| 1979-04-05 | @ NYA | 1 | W 5-1 | - | | 52,719 | Mike Caldwell | Ron Guidry | Mike Caldwell | Ron Guidry | | 5 | 1 | 4 |
| 1979-04-07 | @ NYA | 2 | W 4-3 | - | | 17,387 | Bill Travers | Ed Figueroa | Bob McClure | Ed Figueroa | Reggie Cleveland | 9 | 4 | 5 |
| 1979-04-08 | @ NYA | 3 | L 1-2 | - | | 26,954 | Lary Sorensen | Tommy John | Tommy John | Lary Sorensen | Rich Gossage | 10 | 6 | 4 |
| 1979-04-10 | vs BOS | 4 | W 3-0 | - | | 54,392 | Mike Caldwell | Dennis Eckersley | Mike Caldwell | Dennis Eckersley | | 13 | 6 | 7 |
| 1979-04-12 | vs BOS | 5 | L 10-12 | - | | 12,981 | Bill Travers | Mike Torrez | Dick Drago | Reggie Cleveland | Bob Stanley | 23 | 18 | 5 |
| 1979-04-13 | vs BAL | 6 | W 9-3 | - | | 14,040 | Lary Sorensen | Steve Stone | Lary Sorensen | Steve Stone | | 32 | 21 | 11 |
| 1979-04-14 | vs BAL | 7 | W 11-10 | - | | 21,393 | Jim Slaton | Dennis Martinez | Bob McClure | Tim Stoddard | | 43 | 31 | 12 |
| 1979-04-15 | vs BAL | 8 | W 4-2 | - | | 12,302 | Mike Caldwell | Jim Palmer | Mike Caldwell | Jim Palmer | | 47 | 33 | 14 |
| 1979-04-17 | @ BOS | 9 | L 5-6 | - | | 16,053 | Moose Haas | Mike Torrez | Tom Burgmeier | Reggie Cleveland | | 52 | 39 | 13 |
| 1979-04-18 | @ BOS | 10 | W 4-1 | - | | 19,213 | Lary Sorensen | Steve Renko | Lary Sorensen | Steve Renko | | 56 | 40 | 16 |
| 1979-04-19 | @ BOS | 11 | L 3-5 | - | | 20,485 | Jim Slaton | Chuck Rainey | Chuck Rainey | Jim Slaton | Dick Drago | 59 | 45 | 14 |
| 1979-04-20 | @ BAL | 12 | L 3-6 | - | | 11,234 | Mike Caldwell | Steve Stone | Steve Stone | Mike Caldwell | Don Stanhouse | 62 | 51 | 11 |
| 1979-04-21 | @ BAL | 13 | L 2-4 | - | | 10,021 | Bill Travers | Sammy Stewart | Sammy Stewart | Bill Travers | Don Stanhouse | 64 | 55 | 9 |
| 1979-04-22 | @ BAL | 14 | L 2-6 | - | | 0 | Moose Haas | Dennis Martinez | Dennis Martinez | Moose Haas | | 66 | 61 | 5 |
| 1979-04-22 | @ BAL | 15 | L 3-7 | - | | 22,598 | Lary Sorensen | Mike Flanagan | Mike Flanagan | Lary Sorensen | | 69 | 68 | 1 |
| 1979-04-26 | vs DET | 16 | W 5-1 | - | | 0 | Jim Slaton | Jack Billingham | Jim Slaton | Jack Billingham | | 74 | 69 | 5 |
| 1979-04-26 | vs DET | 17 | W 7-5 | - | | 8,839 | Jerry Augustine | Steve Baker | Reggie Cleveland | Steve Baker | Bill Castro | 81 | 74 | 7 |
| 1979-04-27 | @ TOR | 18 | W 8-5 | - | | 10,306 | Lary Sorensen | Phil Huffman | Lary Sorensen | Phil Huffman | Bob McClure | 89 | 79 | 10 |
| 1979-04-28 | @ TOR | 19 | W 11-8 | - | | 12,683 | Moose Haas | Tom Underwood | Bob McClure | Mike Willis | | 100 | 87 | 13 |
| 1979-04-29 | @ TOR | 20 | W 3-0 | - | | 0 | Mike Caldwell | Jim Clancy | Mike Caldwell | Jim Clancy | | 103 | 87 | 16 |
