| 1977-04-09 | vs MIN | 1 | W 7-4 | 1-0 | 2 | 12,562 | Mike Torrez | Dave Goltz | Mike Torrez | Ron Schueler | | 7 | 4 | 3 |
| 1977-04-10 | vs MIN | 2 | W 9-6 | 2-1 | 3 | 0 | Doc Medich | Pete Redfern | Doc Medich | Pete Redfern | Pablo Torrealba | 16 | 10 | 6 |
| 1977-04-10 | vs MIN | 3 | L 1-7 | 2-1 | 3 | 5,494 | Jim Umbarger | Paul Thormodsgard | Paul Thormodsgard | Jim Umbarger | Tom Burgmeier | 17 | 17 | 0 |
| 1977-04-11 | vs CAL | 4 | W 3-2 | 3-1 | 3 | 12,337 | Mike Norris | Nolan Ryan | Pablo Torrealba | Nolan Ryan | | 20 | 19 | 1 |
| 1977-04-12 | vs CAL | 5 | W 6-2 | 4-1 | 3 | 2,184 | Stan Bahnsen | Gary Ross | Stan Bahnsen | Gary Ross | Dave Giusti | 26 | 21 | 5 |
| 1977-04-13 | vs CAL | 6 | W 9-3 | 5-1 | 1 | 3,017 | Rick Langford | Wayne Simpson | Rick Langford | Wayne Simpson | Pablo Torrealba | 35 | 24 | 11 |
| 1977-04-14 | vs CAL | 7 | W 8-7 | 6-1 | 1 | 4,738 | Doc Medich | Frank Tanana | Doug Bair | John Verhoeven | | 43 | 31 | 12 |
| 1977-04-15 | @ MIN | 8 | W 3-2 | 7-1 | 1 | 14,788 | Mike Torrez | Paul Thormodsgard | Mike Torrez | Paul Thormodsgard | Dave Giusti | 46 | 33 | 13 |
| 1977-04-16 | @ MIN | 9 | L 1-3 | 7-2 | 2 | 6,946 | Vida Blue | Geoff Zahn | Geoff Zahn | Vida Blue | | 47 | 36 | 11 |
| 1977-04-17 | @ MIN | 10 | L 2-10 | 7-3 | 2 | 5,921 | Jim Umbarger | Mike Pazik | Mike Pazik | Jim Umbarger | | 49 | 46 | 3 |
| 1977-04-19 | vs MIL | 11 | L 4-5 | 7-4 | 2 | 3,799 | Doc Medich | Jim Slaton | Bill Castro | Dave Giusti | | 53 | 51 | 2 |
| 1977-04-20 | vs MIL | 12 | W 4-2 | 8-4 | 2 | 3,849 | Mike Torrez | Jerry Augustine | Mike Torrez | Jerry Augustine | | 57 | 53 | 4 |
| 1977-04-22 | vs CHA | 13 | L 2-8 | 8-5 | 2 | 5,537 | Vida Blue | Francisco Barrios | Francisco Barrios | Vida Blue | | 59 | 61 | -2 |
| 1977-04-23 | vs CHA | 14 | W 3-2 | 9-5 | 2 | 5,254 | Jim Umbarger | Steve Stone | Jim Umbarger | Steve Stone | Dave Giusti | 62 | 63 | -1 |
| 1977-04-24 | vs CHA | 15 | L 5-12 | 10-6 | 2 | 9,187 | Mike Torrez | Chris Knapp | Chris Knapp | Mike Torrez | Bruce Dal Canton | 67 | 75 | -8 |
| 1977-04-24 | vs CHA | 16 | W 11-4 | 10-6 | 2 | 9,187 | Mike Norris | Bart Johnson | Mike Norris | Bart Johnson | | 78 | 79 | -1 |
| 1977-04-25 | @ CAL | 17 | L 6-11 | 10-7 | 4 | 12,396 | Doc Medich | Nolan Ryan | Nolan Ryan | Doc Medich | Sid Monge | 84 | 90 | -6 |
| 1977-04-26 | @ CAL | 18 | W 7-3 | 11-7 | 4 | 11,506 | Vida Blue | Wayne Simpson | Vida Blue | Dick Drago | | 91 | 93 | -2 |
| 1977-04-27 | @ CAL | 19 | W 7-5 | 12-7 | 2 | 13,475 | Jim Umbarger | Paul Hartzell | Rick Langford | Paul Hartzell | Stan Bahnsen | 98 | 98 | 0 |
| 1977-04-29 | @ BOS | 20 | L 4-7 | 12-8 | 2 | 17,411 | Dock Ellis | Fergie Jenkins | Fergie Jenkins | Dock Ellis | Bill Campbell | 102 | 105 | -3 |
| 1977-04-30 | @ BOS | 21 | L 4-8 | 12-9 | 3 | 22,999 | Mike Norris | Luis Tiant | Luis Tiant | Mike Norris | | 106 | 113 | -7 |
