| 1975-04-08 | @ BOS | 1 | L 2-5 | - | | 34,055 | Jim Slaton | Luis Tiant | Luis Tiant | Jim Slaton | | 2 | 5 | -3 |
| 1975-04-09 | @ BOS | 2 | W 7-4 | - | | 7,643 | Pete Broberg | Bill Lee | Pete Broberg | Bill Lee | Tom Murphy | 9 | 9 | 0 |
| 1975-04-11 | vs CLE | 3 | W 6-2 | - | | 48,160 | Bill Champion | Jim Perry | Bill Champion | Jim Perry | Tom Murphy | 15 | 11 | 4 |
| 1975-04-12 | vs CLE | 4 | W 6-5 | - | | 11,515 | Jim Slaton | Fritz Peterson | Jim Slaton | Fritz Peterson | Tom Murphy | 21 | 16 | 5 |
| 1975-04-13 | vs CLE | 5 | L 1-3 | - | | 22,459 | Pete Broberg | Gaylord Perry | Gaylord Perry | Pete Broberg | | 22 | 19 | 3 |
| 1975-04-15 | @ BAL | 6 | W 7-1 | - | | 6,706 | Bill Champion | Jim Palmer | Bill Champion | Jim Palmer | | 29 | 20 | 9 |
| 1975-04-16 | @ BAL | 7 | L 0-2 | - | | 7,583 | Jim Slaton | Mike Cuellar | Mike Cuellar | Jim Slaton | | 29 | 22 | 7 |
| 1975-04-18 | @ CLE | 8 | W 5-1 | - | | 8,812 | Pete Broberg | Gaylord Perry | Pete Broberg | Gaylord Perry | Tom Murphy | 34 | 23 | 11 |
| 1975-04-19 | @ CLE | 9 | W 3-0 | - | | 21,977 | Bill Champion | Jim Perry | Bill Champion | Jim Perry | | 37 | 23 | 14 |
| 1975-04-20 | @ CLE | 10 | L 4-7 | - | | 9,464 | Jim Slaton | Fritz Peterson | Fritz Peterson | Jim Slaton | Tom Buskey | 41 | 30 | 11 |
| 1975-04-22 | vs BAL | 11 | L 0-1 | - | | 7,635 | Pete Broberg | Jim Palmer | Jim Palmer | Pete Broberg | | 41 | 31 | 10 |
| 1975-04-23 | vs BAL | 12 | W 8-5 | - | | 7,815 | Bill Champion | Mike Cuellar | Eduardo Rodriguez | Bob Reynolds | Tom Murphy | 49 | 36 | 13 |
| 1975-04-26 | @ NYA | 13 | L 1-10 | - | | 11,767 | Jim Slaton | Pat Dobson | Pat Dobson | Jim Slaton | | 50 | 46 | 4 |
| 1975-04-27 | @ NYA | 14 | W 7-0 | - | | 0 | Pete Broberg | Doc Medich | Pete Broberg | Doc Medich | | 57 | 46 | 11 |
| 1975-04-27 | @ NYA | 15 | L 1-10 | - | | 41,493 | Bill Champion | Catfish Hunter | Catfish Hunter | Bill Champion | | 58 | 56 | 2 |
| 1975-04-30 | vs DET | 16 | W 6-2 | - | | 6,075 | Jim Slaton | Dave Lemanczyk | Jim Slaton | Dave Lemanczyk | Eduardo Rodriguez | 64 | 58 | 6 |
| 1975-05-01 | vs DET | 17 | W 17-3 | - | | 8,395 | Pete Broberg | Vern Ruhle | Pete Broberg | Ray Bare | Jim Colborn | 81 | 61 | 20 |
| 1975-05-02 | vs NYA | 18 | W 4-2 | - | | 14,838 | Bill Champion | Doc Medich | Bill Champion | Doc Medich | | 85 | 63 | 22 |
| 1975-05-03 | vs NYA | 19 | W 4-3 | - | | 9,454 | Ed Sprague | Rudy May | Tom Murphy | Sparky Lyle | | 89 | 66 | 23 |
| 1975-05-04 | vs NYA | 20 | W 11-4 | - | | 34,608 | Jim Slaton | Pat Dobson | Jim Slaton | Pat Dobson | | 100 | 70 | 30 |
| 1975-05-06 | @ DET | 21 | L 2-4 | - | | 11,035 | Pete Broberg | Joe Coleman | Joe Coleman | Pete Broberg | | 102 | 74 | 28 |
