| West | W | L | Pct | GB |
| KC Royals | 97 | 65 | .599 | -- |
| Oakland | 83 | 79 | .512 | 14.0 |
| Minnesota | 77 | 84 | .478 | 19.5 |
| Texas | 76 | 85 | .472 | 20.5 |
| Chi White Sox | 70 | 90 | .437 | 26.0 |
| California | 65 | 95 | .406 | 31.0 |
| Seattle | 59 | 103 | .364 | 38.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 1980-04-10 | Jon Matlack | L | 30 | L 1-0 | vs NYA | 1 | 246 | - | 9.0 | 3 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | -- | 0-0 | 0.00 | 0.33 |
| 1980-04-11 | Fergie Jenkins | R | 36 | L 11-7 | vs NYA | 1 | 487 | W | 5.0 | 4 | 6 | 6 | 2 | 5 | 4 | 0 | 0 | 0 | -- | 1-0 | 10.80 | 1.80 |
| 1980-04-13 | Steve Comer | R | 26 | W 4-9 | vs NYA | 1 | 48 | L | 5.0 | 7 | 6 | 6 | 1 | 6 | 1 | 0 | 0 | 0 | -- | 0-1 | 10.80 | 2.60 |
| 1980-04-13 | Gaylord Perry | R | 42 | W 2-8 | vs NYA | 1 | 574 | L | 4.2 | 7 | 4 | 1 | 0 | 1 | 4 | 0 | 0 | 0 | -- | 0-1 | 1.80 | 1.60 |
| 1980-04-14 | Doc Medich | R | 31 | L 7-4 | vs CLE | 1 | 205 | W | 6.2 | 6 | 4 | 4 | 1 | 4 | 1 | 0 | 0 | 0 | -- | 1-0 | 5.14 | 1.43 |
| 1980-04-15 | Jon Matlack | L | 30 | L 3-0 | vs CLE | 2 | 247 | W | 9.0 | 5 | 0 | 0 | 0 | 1 | 4 | 0 | 0 | 0 | -- | 1-0 | 0.00 | 0.50 |
| 1980-04-16 | Fergie Jenkins | R | 36 | L 8-7 | vs CLE | 2 | 488 | - | 2.0 | 5 | 6 | 6 | 0 | 4 | 2 | 0 | 0 | 0 | -- | 1-0 | 15.43 | 2.57 |
| 1980-04-18 | Steve Comer | R | 26 | W 6-5 | @ BOS | 2 | 49 | - | 3.0 | 6 | 4 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | -- | 0-1 | 10.13 | 2.50 |
| 1980-04-19 | Gaylord Perry | R | 42 | W 8-0 | @ BOS | 2 | 575 | W | 9.0 | 5 | 0 | 0 | 0 | 2 | 3 | 0 | 0 | 0 | -- | 1-1 | 0.64 | 1.07 |
| 1980-04-20 | Doc Medich | R | 31 | L 5-6 | @ BOS | 2 | 206 | - | 2.1 | 5 | 4 | 4 | 0 | 1 | 1 | 0 | 0 | 0 | -- | 1-0 | 8.00 | 1.78 |
| 1980-04-21 | Jon Matlack | L | 30 | L 3-2 | vs DET | 3 | 248 | W | 8.1 | 6 | 2 | 2 | 0 | 2 | 8 | 0 | 0 | 0 | -- | 2-0 | 0.69 | 0.65 |
| 1980-04-22 | Fergie Jenkins | R | 36 | W 0-2 | vs DET | 3 | 489 | L | 9.0 | 8 | 2 | 2 | 1 | 3 | 3 | 0 | 0 | 0 | -- | 1-1 | 7.88 | 1.81 |
| 1980-04-23 | Steve Comer | R | 26 | W 4-5 | vs DET | 3 | 50 | L | 4.2 | 7 | 5 | 4 | 0 | 2 | 3 | 0 | 0 | 0 | -- | 0-2 | 9.00 | 2.23 |
| 1980-04-25 | Gaylord Perry | R | 42 | W 4-1 | @ CLE | 3 | 576 | - | 6.0 | 8 | 1 | 1 | 0 | 3 | 3 | 0 | 0 | 0 | -- | 1-1 | 0.90 | 1.30 |
| 1980-04-26 | Jon Matlack | L | 30 | L 7-8 | @ CLE | 4 | 249 | - | 5.0 | 6 | 4 | 3 | 0 | 2 | 6 | 0 | 0 | 0 | -- | 2-0 | 1.45 | 0.81 |
| 1980-04-27 | Fergie Jenkins | R | 36 | L 4-7 | @ CLE | 4 | 490 | L | 3.2 | 5 | 4 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | -- | 1-2 | 6.75 | 1.75 |
| 1980-04-29 | Steve Comer | R | 26 | W 10-5 | @ DET | 4 | 51 | W | 5.1 | 9 | 5 | 5 | 1 | 1 | 1 | 0 | 0 | 0 | -- | 1-2 | 9.00 | 2.17 |
| 1980-04-30 | Gaylord Perry | R | 42 | L 4-5 | @ DET | 4 | 577 | - | 6.0 | 6 | 4 | 4 | 2 | 2 | 2 | 0 | 0 | 0 | -- | 1-1 | 2.08 | 1.31 |
