| 1976-04-09 | @ CHA | 1 | L 0-4 | 0-1 | 4 | 40,318 | Paul Splittorff | Wilbur Wood | Wilbur Wood | Paul Splittorff | | 0 | 4 | -4 |
| 1976-04-13 | vs CAL | 2 | W 7-4 | 1-1 | 4 | 25,516 | Al Fitzmorris | Andy Hassler | Al Fitzmorris | Andy Hassler | Marty Pattin | 7 | 8 | -1 |
| 1976-04-14 | vs CAL | 3 | L 6-7 | 1-2 | 5 | 9,043 | Dennis Leonard | Frank Tanana | Sid Monge | Marty Pattin | Jim Brewer | 13 | 15 | -2 |
| 1976-04-15 | vs CAL | 4 | L 1-5 | 1-3 | 6 | 7,657 | Paul Splittorff | Nolan Ryan | Nolan Ryan | Paul Splittorff | | 14 | 20 | -6 |
| 1976-04-16 | vs CLE | 5 | W 5-3 | 2-3 | 5 | 12,219 | Doug Bird | Fritz Peterson | Steve Mingori | Fritz Peterson | Marty Pattin | 19 | 23 | -4 |
| 1976-04-17 | vs CLE | 6 | W 5-3 | 3-3 | 3 | 9,799 | Al Fitzmorris | Dennis Eckersley | Al Fitzmorris | Dennis Eckersley | | 24 | 26 | -2 |
| 1976-04-18 | vs CLE | 7 | L 0-6 | 3-4 | 4 | 10,466 | Steve Busby | Pat Dobson | Pat Dobson | Steve Busby | | 24 | 32 | -8 |
| 1976-04-20 | @ MIL | 8 | L 4-5 | 3-5 | 5 | 4,902 | Dennis Leonard | Pete Broberg | Pete Broberg | Dennis Leonard | Eduardo Rodriguez | 28 | 37 | -9 |
| 1976-04-22 | @ MIL | 9 | W 2-1 | 4-5 | 4 | 5,196 | Al Fitzmorris | Jim Colborn | Doug Bird | Jim Colborn | | 30 | 38 | -8 |
| 1976-04-23 | @ NYA | 10 | W 3-2 | 5-5 | 2 | 35,116 | Paul Splittorff | Catfish Hunter | Paul Splittorff | Catfish Hunter | Steve Mingori | 33 | 40 | -7 |
| 1976-04-24 | @ NYA | 11 | L 8-9 | 5-6 | 3 | 16,034 | Steve Busby | Ed Figueroa | Sparky Lyle | Marty Pattin | | 41 | 49 | -8 |
| 1976-04-30 | vs NYA | 12 | L 3-5 | 5-7 | 4 | 11,368 | Paul Splittorff | Catfish Hunter | Catfish Hunter | Paul Splittorff | | 44 | 54 | -10 |
| 1976-05-01 | vs NYA | 13 | W 4-1 | 6-7 | 3 | 18,703 | Steve Busby | Ed Figueroa | Steve Busby | Ed Figueroa | | 48 | 55 | -7 |
| 1976-05-02 | vs NYA | 14 | W 2-1 | 7-7 | 3 | 13,424 | Dennis Leonard | Rudy May | Doug Bird | Sparky Lyle | | 50 | 56 | -6 |
| 1976-05-04 | @ BOS | 15 | W 7-5 | 8-7 | 2 | 16,274 | Al Fitzmorris | Bill Lee | Al Fitzmorris | Bill Lee | Doug Bird | 57 | 61 | -4 |
| 1976-05-05 | @ BOS | 16 | W 8-4 | 9-7 | 2 | 17,596 | Paul Splittorff | Fergie Jenkins | Paul Splittorff | Fergie Jenkins | Mark Littell | 65 | 65 | 0 |
| 1976-05-07 | @ BAL | 17 | L 3-4 | 9-8 | 2 | 7,310 | Steve Busby | Mike Cuellar | Wayne Garland | Marty Pattin | | 68 | 69 | -1 |
| 1976-05-08 | @ BAL | 18 | W 6-3 | 10-8 | 2 | 51,195 | Dennis Leonard | Ken Holtzman | Dennis Leonard | Ken Holtzman | Doug Bird | 74 | 72 | 2 |
| 1976-05-09 | @ BAL | 19 | W 7-4 | 11-8 | 2 | 7,590 | Al Fitzmorris | Jim Palmer | Mark Littell | Jim Palmer | | 81 | 76 | 5 |
| 1976-05-10 | vs MIN | 20 | L 4-5 | 11-9 | 2 | 12,526 | Paul Splittorff | Bert Blyleven | Tom Burgmeier | Marty Pattin | Steve Luebber | 85 | 81 | 4 |
| 1976-05-11 | vs MIN | 21 | W 6-3 | 12-9 | 2 | 9,652 | Doug Bird | Jim Hughes | Doug Bird | Steve Luebber | Mark Littell | 91 | 84 | 7 |
