| 1985-04-08 | @ DET | 1 | L 4-5 | 0-1 | 4 | 51,180 | Bert Blyleven | Jack Morris | Jack Morris | Ernie Camacho | Guillermo Hernandez | 4 | 5 | -1 |
| 1985-04-10 | @ DET | 2 | L 1-8 | 0-2 | 5 | 14,659 | Vern Ruhle | Dan Petry | Dan Petry | Vern Ruhle | Aurelio Lopez | 5 | 13 | -8 |
| 1985-04-11 | @ DET | 3 | L 10-11 | 0-3 | 6 | 19,090 | Don Schulze | Walt Terrell | Guillermo Hernandez | Dave Von Ohlen | | 15 | 24 | -9 |
| 1985-04-13 | vs NYA | 4 | L 3-6 | 0-4 | 7 | 61,978 | Bert Blyleven | Ron Guidry | Ron Guidry | Bert Blyleven | Dave Righetti | 18 | 30 | -12 |
| 1985-04-14 | vs NYA | 5 | L 1-2 | 0-5 | 7 | 12,085 | Neal Heaton | Phil Niekro | Phil Niekro | Tom Waddell | Dave Righetti | 19 | 32 | -13 |
| 1985-04-16 | vs BAL | 6 | W 6-3 | 1-5 | 7 | 4,220 | Vern Ruhle | Dennis Martinez | Vern Ruhle | Dennis Martinez | Tom Waddell | 25 | 35 | -10 |
| 1985-04-17 | vs BAL | 7 | L 3-6 | 1-6 | 7 | 4,315 | Don Schulze | Scott McGregor | Sammy Stewart | Jose Roman | | 28 | 41 | -13 |
| 1985-04-18 | vs BAL | 8 | W 11-5 | 2-6 | 7 | 5,013 | Bert Blyleven | Storm Davis | Dave Von Ohlen | Nate Snell | | 39 | 46 | -7 |
| 1985-04-19 | @ NYA | 9 | W 2-1 | 3-6 | 7 | 21,229 | Neal Heaton | Ron Guidry | Neal Heaton | Ron Guidry | Tom Waddell | 41 | 47 | -6 |
| 1985-04-20 | @ NYA | 10 | L 2-5 | 3-7 | 7 | 20,188 | Jose Roman | Phil Niekro | Phil Niekro | Jose Roman | Dave Righetti | 43 | 52 | -9 |
| 1985-04-21 | @ NYA | 11 | W 3-0 | 4-7 | 7 | 34,443 | Vern Ruhle | Ed Whitson | Dave Von Ohlen | Ed Whitson | Tom Waddell | 46 | 52 | -6 |
| 1985-04-22 | vs DET | 12 | W 6-4 | 5-7 | 7 | 5,667 | Don Schulze | Jack Morris | Don Schulze | Jack Morris | Tom Waddell | 52 | 56 | -4 |
| 1985-04-23 | vs DET | 13 | L 3-4 | 5-8 | 7 | 7,654 | Bert Blyleven | Dan Petry | Dan Petry | Bert Blyleven | Guillermo Hernandez | 55 | 60 | -5 |
| 1985-04-24 | vs DET | 14 | W 7-6 | 6-8 | 6 | 7,224 | Neal Heaton | Walt Terrell | Jamie Easterly | Aurelio Lopez | | 62 | 66 | -4 |
| 1985-04-25 | @ BAL | 15 | L 1-7 | 6-9 | 7 | 19,494 | Jose Roman | Ken Dixon | Ken Dixon | Jose Roman | | 63 | 73 | -10 |
| 1985-04-26 | @ BAL | 16 | L 3-6 | 6-10 | 7 | 36,104 | Vern Ruhle | Dennis Martinez | Dennis Martinez | Vern Ruhle | Sammy Stewart | 66 | 79 | -13 |
| 1985-04-27 | @ BAL | 17 | W 10-4 | 7-10 | 6 | 31,288 | Don Schulze | Scott McGregor | Don Schulze | Scott McGregor | | 76 | 83 | -7 |
| 1985-04-28 | @ BAL | 18 | L 7-8 | 7-11 | 6 | 33,293 | Bert Blyleven | Storm Davis | Don Aase | Tom Waddell | | 83 | 91 | -8 |
| 1985-04-29 | @ KCA | 19 | L 2-3 | 7-12 | 6 | 19,295 | Neal Heaton | Buddy Black | Buddy Black | Neal Heaton | Dan Quisenberry | 85 | 94 | -9 |
| 1985-04-30 | @ KCA | 20 | L 1-5 | 7-13 | 6 | 16,282 | Jose Roman | Bret Saberhagen | Bret Saberhagen | Jose Roman | | 86 | 99 | -13 |
| 1985-05-01 | @ KCA | 21 | W 6-5 | 8-13 | 6 | 16,699 | Don Schulze | Mark Gubicza | Don Schulze | Mark Gubicza | Tom Waddell | 92 | 104 | -12 |