| 1980-05-02 | Jon Matlack | L | 30 | W 5-7 | vs BAL | 5 | 250 | - | 7.0 | 8 | 4 | 4 | 0 | 2 | 4 | 0 | 0 | 0 | -- | 2-0 | 2.13 | 0.92 |
| 1980-05-03 | Fergie Jenkins | R | 36 | L 3-2 | vs BAL | 5 | 491 | W | 9.0 | 8 | 2 | 2 | 1 | 0 | 8 | 0 | 0 | 0 | -- | 2-2 | 5.28 | 1.48 |
| 1980-05-04 | Steve Comer | R | 26 | W 5-9 | vs BAL | 5 | 52 | L | 0.1 | 3 | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | -- | 1-3 | 10.00 | 2.33 |
| 1980-05-05 | Gaylord Perry | R | 42 | L 11-3 | vs BOS | 5 | 578 | W | 9.0 | 8 | 3 | 3 | 1 | 1 | 5 | 0 | 0 | 0 | -- | 2-1 | 2.31 | 1.23 |
| 1980-05-06 | Doc Medich | R | 31 | L 7-2 | vs BOS | 3 | 207 | W | 9.0 | 6 | 2 | 2 | 1 | 1 | 7 | 0 | 0 | 0 | -- | 2-0 | 4.74 | 1.21 |
| 1980-05-07 | Jon Matlack | L | 30 | W 4-7 | vs BOS | 6 | 251 | - | 7.2 | 10 | 4 | 4 | 2 | 0 | 1 | 0 | 0 | 0 | -- | 2-0 | 2.54 | 0.98 |
| 1980-05-09 | Fergie Jenkins | R | 36 | L 2-1 | vs CHA | 6 | 492 | - | 10.1 | 6 | 1 | 1 | 1 | 1 | 5 | 0 | 0 | 0 | -- | 2-2 | 4.15 | 1.28 |
| 1980-05-10 | Gaylord Perry | R | 42 | W 6-10 | vs CHA | 6 | 579 | - | 2.2 | 4 | 5 | 5 | 0 | 3 | 4 | 0 | 0 | 0 | -- | 2-1 | 3.41 | 1.35 |
| 1980-05-11 | Doc Medich | R | 31 | L 5-1 | vs CHA | 4 | 208 | W | 7.1 | 6 | 1 | 1 | 0 | 1 | 4 | 0 | 0 | 0 | -- | 3-0 | 3.81 | 1.15 |
| 1980-05-12 | Jon Matlack | L | 30 | W 5-1 | @ BAL | 7 | 252 | W | 9.0 | 9 | 1 | 1 | 0 | 1 | 4 | 0 | 0 | 0 | -- | 3-0 | 2.29 | 1.00 |
| 1980-05-13 | Fergie Jenkins | R | 36 | L 2-4 | @ BAL | 7 | 493 | L | 7.1 | 7 | 3 | 3 | 1 | 1 | 3 | 0 | 0 | 0 | -- | 2-3 | 4.11 | 1.26 |
| 1980-05-14 | Gaylord Perry | R | 42 | W 6-3 | @ BAL | 7 | 580 | W | 7.2 | 10 | 3 | 2 | 0 | 4 | 4 | 0 | 0 | 0 | -- | 3-1 | 3.20 | 1.42 |
| 1980-05-16 | Doc Medich | R | 31 | L 2-6 | @ NYA | 5 | 209 | L | 3.1 | 7 | 4 | 4 | 1 | 2 | 3 | 0 | 0 | 0 | -- | 3-1 | 4.50 | 1.30 |
| 1980-05-17 | Jon Matlack | L | 30 | L 0-3 | @ NYA | 8 | 253 | L | 8.0 | 8 | 3 | 2 | 0 | 1 | 4 | 0 | 0 | 0 | -- | 3-1 | 2.29 | 1.02 |
| 1980-05-18 | Fergie Jenkins | R | 36 | W 5-4 | @ NYA | 8 | 494 | - | 4.2 | 6 | 4 | 3 | 1 | 1 | 2 | 0 | 0 | 0 | -- | 2-3 | 4.24 | 1.27 |
| 1980-05-19 | Gaylord Perry | R | 42 | W 2-3 | vs CAL | 8 | 581 | - | 7.0 | 6 | 2 | 2 | 1 | 1 | 8 | 0 | 0 | 0 | -- | 3-1 | 3.12 | 1.37 |
| 1980-05-20 | Doc Medich | R | 31 | W 4-5 | vs CAL | 6 | 210 | L | 5.1 | 8 | 5 | 4 | 1 | 1 | 3 | 0 | 0 | 0 | -- | 3-2 | 4.89 | 1.37 |
| 1980-05-21 | Steve Comer | R | 26 | W 8-9 | vs CAL | 6 | 53 | - | 4.0 | 6 | 4 | 4 | 2 | 2 | 2 | 0 | 0 | 0 | -- | 1-3 | 9.82 | 2.27 |
| 1980-05-22 | Jon Matlack | L | 30 | L 12-6 | vs CAL | 9 | 254 | - | 2.2 | 6 | 6 | 6 | 0 | 3 | 5 | 0 | 0 | 0 | -- | 3-1 | 3.00 | 1.11 |
| 1980-05-23 | Fergie Jenkins | R | 36 | W 3-1 | @ OAK | 9 | 495 | W | 9.0 | 2 | 1 | 0 | 0 | 3 | 8 | 0 | 0 | 0 | -- | 3-3 | 3.60 | 1.17 |
| 1980-05-24 | Gaylord Perry | R | 42 | L 7-15 | @ OAK | 9 | 582 | L | 3.1 | 6 | 6 | 4 | 0 | 4 | 2 | 0 | 0 | 0 | -- | 3-2 | 3.60 | 1.47 |
