| 1986-04-08 | vs CAL | 1 | W 8-4 | 1-0 | 2 | 42,121 | Mike Moore | Mike Witt | Pete Ladd | Ken Forsch | | 8 | 4 | 4 |
| 1986-04-09 | vs CAL | 2 | L 5-9 | 1-1 | 3 | 12,199 | Mark Langston | John Candelaria | Jim Slaton | Mark Langston | | 13 | 13 | 0 |
| 1986-04-10 | vs CAL | 3 | W 5-2 | 2-1 | 2 | 10,780 | Matt Young | Don Sutton | Matt Young | Don Sutton | | 18 | 15 | 3 |
| 1986-04-11 | @ MIN | 4 | L 1-5 | 2-2 | 2 | 42,871 | Milt Wilcox | Bert Blyleven | Bert Blyleven | Milt Wilcox | Ron Davis | 19 | 20 | -1 |
| 1986-04-12 | @ MIN | 5 | W 10-4 | 3-2 | 2 | 14,708 | Mike Morgan | Frank Viola | Mike Morgan | Frank Viola | | 29 | 24 | 5 |
| 1986-04-13 | @ MIN | 6 | W 4-2 | 4-2 | 1 | 11,222 | Mike Moore | Mike Smithson | Mike Moore | Mike Smithson | | 33 | 26 | 7 |
| 1986-04-14 | @ CAL | 7 | L 6-7 | 4-3 | 2 | 37,489 | Mark Langston | Jim Slaton | Donnie Moore | Pete Ladd | | 39 | 33 | 6 |
| 1986-04-15 | @ CAL | 8 | W 9-4 | 5-3 | 1 | 24,422 | Matt Young | Don Sutton | Matt Young | Don Sutton | Mike Morgan | 48 | 37 | 11 |
| 1986-04-16 | @ CAL | 9 | L 0-4 | 5-4 | 3 | 22,510 | Milt Wilcox | Ron Romanick | Ron Romanick | Milt Wilcox | | 48 | 41 | 7 |
| 1986-04-18 | vs OAK | 10 | L 1-4 | 5-5 | 5 | 16,740 | Mike Moore | Chris Codiroli | Chris Codiroli | Mike Moore | Jay Howell | 49 | 45 | 4 |
| 1986-04-19 | vs OAK | 11 | L 2-7 | 5-6 | 5 | 31,584 | Mark Langston | Jose Rijo | Jose Rijo | Mark Langston | | 51 | 52 | -1 |
| 1986-04-20 | vs OAK | 12 | L 3-9 | 5-7 | 5 | 12,027 | Matt Young | Moose Haas | Moose Haas | Matt Young | | 54 | 61 | -7 |
| 1986-04-21 | vs MIN | 13 | L 2-5 | 5-8 | 6 | 13,106 | Milt Wilcox | Frank Viola | Frank Viola | Milt Wilcox | | 56 | 66 | -10 |
| 1986-04-22 | vs MIN | 14 | L 1-7 | 5-9 | 6 | 7,044 | Mike Morgan | Mike Smithson | Mike Smithson | Mike Morgan | | 57 | 73 | -16 |
| 1986-04-23 | vs MIN | 15 | W 4-3 | 6-9 | 6 | 7,547 | Mike Moore | John Butcher | Karl Best | Mark Portugal | | 61 | 76 | -15 |
| 1986-04-24 | @ OAK | 16 | W 3-1 | 7-9 | 6 | 12,289 | Mark Langston | Jose Rijo | Mark Langston | Jose Rijo | Karl Best | 64 | 77 | -13 |
| 1986-04-25 | @ OAK | 17 | L 2-11 | 7-10 | 6 | 10,303 | Matt Young | Moose Haas | Moose Haas | Matt Young | | 66 | 88 | -22 |
| 1986-04-26 | @ OAK | 18 | L 3-5 | 7-11 | 6 | 20,109 | Milt Wilcox | Joaquin Andujar | Joaquin Andujar | Milt Wilcox | | 69 | 93 | -24 |
| 1986-04-27 | @ OAK | 19 | L 0-1 | 7-12 | 6 | 16,228 | Mike Morgan | Rick Langford | Rick Langford | Mike Morgan | Jay Howell | 69 | 94 | -25 |
| 1986-04-29 | @ BOS | 20 | L 1-3 | 7-13 | 6 | 13,414 | Mike Moore | Roger Clemens | Roger Clemens | Mike Moore | | 70 | 97 | -27 |
| 1986-04-30 | @ BOS | 21 | L 4-9 | 7-14 | 7 | 13,161 | Mark Langston | Bruce Hurst | Sammy Stewart | Ed Nunez | Bob Stanley | 74 | 106 | -32 |
