| 1974-04-05 | vs DET | 1 | W 3-2 | 1-0 | 1 | 23,918 | Jim Palmer | Mickey Lolich | Jim Palmer | Mickey Lolich | Grant Jackson | 3 | 2 | 1 |
| 1974-04-06 | vs DET | 2 | L 2-3 | 1-1 | 2 | 3,749 | Dave McNally | Joe Coleman | John Hiller | Dave McNally | | 5 | 5 | 0 |
| 1974-04-07 | vs DET | 3 | W 5-1 | 2-2 | 2 | 0 | Ross Grimsley | Woodie Fryman | Ross Grimsley | Woodie Fryman | | 10 | 6 | 4 |
| 1974-04-07 | vs DET | 4 | L 4-8 | 2-2 | 2 | 16,400 | Mike Cuellar | Lerrin LaGrow | John Hiller | Grant Jackson | | 14 | 14 | 0 |
| 1974-04-11 | @ BOS | 5 | W 7-6 | 3-2 | 3 | 23,441 | Jim Palmer | Luis Tiant | Bob Reynolds | Diego Segui | | 21 | 20 | 1 |
| 1974-04-12 | @ MIL | 6 | W 5-3 | 4-2 | 1 | 9,433 | Dave McNally | Jim Slaton | Dave McNally | Jim Slaton | Grant Jackson | 26 | 23 | 3 |
| 1974-04-13 | @ MIL | 7 | L 2-3 | 4-3 | 3 | 8,569 | Ross Grimsley | Kevin Kobel | Eduardo Rodriguez | Ross Grimsley | | 28 | 26 | 2 |
| 1974-04-15 | @ MIL | 8 | L 1-6 | 4-4 | 4 | 5,865 | Mike Cuellar | Clyde Wright | Clyde Wright | Mike Cuellar | | 29 | 32 | -3 |
| 1974-04-17 | @ DET | 9 | W 6-1 | 5-4 | 2 | 12,166 | Jim Palmer | Woodie Fryman | Jim Palmer | Woodie Fryman | | 35 | 33 | 2 |
| 1974-04-19 | vs NYA | 10 | W 5-3 | 6-4 | 2 | 7,002 | Ross Grimsley | Steve Kline | Ross Grimsley | Steve Kline | Grant Jackson | 40 | 36 | 4 |
| 1974-04-20 | vs NYA | 11 | L 3-4 | 6-5 | 4 | 5,095 | Dave McNally | Mel Stottlemyre | Mel Stottlemyre | Grant Jackson | | 43 | 40 | 3 |
| 1974-04-21 | vs NYA | 12 | W 6-5 | 7-6 | 4 | 0 | Jim Palmer | Pat Dobson | Doyle Alexander | Tom Buskey | | 49 | 45 | 4 |
| 1974-04-21 | vs NYA | 13 | L 0-3 | 7-6 | 4 | 20,329 | Mike Cuellar | Sam McDowell | Sam McDowell | Mike Cuellar | Fred Beene | 49 | 48 | 1 |
| 1974-04-23 | vs CAL | 14 | W 4-3 | 8-6 | 3 | 3,743 | Ross Grimsley | Frank Tanana | Bob Reynolds | Dave Sells | | 53 | 51 | 2 |
| 1974-04-24 | vs CAL | 15 | W 4-3 | 9-6 | 1 | 3,549 | Dave McNally | Bill Singer | Dave McNally | Bill Singer | Bob Reynolds | 57 | 54 | 3 |
| 1974-04-26 | vs OAK | 16 | W 6-5 | 10-6 | 1 | 10,175 | Jim Palmer | Vida Blue | Grant Jackson | Paul Lindblad | | 63 | 59 | 4 |
| 1974-04-27 | vs OAK | 17 | L 5-11 | 10-7 | 2 | 38,253 | Mike Cuellar | Catfish Hunter | Catfish Hunter | Mike Cuellar | | 68 | 70 | -2 |
| 1974-04-28 | vs OAK | 18 | W 4-3 | 11-7 | 1 | 11,849 | Ross Grimsley | Ken Holtzman | Ross Grimsley | Ken Holtzman | Bob Reynolds | 72 | 73 | -1 |