| 1976-05-12 | vs MIN | 22 | W 17-5 | 13-9 | 2 | 9,601 | Steve Busby | Joe Decker | Marty Pattin | Joe Decker | | 108 | 89 | 19 |
| 1976-05-13 | vs CHA | 23 | W 13-2 | 14-9 | 2 | 13,657 | Dennis Leonard | Bart Johnson | Dennis Leonard | Bart Johnson | | 121 | 91 | 30 |
| 1976-05-14 | vs CHA | 24 | W 7-1 | 15-9 | 2 | 12,990 | Al Fitzmorris | Pete Vuckovich | Al Fitzmorris | Pete Vuckovich | | 128 | 92 | 36 |
| 1976-05-15 | vs CHA | 25 | W 2-1 | 16-9 | 2 | 14,693 | Paul Splittorff | Rich Gossage | Mark Littell | Rich Gossage | | 130 | 93 | 37 |
| 1976-05-16 | vs CHA | 26 | L 3-4 | 16-10 | 2 | 28,413 | Doug Bird | Terry Forster | Clay Carroll | Doug Bird | Dave Hamilton | 133 | 97 | 36 |
| 1976-05-17 | vs TEX | 27 | W 8-7 | 17-10 | 2 | 18,936 | Dennis Leonard | Bill Singer | Tom Hall | Steve Foucault | | 141 | 104 | 37 |
| 1976-05-18 | vs TEX | 28 | W 3-1 | 18-10 | 1 | 14,116 | Al Fitzmorris | Jim Umbarger | Al Fitzmorris | Jim Umbarger | | 144 | 105 | 39 |
| 1976-05-19 | vs OAK | 29 | W 5-2 | 19-10 | 1 | 22,483 | Paul Splittorff | Mike Torrez | Paul Splittorff | Mike Torrez | Marty Pattin | 149 | 107 | 42 |
| 1976-05-20 | vs OAK | 30 | W 8-4 | 20-10 | 1 | 25,682 | Doug Bird | Paul Mitchell | Doug Bird | Paul Mitchell | Mark Littell | 157 | 111 | 46 |
| 1976-05-21 | @ MIN | 31 | W 5-1 | 21-10 | 1 | 8,619 | Dennis Leonard | Jim Hughes | Dennis Leonard | Jim Hughes | | 162 | 112 | 50 |
| 1976-05-22 | @ MIN | 32 | L 3-5 | 21-11 | 1 | 6,812 | Al Fitzmorris | Dave Goltz | Dave Goltz | Al Fitzmorris | | 165 | 117 | 48 |
| 1976-05-23 | @ MIN | 33 | L 1-3 | 21-12 | 1 | 24,716 | Paul Splittorff | Bert Blyleven | Bert Blyleven | Paul Splittorff | Bill Campbell | 166 | 120 | 46 |
| 1976-05-24 | @ TEX | 34 | W 14-11 | 22-12 | 1 | 12,751 | Doug Bird | Steve Barr | Steve Mingori | Steve Barr | | 180 | 131 | 49 |
| 1976-05-26 | @ TEX | 35 | W 14-2 | 23-13 | 1 | 0 | Dennis Leonard | Gaylord Perry | Dennis Leonard | Gaylord Perry | | 194 | 133 | 61 |
| 1976-05-26 | @ TEX | 36 | L 4-5 | 23-13 | 1 | 16,510 | Al Fitzmorris | Nelson Briles | Steve Foucault | Marty Pattin | | 198 | 138 | 60 |
| 1976-05-27 | @ TEX | 37 | L 4-6 | 23-14 | 1 | 14,755 | Paul Splittorff | Bill Singer | Bill Singer | Paul Splittorff | Joe Hoerner | 202 | 144 | 58 |
| 1976-05-28 | @ CAL | 38 | W 3-0 | 24-14 | 1 | 15,777 | Doug Bird | Nolan Ryan | Doug Bird | Nolan Ryan | | 205 | 144 | 61 |
| 1976-05-29 | @ CAL | 39 | L 2-3 | 24-16 | 1 | 0 | Steve Busby | Sid Monge | Sid Monge | Mark Littell | | 207 | 147 | 60 |
| 1976-05-29 | @ CAL | 40 | L 2-7 | 24-16 | 1 | 28,415 | Al Fitzmorris | Gary Ross | Gary Ross | Al Fitzmorris | | 209 | 154 | 55 |
| 1976-05-30 | @ CAL | 41 | W 3-2 | 25-16 | 1 | 14,193 | Dennis Leonard | Don Kirkwood | Steve Mingori | Dick Drago | | 212 | 156 | 56 |