| 1977-05-01 | @ BOS | 22 | L 4-6 | 12-10 | 4 | 22,053 | Vida Blue | Bob Stanley | Bill Campbell | Stan Bahnsen | | 110 | 119 | -9 |
| 1977-05-02 | @ BAL | 23 | W 2-0 | 13-10 | 3 | 4,407 | Rick Langford | Rudy May | Rick Langford | Rudy May | Dave Giusti | 112 | 119 | -7 |
| 1977-05-04 | @ BAL | 24 | L 2-9 | 13-11 | 5 | 3,232 | Dock Ellis | Jim Palmer | Jim Palmer | Dock Ellis | | 114 | 128 | -14 |
| 1977-05-05 | @ NYA | 25 | W 5-2 | 14-11 | 4 | 11,889 | Vida Blue | Catfish Hunter | Vida Blue | Catfish Hunter | | 119 | 130 | -11 |
| 1977-05-06 | @ NYA | 26 | L 1-4 | 14-12 | 5 | 17,780 | Doc Medich | Ed Figueroa | Ed Figueroa | Doc Medich | | 120 | 134 | -14 |
| 1977-05-07 | @ NYA | 27 | L 2-11 | 14-13 | 5 | 19,125 | Rick Langford | Don Gullett | Don Gullett | Rick Langford | | 122 | 145 | -23 |
| 1977-05-08 | @ NYA | 28 | L 5-10 | 14-14 | 5 | 35,542 | Dock Ellis | Mike Torrez | Mike Torrez | Dock Ellis | | 127 | 155 | -28 |
| 1977-05-09 | vs BOS | 29 | W 2-1 | 15-14 | 5 | 17,290 | Vida Blue | Reggie Cleveland | Vida Blue | Reggie Cleveland | | 129 | 156 | -27 |
| 1977-05-11 | vs BOS | 30 | W 3-1 | 16-14 | 4 | 3,183 | Doc Medich | Fergie Jenkins | Doc Medich | Fergie Jenkins | | 132 | 157 | -25 |
| 1977-05-13 | vs BAL | 31 | L 1-5 | 16-15 | 5 | 4,115 | Vida Blue | Rudy May | Rudy May | Vida Blue | | 133 | 162 | -29 |
| 1977-05-14 | vs BAL | 32 | L 0-2 | 16-16 | 5 | 4,216 | Rick Langford | Mike Flanagan | Mike Flanagan | Rick Langford | | 133 | 164 | -31 |
| 1977-05-15 | vs BAL | 33 | L 2-3 | 16-17 | 5 | 5,419 | Stan Bahnsen | Ross Grimsley | Ross Grimsley | Stan Bahnsen | Dennis Martinez | 135 | 167 | -32 |
| 1977-05-16 | vs NYA | 34 | W 8-4 | 17-17 | 5 | 32,409 | Doc Medich | Ken Holtzman | Bob Lacey | Ken Holtzman | | 143 | 171 | -28 |
| 1977-05-17 | vs NYA | 35 | L 2-5 | 17-18 | 5 | 7,813 | Vida Blue | Ron Guidry | Sparky Lyle | Dave Giusti | | 145 | 176 | -31 |
| 1977-05-19 | vs SEA | 36 | L 0-3 | 17-19 | 5 | 2,179 | Rick Langford | Dave Pagan | Dave Pagan | Rick Langford | | 145 | 179 | -34 |
| 1977-05-20 | vs SEA | 37 | W 14-5 | 18-19 | 5 | 2,660 | Doc Medich | Rick Jones | Doc Medich | Rick Jones | | 159 | 184 | -25 |
| 1977-05-21 | vs SEA | 38 | L 6-7 | 18-20 | 6 | 3,230 | Dock Ellis | Glenn Abbott | Mike Kekich | Bob Lacey | | 165 | 191 | -26 |
| 1977-05-22 | vs SEA | 39 | L 2-6 | 18-21 | 6 | 3,138 | Vida Blue | Dick Pole | Dick Pole | Vida Blue | Enrique Romo | 167 | 197 | -30 |
| 1977-05-23 | @ TOR | 40 | W 3-0 | 19-21 | 4 | 27,705 | Rick Langford | Pete Vuckovich | Rick Langford | Pete Vuckovich | | 170 | 197 | -27 |
| 1977-05-25 | @ TOR | 41 | W 6-5 | 20-21 | 5 | 36,097 | Jim Umbarger | Jerry Garvin | Dave Giusti | Jerry Garvin | | 176 | 202 | -26 |