| 1980-05-25 | Doc Medich | R | 31 | W 7-3 | @ OAK | 7 | 211 | W | 6.1 | 7 | 3 | 3 | 1 | 3 | 6 | 0 | 0 | 0 | -- | 4-2 | 4.83 | 1.41 |
| 1980-05-26 | Danny Darwin | R | 25 | W 6-5 | @ CAL | 1 | 8 | - | 6.1 | 6 | 3 | 2 | 0 | 2 | 6 | 0 | 0 | 0 | -- | 3-1 | 2.12 | 1.38 |
| 1980-05-27 | Fergie Jenkins | R | 36 | L 0-2 | @ CAL | 10 | 496 | L | 5.0 | 4 | 1 | 1 | 0 | 2 | 1 | 0 | 0 | 0 | -- | 3-4 | 3.46 | 1.17 |
| 1980-05-28 | Jon Matlack | L | 30 | L 6-7 | @ CAL | 10 | 255 | - | 6.2 | 9 | 3 | 3 | 1 | 1 | 7 | 0 | 0 | 0 | -- | 3-1 | 3.13 | 1.15 |
| 1980-05-30 | Gaylord Perry | R | 42 | W 3-6 | vs OAK | 10 | 583 | L | 6.1 | 6 | 4 | 4 | 2 | 1 | 7 | 0 | 0 | 0 | -- | 3-3 | 3.77 | 1.42 |
| 1980-05-31 | Doc Medich | R | 31 | W 3-4 | vs OAK | 8 | 212 | L | 7.1 | 8 | 4 | 4 | 0 | 2 | 2 | 0 | 0 | 0 | -- | 4-3 | 4.78 | 1.39 |
| 1980-06-01 | Danny Darwin | R | 25 | L 7-3 | vs OAK | 2 | 9 | W | 8.2 | 12 | 3 | 2 | 0 | 3 | 4 | 0 | 0 | 0 | -- | 4-1 | 2.14 | 1.48 |
| 1980-06-02 | Jon Matlack | L | 30 | L 1-1 | @ CHA | 11 | 256 | - | 5.1 | 3 | 1 | 1 | 0 | 0 | 4 | 0 | 0 | 0 | -- | 3-1 | 3.00 | 1.10 |
| 1980-06-03 | Gaylord Perry | R | 42 | L 4-5 | @ CHA | 11 | 584 | - | 6.0 | 5 | 4 | 1 | 0 | 2 | 5 | 0 | 0 | 0 | -- | 3-3 | 3.57 | 1.40 |
| 1980-06-04 | Doc Medich | R | 31 | W 4-3 | @ CHA | 9 | 213 | W | 7.2 | 8 | 3 | 3 | 1 | 3 | 2 | 0 | 0 | 0 | -- | 5-3 | 4.66 | 1.41 |
| 1980-06-04 | Dave Rajsich | L | 29 | L 1-5 | @ CHA | 1 | 6 | L | 5.0 | 6 | 4 | 4 | 1 | 3 | 1 | 0 | 0 | 0 | -- | 0-1 | 6.00 | 1.41 |
| 1980-06-05 | Jim Kern | R | 31 | W 0-8 | vs KCA | 1 | 13 | L | 4.2 | 8 | 5 | 5 | 2 | 3 | 4 | 0 | 0 | 0 | -- | 2-8 | 5.40 | 1.87 |
| 1980-06-06 | Jon Matlack | L | 30 | W 2-4 | vs KCA | 12 | 257 | L | 9.0 | 11 | 4 | 4 | 0 | 3 | 9 | 0 | 0 | 0 | -- | 3-2 | 3.10 | 1.15 |
| 1980-06-07 | Gaylord Perry | R | 42 | W 2-7 | vs KCA | 12 | 585 | L | 4.0 | 6 | 5 | 5 | 1 | 2 | 2 | 0 | 0 | 0 | -- | 3-4 | 4.00 | 1.43 |
| 1980-06-08 | Doc Medich | R | 31 | W 4-5 | vs KCA | 10 | 214 | - | 7.1 | 11 | 3 | 3 | 0 | 1 | 2 | 0 | 0 | 0 | -- | 5-3 | 4.50 | 1.42 |
| 1980-06-10 | Fergie Jenkins | R | 36 | W 3-1 | @ MIL | 11 | 497 | W | 9.0 | 5 | 1 | 1 | 1 | 1 | 5 | 0 | 0 | 0 | -- | 4-4 | 3.16 | 1.11 |
| 1980-06-11 | Jon Matlack | L | 30 | L 1-7 | @ MIL | 13 | 258 | L | 7.0 | 8 | 5 | 5 | 2 | 0 | 2 | 0 | 0 | 0 | -- | 3-3 | 3.35 | 1.15 |
| 1980-06-12 | Gaylord Perry | R | 42 | L 1-8 | @ MIL | 13 | 586 | L | 6.0 | 10 | 4 | 1 | 0 | 1 | 6 | 0 | 0 | 0 | -- | 3-5 | 3.81 | 1.46 |
| 1980-06-13 | Doc Medich | R | 32 | W 6-3 | @ TOR | 11 | 215 | W | 8.2 | 9 | 3 | 2 | 0 | 3 | 3 | 0 | 0 | 0 | -- | 6-3 | 4.25 | 1.43 |
| 1980-06-14 | Brian Allard | R | 22 | L 6-7 | @ TOR | 1 | 5 | - | 2.1 | 5 | 3 | 3 | 0 | 3 | 2 | 0 | 0 | 0 | -- | 0-0 | 3.86 | 1.57 |
| 1980-06-15 | Fergie Jenkins | R | 37 | L 3-5 | @ TOR | 12 | 498 | L | 8.0 | 8 | 5 | 5 | 1 | 3 | 6 | 0 | 0 | 0 | -- | 4-5 | 3.40 | 1.13 |