| 1975-05-07 | @ DET | 22 | W 7-5 | - | | 13,610 | Bill Champion | Mickey Lolich | Eduardo Rodriguez | Mickey Lolich | | 109 | 79 | 30 |
| 1975-05-08 | @ DET | 23 | L 4-6 | - | | 10,220 | Jim Slaton | Vern Ruhle | Ray Bare | Jim Colborn | John Hiller | 113 | 85 | 28 |
| 1975-05-09 | @ KCA | 24 | W 7-1 | - | | 14,553 | Ed Sprague | Al Fitzmorris | Ed Sprague | Al Fitzmorris | Tom Murphy | 120 | 86 | 34 |
| 1975-05-10 | @ KCA | 25 | W 3-0 | - | | 16,425 | Pete Broberg | Nelson Briles | Pete Broberg | Nelson Briles | Tom Murphy | 123 | 86 | 37 |
| 1975-05-11 | @ KCA | 26 | L 0-4 | - | | 11,163 | Bill Champion | Steve Busby | Steve Busby | Bill Champion | | 123 | 90 | 33 |
| 1975-05-13 | @ TEX | 27 | L 0-5 | - | | 18,696 | Jim Slaton | Jim Bibby | Jim Bibby | Jim Slaton | | 123 | 95 | 28 |
| 1975-05-14 | @ TEX | 28 | W 3-2 | - | | 12,090 | Ed Sprague | Clyde Wright | Eduardo Rodriguez | Jackie Brown | Jim Colborn | 126 | 97 | 29 |
| 1975-05-15 | @ TEX | 29 | W 8-5 | - | | 22,823 | Pete Broberg | Steve Hargan | Pete Broberg | Steve Hargan | Eduardo Rodriguez | 134 | 102 | 32 |
| 1975-05-16 | @ MIN | 30 | W 3-1 | - | | 10,026 | Bill Champion | Dave Goltz | Bill Champion | Dave Goltz | Bill Castro | 137 | 103 | 34 |
| 1975-05-17 | @ MIN | 31 | L 7-8 | - | | 12,300 | Jim Colborn | Vic Albury | Ray Corbin | Tom Murphy | Bill Campbell | 144 | 111 | 33 |
| 1975-05-18 | @ MIN | 32 | L 0-6 | - | | 12,608 | Ed Sprague | Jim Hughes | Jim Hughes | Ed Sprague | | 144 | 117 | 27 |
| 1975-05-20 | vs TEX | 33 | W 7-6 | - | | 13,971 | Pete Broberg | Jim Bibby | Eduardo Rodriguez | Jackie Brown | | 151 | 123 | 28 |
| 1975-05-21 | vs TEX | 34 | L 4-5 | - | | 12,196 | Bill Champion | Steve Hargan | Steve Hargan | Bill Champion | Steve Foucault | 155 | 128 | 27 |
| 1975-05-22 | vs TEX | 35 | L 0-6 | - | | 17,808 | Jim Colborn | Bill Hands | Bill Hands | Jim Colborn | | 155 | 134 | 21 |
| 1975-05-23 | vs MIN | 36 | L 1-2 | - | | 13,841 | Ed Sprague | Bert Blyleven | Bert Blyleven | Ed Sprague | | 156 | 136 | 20 |
| 1975-05-24 | vs MIN | 37 | L 2-3 | - | | 22,880 | Pete Broberg | Jim Hughes | Jim Hughes | Pete Broberg | | 158 | 139 | 19 |
| 1975-05-25 | vs MIN | 38 | L 2-7 | - | | 46,782 | Bill Champion | Dave Goltz | Dave Goltz | Bill Champion | | 160 | 146 | 14 |
| 1975-05-26 | vs CHA | 39 | L 2-4 | - | | 16,343 | Jim Colborn | Jim Kaat | Jim Kaat | Jim Colborn | Rich Gossage | 162 | 150 | 12 |
| 1975-05-27 | vs CHA | 40 | W 9-8 | - | | 12,066 | Ed Sprague | Wilbur Wood | Tom Hausman | Wilbur Wood | Tom Murphy | 171 | 158 | 13 |
| 1975-05-28 | vs CHA | 41 | L 3-9 | - | | 9,971 | Jim Slaton | Stan Bahnsen | Stan Bahnsen | Jim Slaton | | 174 | 167 | 7 |