| 1977-05-27 | @ CLE | 42 | L 1-3 | 20-22 | 5 | 16,557 | Vida Blue | Wayne Garland | Wayne Garland | Vida Blue | | 177 | 205 | -28 |
| 1977-05-28 | @ CLE | 43 | W 5-1 | 21-22 | 5 | 15,482 | Doc Medich | Jim Bibby | Doc Medich | Jim Bibby | Bob Lacey | 182 | 206 | -24 |
| 1977-05-29 | @ CLE | 44 | L 4-5 | 21-23 | 5 | 25,476 | Rick Langford | Pat Dobson | Sid Monge | Bob Lacey | | 186 | 211 | -25 |
| 1977-05-30 | @ DET | 45 | W 6-3 | 22-23 | 5 | 12,026 | Dock Ellis | Dave Roberts | Dock Ellis | Dave Roberts | Joe Coleman | 192 | 214 | -22 |
| 1977-05-31 | @ DET | 46 | L 2-5 | 22-24 | 5 | 7,067 | Vida Blue | John Hiller | John Hiller | Vida Blue | Steve Foucault | 194 | 219 | -25 |
| 1977-06-01 | @ SEA | 47 | W 6-3 | 23-24 | 4 | 14,350 | Doc Medich | Glenn Abbott | Doc Medich | Glenn Abbott | Joe Coleman | 200 | 222 | -22 |
| 1977-06-02 | @ SEA | 48 | W 1-0 | 24-24 | 4 | 10,712 | Mike Norris | Dick Pole | Mike Norris | Dick Pole | | 201 | 222 | -21 |
| 1977-06-03 | vs TOR | 49 | W 3-2 | 25-24 | 5 | 3,030 | Rick Langford | Jesse Jefferson | Bob Lacey | Jesse Jefferson | | 204 | 224 | -20 |
| 1977-06-04 | vs TOR | 50 | L 2-4 | 25-25 | 3 | 4,525 | Dock Ellis | Dave Lemanczyk | Dave Lemanczyk | Dock Ellis | Pete Vuckovich | 206 | 228 | -22 |
| 1977-06-05 | vs TOR | 51 | L 3-7 | 25-26 | 5 | 4,580 | Vida Blue | Jerry Garvin | Jerry Garvin | Vida Blue | Jerry Johnson | 209 | 235 | -26 |
| 1977-06-06 | vs CLE | 52 | L 1-3 | 25-27 | 5 | 13,264 | Doc Medich | Pat Dobson | Pat Dobson | Bob Lacey | Jim Kern | 210 | 238 | -28 |
| 1977-06-08 | vs CLE | 53 | W 3-2 | 26-27 | 5 | 7,828 | Mike Norris | Dennis Eckersley | Pablo Torrealba | Dennis Eckersley | Bob Lacey | 213 | 240 | -27 |
| 1977-06-10 | vs DET | 54 | L 4-6 | 26-28 | 6 | 3,799 | Rick Langford | Fernando Arroyo | Fernando Arroyo | Rick Langford | Steve Foucault | 217 | 246 | -29 |
| 1977-06-11 | vs DET | 55 | L 1-5 | 26-29 | 6 | 18,164 | Dock Ellis | Mark Fidrych | Mark Fidrych | Dock Ellis | | 218 | 251 | -33 |
| 1977-06-12 | vs DET | 56 | W 7-1 | 27-29 | 6 | 5,120 | Vida Blue | Dave Rozema | Vida Blue | Dave Rozema | | 225 | 252 | -27 |
| 1977-06-14 | @ SEA | 57 | W 6-3 | 28-29 | 5 | 13,764 | Doc Medich | Rick Jones | Pablo Torrealba | Tom House | Bob Lacey | 231 | 255 | -24 |
| 1977-06-15 | @ SEA | 58 | L 5-6 | 28-30 | 6 | 14,248 | Mike Norris | John Montague | Mike Kekich | Pablo Torrealba | | 236 | 261 | -25 |
| 1977-06-16 | @ SEA | 59 | L 1-3 | 28-31 | 6 | 11,097 | Rick Langford | Glenn Abbott | Glenn Abbott | Rick Langford | | 237 | 264 | -27 |
| 1977-06-18 | @ CHA | 60 | L 0-2 | 28-32 | 6 | 23,483 | Vida Blue | Ken Kravec | Ken Kravec | Vida Blue | Lerrin LaGrow | 237 | 266 | -29 |
| 1977-06-19 | @ CHA | 61 | L 1-2 | 28-34 | 6 | 24,161 | Mike Norris | Wilbur Wood | Wilbur Wood | Mike Norris | Lerrin LaGrow | 238 | 268 | -30 |