| 1979-04-29 | @ TOR | 21 | L 3-5 | - | | 16,083 | Bill Travers | Dave Lemanczyk | Dave Lemanczyk | Bill Travers | | 106 | 92 | 14 |
| 1979-04-30 | @ CLE | 22 | W 8-0 | - | | 3,811 | Jim Slaton | Eric Wilkins | Jim Slaton | Eric Wilkins | | 114 | 92 | 22 |
| 1979-05-01 | @ CLE | 23 | L 1-3 | - | | 3,583 | Lary Sorensen | Mike Paxton | Mike Paxton | Lary Sorensen | Sid Monge | 115 | 95 | 20 |
| 1979-05-02 | @ CLE | 24 | W 6-1 | - | | 4,859 | Moose Haas | Wayne Garland | Moose Haas | Wayne Garland | | 121 | 96 | 25 |
| 1979-05-03 | vs TOR | 25 | W 5-4 | - | | 7,801 | Bill Travers | Tom Underwood | Bill Travers | Tom Underwood | | 126 | 100 | 26 |
| 1979-05-04 | vs TOR | 26 | L 4-5 | - | | 28,896 | Mike Caldwell | Jim Clancy | Jim Clancy | Mike Caldwell | Dave Freisleben | 130 | 105 | 25 |
| 1979-05-05 | vs TOR | 27 | W 6-1 | - | | 14,910 | Jim Slaton | Dave Lemanczyk | Jim Slaton | Dave Lemanczyk | | 136 | 106 | 30 |
| 1979-05-06 | vs TOR | 28 | W 4-0 | - | | 53,962 | Lary Sorensen | Mark Lemongello | Lary Sorensen | Mark Lemongello | | 140 | 106 | 34 |
| 1979-05-08 | vs CLE | 29 | W 9-5 | - | | 12,959 | Moose Haas | Wayne Garland | Moose Haas | Wayne Garland | | 149 | 111 | 38 |
| 1979-05-09 | vs CLE | 30 | L 7-8 | - | | 10,829 | Mike Caldwell | Rick Waits | Rick Waits | Mike Caldwell | Sid Monge | 156 | 119 | 37 |
| 1979-05-10 | vs CLE | 31 | L 1-8 | - | | 10,864 | Jim Slaton | Eric Wilkins | Eric Wilkins | Jim Slaton | Don Hood | 157 | 127 | 30 |
| 1979-05-11 | @ DET | 32 | W 5-1 | - | | 42,563 | Lary Sorensen | Mark Fidrych | Lary Sorensen | Mark Fidrych | | 162 | 128 | 34 |
| 1979-05-12 | @ DET | 33 | W 3-2 | - | | 19,801 | Bill Travers | Dave Rozema | Jerry Augustine | Bruce Taylor | Bob McClure | 165 | 130 | 35 |
| 1979-05-13 | @ DET | 34 | L 2-6 | - | | 12,162 | Moose Haas | Jack Morris | Jack Morris | Moose Haas | Jack Billingham | 167 | 136 | 31 |
| 1979-05-15 | @ CAL | 35 | L 1-2 | - | | 21,235 | Mike Caldwell | Nolan Ryan | Mark Clear | Mike Caldwell | | 168 | 138 | 30 |
| 1979-05-16 | @ CAL | 36 | L 3-4 | - | | 21,533 | Jim Slaton | Dave Frost | Mark Clear | Jerry Augustine | | 171 | 142 | 29 |
| 1979-05-17 | @ CAL | 37 | L 5-8 | - | | 22,060 | Lary Sorensen | Don Aase | Jim Barr | Lary Sorensen | Dave LaRoche | 176 | 150 | 26 |
| 1979-05-18 | @ OAK | 38 | W 8-0 | - | | 2,556 | Bill Travers | Mike Norris | Bill Travers | Mike Norris | | 184 | 150 | 34 |
| 1979-05-19 | @ OAK | 39 | L 4-12 | - | | 2,422 | Moose Haas | John Henry Johnson | John Henry Johnson | Moose Haas | | 188 | 162 | 26 |
| 1979-05-20 | @ OAK | 40 | L 6-7 | - | | 0 | Mike Caldwell | Matt Keough | Dave Hamilton | Jerry Augustine | | 194 | 169 | 25 |
| 1979-05-20 | @ OAK | 41 | L 1-2 | - | | 5,729 | Jim Slaton | Craig Minetto | Steve McCatty | Jim Slaton | Dave Heaverlo | 195 | 171 | 24 |