| 1974-04-30 | @ CHA | 19 | L 1-2 | 11-8 | 1 | 5,836 | Jim Palmer | Stan Bahnsen | Stan Bahnsen | Jim Palmer | | 73 | 75 | -2 |
| 1974-05-01 | @ CHA | 20 | L 0-2 | 11-9 | 3 | 6,854 | Dave McNally | Jim Kaat | Jim Kaat | Dave McNally | Terry Forster | 73 | 77 | -4 |
| 1974-05-03 | @ CAL | 21 | L 0-2 | 11-10 | 4 | 11,139 | Ross Grimsley | Frank Tanana | Frank Tanana | Ross Grimsley | Rudy May | 73 | 79 | -6 |
| 1974-05-04 | @ CAL | 22 | L 1-3 | 11-11 | 3 | 35,084 | Jim Palmer | Bill Singer | Bill Singer | Jim Palmer | | 74 | 82 | -8 |
| 1974-05-05 | @ CAL | 23 | L 7-8 | 11-12 | 4 | 12,124 | Dave McNally | Nolan Ryan | Dick Selma | Grant Jackson | | 81 | 90 | -9 |
| 1974-05-06 | @ OAK | 24 | W 6-3 | 12-12 | 3 | 22,322 | Mike Cuellar | Paul Lindblad | Mike Cuellar | Paul Lindblad | | 87 | 93 | -6 |
| 1974-05-07 | @ OAK | 25 | W 9-3 | 13-12 | 2 | 2,718 | Ross Grimsley | Ken Holtzman | Ross Grimsley | Ken Holtzman | | 96 | 96 | 0 |
| 1974-05-08 | @ OAK | 26 | L 3-7 | 13-13 | 3 | 2,980 | Jim Palmer | Vida Blue | Vida Blue | Jim Palmer | | 99 | 103 | -4 |
| 1974-05-10 | @ CLE | 27 | W 3-1 | 14-13 | 2 | 17,889 | Dave McNally | Steve Kline | Dave McNally | Steve Kline | | 102 | 104 | -2 |
| 1974-05-11 | @ CLE | 28 | W 12-1 | 15-13 | 2 | 6,796 | Mike Cuellar | Fritz Peterson | Mike Cuellar | Fritz Peterson | | 114 | 105 | 9 |
| 1974-05-13 | vs MIL | 29 | L 4-9 | 15-14 | 2 | 5,191 | Ross Grimsley | Ed Sprague | Ed Sprague | Ross Grimsley | Tom Murphy | 118 | 114 | 4 |
| 1974-05-14 | vs MIL | 30 | L 3-8 | 15-15 | 3 | 4,611 | Jim Palmer | Bill Champion | Bill Champion | Jim Palmer | | 121 | 122 | -1 |
| 1974-05-15 | vs MIL | 31 | W 6-5 | 16-15 | 2 | 4,967 | Dave McNally | Jim Slaton | Bob Reynolds | Jim Slaton | | 127 | 127 | 0 |
| 1974-05-17 | vs BOS | 32 | W 6-0 | 17-15 | 1 | 13,178 | Mike Cuellar | Bill Lee | Mike Cuellar | Bill Lee | | 133 | 127 | 6 |
| 1974-05-18 | vs BOS | 33 | L 2-10 | 17-16 | 3 | 6,081 | Ross Grimsley | Luis Tiant | Luis Tiant | Ross Grimsley | | 135 | 137 | -2 |
| 1974-05-19 | vs BOS | 34 | L 2-11 | 17-18 | 6 | 0 | Dave McNally | Reggie Cleveland | Reggie Cleveland | Dave McNally | | 137 | 148 | -11 |
| 1974-05-19 | vs BOS | 35 | L 4-6 | 17-18 | 6 | 24,839 | Doyle Alexander | Dick Drago | Dick Drago | Doyle Alexander | | 141 | 154 | -13 |
