| 1985-04-09 | @ NYN | 1 | L 5-6 | 0-1 | 6 | 46,781 | Joaquin Andujar | Dwight Gooden | Tom Gorman | Neil Allen | | 5 | 6 | -1 |
| 1985-04-11 | @ NYN | 2 | L 1-2 | 0-2 | 6 | 18,864 | John Tudor | Ron Darling | Roger McDowell | Andy Hassler | | 6 | 8 | -2 |
| 1985-04-12 | @ PIT | 3 | L 4-6 | 0-3 | 6 | 47,335 | Kurt Kepshire | Larry McWilliams | Don Robinson | Kurt Kepshire | John Candelaria | 10 | 14 | -4 |
| 1985-04-13 | @ PIT | 4 | L 3-4 | 0-4 | 6 | 9,171 | Danny Cox | Lee Tunnell | John Candelaria | Bill Campbell | | 13 | 18 | -5 |
| 1985-04-14 | @ PIT | 5 | W 10-4 | 1-4 | 6 | 12,483 | Joaquin Andujar | Rick Rhoden | Joaquin Andujar | Rick Rhoden | | 23 | 22 | 1 |
| 1985-04-15 | vs MON | 6 | W 6-1 | 2-4 | 5 | 42,986 | Bob Forsch | Bill Gullickson | Bob Forsch | Bill Gullickson | | 29 | 23 | 6 |
| 1985-04-17 | vs MON | 7 | L 1-2 | 2-5 | 5 | 20,145 | John Tudor | Joe Hesketh | Joe Hesketh | John Tudor | Jeff Reardon | 30 | 25 | 5 |
| 1985-04-18 | vs MON | 8 | L 1-7 | 2-6 | 5 | 19,953 | Kurt Kepshire | Steve Rogers | Steve Rogers | Kurt Kepshire | | 31 | 32 | -1 |
| 1985-04-19 | vs PIT | 9 | W 5-4 | 3-6 | 5 | 30,510 | Joaquin Andujar | Rick Rhoden | Joaquin Andujar | John Candelaria | Neil Allen | 36 | 36 | 0 |
| 1985-04-20 | vs PIT | 10 | W 4-3 | 4-6 | 4 | 32,978 | Danny Cox | Lee Tunnell | Danny Cox | Lee Tunnell | Neil Allen | 40 | 39 | 1 |
| 1985-04-21 | vs PIT | 11 | W 6-0 | 5-6 | 4 | 28,880 | Bob Forsch | Jose DeLeon | Bob Forsch | Jose DeLeon | | 46 | 39 | 7 |
| 1985-04-22 | vs NYN | 12 | L 6-7 | 5-7 | 4 | 16,324 | John Tudor | Calvin Schiraldi | Calvin Schiraldi | John Tudor | Jesse Orosco | 52 | 46 | 6 |
| 1985-04-23 | vs NYN | 13 | W 8-3 | 6-7 | 4 | 13,028 | Kurt Kepshire | Bruce Berenyi | Kurt Kepshire | Tom Gorman | | 60 | 49 | 11 |
| 1985-04-24 | vs NYN | 14 | W 5-1 | 7-7 | 4 | 29,282 | Joaquin Andujar | Dwight Gooden | Joaquin Andujar | Dwight Gooden | | 65 | 50 | 15 |
| 1985-04-25 | @ MON | 15 | L 2-4 | 7-8 | 4 | 10,203 | Danny Cox | Bill Gullickson | Bill Gullickson | Danny Cox | Jeff Reardon | 67 | 54 | 13 |
| 1985-04-26 | @ MON | 16 | L 5-10 | 7-9 | 4 | 10,264 | Bob Forsch | David Palmer | David Palmer | Bob Forsch | | 72 | 64 | 8 |
| 1985-04-27 | @ MON | 17 | L 3-8 | 7-10 | 4 | 15,171 | John Tudor | Joe Hesketh | Joe Hesketh | John Tudor | Bert Roberge | 75 | 72 | 3 |
| 1985-04-28 | @ MON | 18 | L 3-5 | 7-11 | 4 | 14,426 | Kurt Kepshire | Steve Rogers | Steve Rogers | Kurt Kepshire | Jeff Reardon | 78 | 77 | 1 |
| 1985-04-30 | vs LAN | 19 | W 6-1 | 8-11 | 5 | 20,380 | Joaquin Andujar | Jerry Reuss | Joaquin Andujar | Jerry Reuss | | 84 | 78 | 6 |
| 1985-05-01 | vs LAN | 20 | L 1-2 | 8-12 | 5 | 14,324 | Danny Cox | Orel Hershiser | Ken Howell | Neil Allen | Tom Niedenfuer | 85 | 80 | 5 |
| 1985-05-03 | vs SFN | 21 | W 8-1 | 9-12 | 5 | 32,441 | John Tudor | Mike Krukow | John Tudor | Mike Krukow | | 93 | 81 | 12 |