| 1979-05-22 | vs CAL | 42 | W 7-1 | - | | 9,857 | Lary Sorensen | Dave Frost | Lary Sorensen | Dave Frost | | 202 | 172 | 30 |
| 1979-05-23 | vs CAL | 43 | W 1-0 | - | | 8,408 | Bill Travers | Don Aase | Bill Travers | Don Aase | | 203 | 172 | 31 |
| 1979-05-24 | vs CAL | 44 | W 9-6 | - | | 16,314 | Moose Haas | Chris Knapp | Jerry Augustine | Chris Knapp | | 212 | 178 | 34 |
| 1979-05-25 | vs OAK | 45 | W 3-2 | - | | 22,073 | Mike Caldwell | Craig Minetto | Mike Caldwell | Bob Lacey | | 215 | 180 | 35 |
| 1979-05-26 | vs OAK | 46 | W 8-4 | - | | 20,512 | Jim Slaton | Rick Langford | Jim Slaton | Rick Langford | | 223 | 184 | 39 |
| 1979-05-27 | vs OAK | 47 | L 1-2 | - | | 22,928 | Lary Sorensen | Steve McCatty | Steve McCatty | Lary Sorensen | Dave Heaverlo | 224 | 186 | 38 |
| 1979-05-28 | vs NYA | 48 | L 1-2 | - | | 39,291 | Bill Travers | Jim Beattie | Ron Davis | Bill Travers | | 225 | 188 | 37 |
| 1979-05-29 | vs NYA | 49 | W 7-3 | - | | 21,891 | Moose Haas | Catfish Hunter | Moose Haas | Catfish Hunter | | 232 | 191 | 41 |
| 1979-05-30 | vs NYA | 50 | L 2-5 | - | | 27,338 | Mike Caldwell | Tommy John | Ron Davis | Bob McClure | | 234 | 196 | 38 |
| 1979-05-31 | vs NYA | 51 | W 5-4 | - | | 24,707 | Jim Slaton | Luis Tiant | Jerry Augustine | Ray Burris | | 239 | 200 | 39 |
| 1979-06-01 | @ KCA | 52 | W 5-4 | - | | 32,469 | Lary Sorensen | Larry Gura | Lary Sorensen | Renie Martin | Jerry Augustine | 244 | 204 | 40 |
| 1979-06-02 | @ KCA | 53 | L 3-4 | - | | 32,795 | Bill Travers | Paul Splittorff | Paul Splittorff | Reggie Cleveland | | 247 | 208 | 39 |
| 1979-06-03 | @ KCA | 54 | L 1-6 | - | | 37,942 | Moose Haas | Marty Pattin | Marty Pattin | Moose Haas | | 248 | 214 | 34 |
| 1979-06-04 | @ CHA | 55 | W 6-0 | - | | 12,506 | Mike Caldwell | Ross Baumgarten | Mike Caldwell | Ross Baumgarten | | 254 | 214 | 40 |
| 1979-06-05 | @ CHA | 56 | W 5-3 | - | | 13,713 | Jim Slaton | Fred Howard | Jim Slaton | Fred Howard | Jerry Augustine | 259 | 217 | 42 |
| 1979-06-06 | vs TEX | 57 | W 4-3 | - | | 15,347 | Lary Sorensen | Steve Comer | Lary Sorensen | Steve Comer | | 263 | 220 | 43 |
| 1979-06-07 | vs TEX | 58 | L 1-7 | - | | 12,368 | Moose Haas | Fergie Jenkins | Fergie Jenkins | Moose Haas | | 264 | 227 | 37 |
| 1979-06-09 | vs CHA | 59 | L 2-6 | - | | 36,941 | Mike Caldwell | Fred Howard | Fred Howard | Mike Caldwell | Steve Trout | 266 | 233 | 33 |
| 1979-06-10 | vs CHA | 60 | L 3-13 | - | | 43,783 | Paul Mitchell | Francisco Barrios | Francisco Barrios | Paul Mitchell | Rich Hinton | 269 | 246 | 23 |
| 1979-06-12 | @ TEX | 61 | L 6-7 | - | | 15,743 | Lary Sorensen | Steve Comer | Jim Kern | Lary Sorensen | | 275 | 253 | 22 |
