| 1975-04-08 | vs NYA | 1 | W 5-3 | 1-0 | 2 | 56,715 | Gaylord Perry | Doc Medich | Gaylord Perry | Doc Medich | | 5 | 3 | 2 |
| 1975-04-11 | @ MIL | 2 | L 2-6 | 1-1 | 4 | 48,160 | Jim Perry | Bill Champion | Bill Champion | Jim Perry | Tom Murphy | 7 | 9 | -2 |
| 1975-04-12 | @ MIL | 3 | L 5-6 | 1-2 | 5 | 11,515 | Fritz Peterson | Jim Slaton | Jim Slaton | Fritz Peterson | Tom Murphy | 12 | 15 | -3 |
| 1975-04-13 | @ MIL | 4 | W 3-1 | 2-2 | 5 | 22,459 | Gaylord Perry | Pete Broberg | Gaylord Perry | Pete Broberg | | 15 | 16 | -1 |
| 1975-04-18 | vs MIL | 5 | L 1-5 | 2-3 | 5 | 8,812 | Gaylord Perry | Pete Broberg | Pete Broberg | Gaylord Perry | Tom Murphy | 16 | 21 | -5 |
| 1975-04-19 | vs MIL | 6 | L 0-3 | 2-4 | 5 | 21,977 | Jim Perry | Bill Champion | Bill Champion | Jim Perry | | 16 | 24 | -8 |
| 1975-04-20 | vs MIL | 7 | W 7-4 | 3-4 | 5 | 9,464 | Fritz Peterson | Jim Slaton | Fritz Peterson | Jim Slaton | Tom Buskey | 23 | 28 | -5 |
| 1975-04-22 | @ DET | 8 | L 2-6 | 3-5 | 6 | 5,692 | Gaylord Perry | Lerrin LaGrow | Lerrin LaGrow | Gaylord Perry | | 25 | 34 | -9 |
| 1975-04-23 | @ DET | 9 | W 4-3 | 4-5 | 5 | 5,470 | Jim Perry | Joe Coleman | Jim Perry | Joe Coleman | Tom Buskey | 29 | 37 | -8 |
| 1975-04-26 | @ BAL | 10 | W 3-0 | 5-6 | 5 | 0 | Gaylord Perry | Ross Grimsley | Gaylord Perry | Ross Grimsley | | 32 | 37 | -5 |
| 1975-04-26 | @ BAL | 11 | L 2-3 | 5-6 | 5 | 18,603 | Dick Bosman | Mike Torrez | Mike Torrez | Dick Bosman | | 34 | 40 | -6 |
| 1975-04-27 | @ BAL | 12 | L 1-6 | 5-7 | 6 | 14,191 | Jim Perry | Jim Palmer | Jim Palmer | Jim Perry | | 35 | 46 | -11 |
| 1975-04-28 | @ NYA | 13 | L 1-6 | 5-8 | 6 | 9,716 | Fritz Peterson | Rudy May | Rudy May | Fritz Peterson | | 36 | 52 | -16 |
| 1975-04-29 | @ NYA | 14 | W 3-1 | 6-8 | 6 | 6,320 | Don Hood | Larry Gura | Don Hood | Larry Gura | | 39 | 53 | -14 |
| 1975-04-30 | @ BOS | 15 | W 8-1 | 7-8 | 4 | 9,307 | Gaylord Perry | Luis Tiant | Gaylord Perry | Luis Tiant | | 47 | 54 | -7 |
| 1975-05-01 | @ BOS | 16 | L 6-7 | 7-9 | 5 | 6,016 | Jim Perry | Bill Lee | Bill Lee | Jim Perry | Diego Segui | 53 | 61 | -8 |
| 1975-05-02 | vs BAL | 17 | W 4-3 | 8-9 | 5 | 11,167 | Dick Bosman | Mike Cuellar | Dennis Eckersley | Dave Johnson | Tom Buskey | 57 | 64 | -7 |
| 1975-05-03 | vs BAL | 18 | W 6-1 | 9-9 | 4 | 17,714 | Fritz Peterson | Ross Grimsley | Fritz Peterson | Ross Grimsley | | 63 | 65 | -2 |
| 1975-05-04 | vs BAL | 19 | L 1-11 | 10-10 | 4 | 0 | Gaylord Perry | Mike Torrez | Mike Torrez | Gaylord Perry | | 64 | 76 | -12 |
| 1975-05-04 | vs BAL | 20 | W 4-3 | 10-10 | 4 | 17,488 | Don Hood | Doyle Alexander | Tom Buskey | Jesse Jefferson | | 68 | 79 | -11 |
| 1975-05-05 | vs BOS | 21 | L 5-7 | 10-11 | 4 | 7,462 | Jim Perry | Luis Tiant | Luis Tiant | Jim Perry | Dick Drago | 73 | 86 | -13 |