| 1985-05-04 | vs SFN | 22 | W 6-4 | 10-12 | 5 | 41,410 | Kurt Kepshire | Atlee Hammaker | Kurt Kepshire | Atlee Hammaker | Jeff Lahti | 99 | 85 | 14 |
| 1985-05-05 | vs SFN | 23 | L 0-5 | 10-13 | 5 | 31,322 | Joaquin Andujar | Dave LaPoint | Dave LaPoint | Joaquin Andujar | | 99 | 90 | 9 |
| 1985-05-06 | vs SDN | 24 | W 5-2 | 11-13 | 4 | 28,260 | Danny Cox | Eric Show | Danny Cox | Eric Show | Jeff Lahti | 104 | 92 | 12 |
| 1985-05-07 | vs SDN | 25 | L 2-12 | 11-14 | 4 | 18,682 | Bob Forsch | Dave Dravecky | Dave Dravecky | Bob Forsch | | 106 | 104 | 2 |
| 1985-05-08 | @ LAN | 26 | L 2-5 | 11-15 | 4 | 33,748 | John Tudor | Rick Honeycutt | Rick Honeycutt | John Tudor | Ken Howell | 108 | 109 | -1 |
| 1985-05-09 | @ LAN | 27 | W 5-4 | 12-15 | 4 | 37,775 | Kurt Kepshire | Fernando Valenzuela | Neil Allen | Ken Howell | Ken Dayley | 113 | 113 | 0 |
| 1985-05-10 | @ SFN | 28 | W 9-3 | 13-15 | 4 | 12,900 | Joaquin Andujar | Dave LaPoint | Joaquin Andujar | Dave LaPoint | Bill Campbell | 122 | 116 | 6 |
| 1985-05-11 | @ SFN | 29 | W 9-4 | 14-15 | 4 | 16,154 | Danny Cox | Bill Laskey | Danny Cox | Bill Laskey | | 131 | 120 | 11 |
| 1985-05-12 | @ SFN | 30 | L 4-5 | 14-16 | 4 | 19,614 | Bob Forsch | Jim Gott | Scott Garrelts | Neil Allen | | 135 | 125 | 10 |
| 1985-05-14 | @ SDN | 31 | L 2-6 | 14-17 | 4 | 23,904 | John Tudor | Andy Hawkins | Andy Hawkins | John Tudor | Mark Thurmond | 137 | 131 | 6 |
| 1985-05-15 | @ SDN | 32 | W 14-4 | 15-17 | 4 | 27,368 | Joaquin Andujar | LaMarr Hoyt | Joaquin Andujar | LaMarr Hoyt | | 151 | 135 | 16 |
| 1985-05-17 | @ HOU | 33 | W 8-6 | 16-17 | 4 | 14,501 | Danny Cox | Bob Knepper | Bill Campbell | Jeff Calhoun | Ken Dayley | 159 | 141 | 18 |
| 1985-05-18 | @ HOU | 34 | L 5-6 | 16-18 | 4 | 39,828 | Kurt Kepshire | Nolan Ryan | Nolan Ryan | Kurt Kepshire | Mark Ross | 164 | 147 | 17 |
| 1985-05-19 | @ HOU | 35 | L 3-7 | 16-19 | 4 | 15,652 | John Tudor | Ron Mathis | Ron Mathis | John Tudor | Bill Dawley | 167 | 154 | 13 |
| 1985-05-20 | vs ATL | 36 | W 14-0 | 17-19 | 4 | 25,112 | Joaquin Andujar | Zane Smith | Joaquin Andujar | Zane Smith | | 181 | 154 | 27 |
| 1985-05-21 | vs ATL | 37 | W 6-3 | 18-19 | 4 | 27,541 | Danny Cox | Len Barker | Danny Cox | Len Barker | Ricky Horton | 187 | 157 | 30 |
| 1985-05-22 | vs ATL | 38 | W 5-3 | 19-19 | 4 | 28,729 | Kurt Kepshire | Rick Mahler | Bob Forsch | Rick Mahler | Ken Dayley | 192 | 160 | 32 |
| 1985-05-24 | @ CIN | 39 | L 6-7 | 19-20 | 4 | 20,665 | John Tudor | Mario Soto | John Franco | Ricky Horton | | 198 | 167 | 31 |
| 1985-05-25 | @ CIN | 40 | W 6-4 | 20-20 | 4 | 24,846 | Joaquin Andujar | Jay Tibbs | Joaquin Andujar | Jay Tibbs | Ken Dayley | 204 | 171 | 33 |
| 1985-05-26 | @ CIN | 41 | W 7-2 | 21-20 | 4 | 21,349 | Danny Cox | John Stuper | Danny Cox | John Stuper | | 211 | 173 | 38 |