| 1986-05-01 | @ BOS | 22 | L 2-12 | 7-15 | 7 | 13,109 | Bill Swift | Oil Can Boyd | Oil Can Boyd | Bill Swift | | 76 | 118 | -42 |
| 1986-05-02 | @ TOR | 23 | W 3-2 | 8-15 | 7 | 18,134 | Milt Wilcox | Jim Clancy | Pete Ladd | Mark Eichhorn | | 79 | 120 | -41 |
| 1986-05-03 | @ TOR | 24 | W 4-2 | 9-15 | 6 | 27,115 | Mike Morgan | Jim Acker | Mike Morgan | Jim Acker | Pete Ladd | 83 | 122 | -39 |
| 1986-05-04 | @ TOR | 25 | L 2-3 | 9-16 | 6 | 22,154 | Mike Moore | Dave Stieb | Tom Henke | Mike Moore | | 85 | 125 | -40 |
| 1986-05-05 | @ MIL | 26 | L 1-3 | 9-17 | 6 | 6,846 | Mark Langston | Tim Leary | Tim Leary | Mark Langston | Dan Plesac | 86 | 128 | -42 |
| 1986-05-06 | @ MIL | 27 | L 0-10 | 9-18 | 6 | 8,947 | Bill Swift | Juan Nieves | Juan Nieves | Bill Swift | | 86 | 138 | -52 |
| 1986-05-07 | vs BOS | 28 | L 5-11 | 9-19 | 6 | 8,523 | Milt Wilcox | Al Nipper | Al Nipper | Milt Wilcox | | 91 | 149 | -58 |
| 1986-05-08 | vs BOS | 29 | L 2-4 | 9-20 | 6 | 8,319 | Mike Morgan | Mike Brown | Mike Brown | Mike Morgan | Bob Stanley | 93 | 153 | -60 |
| 1986-05-09 | vs TOR | 30 | W 13-3 | 10-20 | 6 | 12,026 | Mike Moore | Dave Stieb | Mike Moore | Dave Stieb | | 106 | 156 | -50 |
| 1986-05-10 | vs TOR | 31 | W 8-7 | 11-20 | 6 | 20,155 | Mark Langston | Doyle Alexander | Pete Ladd | Tom Henke | | 114 | 163 | -49 |
| 1986-05-11 | vs TOR | 32 | L 3-4 | 11-21 | 7 | 10,172 | Bill Swift | Jimmy Key | Jimmy Key | Bill Swift | Mark Eichhorn | 117 | 167 | -50 |
| 1986-05-12 | vs MIL | 33 | W 6-0 | 12-21 | 6 | 13,129 | Milt Wilcox | Teddy Higuera | Matt Young | Teddy Higuera | | 123 | 167 | -44 |
| 1986-05-13 | vs MIL | 34 | W 8-5 | 13-21 | 6 | 8,421 | Mike Morgan | Tim Leary | Mike Morgan | Tim Leary | Pete Ladd | 131 | 172 | -41 |
| 1986-05-14 | vs MIL | 35 | L 6-9 | 13-22 | 6 | 9,714 | Mike Moore | Juan Nieves | Dan Plesac | Mike Moore | | 137 | 181 | -44 |
| 1986-05-16 | @ NYA | 36 | W 7-3 | 14-22 | 6 | 18,321 | Mark Langston | Joe Niekro | Mark Langston | Joe Niekro | Pete Ladd | 144 | 184 | -40 |
| 1986-05-17 | @ NYA | 37 | L 6-11 | 14-23 | 6 | 18,324 | Matt Young | Bob Tewksbury | Bob Tewksbury | Matt Young | | 150 | 195 | -45 |
| 1986-05-18 | @ NYA | 38 | L 3-11 | 14-24 | 7 | 40,182 | Mike Morgan | Dennis Rasmussen | Dennis Rasmussen | Mike Morgan | | 153 | 206 | -53 |
| 1986-05-20 | @ DET | 39 | L 0-12 | 14-25 | 7 | 12,660 | Mike Moore | Walt Terrell | Walt Terrell | Mike Moore | | 153 | 218 | -65 |
| 1986-05-21 | @ DET | 40 | L 4-6 | 14-26 | 7 | 13,117 | Mark Langston | Frank Tanana | Eric King | Mark Langston | | 157 | 224 | -67 |
| 1986-05-22 | @ DET | 41 | W 5-3 | 15-26 | 6 | 18,953 | Milt Wilcox | Dan Petry | Matt Young | Dan Petry | Pete Ladd | 162 | 227 | -65 |
| 1986-05-23 | vs BAL | 42 | L 5-7 | 15-27 | 7 | 12,266 | Mike Morgan | Ken Dixon | Ken Dixon | Mike Morgan | Don Aase | 167 | 234 | -67 |
