| 1979-04-07 | @ DET | 1 | W 8-2 | 1-0 | 3 | 43,708 | Fergie Jenkins | Dave Rozema | Fergie Jenkins | Dave Rozema | | 8 | 2 | 6 |
| 1979-04-10 | vs CLE | 2 | W 5-0 | 2-0 | 2 | 22,424 | Doyle Alexander | Rick Wise | Jim Kern | Rick Wise | | 13 | 2 | 11 |
| 1979-04-11 | vs CLE | 3 | W 4-0 | 3-0 | 1 | 12,784 | Steve Comer | Eric Wilkins | Steve Comer | Eric Wilkins | | 17 | 2 | 15 |
| 1979-04-12 | vs CLE | 4 | W 5-3 | 4-0 | 1 | 15,777 | Fergie Jenkins | Rick Waits | Fergie Jenkins | Rick Waits | Sparky Lyle | 22 | 5 | 17 |
| 1979-04-13 | vs DET | 5 | W 5-4 | 5-0 | 1 | 23,095 | Dock Ellis | Dave Rozema | Jim Kern | Sheldon Burnside | Sparky Lyle | 27 | 9 | 18 |
| 1979-04-14 | vs DET | 6 | W 7-5 | 6-0 | 1 | 30,014 | Doyle Alexander | Milt Wilcox | Sparky Lyle | Steve Baker | | 34 | 14 | 20 |
| 1979-04-15 | vs DET | 7 | L 6-11 | 6-1 | 1 | 19,353 | Steve Comer | Kip Young | Sheldon Burnside | Sparky Lyle | | 40 | 25 | 15 |
| 1979-04-17 | @ CLE | 8 | W 6-2 | 7-1 | 1 | 6,910 | Fergie Jenkins | Rick Waits | Fergie Jenkins | Rick Waits | Jim Kern | 46 | 27 | 19 |
| 1979-04-18 | @ CLE | 9 | L 4-6 | 7-2 | 1 | 6,192 | Doyle Alexander | Eric Wilkins | Sid Monge | Doc Medich | | 50 | 33 | 17 |
| 1979-04-20 | @ NYA | 10 | L 3-5 | 7-3 | 2 | 26,651 | Steve Comer | Ed Figueroa | Ed Figueroa | Steve Comer | Dick Tidrow | 53 | 38 | 15 |
| 1979-04-21 | @ NYA | 11 | W 5-0 | 8-3 | 2 | 25,530 | Fergie Jenkins | Catfish Hunter | Fergie Jenkins | Catfish Hunter | | 58 | 38 | 20 |
| 1979-04-22 | @ NYA | 12 | L 1-5 | 8-4 | 2 | 35,250 | Dock Ellis | Ron Guidry | Ron Guidry | Dock Ellis | | 59 | 43 | 16 |
| 1979-04-23 | vs TOR | 13 | W 5-0 | 9-4 | 2 | 12,661 | Doyle Alexander | Jim Clancy | Doyle Alexander | Jim Clancy | Jim Kern | 64 | 43 | 21 |
| 1979-04-24 | vs TOR | 14 | L 0-2 | 9-5 | 2 | 14,411 | Steve Comer | Dave Lemanczyk | Dave Lemanczyk | Steve Comer | | 64 | 45 | 19 |
| 1979-04-25 | vs TOR | 15 | W 4-3 | 10-5 | 1 | 15,731 | Fergie Jenkins | Mark Lemongello | Sparky Lyle | Jesse Jefferson | | 68 | 48 | 20 |
| 1979-04-27 | @ CHA | 16 | L 0-11 | 10-6 | 3 | 12,056 | Doyle Alexander | Ross Baumgarten | Ross Baumgarten | Doyle Alexander | | 68 | 59 | 9 |
| 1979-04-28 | @ CHA | 17 | L 2-3 | 10-7 | 3 | 15,703 | Steve Comer | Francisco Barrios | Francisco Barrios | Steve Comer | Mike Proly | 70 | 62 | 8 |
| 1979-04-29 | @ CHA | 18 | W 10-0 | 11-7 | 3 | 9,366 | Dock Ellis | Rich Wortham | Dock Ellis | Rich Wortham | Jim Kern | 80 | 62 | 18 |
| 1979-04-30 | @ KCA | 19 | W 8-7 | 12-7 | 3 | 23,634 | Fergie Jenkins | Rich Gale | Jim Kern | Steve Busby | Sparky Lyle | 88 | 69 | 19 |
| 1979-05-01 | @ KCA | 20 | L 3-9 | 12-8 | 3 | 20,767 | Jon Matlack | Paul Splittorff | Paul Splittorff | Jon Matlack | Marty Pattin | 91 | 78 | 13 |
| 1979-05-02 | @ KCA | 21 | W 3-2 | 13-8 | 3 | 20,155 | Steve Comer | Dennis Leonard | Steve Comer | Dennis Leonard | Sparky Lyle | 94 | 80 | 14 |