| 1980-06-16 | Jon Matlack | L | 30 | W 6-3 | @ KCA | 14 | 259 | - | 7.2 | 5 | 3 | 3 | 1 | 3 | 0 | 0 | 0 | 0 | -- | 3-3 | 3.39 | 1.15 |
| 1980-06-17 | Gaylord Perry | R | 42 | L 2-3 | @ KCA | 14 | 587 | L | 8.0 | 8 | 3 | 3 | 0 | 2 | 3 | 0 | 0 | 0 | -- | 3-6 | 3.77 | 1.44 |
| 1980-06-18 | Doc Medich | R | 32 | L 8-1 | vs MIL | 12 | 216 | W | 9.0 | 6 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | -- | 7-3 | 3.89 | 1.35 |
| 1980-06-19 | Brian Allard | R | 22 | W 4-10 | vs MIL | 2 | 6 | L | 3.2 | 5 | 6 | 4 | 0 | 2 | 1 | 0 | 0 | 0 | -- | 0-1 | 6.30 | 1.80 |
| 1980-06-20 | Fergie Jenkins | R | 37 | L 5-2 | vs TOR | 13 | 499 | W | 9.0 | 5 | 2 | 2 | 1 | 0 | 5 | 0 | 0 | 0 | -- | 5-5 | 3.26 | 1.08 |
| 1980-06-21 | Jon Matlack | L | 30 | L 2-1 | vs TOR | 15 | 260 | W | 9.0 | 7 | 1 | 0 | 0 | 1 | 8 | 0 | 0 | 0 | -- | 4-3 | 3.11 | 1.13 |
| 1980-06-22 | Gaylord Perry | R | 42 | W 5-6 | vs TOR | 15 | 588 | - | 7.0 | 4 | 1 | 1 | 0 | 2 | 7 | 0 | 0 | 0 | -- | 3-6 | 3.58 | 1.40 |
| 1980-06-24 | Doc Medich | R | 32 | L 5-4 | vs SEA | 13 | 217 | - | 7.0 | 9 | 4 | 4 | 0 | 1 | 3 | 0 | 0 | 0 | -- | 7-3 | 3.99 | 1.35 |
| 1980-06-25 | Fergie Jenkins | R | 37 | L 6-1 | vs SEA | 14 | 500 | W | 9.0 | 9 | 1 | 1 | 0 | 1 | 2 | 0 | 0 | 0 | -- | 6-5 | 3.06 | 1.08 |
| 1980-06-26 | Jon Matlack | L | 30 | W 4-8 | vs SEA | 16 | 261 | L | 3.1 | 8 | 6 | 5 | 1 | 1 | 3 | 0 | 0 | 0 | -- | 4-4 | 3.39 | 1.17 |
| 1980-06-27 | Gaylord Perry | R | 42 | L 5-0 | vs MIN | 16 | 589 | W | 9.0 | 4 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | -- | 4-6 | 3.26 | 1.31 |
| 1980-06-28 | Steve Comer | R | 26 | L 11-3 | vs MIN | 7 | 54 | W | 5.0 | 2 | 1 | 1 | 0 | 3 | 1 | 0 | 0 | 0 | -- | 2-3 | 8.04 | 2.00 |
| 1980-06-29 | Doc Medich | R | 32 | W 3-5 | vs MIN | 14 | 218 | L | 4.0 | 9 | 4 | 3 | 0 | 2 | 2 | 0 | 0 | 0 | -- | 7-4 | 4.11 | 1.41 |
| 1980-06-30 | Fergie Jenkins | R | 37 | W 11-5 | @ SEA | 15 | 501 | W | 6.0 | 9 | 3 | 3 | 1 | 1 | 1 | 0 | 0 | 0 | -- | 7-5 | 3.14 | 1.11 |
| 1980-07-01 | Jon Matlack | L | 30 | L 5-6 | @ SEA | 17 | 262 | - | 6.1 | 8 | 4 | 4 | 1 | 2 | 3 | 0 | 0 | 0 | -- | 4-4 | 3.53 | 1.19 |
| 1980-07-02 | Gaylord Perry | R | 42 | W 6-3 | @ SEA | 17 | 590 | W | 9.0 | 7 | 3 | 3 | 1 | 3 | 10 | 0 | 0 | 0 | -- | 5-6 | 3.24 | 1.30 |
| 1980-07-03 | Steve Comer | R | 26 | L 3-10 | @ MIN | 8 | 55 | L | 2.1 | 7 | 5 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | -- | 2-4 | 9.00 | 2.10 |
| 1980-07-04 | Doc Medich | R | 32 | W 4-3 | @ MIN | 15 | 219 | - | 6.2 | 7 | 3 | 3 | 1 | 1 | 1 | 0 | 0 | 0 | -- | 7-4 | 4.09 | 1.39 |
| 1980-07-05 | Fergie Jenkins | R | 37 | L 1-2 | @ MIN | 16 | 502 | L | 8.0 | 5 | 2 | 2 | 1 | 1 | 9 | 0 | 0 | 0 | -- | 7-6 | 3.08 | 1.09 |
| 1980-07-06 | Jon Matlack | L | 30 | L 1-4 | @ MIN | 18 | 263 | L | 5.2 | 9 | 4 | 4 | 0 | 1 | 4 | 0 | 0 | 0 | -- | 4-5 | 3.64 | 1.21 |
