| 1982-04-05 | @ CIN | 1 | W 3-2 | 1-0 | 1 | 51,894 | Doug Bird | Mario Soto | Doug Bird | Mario Soto | Guillermo Hernandez | 3 | 2 | 1 |
| 1982-04-07 | @ CIN | 2 | L 2-6 | 1-1 | 1 | 10,158 | Dickie Noles | Bruce Berenyi | Bruce Berenyi | Dickie Noles | Tom Hume | 5 | 8 | -3 |
| 1982-04-09 | vs NYN | 3 | W 5-0 | 2-1 | 2 | 26,712 | Fergie Jenkins | Mike Scott | Fergie Jenkins | Mike Scott | Lee Smith | 10 | 8 | 2 |
| 1982-04-10 | vs NYN | 4 | L 5-9 | 2-2 | 4 | 8,019 | Doug Bird | Pat Zachry | Pat Zachry | Doug Bird | | 15 | 17 | -2 |
| 1982-04-11 | vs NYN | 5 | L 4-5 | 2-3 | 4 | 5,430 | Dan Larson | Pete Falcone | Pete Falcone | Dan Larson | Neil Allen | 19 | 22 | -3 |
| 1982-04-12 | vs NYN | 6 | W 5-4 | 3-3 | 3 | 6,866 | Dickie Noles | Craig Swan | Dickie Noles | Craig Swan | Bill Campbell | 24 | 26 | -2 |
| 1982-04-13 | vs SLN | 7 | L 3-4 | 3-4 | 4 | 6,472 | Randy Martz | Joaquin Andujar | Joaquin Andujar | Randy Martz | Bruce Sutter | 27 | 30 | -3 |
| 1982-04-14 | vs SLN | 8 | L 1-3 | 3-5 | 4 | 11,655 | Fergie Jenkins | Andy Rincon | Andy Rincon | Fergie Jenkins | | 28 | 33 | -5 |
| 1982-04-15 | vs SLN | 9 | L 1-6 | 3-6 | 5 | 13,673 | Doug Bird | Steve Mura | Steve Mura | Doug Bird | | 29 | 39 | -10 |
| 1982-04-16 | @ PIT | 10 | L 6-7 | 3-7 | 5 | 28,985 | Dan Larson | John Candelaria | Enrique Romo | Guillermo Hernandez | | 35 | 46 | -11 |
| 1982-04-17 | @ PIT | 11 | W 10-2 | 4-7 | 5 | 6,436 | Dickie Noles | Ross Baumgarten | Dickie Noles | Ross Baumgarten | | 45 | 48 | -3 |
| 1982-04-18 | @ PIT | 12 | W 5-1 | 5-7 | 4 | 8,028 | Fergie Jenkins | Eddie Solomon | Fergie Jenkins | Eddie Solomon | Randy Martz | 50 | 49 | 1 |
| 1982-04-20 | @ NYN | 13 | L 2-3 | 5-8 | 4 | 8,226 | Doug Bird | Mike Scott | Mike Scott | Doug Bird | Neil Allen | 52 | 52 | 0 |
| 1982-04-21 | @ NYN | 14 | L 4-7 | 5-9 | 4 | 8,815 | Dan Larson | Pat Zachry | Craig Swan | Bill Campbell | Neil Allen | 56 | 59 | -3 |
| 1982-04-23 | vs PIT | 15 | L 10-12 | 5-10 | 5 | 8,813 | Dickie Noles | Eddie Solomon | Eddie Solomon | Dickie Noles | Kent Tekulve | 66 | 71 | -5 |
| 1982-04-24 | vs PIT | 16 | L 5-8 | 5-11 | 5 | 19,312 | Fergie Jenkins | Ross Baumgarten | Don Robinson | Randy Martz | | 71 | 79 | -8 |
| 1982-04-25 | vs PIT | 17 | W 5-3 | 6-11 | 5 | 29,832 | Doug Bird | Rick Rhoden | Randy Martz | Rick Rhoden | | 76 | 82 | -6 |
| 1982-04-27 | vs CIN | 18 | L 3-6 | 6-12 | 5 | 3,743 | Dan Larson | Bruce Berenyi | Bruce Berenyi | Dan Larson | Jim Kern | 79 | 88 | -9 |
| 1982-04-28 | vs CIN | 19 | W 6-0 | 7-12 | 5 | 5,335 | Dickie Noles | Tom Seaver | Dickie Noles | Tom Seaver | | 85 | 88 | -3 |
| 1982-04-29 | @ ATL | 20 | L 0-3 | 7-13 | 5 | 8,802 | Fergie Jenkins | Joe Cowley | Gene Garber | Fergie Jenkins | Rick Camp | 85 | 91 | -6 |
| 1982-04-30 | @ ATL | 21 | L 0-1 | 7-14 | 5 | 19,757 | Doug Bird | Steve Bedrosian | Steve Bedrosian | Doug Bird | Gene Garber | 85 | 92 | -7 |