| 1979-05-04 | vs CHA | 22 | L 5-7 | 14-9 | 3 | 0 | Doyle Alexander | Francisco Barrios | Francisco Barrios | Sparky Lyle | Mike Proly | 99 | 87 | 12 |
| 1979-05-04 | vs CHA | 23 | W 7-6 | 14-9 | 3 | 24,200 | Fergie Jenkins | Ross Baumgarten | Ed Farmer | Lerrin LaGrow | | 106 | 93 | 13 |
| 1979-05-05 | vs CHA | 24 | L 6-7 | 14-10 | 3 | 27,901 | Dock Ellis | Rich Wortham | Rich Wortham | Dock Ellis | Mike Proly | 112 | 100 | 12 |
| 1979-05-06 | vs CHA | 25 | L 0-3 | 14-11 | 3 | 12,501 | Jon Matlack | Ken Kravec | Ken Kravec | Jon Matlack | | 112 | 103 | 9 |
| 1979-05-07 | vs KCA | 26 | L 6-10 | 14-12 | 4 | 14,242 | Steve Comer | Dennis Leonard | Eduardo Rodriguez | Doc Medich | Marty Pattin | 118 | 113 | 5 |
| 1979-05-08 | vs KCA | 27 | W 8-7 | 15-12 | 3 | 14,400 | Ed Farmer | Larry Gura | Jim Kern | Larry Gura | | 126 | 120 | 6 |
| 1979-05-09 | vs KCA | 28 | L 3-4 | 15-13 | 4 | 18,324 | Fergie Jenkins | Rich Gale | Rich Gale | Fergie Jenkins | Renie Martin | 129 | 124 | 5 |
| 1979-05-11 | @ TOR | 29 | W 3-1 | 16-13 | 3 | 12,153 | Jon Matlack | Jim Clancy | Jon Matlack | Jim Clancy | | 132 | 125 | 7 |
| 1979-05-12 | @ TOR | 30 | W 3-1 | 17-13 | 3 | 14,109 | Steve Comer | Dave Lemanczyk | Steve Comer | Dave Lemanczyk | Sparky Lyle | 135 | 126 | 9 |
| 1979-05-13 | @ TOR | 31 | L 1-3 | 18-14 | 2 | 0 | Doyle Alexander | Mark Lemongello | Mark Lemongello | Doyle Alexander | | 136 | 129 | 7 |
| 1979-05-13 | @ TOR | 32 | W 7-5 | 18-14 | 2 | 16,531 | Ed Farmer | Phil Huffman | Ed Farmer | Phil Huffman | Sparky Lyle | 143 | 134 | 9 |
| 1979-05-14 | @ MIN | 33 | W 7-5 | 19-14 | 2 | 6,406 | Fergie Jenkins | Roger Erickson | Jim Kern | Mike Marshall | | 150 | 139 | 11 |
| 1979-05-15 | @ MIN | 34 | W 9-8 | 20-14 | 2 | 7,499 | Dock Ellis | Pete Redfern | Sparky Lyle | Mike Marshall | Jim Kern | 159 | 147 | 12 |
| 1979-05-16 | @ MIN | 35 | W 8-4 | 21-14 | 2 | 6,121 | Jon Matlack | Paul Hartzell | Jon Matlack | Paul Hartzell | Jim Kern | 167 | 151 | 16 |
| 1979-05-18 | @ SEA | 36 | L 5-13 | 21-15 | 3 | 5,948 | Steve Comer | Rick Honeycutt | John Montague | Steve Comer | | 172 | 164 | 8 |
| 1979-05-19 | @ SEA | 37 | L 0-4 | 21-16 | 3 | 13,109 | Fergie Jenkins | Floyd Bannister | Floyd Bannister | Fergie Jenkins | | 172 | 168 | 4 |
| 1979-05-20 | @ SEA | 38 | W 6-4 | 22-16 | 3 | 10,054 | Doyle Alexander | Mike Parrott | Doyle Alexander | Shane Rawley | Jim Kern | 178 | 172 | 6 |
| 1979-05-21 | vs MIN | 39 | L 6-7 | 22-17 | 3 | 11,601 | Jon Matlack | Paul Hartzell | Pete Redfern | Sparky Lyle | Mike Marshall | 184 | 179 | 5 |
| 1979-05-22 | vs MIN | 40 | W 4-3 | 23-17 | 3 | 11,955 | Steve Comer | Jerry Koosman | Jim Kern | Jerry Koosman | | 188 | 182 | 6 |
| 1979-05-23 | vs MIN | 41 | W 7-2 | 24-17 | 3 | 17,909 | Fergie Jenkins | Dave Goltz | Fergie Jenkins | Dave Goltz | | 195 | 184 | 11 |