| 1979-06-13 | @ TEX | 62 | W 5-4 | - | | 14,566 | Moose Haas | Fergie Jenkins | Moose Haas | Fergie Jenkins | Reggie Cleveland | 280 | 257 | 23 |
| 1979-06-14 | @ TEX | 63 | W 6-2 | - | | 13,403 | Bill Travers | Doyle Alexander | Bill Travers | Doyle Alexander | | 286 | 259 | 27 |
| 1979-06-15 | vs KCA | 64 | L 11-14 | - | | 32,812 | Mike Caldwell | Paul Splittorff | Steve Mingori | Reggie Cleveland | Marty Pattin | 297 | 273 | 24 |
| 1979-06-16 | vs KCA | 65 | W 3-2 | - | | 43,784 | Jim Slaton | Steve Busby | Jim Slaton | Steve Busby | | 300 | 275 | 25 |
| 1979-06-17 | vs KCA | 66 | W 5-3 | - | | 28,100 | Lary Sorensen | Rich Gale | Lary Sorensen | Rich Gale | | 305 | 278 | 27 |
| 1979-06-19 | vs MIN | 67 | W 10-9 | - | | 17,741 | Moose Haas | Dave Goltz | Bob McClure | Mike Bacsik | Jerry Augustine | 315 | 287 | 28 |
| 1979-06-20 | vs MIN | 68 | W 8-3 | - | | 21,404 | Bill Travers | Paul Hartzell | Bill Travers | Paul Hartzell | | 323 | 290 | 33 |
| 1979-06-21 | vs MIN | 69 | W 3-2 | - | | 32,339 | Mike Caldwell | Gary Serum | Mike Caldwell | Gary Serum | | 326 | 292 | 34 |
| 1979-06-22 | @ SEA | 70 | W 15-8 | - | | 10,355 | Jim Slaton | Glenn Abbott | Jim Slaton | Glenn Abbott | | 341 | 300 | 41 |
| 1979-06-23 | @ SEA | 71 | L 3-8 | - | | 16,733 | Lary Sorensen | Mike Parrott | Mike Parrott | Lary Sorensen | | 344 | 308 | 36 |
| 1979-06-24 | @ SEA | 72 | W 7-4 | - | | 7,639 | Moose Haas | Rick Honeycutt | Bill Castro | John Montague | | 351 | 312 | 39 |
| 1979-06-26 | @ MIN | 73 | L 7-8 | - | | 21,711 | Bill Travers | Paul Hartzell | Mike Marshall | Jerry Augustine | | 358 | 320 | 38 |
| 1979-06-27 | @ MIN | 74 | W 9-8 | - | | 18,602 | Mike Caldwell | Gary Serum | Mike Caldwell | Gary Serum | Jerry Augustine | 367 | 328 | 39 |
| 1979-06-28 | @ MIN | 75 | W 6-5 | - | | 22,224 | Jim Slaton | Dave Goltz | Bill Castro | Mike Marshall | | 373 | 333 | 40 |
| 1979-06-29 | vs SEA | 76 | L 2-3 | - | | 16,843 | Lary Sorensen | Glenn Abbott | Glenn Abbott | Lary Sorensen | Shane Rawley | 375 | 336 | 39 |
| 1979-06-30 | vs SEA | 77 | W 8-1 | - | | 27,852 | Moose Haas | John Montague | Moose Haas | John Montague | | 383 | 337 | 46 |
| 1979-07-01 | vs SEA | 78 | W 10-3 | - | | 27,925 | Jim Slaton | Floyd Bannister | Jim Slaton | Floyd Bannister | | 393 | 340 | 53 |
| 1979-07-03 | @ NYA | 79 | W 7-2 | - | | 35,158 | Mike Caldwell | Ken Clay | Mike Caldwell | Ken Clay | | 400 | 342 | 58 |
| 1979-07-04 | @ NYA | 80 | L 3-4 | - | | 20,084 | Bill Travers | Luis Tiant | Luis Tiant | Bill Travers | Ron Davis | 403 | 346 | 57 |
| 1979-07-05 | @ NYA | 81 | W 3-0 | - | | 31,878 | Lary Sorensen | Ron Guidry | Lary Sorensen | Ron Guidry | | 406 | 346 | 60 |