| 1975-05-31 | vs KCA | 42 | L 5-7 | - | | 15,949 | Pete Broberg | Dennis Leonard | Lindy McDaniel | Pete Broberg | | 179 | 174 | 5 |
| 1975-06-01 | vs KCA | 43 | L 6-13 | - | | 0 | Bill Champion | Steve Busby | Marty Pattin | Tom Hausman | | 185 | 187 | -2 |
| 1975-06-01 | vs KCA | 44 | L 5-11 | - | | 29,759 | Jim Colborn | Al Fitzmorris | Al Fitzmorris | Jim Colborn | | 190 | 198 | -8 |
| 1975-06-02 | @ OAK | 45 | W 6-3 | - | | 28,235 | Ed Sprague | Vida Blue | Bill Castro | Vida Blue | | 196 | 201 | -5 |
| 1975-06-03 | @ OAK | 46 | W 5-4 | - | | 4,129 | Bill Travers | Jim Perry | Bill Champion | Jim Todd | Tom Murphy | 201 | 205 | -4 |
| 1975-06-04 | @ OAK | 47 | L 3-11 | - | | 3,344 | Pete Broberg | Ken Holtzman | Ken Holtzman | Pete Broberg | | 204 | 216 | -12 |
| 1975-06-06 | @ CAL | 48 | L 0-6 | - | | 29,513 | Jim Slaton | Nolan Ryan | Nolan Ryan | Jim Slaton | | 204 | 222 | -18 |
| 1975-06-07 | @ CAL | 49 | L 2-5 | - | | 14,212 | Bill Castro | Frank Tanana | Frank Tanana | Bill Castro | | 206 | 227 | -21 |
| 1975-06-08 | @ CAL | 50 | W 4-3 | - | | 22,230 | Jim Colborn | Ed Figueroa | Jim Colborn | Ed Figueroa | Tom Murphy | 210 | 230 | -20 |
| 1975-06-09 | @ CHA | 51 | W 1-0 | - | | 4,949 | Bill Travers | Claude Osteen | Eduardo Rodriguez | Rich Gossage | Tom Murphy | 211 | 230 | -19 |
| 1975-06-10 | @ CHA | 52 | L 2-9 | - | | 5,541 | Pete Broberg | Wilbur Wood | Wilbur Wood | Pete Broberg | | 213 | 239 | -26 |
| 1975-06-11 | vs OAK | 53 | L 3-5 | - | | 15,382 | Jim Slaton | Dick Bosman | Dick Bosman | Jim Slaton | Rollie Fingers | 216 | 244 | -28 |
| 1975-06-12 | vs OAK | 54 | W 9-7 | - | | 14,243 | Bill Castro | Vida Blue | Bill Castro | Vida Blue | | 225 | 251 | -26 |
| 1975-06-13 | vs CAL | 55 | W 10-2 | - | | 11,442 | Jim Colborn | Bill Singer | Jim Colborn | Bill Singer | | 235 | 253 | -18 |
| 1975-06-14 | vs CAL | 56 | W 6-4 | - | | 36,191 | Bill Travers | Nolan Ryan | Bill Travers | Nolan Ryan | Tom Murphy | 241 | 257 | -16 |
| 1975-06-15 | vs CAL | 57 | L 7-8 | - | | 0 | Eduardo Rodriguez | Frank Tanana | Don Kirkwood | Bill Champion | Mickey Scott | 248 | 265 | -17 |
| 1975-06-15 | vs CAL | 58 | W 4-2 | - | | 23,597 | Jim Slaton | Andy Hassler | Jim Slaton | Andy Hassler | Tom Murphy | 252 | 267 | -15 |
| 1975-06-16 | @ NYA | 59 | L 7-10 | - | | 10,901 | Pete Broberg | Rudy May | Dick Tidrow | Ed Sprague | Sparky Lyle | 259 | 277 | -18 |
| 1975-06-17 | @ NYA | 60 | W 4-3 | - | | 0 | Bill Castro | Pat Dobson | Bill Castro | Sparky Lyle | Tom Murphy | 263 | 280 | -17 |
| 1975-06-17 | @ NYA | 61 | L 2-4 | - | | 19,724 | Jim Colborn | Larry Gura | Dick Tidrow | Jim Colborn | | 265 | 284 | -19 |