| 1979-05-25 | vs SEA | 42 | L 2-3 | 24-19 | 3 | 0 | Doyle Alexander | Mike Parrott | Mike Parrott | Doyle Alexander | Shane Rawley | 197 | 187 | 10 |
| 1979-05-25 | vs SEA | 43 | L 3-5 | 24-19 | 3 | 26,765 | Dock Ellis | Rick Honeycutt | Rick Honeycutt | Dock Ellis | | 200 | 192 | 8 |
| 1979-05-26 | vs SEA | 44 | W 2-1 | 25-19 | 3 | 20,649 | Jon Matlack | Glenn Abbott | Jon Matlack | Glenn Abbott | | 202 | 193 | 9 |
| 1979-05-27 | vs SEA | 45 | W 7-3 | 26-19 | 3 | 17,320 | Steve Comer | Paul Mitchell | Steve Comer | Paul Mitchell | Jim Kern | 209 | 196 | 13 |
| 1979-05-28 | vs BOS | 46 | W 5-2 | 27-19 | 3 | 18,441 | Fergie Jenkins | Steve Renko | Fergie Jenkins | Steve Renko | Sparky Lyle | 214 | 198 | 16 |
| 1979-05-30 | vs BOS | 47 | W 3-2 | 28-19 | 2 | 16,618 | Dock Ellis | Mike Torrez | Jim Kern | Dick Drago | | 217 | 200 | 17 |
| 1979-05-31 | vs BOS | 48 | L 2-3 | 28-20 | 3 | 13,600 | Jon Matlack | Dennis Eckersley | Dick Drago | Sparky Lyle | | 219 | 203 | 16 |
| 1979-06-01 | vs BAL | 49 | W 4-2 | 29-20 | 1 | 18,761 | Steve Comer | Steve Stone | Steve Comer | Steve Stone | Jim Kern | 223 | 205 | 18 |
| 1979-06-02 | vs BAL | 50 | L 4-5 | 29-21 | 3 | 26,362 | Fergie Jenkins | Dennis Martinez | Tippy Martinez | Sparky Lyle | Don Stanhouse | 227 | 210 | 17 |
| 1979-06-03 | vs BAL | 51 | W 4-2 | 30-21 | 1 | 21,851 | Doyle Alexander | Jim Palmer | Doyle Alexander | Jim Palmer | Jim Kern | 231 | 212 | 19 |
| 1979-06-04 | @ BOS | 52 | L 5-13 | 30-22 | 2 | 27,698 | Dock Ellis | Mike Torrez | Mike Torrez | Dock Ellis | | 236 | 225 | 11 |
| 1979-06-05 | @ BOS | 53 | L 3-9 | 30-23 | 4 | 27,670 | Jon Matlack | Dennis Eckersley | Dennis Eckersley | Jon Matlack | | 239 | 234 | 5 |
| 1979-06-06 | @ MIL | 54 | L 3-4 | 30-24 | 4 | 15,347 | Steve Comer | Lary Sorensen | Lary Sorensen | Steve Comer | | 242 | 238 | 4 |
| 1979-06-07 | @ MIL | 55 | W 7-1 | 31-24 | 3 | 12,368 | Fergie Jenkins | Moose Haas | Fergie Jenkins | Moose Haas | | 249 | 239 | 10 |
| 1979-06-08 | @ BAL | 56 | L 0-3 | 31-25 | 3 | 47,539 | Doyle Alexander | Mike Flanagan | Mike Flanagan | Doyle Alexander | | 249 | 242 | 7 |
| 1979-06-09 | @ BAL | 57 | L 3-4 | 31-26 | 4 | 30,806 | Dock Ellis | Steve Stone | Steve Stone | Dock Ellis | Don Stanhouse | 252 | 246 | 6 |
| 1979-06-10 | @ BAL | 58 | L 4-5 | 31-27 | 4 | 22,658 | Jon Matlack | Dennis Martinez | Dennis Martinez | Jim Kern | | 256 | 251 | 5 |
| 1979-06-12 | vs MIL | 59 | W 7-6 | 32-27 | 2 | 15,743 | Steve Comer | Lary Sorensen | Jim Kern | Lary Sorensen | | 263 | 257 | 6 |
| 1979-06-13 | vs MIL | 60 | L 4-5 | 32-28 | 3 | 14,566 | Fergie Jenkins | Moose Haas | Moose Haas | Fergie Jenkins | Reggie Cleveland | 267 | 262 | 5 |
| 1979-06-14 | vs MIL | 61 | L 2-6 | 32-29 | 4 | 13,403 | Doyle Alexander | Bill Travers | Bill Travers | Doyle Alexander | | 269 | 268 | 1 |