| 1980-07-10 | Fergie Jenkins | R | 37 | W 5-13 | vs NYA | 17 | 503 | L | 0.1 | 5 | 8 | 8 | 0 | 3 | 0 | 0 | 0 | 0 | -- | 7-7 | 3.71 | 1.16 |
| 1980-07-11 | Jon Matlack | L | 30 | L 10-8 | vs NYA | 19 | 264 | W | 6.2 | 12 | 7 | 3 | 1 | 1 | 2 | 0 | 0 | 0 | -- | 5-5 | 3.68 | 1.26 |
| 1980-07-12 | Gaylord Perry | R | 42 | W 8-9 | vs CLE | 18 | 591 | L | 4.0 | 6 | 6 | 6 | 0 | 3 | 3 | 0 | 0 | 0 | -- | 5-7 | 3.60 | 1.33 |
| 1980-07-13 | Doc Medich | R | 32 | L 12-2 | vs CLE | 16 | 220 | W | 9.0 | 5 | 2 | 0 | 0 | 4 | 2 | 0 | 0 | 0 | -- | 8-4 | 3.68 | 1.35 |
| 1980-07-14 | Steve Comer | R | 26 | L 4-2 | vs CLE | 9 | 56 | - | 5.1 | 5 | 2 | 2 | 0 | 3 | 0 | 0 | 0 | 0 | -- | 2-4 | 8.00 | 1.97 |
| 1980-07-15 | Fergie Jenkins | R | 37 | W 1-2 | vs CHA | 18 | 504 | L | 8.0 | 7 | 2 | 2 | 1 | 1 | 13 | 0 | 0 | 0 | -- | 7-8 | 3.61 | 1.15 |
| 1980-07-16 | Jon Matlack | L | 30 | L 11-3 | vs CHA | 20 | 265 | W | 6.0 | 6 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | -- | 6-5 | 3.59 | 1.26 |
| 1980-07-17 | Gaylord Perry | R | 42 | L 3-2 | vs CHA | 19 | 592 | - | 8.1 | 6 | 2 | 2 | 1 | 2 | 4 | 0 | 0 | 0 | -- | 5-7 | 3.51 | 1.31 |
| 1980-07-18 | Doc Medich | R | 32 | L 7-8 | @ BAL | 17 | 221 | - | 6.0 | 7 | 2 | 2 | 0 | 2 | 2 | 0 | 0 | 0 | -- | 8-4 | 3.65 | 1.36 |
| 1980-07-19 | Steve Comer | R | 27 | W 11-8 | @ BAL | 10 | 57 | - | 2.2 | 5 | 3 | 3 | 0 | 3 | 1 | 0 | 0 | 0 | -- | 2-4 | 8.29 | 2.08 |
| 1980-07-20 | Fergie Jenkins | R | 37 | W 7-1 | @ BAL | 19 | 505 | W | 9.0 | 8 | 1 | 1 | 1 | 1 | 7 | 0 | 0 | 0 | -- | 8-8 | 3.44 | 1.14 |
| 1980-07-21 | Jon Matlack | L | 31 | W 5-3 | @ BOS | 21 | 266 | W | 7.0 | 4 | 1 | 1 | 1 | 2 | 4 | 0 | 0 | 0 | -- | 7-5 | 3.48 | 1.24 |
| 1980-07-22 | Gaylord Perry | R | 42 | W 4-3 | @ BOS | 20 | 593 | - | 6.2 | 6 | 2 | 1 | 0 | 1 | 5 | 0 | 0 | 0 | -- | 5-7 | 3.39 | 1.29 |
| 1980-07-23 | Doc Medich | R | 32 | L 5-12 | @ BOS | 18 | 222 | - | 5.2 | 6 | 3 | 2 | 0 | 4 | 3 | 0 | 0 | 0 | -- | 8-4 | 3.61 | 1.38 |
| 1980-07-25 | Steve Comer | R | 27 | W 6-4 | @ CHA | 11 | 58 | - | 3.1 | 7 | 4 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | -- | 2-4 | 7.93 | 2.07 |
| 1980-07-26 | Fergie Jenkins | R | 37 | L 3-4 | @ CHA | 20 | 506 | L | 8.0 | 8 | 4 | 4 | 2 | 3 | 1 | 0 | 0 | 0 | -- | 8-9 | 3.50 | 1.15 |
| 1980-07-26 | Gaylord Perry | R | 42 | L 1-1 | @ CHA | 21 | 594 | - | 5.0 | 5 | 1 | 1 | 0 | 1 | 3 | 0 | 0 | 0 | -- | 5-7 | 3.33 | 1.29 |
| 1980-07-27 | Doc Medich | R | 32 | L 2-3 | @ CHA | 19 | 223 | L | 8.0 | 5 | 3 | 3 | 0 | 2 | 4 | 0 | 0 | 0 | -- | 8-5 | 3.60 | 1.35 |
| 1980-07-27 | Jon Matlack | L | 31 | W 4-3 | @ CHA | 22 | 267 | - | 6.1 | 3 | 2 | 2 | 1 | 0 | 4 | 0 | 0 | 0 | -- | 7-5 | 3.43 | 1.20 |
| 1980-07-29 | Charlie Hough | R | 33 | W 3-4 | vs BAL | 2 | 17 | L | 9.0 | 8 | 4 | 3 | 1 | 4 | 8 | 0 | 0 | 0 | -- | 2-4 | 5.19 | 1.77 |
| 1980-07-30 | Gaylord Perry | R | 42 | W 2-3 | vs BAL | 22 | 595 | L | 9.0 | 8 | 3 | 2 | 0 | 3 | 6 | 0 | 0 | 0 | -- | 5-8 | 3.25 | 1.28 |