| 1982-05-01 | @ ATL | 22 | W 5-1 | 8-14 | 5 | 27,094 | Randy Martz | Rick Mahler | Randy Martz | Rick Mahler | | 90 | 93 | -3 |
| 1982-05-02 | @ ATL | 23 | L 3-10 | 8-15 | 5 | 19,494 | Dan Larson | Bob Walk | Bob Walk | Dan Larson | | 93 | 103 | -10 |
| 1982-05-03 | @ SLN | 24 | L 4-9 | 8-16 | 6 | 14,521 | Dickie Noles | Bob Forsch | Doug Bair | Dickie Noles | | 97 | 112 | -15 |
| 1982-05-04 | @ SLN | 25 | L 4-7 | 8-17 | 6 | 22,123 | Fergie Jenkins | Joaquin Andujar | Joaquin Andujar | Fergie Jenkins | Bruce Sutter | 101 | 119 | -18 |
| 1982-05-05 | @ SLN | 26 | L 6-7 | 8-18 | 6 | 22,528 | Doug Bird | Andy Rincon | Doug Bair | Guillermo Hernandez | Bruce Sutter | 107 | 126 | -19 |
| 1982-05-07 | vs HOU | 27 | W 12-6 | 9-18 | 6 | 6,404 | Randy Martz | Nolan Ryan | Randy Martz | Nolan Ryan | | 119 | 132 | -13 |
| 1982-05-08 | vs HOU | 28 | W 3-2 | 10-18 | 6 | 22,151 | Dickie Noles | Joe Niekro | Dickie Noles | Joe Niekro | Bill Campbell | 122 | 134 | -12 |
| 1982-05-09 | vs HOU | 29 | W 6-3 | 11-18 | 6 | 14,343 | Fergie Jenkins | Bob Knepper | Guillermo Hernandez | Randy Moffitt | | 128 | 137 | -9 |
| 1982-05-11 | vs ATL | 30 | W 6-4 | 12-18 | 6 | 11,876 | Doug Bird | Rick Mahler | Doug Bird | Rick Mahler | Guillermo Hernandez | 134 | 141 | -7 |
| 1982-05-12 | vs ATL | 31 | L 3-6 | 12-19 | 6 | 11,392 | Randy Martz | Bob Walk | Bob Walk | Randy Martz | Gene Garber | 137 | 147 | -10 |
| 1982-05-13 | @ HOU | 32 | W 5-0 | 13-19 | 6 | 13,534 | Allen Ripley | Joe Niekro | Allen Ripley | Joe Niekro | Lee Smith | 142 | 147 | -5 |
| 1982-05-14 | @ HOU | 33 | W 6-3 | 14-19 | 6 | 19,193 | Dickie Noles | Bob Knepper | Dickie Noles | Bob Knepper | Guillermo Hernandez | 148 | 150 | -2 |
| 1982-05-15 | @ HOU | 34 | L 1-4 | 14-20 | 6 | 43,543 | Fergie Jenkins | Don Sutton | Don Sutton | Fergie Jenkins | | 149 | 154 | -5 |
| 1982-05-16 | @ HOU | 35 | W 2-1 | 15-20 | 6 | 21,267 | Doug Bird | Nolan Ryan | Doug Bird | Nolan Ryan | Guillermo Hernandez | 151 | 155 | -4 |
| 1982-05-18 | @ LAN | 36 | L 1-2 | 15-21 | 6 | 39,910 | Randy Martz | Bob Welch | Tom Niedenfuer | Bill Campbell | | 152 | 157 | -5 |
| 1982-05-19 | @ LAN | 37 | L 1-4 | 15-22 | 6 | 43,083 | Dickie Noles | Dave Stewart | Dave Stewart | Dickie Noles | Tom Niedenfuer | 153 | 161 | -8 |
| 1982-05-20 | @ LAN | 38 | W 8-3 | 16-22 | 6 | 50,904 | Fergie Jenkins | Fernando Valenzuela | Fergie Jenkins | Fernando Valenzuela | | 161 | 164 | -3 |
| 1982-05-21 | @ SFN | 39 | W 6-4 | 17-22 | 5 | 20,650 | Doug Bird | Renie Martin | Dick Tidrow | Renie Martin | Bill Campbell | 167 | 168 | -1 |
| 1982-05-22 | @ SFN | 40 | W 2-1 | 18-22 | 5 | 8,401 | Allen Ripley | Atlee Hammaker | Allen Ripley | Atlee Hammaker | Guillermo Hernandez | 169 | 169 | 0 |
| 1982-05-23 | @ SFN | 41 | L 3-4 | 18-24 | 5 | 0 | Randy Martz | Bill Laskey | Gary Lavelle | Dick Tidrow | | 172 | 173 | -1 |