| 1979-07-06 | vs DET | 82 | L 4-7 | - | | 0 | Moose Haas | Jack Morris | Jack Morris | Moose Haas | Aurelio Lopez | 410 | 353 | 57 |
| 1979-07-06 | vs DET | 83 | L 4-5 | - | | 54,630 | Jim Slaton | Milt Wilcox | Milt Wilcox | Jim Slaton | Dave Tobik | 414 | 358 | 56 |
| 1979-07-07 | vs DET | 84 | L 3-6 | - | | 33,265 | Paul Mitchell | Pat Underwood | Pat Underwood | Paul Mitchell | Aurelio Lopez | 417 | 364 | 53 |
| 1979-07-08 | vs DET | 85 | W 5-4 | - | | 0 | Mike Caldwell | Jack Billingham | Mike Caldwell | John Hiller | | 422 | 368 | 54 |
| 1979-07-08 | vs DET | 86 | W 3-1 | - | | 39,141 | Bill Travers | Dan Petry | Bill Travers | Dan Petry | | 425 | 369 | 56 |
| 1979-07-09 | @ TOR | 87 | L 1-7 | - | | 14,240 | Lary Sorensen | Dave Stieb | Dave Stieb | Lary Sorensen | | 426 | 376 | 50 |
| 1979-07-11 | @ TOR | 88 | W 2-1 | - | | 22,523 | Jim Slaton | Phil Huffman | Jim Slaton | Tom Buskey | | 428 | 377 | 51 |
| 1979-07-12 | @ TOR | 89 | W 5-3 | - | | 14,207 | Moose Haas | Tom Underwood | Moose Haas | Tom Underwood | Bob Galasso | 433 | 380 | 53 |
| 1979-07-13 | vs CLE | 90 | W 4-3 | - | | 18,524 | Mike Caldwell | Rick Wise | Bob Galasso | Victor Cruz | | 437 | 383 | 54 |
| 1979-07-14 | vs CLE | 91 | W 10-3 | - | | 33,731 | Bill Travers | David Clyde | Bill Travers | David Clyde | Reggie Cleveland | 447 | 386 | 61 |
| 1979-07-15 | vs CLE | 92 | W 10-4 | - | | 36,531 | Lary Sorensen | Len Barker | Lary Sorensen | Len Barker | | 457 | 390 | 67 |
| 1979-07-19 | vs TOR | 93 | W 3-2 | - | | 21,152 | Bill Travers | Dave Stieb | Bill Castro | Tom Buskey | | 460 | 392 | 68 |
| 1979-07-20 | vs TOR | 94 | W 2-0 | - | | 27,010 | Jim Slaton | Tom Underwood | Jim Slaton | Tom Underwood | | 462 | 392 | 70 |
| 1979-07-21 | @ CLE | 95 | W 5-0 | - | | 12,812 | Moose Haas | Len Barker | Moose Haas | Len Barker | | 467 | 392 | 75 |
| 1979-07-22 | @ CLE | 96 | W 14-5 | - | | 0 | Mike Caldwell | Mike Paxton | Mike Caldwell | Mike Paxton | Reggie Cleveland | 481 | 397 | 84 |
| 1979-07-22 | @ CLE | 97 | W 5-3 | - | | 29,876 | Paul Mitchell | David Clyde | Paul Mitchell | David Clyde | Bill Castro | 486 | 400 | 86 |
| 1979-07-23 | @ CLE | 98 | L 4-5 | - | | 7,191 | Lary Sorensen | Eric Wilkins | Dan Spillner | Lary Sorensen | Sid Monge | 490 | 405 | 85 |
| 1979-07-24 | @ DET | 99 | W 5-4 | - | | 20,630 | Bill Travers | Pat Underwood | Bill Travers | Pat Underwood | Bob Galasso | 495 | 409 | 86 |
| 1979-07-25 | @ DET | 100 | L 2-11 | - | | 17,858 | Jim Slaton | Jack Morris | Jack Morris | Jim Slaton | | 497 | 420 | 77 |
| 1979-07-26 | @ DET | 101 | L 2-5 | - | | 24,079 | Moose Haas | Dan Petry | Dan Petry | Moose Haas | | 499 | 425 | 74 |