| 1975-05-06 | vs BOS | 22 | L 1-4 | 10-12 | 4 | 3,880 | Dick Bosman | Bill Lee | Bill Lee | Dick Bosman | | 74 | 90 | -16 |
| 1975-05-07 | vs BOS | 23 | L 2-4 | 10-13 | 5 | 4,857 | Fritz Peterson | Reggie Cleveland | Reggie Cleveland | Fritz Peterson | Diego Segui | 76 | 94 | -18 |
| 1975-05-09 | vs CHA | 24 | L 0-2 | 10-14 | 5 | 10,422 | Gaylord Perry | Jim Kaat | Jim Kaat | Gaylord Perry | Terry Forster | 76 | 96 | -20 |
| 1975-05-10 | vs CHA | 25 | L 3-8 | 10-15 | 6 | 10,165 | Don Hood | Wilbur Wood | Wilbur Wood | Don Hood | Rich Gossage | 79 | 104 | -25 |
| 1975-05-11 | vs CHA | 26 | W 4-3 | 11-15 | 5 | 19,490 | Jim Kern | Claude Osteen | Tom Buskey | Terry Forster | | 83 | 107 | -24 |
| 1975-05-13 | @ MIN | 27 | W 3-2 | 12-15 | 5 | 4,097 | Fritz Peterson | Vic Albury | Fritz Peterson | Vic Albury | Dennis Eckersley | 86 | 109 | -23 |
| 1975-05-14 | @ MIN | 28 | L 0-3 | 12-16 | 5 | 3,176 | Gaylord Perry | Jim Hughes | Jim Hughes | Gaylord Perry | | 86 | 112 | -26 |
| 1975-05-15 | @ MIN | 29 | L 6-7 | 12-17 | 5 | 5,531 | Don Hood | Bert Blyleven | Tom Burgmeier | Jim Perry | | 92 | 119 | -27 |
| 1975-05-16 | @ CHA | 30 | L 2-3 | 12-18 | 5 | 5,794 | Jim Kern | Claude Osteen | Rich Gossage | Tom Buskey | | 94 | 122 | -28 |
| 1975-05-17 | @ CHA | 31 | L 1-10 | 12-19 | 5 | 8,070 | Fritz Peterson | Jim Kaat | Jim Kaat | Fritz Peterson | | 95 | 132 | -37 |
| 1975-05-18 | @ CHA | 32 | W 7-6 | 13-19 | 5 | 10,033 | Gaylord Perry | Wilbur Wood | Gaylord Perry | Wilbur Wood | Dennis Eckersley | 102 | 138 | -36 |
| 1975-05-19 | vs CAL | 33 | L 5-12 | 13-20 | 6 | 6,400 | Don Hood | Andy Hassler | Dick Lange | Don Hood | | 107 | 150 | -43 |
| 1975-05-21 | vs CAL | 34 | W 3-2 | 14-20 | 6 | 2,919 | Jim Kern | Frank Tanana | Jim Kern | Frank Tanana | Tom Buskey | 110 | 152 | -42 |
| 1975-05-23 | vs OAK | 35 | L 0-3 | 14-21 | 6 | 15,608 | Gaylord Perry | Sonny Siebert | Sonny Siebert | Gaylord Perry | Jim Todd | 110 | 155 | -45 |
| 1975-05-24 | vs OAK | 36 | L 5-10 | 14-22 | 6 | 25,801 | Eric Raich | Vida Blue | Rollie Fingers | Don Hood | | 115 | 165 | -50 |
| 1975-05-25 | vs OAK | 37 | W 6-0 | 15-23 | 6 | 0 | Dennis Eckersley | Jim Perry | Dennis Eckersley | Jim Perry | | 121 | 165 | -44 |
| 1975-05-25 | vs OAK | 38 | L 3-6 | 15-23 | 6 | 48,978 | Jim Kern | Dick Bosman | Dick Bosman | Jim Kern | Jim Todd | 124 | 171 | -47 |
| 1975-05-26 | @ CAL | 39 | W 9-3 | 16-23 | 5 | 30,666 | Fritz Peterson | Frank Tanana | Fritz Peterson | Frank Tanana | | 133 | 174 | -41 |
| 1975-05-27 | @ CAL | 40 | W 6-3 | 17-23 | 5 | 6,885 | Gaylord Perry | Bill Singer | Gaylord Perry | Bill Singer | | 139 | 177 | -38 |
| 1975-05-28 | @ CAL | 41 | W 9-2 | 18-23 | 5 | 11,309 | Eric Raich | Nolan Ryan | Eric Raich | Nolan Ryan | Dave LaRoche | 148 | 179 | -31 |