| 1977-06-19 | @ CHA | 62 | L 1-5 | 28-34 | 6 | 24,161 | Doc Medich | Francisco Barrios | Francisco Barrios | Doc Medich | | 239 | 273 | -34 |
| 1977-06-20 | @ CHA | 63 | W 7-1 | 29-34 | 6 | 13,933 | Rick Langford | Chris Knapp | Rick Langford | Chris Knapp | Bob Lacey | 246 | 274 | -28 |
| 1977-06-21 | @ MIL | 64 | L 1-12 | 29-35 | 6 | 9,619 | Paul Mitchell | Jim Slaton | Jim Slaton | Paul Mitchell | | 247 | 286 | -39 |
| 1977-06-22 | @ MIL | 65 | L 1-5 | 29-36 | 6 | 16,759 | Vida Blue | Jerry Augustine | Jerry Augustine | Vida Blue | | 248 | 291 | -43 |
| 1977-06-24 | vs KCA | 66 | L 0-3 | 29-37 | 6 | 4,733 | Doc Medich | Dennis Leonard | Dennis Leonard | Doc Medich | | 248 | 294 | -46 |
| 1977-06-25 | vs KCA | 67 | L 4-6 | 29-38 | 7 | 12,667 | Mike Norris | Jim Colborn | Jim Colborn | Mike Norris | Mark Littell | 252 | 300 | -48 |
| 1977-06-26 | vs KCA | 68 | W 7-3 | 30-39 | 6 | 0 | Vida Blue | Paul Splittorff | Vida Blue | Paul Splittorff | Dave Giusti | 259 | 303 | -44 |
| 1977-06-26 | vs KCA | 69 | L 3-9 | 30-39 | 6 | 9,404 | Rick Langford | Marty Pattin | Marty Pattin | Rick Langford | Larry Gura | 262 | 312 | -50 |
| 1977-06-27 | vs TEX | 70 | L 2-5 | 30-40 | 6 | 13,024 | Paul Mitchell | Mike Marshall | Mike Marshall | Paul Mitchell | Paul Lindblad | 264 | 317 | -53 |
| 1977-06-28 | vs TEX | 71 | W 6-5 | 31-40 | 6 | 5,761 | Doc Medich | Roger Moret | Dave Giusti | Adrian Devine | | 270 | 322 | -52 |
| 1977-06-29 | vs TEX | 72 | L 0-4 | 32-41 | 6 | 0 | Mike Norris | Gaylord Perry | Gaylord Perry | Mike Norris | | 270 | 326 | -56 |
| 1977-06-29 | vs TEX | 73 | W 4-1 | 32-41 | 6 | 17,370 | Rick Langford | Dock Ellis | Rick Langford | Dock Ellis | | 274 | 327 | -53 |
| 1977-07-01 | @ CAL | 74 | W 2-0 | 33-41 | 6 | 13,496 | Vida Blue | Ken Brett | Vida Blue | Ken Brett | | 276 | 327 | -51 |
| 1977-07-02 | @ CAL | 75 | W 9-4 | 34-41 | 6 | 15,057 | Doc Medich | Gary Ross | Bob Lacey | Dyar Miller | | 285 | 331 | -46 |
| 1977-07-03 | @ CAL | 76 | L 4-6 | 34-42 | 6 | 14,352 | Mike Norris | Frank Tanana | Frank Tanana | Mike Norris | | 289 | 337 | -48 |
| 1977-07-04 | @ CAL | 77 | L 2-4 | 34-43 | 6 | 41,303 | Rick Langford | Nolan Ryan | Nolan Ryan | Rick Langford | | 291 | 341 | -50 |
| 1977-07-05 | @ CAL | 78 | L 0-6 | 34-44 | 6 | 12,957 | Vida Blue | Wayne Simpson | Wayne Simpson | Vida Blue | Dyar Miller | 291 | 347 | -56 |
| 1977-07-06 | @ TEX | 79 | L 3-4 | 34-45 | 6 | 7,729 | Doc Medich | Doyle Alexander | Doyle Alexander | Bob Lacey | Adrian Devine | 294 | 351 | -57 |
| 1977-07-07 | @ TEX | 80 | L 3-8 | 34-46 | 6 | 11,346 | Mike Norris | Len Barker | Roger Moret | Mike Norris | | 297 | 359 | -62 |
| 1977-07-08 | @ KCA | 81 | L 2-6 | 34-47 | 6 | 27,647 | Vida Blue | Dennis Leonard | Dennis Leonard | Vida Blue | | 299 | 365 | -66 |