| 1986-05-24 | vs BAL | 43 | L 4-5 | 15-28 | 7 | 16,230 | Bill Swift | Mike Flanagan | Nate Snell | Mark Huismann | | 171 | 239 | -68 |
| 1986-05-25 | vs BAL | 44 | L 3-6 | 15-29 | 7 | 11,614 | Mike Moore | Mike Boddicker | Mike Boddicker | Mike Moore | | 174 | 245 | -71 |
| 1986-05-26 | vs BAL | 45 | W 7-6 | 16-29 | 7 | 14,344 | Mark Langston | Storm Davis | Mark Langston | Storm Davis | Matt Young | 181 | 251 | -70 |
| 1986-05-28 | vs NYA | 46 | L 5-6 | 16-30 | 7 | 12,890 | Mike Morgan | Bob Tewksbury | Ed Whitson | Mike Morgan | Dave Righetti | 186 | 257 | -71 |
| 1986-05-29 | vs NYA | 47 | L 0-2 | 16-31 | 7 | 13,889 | Milt Wilcox | Dennis Rasmussen | Dennis Rasmussen | Milt Wilcox | Dave Righetti | 186 | 259 | -73 |
| 1986-05-30 | vs DET | 48 | W 8-7 | 17-31 | 7 | 17,471 | Mike Moore | Jack Morris | Mark Huismann | Chuck Cary | | 194 | 266 | -72 |
| 1986-05-31 | vs DET | 49 | W 7-4 | 18-31 | 7 | 27,841 | Mark Langston | Walt Terrell | Mark Langston | Walt Terrell | Matt Young | 201 | 270 | -69 |
| 1986-06-01 | vs DET | 50 | W 9-1 | 19-31 | 7 | 8,691 | Bill Swift | Frank Tanana | Bill Swift | Frank Tanana | Mark Huismann | 210 | 271 | -61 |
| 1986-06-03 | @ BAL | 51 | L 2-4 | 19-32 | 7 | 14,446 | Milt Wilcox | Mike Boddicker | Mike Boddicker | Milt Wilcox | Don Aase | 212 | 275 | -63 |
| 1986-06-04 | @ BAL | 52 | W 5-1 | 20-32 | 6 | 18,047 | Mike Moore | Ken Dixon | Mike Moore | Ken Dixon | | 217 | 276 | -59 |
| 1986-06-05 | @ BAL | 53 | L 1-7 | 20-33 | 7 | 20,130 | Mark Langston | Storm Davis | Storm Davis | Mark Langston | | 218 | 283 | -65 |
| 1986-06-06 | @ TEX | 54 | L 5-6 | 20-34 | 7 | 24,814 | Bill Swift | Mike Mason | Mitch Williams | Pete Ladd | | 223 | 289 | -66 |
| 1986-06-07 | @ TEX | 55 | L 5-7 | 20-36 | 7 | 0 | Mike Morgan | Jose Guzman | Jose Guzman | Matt Young | Greg Harris | 228 | 296 | -68 |
| 1986-06-07 | @ TEX | 56 | L 2-3 | 20-36 | 7 | 34,735 | Lee Guetterman | Charlie Hough | Charlie Hough | Lee Guetterman | Greg Harris | 230 | 299 | -69 |
| 1986-06-08 | @ TEX | 57 | L 4-5 | 20-37 | 7 | 28,328 | Mike Moore | Ed Correa | Mitch Williams | Karl Best | | 234 | 304 | -70 |
| 1986-06-09 | @ KCA | 58 | W 5-3 | 21-37 | 7 | 28,242 | Mark Langston | Dennis Leonard | Mark Langston | Dennis Leonard | Mark Huismann | 239 | 307 | -68 |
| 1986-06-10 | @ KCA | 59 | L 5-9 | 21-38 | 7 | 23,319 | Bill Swift | Scott Bankhead | Steve Farr | Milt Wilcox | | 244 | 316 | -72 |
| 1986-06-11 | @ KCA | 60 | W 12-2 | 22-38 | 7 | 26,230 | Mike Morgan | Charlie Leibrandt | Mike Morgan | Charlie Leibrandt | | 256 | 318 | -62 |
| 1986-06-12 | vs CHA | 61 | L 4-8 | 22-39 | 7 | 8,439 | Jim Beattie | Joe Cowley | Joe Cowley | Lee Guetterman | | 260 | 326 | -66 |
| 1986-06-13 | vs CHA | 62 | W 11-10 | 23-39 | 7 | 10,242 | Mike Moore | Joel Davis | Matt Young | Bill Dawley | | 271 | 336 | -65 |