| 1975-05-30 | @ OAK | 42 | L 2-6 | 18-24 | 5 | 7,554 | Jim Kern | Dick Bosman | Dick Bosman | Jim Kern | | 150 | 185 | -35 |
| 1975-05-31 | @ OAK | 43 | W 4-1 | 19-24 | 5 | 7,754 | Dennis Eckersley | Ken Holtzman | Dennis Eckersley | Ken Holtzman | | 154 | 186 | -32 |
| 1975-06-01 | @ OAK | 44 | L 3-6 | 19-25 | 5 | 7,644 | Gaylord Perry | Sonny Siebert | Sonny Siebert | Gaylord Perry | Rollie Fingers | 157 | 192 | -35 |
| 1975-06-03 | vs KCA | 45 | L 2-5 | 19-26 | 5 | 7,043 | Fritz Peterson | Dennis Leonard | Dennis Leonard | Fritz Peterson | | 159 | 197 | -38 |
| 1975-06-04 | vs KCA | 46 | W 4-0 | 20-26 | 5 | 4,348 | Blue Moon Odom | Steve Busby | Blue Moon Odom | Steve Busby | | 163 | 197 | -34 |
| 1975-06-05 | vs KCA | 47 | W 8-7 | 21-26 | 5 | 4,510 | Jim Kern | Al Fitzmorris | Dave LaRoche | Marty Pattin | | 171 | 204 | -33 |
| 1975-06-06 | vs TEX | 48 | W 7-5 | 22-26 | 5 | 12,308 | Dennis Eckersley | Fergie Jenkins | Dave LaRoche | Fergie Jenkins | | 178 | 209 | -31 |
| 1975-06-07 | vs TEX | 49 | L 4-5 | 22-27 | 5 | 18,800 | Gaylord Perry | Steve Hargan | Stan Thomas | Gaylord Perry | | 182 | 214 | -32 |
| 1975-06-08 | vs TEX | 50 | W 3-2 | 23-28 | 5 | 0 | Eric Raich | Jim Bibby | Eric Raich | Jim Bibby | Dave LaRoche | 185 | 216 | -31 |
| 1975-06-08 | vs TEX | 51 | L 6-7 | 23-28 | 5 | 15,146 | Fritz Peterson | Jackie Brown | Stan Thomas | Tom Buskey | | 191 | 223 | -32 |
| 1975-06-09 | vs MIN | 52 | L 10-11 | 23-29 | 5 | 6,912 | Roric Harrison | Jim Hughes | Vic Albury | Tom Buskey | | 201 | 234 | -33 |
| 1975-06-10 | vs MIN | 53 | L 3-5 | 23-30 | 5 | 6,340 | Dennis Eckersley | Joe Decker | Tom Burgmeier | Dave LaRoche | | 204 | 239 | -35 |
| 1975-06-11 | @ KCA | 54 | L 1-7 | 23-31 | 6 | 10,787 | Gaylord Perry | Dennis Leonard | Dennis Leonard | Gaylord Perry | | 205 | 246 | -41 |
| 1975-06-12 | @ KCA | 55 | L 1-2 | 23-32 | 6 | 10,873 | Eric Raich | Steve Busby | Steve Busby | Eric Raich | | 206 | 248 | -42 |
| 1975-06-13 | @ TEX | 56 | L 1-2 | 23-33 | 6 | 24,347 | Fritz Peterson | Jim Umbarger | Jim Umbarger | Fritz Peterson | Mike Kekich | 207 | 250 | -43 |
| 1975-06-14 | @ TEX | 57 | L 1-2 | 23-34 | 6 | 22,789 | Roric Harrison | Fergie Jenkins | Fergie Jenkins | Roric Harrison | | 208 | 252 | -44 |
| 1975-06-15 | @ TEX | 58 | W 5-1 | 24-34 | 6 | 27,171 | Dennis Eckersley | Gaylord Perry | Dennis Eckersley | Gaylord Perry | | 213 | 253 | -40 |
| 1975-06-16 | vs BAL | 59 | L 3-8 | 24-35 | 6 | 9,371 | Jim Bibby | Jim Palmer | Jim Palmer | Jim Bibby | Grant Jackson | 216 | 261 | -45 |
| 1975-06-17 | vs BAL | 60 | L 3-5 | 24-36 | 6 | 10,019 | Eric Raich | Mike Cuellar | Mike Cuellar | Eric Raich | Doyle Alexander | 219 | 266 | -47 |
| 1975-06-18 | vs BAL | 61 | L 6-13 | 24-37 | 6 | 7,196 | Fritz Peterson | Ross Grimsley | Ross Grimsley | Fritz Peterson | | 225 | 279 | -54 |