| 1985-05-03 | vs TEX | 22 | W 4-0 | 9-13 | 6 | 7,919 | Bert Blyleven | Mike Mason | Bert Blyleven | Mike Mason | | 96 | 104 | -8 |
| 1985-05-04 | vs TEX | 23 | W 3-1 | 10-13 | 5 | 6,685 | Neal Heaton | Frank Tanana | Neal Heaton | Frank Tanana | Tom Waddell | 99 | 105 | -6 |
| 1985-05-05 | vs TEX | 24 | L 2-7 | 10-14 | 6 | 10,231 | Don Schulze | Charlie Hough | Charlie Hough | Don Schulze | Greg Harris | 101 | 112 | -11 |
| 1985-05-07 | vs CHA | 25 | L 4-7 | 10-15 | 7 | 5,076 | Bert Blyleven | Floyd Bannister | Floyd Bannister | Bert Blyleven | Bob James | 105 | 119 | -14 |
| 1985-05-08 | vs CHA | 26 | L 0-4 | 10-16 | 7 | 4,808 | Neal Heaton | Britt Burns | Britt Burns | Neal Heaton | | 105 | 123 | -18 |
| 1985-05-10 | @ TEX | 27 | L 2-5 | 10-17 | 7 | 10,461 | Don Schulze | Charlie Hough | Charlie Hough | Don Schulze | Dave Rozema | 107 | 128 | -21 |
| 1985-05-11 | @ TEX | 28 | W 4-1 | 11-17 | 6 | 13,257 | Keith Creel | Frank Tanana | Tom Waddell | Greg Harris | | 111 | 129 | -18 |
| 1985-05-12 | @ TEX | 29 | W 6-0 | 12-17 | 6 | 10,626 | Bert Blyleven | Dickie Noles | Bert Blyleven | Dickie Noles | | 117 | 129 | -12 |
| 1985-05-13 | @ CHA | 30 | L 0-8 | 12-18 | 7 | 14,389 | Neal Heaton | Britt Burns | Britt Burns | Neal Heaton | | 117 | 137 | -20 |
| 1985-05-14 | @ CHA | 31 | L 1-2 | 12-19 | 7 | 13,007 | Vern Ruhle | Tim Lollar | Gene Nelson | Rich Thompson | Bob James | 118 | 139 | -21 |
| 1985-05-15 | vs KCA | 32 | L 1-5 | 12-20 | 7 | 4,169 | Don Schulze | Charlie Leibrandt | Charlie Leibrandt | Don Schulze | | 119 | 144 | -25 |
| 1985-05-16 | vs KCA | 33 | L 1-7 | 12-21 | 7 | 3,051 | Keith Creel | Buddy Black | Buddy Black | Keith Creel | | 120 | 151 | -31 |
| 1985-05-17 | vs BOS | 34 | L 0-5 | 12-22 | 7 | 5,502 | Bert Blyleven | Roger Clemens | Roger Clemens | Bert Blyleven | | 120 | 156 | -36 |
| 1985-05-18 | vs BOS | 35 | W 4-1 | 13-22 | 7 | 5,843 | Neal Heaton | Bruce Hurst | Neal Heaton | Bruce Hurst | Tom Waddell | 124 | 157 | -33 |
| 1985-05-19 | vs BOS | 36 | W 2-1 | 14-22 | 7 | 13,544 | Vern Ruhle | Oil Can Boyd | Rich Thompson | Oil Can Boyd | | 126 | 158 | -32 |
| 1985-05-21 | vs MIL | 37 | W 6-4 | 15-22 | 6 | 4,004 | Keith Creel | Teddy Higuera | Bryan Clark | Teddy Higuera | Rich Thompson | 132 | 162 | -30 |
| 1985-05-22 | vs MIL | 38 | L 5-6 | 15-23 | 7 | 4,084 | Bert Blyleven | Danny Darwin | Bob Gibson | Bert Blyleven | Rollie Fingers | 137 | 168 | -31 |
| 1985-05-23 | vs TOR | 39 | L 5-6 | 15-24 | 7 | 4,333 | Neal Heaton | Jim Clancy | Dennis Lamp | Tom Waddell | Bill Caudill | 142 | 174 | -32 |
| 1985-05-24 | vs TOR | 40 | L 6-7 | 15-25 | 7 | 8,502 | Keith Creel | Doyle Alexander | Dennis Lamp | Keith Creel | Gary Lavelle | 148 | 181 | -33 |