| 1979-06-15 | vs NYA | 62 | W 9-5 | 33-29 | 4 | 35,452 | Jon Matlack | Ed Figueroa | Jon Matlack | Ed Figueroa | | 278 | 273 | 5 |
| 1979-06-16 | vs NYA | 63 | L 2-3 | 33-30 | 4 | 41,097 | Dave Rajsich | Luis Tiant | Ron Davis | Sparky Lyle | | 280 | 276 | 4 |
| 1979-06-17 | vs NYA | 64 | W 6-3 | 34-30 | 2 | 37,405 | Steve Comer | Catfish Hunter | Steve Comer | Catfish Hunter | | 286 | 279 | 7 |
| 1979-06-18 | @ CAL | 65 | L 0-5 | 34-31 | 4 | 37,096 | Fergie Jenkins | Nolan Ryan | Nolan Ryan | Fergie Jenkins | | 286 | 284 | 2 |
| 1979-06-19 | @ CAL | 66 | W 2-1 | 35-31 | 2 | 26,553 | John Henry Johnson | Jim Barr | John Henry Johnson | Jim Barr | Jim Kern | 288 | 285 | 3 |
| 1979-06-20 | @ CAL | 67 | L 4-5 | 35-32 | 3 | 26,895 | Jon Matlack | Dave Frost | Dave Frost | Jon Matlack | Mark Clear | 292 | 290 | 2 |
| 1979-06-21 | @ CAL | 68 | W 3-2 | 36-32 | 2 | 26,422 | Danny Darwin | Don Aase | Sparky Lyle | Dave LaRoche | | 295 | 292 | 3 |
| 1979-06-22 | @ OAK | 69 | L 5-6 | 36-33 | 3 | 1,865 | Steve Comer | Rick Langford | Rick Langford | Steve Comer | Dave Heaverlo | 300 | 298 | 2 |
| 1979-06-23 | @ OAK | 70 | W 8-5 | 37-33 | 3 | 2,512 | Fergie Jenkins | Mike Norris | Jim Kern | Bob Lacey | | 308 | 303 | 5 |
| 1979-06-24 | @ OAK | 71 | W 5-1 | 39-33 | 3 | 0 | John Henry Johnson | Matt Keough | John Henry Johnson | Matt Keough | | 313 | 304 | 9 |
| 1979-06-24 | @ OAK | 72 | W 7-2 | 39-33 | 3 | 4,752 | Doc Medich | Dave Hamilton | Doc Medich | Dave Hamilton | Jim Kern | 320 | 306 | 14 |
| 1979-06-26 | vs CAL | 73 | W 2-1 | 40-33 | 3 | 28,695 | Jon Matlack | Don Aase | Jon Matlack | Don Aase | Jim Kern | 322 | 307 | 15 |
| 1979-06-27 | vs CAL | 74 | W 4-2 | 41-33 | 2 | 28,899 | Steve Comer | Nolan Ryan | Steve Comer | Nolan Ryan | Jim Kern | 326 | 309 | 17 |
| 1979-06-28 | vs CAL | 75 | W 14-4 | 42-33 | 2 | 29,101 | Fergie Jenkins | Jim Barr | Fergie Jenkins | Jim Barr | | 340 | 313 | 27 |
| 1979-06-29 | vs OAK | 76 | W 5-3 | 43-33 | 1 | 30,210 | Danny Darwin | Matt Keough | Danny Darwin | Matt Keough | Sparky Lyle | 345 | 316 | 29 |
| 1979-06-30 | vs OAK | 77 | W 4-3 | 44-33 | 1 | 22,439 | John Henry Johnson | Dave Hamilton | Jim Kern | Jim Todd | | 349 | 319 | 30 |
| 1979-07-01 | vs OAK | 78 | L 12-13 | 44-34 | 1 | 16,819 | Jon Matlack | Steve McCatty | Rick Langford | Doc Medich | Jim Todd | 361 | 332 | 29 |
| 1979-07-02 | vs BAL | 79 | W 2-0 | 45-34 | 1 | 17,383 | Steve Comer | Dennis Martinez | Steve Comer | Dennis Martinez | | 363 | 332 | 31 |
| 1979-07-03 | vs BAL | 80 | W 4-0 | 46-34 | 1 | 27,981 | Fergie Jenkins | Steve Stone | Fergie Jenkins | Steve Stone | | 367 | 332 | 35 |
| 1979-07-04 | vs BAL | 81 | W 9-5 | 47-34 | 1 | 41,097 | Danny Darwin | Mike Flanagan | Danny Darwin | Mike Flanagan | Jim Kern | 376 | 337 | 39 |
| 1979-07-06 | vs TOR | 82 | L 1-5 | 47-35 | 2 | 19,539 | John Henry Johnson | Tom Underwood | Tom Underwood | John Henry Johnson | Tom Buskey | 377 | 342 | 35 |