| 1982-05-23 | @ SFN | 42 | L 3-6 | 18-24 | 5 | 17,865 | Dan Larson | Mike Chris | Dan Schatzeder | Dan Larson | Jim Barr | 175 | 179 | -4 |
| 1982-05-24 | @ SDN | 43 | L 2-8 | 18-25 | 6 | 8,635 | Dickie Noles | Tim Lollar | Tim Lollar | Dickie Noles | | 177 | 187 | -10 |
| 1982-05-25 | @ SDN | 44 | L 1-2 | 18-26 | 6 | 14,261 | Fergie Jenkins | Chris Welsh | Chris Welsh | Fergie Jenkins | Floyd Chiffer | 178 | 189 | -11 |
| 1982-05-26 | @ SDN | 45 | W 5-3 | 19-26 | 5 | 9,433 | Allen Ripley | John Montefusco | Guillermo Hernandez | Luis DeLeon | Bill Campbell | 183 | 192 | -9 |
| 1982-05-28 | vs LAN | 46 | W 4-3 | 20-26 | 5 | 14,644 | Randy Martz | Bob Welch | Randy Martz | Bob Welch | Bill Campbell | 187 | 195 | -8 |
| 1982-05-29 | vs LAN | 47 | W 3-2 | 21-26 | 5 | 25,671 | Dickie Noles | Dave Stewart | Lee Smith | Alejandro Pena | | 190 | 197 | -7 |
| 1982-05-30 | vs LAN | 48 | L 0-7 | 21-27 | 5 | 34,306 | Fergie Jenkins | Fernando Valenzuela | Fernando Valenzuela | Fergie Jenkins | | 190 | 204 | -14 |
| 1982-05-31 | vs SDN | 49 | L 7-9 | 21-28 | 5 | 20,093 | Doug Bird | Chris Welsh | Chris Welsh | Doug Bird | Luis DeLeon | 197 | 213 | -16 |
| 1982-06-01 | vs SDN | 50 | L 1-9 | 21-29 | 5 | 8,797 | Randy Martz | John Montefusco | John Montefusco | Randy Martz | Eric Show | 198 | 222 | -24 |
| 1982-06-02 | vs SDN | 51 | L 1-3 | 21-30 | 6 | 12,605 | Dickie Noles | Juan Eichelberger | Juan Eichelberger | Dickie Noles | | 199 | 225 | -26 |
| 1982-06-04 | vs SFN | 52 | L 3-4 | 21-31 | 6 | 7,034 | Fergie Jenkins | Mike Chris | Fred Breining | Fergie Jenkins | Greg Minton | 202 | 229 | -27 |
| 1982-06-05 | vs SFN | 53 | L 1-2 | 21-32 | 6 | 24,072 | Doug Bird | Rich Gale | Rich Gale | Doug Bird | Greg Minton | 203 | 231 | -28 |
| 1982-06-06 | vs SFN | 54 | L 3-5 | 21-33 | 6 | 14,730 | Randy Martz | Renie Martin | Renie Martin | Randy Martz | Greg Minton | 206 | 236 | -30 |
| 1982-06-07 | @ PHI | 55 | L 5-7 | 21-34 | 6 | 30,146 | Dickie Noles | Dick Ruthven | Sid Monge | Lee Smith | Ed Farmer | 211 | 243 | -32 |
| 1982-06-08 | @ PHI | 56 | L 2-5 | 21-35 | 6 | 30,289 | Tom Filer | Marty Bystrom | Marty Bystrom | Tom Filer | Sparky Lyle | 213 | 248 | -35 |
| 1982-06-09 | @ PHI | 57 | L 2-4 | 21-36 | 6 | 31,099 | Fergie Jenkins | Steve Carlton | Steve Carlton | Fergie Jenkins | | 215 | 252 | -37 |
| 1982-06-11 | @ MON | 58 | L 8-9 | 21-37 | 6 | 31,121 | Doug Bird | Charlie Lea | Woodie Fryman | Bill Campbell | Jeff Reardon | 223 | 261 | -38 |
| 1982-06-12 | @ MON | 59 | L 5-7 | 21-38 | 6 | 32,502 | Randy Martz | David Palmer | Ray Burris | Guillermo Hernandez | Jeff Reardon | 228 | 268 | -40 |
| 1982-06-13 | @ MON | 60 | L 3-5 | 21-39 | 6 | 35,428 | Tom Filer | Steve Rogers | Woodie Fryman | Guillermo Hernandez | | 231 | 273 | -42 |
| 1982-06-14 | vs PHI | 61 | W 12-11 | 22-39 | 6 | 10,797 | Fergie Jenkins | Steve Carlton | Fergie Jenkins | Steve Carlton | | 243 | 284 | -41 |