| 1985-05-28 | @ ATL | 42 | W 9-3 | 22-20 | 4 | 9,856 | Bob Forsch | Len Barker | Bob Forsch | Zane Smith | Jeff Lahti | 220 | 176 | 44 |
| 1985-05-29 | @ ATL | 43 | L 3-5 | 22-21 | 4 | 8,557 | John Tudor | Steve Bedrosian | Steve Bedrosian | John Tudor | Bruce Sutter | 223 | 181 | 42 |
| 1985-05-30 | @ ATL | 44 | W 6-0 | 23-21 | 4 | 13,503 | Joaquin Andujar | Rick Mahler | Joaquin Andujar | Rick Mahler | Bill Campbell | 229 | 181 | 48 |
| 1985-05-31 | vs CIN | 45 | W 5-0 | 24-21 | 4 | 38,910 | Danny Cox | John Stuper | Danny Cox | John Stuper | | 234 | 181 | 53 |
| 1985-06-01 | vs CIN | 46 | L 3-9 | 24-22 | 4 | 35,586 | Kurt Kepshire | Tom Browning | Tom Browning | Kurt Kepshire | Tom Hume | 237 | 190 | 47 |
| 1985-06-02 | vs CIN | 47 | L 3-8 | 24-23 | 4 | 33,774 | Bob Forsch | Jay Tibbs | Jay Tibbs | Bob Forsch | | 240 | 198 | 42 |
| 1985-06-03 | vs HOU | 48 | W 9-5 | 25-23 | 4 | 18,891 | John Tudor | Nolan Ryan | John Tudor | Nolan Ryan | Ken Dayley | 249 | 203 | 46 |
| 1985-06-04 | vs HOU | 49 | W 6-1 | 26-23 | 4 | 23,203 | Joaquin Andujar | Joe Niekro | Joaquin Andujar | Joe Niekro | | 255 | 204 | 51 |
| 1985-06-05 | vs HOU | 50 | L 3-8 | 26-24 | 4 | 23,998 | Danny Cox | Bob Knepper | Bob Knepper | Danny Cox | Frank DiPino | 258 | 212 | 46 |
| 1985-06-07 | @ NYN | 51 | W 7-2 | 27-24 | 4 | 34,490 | Kurt Kepshire | Ron Darling | Bill Campbell | Doug Sisk | | 265 | 214 | 51 |
| 1985-06-08 | @ NYN | 52 | W 1-0 | 28-24 | 4 | 36,424 | John Tudor | Ed Lynch | John Tudor | Tom Gorman | | 266 | 214 | 52 |
| 1985-06-09 | @ NYN | 53 | L 1-6 | 29-25 | 4 | 0 | Bob Forsch | Dwight Gooden | Dwight Gooden | Bob Forsch | | 267 | 220 | 47 |
| 1985-06-09 | @ NYN | 54 | W 8-2 | 29-25 | 4 | 41,431 | Joaquin Andujar | Calvin Schiraldi | Joaquin Andujar | Calvin Schiraldi | | 275 | 222 | 53 |
| 1985-06-10 | @ PIT | 55 | W 6-1 | 30-25 | 4 | 5,557 | Danny Cox | Rick Rhoden | Danny Cox | Rick Rhoden | | 281 | 223 | 58 |
| 1985-06-11 | @ PIT | 56 | L 2-13 | 30-26 | 4 | 4,817 | Neil Allen | Rick Reuschel | Rick Reuschel | Neil Allen | | 283 | 236 | 47 |
| 1985-06-13 | @ PIT | 57 | W 2-1 | 31-26 | 4 | 4,833 | John Tudor | Larry McWilliams | John Tudor | Larry McWilliams | Jeff Lahti | 285 | 237 | 48 |
| 1985-06-14 | @ CHN | 58 | W 11-10 | 32-26 | 4 | 36,745 | Joaquin Andujar | Dick Ruthven | Joaquin Andujar | Dick Ruthven | Bob Forsch | 296 | 247 | 49 |
| 1985-06-15 | @ CHN | 59 | W 2-0 | 33-26 | 3 | 34,716 | Danny Cox | Ray Fontenot | Danny Cox | Ray Fontenot | | 298 | 247 | 51 |
| 1985-06-16 | @ CHN | 60 | W 5-2 | 34-26 | 3 | 36,262 | Kurt Kepshire | Dennis Eckersley | Kurt Kepshire | Dennis Eckersley | Bill Campbell | 303 | 249 | 54 |
| 1985-06-18 | vs PHI | 61 | W 6-2 | 35-26 | 3 | 34,089 | John Tudor | Steve Carlton | John Tudor | Steve Carlton | | 309 | 251 | 58 |