| 1986-06-14 | vs CHA | 63 | W 7-3 | 24-39 | 7 | 21,304 | Mark Langston | Tom Seaver | Mark Langston | Tom Seaver | Matt Young | 278 | 339 | -61 |
| 1986-06-15 | vs CHA | 64 | W 10-5 | 25-39 | 7 | 18,190 | Bill Swift | Neil Allen | Steve Fireovid | Joel McKeon | | 288 | 344 | -56 |
| 1986-06-17 | @ CLE | 65 | W 5-2 | 26-39 | 7 | 7,053 | Mike Morgan | Phil Niekro | Mike Morgan | Phil Niekro | | 293 | 346 | -53 |
| 1986-06-18 | @ CLE | 66 | L 1-5 | 26-40 | 7 | 8,545 | Jim Beattie | Ken Schrom | Ken Schrom | Jim Beattie | Scott Bailes | 294 | 351 | -57 |
| 1986-06-19 | @ CLE | 67 | L 1-8 | 26-41 | 7 | 8,791 | Mike Moore | Tom Candiotti | Tom Candiotti | Mike Moore | | 295 | 359 | -64 |
| 1986-06-20 | @ CHA | 68 | W 5-3 | 27-41 | 7 | 26,391 | Mark Langston | Tom Seaver | Mark Langston | Tom Seaver | Matt Young | 300 | 362 | -62 |
| 1986-06-21 | @ CHA | 69 | L 6-7 | 27-42 | 7 | 21,934 | Bill Swift | Neil Allen | Neil Allen | Bill Swift | Bill Dawley | 306 | 369 | -63 |
| 1986-06-22 | @ CHA | 70 | L 4-10 | 27-43 | 7 | 25,522 | Mike Morgan | Richard Dotson | Richard Dotson | Mike Morgan | | 310 | 379 | -69 |
| 1986-06-23 | vs CLE | 71 | L 6-8 | 27-44 | 7 | 12,259 | Jim Beattie | Ken Schrom | Ken Schrom | Jim Beattie | Ernie Camacho | 316 | 387 | -71 |
| 1986-06-24 | vs CLE | 72 | W 8-7 | 28-44 | 7 | 6,968 | Mike Moore | Tom Candiotti | Matt Young | Ernie Camacho | | 324 | 394 | -70 |
| 1986-06-25 | vs CLE | 73 | W 6-1 | 29-44 | 7 | 8,372 | Mark Langston | John Butcher | Mark Langston | John Butcher | | 330 | 395 | -65 |
| 1986-06-26 | vs TEX | 74 | L 3-10 | 29-45 | 7 | 8,127 | Lee Guetterman | Charlie Hough | Charlie Hough | Lee Guetterman | | 333 | 405 | -72 |
| 1986-06-27 | vs TEX | 75 | W 6-5 | 30-45 | 7 | 8,324 | Mike Morgan | Mike Mason | Matt Young | Jeff Russell | | 339 | 410 | -71 |
| 1986-06-28 | vs TEX | 76 | L 2-5 | 30-46 | 7 | 10,606 | Jim Beattie | Jose Guzman | Jose Guzman | Jim Beattie | | 341 | 415 | -74 |
| 1986-06-29 | vs TEX | 77 | W 9-3 | 31-46 | 6 | 12,799 | Mike Moore | Ed Correa | Mike Moore | Ed Correa | | 350 | 418 | -68 |
| 1986-06-30 | vs KCA | 78 | W 3-2 | 32-46 | 6 | 20,611 | Mark Langston | Dennis Leonard | Mark Langston | Dennis Leonard | Matt Young | 353 | 420 | -67 |
| 1986-07-01 | vs KCA | 79 | W 8-5 | 33-46 | 6 | 9,966 | Lee Guetterman | Charlie Leibrandt | Pete Ladd | Dan Quisenberry | | 361 | 425 | -64 |
| 1986-07-02 | vs KCA | 80 | W 5-3 | 34-46 | 6 | 13,976 | Mike Morgan | Scott Bankhead | Mike Morgan | Scott Bankhead | Matt Young | 366 | 428 | -62 |
| 1986-07-04 | @ BOS | 81 | L 5-6 | 34-47 | 6 | 19,237 | Jim Beattie | Jeff Sellers | Jeff Sellers | Jim Beattie | Joe Sambito | 371 | 434 | -63 |
| 1986-07-05 | @ BOS | 82 | W 9-5 | 35-47 | 6 | 26,224 | Mike Moore | Al Nipper | Mike Moore | Al Nipper | Matt Young | 380 | 439 | -59 |