| 1985-05-25 | vs TOR | 41 | L 7-10 | 15-26 | 7 | 7,345 | Don Schulze | Jimmy Key | Ron Musselman | Rich Thompson | Jim Acker | 155 | 191 | -36 |
| 1985-05-26 | vs TOR | 42 | L 5-6 | 15-27 | 7 | 13,255 | Bryan Clark | Luis Leal | Gary Lavelle | Keith Creel | Bill Caudill | 160 | 197 | -37 |
| 1985-05-27 | @ MIL | 43 | W 8-0 | 16-27 | 7 | 11,612 | Bert Blyleven | Danny Darwin | Bert Blyleven | Danny Darwin | | 168 | 197 | -29 |
| 1985-05-28 | @ MIL | 44 | L 2-3 | 16-28 | 7 | 7,179 | Neal Heaton | Moose Haas | Moose Haas | Neal Heaton | Rollie Fingers | 170 | 200 | -30 |
| 1985-05-29 | @ MIL | 45 | L 2-7 | 16-29 | 7 | 7,779 | Don Schulze | Ray Burris | Ray Burris | Don Schulze | Bob Gibson | 172 | 207 | -35 |
| 1985-05-31 | @ TOR | 46 | L 2-7 | 16-30 | 7 | 24,166 | Bryan Clark | Doyle Alexander | Doyle Alexander | Bryan Clark | Jim Acker | 174 | 214 | -40 |
| 1985-06-01 | @ TOR | 47 | L 3-8 | 16-31 | 7 | 33,296 | Bert Blyleven | Jimmy Key | Jimmy Key | Bert Blyleven | | 177 | 222 | -45 |
| 1985-06-02 | @ TOR | 48 | W 5-4 | 17-32 | 7 | 0 | Neal Heaton | Dave Stieb | Neal Heaton | Dave Stieb | Tom Waddell | 182 | 226 | -44 |
| 1985-06-02 | @ TOR | 49 | L 2-5 | 17-32 | 7 | 35,315 | Rick Behenna | Luis Leal | Luis Leal | Rick Behenna | Jim Acker | 184 | 231 | -47 |
| 1985-06-03 | @ BOS | 50 | L 5-6 | 17-33 | 7 | 15,180 | Don Schulze | Oil Can Boyd | Oil Can Boyd | Don Schulze | | 189 | 237 | -48 |
| 1985-06-04 | @ BOS | 51 | L 0-5 | 17-34 | 7 | 16,336 | Keith Creel | Bob Ojeda | Bob Ojeda | Keith Creel | | 189 | 242 | -53 |
| 1985-06-06 | vs SEA | 52 | W 9-1 | 18-34 | 7 | 3,730 | Bert Blyleven | Matt Young | Bert Blyleven | Matt Young | | 198 | 243 | -45 |
| 1985-06-07 | vs SEA | 53 | L 4-6 | 18-35 | 7 | 16,023 | Neal Heaton | Brian Snyder | Bill Swift | Neal Heaton | Ed Vande Berg | 202 | 249 | -47 |
| 1985-06-08 | vs SEA | 54 | W 12-8 | 19-35 | 7 | 6,261 | Rick Behenna | Jim Beattie | Tom Waddell | Mike Stanton | | 214 | 257 | -43 |
| 1985-06-09 | vs SEA | 55 | L 6-10 | 19-36 | 7 | 9,841 | Don Schulze | Frank Wills | Frank Wills | Don Schulze | Ed Nunez | 220 | 267 | -47 |
| 1985-06-10 | vs MIN | 56 | L 4-6 | 19-37 | 7 | 4,056 | Keith Creel | Frank Viola | Frank Viola | Keith Creel | Ron Davis | 224 | 273 | -49 |
| 1985-06-14 | vs OAK | 57 | W 6-1 | 20-37 | 7 | 6,380 | Bert Blyleven | Bill Krueger | Bert Blyleven | Bill Krueger | | 230 | 274 | -44 |
| 1985-06-15 | vs OAK | 58 | L 6-8 | 20-38 | 7 | 7,182 | Neal Heaton | Tim Birtsas | Tim Birtsas | Neal Heaton | Jay Howell | 236 | 282 | -46 |
| 1985-06-16 | vs OAK | 59 | L 2-3 | 20-40 | 7 | 0 | Rick Behenna | Don Sutton | Don Sutton | Tom Waddell | Jay Howell | 238 | 285 | -47 |
| 1985-06-16 | vs OAK | 60 | L 6-11 | 20-40 | 7 | 11,732 | Vern Ruhle | Steve McCatty | Steve McCatty | Vern Ruhle | | 244 | 296 | -52 |
| 1985-06-18 | vs CAL | 61 | L 3-7 | 20-41 | 7 | 5,891 | Neal Heaton | Mike Witt | Mike Witt | Neal Heaton | | 247 | 303 | -56 |