| 1979-07-07 | vs TOR | 83 | W 2-0 | 48-35 | 2 | 23,935 | Doc Medich | Dave Lemanczyk | Doc Medich | Dave Lemanczyk | Jim Kern | 379 | 342 | 37 |
| 1979-07-08 | vs TOR | 84 | W 4-3 | 49-35 | 1 | 17,489 | Steve Comer | Balor Moore | Steve Comer | Balor Moore | Sparky Lyle | 383 | 345 | 38 |
| 1979-07-09 | @ CHA | 85 | L 4-5 | 49-36 | 2 | 22,279 | Fergie Jenkins | Ross Baumgarten | Ross Baumgarten | Fergie Jenkins | Randy Scarbery | 387 | 350 | 37 |
| 1979-07-10 | @ CHA | 86 | L 3-6 | 49-37 | 2 | 18,761 | John Henry Johnson | Rich Wortham | Rich Wortham | Jim Kern | Ed Farmer | 390 | 356 | 34 |
| 1979-07-11 | @ CHA | 87 | L 3-5 | 49-38 | 2 | 15,520 | Jerry Gleaton | Steve Trout | Steve Trout | Danny Darwin | | 393 | 361 | 32 |
| 1979-07-12 | @ KCA | 88 | W 6-2 | 50-38 | 2 | 27,834 | Doc Medich | Larry Gura | Doc Medich | Larry Gura | | 399 | 363 | 36 |
| 1979-07-13 | @ KCA | 89 | W 9-4 | 51-38 | 2 | 30,139 | Steve Comer | Dennis Leonard | Steve Comer | Dennis Leonard | Sparky Lyle | 408 | 367 | 41 |
| 1979-07-14 | @ KCA | 90 | W 7-3 | 52-38 | 2 | 39,282 | Fergie Jenkins | Rich Gale | Fergie Jenkins | Rich Gale | Jim Kern | 415 | 370 | 45 |
| 1979-07-15 | @ KCA | 91 | L 3-4 | 52-39 | 2 | 28,904 | John Henry Johnson | Paul Splittorff | Paul Splittorff | John Henry Johnson | | 418 | 374 | 44 |
| 1979-07-19 | vs CHA | 92 | L 6-9 | 52-41 | 2 | 0 | Danny Darwin | Steve Trout | Steve Trout | Dave Rajsich | Ed Farmer | 424 | 383 | 41 |
| 1979-07-19 | vs CHA | 93 | L 4-5 | 52-41 | 2 | 26,687 | Fergie Jenkins | Ken Kravec | Ken Kravec | Fergie Jenkins | Ed Farmer | 428 | 388 | 40 |
| 1979-07-20 | vs CHA | 94 | L 1-2 | 52-42 | 2 | 21,901 | John Henry Johnson | Rich Wortham | Rich Wortham | John Henry Johnson | Guy Hoffman | 429 | 390 | 39 |
| 1979-07-21 | vs KCA | 95 | W 4-1 | 53-42 | 2 | 36,258 | Doc Medich | Paul Splittorff | Doc Medich | Paul Splittorff | Jim Kern | 433 | 391 | 42 |
| 1979-07-22 | vs KCA | 96 | L 6-7 | 53-43 | 3 | 29,863 | Steve Comer | Larry Gura | Dan Quisenberry | Sparky Lyle | | 439 | 398 | 41 |
| 1979-07-23 | vs KCA | 97 | L 4-5 | 53-44 | 3 | 24,141 | Fergie Jenkins | Dennis Leonard | Dennis Leonard | Fergie Jenkins | Dan Quisenberry | 443 | 403 | 40 |
| 1979-07-25 | @ TOR | 98 | L 3-8 | 53-45 | 3 | 24,705 | John Henry Johnson | Dave Stieb | Dave Stieb | John Henry Johnson | Tom Buskey | 446 | 411 | 35 |
| 1979-07-26 | @ TOR | 99 | L 4-8 | 53-46 | 3 | 14,605 | Doc Medich | Tom Underwood | Tom Underwood | Doc Medich | | 450 | 419 | 31 |
| 1979-07-27 | vs BOS | 100 | W 11-2 | 54-46 | 3 | 27,970 | Steve Comer | Bob Stanley | Steve Comer | Bob Stanley | | 461 | 421 | 40 |
| 1979-07-28 | vs BOS | 101 | L 0-1 | 54-47 | 3 | 35,207 | Fergie Jenkins | Dennis Eckersley | Dennis Eckersley | Fergie Jenkins | | 461 | 422 | 39 |