| 1975-06-18 | @ NYA | 62 | W 5-3 | - | | 15,273 | Bill Travers | Doc Medich | Bill Travers | Doc Medich | Eduardo Rodriguez | 270 | 287 | -17 |
| 1975-06-20 | @ CLE | 63 | W 6-0 | - | | 9,355 | Jim Slaton | Roric Harrison | Jim Slaton | Roric Harrison | | 276 | 287 | -11 |
| 1975-06-21 | @ CLE | 64 | W 11-9 | - | | 11,417 | Pete Broberg | Dennis Eckersley | Pete Broberg | Dennis Eckersley | Bill Travers | 287 | 296 | -9 |
| 1975-06-22 | @ CLE | 65 | L 2-3 | - | | 25,229 | Jim Colborn | Jim Bibby | Tom Buskey | Ed Sprague | | 289 | 299 | -10 |
| 1975-06-23 | vs DET | 66 | W 8-4 | - | | 10,945 | Bill Castro | Joe Coleman | Tom Hausman | Joe Coleman | | 297 | 303 | -6 |
| 1975-06-24 | vs DET | 67 | W 5-0 | - | | 0 | Jim Slaton | Ray Bare | Jim Slaton | Ray Bare | | 302 | 303 | -1 |
| 1975-06-24 | vs DET | 68 | W 4-2 | - | | 21,199 | Bill Travers | Lerrin LaGrow | Bill Travers | Lerrin LaGrow | | 306 | 305 | 1 |
| 1975-06-25 | vs DET | 69 | W 7-6 | - | | 12,681 | Pete Broberg | Vern Ruhle | Pete Broberg | Vern Ruhle | Ed Sprague | 313 | 311 | 2 |
| 1975-06-26 | vs CLE | 70 | L 2-9 | - | | 15,145 | Jim Colborn | Dennis Eckersley | Dennis Eckersley | Jim Colborn | | 315 | 320 | -5 |
| 1975-06-27 | vs CLE | 71 | L 1-6 | - | | 17,422 | Ed Sprague | Jim Bibby | Jim Bibby | Ed Sprague | | 316 | 326 | -10 |
| 1975-06-28 | vs CLE | 72 | W 10-6 | - | | 23,360 | Jim Slaton | Eric Raich | Rick Austin | Jackie Brown | | 326 | 332 | -6 |
| 1975-06-29 | vs CLE | 73 | W 4-3 | - | | 24,640 | Pete Broberg | Don Hood | Eduardo Rodriguez | Don Hood | | 330 | 335 | -5 |
| 1975-06-30 | vs NYA | 74 | W 5-4 | - | | 16,156 | Bill Travers | Rudy May | Bill Travers | Rudy May | | 335 | 339 | -4 |
| 1975-07-01 | vs NYA | 75 | W 6-3 | - | | 20,938 | Jim Colborn | Pat Dobson | Jim Colborn | Pat Dobson | Rick Austin | 341 | 342 | -1 |
| 1975-07-02 | vs BOS | 76 | L 3-6 | - | | 0 | Bill Castro | Rick Wise | Rick Wise | Bill Castro | | 344 | 348 | -4 |
| 1975-07-02 | vs BOS | 77 | W 4-3 | - | | 34,455 | Tom Hausman | Bill Lee | Pete Broberg | Bill Lee | | 348 | 351 | -3 |
| 1975-07-03 | vs BOS | 78 | W 3-2 | - | | 16,225 | Jim Slaton | Roger Moret | Rick Austin | Diego Segui | | 351 | 353 | -2 |
| 1975-07-04 | @ DET | 79 | L 2-8 | - | | 14,259 | Bill Travers | Ray Bare | Ray Bare | Bill Travers | | 353 | 361 | -8 |
| 1975-07-05 | @ DET | 80 | L 2-3 | - | | 14,092 | Jim Colborn | Vern Ruhle | Vern Ruhle | Jim Colborn | | 355 | 364 | -9 |
| 1975-07-06 | @ DET | 81 | L 5-7 | - | | 0 | Tom Hausman | Mickey Lolich | Mickey Lolich | Tom Hausman | John Hiller | 360 | 371 | -11 |
| 1975-07-06 | @ DET | 82 | L 2-11 | - | | 24,019 | Pete Broberg | Lerrin LaGrow | Lerrin LaGrow | Pete Broberg | | 362 | 382 | -20 |
