ken Patterson | Paul Gibson | | 408 | 538 | -130 |
| 1989-08-05 | @ CHA | 108 | L 6-7 | 38-70 | 7 | 19,266 | Doyle Alexander | Eric King | Eric King | Doyle Alexander | Bobby Thigpen | 414 | 545 | -131 |
| 1989-08-06 | @ CHA | 109 | W 4-3 | 39-70 | 7 | 14,418 | Frank Tanana | Greg Hibbard | Frank Tanana | Greg Hibbard | | 418 | 548 | -130 |
| 1989-08-07 | vs MIL | 110 | W 5-3 | 40-71 | 7 | 0 | Kevin Ritz | Chris Bosio | Kevin Ritz | Tony Fossas | Mike Henneman | 423 | 551 | -128 |
| 1989-08-07 | vs MIL | 111 | L 2-5 | 40-71 | 7 | 18,577 | Paul Gibson | Tom Filer | Tom Filer | Paul Gibson | Dan Plesac | 425 | 556 | -131 |
| 1989-08-08 | vs MIL | 112 | W 6-3 | 41-71 | 7 | 16,503 | Jeff Robinson | Don August | Jeff Robinson | Don August | Guillermo Hernandez | 431 | 559 | -128 |
| 1989-08-09 | vs MIL | 113 | L 1-6 | 41-72 | 7 | 24,348 | Jack Morris | Jerry Reuss | Chuck Crim | Jack Morris | Dan Plesac | 432 | 565 | -133 |
| 1989-08-10 | @ TEX | 114 | L 1-4 | 41-73 | 7 | 35,266 | Doyle Alexander | Nolan Ryan | Nolan Ryan | Doyle Alexander | Jeff Russell | 433 | 569 | -136 |
| 1989-08-11 | @ TEX | 115 | L 3-7 | 41-74 | 7 | 26,400 | Frank Tanana | Kevin Brown | Kevin Brown | Frank Tanana | | 436 | 576 | -140 |
| 1989-08-12 | @ TEX | 116 | W 6-5 | 42-74 | 7 | 38,421 | Kevin Ritz | Mike Jeffcoat | Paul Gibson | Kenny Rogers | Guillermo Hernandez | 442 | 581 | -139 |
| 1989-08-13 | @ TEX | 117 | W 4-2 | 43-74 | 7 | 21,056 | Jeff Robinson | Bobby Witt | Mike Henneman | Kenny Rogers | Guillermo Hernandez | 446 | 583 | -137 |
| 1989-08-14 | vs BAL | 118 | L 1-4 | 43-75 | 7 | 17,447 | Jack Morris | Brian Holton | Dave J. Schmidt | Jack Morris | Gregg Olson | 447 | 587 | -140 |
| 1989-08-15 | vs BAL | 119 | L 0-2 | 43-76 | 7 | 16,203 | Doyle Alexander | Bob Milacki | Bob Milacki | Doyle Alexander | | 447 | 589 | -142 |
| 1989-08-16 | vs BAL | 120 | W 4-0 | 44-76 | 7 | 17,092 | Frank Tanana | Pete Harnisch | Frank Tanana | Pete Harnisch | | 451 | 589 | -138 |
| 1989-08-17 | vs NYA | 121 | L 1-2 | 44-77 | 7 | 23,863 | Brian Dubois | Greg Cadaret | Greg Cadaret | Brian Dubois | Dave Righetti | 452 | 591 | -139 |
| 1989-08-18 | vs NYA | 122 | W 7-3 | 45-77 | 7 | 30,432 | Jeff Robinson | Chuck Cary | Jeff Robinson | Chuck Cary | | 459 | 594 | -135 |
| 1989-08-19 | vs NYA | 123 | W 5-4 | 46-77 | 7 | 30,454 | Jack Morris | Andy Hawkins | Jack Morris | Dave Righetti | | 464 | 598 | -134 |
| 1989-08-20 | vs NYA | 124 | W 7-6 | 47-77 | 7 | 33,499 | Steve Searcy | Clay Parker | Ed Nunez | Eric Plunk | Mike Henneman | 471 | 604 | -133 |
| 1989-08-21 | vs OAK | 125 | L 1-6 | 47-78 | 7 | 6,197 | Frank Tanana | Curt Young | Curt Young | Frank Tanana | | 472 | 610 | -138 |