| 1979-07-29 | vs BOS | 102 | L 2-3 | 54-48 | 3 | 22,298 | Doyle Alexander | Mike Torrez | Mike Torrez | Doyle Alexander | Dick Drago | 463 | 425 | 38 |
| 1979-07-30 | vs DET | 103 | L 4-6 | 54-49 | 3 | 14,297 | John Henry Johnson | Jack Morris | John Hiller | Danny Darwin | Aurelio Lopez | 467 | 431 | 36 |
| 1979-07-31 | vs DET | 104 | W 11-3 | 55-49 | 3 | 12,218 | Doc Medich | Dan Petry | Doc Medich | Dan Petry | | 478 | 434 | 44 |
| 1979-08-01 | vs DET | 105 | W 4-3 | 56-49 | 2 | 13,803 | Steve Comer | Milt Wilcox | Steve Comer | Milt Wilcox | Jim Kern | 482 | 437 | 45 |
| 1979-08-03 | @ CLE | 106 | W 8-3 | 57-49 | 2 | 21,920 | Fergie Jenkins | Rick Wise | Fergie Jenkins | Rick Wise | | 490 | 440 | 50 |
| 1979-08-04 | @ CLE | 107 | L 8-12 | 57-50 | 2 | 12,693 | John Henry Johnson | Rick Waits | Rick Waits | John Henry Johnson | Dan Spillner | 498 | 452 | 46 |
| 1979-08-05 | @ CLE | 108 | L 2-6 | 58-51 | 2 | 0 | Doc Medich | Len Barker | Len Barker | Doc Medich | | 500 | 458 | 42 |
| 1979-08-05 | @ CLE | 109 | W 14-3 | 58-51 | 2 | 45,534 | Danny Darwin | Mike Paxton | Danny Darwin | Mike Paxton | | 514 | 461 | 53 |
| 1979-08-07 | @ DET | 110 | L 1-3 | 58-53 | 3 | 0 | Steve Comer | Milt Wilcox | Milt Wilcox | Jim Kern | | 515 | 464 | 51 |
| 1979-08-07 | @ DET | 111 | L 2-8 | 58-53 | 3 | 27,009 | Dave Rajsich | Jack Billingham | Jack Billingham | Dave Rajsich | Aurelio Lopez | 517 | 472 | 45 |
| 1979-08-08 | @ DET | 112 | W 16-9 | 59-54 | 3 | 0 | Fergie Jenkins | Pat Underwood | Fergie Jenkins | Pat Underwood | | 533 | 481 | 52 |
| 1979-08-08 | @ DET | 113 | L 4-10 | 59-54 | 3 | 28,619 | John Henry Johnson | Bruce Robbins | Bruce Robbins | John Henry Johnson | | 537 | 491 | 46 |
| 1979-08-09 | @ DET | 114 | L 2-3 | 59-55 | 3 | 23,663 | Doc Medich | Mike Chris | Mike Chris | Doc Medich | Aurelio Lopez | 539 | 494 | 45 |
| 1979-08-10 | vs CLE | 115 | L 1-6 | 59-56 | 4 | 17,832 | Danny Darwin | Len Barker | Len Barker | Danny Darwin | | 540 | 500 | 40 |
| 1979-08-11 | vs CLE | 116 | W 5-2 | 60-56 | 4 | 21,902 | Brian Allard | Mike Paxton | Brian Allard | Mike Paxton | Jim Kern | 545 | 502 | 43 |
| 1979-08-12 | vs CLE | 117 | L 3-6 | 60-57 | 4 | 14,346 | Steve Comer | Dan Spillner | Dan Spillner | Steve Comer | Sid Monge | 548 | 508 | 40 |
| 1979-08-13 | @ NYA | 118 | L 2-3 | 60-58 | 4 | 24,977 | Fergie Jenkins | Ron Guidry | Ron Guidry | Fergie Jenkins | | 550 | 511 | 39 |
| 1979-08-14 | @ NYA | 119 | L 5-6 | 60-59 | 4 | 24,125 | Doc Medich | Luis Tiant | Luis Tiant | Jim Kern | Rich Gossage | 555 | 517 | 38 |
| 1979-08-15 | @ NYA | 120 | L 3-4 | 60-60 | 4 | 25,905 | Jerry Gleaton | Tommy John | Tommy John | Jerry Gleaton | Rich Gossage | 558 | 521 | 37 |
| 1979-08-16 | @ MIL | 121 | L 1-4 | 60-61 | 4 | 14,559 | Brian Allard | Lary Sorensen | Lary Sorensen | Brian Allard | | 559 | 525 | 34 |
| 1979-08-17 | @ MIL | 122 | L 1-5 | 60-62 | 4 | 24,074 | Steve Comer | Moose Haas | Moose Haas | Steve Comer | | 560 | 530 | 30 |