| 1977-07-09 | @ KCA | 82 | W 7-1 | 35-47 | 6 | 35,175 | Rick Langford | Jim Colborn | Rick Langford | Jim Colborn | | 306 | 366 | -60 |
| 1977-07-10 | @ KCA | 83 | L 4-5 | 35-48 | 6 | 21,677 | Doc Medich | Paul Splittorff | Doug Bird | Dave Giusti | | 310 | 371 | -61 |
| 1977-07-11 | vs SEA | 84 | W 8-1 | 36-48 | 6 | 8,760 | Joe Coleman | Tom House | Joe Coleman | Tom House | Bob Lacey | 318 | 372 | -54 |
| 1977-07-12 | vs SEA | 85 | W 3-2 | 37-48 | 6 | 5,299 | Vida Blue | Gary Wheelock | Vida Blue | Enrique Romo | | 321 | 374 | -53 |
| 1977-07-13 | vs SEA | 86 | L 1-3 | 37-49 | 6 | 4,529 | Rick Langford | Glenn Abbott | Glenn Abbott | Rick Langford | | 322 | 377 | -55 |
| 1977-07-15 | vs MIN | 87 | W 8-7 | 38-49 | 6 | 4,559 | Doc Medich | Geoff Zahn | Dave Giusti | Dave Johnson | | 330 | 384 | -54 |
| 1977-07-16 | vs MIN | 88 | W 8-2 | 39-49 | 6 | 16,596 | Vida Blue | Pete Redfern | Vida Blue | Pete Redfern | | 338 | 386 | -48 |
| 1977-07-17 | vs MIN | 89 | L 1-4 | 39-51 | 6 | 0 | Rick Langford | Paul Thormodsgard | Paul Thormodsgard | Rick Langford | | 339 | 390 | -51 |
| 1977-07-17 | vs MIN | 90 | L 5-9 | 39-51 | 6 | 10,170 | Joe Coleman | Ron Schueler | Geoff Zahn | Joe Coleman | Tom Johnson | 344 | 399 | -55 |
| 1977-07-21 | @ SEA | 91 | L 3-4 | 39-52 | 7 | 17,382 | Rick Langford | Glenn Abbott | Glenn Abbott | Rick Langford | Enrique Romo | 347 | 403 | -56 |
| 1977-07-22 | @ SEA | 92 | W 5-3 | 40-52 | 6 | 13,960 | Vida Blue | Dick Pole | Vida Blue | Dick Pole | Bob Lacey | 352 | 406 | -54 |
| 1977-07-23 | @ SEA | 93 | L 3-10 | 40-53 | 7 | 12,216 | Mike Norris | Gary Wheelock | Gary Wheelock | Mike Norris | | 355 | 416 | -61 |
| 1977-07-24 | @ MIN | 94 | L 3-5 | 40-55 | 7 | 0 | Pablo Torrealba | Geoff Zahn | Geoff Zahn | Bob Lacey | Tom Johnson | 358 | 421 | -63 |
| 1977-07-24 | @ MIN | 95 | L 9-10 | 40-55 | 7 | 30,400 | Joe Coleman | Ron Schueler | Tom Johnson | Doug Bair | | 367 | 431 | -64 |
| 1977-07-25 | @ MIN | 96 | L 1-2 | 40-56 | 7 | 18,550 | Rick Langford | Dave Goltz | Dave Goltz | Rick Langford | | 368 | 433 | -65 |
| 1977-07-26 | vs CAL | 97 | W 2-1 | 41-56 | 7 | 7,757 | Vida Blue | Frank Tanana | Vida Blue | Frank Tanana | | 370 | 434 | -64 |
| 1977-07-27 | vs CAL | 98 | L 3-9 | 41-57 | 7 | 5,501 | Paul Mitchell | Ken Brett | Ken Brett | Paul Mitchell | | 373 | 443 | -70 |
| 1977-07-28 | vs CAL | 99 | W 6-4 | 42-57 | 7 | 6,068 | Joe Coleman | Wayne Simpson | Joe Coleman | Wayne Simpson | Dave Giusti | 379 | 447 | -68 |
| 1977-07-29 | vs NYA | 100 | L 0-4 | 42-58 | 7 | 9,450 | Pablo Torrealba | Ron Guidry | Ron Guidry | Pablo Torrealba | Sparky Lyle | 379 | 451 | -72 |
| 1977-07-30 | vs NYA | 101 | L 3-9 | 42-59 | 7 | 9,573 | Rick Langford | Don Gullett | Don Gullett | Rick Langford | Dick Tidrow | 382 | 460 | -78 |