| 1986-07-06 | @ BOS | 83 | L 3-7 | 35-48 | 6 | 27,625 | Mark Langston | Tom Seaver | Tom Seaver | Mark Langston | Bob Stanley | 383 | 446 | -63 |
| 1986-07-07 | @ TOR | 84 | L 5-7 | 35-49 | 6 | 26,208 | Mike Morgan | Jimmy Key | Jimmy Key | Mike Morgan | Bill Caudill | 388 | 453 | -65 |
| 1986-07-08 | @ TOR | 85 | W 8-5 | 36-49 | 6 | 28,241 | Lee Guetterman | John Cerutti | Mark Huismann | John Cerutti | Matt Young | 396 | 458 | -62 |
| 1986-07-09 | @ TOR | 86 | L 5-6 | 36-50 | 6 | 30,044 | Mike Moore | Dave Stieb | Bill Caudill | Mike Moore | Tom Henke | 401 | 464 | -63 |
| 1986-07-10 | @ MIL | 87 | W 4-1 | 37-50 | 5 | 8,963 | Mark Langston | Danny Darwin | Steve Fireovid | Danny Darwin | Pete Ladd | 405 | 465 | -60 |
| 1986-07-11 | @ MIL | 88 | W 9-3 | 38-50 | 5 | 18,290 | Mike Morgan | Tim Leary | Mike Morgan | Tim Leary | | 414 | 468 | -54 |
| 1986-07-12 | @ MIL | 89 | W 15-9 | 39-50 | 5 | 25,946 | Jerry Reed | Bill Wegman | Jerry Reed | Bill Wegman | Mark Huismann | 429 | 477 | -48 |
| 1986-07-13 | @ MIL | 90 | L 0-5 | 39-51 | 5 | 10,532 | Mike Moore | Juan Nieves | Juan Nieves | Mike Moore | | 429 | 482 | -53 |
| 1986-07-17 | vs BOS | 91 | W 5-1 | 40-51 | 5 | 14,688 | Mark Langston | Tom Seaver | Pete Ladd | Bob Stanley | | 434 | 483 | -49 |
| 1986-07-18 | vs BOS | 92 | W 10-4 | 41-51 | 5 | 20,830 | Mike Moore | Al Nipper | Mike Moore | Al Nipper | | 444 | 487 | -43 |
| 1986-07-19 | vs BOS | 93 | L 4-9 | 41-52 | 5 | 31,703 | Mike Morgan | Roger Clemens | Roger Clemens | Mike Morgan | | 448 | 496 | -48 |
| 1986-07-20 | vs BOS | 94 | W 9-5 | 42-52 | 5 | 12,873 | Jerry Reed | Jeff Sellers | Jerry Reed | Jeff Sellers | | 457 | 501 | -44 |
| 1986-07-21 | vs TOR | 95 | L 3-8 | 42-53 | 5 | 17,823 | Mark Huismann | John Cerutti | John Cerutti | Mark Huismann | | 460 | 509 | -49 |
| 1986-07-22 | vs TOR | 96 | W 8-7 | 43-53 | 5 | 10,152 | Mark Langston | Jimmy Key | Jerry Reed | Bill Caudill | | 468 | 516 | -48 |
| 1986-07-23 | vs TOR | 97 | L 2-6 | 43-54 | 5 | 11,485 | Mike Moore | Jim Clancy | Jim Clancy | Mike Moore | Dave Stieb | 470 | 522 | -52 |
| 1986-07-25 | vs MIL | 98 | L 2-4 | 43-55 | 5 | 17,001 | Mike Morgan | Teddy Higuera | Teddy Higuera | Mike Morgan | Mark Clear | 472 | 526 | -54 |
| 1986-07-26 | vs MIL | 99 | W 5-2 | 44-55 | 4 | 14,570 | Jerry Reed | Bill Wegman | Jerry Reed | Bill Wegman | Matt Young | 477 | 528 | -51 |
| 1986-07-27 | vs MIL | 100 | L 1-8 | 44-56 | 4 | 12,918 | Mark Langston | Tim Leary | Tim Leary | Mark Langston | | 478 | 536 | -58 |
| 1986-07-28 | @ MIN | 101 | L 5-6 | 44-57 | 4 | 14,879 | Mike Moore | Mike Smithson | Keith Atherton | Karl Best | | 483 | 542 | -59 |
| 1986-07-29 | @ MIN | 102 | L 2-4 | 44-58 | 6 | 10,991 | Jim Beattie | Frank Viola | Frank Viola | Jim Beattie | Roy Lee Jackson | 485 | 546 | -61 |