| 1985-06-19 | vs PHI | 62 | L 0-1 | 35-27 | 4 | 32,146 | Joaquin Andujar | Jerry Koosman | Jerry Koosman | Joaquin Andujar | Don Carman | 309 | 252 | 57 |
| 1985-06-20 | vs PHI | 63 | W 5-0 | 36-27 | 3 | 32,397 | Danny Cox | Kevin Gross | Danny Cox | Kevin Gross | | 314 | 252 | 62 |
| 1985-06-21 | vs CHN | 64 | W 7-5 | 37-27 | 2 | 46,005 | Kurt Kepshire | Dennis Eckersley | Kurt Kepshire | Dennis Eckersley | Jeff Lahti | 321 | 257 | 64 |
| 1985-06-22 | vs CHN | 65 | W 2-1 | 38-27 | 1 | 49,231 | Bob Forsch | Rick Sutcliffe | Ken Dayley | Lee Smith | | 323 | 258 | 65 |
| 1985-06-23 | vs CHN | 66 | W 7-0 | 39-27 | 1 | 45,881 | John Tudor | Dick Ruthven | John Tudor | Dick Ruthven | | 330 | 258 | 72 |
| 1985-06-25 | @ PHI | 67 | L 1-3 | 39-28 | 2 | 24,432 | Joaquin Andujar | Jerry Koosman | Jerry Koosman | Joaquin Andujar | | 331 | 261 | 70 |
| 1985-06-26 | @ PHI | 68 | L 4-6 | 39-29 | 2 | 22,213 | Danny Cox | John Denny | John Denny | Danny Cox | Kent Tekulve | 335 | 267 | 68 |
| 1985-06-27 | @ PHI | 69 | W 4-3 | 40-29 | 2 | 22,691 | Kurt Kepshire | Shane Rawley | Kurt Kepshire | Shane Rawley | Jeff Lahti | 339 | 270 | 69 |
| 1985-06-28 | vs NYN | 70 | W 3-2 | 41-29 | 2 | 45,929 | John Tudor | Ed Lynch | John Tudor | Ed Lynch | Ken Dayley | 342 | 272 | 70 |
| 1985-06-29 | vs NYN | 71 | W 6-0 | 42-29 | 1 | 47,891 | Joaquin Andujar | Rick Aguilera | Joaquin Andujar | Rick Aguilera | | 348 | 272 | 76 |
| 1985-06-30 | vs NYN | 72 | W 2-1 | 43-29 | 1 | 47,425 | Danny Cox | Dwight Gooden | Ken Dayley | Jesse Orosco | | 350 | 273 | 77 |
| 1985-07-01 | @ MON | 73 | L 2-3 | 43-30 | 1 | 22,781 | Kurt Kepshire | Floyd Youmans | Gary Lucas | Ricky Horton | | 352 | 276 | 76 |
| 1985-07-02 | @ MON | 74 | W 4-0 | 44-30 | 1 | 25,487 | John Tudor | David Palmer | John Tudor | David Palmer | | 356 | 276 | 80 |
| 1985-07-04 | vs LAN | 75 | W 3-2 | 45-30 | 1 | 38,394 | Joaquin Andujar | Rick Honeycutt | Joaquin Andujar | Ken Howell | | 359 | 278 | 81 |
| 1985-07-05 | vs LAN | 76 | L 1-4 | 45-31 | 1 | 39,296 | Danny Cox | Jerry Reuss | Tom Niedenfuer | Danny Cox | Ken Howell | 360 | 282 | 78 |
| 1985-07-06 | vs LAN | 77 | L 3-8 | 45-32 | 1 | 33,852 | Kurt Kepshire | Bob Welch | Bob Welch | Kurt Kepshire | | 363 | 290 | 73 |
| 1985-07-07 | vs LAN | 78 | W 7-1 | 46-32 | 1 | 36,313 | John Tudor | Orel Hershiser | John Tudor | Orel Hershiser | | 370 | 291 | 79 |
| 1985-07-08 | vs SFN | 79 | W 6-1 | 47-32 | 1 | 25,102 | Joaquin Andujar | Dave LaPoint | Joaquin Andujar | Dave LaPoint | | 376 | 292 | 84 |
| 1985-07-09 | vs SFN | 80 | W 3-1 | 48-32 | 1 | 25,019 | Danny Cox | Bill Laskey | Danny Cox | Bill Laskey | | 379 | 293 | 86 |
| 1985-07-10 | vs SFN | 81 | W 7-3 | 49-32 | 1 | 30,196 | Kurt Kepshire | Vida Blue | Kurt Kepshire | Vida Blue | Jeff Lahti | 386 | 296 | 90 |
| 1985-07-11 | vs SDN | 82 | W 6-0 | 50-32 | 1 | 32,805 | John Tudor | Mark Thurmond | John Tudor | Mark Thurmond | | 392 | 296 | 96 |