| 1975-07-07 | @ KCA | 83 | W 4-3 | - | | 12,532 | Jim Slaton | Al Fitzmorris | Jim Slaton | Al Fitzmorris | Eduardo Rodriguez | 366 | 385 | -19 |
| 1975-07-08 | @ KCA | 84 | L 1-9 | - | | 12,605 | Bill Travers | Dennis Leonard | Dennis Leonard | Bill Travers | | 367 | 394 | -27 |
| 1975-07-09 | @ KCA | 85 | W 6-4 | - | | 13,367 | Jim Colborn | Nelson Briles | Jim Colborn | Nelson Briles | Eduardo Rodriguez | 373 | 398 | -25 |
| 1975-07-11 | vs CHA | 86 | L 3-5 | - | | 19,655 | Ed Sprague | Claude Osteen | Claude Osteen | Ed Sprague | Rich Gossage | 376 | 403 | -27 |
| 1975-07-12 | vs CHA | 87 | W 5-4 | - | | 28,079 | Jim Slaton | Jim Kaat | Jim Slaton | Jim Kaat | Eduardo Rodriguez | 381 | 407 | -26 |
| 1975-07-13 | vs CHA | 88 | L 0-5 | - | | 27,386 | Bill Travers | Wilbur Wood | Wilbur Wood | Bill Travers | | 381 | 412 | -31 |
| 1975-07-17 | vs CAL | 89 | L 1-6 | - | | 20,738 | Jim Colborn | Ed Figueroa | Ed Figueroa | Jim Colborn | | 382 | 418 | -36 |
| 1975-07-18 | vs CAL | 90 | W 2-0 | - | | 15,937 | Jim Slaton | Nolan Ryan | Jim Slaton | Nolan Ryan | | 384 | 418 | -34 |
| 1975-07-19 | @ CHA | 91 | L 2-4 | - | | 20,516 | Bill Travers | Jesse Jefferson | Jesse Jefferson | Bill Travers | Rich Gossage | 386 | 422 | -36 |
| 1975-07-20 | @ CHA | 92 | L 2-9 | - | | 0 | Ed Sprague | Wilbur Wood | Wilbur Wood | Ed Sprague | | 388 | 431 | -43 |
| 1975-07-20 | @ CHA | 93 | L 5-10 | - | | 24,719 | Pete Broberg | Claude Osteen | Ozzie Osborn | Pete Broberg | Bill Gogolewski | 393 | 441 | -48 |
| 1975-07-21 | @ CHA | 94 | W 7-4 | - | | 11,550 | Jim Colborn | Claude Osteen | Jim Colborn | Claude Osteen | Rick Austin | 400 | 445 | -45 |
| 1975-07-22 | vs KCA | 95 | L 2-3 | - | | 0 | Jim Slaton | Steve Busby | Steve Busby | Jim Slaton | Paul Splittorff | 402 | 448 | -46 |
| 1975-07-22 | vs KCA | 96 | W 6-3 | - | | 15,746 | Ed Sprague | Al Fitzmorris | Tom Hausman | Al Fitzmorris | | 408 | 451 | -43 |
| 1975-07-23 | vs KCA | 97 | L 1-4 | - | | 9,531 | Bill Travers | Marty Pattin | Marty Pattin | Bill Travers | | 409 | 455 | -46 |
| 1975-07-24 | vs BAL | 98 | L 7-10 | - | | 12,162 | Pete Broberg | Ross Grimsley | Wayne Garland | Pete Broberg | Dyar Miller | 416 | 465 | -49 |
| 1975-07-25 | vs BAL | 99 | W 5-2 | - | | 30,495 | Jim Colborn | Mike Torrez | Jim Colborn | Mike Torrez | | 421 | 467 | -46 |
| 1975-07-26 | vs BAL | 100 | L 0-4 | - | | 26,578 | Jim Slaton | Mike Cuellar | Mike Cuellar | Jim Slaton | | 421 | 471 | -50 |
| 1975-07-27 | vs BAL | 101 | L 4-7 | - | | 0 | Bill Travers | Jim Palmer | Jim Palmer | Lafayette Currence | Dyar Miller | 425 | 478 | -53 |
| 1975-07-27 | vs BAL | 102 | L 6-11 | - | | 26,705 | Tom Hausman | Paul Mitchell | Dyar Miller | Rick Austin | | 431 | 489 | -58 |