| 1989-08-22 | @ TOR | 126 | L 2-3 | 47-79 | 7 | 49,072 | Brian Dubois | Todd Stottlemyre | Mauro Gozzo | Ed Nunez | | 474 | 613 | -139 |
| 1989-08-23 | @ TOR | 127 | L 4-11 | 47-80 | 7 | 49,233 | Jeff Robinson | John Cerutti | Frank Wills | Jeff Robinson | | 478 | 624 | -146 |
| 1989-08-24 | @ TOR | 128 | L 3-11 | 47-81 | 7 | 49,201 | Jack Morris | Mike Flanagan | Mike Flanagan | Jack Morris | | 481 | 635 | -154 |
| 1989-08-25 | @ BOS | 129 | L 2-4 | 47-83 | 7 | 0 | Doyle Alexander | Mike Smithson | Mike Smithson | Doyle Alexander | Rob Murphy | 483 | 639 | -156 |
| 1989-08-25 | @ BOS | 130 | L 3-11 | 47-83 | 7 | 35,158 | Kevin Ritz | Eric Hetzel | Dennis Lamp | Kevin Ritz | | 486 | 650 | -164 |
| 1989-08-26 | @ BOS | 131 | L 2-5 | 47-84 | 7 | 34,643 | Frank Tanana | Roger Clemens | Roger Clemens | Frank Tanana | Lee Smith | 488 | 655 | -167 |
| 1989-08-27 | @ BOS | 132 | L 1-7 | 47-85 | 7 | 34,252 | Brian Dubois | Wes Gardner | Joe Price | Brian Dubois | | 489 | 662 | -173 |
| 1989-08-28 | @ BOS | 133 | L 3-6 | 47-86 | 7 | 33,307 | Jeff Robinson | Mike Boddicker | Mike Boddicker | Jeff Robinson | Lee Smith | 492 | 668 | -176 |
| 1989-08-29 | @ KCA | 134 | L 8-12 | 47-87 | 7 | 21,130 | Jack Morris | Luis Aquino | Steve Crawford | Steve Searcy | | 500 | 680 | -180 |
| 1989-08-30 | @ KCA | 135 | L 1-6 | 47-88 | 7 | 20,176 | Doyle Alexander | Mark Gubicza | Mark Gubicza | Doyle Alexander | | 501 | 686 | -185 |
| 1989-08-31 | @ KCA | 136 | L 0-3 | 47-89 | 7 | 30,004 | Kevin Ritz | Bret Saberhagen | Bret Saberhagen | Kevin Ritz | Jeff Montgomery | 501 | 689 | -188 |
| 1989-09-01 | vs CLE | 137 | W 2-1 | 48-89 | 7 | 14,576 | Frank Tanana | Buddy Black | Paul Gibson | Doug Jones | | 503 | 690 | -187 |
| 1989-09-02 | vs CLE | 138 | W 10-4 | 49-89 | 7 | 17,207 | Jeff Robinson | Steve Davis | Jeff Robinson | Steve Davis | | 513 | 694 | -181 |
| 1989-09-03 | vs CLE | 139 | W 12-3 | 50-89 | 7 | 18,130 | Jack Morris | Tom Candiotti | Jack Morris | Tom Candiotti | | 525 | 697 | -172 |
| 1989-09-04 | vs KCA | 140 | W 5-1 | 51-89 | 7 | 17,412 | Doyle Alexander | Bret Saberhagen | Doyle Alexander | Bret Saberhagen | Mike Henneman | 530 | 698 | -168 |
| 1989-09-05 | vs KCA | 141 | W 10-2 | 52-89 | 7 | 12,742 | Kevin Ritz | Tom Gordon | Kevin Ritz | Tom Gordon | | 540 | 700 | -160 |
| 1989-09-06 | vs KCA | 142 | W 11-5 | 53-89 | 7 | 12,903 | Frank Tanana | Charlie Leibrandt | Ed Nunez | Charlie Leibrandt | Brian Dubois | 551 | 705 | -154 |
| 1989-09-08 | vs CHA | 143 | W 7-5 | 54-89 | 7 | 14,586 | Jack Morris | Greg Hibbard | Jack Morris | Greg Hibbard | Mike Henneman | 558 | 710 | -152 |
| 1989-09-09 | vs CHA | 144 | L 3-13 | 54-90 | 7 | 18,791 | Jeff Robinson | Melido Perez | Melido Perez | Jeff Robinson | | 561 | 723 | -162 |