| 1985-06-19 | vs CAL | 62 | W 2-0 | 21-41 | 7 | 6,346 | Bert Blyleven | Jim Slaton | Bert Blyleven | Jim Slaton | | 249 | 303 | -54 |
| 1985-06-20 | vs CAL | 63 | L 0-4 | 21-42 | 7 | 6,346 | Don Schulze | Ron Romanick | Ron Romanick | Don Schulze | | 249 | 307 | -58 |
| 1985-06-21 | @ OAK | 64 | L 1-9 | 21-43 | 7 | 10,348 | Rick Behenna | Don Sutton | Don Sutton | Rick Behenna | | 250 | 316 | -66 |
| 1985-06-22 | @ OAK | 65 | L 4-6 | 21-44 | 7 | 16,740 | Vern Ruhle | Steve McCatty | Jay Howell | Jeff Barkley | | 254 | 322 | -68 |
| 1985-06-23 | @ OAK | 66 | L 3-9 | 21-45 | 7 | 24,222 | Neal Heaton | Chris Codiroli | Chris Codiroli | Neal Heaton | | 257 | 331 | -74 |
| 1985-06-24 | @ CAL | 67 | W 2-1 | 22-45 | 7 | 24,218 | Bert Blyleven | Jim Slaton | Bert Blyleven | Jim Slaton | | 259 | 332 | -73 |
| 1985-06-25 | @ CAL | 68 | L 3-7 | 22-46 | 7 | 25,610 | Roy Smith | Ron Romanick | Stew Cliburn | Neal Heaton | | 262 | 339 | -77 |
| 1985-06-26 | @ CAL | 69 | L 6-10 | 22-47 | 7 | 28,768 | Vern Ruhle | Kirk McCaskill | Luis Sanchez | Jeff Barkley | | 268 | 349 | -81 |
| 1985-06-28 | @ SEA | 70 | L 6-8 | 22-48 | 7 | 14,808 | Neal Heaton | Bill Swift | Roy Thomas | Jeff Barkley | Ed Nunez | 274 | 357 | -83 |
| 1985-06-29 | @ SEA | 71 | L 2-3 | 22-49 | 7 | 24,428 | Bert Blyleven | Mike Moore | Mike Moore | Bert Blyleven | Ed Nunez | 276 | 360 | -84 |
| 1985-06-30 | @ SEA | 72 | W 7-3 | 23-49 | 7 | 11,401 | Roy Smith | Matt Young | Rich Thompson | Matt Young | Tom Waddell | 283 | 363 | -80 |
| 1985-07-01 | @ MIN | 73 | W 5-2 | 24-49 | 7 | 22,729 | Vern Ruhle | Ken Schrom | Vern Ruhle | Ken Schrom | Jeff Barkley | 288 | 365 | -77 |
| 1985-07-02 | @ MIN | 74 | L 7-8 | 24-50 | 7 | 14,817 | Jerry Reed | Frank Viola | Frank Eufemia | Tom Waddell | Pete Filson | 295 | 373 | -78 |
| 1985-07-03 | @ MIN | 75 | L 0-7 | 24-51 | 7 | 22,834 | Neal Heaton | Mike Smithson | Mike Smithson | Neal Heaton | | 295 | 380 | -85 |
| 1985-07-04 | vs CHA | 76 | L 0-5 | 24-52 | 7 | 30,167 | Bert Blyleven | Britt Burns | Britt Burns | Bert Blyleven | | 295 | 385 | -90 |
| 1985-07-05 | vs CHA | 77 | L 3-8 | 24-53 | 7 | 6,025 | Jerry Reed | Tom Seaver | Tom Seaver | Jerry Reed | | 298 | 393 | -95 |
| 1985-07-06 | vs CHA | 78 | L 4-6 | 24-54 | 7 | 8,030 | Vern Ruhle | Floyd Bannister | Bob James | Rich Thompson | | 302 | 399 | -97 |
| 1985-07-07 | vs CHA | 79 | W 10-3 | 25-54 | 7 | 9,705 | Ramon Romero | Tim Lollar | Tom Waddell | Tim Lollar | | 312 | 402 | -90 |
| 1985-07-08 | vs TEX | 80 | W 4-0 | 26-54 | 7 | 4,142 | Neal Heaton | Mike Mason | Neal Heaton | Mike Mason | | 316 | 402 | -86 |
| 1985-07-09 | vs TEX | 81 | W 7-2 | 27-54 | 7 | 5,041 | Bert Blyleven | Burt Hooton | Bert Blyleven | Burt Hooton | | 323 | 404 | -81 |
| 1985-07-10 | vs TEX | 82 | L 1-4 | 27-55 | 7 | 4,878 | Jerry Reed | Charlie Hough | Charlie Hough | Jerry Reed | | 324 | 408 | -84 |