| 1974-05-21 | vs CLE | 36 | W 7-1 | 18-18 | 3 | 4,398 | Mike Cuellar | Steve Kline | Mike Cuellar | Steve Kline | | 148 | 155 | -7 |
| 1974-05-22 | vs CLE | 37 | W 1-0 | 19-18 | 3 | 5,360 | Ross Grimsley | Jim Perry | Ross Grimsley | Tom Buskey | | 149 | 155 | -6 |
| 1974-05-23 | vs CLE | 38 | L 0-2 | 19-19 | 3 | 4,483 | Jim Palmer | Gaylord Perry | Gaylord Perry | Jim Palmer | | 149 | 157 | -8 |
| 1974-05-24 | @ NYA | 39 | W 6-3 | 20-19 | 3 | 11,369 | Dave McNally | Mel Stottlemyre | Dave McNally | Mel Stottlemyre | Bob Reynolds | 155 | 160 | -5 |
| 1974-05-25 | @ NYA | 40 | W 5-1 | 21-19 | 2 | 10,704 | Mike Cuellar | Pat Dobson | Mike Cuellar | Pat Dobson | | 160 | 161 | -1 |
| 1974-05-26 | @ NYA | 41 | L 5-6 | 21-21 | 3 | 0 | Ross Grimsley | Dick Tidrow | Dick Tidrow | Ross Grimsley | Sparky Lyle | 165 | 167 | -2 |
| 1974-05-26 | @ NYA | 42 | L 5-7 | 21-21 | 3 | 23,882 | Doyle Alexander | Dick Woodson | Mike Wallace | Doyle Alexander | Cecil Upshaw | 170 | 174 | -4 |
| 1974-05-27 | @ KCA | 43 | L 1-9 | 21-22 | 3 | 16,193 | Jim Palmer | Bruce Dal Canton | Bruce Dal Canton | Jim Palmer | | 171 | 183 | -12 |
| 1974-05-28 | @ KCA | 44 | L 5-9 | 21-23 | 5 | 10,995 | Dave McNally | Paul Splittorff | Doug Bird | Bob Reynolds | | 176 | 192 | -16 |
| 1974-05-29 | @ KCA | 45 | W 10-3 | 22-23 | 3 | 14,727 | Mike Cuellar | Steve Busby | Mike Cuellar | Steve Busby | | 186 | 195 | -9 |
| 1974-05-31 | @ TEX | 46 | L 6-7 | 22-24 | 3 | 20,984 | Ross Grimsley | Fergie Jenkins | Steve Foucault | Bob Reynolds | | 192 | 202 | -10 |
| 1974-06-01 | @ TEX | 47 | L 2-4 | 22-25 | 5 | 39,269 | Dave McNally | Jim Bibby | Jim Bibby | Dave McNally | Steve Foucault | 194 | 206 | -12 |
| 1974-06-02 | @ TEX | 48 | W 6-5 | 23-25 | 5 | 18,452 | Mike Cuellar | David Clyde | Wayne Garland | Jackie Brown | | 200 | 211 | -11 |
| 1974-06-03 | vs KCA | 49 | W 4-3 | 24-25 | 3 | 6,645 | Doyle Alexander | Steve Busby | Doyle Alexander | Steve Busby | Grant Jackson | 204 | 214 | -10 |
| 1974-06-04 | vs KCA | 50 | L 0-8 | 24-26 | 4 | 7,007 | Ross Grimsley | Al Fitzmorris | Al Fitzmorris | Ross Grimsley | | 204 | 222 | -18 |
| 1974-06-05 | vs KCA | 51 | W 5-4 | 25-26 | 4 | 7,277 | Dave McNally | Bruce Dal Canton | Bob Reynolds | Doug Bird | | 209 | 226 | -17 |
| 1974-06-07 | vs TEX | 52 | L 3-5 | 25-27 | 4 | 10,620 | Jim Palmer | David Clyde | Steve Hargan | Jim Palmer | Steve Foucault | 212 | 231 | -19 |