| 1986-07-30 | @ MIN | 103 | W 4-2 | 45-58 | 5 | 10,396 | Mike Morgan | Neal Heaton | Mike Morgan | Neal Heaton | Matt Young | 489 | 548 | -59 |
| 1986-08-01 | vs CAL | 104 | L 2-3 | 45-59 | 5 | 11,588 | Mark Langston | Don Sutton | Don Sutton | Mark Langston | Donnie Moore | 491 | 551 | -60 |
| 1986-08-02 | vs CAL | 105 | W 7-3 | 46-59 | 5 | 16,447 | Mike Moore | Kirk McCaskill | Mark Huismann | Kirk McCaskill | | 498 | 554 | -56 |
| 1986-08-03 | vs CAL | 106 | W 6-3 | 47-59 | 5 | 8,906 | Jerry Reed | Ray Chadwick | Pete Ladd | Ray Chadwick | | 504 | 557 | -53 |
| 1986-08-04 | vs OAK | 107 | W 9-8 | 48-59 | 4 | 17,229 | Mike Morgan | Jose Rijo | Karl Best | Bill Mooneyham | Mike Moore | 513 | 565 | -52 |
| 1986-08-05 | vs OAK | 108 | L 4-10 | 48-60 | 5 | 8,902 | Jim Beattie | Curt Young | Curt Young | Jim Beattie | | 517 | 575 | -58 |
| 1986-08-06 | vs OAK | 109 | L 5-7 | 48-61 | 5 | 9,863 | Mark Langston | Eric Plunk | Jay Howell | Matt Young | | 522 | 582 | -60 |
| 1986-08-07 | @ CAL | 110 | L 3-4 | 48-62 | 6 | 27,970 | Mike Moore | Kirk McCaskill | Donnie Moore | Pete Ladd | | 525 | 586 | -61 |
| 1986-08-08 | @ CAL | 111 | L 4-6 | 48-63 | 7 | 29,950 | Bill Swift | Vern Ruhle | Vern Ruhle | Bill Swift | Doug Corbett | 529 | 592 | -63 |
| 1986-08-09 | @ CAL | 112 | L 0-5 | 48-64 | 7 | 37,373 | Mike Morgan | John Candelaria | John Candelaria | Mike Morgan | | 529 | 597 | -68 |
| 1986-08-10 | @ CAL | 113 | L 0-4 | 48-65 | 7 | 28,939 | Mark Langston | Mike Witt | Mike Witt | Mark Langston | | 529 | 601 | -72 |
| 1986-08-11 | @ OAK | 114 | W 6-4 | 49-65 | 7 | 13,547 | Mike Moore | Eric Plunk | Pete Ladd | Doug Bair | | 535 | 605 | -70 |
| 1986-08-12 | @ OAK | 115 | L 2-3 | 49-66 | 7 | 8,582 | Steve Fireovid | Joaquin Andujar | Jay Howell | Pete Ladd | | 537 | 608 | -71 |
| 1986-08-13 | @ OAK | 116 | L 1-4 | 49-67 | 7 | 11,170 | Mike Morgan | Dave Stewart | Dave Stewart | Mike Morgan | Jay Howell | 538 | 612 | -74 |
| 1986-08-14 | vs MIN | 117 | L 1-14 | 49-68 | 7 | 8,743 | Mark Langston | Mark Portugal | Mark Portugal | Mark Langston | | 539 | 626 | -87 |
| 1986-08-15 | vs MIN | 118 | W 1-0 | 50-68 | 7 | 7,726 | Mike Moore | Neal Heaton | Mike Moore | Keith Atherton | | 540 | 626 | -86 |
| 1986-08-16 | vs MIN | 119 | W 7-6 | 51-68 | 7 | 15,535 | Bill Swift | Bert Blyleven | Pete Ladd | Keith Atherton | | 547 | 632 | -85 |
| 1986-08-17 | vs MIN | 120 | W 11-1 | 52-68 | 6 | 8,253 | Mike Morgan | Mike Smithson | Mike Morgan | Mike Smithson | | 558 | 633 | -75 |
| 1986-08-19 | @ NYA | 121 | W 7-3 | 53-68 | 6 | 23,169 | Mark Langston | Tommy John | Mark Langston | Tommy John | | 565 | 636 | -71 |
| 1986-08-20 | @ NYA | 122 | L 2-5 | 53-69 | 6 | 26,205 | Mike Moore | Doug Drabek | Tim Stoddard | Mike Moore | Dave Righetti | 567 | 641 | -74 |