| 1976-05-31 | @ OAK | 42 | L 1-10 | 25-17 | 1 | 31,842 | Paul Splittorff | Mike Torrez | Mike Torrez | Paul Splittorff | | 213 | 166 | 47 |
| 1976-06-01 | @ OAK | 43 | W 5-2 | 26-17 | 1 | 3,860 | Doug Bird | Stan Bahnsen | Doug Bird | Stan Bahnsen | Marty Pattin | 218 | 168 | 50 |
| 1976-06-02 | @ OAK | 44 | W 4-3 | 27-17 | 1 | 2,628 | Steve Busby | Vida Blue | Mark Littell | Rollie Fingers | Steve Mingori | 222 | 171 | 51 |
| 1976-06-04 | vs MIL | 45 | W 4-3 | 28-17 | 1 | 16,899 | Dennis Leonard | Jim Slaton | Dennis Leonard | Jim Slaton | | 226 | 174 | 52 |
| 1976-06-05 | vs MIL | 46 | W 5-4 | 30-17 | 1 | 0 | Al Fitzmorris | Pete Broberg | Al Fitzmorris | Pete Broberg | Mark Littell | 231 | 178 | 53 |
| 1976-06-05 | vs MIL | 47 | W 7-2 | 30-17 | 1 | 35,817 | Paul Splittorff | Bill Champion | Paul Splittorff | Bill Champion | | 238 | 180 | 58 |
| 1976-06-06 | vs MIL | 48 | L 3-4 | 30-18 | 1 | 15,508 | Doug Bird | Jim Colborn | Jerry Augustine | Marty Pattin | | 241 | 184 | 57 |
| 1976-06-07 | vs DET | 49 | W 10-0 | 31-18 | 1 | 18,392 | Steve Busby | Vern Ruhle | Steve Busby | Vern Ruhle | Mark Littell | 251 | 184 | 67 |
| 1976-06-08 | vs DET | 50 | L 1-3 | 31-19 | 1 | 13,869 | Dennis Leonard | Dave Roberts | Dave Roberts | Dennis Leonard | | 252 | 187 | 65 |
| 1976-06-09 | vs DET | 51 | W 6-3 | 32-19 | 1 | 12,529 | Al Fitzmorris | Ray Bare | Al Fitzmorris | Ray Bare | Steve Mingori | 258 | 190 | 68 |
| 1976-06-10 | vs BAL | 52 | W 7-0 | 33-19 | 1 | 12,210 | Paul Splittorff | Jim Palmer | Paul Splittorff | Jim Palmer | | 265 | 190 | 75 |
| 1976-06-11 | vs BAL | 53 | W 4-0 | 34-19 | 1 | 25,883 | Doug Bird | Mike Cuellar | Doug Bird | Mike Cuellar | Mark Littell | 269 | 190 | 79 |
| 1976-06-12 | vs BAL | 54 | W 7-6 | 35-19 | 1 | 19,693 | Steve Busby | Doyle Alexander | Steve Busby | Doyle Alexander | Marty Pattin | 276 | 196 | 80 |
| 1976-06-13 | vs BAL | 55 | W 8-4 | 36-19 | 1 | 23,751 | Dennis Leonard | Mike Flanagan | Dennis Leonard | Mike Flanagan | | 284 | 200 | 84 |
| 1976-06-14 | @ DET | 56 | W 5-2 | 37-19 | 1 | 16,095 | Al Fitzmorris | Frank MacCormack | Al Fitzmorris | Frank MacCormack | Tom Hall | 289 | 202 | 87 |
| 1976-06-15 | @ DET | 57 | W 21-7 | 38-19 | 1 | 13,834 | Paul Splittorff | Dave Lemanczyk | Paul Splittorff | Dave Lemanczyk | | 310 | 209 | 101 |
| 1976-06-16 | @ DET | 58 | L 3-4 | 38-20 | 1 | 21,659 | Doug Bird | Mark Fidrych | Mark Fidrych | Marty Pattin | | 313 | 213 | 100 |
| 1976-06-18 | @ CLE | 59 | W 5-3 | 39-20 | 1 | 14,170 | Dennis Leonard | Rick Waits | Dennis Leonard | Stan Thomas | | 318 | 216 | 102 |
| 1976-06-19 | @ CLE | 60 | L 0-3 | 39-21 | 1 | 17,389 | Al Fitzmorris | Pat Dobson | Pat Dobson | Al Fitzmorris | Jim Kern | 318 | 219 | 99 |
| 1976-06-20 | @ CLE | 61 | L 8-11 | 39-22 | 1 | 13,295 | Mark Littell | Jackie Brown | Jim Bibby | Mark Littell | Stan Thomas | 326 | 230 | 96 |