| 1982-06-15 | vs PHI | 62 | W 8-5 | 23-39 | 6 | 8,639 | Doug Bird | Dick Ruthven | Doug Bird | Dick Ruthven | Mike Proly | 251 | 289 | -38 |
| 1982-06-16 | vs PHI | 63 | W 7-6 | 24-39 | 6 | 9,377 | Lee Smith | Marty Bystrom | Dick Tidrow | Warren Brusstar | | 258 | 295 | -37 |
| 1982-06-17 | vs MON | 64 | W 12-8 | 25-39 | 6 | 9,290 | Randy Martz | David Palmer | Mike Proly | David Palmer | | 270 | 303 | -33 |
| 1982-06-18 | vs MON | 65 | L 0-4 | 25-40 | 6 | 6,659 | Tom Filer | Steve Rogers | Steve Rogers | Tom Filer | | 270 | 307 | -37 |
| 1982-06-19 | vs MON | 66 | L 2-5 | 25-41 | 6 | 23,352 | Fergie Jenkins | Bill Gullickson | Ray Burris | Guillermo Hernandez | Jeff Reardon | 272 | 312 | -40 |
| 1982-06-20 | vs MON | 67 | L 5-11 | 25-42 | 6 | 22,237 | Doug Bird | Scott Sanderson | Scott Sanderson | Doug Bird | | 277 | 323 | -46 |
| 1982-06-21 | @ PIT | 68 | L 3-4 | 25-43 | 6 | 6,136 | Lee Smith | Paul Moskau | Paul Moskau | Lee Smith | Kent Tekulve | 280 | 327 | -47 |
| 1982-06-22 | @ PIT | 69 | L 2-9 | 25-44 | 6 | 6,174 | Randy Martz | John Candelaria | John Candelaria | Randy Martz | Enrique Romo | 282 | 336 | -54 |
| 1982-06-23 | @ PIT | 70 | W 6-5 | 26-44 | 6 | 8,297 | Tom Filer | Manny Sarmiento | Bill Campbell | Randy Niemann | | 288 | 341 | -53 |
| 1982-06-25 | vs SLN | 71 | W 5-3 | 27-44 | 6 | 16,414 | Fergie Jenkins | Joaquin Andujar | Fergie Jenkins | Joaquin Andujar | | 293 | 344 | -51 |
| 1982-06-26 | vs SLN | 72 | L 1-4 | 27-46 | 6 | 0 | Doug Bird | Dave LaPoint | Dave LaPoint | Doug Bird | Bruce Sutter | 294 | 348 | -54 |
| 1982-06-26 | vs SLN | 73 | L 1-2 | 27-46 | 6 | 29,357 | Lee Smith | Jim Kaat | Jim Kaat | Lee Smith | Bruce Sutter | 295 | 350 | -55 |
| 1982-06-27 | vs SLN | 74 | W 4-2 | 28-46 | 6 | 24,674 | Allen Ripley | John Stuper | Allen Ripley | John Stuper | Bill Campbell | 299 | 352 | -53 |
| 1982-06-28 | vs PIT | 75 | W 6-4 | 29-46 | 6 | 6,974 | Tom Filer | Manny Sarmiento | Dick Tidrow | Enrique Romo | | 305 | 356 | -51 |
| 1982-06-29 | vs PIT | 76 | L 1-3 | 29-47 | 6 | 22,109 | Fergie Jenkins | Rick Rhoden | Rick Rhoden | Fergie Jenkins | | 306 | 359 | -53 |
| 1982-06-30 | vs PIT | 77 | L 3-7 | 29-48 | 6 | 10,058 | Lee Smith | Don Robinson | Don Robinson | Lee Smith | Rod Scurry | 309 | 366 | -57 |
| 1982-07-01 | vs PIT | 78 | L 2-5 | 29-49 | 6 | 10,463 | Doug Bird | Ross Baumgarten | Enrique Romo | Bill Campbell | | 311 | 371 | -60 |
| 1982-07-02 | @ SLN | 79 | W 4-3 | 30-49 | 6 | 27,318 | Allen Ripley | Dave LaPoint | Ken Kravec | Dave LaPoint | Dick Tidrow | 315 | 374 | -59 |
| 1982-07-03 | @ SLN | 80 | W 2-1 | 31-49 | 6 | 32,156 | Tom Filer | Joaquin Andujar | Tom Filer | Joaquin Andujar | Guillermo Hernandez | 317 | 375 | -58 |
| 1982-07-04 | @ SLN | 81 | L 2-7 | 31-50 | 6 | 26,126 | Dickie Noles | John Stuper | John Stuper | Dickie Noles | Bruce Sutter | 319 | 382 | -63 |