| 1985-07-12 | vs SDN | 83 | L 0-2 | 50-33 | 1 | 44,199 | Joaquin Andujar | LaMarr Hoyt | LaMarr Hoyt | Joaquin Andujar | Rich Gossage | 392 | 298 | 94 |
| 1985-07-13 | vs SDN | 84 | W 7-3 | 51-33 | 1 | 47,720 | Danny Cox | Ed Wojna | Danny Cox | Ed Wojna | Jeff Lahti | 399 | 301 | 98 |
| 1985-07-14 | vs SDN | 85 | W 2-1 | 52-33 | 1 | 38,509 | Kurt Kepshire | Eric Show | Kurt Kepshire | Dave Dravecky | Jeff Lahti | 401 | 302 | 99 |
| 1985-07-18 | @ LAN | 86 | L 1-2 | 52-34 | 1 | 46,484 | Joaquin Andujar | Orel Hershiser | Orel Hershiser | Bill Campbell | Tom Niedenfuer | 402 | 304 | 98 |
| 1985-07-19 | @ LAN | 87 | L 2-5 | 52-35 | 1 | 49,472 | Danny Cox | Bob Welch | Bob Welch | Danny Cox | | 404 | 309 | 95 |
| 1985-07-20 | @ LAN | 88 | L 0-3 | 52-36 | 1 | 48,582 | John Tudor | Fernando Valenzuela | Fernando Valenzuela | John Tudor | | 404 | 312 | 92 |
| 1985-07-21 | @ LAN | 89 | W 4-2 | 53-36 | 1 | 40,830 | Kurt Kepshire | Jerry Reuss | Jeff Lahti | Tom Niedenfuer | Bob Forsch | 408 | 314 | 94 |
| 1985-07-22 | @ SFN | 90 | W 4-3 | 54-36 | 1 | 5,954 | Joaquin Andujar | Dave LaPoint | Joaquin Andujar | Dave LaPoint | Jeff Lahti | 412 | 317 | 95 |
| 1985-07-23 | @ SFN | 91 | W 6-3 | 55-36 | 1 | 7,688 | Danny Cox | Mike Krukow | Danny Cox | Mike Krukow | | 418 | 320 | 98 |
| 1985-07-24 | @ SFN | 92 | W 4-0 | 56-36 | 1 | 11,012 | John Tudor | Jim Gott | John Tudor | Jim Gott | | 422 | 320 | 102 |
| 1985-07-25 | @ SDN | 93 | W 9-6 | 57-36 | 1 | 24,164 | Kurt Kepshire | Eric Show | Ken Dayley | Rich Gossage | Jeff Lahti | 431 | 326 | 105 |
| 1985-07-26 | @ SDN | 94 | W 2-1 | 58-36 | 1 | 28,811 | Joaquin Andujar | Dave Dravecky | Joaquin Andujar | Tim Stoddard | Ken Dayley | 433 | 327 | 106 |
| 1985-07-27 | @ SDN | 95 | L 0-2 | 58-37 | 1 | 32,132 | Danny Cox | Andy Hawkins | Andy Hawkins | Danny Cox | Rich Gossage | 433 | 329 | 104 |
| 1985-07-28 | @ SDN | 96 | W 4-2 | 59-37 | 1 | 38,762 | John Tudor | LaMarr Hoyt | John Tudor | LaMarr Hoyt | Jeff Lahti | 437 | 331 | 106 |
| 1985-07-30 | @ CHN | 97 | W 11-3 | 60-37 | 1 | 33,083 | Kurt Kepshire | Steve Engel | Kurt Kepshire | Steve Engel | | 448 | 334 | 114 |
| 1985-07-31 | @ CHN | 98 | L 2-5 | 60-38 | 1 | 31,417 | Joaquin Andujar | Ray Fontenot | Ray Fontenot | Joaquin Andujar | Lee Smith | 450 | 339 | 111 |
| 1985-08-01 | @ CHN | 99 | L 8-9 | 60-39 | 1 | 36,164 | Danny Cox | Scott Sanderson | George Frazier | Ken Dayley | | 458 | 348 | 110 |
| 1985-08-02 | vs PHI | 100 | W 3-2 | 61-39 | 1 | 47,805 | John Tudor | Charles Hudson | John Tudor | Charles Hudson | | 461 | 350 | 111 |
| 1985-08-03 | vs PHI | 101 | L 4-6 | 61-40 | 1 | 47,051 | Kurt Kepshire | Jerry Koosman | Don Carman | Jeff Lahti | Larry Andersen | 465 | 356 | 109 |
| 1985-08-04 | vs PHI | 102 | L 0-6 | 61-41 | 1 | 46,674 | Joaquin Andujar | Kevin Gross | Kevin Gross | Joaquin Andujar | | 465 | 362 | 103 |
