| 1975-04-07 | vs KCA | 1 | W 3-2 | 1-0 | 1 | 24,105 | Nolan Ryan | Steve Busby | Nolan Ryan | Steve Mingori | | 3 | 2 | 1 |
| 1975-04-09 | vs KCA | 2 | L 6-7 | 1-1 | 5 | 5,315 | Frank Tanana | Paul Splittorff | Lindy McDaniel | Chuck Dobson | | 9 | 9 | 0 |
| 1975-04-11 | vs CHA | 3 | W 5-0 | 2-1 | 3 | 20,028 | Nolan Ryan | Claude Osteen | Nolan Ryan | Claude Osteen | | 14 | 9 | 5 |
| 1975-04-12 | vs CHA | 4 | W 4-3 | 3-1 | 3 | 6,517 | Andy Hassler | Wilbur Wood | Andy Hassler | Wilbur Wood | | 18 | 12 | 6 |
| 1975-04-13 | vs CHA | 5 | L 5-7 | 3-3 | 3 | 0 | Chuck Dobson | Jim Kaat | Terry Forster | Don Kirkwood | Rich Gossage | 23 | 19 | 4 |
| 1975-04-13 | vs CHA | 6 | L 4-5 | 3-3 | 3 | 14,626 | Bill Singer | Stan Bahnsen | Cecil Upshaw | Bill Singer | Rich Gossage | 27 | 24 | 3 |
| 1975-04-15 | @ MIN | 7 | W 7-3 | 4-3 | 3 | 11,909 | Nolan Ryan | Dave Goltz | Nolan Ryan | Dave Goltz | | 34 | 27 | 7 |
| 1975-04-16 | @ MIN | 8 | L 4-10 | 4-4 | 3 | 2,262 | Andy Hassler | Bert Blyleven | Bert Blyleven | Andy Hassler | | 38 | 37 | 1 |
| 1975-04-19 | @ CHA | 9 | W 6-5 | 5-4 | 3 | 4,591 | Bill Singer | Wilbur Wood | Bill Singer | Wilbur Wood | Don Kirkwood | 44 | 42 | 2 |
| 1975-04-20 | @ CHA | 10 | W 8-4 | 6-4 | 3 | 4,801 | Nolan Ryan | Claude Osteen | Nolan Ryan | Claude Osteen | | 52 | 46 | 6 |
| 1975-04-21 | vs MIN | 11 | L 6-8 | 6-5 | 3 | 16,291 | Andy Hassler | Bill Butler | Tom Burgmeier | Orlando Pena | | 58 | 54 | 4 |
| 1975-04-22 | vs MIN | 12 | L 1-7 | 6-6 | 3 | 5,540 | Chuck Dobson | Vic Albury | Vic Albury | Chuck Dobson | | 59 | 61 | -2 |
| 1975-04-23 | vs TEX | 13 | W 4-1 | 7-6 | 3 | 8,391 | Bill Singer | Clyde Wright | Bill Singer | Clyde Wright | | 63 | 62 | 1 |
| 1975-04-24 | vs TEX | 14 | L 0-5 | 7-7 | 3 | 10,002 | Nolan Ryan | Jackie Brown | Jackie Brown | Nolan Ryan | | 63 | 67 | -4 |
| 1975-04-25 | vs OAK | 15 | W 2-0 | 8-7 | 3 | 20,013 | Andy Hassler | Dave Hamilton | Andy Hassler | Dave Hamilton | | 65 | 67 | -2 |
| 1975-04-26 | vs OAK | 16 | W 1-0 | 9-7 | 3 | 26,188 | Frank Tanana | Ken Holtzman | Frank Tanana | Ken Holtzman | Don Kirkwood | 66 | 67 | -1 |
| 1975-04-27 | vs OAK | 17 | L 1-7 | 10-8 | 3 | 0 | Bill Singer | Vida Blue | Vida Blue | Bill Singer | | 67 | 74 | -7 |
| 1975-04-27 | vs OAK | 18 | W 9-1 | 10-8 | 3 | 26,584 | Ed Figueroa | Blue Moon Odom | Ed Figueroa | Blue Moon Odom | | 76 | 75 | 1 |
| 1975-04-29 | @ KCA | 19 | W 12-1 | 11-8 | 3 | 8,146 | Andy Hassler | Paul Splittorff | Andy Hassler | Paul Splittorff | | 88 | 76 | 12 |
| 1975-04-30 | @ KCA | 20 | W 7-6 | 12-8 | 2 | 7,036 | Frank Tanana | Al Fitzmorris | Mickey Scott | Doug Bird | Bill Singer | 95 | 82 | 13 |
| 1975-05-01 | @ KCA | 21 | L 10-11 | 12-9 | 3 | 6,970 | Ed Figueroa | Nelson Briles | Doug Bird | Orlando Pena | | 105 | 93 | 12 |