| 1977-07-31 | vs NYA | 102 | L 2-9 | 42-60 | 7 | 11,052 | Vida Blue | Ed Figueroa | Ed Figueroa | Vida Blue | | 384 | 469 | -85 |
| 1977-08-01 | vs BAL | 103 | L 1-5 | 42-61 | 7 | 8,831 | Joe Coleman | Rudy May | Rudy May | Joe Coleman | | 385 | 474 | -89 |
| 1977-08-03 | vs BAL | 104 | L 6-8 | 42-62 | 7 | 5,103 | Rick Langford | Mike Flanagan | Tippy Martinez | Bob Lacey | | 391 | 482 | -91 |
| 1977-08-04 | vs BOS | 105 | L 1-3 | 42-63 | 7 | 13,326 | Vida Blue | Fergie Jenkins | Fergie Jenkins | Vida Blue | | 392 | 485 | -93 |
| 1977-08-05 | vs BOS | 106 | L 0-1 | 42-64 | 7 | 7,163 | Joe Coleman | Luis Tiant | Luis Tiant | Joe Coleman | | 392 | 486 | -94 |
| 1977-08-06 | vs BOS | 107 | L 1-2 | 42-65 | 7 | 6,331 | Pablo Torrealba | Don Aase | Don Aase | Pablo Torrealba | Bill Campbell | 393 | 488 | -95 |
| 1977-08-07 | vs BOS | 108 | L 2-5 | 42-66 | 7 | 7,586 | Rick Langford | Rick Wise | Rick Wise | Rick Langford | Bill Campbell | 395 | 493 | -98 |
| 1977-08-08 | @ TEX | 109 | L 2-5 | 42-68 | 7 | 0 | Jim Umbarger | Bert Blyleven | Bert Blyleven | Jim Umbarger | | 397 | 498 | -101 |
| 1977-08-08 | @ TEX | 110 | L 0-3 | 42-68 | 7 | 19,909 | Doc Medich | Roger Moret | Roger Moret | Doc Medich | Adrian Devine | 397 | 501 | -104 |
| 1977-08-10 | @ NYA | 111 | L 3-6 | 42-69 | 7 | 16,440 | Vida Blue | Ron Guidry | Ron Guidry | Vida Blue | | 400 | 507 | -107 |
| 1977-08-11 | @ NYA | 112 | L 0-3 | 42-70 | 7 | 16,804 | Pablo Torrealba | Mike Torrez | Mike Torrez | Pablo Torrealba | | 400 | 510 | -110 |
| 1977-08-12 | @ BAL | 113 | L 1-6 | 42-71 | 7 | 31,778 | Vida Blue | Jim Palmer | Jim Palmer | Vida Blue | | 401 | 516 | -115 |
| 1977-08-13 | @ BAL | 114 | W 9-6 | 43-71 | 7 | 16,522 | Rick Langford | Mike Flanagan | Rick Langford | Mike Flanagan | Doug Bair | 410 | 522 | -112 |
| 1977-08-14 | @ BAL | 115 | L 4-5 | 43-72 | 7 | 9,579 | Doc Medich | Ross Grimsley | Ross Grimsley | Doc Medich | Tippy Martinez | 414 | 527 | -113 |
| 1977-08-15 | @ CLE | 116 | L 2-7 | 43-73 | 7 | 7,186 | Jim Umbarger | Rick Waits | Rick Waits | Jim Umbarger | | 416 | 534 | -118 |
| 1977-08-16 | @ CLE | 117 | W 7-3 | 44-73 | 7 | 8,863 | Vida Blue | Dennis Eckersley | Vida Blue | Dennis Eckersley | | 423 | 537 | -114 |
| 1977-08-19 | vs CLE | 118 | L 1-2 | 44-74 | 7 | 2,704 | Joe Coleman | Al Fitzmorris | Al Fitzmorris | Joe Coleman | Jim Kern | 424 | 539 | -115 |
| 1977-08-20 | vs CLE | 119 | L 4-5 | 44-75 | 7 | 5,022 | Vida Blue | Rick Waits | Jim Kern | Doug Bair | | 428 | 544 | -116 |
| 1977-08-21 | vs CLE | 120 | L 1-4 | 44-76 | 7 | 2,702 | Rick Langford | Dennis Eckersley | Dennis Eckersley | Rick Langford | | 429 | 548 | -119 |
| 1977-08-22 | vs TOR | 121 | W 5-2 | 45-76 | 7 | 4,429 | Doc Medich | Dave Lemanczyk | Doc Medich | Dave Lemanczyk | Bob Lacey | 434 | 550 | -116 |