| 1982-07-05 | @ ATL | 82 | L 5-7 | 31-51 | 6 | 19,169 | Lee Smith | Phil Niekro | Al Hrabosky | Lee Smith | Gene Garber | 324 | 389 | -65 |
| 1982-07-06 | @ ATL | 83 | W 7-2 | 32-51 | 6 | 15,108 | Doug Bird | Ken Dayley | Doug Bird | Ken Dayley | Guillermo Hernandez | 331 | 391 | -60 |
| 1982-07-07 | @ HOU | 84 | L 1-5 | 32-52 | 6 | 17,105 | Allen Ripley | Don Sutton | Don Sutton | Allen Ripley | | 332 | 396 | -64 |
| 1982-07-08 | @ HOU | 85 | W 5-3 | 33-52 | 6 | 11,023 | Tom Filer | Vern Ruhle | Dick Tidrow | Vern Ruhle | Guillermo Hernandez | 337 | 399 | -62 |
| 1982-07-09 | vs CIN | 86 | W 12-0 | 34-52 | 6 | 14,891 | Fergie Jenkins | Bob Shirley | Fergie Jenkins | Bob Shirley | | 349 | 399 | -50 |
| 1982-07-10 | vs CIN | 87 | W 1-0 | 35-53 | 6 | 0 | Dickie Noles | Bruce Berenyi | Dickie Noles | Bruce Berenyi | | 350 | 399 | -49 |
| 1982-07-10 | vs CIN | 88 | L 5-6 | 35-53 | 6 | 20,294 | Ken Kravec | Charlie Leibrandt | Mario Soto | Mike Proly | | 355 | 405 | -50 |
| 1982-07-11 | vs CIN | 89 | W 9-2 | 36-53 | 6 | 20,307 | Doug Bird | Tom Seaver | Doug Bird | Tom Seaver | | 364 | 407 | -43 |
| 1982-07-15 | vs ATL | 90 | L 4-11 | 36-54 | 6 | 19,336 | Fergie Jenkins | Phil Niekro | Phil Niekro | Fergie Jenkins | | 368 | 418 | -50 |
| 1982-07-16 | vs ATL | 91 | W 4-3 | 37-54 | 6 | 15,624 | Allen Ripley | Rick Mahler | Bill Campbell | Gene Garber | | 372 | 421 | -49 |
| 1982-07-17 | vs ATL | 92 | L 4-9 | 37-55 | 6 | 23,302 | Dickie Noles | Bob Walk | Bob Walk | Dickie Noles | | 376 | 430 | -54 |
| 1982-07-18 | vs ATL | 93 | L 2-4 | 37-56 | 6 | 15,816 | Doug Bird | Rick Camp | Rick Camp | Doug Bird | | 378 | 434 | -56 |
| 1982-07-19 | vs HOU | 94 | W 6-5 | 38-56 | 6 | 13,538 | Tom Filer | Vern Ruhle | Lee Smith | Frank LaCorte | | 384 | 439 | -55 |
| 1982-07-20 | vs HOU | 95 | W 5-3 | 39-56 | 6 | 16,284 | Fergie Jenkins | Don Sutton | Guillermo Hernandez | Don Sutton | Dick Tidrow | 389 | 442 | -53 |
| 1982-07-21 | vs HOU | 96 | L 1-2 | 39-57 | 6 | 13,264 | Allen Ripley | Nolan Ryan | Nolan Ryan | Allen Ripley | Frank LaCorte | 390 | 444 | -54 |
| 1982-07-23 | @ CIN | 97 | W 7-5 | 40-57 | 6 | 17,939 | Dickie Noles | Mario Soto | Guillermo Hernandez | Jim Kern | Lee Smith | 397 | 449 | -52 |
| 1982-07-24 | @ CIN | 98 | L 2-5 | 40-58 | 6 | 28,138 | Doug Bird | Frank Pastore | Frank Pastore | Doug Bird | Joe Price | 399 | 454 | -55 |
| 1982-07-25 | @ CIN | 99 | L 1-2 | 40-59 | 6 | 20,056 | Fergie Jenkins | Bruce Berenyi | Bruce Berenyi | Fergie Jenkins | | 400 | 456 | -56 |
| 1982-07-26 | @ CIN | 100 | L 2-4 | 40-60 | 6 | 13,092 | Allen Ripley | Bob Shirley | Bob Shirley | Allen Ripley | Tom Hume | 402 | 460 | -58 |
| 1982-07-27 | vs MON | 101 | L 3-4 | 40-61 | 6 | 13,771 | Randy Martz | Steve Rogers | Steve Rogers | Randy Martz | | 405 | 464 | -59 |
| 1982-07-28 | vs MON | 102 | L 3-5 | 40-62 | 6 | 20,831 | Dickie Noles | Bill Gullickson | Bill Gullickson | Dickie Noles | | 408 | 469 | -61 |