| 1979-08-18 | @ MIL | 123 | W 7-3 | 61-62 | 4 | 49,172 | Fergie Jenkins | Jim Slaton | Fergie Jenkins | Jim Slaton | Jim Kern | 567 | 533 | 34 |
| 1979-08-19 | @ MIL | 124 | L 3-4 | 61-63 | 4 | 37,376 | Doc Medich | Mike Caldwell | Mike Caldwell | Sparky Lyle | | 570 | 537 | 33 |
| 1979-08-20 | @ BAL | 125 | L 0-3 | 61-64 | 4 | 21,042 | Brian Allard | Mike Flanagan | Mike Flanagan | Brian Allard | | 570 | 540 | 30 |
| 1979-08-21 | @ BAL | 126 | W 2-1 | 62-64 | 4 | 14,891 | Steve Comer | Dennis Martinez | Steve Comer | Dennis Martinez | Jim Kern | 572 | 541 | 31 |
| 1979-08-23 | @ BAL | 127 | L 5-6 | 62-65 | 4 | 28,099 | Fergie Jenkins | Scott McGregor | Scott McGregor | Fergie Jenkins | Don Stanhouse | 577 | 547 | 30 |
| 1979-08-24 | vs MIL | 128 | L 6-9 | 62-66 | 4 | 23,505 | Doc Medich | Jim Slaton | Bob Galasso | Danny Darwin | | 583 | 556 | 27 |
| 1979-08-25 | vs MIL | 129 | L 2-5 | 62-67 | 4 | 16,181 | Brian Allard | Mike Caldwell | Mike Caldwell | Brian Allard | | 585 | 561 | 24 |
| 1979-08-26 | vs MIL | 130 | L 2-6 | 62-68 | 4 | 9,076 | Steve Comer | Bill Travers | Bill Travers | Steve Comer | | 587 | 567 | 20 |
| 1979-08-27 | vs NYA | 131 | L 4-7 | 62-69 | 4 | 24,922 | Fergie Jenkins | Tommy John | Tommy John | Fergie Jenkins | Ron Davis | 591 | 574 | 17 |
| 1979-08-28 | vs NYA | 132 | W 10-2 | 63-69 | 4 | 23,339 | John Henry Johnson | Ken Clay | Jim Kern | Ken Clay | | 601 | 576 | 25 |
| 1979-08-29 | vs NYA | 133 | L 5-7 | 63-70 | 4 | 18,117 | Dave Rajsich | Ron Guidry | Ron Guidry | Dave Rajsich | Rich Gossage | 606 | 583 | 23 |
| 1979-08-30 | @ BOS | 134 | W 6-0 | 64-70 | 4 | 32,399 | Doc Medich | Dennis Eckersley | Doc Medich | Dennis Eckersley | | 612 | 583 | 29 |
| 1979-08-31 | @ BOS | 135 | L 6-9 | 64-71 | 4 | 31,314 | Steve Comer | Mike Torrez | Mike Torrez | Steve Comer | Tom Burgmeier | 618 | 592 | 26 |
| 1979-09-01 | @ BOS | 136 | W 5-4 | 65-71 | 4 | 28,930 | Fergie Jenkins | Bob Stanley | Danny Darwin | Dick Drago | Jim Kern | 623 | 596 | 27 |
| 1979-09-02 | @ BOS | 137 | W 7-6 | 66-71 | 4 | 30,133 | Doyle Alexander | John Tudor | Jim Kern | Dick Drago | | 630 | 602 | 28 |
| 1979-09-03 | @ SEA | 138 | W 4-1 | 67-71 | 4 | 7,302 | Doc Medich | Floyd Bannister | Doc Medich | Floyd Bannister | Jim Kern | 634 | 603 | 31 |
| 1979-09-04 | @ SEA | 139 | W 5-2 | 68-71 | 4 | 5,759 | Steve Comer | Mike Parrott | Steve Comer | Mike Parrott | | 639 | 605 | 34 |
| 1979-09-05 | @ SEA | 140 | L 0-1 | 68-72 | 4 | 5,112 | Fergie Jenkins | Rob Dressler | Rob Dressler | Fergie Jenkins | Byron McLaughlin | 639 | 606 | 33 |
| 1979-09-07 | @ MIN | 141 | W 5-4 | 69-72 | 4 | 10,793 | Doyle Alexander | Geoff Zahn | Sparky Lyle | Mike Marshall | Jim Kern | 644 | 610 | 34 |
| 1979-09-08 | @ MIN | 142 | W 6-2 | 70-72 | 4 | 15,382 | Doc Medich | Jerry Koosman | Doc Medich | Jerry Koosman | Jim Kern | 650 | 612 | 38 |