| 1975-05-02 | @ TEX | 22 | L 3-4 | 12-10 | 4 | 10,513 | Bill Singer | Steve Hargan | Steve Hargan | Bill Singer | | 108 | 97 | 11 |
| 1975-05-03 | @ TEX | 23 | W 4-2 | 13-10 | 2 | 37,625 | Nolan Ryan | Jackie Brown | Nolan Ryan | Jackie Brown | Dick Lange | 112 | 99 | 13 |
| 1975-05-04 | @ TEX | 24 | L 0-1 | 13-11 | 3 | 10,435 | Andy Hassler | Bill Hands | Bill Hands | Andy Hassler | Steve Foucault | 112 | 100 | 12 |
| 1975-05-05 | @ TEX | 25 | L 3-4 | 13-12 | 3 | 10,300 | Frank Tanana | Fergie Jenkins | Fergie Jenkins | Dick Lange | | 115 | 104 | 11 |
| 1975-05-06 | @ OAK | 26 | L 3-5 | 13-13 | 5 | 5,210 | Ed Figueroa | Ken Holtzman | Paul Lindblad | Don Kirkwood | | 118 | 109 | 9 |
| 1975-05-07 | @ OAK | 27 | L 1-9 | 13-14 | 4 | 3,237 | Bill Singer | Vida Blue | Vida Blue | Bill Singer | | 119 | 118 | 1 |
| 1975-05-08 | @ OAK | 28 | W 5-0 | 14-14 | 4 | 3,598 | Nolan Ryan | Dave Hamilton | Nolan Ryan | Dave Hamilton | | 124 | 118 | 6 |
| 1975-05-09 | vs BOS | 29 | L 1-4 | 14-15 | 5 | 12,411 | Andy Hassler | Rick Wise | Rick Wise | Andy Hassler | | 125 | 122 | 3 |
| 1975-05-10 | vs BOS | 30 | W 2-0 | 15-15 | 3 | 43,112 | Frank Tanana | Luis Tiant | Frank Tanana | Luis Tiant | | 127 | 122 | 5 |
| 1975-05-11 | vs BOS | 31 | L 2-5 | 15-16 | 4 | 10,826 | Bill Singer | Bill Lee | Bill Lee | Bill Singer | | 129 | 127 | 2 |
| 1975-05-13 | vs NYA | 32 | W 5-0 | 16-16 | 4 | 17,598 | Nolan Ryan | Doc Medich | Nolan Ryan | Doc Medich | | 134 | 127 | 7 |
| 1975-05-14 | vs NYA | 33 | L 3-4 | 16-17 | 4 | 16,921 | Andy Hassler | Catfish Hunter | Catfish Hunter | Andy Hassler | | 137 | 131 | 6 |
| 1975-05-16 | @ BAL | 34 | L 0-1 | 17-18 | 4 | 0 | Frank Tanana | Jim Palmer | Jim Palmer | Frank Tanana | | 137 | 132 | 5 |
| 1975-05-16 | @ BAL | 35 | W 3-2 | 17-18 | 4 | 9,233 | Ed Figueroa | Mike Cuellar | Ed Figueroa | Mike Cuellar | | 140 | 134 | 6 |
| 1975-05-17 | @ BAL | 36 | W 6-3 | 18-18 | 5 | 48,042 | Bill Singer | Ross Grimsley | Bill Singer | Wayne Garland | | 146 | 137 | 9 |
| 1975-05-18 | @ BAL | 37 | W 5-1 | 19-18 | 5 | 11,137 | Nolan Ryan | Mike Torrez | Nolan Ryan | Mike Torrez | Don Kirkwood | 151 | 138 | 13 |
| 1975-05-19 | @ CLE | 38 | W 12-5 | 20-18 | 4 | 6,400 | Andy Hassler | Don Hood | Dick Lange | Don Hood | | 163 | 143 | 20 |
| 1975-05-21 | @ CLE | 39 | L 2-3 | 20-19 | 4 | 2,919 | Frank Tanana | Jim Kern | Jim Kern | Frank Tanana | Tom Buskey | 165 | 146 | 19 |
| 1975-05-22 | @ BOS | 40 | W 6-3 | 21-19 | 4 | 9,155 | Bill Singer | Rick Wise | Bill Singer | Rick Wise | | 171 | 149 | 22 |
| 1975-05-23 | @ BOS | 41 | L 1-6 | 21-20 | 5 | 20,587 | Nolan Ryan | Luis Tiant | Luis Tiant | Nolan Ryan | | 172 | 155 | 17 |