| 1976-06-21 | vs CHA | 62 | L 1-2 | 39-23 | 1 | 28,918 | Paul Splittorff | Francisco Barrios | Dave Hamilton | Tom Hall | | 327 | 232 | 95 |
| 1976-06-22 | vs CHA | 63 | L 8-14 | 39-24 | 1 | 18,125 | Steve Busby | Jesse Jefferson | Jesse Jefferson | Steve Busby | | 335 | 246 | 89 |
| 1976-06-23 | @ TEX | 64 | L 5-7 | 39-25 | 1 | 21,336 | Dennis Leonard | Jim Umbarger | Steve Foucault | Dennis Leonard | | 340 | 253 | 87 |
| 1976-06-24 | @ TEX | 65 | L 2-5 | 39-26 | 1 | 14,455 | Al Fitzmorris | Steve Hargan | Steve Hargan | Al Fitzmorris | Joe Hoerner | 342 | 258 | 84 |
| 1976-06-25 | vs CAL | 66 | W 6-3 | 40-26 | 1 | 25,522 | Paul Splittorff | Gary Ross | Paul Splittorff | Gary Ross | Mark Littell | 348 | 261 | 87 |
| 1976-06-26 | vs CAL | 67 | W 3-0 | 41-26 | 1 | 30,125 | Marty Pattin | Nolan Ryan | Marty Pattin | Nolan Ryan | Steve Mingori | 351 | 261 | 90 |
| 1976-06-27 | vs CAL | 68 | W 5-4 | 42-26 | 1 | 37,960 | Steve Busby | Don Kirkwood | Doug Bird | Dick Drago | | 356 | 265 | 91 |
| 1976-06-28 | @ MIN | 69 | L 3-4 | 42-27 | 1 | 6,170 | Dennis Leonard | Bill Singer | Bill Campbell | Mark Littell | | 359 | 269 | 90 |
| 1976-06-29 | @ MIN | 70 | W 1-0 | 43-27 | 1 | 6,201 | Al Fitzmorris | Dave Goltz | Al Fitzmorris | Dave Goltz | | 360 | 269 | 91 |
| 1976-06-30 | @ MIN | 71 | W 4-2 | 44-27 | 1 | 7,471 | Paul Splittorff | Eddie Bane | Paul Splittorff | Eddie Bane | | 364 | 271 | 93 |
| 1976-07-01 | vs OAK | 72 | L 2-5 | 44-28 | 1 | 23,175 | Doug Bird | Paul Mitchell | Rollie Fingers | Marty Pattin | | 366 | 276 | 90 |
| 1976-07-02 | vs OAK | 73 | W 8-5 | 45-28 | 1 | 25,723 | Steve Busby | Vida Blue | Mark Littell | Vida Blue | | 374 | 281 | 93 |
| 1976-07-03 | vs OAK | 74 | W 7-5 | 46-28 | 1 | 33,586 | Dennis Leonard | Dick Bosman | Dennis Leonard | Jim Todd | Steve Mingori | 381 | 286 | 95 |
| 1976-07-04 | vs OAK | 75 | L 0-6 | 46-29 | 1 | 24,647 | Al Fitzmorris | Mike Norris | Mike Norris | Al Fitzmorris | | 381 | 292 | 89 |
| 1976-07-05 | @ NYA | 76 | W 2-1 | 47-29 | 1 | 28,041 | Paul Splittorff | Doyle Alexander | Paul Splittorff | Doyle Alexander | Steve Mingori | 383 | 293 | 90 |
| 1976-07-06 | @ NYA | 77 | W 3-1 | 48-30 | 1 | 0 | Doug Bird | Ed Figueroa | Doug Bird | Ed Figueroa | Steve Mingori | 386 | 294 | 92 |
| 1976-07-06 | @ NYA | 78 | L 4-7 | 48-30 | 1 | 35,370 | Steve Busby | Dick Tidrow | Sparky Lyle | Steve Busby | | 390 | 301 | 89 |
| 1976-07-07 | @ NYA | 79 | W 2-1 | 49-30 | 1 | 23,172 | Andy Hassler | Catfish Hunter | Mark Littell | Catfish Hunter | Steve Mingori | 392 | 302 | 90 |
| 1976-07-09 | @ DET | 80 | W 1-0 | 50-30 | 1 | 51,041 | Dennis Leonard | Mark Fidrych | Dennis Leonard | Mark Fidrych | | 393 | 302 | 91 |
| 1976-07-10 | @ DET | 81 | W 7-1 | 51-30 | 1 | 27,630 | Al Fitzmorris | Dave Roberts | Al Fitzmorris | Dave Roberts | Mark Littell | 400 | 303 | 97 |