| 1985-07-11 | vs KCA | 83 | L 0-1 | 27-56 | 7 | 5,256 | Vern Ruhle | Danny Jackson | Danny Jackson | Vern Ruhle | | 324 | 409 | -85 |
| 1985-07-12 | vs KCA | 84 | W 5-4 | 28-56 | 7 | 8,058 | Ramon Romero | Charlie Leibrandt | Tom Waddell | Dan Quisenberry | | 329 | 413 | -84 |
| 1985-07-13 | vs KCA | 85 | L 1-5 | 28-57 | 7 | 12,794 | Bert Blyleven | Bret Saberhagen | Bret Saberhagen | Bert Blyleven | | 330 | 418 | -88 |
| 1985-07-14 | vs KCA | 86 | L 5-9 | 28-58 | 7 | 25,466 | Neal Heaton | Buddy Black | Buddy Black | Neal Heaton | Dan Quisenberry | 335 | 427 | -92 |
| 1985-07-18 | @ CHA | 87 | L 0-10 | 28-59 | 7 | 25,410 | Vern Ruhle | Britt Burns | Britt Burns | Vern Ruhle | | 335 | 437 | -102 |
| 1985-07-19 | @ CHA | 88 | L 0-1 | 28-60 | 7 | 26,459 | Bert Blyleven | Tom Seaver | Tom Seaver | Bert Blyleven | | 335 | 438 | -103 |
| 1985-07-20 | @ CHA | 89 | L 6-8 | 28-61 | 7 | 28,120 | Ramon Romero | Floyd Bannister | Juan Agosto | Bryan Clark | | 341 | 446 | -105 |
| 1985-07-21 | @ CHA | 90 | W 4-3 | 29-61 | 7 | 19,374 | Jerry Reed | Bill Long | Rich Thompson | Dan Spillner | | 345 | 449 | -104 |
| 1985-07-22 | @ TEX | 91 | L 1-2 | 29-62 | 7 | 9,756 | Vern Ruhle | Chris Welsh | Greg Harris | Vern Ruhle | | 346 | 451 | -105 |
| 1985-07-23 | @ TEX | 92 | L 4-8 | 29-63 | 7 | 8,985 | Neal Heaton | Charlie Hough | Charlie Hough | Neal Heaton | Dave Rozema | 350 | 459 | -109 |
| 1985-07-24 | @ TEX | 93 | W 8-4 | 30-63 | 7 | 17,235 | Bert Blyleven | Burt Hooton | Bert Blyleven | Burt Hooton | | 358 | 463 | -105 |
| 1985-07-26 | @ KCA | 94 | L 1-7 | 30-64 | 7 | 27,860 | Ramon Romero | Danny Jackson | Danny Jackson | Ramon Romero | | 359 | 470 | -111 |
| 1985-07-27 | @ KCA | 95 | L 3-6 | 30-65 | 7 | 33,473 | Jerry Reed | Buddy Black | Buddy Black | Jerry Reed | Dan Quisenberry | 362 | 476 | -114 |
| 1985-07-28 | @ KCA | 96 | L 4-7 | 30-66 | 7 | 38,352 | Vern Ruhle | Mark Gubicza | Mark Gubicza | Vern Ruhle | Dan Quisenberry | 366 | 483 | -117 |
| 1985-07-29 | vs NYA | 97 | L 2-8 | 30-67 | 7 | 15,042 | Bert Blyleven | Ed Whitson | Ed Whitson | Bert Blyleven | Dave Righetti | 368 | 491 | -123 |
| 1985-07-30 | vs NYA | 98 | L 5-8 | 31-68 | 7 | 0 | Neal Heaton | Joe Cowley | Joe Cowley | Rich Thompson | | 373 | 499 | -126 |
| 1985-07-30 | vs NYA | 99 | W 3-2 | 31-68 | 7 | 18,271 | Ramon Romero | Bob Shirley | Ramon Romero | Bob Shirley | Rich Thompson | 376 | 501 | -125 |
| 1985-07-31 | vs NYA | 100 | W 6-5 | 32-68 | 7 | 7,593 | Tom Waddell | Ron Guidry | Tom Waddell | Ron Guidry | Rich Thompson | 382 | 506 | -124 |
| 1985-08-01 | vs NYA | 101 | W 9-1 | 33-68 | 7 | 8,294 | Roy Smith | Phil Niekro | Roy Smith | Phil Niekro | | 391 | 507 | -116 |
| 1985-08-02 | vs BAL | 102 | L 6-8 | 33-69 | 7 | 8,067 | Vern Ruhle | Scott McGregor | Sammy Stewart | Rich Thompson | | 397 | 515 | -118 |