| 1975-06-20 | vs MIL | 62 | L 0-6 | 24-38 | 6 | 9,355 | Roric Harrison | Jim Slaton | Jim Slaton | Roric Harrison | | 225 | 285 | -60 |
| 1975-06-21 | vs MIL | 63 | L 9-11 | 24-39 | 6 | 11,417 | Dennis Eckersley | Pete Broberg | Pete Broberg | Dennis Eckersley | Bill Travers | 234 | 296 | -62 |
| 1975-06-22 | vs MIL | 64 | W 3-2 | 25-39 | 6 | 25,229 | Jim Bibby | Jim Colborn | Tom Buskey | Ed Sprague | | 237 | 298 | -61 |
| 1975-06-23 | @ BOS | 65 | W 11-3 | 26-39 | 6 | 19,591 | Eric Raich | Jim Burton | Eric Raich | Jim Burton | | 248 | 301 | -53 |
| 1975-06-24 | @ BOS | 66 | W 8-6 | 27-39 | 5 | 15,411 | Jim Kern | Bill Lee | Tom Buskey | Dick Drago | | 256 | 307 | -51 |
| 1975-06-25 | @ BOS | 67 | W 8-5 | 28-39 | 5 | 20,847 | Roric Harrison | Dick Pole | Roric Harrison | Dick Pole | Tom Buskey | 264 | 312 | -48 |
| 1975-06-26 | @ MIL | 68 | W 9-2 | 29-39 | 5 | 15,145 | Dennis Eckersley | Jim Colborn | Dennis Eckersley | Jim Colborn | | 273 | 314 | -41 |
| 1975-06-27 | @ MIL | 69 | W 6-1 | 30-39 | 5 | 17,422 | Jim Bibby | Ed Sprague | Jim Bibby | Ed Sprague | | 279 | 315 | -36 |
| 1975-06-28 | @ MIL | 70 | L 6-10 | 30-40 | 5 | 23,360 | Eric Raich | Jim Slaton | Rick Austin | Jackie Brown | | 285 | 325 | -40 |
| 1975-06-29 | @ MIL | 71 | L 3-4 | 30-41 | 5 | 24,640 | Don Hood | Pete Broberg | Eduardo Rodriguez | Don Hood | | 288 | 329 | -41 |
| 1975-06-30 | vs DET | 72 | W 4-1 | 32-41 | 5 | 0 | Roric Harrison | Vern Ruhle | Roric Harrison | Vern Ruhle | | 292 | 330 | -38 |
| 1975-06-30 | vs DET | 73 | W 3-2 | 32-41 | 5 | 26,114 | Eric Raich | Lerrin LaGrow | Eric Raich | Lerrin LaGrow | | 295 | 332 | -37 |
| 1975-07-01 | vs DET | 74 | L 2-6 | 32-42 | 5 | 7,539 | Jim Bibby | Mickey Lolich | Mickey Lolich | Jim Bibby | | 297 | 338 | -41 |
| 1975-07-02 | vs NYA | 75 | W 3-2 | 33-42 | 5 | 15,100 | Dennis Eckersley | Larry Gura | Dave LaRoche | Dick Tidrow | | 300 | 340 | -40 |
| 1975-07-03 | vs NYA | 76 | W 3-2 | 34-42 | 5 | 14,189 | Don Hood | Doc Medich | Don Hood | Doc Medich | Dave LaRoche | 303 | 342 | -39 |
| 1975-07-04 | vs BOS | 77 | W 3-2 | 35-42 | 5 | 36,124 | Eric Raich | Luis Tiant | Eric Raich | Luis Tiant | Dave LaRoche | 306 | 344 | -38 |
| 1975-07-05 | vs BOS | 78 | W 12-2 | 36-42 | 5 | 22,361 | Roric Harrison | Steve Barr | Roric Harrison | Steve Barr | | 318 | 346 | -28 |
| 1975-07-06 | vs BOS | 79 | L 3-5 | 37-43 | 5 | 0 | Jim Bibby | Bill Lee | Bill Lee | Jim Bibby | Dick Drago | 321 | 351 | -30 |
| 1975-07-06 | vs BOS | 80 | W 11-10 | 37-43 | 5 | 59,161 | Jackie Brown | Reggie Cleveland | Fred Beene | Reggie Cleveland | Dave LaRoche | 332 | 361 | -29 |
| 1975-07-07 | @ OAK | 81 | L 3-7 | 37-44 | 5 | 27,702 | Dennis Eckersley | Jim Perry | Jim Perry | Dennis Eckersley | | 335 | 368 | -33 |