| 1975-05-24 | @ BOS | 42 | L 0-6 | 21-21 | 5 | 11,805 | Andy Hassler | Bill Lee | Bill Lee | Andy Hassler | | 172 | 161 | 11 |
| 1975-05-25 | @ BOS | 43 | W 6-1 | 22-21 | 5 | 16,401 | Ed Figueroa | Reggie Cleveland | Ed Figueroa | Reggie Cleveland | | 178 | 162 | 16 |
| 1975-05-26 | vs CLE | 44 | L 3-9 | 22-22 | 5 | 30,666 | Frank Tanana | Fritz Peterson | Fritz Peterson | Frank Tanana | | 181 | 171 | 10 |
| 1975-05-27 | vs CLE | 45 | L 3-6 | 22-23 | 5 | 6,885 | Bill Singer | Gaylord Perry | Gaylord Perry | Bill Singer | | 184 | 177 | 7 |
| 1975-05-28 | vs CLE | 46 | L 2-9 | 22-24 | 5 | 11,309 | Nolan Ryan | Eric Raich | Eric Raich | Nolan Ryan | Dave LaRoche | 186 | 186 | 0 |
| 1975-05-30 | vs BAL | 47 | L 0-5 | 22-25 | 5 | 10,164 | Ed Figueroa | Jim Palmer | Jim Palmer | Ed Figueroa | | 186 | 191 | -5 |
| 1975-05-31 | vs BAL | 48 | L 0-1 | 22-26 | 5 | 15,880 | Bill Singer | Mike Cuellar | Mike Cuellar | Bill Singer | | 186 | 192 | -6 |
| 1975-06-01 | vs BAL | 49 | W 1-0 | 23-26 | 5 | 18,492 | Nolan Ryan | Ross Grimsley | Nolan Ryan | Ross Grimsley | | 187 | 192 | -5 |
| 1975-06-03 | vs DET | 50 | L 5-8 | 23-27 | 5 | 7,412 | Frank Tanana | Joe Coleman | John Hiller | Frank Tanana | | 192 | 200 | -8 |
| 1975-06-04 | vs DET | 51 | W 2-1 | 24-27 | 5 | 8,411 | Ed Figueroa | Ray Bare | Ed Figueroa | Ray Bare | | 194 | 201 | -7 |
| 1975-06-05 | vs DET | 52 | W 8-3 | 25-27 | 5 | 7,357 | Bill Singer | Vern Ruhle | Bill Singer | Vern Ruhle | | 202 | 204 | -2 |
| 1975-06-06 | vs MIL | 53 | W 6-0 | 26-27 | 3 | 29,513 | Nolan Ryan | Jim Slaton | Nolan Ryan | Jim Slaton | | 208 | 204 | 4 |
| 1975-06-07 | vs MIL | 54 | W 5-2 | 27-27 | 3 | 14,212 | Frank Tanana | Bill Castro | Frank Tanana | Bill Castro | | 213 | 206 | 7 |
| 1975-06-08 | vs MIL | 55 | L 3-4 | 27-28 | 3 | 22,230 | Ed Figueroa | Jim Colborn | Jim Colborn | Ed Figueroa | Tom Murphy | 216 | 210 | 6 |
| 1975-06-09 | @ NYA | 56 | W 5-3 | 28-28 | 5 | 22,905 | Bill Singer | Catfish Hunter | Bill Singer | Catfish Hunter | | 221 | 213 | 8 |
| 1975-06-10 | @ NYA | 57 | L 4-6 | 28-29 | 5 | 31,809 | Nolan Ryan | Larry Gura | Larry Gura | Nolan Ryan | Dick Tidrow | 225 | 219 | 6 |
| 1975-06-11 | @ DET | 58 | W 14-7 | 29-30 | 5 | 0 | Frank Tanana | Mickey Lolich | Frank Tanana | Mickey Lolich | | 239 | 226 | 13 |
| 1975-06-11 | @ DET | 59 | L 3-5 | 29-30 | 5 | 22,835 | Andy Hassler | Ray Bare | Ray Bare | Andy Hassler | John Hiller | 242 | 231 | 11 |
| 1975-06-12 | @ DET | 60 | W 7-1 | 30-30 | 4 | 14,490 | Ed Figueroa | Lerrin LaGrow | Ed Figueroa | Lerrin LaGrow | | 249 | 232 | 17 |
| 1975-06-13 | @ MIL | 61 | L 2-10 | 30-31 | 5 | 11,442 | Bill Singer | Jim Colborn | Jim Colborn | Bill Singer | | 251 | 242 | 9 |
| 1975-06-14 | @ MIL | 62 | L 4-6 | 30-32 | 5 | 36,191 | Nolan Ryan | Bill Travers | Bill Travers | Nolan Ryan | Tom Murphy | 255 | 248 | 7 |