| 1975-07-28 | @ BOS | 103 | L 6-7 | - | | 33,606 | Pete Broberg | Rick Wise | Jim Willoughby | Tom Murphy | | 437 | 496 | -59 |
| 1975-07-29 | @ BOS | 104 | W 4-0 | - | | 33,506 | Jim Colborn | Diego Segui | Jim Colborn | Diego Segui | | 441 | 496 | -55 |
| 1975-07-30 | @ BOS | 105 | W 6-2 | - | | 33,763 | Jim Slaton | Reggie Cleveland | Jim Slaton | Reggie Cleveland | | 447 | 498 | -51 |
| 1975-08-01 | @ BAL | 106 | L 4-6 | - | | 0 | Bill Champion | Jim Palmer | Jim Palmer | Bill Champion | Wayne Garland | 451 | 504 | -53 |
| 1975-08-01 | @ BAL | 107 | L 1-3 | - | | 19,041 | Tom Hausman | Ross Grimsley | Ross Grimsley | Tom Hausman | | 452 | 507 | -55 |
| 1975-08-02 | @ BAL | 108 | L 1-6 | - | | 23,319 | Jim Colborn | Mike Torrez | Mike Torrez | Jim Colborn | | 453 | 513 | -60 |
| 1975-08-03 | @ BAL | 109 | W 4-1 | - | | 11,319 | Jim Slaton | Mike Cuellar | Jim Slaton | Mike Cuellar | | 457 | 514 | -57 |
| 1975-08-04 | vs NYA | 110 | L 1-2 | - | | 13,544 | Bill Travers | Rudy May | Rudy May | Bill Travers | | 458 | 516 | -58 |
| 1975-08-05 | vs NYA | 111 | L 3-4 | - | | 18,898 | Tom Hausman | Catfish Hunter | Catfish Hunter | Tom Murphy | | 461 | 520 | -59 |
| 1975-08-06 | vs BOS | 112 | L 2-5 | - | | 16,556 | Jim Colborn | Jim Burton | Jim Willoughby | Tom Murphy | | 463 | 525 | -62 |
| 1975-08-07 | vs BOS | 113 | L 2-4 | - | | 24,817 | Jim Slaton | Rick Wise | Rick Wise | Jim Slaton | | 465 | 529 | -64 |
| 1975-08-08 | vs TEX | 114 | L 4-6 | - | | 19,894 | Bill Travers | Steve Hargan | Steve Hargan | Bill Travers | Steve Foucault | 469 | 535 | -66 |
| 1975-08-09 | vs TEX | 115 | L 2-4 | - | | 17,365 | Tom Hausman | Fergie Jenkins | Fergie Jenkins | Tom Hausman | | 471 | 539 | -68 |
| 1975-08-10 | vs TEX | 116 | W 7-4 | - | | 13,893 | Jim Colborn | Bill Hands | Pete Broberg | Bill Hands | Tom Murphy | 478 | 543 | -65 |
| 1975-08-11 | @ MIN | 117 | L 7-8 | - | | 11,238 | Jim Slaton | Bill Butler | Tom Johnson | Jim Slaton | | 485 | 551 | -66 |
| 1975-08-12 | @ MIN | 118 | W 7-4 | - | | 14,023 | Bill Travers | Jim Hughes | Bill Travers | Jim Hughes | Tom Murphy | 492 | 555 | -63 |
| 1975-08-13 | @ MIN | 119 | L 2-5 | - | | 12,669 | Tom Hausman | Dave Goltz | Dave Goltz | Tom Hausman | | 494 | 560 | -66 |
| 1975-08-15 | @ OAK | 120 | W 8-4 | - | | 7,279 | Jim Colborn | Vida Blue | Jim Colborn | Vida Blue | | 502 | 564 | -62 |
| 1975-08-16 | @ OAK | 121 | L 1-2 | - | | 11,104 | Jim Slaton | Ken Holtzman | Rollie Fingers | Jim Slaton | | 503 | 566 | -63 |
| 1975-08-17 | @ OAK | 122 | L 1-3 | - | | 9,436 | Pete Broberg | Stan Bahnsen | Stan Bahnsen | Pete Broberg | Rollie Fingers | 504 | 569 | -65 |