| 1975-07-08 | @ OAK | 82 | L 5-15 | 37-45 | 5 | 4,041 | Don Hood | Ken Holtzman | Ken Holtzman | Don Hood | | 340 | 383 | -43 |
| 1975-07-09 | @ OAK | 83 | L 1-3 | 37-46 | 5 | 7,673 | Eric Raich | Dick Bosman | Dick Bosman | Eric Raich | Rollie Fingers | 341 | 386 | -45 |
| 1975-07-11 | @ CAL | 84 | W 5-3 | 38-46 | 5 | 9,034 | Roric Harrison | Dick Lange | Roric Harrison | Dick Lange | Dave LaRoche | 346 | 389 | -43 |
| 1975-07-12 | @ CAL | 85 | W 9-1 | 39-46 | 5 | 27,135 | Dennis Eckersley | Nolan Ryan | Dennis Eckersley | Nolan Ryan | | 355 | 390 | -35 |
| 1975-07-13 | @ CAL | 86 | W 8-7 | 40-46 | 5 | 7,493 | Don Hood | Frank Tanana | Jim Bibby | Don Kirkwood | Dave LaRoche | 363 | 397 | -34 |
| 1975-07-17 | vs OAK | 87 | L 3-6 | 40-47 | 5 | 15,085 | Eric Raich | Ken Holtzman | Ken Holtzman | Eric Raich | Paul Lindblad | 366 | 403 | -37 |
| 1975-07-18 | vs OAK | 88 | L 6-7 | 40-48 | 5 | 33,251 | Jim Bibby | Stan Bahnsen | Glenn Abbott | Jim Bibby | Rollie Fingers | 372 | 410 | -38 |
| 1975-07-19 | vs CAL | 89 | L 0-8 | 40-50 | 6 | 0 | Dennis Eckersley | Frank Tanana | Frank Tanana | Dennis Eckersley | | 372 | 418 | -46 |
| 1975-07-19 | vs CAL | 90 | L 2-3 | 40-50 | 6 | 29,682 | Roric Harrison | Bill Singer | Don Kirkwood | Dave LaRoche | Chuck Hockenbery | 374 | 421 | -47 |
| 1975-07-20 | vs CAL | 91 | W 10-4 | 41-50 | 6 | 10,402 | Don Hood | Dick Lange | Don Hood | Dick Lange | | 384 | 425 | -41 |
| 1975-07-21 | vs CAL | 92 | W 2-1 | 42-50 | 5 | 11,012 | Fritz Peterson | Ed Figueroa | Dave LaRoche | Ed Figueroa | | 386 | 426 | -40 |
| 1975-07-22 | @ TEX | 93 | L 0-4 | 42-51 | 5 | 10,106 | Eric Raich | Gaylord Perry | Gaylord Perry | Eric Raich | | 386 | 430 | -44 |
| 1975-07-23 | @ TEX | 94 | L 8-9 | 42-52 | 5 | 15,016 | Roric Harrison | Bill Hands | Steve Foucault | Jackie Brown | | 394 | 439 | -45 |
| 1975-07-25 | @ DET | 95 | L 3-4 | 42-53 | 6 | 25,627 | Don Hood | Ray Bare | Ray Bare | Don Hood | Bob Reynolds | 397 | 443 | -46 |
| 1975-07-26 | @ DET | 96 | W 6-0 | 43-53 | 6 | 0 | Dennis Eckersley | Mickey Lolich | Dennis Eckersley | Mickey Lolich | | 403 | 443 | -40 |
| 1975-07-27 | @ DET | 97 | L 7-8 | 44-54 | 6 | 0 | Eric Raich | Tom Walker | Fernando Arroyo | Dave LaRoche | Bob Reynolds | 410 | 451 | -41 |
| 1975-07-27 | @ DET | 98 | W 7-2 | 44-54 | 6 | 30,850 | Fritz Peterson | Lerrin LaGrow | Fritz Peterson | Lerrin LaGrow | | 417 | 453 | -36 |
| 1975-07-28 | @ BAL | 99 | W 7-5 | 45-54 | 6 | 15,300 | Roric Harrison | Ross Grimsley | Rick Waits | Doyle Alexander | Fred Beene | 424 | 458 | -34 |
| 1975-07-29 | @ BAL | 100 | L 1-7 | 45-55 | 6 | 11,717 | Don Hood | Mike Torrez | Mike Torrez | Don Hood | | 425 | 465 | -40 |
| 1975-07-30 | @ BAL | 101 | W 3-1 | 46-55 | 5 | 13,998 | Dennis Eckersley | Mike Cuellar | Dennis Eckersley | Mike Cuellar | | 428 | 466 | -38 |