| 1975-06-15 | @ MIL | 63 | W 8-7 | 31-33 | 5 | 0 | Frank Tanana | Eduardo Rodriguez | Don Kirkwood | Bill Champion | Mickey Scott | 263 | 255 | 8 |
| 1975-06-15 | @ MIL | 64 | L 2-4 | 31-33 | 5 | 23,597 | Andy Hassler | Jim Slaton | Jim Slaton | Andy Hassler | Tom Murphy | 265 | 259 | 6 |
| 1975-06-17 | @ KCA | 65 | L 2-3 | 31-34 | 5 | 14,029 | Ed Figueroa | Steve Busby | Steve Busby | Ed Figueroa | | 267 | 262 | 5 |
| 1975-06-18 | @ KCA | 66 | L 0-13 | 31-35 | 5 | 16,365 | Nolan Ryan | Marty Pattin | Marty Pattin | Nolan Ryan | | 267 | 275 | -8 |
| 1975-06-20 | vs TEX | 67 | W 12-11 | 32-35 | 5 | 12,101 | Bill Singer | Gaylord Perry | Don Kirkwood | Steve Foucault | | 279 | 286 | -7 |
| 1975-06-21 | vs TEX | 68 | W 4-2 | 33-36 | 5 | 0 | Frank Tanana | Jim Umbarger | Frank Tanana | Jim Umbarger | | 283 | 288 | -5 |
| 1975-06-21 | vs TEX | 69 | L 5-6 | 33-36 | 5 | 19,424 | Andy Hassler | Clyde Wright | Jim Umbarger | Luis Quintana | | 288 | 294 | -6 |
| 1975-06-22 | vs TEX | 70 | W 1-0 | 34-36 | 4 | 8,958 | Ed Figueroa | Fergie Jenkins | Ed Figueroa | Fergie Jenkins | | 289 | 294 | -5 |
| 1975-06-23 | vs TEX | 71 | L 0-1 | 34-37 | 4 | 27,182 | Bill Singer | Steve Hargan | Jim Umbarger | Don Kirkwood | | 289 | 295 | -6 |
| 1975-06-24 | vs KCA | 72 | L 3-5 | 34-38 | 4 | 8,808 | Dick Lange | Dennis Leonard | Doug Bird | Mickey Scott | | 292 | 300 | -8 |
| 1975-06-25 | vs KCA | 73 | L 2-6 | 34-39 | 4 | 7,614 | Frank Tanana | Steve Busby | Steve Busby | Luis Quintana | | 294 | 306 | -12 |
| 1975-06-26 | vs KCA | 74 | L 1-7 | 34-40 | 5 | 6,449 | Ed Figueroa | Marty Pattin | Marty Pattin | Ed Figueroa | | 295 | 313 | -18 |
| 1975-06-27 | vs OAK | 75 | L 4-12 | 34-41 | 6 | 17,473 | Andy Hassler | Vida Blue | Vida Blue | Andy Hassler | | 299 | 325 | -26 |
| 1975-06-28 | vs OAK | 76 | L 4-10 | 34-42 | 6 | 26,465 | Bill Singer | Dick Bosman | Dick Bosman | Bill Singer | Paul Lindblad | 303 | 335 | -32 |
| 1975-06-29 | vs OAK | 77 | L 1-7 | 34-43 | 6 | 16,954 | Nolan Ryan | Ken Holtzman | Ken Holtzman | Nolan Ryan | Rollie Fingers | 304 | 342 | -38 |
| 1975-06-30 | @ MIN | 78 | W 10-3 | 35-43 | 6 | 7,033 | Frank Tanana | Ray Corbin | Frank Tanana | Ray Corbin | | 314 | 345 | -31 |
| 1975-07-01 | @ MIN | 79 | W 4-3 | 36-44 | 6 | 0 | Ed Figueroa | Dave Goltz | Dick Lange | Tom Burgmeier | | 318 | 348 | -30 |
| 1975-07-01 | @ MIN | 80 | L 3-12 | 36-44 | 6 | 7,109 | Andy Hassler | Mark Wiley | Mark Wiley | Andy Hassler | | 321 | 360 | -39 |
| 1975-07-02 | @ MIN | 81 | L 4-9 | 36-45 | 6 | 6,435 | Charlie Hudson | Bert Blyleven | Bert Blyleven | Charlie Hudson | Vic Albury | 325 | 369 | -44 |
| 1975-07-03 | @ MIN | 82 | W 7-6 | 37-45 | 6 | 6,071 | Nolan Ryan | Jim Hughes | Mickey Scott | Bill Butler | Don Kirkwood | 332 | 375 | -43 |