| 1985-08-05 | vs PHI | 103 | L 1-9 | 61-42 | 2 | 36,689 | Danny Cox | Shane Rawley | Shane Rawley | Danny Cox | | 466 | 371 | 95 |
| 1985-08-08 | vs CHN | 104 | W 8-0 | 62-42 | 2 | 39,203 | John Tudor | Scott Sanderson | John Tudor | Scott Sanderson | | 474 | 371 | 103 |
| 1985-08-09 | @ PHI | 105 | W 5-4 | 63-42 | 2 | 25,194 | Joaquin Andujar | Charles Hudson | Joaquin Andujar | Charles Hudson | Jeff Lahti | 479 | 375 | 104 |
| 1985-08-10 | @ PHI | 106 | W 5-4 | 65-42 | 2 | 0 | Danny Cox | Jerry Koosman | Danny Cox | Jerry Koosman | Jeff Lahti | 484 | 379 | 105 |
| 1985-08-10 | @ PHI | 107 | W 13-4 | 65-42 | 2 | 37,321 | Kurt Kepshire | Kevin Gross | Ricky Horton | Kevin Gross | | 497 | 383 | 114 |
| 1985-08-11 | @ PHI | 108 | L 1-4 | 65-43 | 2 | 31,602 | Bob Forsch | Shane Rawley | Shane Rawley | Bob Forsch | | 498 | 387 | 111 |
| 1985-08-12 | vs PIT | 109 | W 8-1 | 66-43 | 2 | 24,516 | John Tudor | Jim Winn | John Tudor | Jim Winn | | 506 | 388 | 118 |
| 1985-08-13 | vs PIT | 110 | W 6-5 | 67-43 | 2 | 30,469 | Joaquin Andujar | Don Robinson | Joaquin Andujar | Don Robinson | Ken Dayley | 512 | 393 | 119 |
| 1985-08-15 | vs PIT | 111 | W 3-1 | 69-43 | 2 | 0 | Kurt Kepshire | Rick Reuschel | Kurt Kepshire | Rick Reuschel | Ken Dayley | 515 | 394 | 121 |
| 1985-08-15 | vs PIT | 112 | W 4-3 | 69-43 | 2 | 34,170 | Danny Cox | Bob Walk | Bill Campbell | Cecilio Guante | | 519 | 397 | 122 |
| 1985-08-16 | vs MON | 113 | W 6-1 | 70-43 | 1 | 40,873 | Bob Forsch | Bill Laskey | Bob Forsch | Bill Laskey | | 525 | 398 | 127 |
| 1985-08-17 | vs MON | 114 | L 4-5 | 70-44 | 2 | 45,093 | John Tudor | Floyd Youmans | Tim Burke | Bill Campbell | Gary Lucas | 529 | 403 | 126 |
| 1985-08-18 | vs MON | 115 | L 5-6 | 70-45 | 2 | 39,813 | Joaquin Andujar | Joe Hesketh | Gary Lucas | Joaquin Andujar | Jeff Reardon | 534 | 409 | 125 |
| 1985-08-20 | @ HOU | 116 | L 2-17 | 70-46 | 2 | 10,348 | Kurt Kepshire | Mike Scott | Mike Scott | Kurt Kepshire | | 536 | 426 | 110 |
| 1985-08-21 | @ HOU | 117 | W 7-4 | 71-46 | 2 | 14,164 | Danny Cox | Bob Knepper | Jeff Lahti | Dave Smith | | 543 | 430 | 113 |
| 1985-08-22 | @ HOU | 118 | W 2-1 | 72-46 | 2 | 14,555 | John Tudor | Joe Niekro | Ricky Horton | Jeff Calhoun | Ken Dayley | 545 | 431 | 114 |
| 1985-08-23 | @ ATL | 119 | W 6-2 | 73-46 | 1 | 19,958 | Joaquin Andujar | Craig McMurtry | Joaquin Andujar | Craig McMurtry | Jeff Lahti | 551 | 433 | 118 |
| 1985-08-24 | @ ATL | 120 | W 7-0 | 74-46 | 1 | 31,109 | Bob Forsch | Len Barker | Bob Forsch | Len Barker | | 558 | 433 | 125 |
| 1985-08-25 | @ ATL | 121 | W 5-2 | 75-46 | 1 | 14,711 | Kurt Kepshire | Rick Mahler | Kurt Kepshire | Rick Mahler | Bill Campbell | 563 | 435 | 128 |
| 1985-08-26 | @ CIN | 122 | W 3-0 | 76-46 | 1 | 28,071 | Danny Cox | Jay Tibbs | Danny Cox | Jay Tibbs | | 566 | 435 | 131 |