| 1976-07-11 | @ DET | 82 | L 5-6 | 51-31 | 1 | 21,764 | Paul Splittorff | Vern Ruhle | John Hiller | Steve Mingori | | 405 | 309 | 96 |
| 1976-07-15 | vs BOS | 83 | W 12-5 | 52-32 | 1 | 0 | Dennis Leonard | Dick Pole | Dennis Leonard | Dick Pole | | 417 | 314 | 103 |
| 1976-07-15 | vs BOS | 84 | L 1-2 | 52-32 | 1 | 24,720 | Doug Bird | Rick Jones | Rick Jones | Doug Bird | Jim Willoughby | 418 | 316 | 102 |
| 1976-07-16 | vs BOS | 85 | W 5-1 | 54-32 | 1 | 0 | Paul Splittorff | Fergie Jenkins | Paul Splittorff | Tom Murphy | | 423 | 317 | 106 |
| 1976-07-16 | vs BOS | 86 | W 2-1 | 54-32 | 1 | 35,600 | Al Fitzmorris | Rick Wise | Al Fitzmorris | Rick Wise | | 425 | 318 | 107 |
| 1976-07-17 | vs BOS | 87 | W 2-1 | 55-32 | 1 | 24,411 | Andy Hassler | Luis Tiant | Mark Littell | Luis Tiant | | 427 | 319 | 108 |
| 1976-07-18 | vs BOS | 88 | W 6-3 | 56-32 | 1 | 29,267 | Marty Pattin | Reggie Cleveland | Marty Pattin | Reggie Cleveland | | 433 | 322 | 111 |
| 1976-07-19 | vs BAL | 89 | L 3-4 | 56-33 | 1 | 39,355 | Dennis Leonard | Jim Palmer | Jim Palmer | Dennis Leonard | Tippy Martinez | 436 | 326 | 110 |
| 1976-07-20 | vs BAL | 90 | L 3-10 | 56-34 | 1 | 16,145 | Doug Bird | Wayne Garland | Wayne Garland | Doug Bird | | 439 | 336 | 103 |
| 1976-07-21 | vs MIL | 91 | L 0-5 | 56-35 | 1 | 15,445 | Al Fitzmorris | Bill Travers | Bill Travers | Al Fitzmorris | Danny Frisella | 439 | 341 | 98 |
| 1976-07-22 | vs MIL | 92 | W 3-1 | 57-35 | 1 | 16,133 | Paul Splittorff | Jim Colborn | Paul Splittorff | Jim Colborn | Mark Littell | 442 | 342 | 100 |
| 1976-07-23 | @ OAK | 93 | L 0-2 | 57-36 | 1 | 9,173 | Marty Pattin | Vida Blue | Vida Blue | Marty Pattin | | 442 | 344 | 98 |
| 1976-07-24 | @ OAK | 94 | W 6-5 | 58-36 | 1 | 42,592 | Dennis Leonard | Dick Bosman | Dennis Leonard | Jim Todd | Steve Mingori | 448 | 349 | 99 |
| 1976-07-25 | @ OAK | 95 | L 2-9 | 58-37 | 1 | 10,237 | Doug Bird | Mike Norris | Glenn Abbott | Doug Bird | | 450 | 358 | 92 |
| 1976-07-26 | @ CAL | 96 | W 4-0 | 59-37 | 1 | 18,753 | Al Fitzmorris | Nolan Ryan | Al Fitzmorris | Nolan Ryan | | 454 | 358 | 96 |
| 1976-07-27 | @ CAL | 97 | L 1-2 | 59-38 | 1 | 8,342 | Paul Splittorff | Frank Tanana | Frank Tanana | Paul Splittorff | | 455 | 360 | 95 |
| 1976-07-28 | @ CAL | 98 | W 3-2 | 60-38 | 1 | 9,947 | Marty Pattin | Paul Hartzell | Larry Gura | Don Kirkwood | | 458 | 362 | 96 |
| 1976-07-30 | vs TEX | 99 | W 2-1 | 61-38 | 1 | 28,411 | Dennis Leonard | Nelson Briles | Dennis Leonard | Nelson Briles | Mark Littell | 460 | 363 | 97 |
| 1976-07-31 | vs TEX | 100 | L 2-4 | 61-39 | 1 | 35,786 | Al Fitzmorris | Bert Blyleven | Bert Blyleven | Al Fitzmorris | | 462 | 367 | 95 |
| 1976-08-01 | vs TEX | 101 | L 4-8 | 61-40 | 1 | 24,732 | Andy Hassler | Gaylord Perry | Gaylord Perry | Andy Hassler | | 466 | 375 | 91 |