| 1977-08-23 | vs TOR | 122 | L 1-8 | 45-77 | 7 | 3,797 | Jim Umbarger | Jim Clancy | Jim Clancy | Jim Umbarger | | 435 | 558 | -123 |
| 1977-08-24 | vs DET | 123 | W 3-1 | 47-77 | 7 | 0 | Vida Blue | Dave Rozema | Vida Blue | Dave Rozema | | 438 | 559 | -121 |
| 1977-08-24 | vs DET | 124 | W 6-5 | 47-77 | 7 | 7,324 | Joe Coleman | Milt Wilcox | Doug Bair | John Hiller | | 444 | 564 | -120 |
| 1977-08-26 | @ TOR | 125 | W 8-4 | 48-77 | 7 | 22,536 | Rick Langford | Jeff Byrd | Pablo Torrealba | Jeff Byrd | | 452 | 568 | -116 |
| 1977-08-27 | @ TOR | 126 | W 9-8 | 49-77 | 7 | 23,651 | Doc Medich | Dave Lemanczyk | Doc Medich | Dave Lemanczyk | Doug Bair | 461 | 576 | -115 |
| 1977-08-28 | @ TOR | 127 | W 6-2 | 50-77 | 6 | 24,087 | Vida Blue | Jim Clancy | Vida Blue | Jim Clancy | | 467 | 578 | -111 |
| 1977-08-29 | @ BOS | 128 | W 8-7 | 51-77 | 6 | 29,750 | Joe Coleman | Rick Wise | Doug Bair | Bill Campbell | | 475 | 585 | -110 |
| 1977-08-30 | @ BOS | 129 | L 2-7 | 51-78 | 6 | 27,264 | Rick Langford | Luis Tiant | Luis Tiant | Rick Langford | Reggie Cleveland | 477 | 592 | -115 |
| 1977-08-31 | @ MIN | 130 | W 4-3 | 52-78 | 6 | 6,318 | Doc Medich | Paul Thormodsgard | Doc Medich | Paul Thormodsgard | Doug Bair | 481 | 595 | -114 |
| 1977-09-02 | @ DET | 131 | L 4-6 | 52-79 | 6 | 11,500 | Vida Blue | Jim Crawford | Jim Crawford | Vida Blue | John Hiller | 485 | 601 | -116 |
| 1977-09-03 | @ DET | 132 | L 8-10 | 52-80 | 7 | 11,159 | Joe Coleman | Bob Sykes | Ed Glynn | Bob Lacey | Steve Foucault | 493 | 611 | -118 |
| 1977-09-04 | @ DET | 133 | W 7-5 | 53-80 | 7 | 15,906 | Rick Langford | Dave Rozema | Bob Lacey | Dave Rozema | Doug Bair | 500 | 616 | -116 |
| 1977-09-05 | vs CHA | 134 | W 8-7 | 54-81 | 6 | 0 | Doc Medich | Ken Kravec | Doc Medich | Ken Kravec | Doug Bair | 508 | 623 | -115 |
| 1977-09-05 | vs CHA | 135 | L 1-2 | 54-81 | 6 | 12,067 | Pablo Torrealba | Wilbur Wood | Wilbur Wood | Pablo Torrealba | Lerrin LaGrow | 509 | 625 | -116 |
| 1977-09-06 | vs CHA | 136 | L 2-7 | 54-82 | 6 | 2,986 | Vida Blue | Chris Knapp | Chris Knapp | Vida Blue | Clay Carroll | 511 | 632 | -121 |
| 1977-09-07 | vs CHA | 137 | L 1-5 | 54-83 | 6 | 3,978 | Matt Keough | Steve Renko | Steve Renko | Matt Keough | Dave Hamilton | 512 | 637 | -125 |
| 1977-09-09 | vs MIL | 138 | L 1-3 | 54-84 | 7 | 4,743 | Rick Langford | Moose Haas | Moose Haas | Rick Langford | | 513 | 640 | -127 |
| 1977-09-10 | vs MIL | 139 | W 4-1 | 55-84 | 6 | 1,944 | Pablo Torrealba | Lary Sorensen | Doc Medich | Lary Sorensen | | 517 | 641 | -124 |
| 1977-09-11 | vs MIL | 140 | W 5-3 | 56-84 | 6 | 2,279 | Vida Blue | Bill Travers | Vida Blue | Bill Travers | Doug Bair | 522 | 644 | -122 |
| 1977-09-14 | @ KCA | 141 | L 2-5 | 56-86 | 6 | 0 | Rick Langford | Jim Colborn | Jim Colborn | Rick Langford | Larry Gura | 524 | 649 | -125 |