| 1989-09-10 | vs CHA | 145 | W 6-5 | 55-90 | 7 | 15,597 | Doyle Alexander | Richard Dotson | Mike Henneman | Bobby Thigpen | | 567 | 728 | -161 |
| 1989-09-12 | @ CLE | 146 | L 0-1 | 55-91 | 7 | 5,523 | Frank Tanana | Buddy Black | Buddy Black | Frank Tanana | | 567 | 729 | -162 |
| 1989-09-13 | @ CLE | 147 | W 3-1 | 56-91 | 7 | 5,068 | Jack Morris | Tom Candiotti | Jack Morris | Tom Candiotti | | 570 | 730 | -160 |
| 1989-09-14 | @ CLE | 148 | L 0-4 | 56-92 | 7 | 7,300 | Kevin Ritz | Rod Nichols | Rod Nichols | Kevin Ritz | Jesse Orosco | 570 | 734 | -164 |
| 1989-09-15 | @ MIN | 149 | L 4-8 | 56-93 | 7 | 22,156 | Brian Dubois | Rick Aguilera | Rick Aguilera | Brian Dubois | Tim Drummond | 574 | 742 | -168 |
| 1989-09-16 | @ MIN | 150 | L 7-8 | 56-94 | 7 | 31,727 | Doyle Alexander | Allan Anderson | Allan Anderson | Doyle Alexander | Gary Wayne | 581 | 750 | -169 |
| 1989-09-17 | @ MIN | 151 | W 9-2 | 57-94 | 7 | 24,489 | Steve Searcy | Mike Dyer | Steve Searcy | Mike Dyer | | 590 | 752 | -162 |
| 1989-09-19 | @ BAL | 152 | L 2-6 | 57-95 | 7 | 22,378 | Jack Morris | Bob Milacki | Bob Milacki | Jack Morris | Mark Williamson | 592 | 758 | -166 |
| 1989-09-20 | @ BAL | 153 | L 2-9 | 57-96 | 7 | 30,644 | Frank Tanana | Jeff Ballard | Jeff Ballard | Frank Tanana | | 594 | 767 | -173 |
| 1989-09-22 | vs BOS | 154 | L 7-9 | 57-97 | 7 | 16,341 | Doyle Alexander | John Dopson | Rob Murphy | Ed Nunez | Lee Smith | 601 | 776 | -175 |
| 1989-09-23 | vs BOS | 155 | L 1-6 | 57-98 | 7 | 22,783 | Kevin Ritz | Mike Boddicker | Mike Boddicker | Kevin Ritz | Rob Murphy | 602 | 782 | -180 |
| 1989-09-24 | vs BOS | 156 | L 2-4 | 57-99 | 7 | 16,601 | Jack Morris | Oil Can Boyd | Oil Can Boyd | Jack Morris | Lee Smith | 604 | 786 | -182 |
| 1989-09-25 | vs TOR | 157 | L 0-2 | 57-100 | 7 | 15,990 | Brian Dubois | Jimmy Key | Jimmy Key | Brian Dubois | Tom Henke | 604 | 788 | -184 |
| 1989-09-26 | vs TOR | 158 | W 4-3 | 58-100 | 7 | 16,185 | Frank Tanana | Mike Flanagan | Mike Henneman | Duane Ward | | 608 | 791 | -183 |
| 1989-09-27 | vs TOR | 159 | L 1-8 | 58-101 | 7 | 18,331 | Doyle Alexander | Dave Stieb | Dave Stieb | Doyle Alexander | Tom Henke | 609 | 799 | -190 |
| 1989-09-29 | @ NYA | 160 | L 1-5 | 58-102 | 7 | 21,448 | Jack Morris | Eric Plunk | Eric Plunk | Jack Morris | | 610 | 804 | -194 |
| 1989-09-30 | @ NYA | 161 | L 2-9 | 58-103 | 7 | 20,313 | Kevin Ritz | Andy Hawkins | Andy Hawkins | Kevin Ritz | Lee Guetterman | 612 | 813 | -201 |
| 1989-10-01 | @ NYA | 162 | W 5-3 | 59-103 | 7 | 30,079 | Frank Tanana | Kevin Mmahat | Frank Tanana | Kevin Mmahat | Mike Henneman | 617 | 816 | -199 |