| 1975-07-04 | @ OAK | 83 | L 0-6 | 37-46 | 6 | 40,879 | Frank Tanana | Ken Holtzman | Ken Holtzman | Frank Tanana | | 332 | 381 | -49 |
| 1975-07-05 | @ OAK | 84 | W 2-0 | 38-46 | 6 | 30,442 | Ed Figueroa | Stan Bahnsen | Ed Figueroa | Stan Bahnsen | | 334 | 381 | -47 |
| 1975-07-06 | @ OAK | 85 | W 2-0 | 39-46 | 5 | 9,234 | Dick Lange | Vida Blue | Dick Lange | Vida Blue | Don Kirkwood | 336 | 381 | -45 |
| 1975-07-08 | vs BAL | 86 | L 5-8 | 39-47 | 5 | 16,811 | Nolan Ryan | Jim Palmer | Doyle Alexander | Nolan Ryan | Grant Jackson | 341 | 389 | -48 |
| 1975-07-09 | vs BAL | 87 | W 3-2 | 40-47 | 5 | 10,542 | Frank Tanana | Ross Grimsley | Frank Tanana | Ross Grimsley | Don Kirkwood | 344 | 391 | -47 |
| 1975-07-10 | vs BAL | 88 | L 3-7 | 40-48 | 5 | 9,569 | Ed Figueroa | Mike Cuellar | Mike Cuellar | Ed Figueroa | | 347 | 398 | -51 |
| 1975-07-11 | vs CLE | 89 | L 3-5 | 40-49 | 5 | 9,034 | Dick Lange | Roric Harrison | Roric Harrison | Dick Lange | Dave LaRoche | 350 | 403 | -53 |
| 1975-07-12 | vs CLE | 90 | L 1-9 | 40-50 | 5 | 27,135 | Nolan Ryan | Dennis Eckersley | Dennis Eckersley | Nolan Ryan | | 351 | 412 | -61 |
| 1975-07-13 | vs CLE | 91 | L 7-8 | 40-51 | 6 | 7,493 | Frank Tanana | Don Hood | Jim Bibby | Don Kirkwood | Dave LaRoche | 358 | 420 | -62 |
| 1975-07-17 | @ MIL | 92 | W 6-1 | 41-51 | 5 | 20,738 | Ed Figueroa | Jim Colborn | Ed Figueroa | Jim Colborn | | 364 | 421 | -57 |
| 1975-07-18 | @ MIL | 93 | L 0-2 | 41-52 | 5 | 15,937 | Nolan Ryan | Jim Slaton | Jim Slaton | Nolan Ryan | | 364 | 423 | -59 |
| 1975-07-19 | @ CLE | 94 | W 8-0 | 43-52 | 5 | 0 | Frank Tanana | Dennis Eckersley | Frank Tanana | Dennis Eckersley | | 372 | 423 | -51 |
| 1975-07-19 | @ CLE | 95 | W 3-2 | 43-52 | 5 | 29,682 | Bill Singer | Roric Harrison | Don Kirkwood | Dave LaRoche | Chuck Hockenbery | 375 | 425 | -50 |
| 1975-07-20 | @ CLE | 96 | L 4-10 | 43-53 | 5 | 10,402 | Dick Lange | Don Hood | Don Hood | Dick Lange | | 379 | 435 | -56 |
| 1975-07-21 | @ CLE | 97 | L 1-2 | 43-54 | 5 | 11,012 | Ed Figueroa | Fritz Peterson | Dave LaRoche | Ed Figueroa | | 380 | 437 | -57 |
| 1975-07-22 | @ BAL | 98 | L 3-8 | 43-55 | 5 | 11,254 | Nolan Ryan | Mike Cuellar | Mike Cuellar | Nolan Ryan | | 383 | 445 | -62 |
| 1975-07-23 | @ BAL | 99 | W 1-0 | 44-55 | 5 | 12,741 | Frank Tanana | Jim Palmer | Frank Tanana | Jim Palmer | | 384 | 445 | -61 |
| 1975-07-25 | vs MIN | 100 | L 1-12 | 44-56 | 5 | 12,432 | Bill Singer | Bert Blyleven | Bert Blyleven | Bill Singer | | 385 | 457 | -72 |
| 1975-07-26 | vs MIN | 101 | L 4-9 | 45-57 | 5 | 0 | Ed Figueroa | Dave Goltz | Dave Goltz | Ed Figueroa | | 389 | 466 | -77 |