| 1979-09-09 | @ MIN | 143 | W 6-5 | 71-72 | 4 | 9,261 | Steve Comer | Paul Hartzell | Steve Comer | Paul Hartzell | Jim Kern | 656 | 617 | 39 |
| 1979-09-10 | vs SEA | 144 | L 2-5 | 71-73 | 4 | 6,790 | Fergie Jenkins | Rob Dressler | Rob Dressler | Fergie Jenkins | Byron McLaughlin | 658 | 622 | 36 |
| 1979-09-11 | vs SEA | 145 | W 5-2 | 72-73 | 4 | 6,473 | Doyle Alexander | Roy Branch | Doyle Alexander | Roy Branch | Sparky Lyle | 663 | 624 | 39 |
| 1979-09-12 | vs SEA | 146 | W 13-3 | 73-73 | 4 | 6,258 | Doc Medich | Rick Honeycutt | Doc Medich | Rick Honeycutt | | 676 | 627 | 49 |
| 1979-09-13 | vs MIN | 147 | L 4-7 | 73-74 | 4 | 8,562 | Steve Comer | Paul Hartzell | Darrell Jackson | Jim Kern | | 680 | 634 | 46 |
| 1979-09-14 | vs MIN | 148 | W 5-3 | 74-74 | 4 | 10,082 | Fergie Jenkins | Dave Goltz | Fergie Jenkins | Dave Goltz | Sparky Lyle | 685 | 637 | 48 |
| 1979-09-15 | vs MIN | 149 | L 4-11 | 74-75 | 4 | 20,619 | Doyle Alexander | Geoff Zahn | Geoff Zahn | Doyle Alexander | | 689 | 648 | 41 |
| 1979-09-16 | vs MIN | 150 | L 2-6 | 74-76 | 4 | 6,853 | Doc Medich | Roger Erickson | Roger Erickson | Doc Medich | | 691 | 654 | 37 |
| 1979-09-17 | @ OAK | 151 | W 6-3 | 75-76 | 4 | 2,636 | Steve Comer | Mike Morgan | Steve Comer | Mike Morgan | Jim Kern | 697 | 657 | 40 |
| 1979-09-18 | @ OAK | 152 | W 9-5 | 76-76 | 4 | 750 | Fergie Jenkins | Steve McCatty | Fergie Jenkins | Steve McCatty | | 706 | 662 | 44 |
| 1979-09-19 | @ OAK | 153 | W 9-4 | 77-76 | 4 | 1,037 | Doyle Alexander | Brian Kingman | Doyle Alexander | Brian Kingman | | 715 | 666 | 49 |
| 1979-09-21 | @ CAL | 154 | W 3-1 | 78-76 | 4 | 37,450 | Doc Medich | Frank Tanana | Doc Medich | Mark Clear | Jim Kern | 718 | 667 | 51 |
| 1979-09-22 | @ CAL | 155 | L 1-3 | 78-77 | 4 | 33,730 | Steve Comer | Chris Knapp | Chris Knapp | Steve Comer | | 719 | 670 | 49 |
| 1979-09-23 | @ CAL | 156 | L 1-6 | 78-78 | 4 | 41,498 | Fergie Jenkins | Dave Frost | Dave Frost | Fergie Jenkins | | 720 | 676 | 44 |
| 1979-09-25 | vs OAK | 157 | W 5-3 | 79-78 | 4 | 6,322 | Doc Medich | Brian Kingman | Jim Kern | Brian Kingman | | 725 | 679 | 46 |
| 1979-09-26 | vs OAK | 158 | W 5-2 | 80-78 | 4 | 6,369 | Steve Comer | Rick Langford | Steve Comer | Rick Langford | | 730 | 681 | 49 |
| 1979-09-27 | vs OAK | 159 | W 4-3 | 81-78 | 4 | 6,360 | Larry McCall | Matt Keough | Larry McCall | Matt Keough | Sparky Lyle | 734 | 684 | 50 |
| 1979-09-28 | vs CAL | 160 | W 5-0 | 82-78 | 3 | 11,965 | Fergie Jenkins | Nolan Ryan | Fergie Jenkins | Nolan Ryan | | 739 | 684 | 55 |
| 1979-09-29 | vs CAL | 161 | W 6-3 | 83-78 | 3 | 19,167 | Doc Medich | Dave Frost | Dave Rajsich | Dave Frost | Jim Kern | 745 | 687 | 58 |
| 1979-09-30 | vs CAL | 162 | L 5-11 | 83-79 | 3 | 9,086 | Steve Comer | Chris Knapp | Chris Knapp | Steve Comer | | 750 | 698 | 52 |