| 1975-08-01 | @ NYA | 102 | L 4-5 | 46-56 | 5 | 15,841 | Eric Raich | Catfish Hunter | Catfish Hunter | Eric Raich | Dick Tidrow | 432 | 471 | -39 |
| 1975-08-02 | @ NYA | 103 | L 3-5 | 46-57 | 5 | 43,968 | Fritz Peterson | Pat Dobson | Sparky Lyle | Jim Bibby | | 435 | 476 | -41 |
| 1975-08-03 | @ NYA | 104 | L 1-12 | 47-58 | 5 | 0 | Roric Harrison | Doc Medich | Doc Medich | Roric Harrison | | 436 | 488 | -52 |
| 1975-08-03 | @ NYA | 105 | W 3-2 | 47-58 | 5 | 21,083 | Don Hood | Larry Gura | Don Hood | Dick Tidrow | Dave LaRoche | 439 | 490 | -51 |
| 1975-08-04 | vs DET | 106 | W 6-4 | 48-58 | 5 | 11,240 | Dennis Eckersley | Mickey Lolich | Dennis Eckersley | Mickey Lolich | Jackie Brown | 445 | 494 | -49 |
| 1975-08-05 | vs DET | 107 | W 8-4 | 49-58 | 5 | 5,442 | Eric Raich | Ray Bare | Eric Raich | Ray Bare | Rick Waits | 453 | 498 | -45 |
| 1975-08-06 | vs NYA | 108 | W 5-3 | 50-58 | 5 | 12,343 | Fritz Peterson | Pat Dobson | Fritz Peterson | Pat Dobson | Dave LaRoche | 458 | 501 | -43 |
| 1975-08-07 | vs NYA | 109 | L 3-6 | 50-59 | 5 | 11,124 | Don Hood | Doc Medich | Doc Medich | Don Hood | Sparky Lyle | 461 | 507 | -46 |
| 1975-08-08 | vs KCA | 110 | W 4-3 | 51-59 | 5 | 14,575 | Roric Harrison | Marty Pattin | Roric Harrison | Marty Pattin | Dave LaRoche | 465 | 510 | -45 |
| 1975-08-09 | vs KCA | 111 | L 4-6 | 51-60 | 5 | 25,374 | Dennis Eckersley | Dennis Leonard | Lindy McDaniel | Jim Bibby | Doug Bird | 469 | 516 | -47 |
| 1975-08-10 | vs KCA | 112 | L 1-5 | 51-61 | 5 | 13,111 | Eric Raich | Al Fitzmorris | Al Fitzmorris | Eric Raich | Nelson Briles | 470 | 521 | -51 |
| 1975-08-12 | @ CHA | 113 | W 6-3 | 52-61 | 5 | 8,327 | Fritz Peterson | Wilbur Wood | Fritz Peterson | Wilbur Wood | Dave LaRoche | 476 | 524 | -48 |
| 1975-08-13 | @ CHA | 114 | L 3-4 | 52-62 | 5 | 5,551 | Don Hood | Claude Osteen | Rich Gossage | Jim Bibby | | 479 | 528 | -49 |
| 1975-08-14 | @ CHA | 115 | L 4-6 | 52-63 | 5 | 7,399 | Roric Harrison | Jim Kaat | Jim Kaat | Roric Harrison | Dave Hamilton | 483 | 534 | -51 |
| 1975-08-15 | @ MIN | 116 | L 4-8 | 52-64 | 5 | 11,277 | Dennis Eckersley | Bert Blyleven | Bert Blyleven | Dennis Eckersley | | 487 | 542 | -55 |
| 1975-08-16 | @ MIN | 117 | L 1-9 | 52-65 | 5 | 11,761 | Eric Raich | Jim Hughes | Jim Hughes | Eric Raich | | 488 | 551 | -63 |
| 1975-08-17 | @ MIN | 118 | W 14-5 | 53-65 | 5 | 7,914 | Fritz Peterson | Bill Butler | Fritz Peterson | Bill Butler | | 502 | 556 | -54 |
| 1975-08-18 | vs TEX | 119 | W 4-3 | 55-65 | 4 | 0 | Don Hood | Steve Hargan | Rick Waits | Steve Hargan | | 506 | 559 | -53 |
| 1975-08-18 | vs TEX | 120 | W 4-2 | 55-65 | 4 | 13,410 | Roric Harrison | Fergie Jenkins | Roric Harrison | Fergie Jenkins | Dave LaRoche | 510 | 561 | -51 |