| 1985-08-03 | vs BAL | 103 | W 10-4 | 34-69 | 7 | 9,441 | Curt Wardle | Mike Boddicker | Curt Wardle | Mike Boddicker | | 407 | 519 | -112 |
| 1985-08-04 | vs BAL | 104 | L 4-5 | 34-70 | 7 | 12,252 | Neal Heaton | Mike Flanagan | Dennis Martinez | Rich Thompson | | 411 | 524 | -113 |
| 1985-08-08 | @ NYA | 105 | L 1-8 | 34-72 | 7 | 0 | Curt Wardle | Marty Bystrom | Marty Bystrom | Curt Wardle | | 412 | 532 | -120 |
| 1985-08-08 | @ NYA | 106 | L 6-7 | 34-72 | 7 | 25,692 | Ramon Romero | Phil Niekro | Brian Fisher | Jerry Reed | Dave Righetti | 418 | 539 | -121 |
| 1985-08-09 | vs DET | 107 | W 4-2 | 35-72 | 7 | 18,050 | Tom Waddell | Jack Morris | Jamie Easterly | Guillermo Hernandez | Rich Thompson | 422 | 541 | -119 |
| 1985-08-10 | vs DET | 108 | L 4-5 | 35-73 | 7 | 15,069 | Roy Smith | Walt Terrell | Guillermo Hernandez | Vern Ruhle | | 426 | 546 | -120 |
| 1985-08-11 | vs DET | 109 | W 7-2 | 36-73 | 7 | 13,475 | Neal Heaton | Randy O'Neal | Neal Heaton | Randy O'Neal | | 433 | 548 | -115 |
| 1985-08-12 | @ BAL | 110 | W 8-5 | 37-73 | 7 | 18,011 | Curt Wardle | Scott McGregor | Curt Wardle | Scott McGregor | Jerry Reed | 441 | 553 | -112 |
| 1985-08-13 | @ BAL | 111 | L 4-8 | 37-74 | 7 | 18,272 | Ramon Romero | Mike Boddicker | Don Aase | Vern Ruhle | | 445 | 561 | -116 |
| 1985-08-14 | @ BAL | 112 | L 4-8 | 37-75 | 7 | 15,814 | Bryan Clark | Mike Flanagan | Mike Flanagan | Bryan Clark | Nate Snell | 449 | 569 | -120 |
| 1985-08-15 | @ DET | 113 | W 7-6 | 38-75 | 7 | 23,542 | Roy Smith | Walt Terrell | Curt Wardle | Guillermo Hernandez | Jerry Reed | 456 | 575 | -119 |
| 1985-08-16 | @ DET | 114 | L 2-3 | 38-76 | 7 | 27,044 | Neal Heaton | Juan Berenguer | Aurelio Lopez | Neal Heaton | | 458 | 578 | -120 |
| 1985-08-17 | @ DET | 115 | L 5-7 | 38-77 | 7 | 32,723 | Curt Wardle | Frank Tanana | Frank Tanana | Curt Wardle | Randy O'Neal | 463 | 585 | -122 |
| 1985-08-18 | @ DET | 116 | L 0-4 | 38-78 | 7 | 31,148 | Ramon Romero | Dan Petry | Dan Petry | Ramon Romero | Guillermo Hernandez | 463 | 589 | -126 |
| 1985-08-19 | vs TOR | 117 | W 5-3 | 39-78 | 7 | 6,280 | Tom Waddell | Dave Stieb | Tom Waddell | Dave Stieb | | 468 | 592 | -124 |
| 1985-08-20 | vs TOR | 118 | L 2-3 | 39-79 | 7 | 7,005 | Roy Smith | Jimmy Key | Jimmy Key | Roy Smith | Tom Henke | 470 | 595 | -125 |
| 1985-08-21 | vs TOR | 119 | W 5-2 | 40-79 | 7 | 6,342 | Neal Heaton | Doyle Alexander | Neal Heaton | Doyle Alexander | | 475 | 597 | -122 |
| 1985-08-23 | vs MIL | 120 | W 10-5 | 41-79 | 7 | 6,292 | Curt Wardle | Jaime Cocanower | Curt Wardle | Jaime Cocanower | Vern Ruhle | 485 | 602 | -117 |
| 1985-08-25 | vs MIL | 121 | W 6-2 | 43-79 | 7 | 0 | Tom Waddell | Moose Haas | Tom Waddell | Moose Haas | | 491 | 604 | -113 |
| 1985-08-25 | vs MIL | 122 | W 2-0 | 43-79 | 7 | 7,789 | Ramon Romero | Danny Darwin | Ramon Romero | Danny Darwin | Bryan Clark | 493 | 604 | -111 |