| 1979-07-27 | vs NYA | 102 | W 6-5 | - | | 47,928 | Mike Caldwell | Ed Figueroa | Bob McClure | Rich Gossage | | 505 | 430 | 75 |
| 1979-07-28 | vs NYA | 103 | W 9-2 | - | | 51,952 | Lary Sorensen | Luis Tiant | Lary Sorensen | Luis Tiant | | 514 | 432 | 82 |
| 1979-07-29 | vs NYA | 104 | W 5-3 | - | | 49,842 | Bill Travers | Catfish Hunter | Bill Travers | Catfish Hunter | Bob McClure | 519 | 435 | 84 |
| 1979-07-30 | vs BAL | 105 | L 1-2 | - | | 30,160 | Jim Slaton | Steve Stone | Steve Stone | Jim Slaton | Tippy Martinez | 520 | 437 | 83 |
| 1979-07-31 | vs BAL | 106 | L 5-9 | - | | 36,105 | Paul Mitchell | Mike Flanagan | Sammy Stewart | Paul Mitchell | | 525 | 446 | 79 |
| 1979-08-01 | vs BAL | 107 | L 2-5 | - | | 30,383 | Lary Sorensen | Dennis Martinez | Dennis Martinez | Lary Sorensen | | 527 | 451 | 76 |
| 1979-08-02 | vs BOS | 108 | L 1-10 | - | | 27,101 | Bill Travers | Mike Torrez | Mike Torrez | Bill Travers | | 528 | 461 | 67 |
| 1979-08-03 | vs BOS | 109 | W 5-3 | - | | 37,358 | Jim Slaton | Steve Renko | Jim Slaton | Steve Renko | Bill Castro | 533 | 464 | 69 |
| 1979-08-04 | vs BOS | 110 | L 6-8 | - | | 48,664 | Reggie Cleveland | Allen Ripley | Allen Ripley | Reggie Cleveland | Dick Drago | 539 | 472 | 67 |
| 1979-08-05 | vs BOS | 111 | L 2-7 | - | | 0 | Lary Sorensen | Dennis Eckersley | Dennis Eckersley | Lary Sorensen | | 541 | 479 | 62 |
| 1979-08-05 | vs BOS | 112 | L 5-19 | - | | 49,054 | Jerry Augustine | Dick Drago | Win Remmerswaal | Jerry Augustine | | 546 | 498 | 48 |
| 1979-08-07 | @ BAL | 113 | W 7-5 | - | | 39,524 | Mike Caldwell | Scott McGregor | Jerry Augustine | Sammy Stewart | | 553 | 503 | 50 |
| 1979-08-08 | @ BAL | 114 | W 8-4 | - | | 25,260 | Bill Travers | Steve Stone | Bill Travers | Don Stanhouse | | 561 | 507 | 54 |
| 1979-08-09 | @ BAL | 115 | L 2-3 | - | | 23,504 | Paul Mitchell | Mike Flanagan | Mike Flanagan | Jerry Augustine | | 563 | 510 | 53 |
| 1979-08-10 | @ BOS | 116 | L 4-5 | - | | 32,914 | Lary Sorensen | Allen Ripley | Dick Drago | Bob McClure | | 567 | 515 | 52 |
| 1979-08-11 | @ BOS | 117 | W 9-6 | - | | 33,343 | Moose Haas | Mike Torrez | Bob Galasso | Mike Torrez | | 576 | 521 | 55 |
| 1979-08-13 | vs KCA | 118 | W 5-4 | - | | 12,578 | Jim Slaton | Larry Gura | Jim Slaton | Dan Quisenberry | | 581 | 525 | 56 |
| 1979-08-14 | vs KCA | 119 | W 5-2 | - | | 21,657 | Mike Caldwell | Dennis Leonard | Mike Caldwell | Dennis Leonard | Bill Castro | 586 | 527 | 59 |
| 1979-08-15 | vs KCA | 120 | W 6-5 | - | | 17,175 | Bill Travers | Rich Gale | Jerry Augustine | Dan Quisenberry | | 592 | 532 | 60 |
| 1979-08-16 | vs TEX | 121 | W 4-1 | - | | 14,559 | Lary Sorensen | Brian Allard | Lary Sorensen | Brian Allard | | 596 | 533 | 63 |