| 1985-08-27 | @ CIN | 123 | W 6-4 | 77-46 | 1 | 22,268 | John Tudor | Andy McGaffigan | Bill Campbell | Ted Power | Jeff Lahti | 572 | 439 | 133 |
| 1985-08-28 | @ CIN | 124 | L 6-7 | 77-47 | 1 | 21,049 | Joaquin Andujar | Mario Soto | Ted Power | Jeff Lahti | | 578 | 446 | 132 |
| 1985-08-30 | vs HOU | 125 | L 5-7 | 77-48 | 1 | 31,975 | Kurt Kepshire | Mike Scott | Mike Scott | Kurt Kepshire | Dave Smith | 583 | 453 | 130 |
| 1985-08-31 | vs HOU | 126 | L 1-3 | 77-49 | 1 | 38,387 | Danny Cox | Bob Knepper | Bob Knepper | Danny Cox | | 584 | 456 | 128 |
| 1985-09-01 | vs HOU | 127 | W 5-0 | 78-49 | 1 | 31,927 | John Tudor | Joe Niekro | John Tudor | Joe Niekro | | 589 | 456 | 133 |
| 1985-09-02 | vs CIN | 128 | L 1-4 | 78-50 | 1 | 29,026 | Joaquin Andujar | Tom Browning | Tom Browning | Joaquin Andujar | John Franco | 590 | 460 | 130 |
| 1985-09-03 | vs CIN | 129 | W 6-4 | 79-50 | 1 | 19,261 | Bob Forsch | Jay Tibbs | Jeff Lahti | Tom Hume | | 596 | 464 | 132 |
| 1985-09-04 | vs CIN | 130 | W 4-3 | 80-50 | 1 | 25,425 | Kurt Kepshire | Andy McGaffigan | Todd Worrell | Ron Robinson | | 600 | 467 | 133 |
| 1985-09-05 | vs CHN | 131 | W 6-1 | 81-50 | 1 | 33,693 | Danny Cox | Steve Engel | Danny Cox | Steve Engel | | 606 | 468 | 138 |
| 1985-09-06 | vs ATL | 132 | W 8-0 | 82-50 | 1 | 25,821 | John Tudor | Rick Mahler | John Tudor | Rick Mahler | | 614 | 468 | 146 |
| 1985-09-07 | vs ATL | 133 | L 1-3 | 82-51 | 1 | 38,091 | Joaquin Andujar | Steve Bedrosian | Steve Bedrosian | Joaquin Andujar | Bruce Sutter | 615 | 471 | 144 |
| 1985-09-08 | vs ATL | 134 | L 3-7 | 82-52 | 1 | 24,930 | Bob Forsch | Joe Johnson | Joe Johnson | Bob Forsch | | 618 | 478 | 140 |
| 1985-09-09 | vs CHN | 135 | L 1-3 | 82-53 | 2 | 32,808 | Kurt Kepshire | Ray Fontenot | Ray Fontenot | Kurt Kepshire | Ron Meridith | 619 | 481 | 138 |
| 1985-09-10 | @ NYN | 136 | L 4-5 | 82-54 | 2 | 50,195 | Danny Cox | Ron Darling | Ron Darling | Danny Cox | Roger McDowell | 623 | 486 | 137 |
| 1985-09-11 | @ NYN | 137 | W 1-0 | 83-54 | 2 | 52,616 | John Tudor | Dwight Gooden | John Tudor | Jesse Orosco | | 624 | 486 | 138 |
| 1985-09-12 | @ NYN | 138 | L 6-7 | 83-55 | 2 | 46,295 | Joaquin Andujar | Ed Lynch | Jesse Orosco | Ken Dayley | | 630 | 493 | 137 |
| 1985-09-13 | @ CHN | 139 | W 9-3 | 84-55 | 2 | 16,110 | Bob Forsch | Steve Trout | Bob Forsch | Steve Trout | Todd Worrell | 639 | 496 | 143 |
| 1985-09-14 | @ CHN | 140 | W 5-4 | 85-55 | 1 | 29,852 | Kurt Kepshire | Ray Fontenot | Bill Campbell | Lary Sorensen | Jeff Lahti | 644 | 500 | 144 |
| 1985-09-15 | @ CHN | 141 | W 5-1 | 86-55 | 1 | 28,430 | Danny Cox | Steve Engel | Danny Cox | Steve Engel | | 649 | 501 | 148 |
| 1985-09-16 | @ PIT | 142 | W 8-4 | 88-55 | 1 | 0 | John Tudor | Jose DeLeon | John Tudor | Jose DeLeon | Todd Worrell | 657 | 505 | 152 |