| 1976-08-03 | vs MIN | 102 | W 7-1 | 62-40 | 1 | 16,939 | Marty Pattin | Eddie Bane | Marty Pattin | Eddie Bane | | 473 | 376 | 97 |
| 1976-08-04 | vs MIN | 103 | W 4-2 | 63-40 | 1 | 15,932 | Al Fitzmorris | Dave Goltz | Al Fitzmorris | Dave Goltz | Mark Littell | 477 | 378 | 99 |
| 1976-08-05 | vs MIN | 104 | W 6-4 | 64-40 | 1 | 14,544 | Dennis Leonard | Bill Singer | Dennis Leonard | Bill Singer | Steve Mingori | 483 | 382 | 101 |
| 1976-08-06 | @ CHA | 105 | W 9-2 | 66-40 | 1 | 0 | Andy Hassler | Bart Johnson | Andy Hassler | Bart Johnson | | 492 | 384 | 108 |
| 1976-08-06 | @ CHA | 106 | W 8-3 | 66-40 | 1 | 13,284 | Doug Bird | Rich Gossage | Doug Bird | Rich Gossage | | 500 | 387 | 113 |
| 1976-08-07 | @ CHA | 107 | L 3-5 | 66-41 | 1 | 30,382 | Larry Gura | Francisco Barrios | Francisco Barrios | Steve Mingori | | 503 | 392 | 111 |
| 1976-08-08 | @ CHA | 108 | L 2-5 | 67-42 | 1 | 0 | Marty Pattin | Terry Forster | Terry Forster | Marty Pattin | Rich Gossage | 505 | 397 | 108 |
| 1976-08-08 | @ CHA | 109 | W 7-1 | 67-42 | 1 | 15,997 | Al Fitzmorris | Jesse Jefferson | Al Fitzmorris | Jesse Jefferson | | 512 | 398 | 114 |
| 1976-08-09 | vs NYA | 110 | W 8-2 | 68-42 | 1 | 40,435 | Dennis Leonard | Ken Holtzman | Dennis Leonard | Ken Holtzman | | 520 | 400 | 120 |
| 1976-08-10 | vs NYA | 111 | L 1-2 | 68-43 | 1 | 25,173 | Andy Hassler | Dock Ellis | Dock Ellis | Steve Mingori | Sparky Lyle | 521 | 402 | 119 |
| 1976-08-11 | vs NYA | 112 | L 3-5 | 68-44 | 1 | 23,394 | Doug Bird | Doyle Alexander | Doyle Alexander | Doug Bird | Sparky Lyle | 524 | 407 | 117 |
| 1976-08-13 | vs DET | 113 | L 2-3 | 68-45 | 1 | 25,215 | Al Fitzmorris | Vern Ruhle | Vern Ruhle | Al Fitzmorris | John Hiller | 526 | 410 | 116 |
| 1976-08-14 | vs DET | 114 | W 15-3 | 69-45 | 1 | 27,333 | Dennis Leonard | Dave Lemanczyk | Dennis Leonard | Dave Lemanczyk | | 541 | 413 | 128 |
| 1976-08-15 | vs DET | 115 | W 7-3 | 70-45 | 1 | 30,720 | Andy Hassler | Dave Roberts | Andy Hassler | Dave Roberts | | 548 | 416 | 132 |
| 1976-08-16 | vs CLE | 116 | W 6-1 | 71-45 | 1 | 18,797 | Marty Pattin | Jackie Brown | Marty Pattin | Jackie Brown | | 554 | 417 | 137 |
| 1976-08-17 | vs CLE | 117 | W 4-3 | 72-45 | 1 | 14,836 | Doug Bird | Pat Dobson | Mark Littell | Dave LaRoche | | 558 | 420 | 138 |
| 1976-08-18 | vs CLE | 118 | L 1-4 | 72-46 | 1 | 15,095 | Al Fitzmorris | Dennis Eckersley | Dennis Eckersley | Al Fitzmorris | Jim Kern | 559 | 424 | 135 |
| 1976-08-19 | @ MIL | 119 | L 4-6 | 72-47 | 1 | 10,553 | Dennis Leonard | Jerry Augustine | Jerry Augustine | Dennis Leonard | Danny Frisella | 563 | 430 | 133 |
| 1976-08-20 | @ MIL | 120 | W 3-0 | 73-47 | 1 | 15,043 | Andy Hassler | Bill Travers | Andy Hassler | Bill Travers | | 566 | 430 | 136 |
| 1976-08-21 | @ MIL | 121 | W 6-2 | 74-47 | 1 | 17,725 | Marty Pattin | Jim Colborn | Marty Pattin | Jim Colborn | Mark Littell | 572 | 432 | 140 |