| 1979-08-17 | vs TEX | 122 | W 5-1 | - | | 24,074 | Moose Haas | Steve Comer | Moose Haas | Steve Comer | | 601 | 534 | 67 |
| 1979-08-18 | vs TEX | 123 | L 3-7 | - | | 49,172 | Jim Slaton | Fergie Jenkins | Fergie Jenkins | Jim Slaton | Jim Kern | 604 | 541 | 63 |
| 1979-08-19 | vs TEX | 124 | W 4-3 | - | | 37,376 | Mike Caldwell | Doc Medich | Mike Caldwell | Sparky Lyle | | 608 | 544 | 64 |
| 1979-08-20 | vs CHA | 125 | W 5-3 | - | | 15,624 | Bill Travers | Ken Kravec | Bill Travers | Ken Kravec | Bob Galasso | 613 | 547 | 66 |
| 1979-08-21 | vs CHA | 126 | W 3-2 | - | | 0 | Lary Sorensen | Mike Proly | Lary Sorensen | Mike Proly | Bill Castro | 616 | 549 | 67 |
| 1979-08-21 | vs CHA | 127 | W 9-5 | - | | 27,954 | Paul Mitchell | Fred Howard | Paul Mitchell | Fred Howard | | 625 | 554 | 71 |
| 1979-08-22 | vs CHA | 128 | L 3-4 | - | | 18,401 | Moose Haas | Ross Baumgarten | Ed Farmer | Moose Haas | | 628 | 558 | 70 |
| 1979-08-24 | @ TEX | 129 | W 9-6 | - | | 23,505 | Jim Slaton | Doc Medich | Bob Galasso | Danny Darwin | | 637 | 564 | 73 |
| 1979-08-25 | @ TEX | 130 | W 5-2 | - | | 16,181 | Mike Caldwell | Brian Allard | Mike Caldwell | Brian Allard | | 642 | 566 | 76 |
| 1979-08-26 | @ TEX | 131 | W 6-2 | - | | 9,076 | Bill Travers | Steve Comer | Bill Travers | Steve Comer | | 648 | 568 | 80 |
| 1979-08-27 | @ KCA | 132 | L 9-10 | - | | 30,758 | Lary Sorensen | Rich Gale | Al Hrabosky | Bob Galasso | | 657 | 578 | 79 |
| 1979-08-28 | @ KCA | 133 | W 11-6 | - | | 26,278 | Moose Haas | Craig Chamberlain | Moose Haas | Craig Chamberlain | | 668 | 584 | 84 |
| 1979-08-29 | @ KCA | 134 | L 8-18 | - | | 22,761 | Jim Slaton | Dennis Leonard | Dennis Leonard | Jim Slaton | | 676 | 602 | 74 |
| 1979-08-30 | @ CHA | 135 | W 4-3 | - | | 14,323 | Mike Caldwell | Mike Proly | Jerry Augustine | Guy Hoffman | | 680 | 605 | 75 |
| 1979-08-31 | @ CHA | 136 | L 1-6 | - | | 12,953 | Bill Travers | Steve Trout | Steve Trout | Bill Travers | | 681 | 611 | 70 |
| 1979-09-01 | @ CHA | 137 | L 3-4 | - | | 14,261 | Lary Sorensen | Rich Wortham | Rich Wortham | Lary Sorensen | | 684 | 615 | 69 |
| 1979-09-02 | @ CHA | 138 | W 7-2 | - | | 19,435 | Moose Haas | Ken Kravec | Moose Haas | Ken Kravec | | 691 | 617 | 74 |
| 1979-09-03 | @ OAK | 139 | W 6-3 | - | | 7,948 | Jim Slaton | Mike Norris | Jim Slaton | Mike Norris | Jerry Augustine | 697 | 620 | 77 |
| 1979-09-05 | @ OAK | 140 | L 1-6 | - | | 1,772 | Mike Caldwell | Matt Keough | Matt Keough | Mike Caldwell | | 698 | 626 | 72 |
| 1979-09-07 | @ CAL | 141 | L 3-6 | - | | 30,685 | Bill Travers | Nolan Ryan | Nolan Ryan | Bill Travers | | 701 | 632 | 69 |