| 1985-08-26 | vs MIL | 123 | W 4-3 | 44-80 | 7 | 0 | Neal Heaton | Teddy Higuera | Neal Heaton | Bob Gibson | | 497 | 607 | -110 |
| 1985-08-26 | vs MIL | 124 | L 3-8 | 44-80 | 7 | 4,205 | Roy Smith | Ray Burris | Ray Burris | Roy Smith | Rollie Fingers | 500 | 615 | -115 |
| 1985-08-27 | vs BOS | 125 | W 6-2 | 45-80 | 7 | 5,107 | Curt Wardle | Mike Trujillo | Curt Wardle | Mike Trujillo | Vern Ruhle | 506 | 617 | -111 |
| 1985-08-28 | vs BOS | 126 | W 7-4 | 46-80 | 7 | 5,464 | Jamie Easterly | Tim Lollar | Jamie Easterly | Tim Lollar | Jerry Reed | 513 | 621 | -108 |
| 1985-08-29 | vs BOS | 127 | L 2-17 | 46-81 | 7 | 6,110 | Ramon Romero | Bruce Hurst | Bruce Hurst | Ramon Romero | | 515 | 638 | -123 |
| 1985-08-30 | @ MIL | 128 | L 6-9 | 46-82 | 7 | 10,562 | Tom Waddell | Moose Haas | Moose Haas | Tom Waddell | | 521 | 647 | -126 |
| 1985-08-31 | @ MIL | 129 | L 8-10 | 46-83 | 7 | 10,780 | Neal Heaton | Teddy Higuera | Teddy Higuera | Neal Heaton | Bob Gibson | 529 | 657 | -128 |
| 1985-09-01 | @ MIL | 130 | W 11-4 | 47-83 | 7 | 11,475 | Roy Smith | Ray Burris | Dave Von Ohlen | Ray Burris | | 540 | 661 | -121 |
| 1985-09-02 | @ TOR | 131 | L 2-3 | 47-84 | 7 | 31,239 | Curt Wardle | Dave Stieb | Dave Stieb | Curt Wardle | Tom Henke | 542 | 664 | -122 |
| 1985-09-04 | @ TOR | 132 | W 5-4 | 48-84 | 7 | 25,361 | Tom Waddell | Jimmy Key | Bryan Clark | Tom Henke | Rich Thompson | 547 | 668 | -121 |
| 1985-09-05 | @ BOS | 133 | L 6-13 | 49-85 | 7 | 0 | Neal Heaton | Oil Can Boyd | Oil Can Boyd | Neal Heaton | | 553 | 681 | -128 |
| 1985-09-05 | @ BOS | 134 | W 9-5 | 49-85 | 7 | 16,989 | Jamie Easterly | Bob Ojeda | Jamie Easterly | Bob Ojeda | Jerry Reed | 562 | 686 | -124 |
| 1985-09-07 | @ BOS | 135 | L 9-11 | 49-87 | 7 | 0 | Roy Smith | Mike Trujillo | Bruce Kison | Jerry Reed | Steve Crawford | 571 | 697 | -126 |
| 1985-09-07 | @ BOS | 136 | L 4-7 | 49-87 | 7 | 19,953 | Curt Wardle | Al Nipper | Al Nipper | Curt Wardle | Steve Crawford | 575 | 704 | -129 |
| 1985-09-08 | @ BOS | 137 | L 1-8 | 49-88 | 7 | 18,511 | Neal Heaton | Tim Lollar | Tim Lollar | Neal Heaton | | 576 | 712 | -136 |
| 1985-09-09 | @ SEA | 138 | L 7-8 | 49-89 | 7 | 6,614 | Tom Waddell | Mark Langston | Dave Tobik | Rich Thompson | | 583 | 720 | -137 |
| 1985-09-10 | @ SEA | 139 | W 8-5 | 50-89 | 7 | 4,873 | Jamie Easterly | Frank Wills | Bryan Clark | Frank Wills | Jerry Reed | 591 | 725 | -134 |
| 1985-09-11 | @ SEA | 140 | L 5-9 | 50-90 | 7 | 5,367 | Roy Smith | Mike Moore | Mike Moore | Roy Smith | | 596 | 734 | -138 |
| 1985-09-13 | vs MIN | 141 | W 3-2 | 51-91 | 7 | 0 | Curt Wardle | Mark Portugal | Curt Wardle | Mark Portugal | Jerry Reed | 599 | 736 | -137 |
| 1985-09-13 | vs MIN | 142 | L 1-3 | 51-91 | 7 | 4,431 | Don Schulze | Frank Viola | Frank Viola | Don Schulze | Ron Davis | 600 | 739 | -139 |