| 1975-08-19 | vs TEX | 121 | L 1-2 | 55-66 | 4 | 8,894 | Dennis Eckersley | Jim Umbarger | Jim Umbarger | Dennis Eckersley | Steve Foucault | 511 | 563 | -52 |
| 1975-08-21 | @ KCA | 122 | W 7-3 | 56-66 | 4 | 11,348 | Jackie Brown | Mark Littell | Jackie Brown | Mark Littell | | 518 | 566 | -48 |
| 1975-08-22 | @ KCA | 123 | W 9-5 | 57-66 | 4 | 13,204 | Fritz Peterson | Paul Splittorff | Fritz Peterson | Paul Splittorff | Jim Bibby | 527 | 571 | -44 |
| 1975-08-23 | @ KCA | 124 | W 7-1 | 58-66 | 4 | 15,396 | Rick Waits | Nelson Briles | Rick Waits | Nelson Briles | | 534 | 572 | -38 |
| 1975-08-24 | @ KCA | 125 | L 2-5 | 58-67 | 4 | 9,475 | Roric Harrison | Al Fitzmorris | Al Fitzmorris | Roric Harrison | Doug Bird | 536 | 577 | -41 |
| 1975-08-25 | vs CHA | 126 | W 5-1 | 59-67 | 4 | 8,171 | Dennis Eckersley | Jim Kaat | Dennis Eckersley | Jim Kaat | | 541 | 578 | -37 |
| 1975-08-27 | vs CHA | 127 | L 0-2 | 60-68 | 4 | 0 | Jim Bibby | Claude Osteen | Claude Osteen | Jim Bibby | Rich Gossage | 541 | 580 | -39 |
| 1975-08-27 | vs CHA | 128 | W 5-0 | 60-68 | 4 | 9,297 | Fritz Peterson | Jesse Jefferson | Fritz Peterson | Jesse Jefferson | | 546 | 580 | -34 |
| 1975-08-29 | vs MIN | 129 | W 9-6 | 61-68 | 4 | 6,520 | Rick Waits | Jim Hughes | Don Hood | Jim Hughes | Bob Reynolds | 555 | 586 | -31 |
| 1975-09-02 | @ BAL | 130 | L 2-3 | 62-69 | 4 | 0 | Dennis Eckersley | Mike Cuellar | Mike Cuellar | Bob Reynolds | | 557 | 589 | -32 |
| 1975-09-02 | @ BAL | 131 | W 2-1 | 62-69 | 4 | 11,018 | Jim Bibby | Doyle Alexander | Jim Bibby | Doyle Alexander | Dave LaRoche | 559 | 590 | -31 |
| 1975-09-03 | @ MIL | 132 | W 11-3 | 63-69 | 4 | 4,177 | Fritz Peterson | Jim Slaton | Fritz Peterson | Jim Slaton | Bob Reynolds | 570 | 593 | -23 |
| 1975-09-04 | @ MIL | 133 | W 10-5 | 64-69 | 4 | 3,810 | Roric Harrison | Lafayette Currence | Roric Harrison | Lafayette Currence | | 580 | 598 | -18 |
| 1975-09-05 | vs DET | 134 | L 2-11 | 64-70 | 4 | 4,108 | Rick Waits | Vern Ruhle | Vern Ruhle | Rick Waits | | 582 | 609 | -27 |
| 1975-09-06 | vs DET | 135 | W 4-2 | 65-70 | 4 | 7,851 | Dennis Eckersley | Dave Lemanczyk | Dennis Eckersley | Dave Lemanczyk | Dave LaRoche | 586 | 611 | -25 |
| 1975-09-07 | vs DET | 136 | W 7-2 | 67-70 | 4 | 0 | Jim Bibby | Joe Coleman | Jim Bibby | Joe Coleman | Tom Buskey | 593 | 613 | -20 |
| 1975-09-07 | vs DET | 137 | W 9-0 | 67-70 | 4 | 17,928 | Fritz Peterson | Lerrin LaGrow | Fritz Peterson | Lerrin LaGrow | | 602 | 613 | -11 |
| 1975-09-08 | vs BOS | 138 | W 4-1 | 68-70 | 4 | 7,438 | Don Hood | Rick Wise | Don Hood | Rick Wise | | 606 | 614 | -8 |
| 1975-09-09 | vs BOS | 139 | W 3-2 | 69-70 | 4 | 7,762 | Rick Waits | Bill Lee | Rick Waits | Bill Lee | | 609 | 616 | -7 |