| 1976-08-22 | @ MIL | 122 | W 7-4 | 75-47 | 1 | 16,596 | Doug Bird | Jim Slaton | Doug Bird | Danny Frisella | Mark Littell | 579 | 436 | 143 |
| 1976-08-23 | @ CLE | 123 | L 3-4 | 75-48 | 1 | 9,581 | Al Fitzmorris | Dennis Eckersley | Dennis Eckersley | Steve Mingori | | 582 | 440 | 142 |
| 1976-08-24 | @ CLE | 124 | L 1-2 | 75-49 | 1 | 6,615 | Dennis Leonard | Rick Waits | Rick Waits | Dennis Leonard | | 583 | 442 | 141 |
| 1976-08-25 | @ CLE | 125 | W 2-1 | 76-49 | 1 | 7,113 | Andy Hassler | Jim Bibby | Andy Hassler | Jim Kern | Mark Littell | 585 | 443 | 142 |
| 1976-08-26 | @ BOS | 126 | W 7-6 | 77-49 | 1 | 24,199 | Marty Pattin | Reggie Cleveland | Tom Bruno | Jim Willoughby | | 592 | 449 | 143 |
| 1976-08-27 | @ BOS | 127 | L 4-9 | 77-50 | 1 | 24,940 | Doug Bird | Fergie Jenkins | Fergie Jenkins | Doug Bird | | 596 | 458 | 138 |
| 1976-08-28 | @ BOS | 128 | W 8-3 | 78-50 | 1 | 27,058 | Al Fitzmorris | Bill Lee | Al Fitzmorris | Bill Lee | Mark Littell | 604 | 461 | 143 |
| 1976-08-29 | @ BOS | 129 | L 6-15 | 78-51 | 1 | 26,747 | Dennis Leonard | Rick Wise | Rick Wise | Dennis Leonard | | 610 | 476 | 134 |
| 1976-08-30 | @ BAL | 130 | L 2-3 | 78-52 | 1 | 6,249 | Andy Hassler | Rudy May | Rudy May | Andy Hassler | | 612 | 479 | 133 |
| 1976-08-31 | @ BAL | 131 | L 3-4 | 78-53 | 1 | 8,661 | Marty Pattin | Jim Palmer | Jim Palmer | Marty Pattin | Dyar Miller | 615 | 483 | 132 |
| 1976-09-01 | @ BAL | 132 | L 1-7 | 78-54 | 1 | 8,007 | Doug Bird | Mike Flanagan | Mike Flanagan | Doug Bird | | 616 | 490 | 126 |
| 1976-09-03 | vs TEX | 133 | L 1-4 | 78-55 | 1 | 17,748 | Al Fitzmorris | Tommy Boggs | Tommy Boggs | Al Fitzmorris | | 617 | 494 | 123 |
| 1976-09-04 | vs TEX | 134 | W 7-0 | 79-55 | 1 | 31,541 | Dennis Leonard | Jim Umbarger | Dennis Leonard | Jim Umbarger | | 624 | 494 | 130 |
| 1976-09-05 | vs TEX | 135 | L 1-3 | 79-56 | 1 | 22,025 | Andy Hassler | Bert Blyleven | Bert Blyleven | Andy Hassler | | 625 | 497 | 128 |
| 1976-09-06 | vs TEX | 136 | L 4-5 | 79-57 | 1 | 27,008 | Doug Bird | Nelson Briles | Steve Hargan | Doug Bird | Joe Hoerner | 629 | 502 | 127 |
| 1976-09-07 | vs CAL | 137 | L 1-2 | 79-58 | 1 | 9,225 | Marty Pattin | Don Kirkwood | Don Kirkwood | Marty Pattin | | 630 | 504 | 126 |
| 1976-09-08 | vs CAL | 138 | L 0-2 | 79-59 | 1 | 11,939 | Al Fitzmorris | Gary Ross | Dick Drago | Al Fitzmorris | | 630 | 506 | 124 |
| 1976-09-09 | vs CAL | 139 | W 6-5 | 80-59 | 1 | 10,897 | Dennis Leonard | Paul Hartzell | Steve Mingori | Mike Overy | | 636 | 511 | 125 |
| 1976-09-10 | @ MIN | 140 | L 3-18 | 80-60 | 1 | 8,912 | Andy Hassler | Jim Hughes | Jim Hughes | Andy Hassler | | 639 | 529 | 110 |
| 1976-09-11 | @ MIN | 141 | W 8-6 | 81-60 | 1 | 8,955 | Doug Bird | Bill Singer | Mark Littell | Bill Campbell | | 647 | 535 | 112 |
| 1976-09-12 | @ MIN | 142 | W 16-6 | 82-60 | 1 | 8,101 | Marty Pattin | Pete Redfern | Marty Pattin | Pete Redfern | | 663 | 541 | 122 |