| 1975-07-26 | vs MIN | 102 | W 5-0 | 45-57 | 5 | 16,801 | Nolan Ryan | Vic Albury | Nolan Ryan | Vic Albury | Jim Brewer | 394 | 466 | -72 |
| 1975-07-27 | vs MIN | 103 | W 6-1 | 46-57 | 5 | 7,633 | Dick Lange | Jim Hughes | Dick Lange | Jim Hughes | | 400 | 467 | -67 |
| 1975-07-28 | vs CHA | 104 | L 2-3 | 46-58 | 5 | 20,973 | Frank Tanana | Wilbur Wood | Wilbur Wood | Frank Tanana | Rich Gossage | 402 | 470 | -68 |
| 1975-07-29 | vs CHA | 105 | L 4-7 | 46-59 | 5 | 7,968 | Andy Hassler | Claude Osteen | Claude Osteen | Andy Hassler | Dave Hamilton | 406 | 477 | -71 |
| 1975-07-30 | vs CHA | 106 | W 5-4 | 47-59 | 5 | 11,095 | Nolan Ryan | Jim Kaat | Nolan Ryan | Jim Kaat | | 411 | 481 | -70 |
| 1975-08-01 | @ TEX | 107 | L 1-2 | 47-60 | 5 | 30,038 | Ed Figueroa | Gaylord Perry | Gaylord Perry | Ed Figueroa | | 412 | 483 | -71 |
| 1975-08-02 | @ TEX | 108 | L 2-8 | 47-61 | 6 | 13,013 | Dick Lange | Bill Hands | Bill Hands | Dick Lange | Stan Thomas | 414 | 491 | -77 |
| 1975-08-03 | @ TEX | 109 | W 6-4 | 48-61 | 6 | 9,745 | Nolan Ryan | Steve Hargan | Don Kirkwood | Tommy Moore | | 420 | 495 | -75 |
| 1975-08-04 | @ CHA | 110 | L 2-4 | 48-62 | 6 | 5,400 | Chuck Hockenbery | Wilbur Wood | Wilbur Wood | Chuck Hockenbery | Rich Gossage | 422 | 499 | -77 |
| 1975-08-05 | @ CHA | 111 | W 10-4 | 49-63 | 6 | 0 | Ed Figueroa | Claude Osteen | Ed Figueroa | Claude Osteen | | 432 | 503 | -71 |
| 1975-08-05 | @ CHA | 112 | L 1-4 | 49-63 | 6 | 7,265 | Bill Singer | Jesse Jefferson | Jesse Jefferson | Bill Singer | Rich Gossage | 433 | 507 | -74 |
| 1975-08-06 | @ CHA | 113 | L 1-11 | 49-64 | 6 | 9,178 | Dick Lange | Jim Kaat | Jim Kaat | Dick Lange | | 434 | 518 | -84 |
| 1975-08-07 | @ CHA | 114 | L 4-8 | 49-65 | 6 | 10,543 | Andy Hassler | Pete Vuckovich | Dave Hamilton | Andy Hassler | | 438 | 526 | -88 |
| 1975-08-08 | vs NYA | 115 | L 3-4 | 49-66 | 6 | 12,176 | Nolan Ryan | Larry Gura | Larry Gura | Nolan Ryan | | 441 | 530 | -89 |
| 1975-08-09 | vs NYA | 116 | W 8-1 | 50-66 | 6 | 15,779 | Ed Figueroa | Catfish Hunter | Ed Figueroa | Catfish Hunter | | 449 | 531 | -82 |
| 1975-08-10 | vs NYA | 117 | W 1-0 | 51-66 | 6 | 11,682 | Bill Singer | Rudy May | Mickey Scott | Rudy May | | 450 | 531 | -81 |
| 1975-08-11 | vs NYA | 118 | W 8-1 | 52-66 | 6 | 9,491 | Frank Tanana | Pat Dobson | Frank Tanana | Pat Dobson | | 458 | 532 | -74 |
| 1975-08-12 | vs BOS | 119 | L 2-8 | 52-67 | 6 | 12,365 | Chuck Hockenbery | Rick Wise | Rick Wise | Chuck Hockenbery | | 460 | 540 | -80 |
| 1975-08-13 | vs BOS | 120 | W 8-3 | 53-67 | 6 | 13,750 | Ed Figueroa | Reggie Cleveland | Ed Figueroa | Reggie Cleveland | | 468 | 543 | -75 |
| 1975-08-14 | vs BOS | 121 | W 5-3 | 54-67 | 6 | 11,984 | Bill Singer | Bill Lee | Bill Singer | Bill Lee | Don Kirkwood | 473 | 546 | -73 |