| 1986-08-22 | @ DET | 123 | L 1-4 | 53-70 | 7 | 22,013 | Mike Morgan | Eric King | Eric King | Mike Morgan | | 568 | 645 | -77 |
| 1986-08-23 | @ DET | 124 | L 0-14 | 53-71 | 7 | 25,712 | Mike Brown | Frank Tanana | Frank Tanana | Mike Brown | | 568 | 659 | -91 |
| 1986-08-24 | @ DET | 125 | W 3-1 | 54-71 | 6 | 33,777 | Mark Langston | Dan Petry | Mark Langston | Dan Petry | Matt Young | 571 | 660 | -89 |
| 1986-08-26 | vs BAL | 126 | W 5-2 | 55-71 | 5 | 8,111 | Mike Moore | Ken Dixon | Mike Moore | Ken Dixon | Matt Young | 576 | 662 | -86 |
| 1986-08-27 | vs BAL | 127 | W 4-1 | 56-71 | 5 | 7,628 | Mike Trujillo | Mike Boddicker | Mike Trujillo | Mike Boddicker | Mark Huismann | 580 | 663 | -83 |
| 1986-08-28 | vs NYA | 128 | L 2-4 | 56-72 | 5 | 13,343 | Mike Morgan | Dennis Rasmussen | Dennis Rasmussen | Mike Morgan | Dave Righetti | 582 | 667 | -85 |
| 1986-08-29 | vs NYA | 129 | L 12-13 | 56-73 | 5 | 14,211 | Mark Langston | Ron Guidry | Tim Stoddard | Karl Best | Dave Righetti | 594 | 680 | -86 |
| 1986-08-30 | vs NYA | 130 | W 1-0 | 57-74 | 5 | 0 | Bill Swift | Tommy John | Bill Swift | Tommy John | Matt Young | 595 | 680 | -85 |
| 1986-08-30 | vs NYA | 131 | L 0-3 | 57-74 | 5 | 26,065 | Mike Brown | Joe Niekro | Joe Niekro | Mike Brown | Dave Righetti | 595 | 683 | -88 |
| 1986-08-31 | vs NYA | 132 | W 6-2 | 58-74 | 5 | 11,944 | Mike Moore | Doug Drabek | Mike Moore | Doug Drabek | | 601 | 685 | -84 |
| 1986-09-01 | vs DET | 133 | L 5-6 | 58-75 | 6 | 13,410 | Mike Morgan | Jack Morris | Jack Morris | Mike Morgan | | 606 | 691 | -85 |
| 1986-09-02 | vs DET | 134 | L 5-7 | 58-76 | 6 | 6,108 | Mark Langston | Eric King | Bill Campbell | Lee Guetterman | Jim Slaton | 611 | 698 | -87 |
| 1986-09-03 | vs DET | 135 | W 3-2 | 59-76 | 6 | 6,743 | Bill Swift | Frank Tanana | Mike Trujillo | Bryan Kelly | | 614 | 700 | -86 |
| 1986-09-05 | @ BAL | 136 | W 8-2 | 60-76 | 5 | 31,203 | Mike Moore | Ken Dixon | Mike Moore | Ken Dixon | | 622 | 702 | -80 |
| 1986-09-06 | @ BAL | 137 | W 6-2 | 61-76 | 5 | 25,586 | Mike Morgan | Mike Boddicker | Mike Morgan | Mike Boddicker | | 628 | 704 | -76 |
| 1986-09-07 | @ BAL | 138 | L 0-8 | 61-77 | 5 | 19,892 | Mark Langston | Scott McGregor | Scott McGregor | Mark Langston | | 628 | 712 | -84 |
| 1986-09-09 | @ TEX | 139 | W 3-1 | 62-77 | 5 | 8,222 | Ed Nunez | Jose Guzman | Ed Nunez | Jose Guzman | Mike Trujillo | 631 | 713 | -82 |
| 1986-09-10 | @ TEX | 140 | L 2-3 | 62-78 | 5 | 9,246 | Mike Moore | Bobby Witt | Greg Harris | Matt Young | | 633 | 716 | -83 |
| 1986-09-11 | @ KCA | 141 | L 6-7 | 62-79 | 5 | 20,419 | Mike Morgan | Charlie Leibrandt | Dan Quisenberry | Mark Huismann | | 639 | 723 | -84 |
| 1986-09-12 | @ KCA | 142 | W 4-2 | 63-79 | 5 | 22,169 | Mark Langston | Danny Jackson | Mark Langston | Dan Quisenberry | | 643 | 725 | -82 |