| 1975-08-18 | @ CAL | 123 | L 4-5 | - | | 18,320 | Tom Hausman | Bill Singer | Don Kirkwood | Tom Murphy | | 508 | 574 | -66 |
| 1975-08-19 | @ CAL | 124 | L 4-5 | - | | 8,525 | Jim Colborn | Frank Tanana | Mickey Scott | Rick Austin | | 512 | 579 | -67 |
| 1975-08-20 | @ CAL | 125 | L 1-6 | - | | 8,398 | Jim Slaton | Nolan Ryan | Nolan Ryan | Jim Slaton | | 513 | 585 | -72 |
| 1975-08-21 | vs OAK | 126 | L 2-5 | - | | 13,346 | Pete Broberg | Ken Holtzman | Ken Holtzman | Pete Broberg | | 515 | 590 | -75 |
| 1975-08-23 | vs OAK | 127 | L 3-6 | - | | 0 | Bill Travers | Glenn Abbott | Jim Todd | Tom Murphy | Rollie Fingers | 518 | 596 | -78 |
| 1975-08-23 | vs OAK | 128 | L 3-9 | - | | 21,036 | Tom Hausman | Stan Bahnsen | Stan Bahnsen | Tom Hausman | Jim Todd | 521 | 605 | -84 |
| 1975-08-24 | vs OAK | 129 | W 7-6 | - | | 17,231 | Jim Colborn | Dick Bosman | Eduardo Rodriguez | Rollie Fingers | Tom Murphy | 528 | 611 | -83 |
| 1975-08-25 | vs MIN | 130 | L 3-6 | - | | 7,779 | Jim Slaton | Joe Decker | Bill Butler | Jim Slaton | | 531 | 617 | -86 |
| 1975-08-26 | vs MIN | 131 | L 1-2 | - | | 9,941 | Pete Broberg | Dave Goltz | Dave Goltz | Pete Broberg | | 532 | 619 | -87 |
| 1975-08-27 | vs MIN | 132 | L 0-1 | - | | 6,261 | Bill Travers | Bert Blyleven | Bert Blyleven | Bill Travers | | 532 | 620 | -88 |
| 1975-08-29 | @ TEX | 133 | W 13-1 | - | | 13,496 | Jim Colborn | Steve Hargan | Jim Colborn | Steve Hargan | | 545 | 621 | -76 |
| 1975-08-30 | @ TEX | 134 | L 3-8 | - | | 14,962 | Jim Slaton | Jim Umbarger | Jim Umbarger | Jim Slaton | | 548 | 629 | -81 |
| 1975-08-31 | @ TEX | 135 | W 4-1 | - | | 15,037 | Pete Broberg | Gaylord Perry | Pete Broberg | Gaylord Perry | | 552 | 630 | -78 |
| 1975-09-01 | @ DET | 136 | L 4-5 | - | | 7,584 | Bill Travers | Vern Ruhle | Dave Lemanczyk | Rick Austin | | 556 | 635 | -79 |
| 1975-09-02 | @ DET | 137 | W 6-5 | - | | 6,263 | Jim Colborn | Joe Coleman | Jim Colborn | Joe Coleman | Eduardo Rodriguez | 562 | 640 | -78 |
| 1975-09-03 | vs CLE | 138 | L 3-11 | - | | 4,177 | Jim Slaton | Fritz Peterson | Fritz Peterson | Jim Slaton | Bob Reynolds | 565 | 651 | -86 |
| 1975-09-04 | vs CLE | 139 | L 5-10 | - | | 3,810 | Lafayette Currence | Roric Harrison | Roric Harrison | Lafayette Currence | | 570 | 661 | -91 |
| 1975-09-05 | vs BOS | 140 | W 4-2 | - | | 11,864 | Pete Broberg | Bill Lee | Pete Broberg | Bill Lee | | 574 | 663 | -89 |
| 1975-09-06 | vs BOS | 141 | L 6-20 | - | | 11,992 | Bill Travers | Roger Moret | Roger Moret | Bill Travers | | 580 | 683 | -103 |
| 1975-09-07 | vs BOS | 142 | L 3-6 | - | | 0 | Jim Colborn | Reggie Cleveland | Reggie Cleveland | Jim Colborn | Dick Drago | 583 | 689 | -106 |