| 1975-08-15 | vs DET | 122 | W 8-0 | 55-67 | 6 | 8,885 | Frank Tanana | Mickey Lolich | Frank Tanana | Mickey Lolich | | 481 | 546 | -65 |
| 1975-08-16 | vs DET | 123 | L 0-8 | 55-68 | 6 | 31,569 | Chuck Hockenbery | Ray Bare | Ray Bare | Chuck Hockenbery | | 481 | 554 | -73 |
| 1975-08-17 | vs DET | 124 | L 0-7 | 55-69 | 6 | 8,358 | Ed Figueroa | Vern Ruhle | Vern Ruhle | Ed Figueroa | | 481 | 561 | -80 |
| 1975-08-18 | vs MIL | 125 | W 5-4 | 56-69 | 6 | 18,320 | Bill Singer | Tom Hausman | Don Kirkwood | Tom Murphy | | 486 | 565 | -79 |
| 1975-08-19 | vs MIL | 126 | W 5-4 | 57-69 | 6 | 8,525 | Frank Tanana | Jim Colborn | Mickey Scott | Rick Austin | | 491 | 569 | -78 |
| 1975-08-20 | vs MIL | 127 | W 6-1 | 58-69 | 6 | 8,398 | Nolan Ryan | Jim Slaton | Nolan Ryan | Jim Slaton | | 497 | 570 | -73 |
| 1975-08-22 | @ NYA | 128 | L 2-5 | 58-70 | 6 | 15,300 | Ed Figueroa | Catfish Hunter | Catfish Hunter | Ed Figueroa | | 499 | 575 | -76 |
| 1975-08-23 | @ NYA | 129 | L 4-12 | 58-71 | 6 | 15,509 | Bill Singer | Larry Gura | Larry Gura | Bill Singer | | 503 | 587 | -84 |
| 1975-08-24 | @ NYA | 130 | W 9-0 | 60-71 | 6 | 0 | Frank Tanana | Rudy May | Frank Tanana | Rudy May | | 512 | 587 | -75 |
| 1975-08-24 | @ NYA | 131 | W 4-3 | 60-71 | 6 | 30,656 | Nolan Ryan | Tippy Martinez | Nolan Ryan | Tippy Martinez | Jim Brewer | 516 | 590 | -74 |
| 1975-08-26 | @ BOS | 132 | W 8-2 | 61-71 | 6 | 32,086 | Ed Figueroa | Luis Tiant | Ed Figueroa | Luis Tiant | | 524 | 592 | -68 |
| 1975-08-27 | @ BOS | 133 | L 2-6 | 61-72 | 6 | 34,227 | Bill Singer | Roger Moret | Roger Moret | Bill Singer | Dick Drago | 526 | 598 | -72 |
| 1975-08-29 | @ DET | 134 | W 8-1 | 62-72 | 6 | 10,451 | Frank Tanana | Mickey Lolich | Frank Tanana | Mickey Lolich | | 534 | 599 | -65 |
| 1975-08-30 | @ DET | 135 | L 2-9 | 62-73 | 6 | 7,570 | Chuck Hockenbery | Ray Bare | Ray Bare | Chuck Hockenbery | | 536 | 608 | -72 |
| 1975-09-01 | vs OAK | 136 | L 3-6 | 62-74 | 6 | 22,920 | Ed Figueroa | Vida Blue | Vida Blue | Ed Figueroa | | 539 | 614 | -75 |
| 1975-09-02 | vs OAK | 137 | W 4-1 | 63-74 | 6 | 10,952 | Frank Tanana | Ken Holtzman | Frank Tanana | Ken Holtzman | | 543 | 615 | -72 |
| 1975-09-03 | vs TEX | 138 | L 4-5 | 63-75 | 6 | 6,757 | Andy Hassler | Stan Perzanowski | Clyde Wright | Andy Hassler | Steve Foucault | 547 | 620 | -73 |
| 1975-09-04 | vs TEX | 139 | W 6-4 | 64-75 | 6 | 5,827 | Don Kirkwood | Jim Umbarger | Jim Brewer | Stan Thomas | | 553 | 624 | -71 |
| 1975-09-05 | vs KCA | 140 | L 2-5 | 64-76 | 6 | 6,902 | Ed Figueroa | Steve Busby | Steve Busby | Ed Figueroa | | 555 | 629 | -74 |
| 1975-09-06 | vs KCA | 141 | L 3-4 | 64-78 | 6 | 0 | Frank Tanana | Doug Bird | Lindy McDaniel | Frank Tanana | | 558 | 633 | -75 |