| 1985-09-14 | vs MIN | 143 | W 11-9 | 52-92 | 7 | 0 | Tom Waddell | John Butcher | Tom Waddell | John Butcher | Jerry Reed | 611 | 748 | -137 |
| 1985-09-14 | vs MIN | 144 | L 3-5 | 52-92 | 7 | 5,218 | Neal Heaton | Dennis Burtt | Dennis Burtt | Rich Thompson | Ron Davis | 614 | 753 | -139 |
| 1985-09-15 | vs MIN | 145 | L 2-5 | 52-93 | 7 | 6,010 | Roy Smith | Bert Blyleven | Bert Blyleven | Roy Smith | Ron Davis | 616 | 758 | -142 |
| 1985-09-16 | @ NYA | 146 | W 9-5 | 53-93 | 7 | 15,320 | Jamie Easterly | Joe Cowley | Jerry Reed | Brian Fisher | | 625 | 763 | -138 |
| 1985-09-17 | vs OAK | 147 | W 15-8 | 54-93 | 7 | 3,262 | Curt Wardle | Tim Birtsas | Curt Wardle | Tim Birtsas | Bryan Clark | 640 | 771 | -131 |
| 1985-09-18 | vs OAK | 148 | L 0-1 | 54-94 | 7 | 3,287 | Don Schulze | Jose Rijo | Jose Rijo | Don Schulze | Jay Howell | 640 | 772 | -132 |
| 1985-09-20 | @ CAL | 149 | L 5-7 | 54-95 | 7 | 30,821 | Tom Waddell | Ron Romanick | Doug Corbett | Dave Von Ohlen | Donnie Moore | 645 | 779 | -134 |
| 1985-09-21 | @ CAL | 150 | L 3-12 | 54-96 | 7 | 29,219 | Neal Heaton | Kirk McCaskill | Kirk McCaskill | Neal Heaton | | 648 | 791 | -143 |
| 1985-09-22 | @ CAL | 151 | L 9-10 | 54-97 | 7 | 47,895 | Jamie Easterly | Mike Witt | Stew Cliburn | Bryan Clark | | 657 | 801 | -144 |
| 1985-09-23 | @ OAK | 152 | L 7-8 | 54-98 | 7 | 6,514 | Curt Wardle | Jose Rijo | Jose Rijo | Curt Wardle | Jay Howell | 664 | 809 | -145 |
| 1985-09-24 | @ OAK | 153 | L 8-10 | 54-99 | 7 | 6,584 | Don Schulze | Curt Young | Rick Langford | Vern Ruhle | Jay Howell | 672 | 819 | -147 |
| 1985-09-25 | @ OAK | 154 | W 7-2 | 55-99 | 7 | 6,158 | Keith Creel | Tommy John | Keith Creel | Tommy John | | 679 | 821 | -142 |
| 1985-09-27 | vs CAL | 155 | W 7-3 | 56-99 | 7 | 5,695 | Neal Heaton | Mike Witt | Neal Heaton | Mike Witt | Vern Ruhle | 686 | 824 | -138 |
| 1985-09-28 | vs CAL | 156 | W 7-5 | 57-99 | 7 | 6,673 | Jamie Easterly | Don Sutton | Jerry Reed | Stew Cliburn | | 693 | 829 | -136 |
| 1985-09-29 | vs CAL | 157 | L 3-9 | 57-100 | 7 | 11,502 | Curt Wardle | Kirk McCaskill | Kirk McCaskill | Curt Wardle | | 696 | 838 | -142 |
| 1985-10-01 | vs SEA | 158 | W 9-3 | 58-100 | 7 | 3,919 | Don Schulze | Frank Wills | Don Schulze | Frank Wills | Jerry Reed | 705 | 841 | -136 |
| 1985-10-02 | vs SEA | 159 | W 12-2 | 59-100 | 7 | 5,179 | Keith Creel | Mike Moore | Keith Creel | Mike Moore | | 717 | 843 | -126 |
| 1985-10-04 | @ MIN | 160 | W 8-6 | 60-100 | 7 | 30,451 | Neal Heaton | John Butcher | Jerry Reed | Dennis Burtt | | 725 | 849 | -124 |
| 1985-10-05 | @ MIN | 161 | L 2-8 | 60-101 | 7 | 8,806 | Jamie Easterly | Bert Blyleven | Bert Blyleven | Jamie Easterly | | 727 | 857 | -130 |
| 1985-10-06 | @ MIN | 162 | L 2-4 | 60-102 | 7 | 10,385 | Don Schulze | Mike Smithson | Mike Smithson | Don Schulze | | 729 | 861 | -132 |