| 1975-09-10 | vs BAL | 140 | W 7-1 | 70-71 | 4 | 0 | Dennis Eckersley | Mike Cuellar | Dennis Eckersley | Mike Cuellar | Dave LaRoche | 616 | 617 | -1 |
| 1975-09-10 | vs BAL | 141 | L 5-6 | 70-71 | 4 | 10,098 | Jackie Brown | Ross Grimsley | Dyar Miller | Bob Reynolds | Wayne Garland | 621 | 623 | -2 |
| 1975-09-11 | vs BAL | 142 | L 2-10 | 70-72 | 4 | 3,116 | Roric Harrison | Jim Palmer | Jim Palmer | Roric Harrison | | 623 | 633 | -10 |
| 1975-09-13 | @ NYA | 143 | W 7-1 | 71-73 | 4 | 0 | Fritz Peterson | Rudy May | Fritz Peterson | Rudy May | | 630 | 634 | -4 |
| 1975-09-13 | @ NYA | 144 | L 3-4 | 71-73 | 4 | 8,324 | Jim Bibby | Doc Medich | Doc Medich | Jim Bibby | Tippy Martinez | 633 | 638 | -5 |
| 1975-09-14 | @ NYA | 145 | L 2-6 | 71-74 | 4 | 15,125 | Rick Waits | Catfish Hunter | Catfish Hunter | Rick Waits | | 635 | 644 | -9 |
| 1975-09-16 | @ DET | 146 | W 9-2 | 72-74 | 4 | 4,472 | Dennis Eckersley | Fernando Arroyo | Dennis Eckersley | Fernando Arroyo | | 644 | 646 | -2 |
| 1975-09-17 | @ DET | 147 | L 0-4 | 72-75 | 4 | 4,609 | Roric Harrison | Joe Coleman | Joe Coleman | Roric Harrison | | 644 | 650 | -6 |
| 1975-09-18 | @ DET | 148 | W 2-1 | 73-75 | 4 | 4,078 | Jim Bibby | Dave Lemanczyk | Jim Bibby | Dave Lemanczyk | Tom Buskey | 646 | 651 | -5 |
| 1975-09-19 | vs NYA | 149 | W 3-2 | 74-75 | 4 | 9,388 | Fritz Peterson | Catfish Hunter | Fritz Peterson | Catfish Hunter | Dave LaRoche | 649 | 653 | -4 |
| 1975-09-20 | vs NYA | 150 | L 1-4 | 74-76 | 4 | 10,359 | Don Hood | Rudy May | Rudy May | Don Hood | Dave Pagan | 650 | 657 | -7 |
| 1975-09-21 | vs NYA | 151 | W 3-2 | 75-77 | 4 | 0 | Rick Waits | Larry Gura | Rick Waits | Larry Gura | Dave LaRoche | 653 | 659 | -6 |
| 1975-09-21 | vs NYA | 152 | L 5-11 | 75-77 | 4 | 21,149 | Dennis Eckersley | Doc Medich | Doc Medich | Dennis Eckersley | | 658 | 670 | -12 |
| 1975-09-22 | vs MIL | 153 | W 7-6 | 76-77 | 4 | 3,481 | Jim Bibby | Jerry Augustine | Tom Buskey | Tom Murphy | | 665 | 676 | -11 |
| 1975-09-23 | vs MIL | 154 | W 4-3 | 77-77 | 4 | 3,042 | Roric Harrison | Bill Travers | Dave LaRoche | Bill Travers | | 669 | 679 | -10 |
| 1975-09-24 | vs MIL | 155 | L 3-10 | 77-78 | 4 | 4,502 | Fritz Peterson | Jim Colborn | Jim Colborn | Fritz Peterson | Tom Murphy | 672 | 689 | -17 |
| 1975-09-26 | @ BOS | 156 | L 0-4 | 77-80 | 4 | 0 | Dennis Eckersley | Luis Tiant | Luis Tiant | Dennis Eckersley | | 672 | 693 | -21 |
| 1975-09-26 | @ BOS | 157 | L 0-4 | 77-80 | 4 | 22,067 | Don Hood | Reggie Cleveland | Reggie Cleveland | Don Hood | | 672 | 697 | -25 |
| 1975-09-27 | @ BOS | 158 | W 5-2 | 78-80 | 4 | 22,072 | Rick Waits | Rick Wise | Rick Waits | Rick Wise | | 677 | 699 | -22 |
| 1975-09-28 | @ BOS | 159 | W 11-4 | 79-80 | 4 | 25,991 | Fred Beene | Dick Pole | Eric Raich | Dick Pole | Jim Strickland | 688 | 703 | -15 |