| 1986-09-13 | @ KCA | 143 | L 4-5 | 63-80 | 5 | 31,138 | Bill Swift | Dennis Leonard | Dennis Leonard | Bill Swift | Buddy Black | 647 | 730 | -83 |
| 1986-09-14 | @ KCA | 144 | L 3-10 | 63-81 | 6 | 22,063 | Mike Moore | Mark Gubicza | Mark Gubicza | Mike Moore | | 650 | 740 | -90 |
| 1986-09-16 | vs CHA | 145 | W 7-0 | 64-81 | 5 | 5,818 | Mike Morgan | Richard Dotson | Mike Morgan | Richard Dotson | | 657 | 740 | -83 |
| 1986-09-17 | vs CHA | 146 | L 0-3 | 64-82 | 6 | 6,033 | Mark Langston | Floyd Bannister | Floyd Bannister | Mark Langston | Bobby Thigpen | 657 | 743 | -86 |
| 1986-09-18 | vs CHA | 147 | L 4-6 | 64-83 | 6 | 5,903 | Bill Swift | Steve Carlton | Steve Carlton | Bill Swift | Gene Nelson | 661 | 749 | -88 |
| 1986-09-19 | vs KCA | 148 | W 6-5 | 65-83 | 6 | 10,828 | Mike Moore | Mark Gubicza | Matt Young | Buddy Black | | 667 | 754 | -87 |
| 1986-09-20 | vs KCA | 149 | W 3-0 | 66-83 | 6 | 10,899 | Mike Trujillo | Bret Saberhagen | Mike Trujillo | Bret Saberhagen | | 670 | 754 | -84 |
| 1986-09-21 | vs KCA | 150 | L 1-8 | 66-84 | 6 | 9,554 | Mike Morgan | Charlie Leibrandt | Charlie Leibrandt | Mike Morgan | | 671 | 762 | -91 |
| 1986-09-22 | vs TEX | 151 | L 0-2 | 66-85 | 6 | 7,495 | Mark Langston | Ed Correa | Ed Correa | Mark Langston | | 671 | 764 | -93 |
| 1986-09-23 | vs TEX | 152 | L 6-12 | 66-86 | 6 | 5,311 | Bill Swift | Charlie Hough | Charlie Hough | Bill Swift | | 677 | 776 | -99 |
| 1986-09-24 | vs TEX | 153 | W 5-4 | 67-86 | 5 | 5,413 | Mike Moore | Jose Guzman | Mike Moore | Jose Guzman | Pete Ladd | 682 | 780 | -98 |
| 1986-09-26 | vs CLE | 154 | L 7-9 | 67-87 | 5 | 6,061 | Mike Trujillo | Tom Candiotti | Doug Jones | Pete Ladd | | 689 | 789 | -100 |
| 1986-09-27 | vs CLE | 155 | L 4-12 | 67-88 | 6 | 14,430 | Mike Morgan | Ken Schrom | Ken Schrom | Mike Morgan | | 693 | 801 | -108 |
| 1986-09-28 | vs CLE | 156 | L 4-5 | 67-89 | 6 | 6,654 | Mark Langston | Scott Bailes | Frank Wills | Ed Nunez | Ernie Camacho | 697 | 806 | -109 |
| 1986-09-30 | @ CHA | 157 | L 4-5 | 67-91 | 7 | 0 | Mike Moore | Steve Carlton | Dave J. Schmidt | Pete Ladd | | 701 | 811 | -110 |
| 1986-09-30 | @ CHA | 158 | L 4-5 | 67-91 | 7 | 8,528 | Bill Swift | Joe Cowley | Ray Searage | Bill Swift | Dave J. Schmidt | 705 | 816 | -111 |
| 1986-10-01 | @ CHA | 159 | L 1-3 | 67-92 | 7 | 8,951 | Mike Trujillo | Neil Allen | Bob James | Mike Trujillo | Bill Dawley | 706 | 819 | -113 |
| 1986-10-03 | @ CLE | 160 | L 5-6 | 67-93 | 7 | 7,963 | Mike Morgan | Ken Schrom | Frank Wills | Mike Trujillo | | 711 | 825 | -114 |
| 1986-10-04 | @ CLE | 161 | L 5-6 | 67-94 | 7 | 11,991 | Mark Langston | Greg Swindell | Greg Swindell | Mark Langston | Ernie Camacho | 716 | 831 | -115 |
| 1986-10-05 | @ CLE | 162 | L 2-4 | 67-95 | 7 | 12,175 | Mike Moore | Tom Candiotti | Tom Candiotti | Mike Moore | | 718 | 835 | -117 |