| 1982-07-29 | @ PHI | 103 | L 2-3 | 40-63 | 6 | 33,724 | Doug Bird | Mike Krukow | Mike Krukow | Dick Tidrow | Ron Reed | 410 | 472 | -62 |
| 1982-07-30 | @ PHI | 104 | L 1-3 | 40-64 | 6 | 33,165 | Fergie Jenkins | Steve Carlton | Steve Carlton | Fergie Jenkins | | 411 | 475 | -64 |
| 1982-07-31 | @ PHI | 105 | L 0-2 | 40-65 | 6 | 50,203 | Allen Ripley | Marty Bystrom | Marty Bystrom | Allen Ripley | Porfi Altamirano | 411 | 477 | -66 |
| 1982-08-01 | @ PHI | 106 | W 7-2 | 41-65 | 6 | 57,652 | Dickie Noles | Dick Ruthven | Dickie Noles | Dick Ruthven | | 418 | 479 | -61 |
| 1982-08-03 | vs NYN | 107 | W 5-0 | 42-65 | 6 | 13,070 | Doug Bird | Brent Gaff | Doug Bird | Brent Gaff | | 423 | 479 | -56 |
| 1982-08-04 | vs NYN | 108 | L 4-7 | 42-66 | 6 | 9,237 | Fergie Jenkins | Craig Swan | Craig Swan | Fergie Jenkins | Pete Falcone | 427 | 486 | -59 |
| 1982-08-05 | vs NYN | 109 | W 5-1 | 43-66 | 6 | 15,658 | Randy Martz | Charlie Puleo | Randy Martz | Charlie Puleo | | 432 | 487 | -55 |
| 1982-08-06 | vs PHI | 110 | W 4-2 | 44-66 | 6 | 17,163 | Allen Ripley | Dick Ruthven | Allen Ripley | Dick Ruthven | Lee Smith | 436 | 489 | -53 |
| 1982-08-07 | vs PHI | 111 | W 3-2 | 45-66 | 6 | 25,871 | Dickie Noles | Larry Christenson | Dickie Noles | Larry Christenson | Lee Smith | 439 | 491 | -52 |
| 1982-08-08 | vs PHI | 112 | W 8-5 | 46-66 | 6 | 28,279 | Doug Bird | Mike Krukow | Dick Tidrow | Tug McGraw | Lee Smith | 447 | 496 | -49 |
| 1982-08-09 | @ MON | 113 | W 9-2 | 47-66 | 6 | 29,276 | Fergie Jenkins | Scott Sanderson | Fergie Jenkins | Scott Sanderson | | 456 | 498 | -42 |
| 1982-08-10 | @ MON | 114 | W 5-3 | 48-66 | 6 | 30,918 | Randy Martz | Steve Rogers | Randy Martz | Steve Rogers | Dick Tidrow | 461 | 501 | -40 |
| 1982-08-11 | @ MON | 115 | L 0-3 | 48-67 | 6 | 25,140 | Allen Ripley | Charlie Lea | Charlie Lea | Allen Ripley | Jeff Reardon | 461 | 504 | -43 |
| 1982-08-12 | @ NYN | 116 | W 13-6 | 49-67 | 6 | 11,942 | Dickie Noles | Mike Scott | Mike Proly | Jesse Orosco | Dick Tidrow | 474 | 510 | -36 |
| 1982-08-13 | @ NYN | 117 | L 4-6 | 49-68 | 6 | 12,617 | Doug Bird | Pat Zachry | Jesse Orosco | Mike Proly | | 478 | 516 | -38 |
| 1982-08-14 | @ NYN | 118 | W 7-4 | 50-68 | 6 | 21,906 | Fergie Jenkins | Craig Swan | Mike Proly | Pete Falcone | Lee Smith | 485 | 520 | -35 |
| 1982-08-15 | @ NYN | 119 | L 4-5 | 51-69 | 6 | 0 | Randy Martz | Ed Lynch | Ed Lynch | Randy Martz | Pat Zachry | 489 | 525 | -36 |
| 1982-08-15 | @ NYN | 120 | W 6-5 | 51-69 | 6 | 23,545 | Ken Kravec | Charlie Puleo | Mike Proly | Jesse Orosco | Lee Smith | 495 | 530 | -35 |
| 1982-08-17 | vs LAN | 121 | L 1-2 | 51-70 | 6 | 26,576 | Dickie Noles | Burt Hooton | Jerry Reuss | Allen Ripley | | 496 | 532 | -36 |
| 1982-08-18 | vs LAN | 122 | L 4-7 | 51-71 | 6 | 27,429 | Doug Bird | Jerry Reuss | Jerry Reuss | Doug Bird | Tom Niedenfuer | 500 | 539 | -39 |