| 1979-09-08 | @ CAL | 142 | L 2-3 | - | | 37,624 | Lary Sorensen | Jim Barr | Jim Barr | Jerry Augustine | John Montague | 703 | 635 | 68 |
| 1979-09-09 | @ CAL | 143 | L 2-5 | - | | 27,341 | Moose Haas | Frank Tanana | Frank Tanana | Moose Haas | John Montague | 705 | 640 | 65 |
| 1979-09-11 | vs OAK | 144 | W 5-0 | - | | 7,527 | Jim Slaton | Matt Keough | Jim Slaton | Matt Keough | | 710 | 640 | 70 |
| 1979-09-12 | vs OAK | 145 | W 7-0 | - | | 7,412 | Mike Caldwell | Mike Morgan | Mike Caldwell | Mike Morgan | | 717 | 640 | 77 |
| 1979-09-13 | vs OAK | 146 | L 3-8 | - | | 6,594 | Bill Travers | Steve McCatty | Steve McCatty | Bill Travers | | 720 | 648 | 72 |
| 1979-09-14 | vs CAL | 147 | L 7-8 | - | | 17,840 | Lary Sorensen | Jim Barr | Dave LaRoche | Bill Castro | Don Aase | 727 | 656 | 71 |
| 1979-09-15 | vs CAL | 148 | W 3-2 | - | | 45,732 | Moose Haas | Nolan Ryan | Moose Haas | Nolan Ryan | | 730 | 658 | 72 |
| 1979-09-16 | vs CAL | 149 | W 2-1 | - | | 19,906 | Jim Slaton | Frank Tanana | Jim Slaton | Frank Tanana | | 732 | 659 | 73 |
| 1979-09-17 | @ SEA | 150 | W 7-6 | - | | 5,636 | Mike Caldwell | Rick Honeycutt | Bill Travers | Rich Hinton | Bob McClure | 739 | 665 | 74 |
| 1979-09-18 | @ SEA | 151 | W 7-6 | - | | 5,205 | Paul Mitchell | Roy Branch | Jerry Augustine | Shane Rawley | Bill Castro | 746 | 671 | 75 |
| 1979-09-19 | @ SEA | 152 | W 12-1 | - | | 5,096 | Lary Sorensen | Floyd Bannister | Lary Sorensen | Floyd Bannister | | 758 | 672 | 86 |
| 1979-09-21 | vs MIN | 153 | L 2-3 | - | | 10,791 | Moose Haas | Jerry Koosman | Jerry Koosman | Moose Haas | Mike Marshall | 760 | 675 | 85 |
| 1979-09-22 | vs MIN | 154 | L 3-6 | - | | 18,263 | Jim Slaton | Roger Erickson | Roger Erickson | Jim Slaton | Mike Marshall | 763 | 681 | 82 |
| 1979-09-23 | vs MIN | 155 | W 8-7 | - | | 12,097 | Mike Caldwell | Dave Goltz | Jerry Augustine | Pete Redfern | | 771 | 688 | 83 |
| 1979-09-25 | vs SEA | 156 | W 7-6 | - | | 6,680 | Lary Sorensen | Floyd Bannister | Jerry Augustine | Shane Rawley | | 778 | 694 | 84 |
| 1979-09-26 | vs SEA | 157 | L 1-8 | - | | 8,116 | Moose Haas | Mike Parrott | Mike Parrott | Moose Haas | | 779 | 702 | 77 |
| 1979-09-27 | vs SEA | 158 | W 7-6 | - | | 12,108 | Jim Slaton | Rob Dressler | Bill Travers | Byron McLaughlin | | 786 | 708 | 78 |
| 1979-09-28 | @ MIN | 159 | W 10-1 | - | | 14,376 | Mike Caldwell | Roger Erickson | Mike Caldwell | Roger Erickson | | 796 | 709 | 87 |
| 1979-09-29 | @ MIN | 160 | W 11-8 | - | | 8,658 | Paul Mitchell | Paul Hartzell | Paul Mitchell | Paul Hartzell | Bob McClure | 807 | 717 | 90 |
| 1979-09-30 | @ MIN | 161 | L 0-5 | - | | 10,277 | Lary Sorensen | Jerry Koosman | Jerry Koosman | Lary Sorensen | | 807 | 722 | 85 |