| 1975-09-06 | vs KCA | 142 | L 3-6 | 64-78 | 6 | 12,043 | Bill Singer | Marty Pattin | Marty Pattin | Bill Singer | Nelson Briles | 561 | 639 | -78 |
| 1975-09-07 | vs KCA | 143 | L 7-8 | 64-79 | 6 | 7,029 | Dick Lange | Al Fitzmorris | Mark Littell | Mickey Scott | George Throop | 568 | 647 | -79 |
| 1975-09-09 | @ CHA | 144 | W 5-4 | 65-79 | 6 | 2,958 | Ed Figueroa | Wilbur Wood | Ed Figueroa | Wilbur Wood | Jim Brewer | 573 | 651 | -78 |
| 1975-09-10 | @ CHA | 145 | W 4-2 | 66-79 | 6 | 3,233 | Frank Tanana | Jim Kaat | Frank Tanana | Jim Kaat | | 577 | 653 | -76 |
| 1975-09-12 | @ KCA | 146 | L 2-10 | 66-81 | 6 | 0 | Bill Singer | Dennis Leonard | Dennis Leonard | Bill Singer | | 579 | 663 | -84 |
| 1975-09-12 | @ KCA | 147 | L 2-7 | 66-81 | 6 | 9,749 | Don Kirkwood | Al Fitzmorris | Al Fitzmorris | Don Kirkwood | | 581 | 670 | -89 |
| 1975-09-13 | @ KCA | 148 | W 6-2 | 67-81 | 6 | 10,277 | Ed Figueroa | Doug Bird | Ed Figueroa | Doug Bird | | 587 | 672 | -85 |
| 1975-09-14 | @ KCA | 149 | L 4-10 | 67-82 | 6 | 7,473 | Frank Tanana | Steve Busby | Steve Busby | Frank Tanana | | 591 | 682 | -91 |
| 1975-09-15 | @ MIN | 150 | L 6-7 | 67-83 | 6 | 3,023 | Joe Pactwa | Bert Blyleven | Bill Campbell | Chuck Hockenbery | | 597 | 689 | -92 |
| 1975-09-16 | @ MIN | 151 | L 3-4 | 67-84 | 6 | 2,880 | Sid Monge | Jim Hughes | Jim Hughes | Sid Monge | | 600 | 693 | -93 |
| 1975-09-17 | @ TEX | 152 | W 3-2 | 68-84 | 6 | 4,942 | Ed Figueroa | David Clyde | Ed Figueroa | David Clyde | | 603 | 695 | -92 |
| 1975-09-18 | @ TEX | 153 | W 5-3 | 69-84 | 6 | 4,440 | Frank Tanana | Jim Umbarger | Frank Tanana | Jim Umbarger | | 608 | 698 | -90 |
| 1975-09-19 | vs MIN | 154 | W 1-0 | 70-84 | 6 | 8,059 | Joe Pactwa | Bert Blyleven | Joe Pactwa | Bert Blyleven | Jim Brewer | 609 | 698 | -89 |
| 1975-09-20 | vs MIN | 155 | L 2-3 | 70-85 | 6 | 9,767 | Sid Monge | Jim Hughes | Jim Hughes | Sid Monge | Tom Burgmeier | 611 | 701 | -90 |
| 1975-09-21 | vs MIN | 156 | W 5-2 | 71-85 | 6 | 8,401 | Ed Figueroa | Dave Goltz | Ed Figueroa | Dave Goltz | Jim Brewer | 616 | 703 | -87 |
| 1975-09-22 | vs CHA | 157 | W 3-0 | 72-85 | 5 | 6,173 | Frank Tanana | Jim Kaat | Don Kirkwood | Rich Gossage | | 619 | 703 | -84 |
| 1975-09-23 | vs CHA | 158 | L 4-5 | 72-86 | 6 | 6,078 | Joe Pactwa | Claude Osteen | Ozzie Osborn | Dick Lange | Dave Hamilton | 623 | 708 | -85 |
| 1975-09-26 | @ OAK | 159 | L 2-4 | 72-87 | 6 | 3,474 | Ed Figueroa | Dick Bosman | Dick Bosman | Ed Figueroa | Rollie Fingers | 625 | 712 | -87 |
| 1975-09-27 | @ OAK | 160 | L 3-6 | 72-88 | 6 | 5,177 | Frank Tanana | Ken Holtzman | Ken Holtzman | Frank Tanana | Paul Lindblad | 628 | 718 | -90 |
| 1975-09-28 | @ OAK | 161 | L 0-5 | 72-89 | 6 | 22,131 | Gary Ross | Vida Blue | Vida Blue | Gary Ross | | 628 | 723 | -95 |