| 1977-09-14 | @ KCA | 142 | L 0-6 | 56-86 | 6 | 16,791 | Matt Keough | Dennis Leonard | Dennis Leonard | Matt Keough | | 524 | 655 | -131 |
| 1977-09-15 | @ KCA | 143 | L 6-7 | 56-88 | 6 | 0 | Vida Blue | Andy Hassler | Doug Bird | Doug Bair | | 530 | 662 | -132 |
| 1977-09-15 | @ KCA | 144 | L 4-5 | 56-88 | 6 | 15,182 | Pablo Torrealba | Paul Splittorff | Steve Mingori | Doug Bair | | 534 | 667 | -133 |
| 1977-09-16 | @ MIL | 145 | W 8-1 | 57-88 | 6 | 5,238 | Joe Coleman | Moose Haas | Joe Coleman | Moose Haas | | 542 | 668 | -126 |
| 1977-09-17 | @ MIL | 146 | L 1-8 | 57-89 | 6 | 10,718 | Craig Mitchell | Lary Sorensen | Lary Sorensen | Craig Mitchell | | 543 | 676 | -133 |
| 1977-09-18 | @ MIL | 147 | W 3-1 | 58-89 | 6 | 5,891 | Matt Keough | Bill Travers | Matt Keough | Bill Travers | Doug Bair | 546 | 677 | -131 |
| 1977-09-19 | @ CHA | 148 | L 0-8 | 58-90 | 6 | 4,401 | Vida Blue | Ken Kravec | Ken Kravec | Vida Blue | | 546 | 685 | -139 |
| 1977-09-20 | @ CHA | 149 | L 2-8 | 58-91 | 6 | 5,617 | Rick Langford | Steve Stone | Steve Stone | Rick Langford | Dave Hamilton | 548 | 693 | -145 |
| 1977-09-21 | @ CHA | 150 | W 8-6 | 59-91 | 6 | 6,963 | Pablo Torrealba | Chris Knapp | Doug Bair | Clay Carroll | | 556 | 699 | -143 |
| 1977-09-23 | vs TEX | 151 | L 5-6 | 59-92 | 6 | 1,798 | Matt Keough | Gaylord Perry | Gaylord Perry | Doug Bair | | 561 | 705 | -144 |
| 1977-09-24 | vs TEX | 152 | L 1-3 | 59-93 | 6 | 2,036 | Vida Blue | Doyle Alexander | Doyle Alexander | Vida Blue | | 562 | 708 | -146 |
| 1977-09-25 | vs TEX | 153 | L 4-5 | 59-95 | 7 | 0 | Pablo Torrealba | Roger Moret | Len Barker | Bob Lacey | | 566 | 713 | -147 |
| 1977-09-25 | vs TEX | 154 | L 6-8 | 59-95 | 7 | 2,479 | Rick Langford | Dock Ellis | Dock Ellis | Rick Langford | Adrian Devine | 572 | 721 | -149 |
| 1977-09-26 | vs KCA | 155 | W 7-1 | 60-95 | 7 | 3,909 | Joe Coleman | Jim Colborn | Joe Coleman | Jim Colborn | | 579 | 722 | -143 |
| 1977-09-27 | vs KCA | 156 | W 4-2 | 62-95 | 6 | 0 | Matt Keough | Andy Hassler | Bob Lacey | Randy McGilberry | | 583 | 724 | -141 |
| 1977-09-27 | vs KCA | 157 | W 3-2 | 62-95 | 6 | 3,792 | Steve McCatty | Dennis Leonard | Steve Dunning | Dennis Leonard | Doug Bair | 586 | 726 | -140 |
| 1977-09-28 | vs KCA | 158 | W 6-5 | 63-95 | 6 | 3,056 | Vida Blue | Mark Littell | Bob Lacey | Gary Lance | | 592 | 731 | -139 |
| 1977-09-30 | @ TEX | 159 | L 1-4 | 63-96 | 6 | 7,471 | Pablo Torrealba | Dock Ellis | Dock Ellis | Pablo Torrealba | | 593 | 735 | -142 |
| 1977-10-01 | @ TEX | 160 | L 5-6 | 63-97 | 6 | 10,768 | Steve McCatty | Jim Umbarger | Adrian Devine | Doug Bair | | 598 | 741 | -143 |
| 1977-10-02 | @ TEX | 161 | L 7-8 | 63-98 | 7 | 5,779 | Matt Keough | John Poloni | John Poloni | Matt Keough | Roger Moret | 605 | 749 | -144 |