| 1982-08-19 | vs LAN | 123 | W 8-2 | 52-71 | 5 | 19,461 | Fergie Jenkins | Bob Welch | Fergie Jenkins | Bob Welch | | 508 | 541 | -33 |
| 1982-08-20 | vs SDN | 124 | W 3-2 | 53-71 | 5 | 18,110 | Randy Martz | John Montefusco | Randy Martz | John Montefusco | Guillermo Hernandez | 511 | 543 | -32 |
| 1982-08-21 | vs SDN | 125 | L 0-2 | 53-72 | 5 | 32,365 | Allen Ripley | Tim Lollar | Tim Lollar | Allen Ripley | Luis DeLeon | 511 | 545 | -34 |
| 1982-08-22 | vs SDN | 126 | W 8-7 | 54-72 | 5 | 23,601 | Dickie Noles | Eric Show | Dick Tidrow | Gary Lucas | Lee Smith | 519 | 552 | -33 |
| 1982-08-23 | vs SFN | 127 | W 8-5 | 55-72 | 5 | 13,780 | Doug Bird | Renie Martin | Doug Bird | Renie Martin | Dick Tidrow | 527 | 557 | -30 |
| 1982-08-24 | vs SFN | 128 | W 8-4 | 56-72 | 5 | 13,712 | Fergie Jenkins | Rich Gale | Fergie Jenkins | Rich Gale | | 535 | 561 | -26 |
| 1982-08-25 | vs SFN | 129 | W 4-2 | 57-72 | 5 | 17,291 | Randy Martz | Jim Barr | Randy Martz | Jim Barr | Lee Smith | 539 | 563 | -24 |
| 1982-08-27 | @ LAN | 130 | L 4-9 | 57-73 | 5 | 51,635 | Allen Ripley | Burt Hooton | Ricky Wright | Mike Proly | Tom Niedenfuer | 543 | 572 | -29 |
| 1982-08-28 | @ LAN | 131 | L 1-7 | 57-74 | 5 | 50,528 | Dickie Noles | Jerry Reuss | Jerry Reuss | Dickie Noles | | 544 | 579 | -35 |
| 1982-08-29 | @ LAN | 132 | W 7-2 | 58-74 | 5 | 47,943 | Fergie Jenkins | Bob Welch | Fergie Jenkins | Bob Welch | | 551 | 581 | -30 |
| 1982-08-31 | @ SFN | 133 | L 3-4 | 58-75 | 5 | 8,827 | Randy Martz | Fred Breining | Al Holland | Guillermo Hernandez | Greg Minton | 554 | 585 | -31 |
| 1982-09-01 | @ SFN | 134 | W 7-6 | 59-75 | 5 | 7,463 | Allen Ripley | Bill Laskey | Bill Campbell | Rich Gale | Lee Smith | 561 | 591 | -30 |
| 1982-09-03 | @ SDN | 135 | L 0-3 | 59-76 | 5 | 9,458 | Dickie Noles | Eric Show | Eric Show | Dickie Noles | | 561 | 594 | -33 |
| 1982-09-04 | @ SDN | 136 | L 1-4 | 59-77 | 5 | 13,440 | Fergie Jenkins | Tim Lollar | Tim Lollar | Fergie Jenkins | | 562 | 598 | -36 |
| 1982-09-05 | @ SDN | 137 | W 5-1 | 60-77 | 5 | 36,693 | Randy Martz | Dave Dravecky | Randy Martz | Dave Dravecky | | 567 | 599 | -32 |
| 1982-09-06 | vs PHI | 138 | W 4-3 | 61-77 | 5 | 23,510 | Doug Bird | Mike Krukow | Doug Bird | Mike Krukow | Lee Smith | 571 | 602 | -31 |
| 1982-09-07 | vs PHI | 139 | L 5-7 | 61-78 | 5 | 7,003 | Allen Ripley | Larry Christenson | Tug McGraw | Bill Campbell | | 576 | 609 | -33 |
| 1982-09-08 | vs PHI | 140 | L 3-4 | 61-79 | 5 | 8,233 | Dickie Noles | Steve Carlton | Steve Carlton | Dick Tidrow | Ron Reed | 579 | 613 | -34 |
| 1982-09-10 | vs MON | 141 | L 2-7 | 61-80 | 5 | 8,100 | Fergie Jenkins | Steve Rogers | Steve Rogers | Fergie Jenkins | Jeff Reardon | 581 | 620 | -39 |
| 1982-09-11 | vs MON | 142 | L 6-10 | 61-81 | 5 | 25,550 | Randy Martz | Scott Sanderson | Scott Sanderson | Randy Martz | Woodie Fryman | 587 | 630 | -43 |