| 1980-07-31 | Fergie Jenkins | R | 37 | L 7-4 | vs BAL | 21 | 507 | W | 8.2 | 8 | 4 | 4 | 1 | 5 | 7 | 0 | 0 | 0 | -- | 9-9 | 3.53 | 1.17 |
| 1980-08-01 | Doc Medich | R | 32 | L 7-5 | vs BOS | 20 | 224 | W | 5.2 | 11 | 4 | 4 | 1 | 0 | 1 | 0 | 0 | 0 | -- | 9-5 | 3.73 | 1.38 |
| 1980-08-02 | Ed Figueroa | R | 32 | W 0-1 | vs BOS | 10 | 171 | L | 7.0 | 7 | 1 | 1 | 0 | 1 | 3 | 0 | 0 | 0 | -- | 3-4 | 6.37 | 1.88 |
| 1980-08-03 | Jon Matlack | L | 31 | W 4-6 | vs BOS | 23 | 268 | L | 4.2 | 13 | 6 | 6 | 1 | 1 | 0 | 0 | 0 | 0 | -- | 7-6 | 3.69 | 1.26 |
| 1980-08-04 | Gaylord Perry | R | 42 | L 4-10 | @ NYA | 23 | 596 | L | 3.1 | 9 | 6 | 6 | 2 | 1 | 2 | 0 | 0 | 0 | -- | 5-9 | 3.55 | 1.33 |
| 1980-08-05 | Fergie Jenkins | R | 37 | W 8-1 | @ NYA | 22 | 508 | W | 8.2 | 10 | 1 | 1 | 0 | 1 | 3 | 0 | 0 | 0 | -- | 10-9 | 3.38 | 1.17 |
| 1980-08-06 | Doc Medich | R | 32 | L 1-2 | @ NYA | 21 | 225 | L | 7.0 | 6 | 2 | 2 | 1 | 3 | 1 | 0 | 0 | 0 | -- | 9-6 | 3.68 | 1.37 |
| 1980-08-08 | Ed Figueroa | R | 32 | W 0-8 | vs DET | 11 | 172 | L | 4.1 | 7 | 4 | 3 | 1 | 2 | 1 | 0 | 0 | 0 | -- | 3-5 | 6.39 | 1.90 |
| 1980-08-09 | Jon Matlack | L | 31 | L 4-3 | vs DET | 24 | 269 | - | 7.1 | 7 | 3 | 1 | 0 | 3 | 6 | 0 | 0 | 0 | -- | 7-6 | 3.57 | 1.26 |
| 1980-08-10 | Gaylord Perry | R | 42 | L 4-2 | vs DET | 24 | 597 | W | 8.0 | 9 | 2 | 1 | 1 | 1 | 7 | 0 | 0 | 0 | -- | 6-9 | 3.43 | 1.32 |
| 1980-08-12 | Fergie Jenkins | R | 37 | L 1-2 | @ CLE | 23 | 509 | L | 7.1 | 6 | 2 | 2 | 1 | 1 | 7 | 0 | 0 | 0 | -- | 10-10 | 3.35 | 1.16 |
| 1980-08-13 | Doc Medich | R | 32 | L 3-14 | @ CLE | 22 | 226 | L | 2.1 | 7 | 5 | 5 | 0 | 1 | 1 | 0 | 0 | 0 | -- | 9-7 | 3.91 | 1.40 |
| 1980-08-14 | Ed Figueroa | R | 32 | L 2-7 | @ CLE | 12 | 173 | L | 4.0 | 12 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | -- | 3-6 | 6.53 | 1.96 |
| 1980-08-15 | Jon Matlack | L | 31 | W 6-2 | @ DET | 25 | 270 | W | 9.0 | 13 | 2 | 2 | 0 | 1 | 7 | 0 | 0 | 0 | -- | 8-6 | 3.49 | 1.28 |
| 1980-08-16 | Ken Clay | R | 26 | W 12-5 | @ DET | 1 | 15 | W | 5.2 | 7 | 3 | 3 | 1 | 2 | 2 | 0 | 0 | 0 | -- | 1-0 | 4.50 | 1.50 |
| 1980-08-17 | Fergie Jenkins | R | 37 | W 9-3 | @ DET | 24 | 510 | W | 9.0 | 6 | 3 | 2 | 1 | 2 | 9 | 0 | 0 | 0 | -- | 11-10 | 3.28 | 1.15 |
| 1980-08-17 | Doc Medich | R | 32 | W 12-6 | @ DET | 23 | 227 | W | 7.2 | 5 | 5 | 4 | 1 | 6 | 3 | 0 | 0 | 0 | -- | 10-7 | 3.97 | 1.41 |
| 1980-08-18 | Ed Figueroa | R | 32 | W 3-6 | vs KCA | 13 | 174 | L | 2.1 | 7 | 4 | 4 | 1 | 1 | 0 | 0 | 0 | 0 | -- | 3-7 | 6.75 | 1.99 |
| 1980-08-19 | Jon Matlack | L | 31 | W 3-4 | vs KCA | 26 | 271 | - | 8.1 | 5 | 3 | 2 | 0 | 1 | 3 | 0 | 0 | 0 | -- | 8-6 | 3.43 | 1.25 |
| 1980-08-20 | Ken Clay | R | 26 | W 3-5 | vs KCA | 2 | 16 | - | 9.1 | 8 | 3 | 3 | 1 | 3 | 3 | 0 | 0 | 0 | -- | 1-0 | 3.60 | 1.33 |