| 1976-09-13 | @ CHA | 143 | L 3-4 | 82-62 | 1 | 0 | Dennis Leonard | Chris Knapp | Chris Knapp | Dennis Leonard | Dave Hamilton | 666 | 545 | 121 |
| 1976-09-13 | @ CHA | 144 | L 4-5 | 82-62 | 1 | 5,327 | Al Fitzmorris | Ken Brett | Ken Brett | Steve Mingori | | 670 | 550 | 120 |
| 1976-09-14 | @ CHA | 145 | W 2-1 | 83-62 | 1 | 2,762 | Andy Hassler | Larry Monroe | Andy Hassler | Terry Forster | | 672 | 551 | 121 |
| 1976-09-15 | @ CAL | 146 | L 1-2 | 83-63 | 1 | 6,350 | Doug Bird | Nolan Ryan | Nolan Ryan | Doug Bird | | 673 | 553 | 120 |
| 1976-09-16 | @ CAL | 147 | W 2-0 | 84-63 | 1 | 7,440 | Marty Pattin | Frank Tanana | Marty Pattin | Frank Tanana | | 675 | 553 | 122 |
| 1976-09-17 | vs CHA | 148 | W 3-2 | 85-63 | 1 | 15,087 | Dennis Leonard | Rich Gossage | Dennis Leonard | Rich Gossage | | 678 | 555 | 123 |
| 1976-09-18 | vs CHA | 149 | W 6-5 | 86-63 | 1 | 24,955 | Al Fitzmorris | Ken Brett | Larry Gura | Ken Brett | | 684 | 560 | 124 |
| 1976-09-19 | vs CHA | 150 | W 6-5 | 87-63 | 1 | 39,797 | Andy Hassler | Chris Knapp | Steve Mingori | Terry Forster | | 690 | 565 | 125 |
| 1976-09-21 | vs OAK | 151 | W 3-1 | 88-63 | 1 | 28,869 | Doug Bird | Stan Bahnsen | Doug Bird | Stan Bahnsen | Larry Gura | 693 | 566 | 127 |
| 1976-09-22 | vs OAK | 152 | L 1-11 | 88-64 | 1 | 36,064 | Marty Pattin | Vida Blue | Vida Blue | Marty Pattin | | 694 | 577 | 117 |
| 1976-09-23 | vs OAK | 153 | L 1-8 | 88-65 | 1 | 34,077 | Dennis Leonard | Mike Torrez | Mike Torrez | Dennis Leonard | | 695 | 585 | 110 |
| 1976-09-24 | @ TEX | 154 | W 2-1 | 89-65 | 1 | 6,949 | Al Fitzmorris | Jim Umbarger | Larry Gura | Steve Foucault | Mark Littell | 697 | 586 | 111 |
| 1976-09-25 | @ TEX | 155 | L 0-1 | 89-66 | 1 | 9,001 | Andy Hassler | Bert Blyleven | Bert Blyleven | Andy Hassler | | 697 | 587 | 110 |
| 1976-09-26 | @ TEX | 156 | L 1-3 | 89-67 | 1 | 4,650 | Doug Bird | Nelson Briles | Nelson Briles | Doug Bird | Steve Hargan | 698 | 590 | 108 |
| 1976-09-27 | @ OAK | 157 | L 3-8 | 89-68 | 1 | 37,914 | Dennis Leonard | Vida Blue | Vida Blue | Dennis Leonard | | 701 | 598 | 103 |
| 1976-09-28 | @ OAK | 158 | L 0-1 | 89-69 | 1 | 9,464 | Marty Pattin | Mike Torrez | Mike Torrez | Marty Pattin | | 701 | 599 | 102 |
| 1976-09-29 | @ OAK | 159 | W 4-0 | 90-69 | 1 | 19,631 | Larry Gura | Paul Mitchell | Larry Gura | Paul Mitchell | | 705 | 599 | 106 |
| 1976-10-01 | vs MIN | 160 | L 3-4 | 90-70 | 1 | 38,482 | Doug Bird | Dave Goltz | Bill Campbell | Mark Littell | | 708 | 603 | 105 |
| 1976-10-02 | vs MIN | 161 | L 2-3 | 90-71 | 1 | 14,087 | Dennis Leonard | Bill Singer | Bill Singer | Andy Hassler | Bill Campbell | 710 | 606 | 104 |
| 1976-10-03 | vs MIN | 162 | L 3-5 | 90-72 | 1 | 15,665 | Paul Splittorff | Jim Hughes | Jim Hughes | Paul Splittorff | | 713 | 611 | 102 |