| 1975-09-07 | vs BOS | 143 | W 7-3 | - | | 11,904 | Bill Travers | Dick Pole | Bill Travers | Dick Pole | | 590 | 692 | -102 |
| 1975-09-08 | vs BAL | 144 | L 2-6 | - | | 4,271 | Jim Slaton | Mike Torrez | Mike Torrez | Jim Slaton | | 592 | 698 | -106 |
| 1975-09-09 | vs BAL | 145 | L 1-9 | - | | 4,659 | Pete Broberg | Doyle Alexander | Doyle Alexander | Pete Broberg | | 593 | 707 | -114 |
| 1975-09-10 | @ NYA | 146 | L 2-8 | - | | 6,944 | Pat Osburn | Larry Gura | Larry Gura | Pat Osburn | | 595 | 715 | -120 |
| 1975-09-11 | @ NYA | 147 | L 2-10 | - | | 7,352 | Jim Colborn | Catfish Hunter | Catfish Hunter | Jim Colborn | | 597 | 725 | -128 |
| 1975-09-13 | @ BOS | 148 | W 9-6 | - | | 28,515 | Pete Broberg | Rick Wise | Pete Broberg | Rick Wise | Tom Murphy | 606 | 731 | -125 |
| 1975-09-13 | @ BOS | 149 | L 3-6 | - | | 20,974 | Bill Travers | Reggie Cleveland | Reggie Cleveland | Bill Travers | Jim Burton | 609 | 737 | -128 |
| 1975-09-14 | @ BOS | 150 | L 6-8 | - | | 28,187 | Jim Slaton | Bill Lee | Jim Willoughby | Tom Murphy | Dick Drago | 615 | 745 | -130 |
| 1975-09-15 | @ BOS | 151 | L 7-9 | - | | 16,302 | Jim Colborn | Roger Moret | Roger Moret | Jim Colborn | | 622 | 754 | -132 |
| 1975-09-16 | vs NYA | 152 | W 5-2 | - | | 4,882 | Jerry Augustine | Larry Gura | Jerry Augustine | Larry Gura | Tom Murphy | 627 | 756 | -129 |
| 1975-09-17 | vs NYA | 153 | L 5-6 | - | | 4,447 | Pete Broberg | Doc Medich | Sparky Lyle | Pete Broberg | | 632 | 762 | -130 |
| 1975-09-19 | @ BAL | 154 | L 5-6 | - | | 11,028 | Bill Travers | Doyle Alexander | Dyar Miller | Tom Murphy | | 637 | 768 | -131 |
| 1975-09-20 | @ BAL | 155 | L 4-5 | - | | 17,239 | Jim Colborn | Jim Palmer | Wayne Garland | Jim Colborn | | 641 | 773 | -132 |
| 1975-09-21 | @ BAL | 156 | L 0-3 | - | | 11,217 | Pete Broberg | Mike Torrez | Mike Torrez | Pete Broberg | | 641 | 776 | -135 |
| 1975-09-22 | @ CLE | 157 | L 6-7 | - | | 3,481 | Jerry Augustine | Jim Bibby | Tom Buskey | Tom Murphy | | 647 | 783 | -136 |
| 1975-09-23 | @ CLE | 158 | L 3-4 | - | | 3,042 | Bill Travers | Roric Harrison | Dave LaRoche | Bill Travers | | 650 | 787 | -137 |
| 1975-09-24 | @ CLE | 159 | W 10-3 | - | | 4,502 | Jim Colborn | Fritz Peterson | Jim Colborn | Fritz Peterson | Tom Murphy | 660 | 790 | -130 |
| 1975-09-26 | vs DET | 160 | W 3-0 | - | | 4,908 | Pete Broberg | Ray Bare | Pete Broberg | Ray Bare | | 663 | 790 | -127 |
| 1975-09-27 | vs DET | 161 | W 5-2 | - | | 7,567 | Jerry Augustine | Vern Ruhle | Jerry Augustine | Vern Ruhle | | 668 | 792 | -124 |
| 1975-09-28 | vs DET | 162 | W 7-0 | - | | 8,768 | Larry Anderson | Ed Glynn | Larry Anderson | Ed Glynn | | 675 | 792 | -117 |