| 1985-09-16 | @ PIT | 143 | W 3-1 | 88-55 | 1 | 3,601 | Ricky Horton | Rick Rhoden | Pat Perry | Pat Clements | | 660 | 506 | 154 |
| 1985-09-17 | @ PIT | 144 | W 10-4 | 89-55 | 1 | 3,924 | Joaquin Andujar | Bob Kipper | Joaquin Andujar | Bob Kipper | | 670 | 510 | 160 |
| 1985-09-18 | @ PHI | 145 | W 7-0 | 90-55 | 1 | 17,354 | Bob Forsch | John Denny | Bob Forsch | John Denny | | 677 | 510 | 167 |
| 1985-09-19 | @ PHI | 146 | L 3-6 | 90-56 | 1 | 17,120 | Matt Keough | Dave Rucker | Dave Rucker | Matt Keough | Don Carman | 680 | 516 | 164 |
| 1985-09-20 | vs MON | 147 | W 5-3 | 91-56 | 1 | 33,788 | Danny Cox | Dan Schatzeder | Todd Worrell | Randy St. Claire | | 685 | 519 | 166 |
| 1985-09-21 | vs MON | 148 | W 7-6 | 92-56 | 1 | 32,788 | John Tudor | Bill Gullickson | Jeff Lahti | Bert Roberge | Todd Worrell | 692 | 525 | 167 |
| 1985-09-22 | vs MON | 149 | W 6-5 | 93-56 | 1 | 32,958 | Joaquin Andujar | Floyd Youmans | Ken Dayley | Jack O'Connor | | 698 | 530 | 168 |
| 1985-09-23 | vs PIT | 150 | W 5-4 | 94-56 | 1 | 17,611 | Bob Forsch | Bob Walk | Jeff Lahti | Cecilio Guante | Todd Worrell | 703 | 534 | 169 |
| 1985-09-24 | vs PIT | 151 | W 5-4 | 95-56 | 1 | 20,054 | Ricky Horton | Lee Tunnell | Ricky Horton | Lee Tunnell | Ken Dayley | 708 | 538 | 170 |
| 1985-09-25 | vs PHI | 152 | W 6-3 | 96-56 | 1 | 17,733 | Danny Cox | Charles Hudson | Danny Cox | Charles Hudson | Jeff Lahti | 714 | 541 | 173 |
| 1985-09-26 | vs PHI | 153 | W 5-0 | 97-56 | 1 | 23,598 | John Tudor | Kevin Gross | John Tudor | Kevin Gross | | 719 | 541 | 178 |
| 1985-09-28 | @ MON | 154 | L 0-2 | 98-57 | 1 | 0 | Joaquin Andujar | Bill Gullickson | Bill Gullickson | Joaquin Andujar | Jeff Reardon | 719 | 543 | 176 |
| 1985-09-28 | @ MON | 155 | W 4-2 | 98-57 | 1 | 15,512 | Bob Forsch | Floyd Youmans | Todd Worrell | Jeff Reardon | | 723 | 545 | 178 |
| 1985-09-29 | @ MON | 156 | L 5-7 | 98-58 | 1 | 20,577 | Ricky Horton | Dan Schatzeder | Gary Lucas | Ken Dayley | Jeff Reardon | 728 | 552 | 176 |
| 1985-10-01 | vs NYN | 157 | L 0-1 | 98-59 | 1 | 46,026 | John Tudor | Ron Darling | Jesse Orosco | Ken Dayley | | 728 | 553 | 175 |
| 1985-10-02 | vs NYN | 158 | L 2-5 | 98-60 | 1 | 47,333 | Joaquin Andujar | Dwight Gooden | Dwight Gooden | Joaquin Andujar | | 730 | 558 | 172 |
| 1985-10-03 | vs NYN | 159 | W 4-3 | 99-60 | 1 | 47,720 | Danny Cox | Rick Aguilera | Danny Cox | Rick Aguilera | Jeff Lahti | 734 | 561 | 173 |
| 1985-10-04 | vs CHN | 160 | W 4-2 | 100-60 | 1 | 40,618 | Bob Forsch | Dennis Eckersley | Bob Forsch | Dennis Eckersley | Todd Worrell | 738 | 563 | 175 |
| 1985-10-05 | vs CHN | 161 | W 7-1 | 101-60 | 1 | 44,825 | John Tudor | Steve Trout | John Tudor | Steve Trout | | 745 | 564 | 181 |
| 1985-10-06 | vs CHN | 162 | L 2-8 | 101-61 | 1 | 43,665 | Joaquin Andujar | Reggie Patterson | Reggie Patterson | Joaquin Andujar | | 747 | 572 | 175 |