| 1980-08-22 | Fergie Jenkins | R | 37 | L 12-6 | vs MIL | 25 | 511 | - | 4.1 | 10 | 3 | 3 | 0 | 0 | 2 | 0 | 0 | 0 | -- | 11-10 | 3.36 | 1.18 |
| 1980-08-22 | Doc Medich | R | 32 | W 3-8 | vs MIL | 24 | 228 | L | 1.2 | 7 | 4 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | -- | 10-8 | 4.15 | 1.44 |
| 1980-08-23 | Ed Figueroa | R | 32 | L 7-5 | vs MIL | 14 | 175 | - | 6.0 | 8 | 4 | 3 | 1 | 3 | 2 | 0 | 0 | 0 | -- | 3-7 | 6.59 | 1.98 |
| 1980-08-24 | Jon Matlack | L | 31 | L 4-3 | vs MIL | 27 | 272 | - | 9.0 | 7 | 3 | 3 | 1 | 3 | 7 | 0 | 0 | 0 | -- | 8-6 | 3.41 | 1.25 |
| 1980-08-25 | Ken Clay | R | 26 | W 5-1 | @ TOR | 3 | 17 | W | 6.0 | 2 | 0 | 0 | 0 | 4 | 3 | 0 | 0 | 0 | -- | 2-0 | 2.57 | 1.24 |
| 1980-08-26 | Charlie Hough | R | 33 | W 8-0 | @ TOR | 3 | 18 | W | 9.0 | 5 | 0 | 0 | 0 | 2 | 7 | 0 | 0 | 0 | -- | 3-4 | 4.73 | 1.62 |
| 1980-08-27 | Doc Medich | R | 32 | L 4-6 | @ TOR | 25 | 229 | L | 3.0 | 8 | 6 | 6 | 0 | 2 | 2 | 0 | 0 | 0 | -- | 10-9 | 4.41 | 1.47 |
| 1980-08-28 | Fergie Jenkins | R | 37 | W 10-6 | @ KCA | 26 | 512 | - | 0.1 | 5 | 5 | 5 | 0 | 2 | 0 | 0 | 0 | 0 | -- | 11-10 | 3.59 | 1.21 |
| 1980-08-29 | Ed Figueroa | R | 32 | L 3-7 | @ KCA | 15 | 176 | L | 6.1 | 9 | 5 | 4 | 3 | 1 | 1 | 0 | 0 | 0 | -- | 3-8 | 6.55 | 1.95 |
| 1980-08-30 | Jon Matlack | L | 31 | W 7-5 | @ KCA | 28 | 273 | - | 6.2 | 12 | 3 | 3 | 0 | 1 | 2 | 0 | 0 | 0 | -- | 8-6 | 3.43 | 1.27 |
| 1980-08-31 | Ken Clay | R | 26 | L 3-4 | @ KCA | 4 | 18 | - | 4.2 | 4 | 3 | 3 | 0 | 7 | 0 | 0 | 0 | 0 | -- | 2-0 | 3.12 | 1.42 |
| 1980-09-01 | Doc Medich | R | 32 | L 9-1 | vs TOR | 26 | 230 | W | 9.0 | 7 | 1 | 1 | 0 | 0 | 6 | 0 | 0 | 0 | -- | 11-9 | 4.23 | 1.43 |
| 1980-09-02 | Fergie Jenkins | R | 37 | L 3-2 | vs TOR | 27 | 513 | W | 9.0 | 6 | 2 | 1 | 0 | 1 | 8 | 0 | 0 | 0 | -- | 12-10 | 3.47 | 1.19 |
| 1980-09-03 | Ed Figueroa | R | 32 | W 2-4 | vs TOR | 16 | 177 | L | 6.1 | 10 | 4 | 4 | 2 | 2 | 1 | 0 | 0 | 0 | -- | 3-9 | 6.51 | 1.96 |
| 1980-09-05 | Jon Matlack | L | 31 | W 6-5 | @ MIL | 29 | 274 | W | 6.2 | 8 | 5 | 5 | 2 | 0 | 4 | 0 | 0 | 0 | -- | 9-6 | 3.55 | 1.27 |
| 1980-09-06 | Ken Clay | R | 26 | L 2-6 | @ MIL | 5 | 19 | L | 2.1 | 3 | 1 | 1 | 0 | 3 | 2 | 0 | 0 | 0 | -- | 2-1 | 3.21 | 1.54 |
| 1980-09-07 | Doc Medich | R | 32 | W 7-2 | @ MIL | 27 | 231 | W | 8.2 | 13 | 2 | 2 | 0 | 0 | 5 | 0 | 0 | 0 | -- | 12-9 | 4.11 | 1.43 |
| 1980-09-08 | John Butcher | R | 24 | W 6-2 | @ OAK | 1 | 1 | W | 9.0 | 6 | 2 | 2 | 0 | 3 | 5 | 0 | 0 | 0 | -- | 1-0 | 2.00 | 1.00 |
| 1980-09-09 | Ed Figueroa | R | 32 | L 3-6 | @ OAK | 17 | 178 | L | 3.1 | 2 | 3 | 3 | 1 | 2 | 1 | 0 | 0 | 0 | -- | 3-10 | 6.52 | 1.92 |
| 1980-09-10 | Jon Matlack | L | 31 | L 1-3 | @ OAK | 30 | 275 | L | 8.0 | 7 | 3 | 3 | 1 | 3 | 5 | 0 | 0 | 0 | -- | 9-7 | 3.54 | 1.27 |
| 1980-09-12 | Doc Medich | R | 32 | L 4-8 | @ CAL | 28 | 232 | L | 0.2 | 3 | 5 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | -- | 12-10 | 4.17 | 1.46 |