| 1982-09-12 | vs MON | 143 | L 3-11 | 61-82 | 5 | 13,029 | Doug Bird | Bill Gullickson | Bill Gullickson | Doug Bird | | 590 | 641 | -51 |
| 1982-09-13 | @ PIT | 144 | W 7-3 | 62-82 | 5 | 2,859 | Allen Ripley | Don Robinson | Allen Ripley | Don Robinson | Guillermo Hernandez | 597 | 644 | -47 |
| 1982-09-14 | @ PIT | 145 | L 5-15 | 62-83 | 5 | 4,822 | Dickie Noles | Lee Tunnell | Randy Niemann | Dickie Noles | Larry McWilliams | 602 | 659 | -57 |
| 1982-09-15 | @ PIT | 146 | W 7-2 | 63-83 | 5 | 8,678 | Fergie Jenkins | John Candelaria | Fergie Jenkins | John Candelaria | | 609 | 661 | -52 |
| 1982-09-17 | @ MON | 147 | W 3-1 | 64-83 | 5 | 24,709 | Randy Martz | Bill Gullickson | Randy Martz | Bill Gullickson | Lee Smith | 612 | 662 | -50 |
| 1982-09-18 | @ MON | 148 | W 10-7 | 65-83 | 5 | 25,171 | Doug Bird | Randy Lerch | Dick Tidrow | Woodie Fryman | Lee Smith | 622 | 669 | -47 |
| 1982-09-19 | @ MON | 149 | W 7-5 | 66-83 | 5 | 42,491 | Allen Ripley | Steve Rogers | Dick Tidrow | Bryn Smith | Lee Smith | 629 | 674 | -45 |
| 1982-09-20 | vs PIT | 150 | W 3-1 | 67-83 | 5 | 3,607 | Dickie Noles | Larry McWilliams | Dickie Noles | Larry McWilliams | Dick Tidrow | 632 | 675 | -43 |
| 1982-09-21 | vs PIT | 151 | W 1-0 | 68-83 | 5 | 5,237 | Fergie Jenkins | Lee Tunnell | Fergie Jenkins | Rod Scurry | Bill Campbell | 633 | 675 | -42 |
| 1982-09-22 | vs NYN | 152 | L 2-5 | 68-84 | 5 | 3,142 | Randy Martz | Scott Holman | Scott Holman | Randy Martz | Doug Sisk | 635 | 680 | -45 |
| 1982-09-23 | vs NYN | 153 | L 4-5 | 68-85 | 5 | 4,344 | Doug Bird | Ed Lynch | Ed Lynch | Doug Bird | Jesse Orosco | 639 | 685 | -46 |
| 1982-09-24 | @ SLN | 154 | L 1-3 | 68-86 | 5 | 30,862 | Allen Ripley | John Stuper | John Stuper | Bill Campbell | | 640 | 688 | -48 |
| 1982-09-25 | @ SLN | 155 | L 1-5 | 68-87 | 5 | 37,565 | Dickie Noles | Joaquin Andujar | Joaquin Andujar | Dickie Noles | | 641 | 693 | -52 |
| 1982-09-26 | @ SLN | 156 | W 6-1 | 69-87 | 5 | 46,789 | Fergie Jenkins | Eric Rasmussen | Fergie Jenkins | Eric Rasmussen | | 647 | 694 | -47 |
| 1982-09-27 | @ PHI | 157 | W 8-1 | 70-87 | 5 | 15,744 | Randy Martz | Marty Bystrom | Randy Martz | Marty Bystrom | | 655 | 695 | -40 |
| 1982-09-28 | @ PHI | 158 | L 2-3 | 70-88 | 5 | 14,431 | Doug Bird | Larry Christenson | Larry Christenson | Doug Bird | Ron Reed | 657 | 698 | -41 |
| 1982-09-29 | @ NYN | 159 | W 4-1 | 71-88 | 5 | 3,175 | Mike Proly | Walt Terrell | Mike Proly | Walt Terrell | Lee Smith | 661 | 699 | -38 |
| 1982-09-30 | @ NYN | 160 | W 3-1 | 72-88 | 5 | 5,293 | Dickie Noles | Tom Gorman | Dickie Noles | Tom Gorman | Lee Smith | 664 | 700 | -36 |
| 1982-10-02 | vs SLN | 161 | W 8-4 | 73-88 | 5 | 34,003 | Fergie Jenkins | Joaquin Andujar | Fergie Jenkins | Jim Kaat | Bill Campbell | 672 | 704 | -32 |
| 1982-10-03 | vs SLN | 162 | L 4-5 | 73-89 | 5 | 21,411 | Doug Bird | Dave LaPoint | Eric Rasmussen | Ken Kravec | | 676 | 709 | -33 |