| 1980-09-13 | John Butcher | R | 24 | L 1-10 | @ CAL | 2 | 2 | L | 4.0 | 8 | 7 | 4 | 2 | 2 | 5 | 0 | 0 | 0 | -- | 1-1 | 4.15 | 1.46 |
| 1980-09-14 | Ken Clay | R | 26 | L 1-3 | @ CAL | 6 | 20 | L | 6.0 | 8 | 3 | 3 | 1 | 3 | 3 | 0 | 0 | 0 | -- | 2-2 | 3.44 | 1.59 |
| 1980-09-15 | Jon Matlack | L | 31 | L 2-0 | vs OAK | 31 | 276 | W | 6.1 | 8 | 0 | 0 | 0 | 1 | 3 | 0 | 0 | 0 | -- | 10-7 | 3.43 | 1.27 |
| 1980-09-16 | Doc Medich | R | 32 | W 2-4 | vs OAK | 29 | 233 | - | 8.0 | 5 | 1 | 0 | 0 | 2 | 6 | 0 | 0 | 0 | -- | 12-10 | 3.98 | 1.43 |
| 1980-09-17 | John Butcher | R | 24 | W 4-6 | vs OAK | 3 | 3 | L | 2.1 | 5 | 4 | 4 | 0 | 2 | 2 | 0 | 0 | 0 | -- | 1-2 | 6.00 | 1.73 |
| 1980-09-18 | Ken Clay | R | 26 | L 10-6 | vs OAK | 7 | 21 | - | 2.2 | 6 | 4 | 4 | 1 | 2 | 1 | 0 | 0 | 0 | -- | 2-2 | 4.14 | 1.68 |
| 1980-09-19 | Jon Matlack | L | 31 | W 2-6 | vs CAL | 32 | 277 | L | 6.2 | 11 | 5 | 3 | 0 | 1 | 5 | 0 | 0 | 0 | -- | 10-8 | 3.46 | 1.29 |
| 1980-09-20 | Don Kainer | R | 25 | W 4-6 | vs CAL | 1 | 1 | - | 7.1 | 8 | 1 | 1 | 0 | 3 | 5 | 0 | 0 | 0 | -- | 0-0 | 2.25 | 1.88 |
| 1980-09-21 | Doc Medich | R | 32 | W 2-9 | vs CAL | 30 | 234 | L | 5.0 | 7 | 6 | 3 | 0 | 0 | 2 | 0 | 0 | 0 | -- | 12-11 | 4.02 | 1.43 |
| 1980-09-22 | John Butcher | R | 24 | L 0-1 | @ MIN | 4 | 4 | L | 7.1 | 3 | 1 | 1 | 0 | 2 | 3 | 0 | 0 | 0 | -- | 1-3 | 4.30 | 1.35 |
| 1980-09-23 | Ken Clay | R | 26 | L 2-8 | @ MIN | 8 | 22 | L | 6.1 | 5 | 7 | 5 | 0 | 5 | 3 | 0 | 0 | 0 | -- | 2-3 | 4.60 | 1.67 |
| 1980-09-24 | Jon Matlack | L | 31 | L 5-9 | @ MIN | 33 | 278 | L | 3.2 | 6 | 5 | 4 | 1 | 1 | 3 | 0 | 0 | 0 | -- | 10-9 | 3.55 | 1.30 |
| 1980-09-25 | Don Kainer | R | 25 | L 6-7 | @ SEA | 2 | 2 | - | 5.1 | 3 | 3 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | -- | 0-0 | 1.93 | 1.36 |
| 1980-09-26 | Fergie Jenkins | R | 37 | L 2-7 | @ SEA | 28 | 514 | L | 5.2 | 7 | 7 | 7 | 2 | 1 | 3 | 0 | 0 | 0 | -- | 12-11 | 3.70 | 1.20 |
| 1980-09-27 | Doc Medich | R | 32 | W 7-3 | @ SEA | 31 | 235 | W | 9.0 | 9 | 3 | 3 | 0 | 0 | 4 | 0 | 0 | 0 | -- | 13-11 | 3.97 | 1.41 |
| 1980-09-28 | John Butcher | R | 24 | W 4-1 | @ SEA | 5 | 5 | W | 6.0 | 7 | 1 | 1 | 0 | 2 | 6 | 0 | 0 | 0 | -- | 2-3 | 3.72 | 1.38 |
| 1980-10-02 | Jon Matlack | L | 31 | W 3-6 | vs MIN | 34 | 279 | L | 4.1 | 10 | 5 | 4 | 0 | 2 | 4 | 0 | 0 | 0 | -- | 10-10 | 3.65 | 1.33 |
| 1980-10-02 | Fergie Jenkins | R | 37 | W 1-4 | vs MIN | 29 | 515 | L | 5.2 | 8 | 4 | 4 | 1 | 2 | 4 | 0 | 0 | 0 | -- | 12-12 | 3.77 | 1.22 |
| 1980-10-03 | Doc Medich | R | 32 | L 6-2 | vs SEA | 32 | 236 | W | 7.0 | 6 | 2 | 2 | 0 | 2 | 5 | 0 | 0 | 0 | -- | 14-11 | 3.93 | 1.40 |
| 1980-10-04 | John Butcher | R | 24 | L 11-6 | vs SEA | 6 | 6 | W | 6.2 | 5 | 4 | 4 | 0 | 2 | 6 | 0 | 0 | 0 | -- | 3-3 | 4.11 | 1.34 |
| 1980-10-05 | Don Kainer | R | 25 | L 3-2 | vs SEA | 3 | 3 | - | 6.0 | 7 | 2 | 1 | 0 | 5 | 4 | 0 | 0 | 0 | -- | 0-0 | 1.80 | 1.55 |