| 1974-06-08 | vs TEX | 53 | W 6-4 | 26-27 | 4 | 12,455 | Mike Cuellar | Fergie Jenkins | Mike Cuellar | Fergie Jenkins | Grant Jackson | 218 | 235 | -17 |
| 1974-06-09 | vs TEX | 54 | L 2-3 | 26-28 | 6 | 11,249 | Ross Grimsley | Jim Bibby | Jim Bibby | Ross Grimsley | Steve Foucault | 220 | 238 | -18 |
| 1974-06-10 | @ MIN | 55 | L 1-9 | 26-29 | 6 | 5,386 | Dave McNally | Ray Corbin | Bill Butler | Dave McNally | Bill Hands | 221 | 247 | -26 |
| 1974-06-11 | @ MIN | 56 | W 4-2 | 27-29 | 6 | 7,503 | Jim Palmer | Bert Blyleven | Jim Palmer | Bert Blyleven | Bob Reynolds | 225 | 249 | -24 |
| 1974-06-12 | @ MIN | 57 | W 4-3 | 28-29 | 6 | 6,359 | Mike Cuellar | Vic Albury | Mike Cuellar | Vic Albury | | 229 | 252 | -23 |
| 1974-06-14 | vs CHA | 58 | W 2-1 | 29-29 | 3 | 11,844 | Ross Grimsley | Skip Pitlock | Ross Grimsley | Terry Forster | | 231 | 253 | -22 |
| 1974-06-15 | vs CHA | 59 | W 4-3 | 30-29 | 3 | 19,553 | Dave McNally | Stan Bahnsen | Dave McNally | Cy Acosta | | 235 | 256 | -21 |
| 1974-06-16 | vs CHA | 60 | L 1-9 | 30-30 | 4 | 9,066 | Jim Palmer | Wilbur Wood | Wilbur Wood | Jim Palmer | | 236 | 265 | -29 |
| 1974-06-17 | vs MIN | 61 | W 1-0 | 31-30 | 4 | 7,157 | Mike Cuellar | Vic Albury | Mike Cuellar | Vic Albury | | 237 | 265 | -28 |
| 1974-06-18 | vs MIN | 62 | W 10-1 | 32-30 | 3 | 11,223 | Ross Grimsley | Joe Decker | Ross Grimsley | Joe Decker | | 247 | 266 | -19 |
| 1974-06-19 | vs MIN | 63 | W 6-5 | 33-30 | 2 | 7,325 | Dave McNally | Bill Butler | Dave McNally | Bill Butler | Wayne Garland | 253 | 271 | -18 |
| 1974-06-20 | @ MIL | 64 | L 0-6 | 33-31 | 4 | 7,383 | Doyle Alexander | Ed Sprague | Ed Sprague | Doyle Alexander | | 253 | 277 | -24 |
| 1974-06-21 | @ MIL | 65 | L 6-8 | 33-32 | 4 | 18,871 | Mike Cuellar | Bill Travers | Jim Slaton | Wayne Garland | Tom Murphy | 259 | 285 | -26 |
| 1974-06-22 | @ MIL | 66 | W 7-2 | 34-32 | 4 | 28,161 | Ross Grimsley | Kevin Kobel | Ross Grimsley | Kevin Kobel | | 266 | 287 | -21 |
| 1974-06-23 | @ MIL | 67 | L 4-9 | 34-33 | 4 | 23,946 | Dave McNally | Clyde Wright | Clyde Wright | Dave McNally | | 270 | 296 | -26 |
| 1974-06-24 | vs DET | 68 | W 3-1 | 35-33 | 4 | 6,546 | Doyle Alexander | Lerrin LaGrow | Doyle Alexander | Lerrin LaGrow | | 273 | 297 | -24 |
| 1974-06-25 | vs DET | 69 | L 0-2 | 35-34 | 4 | 10,016 | Mike Cuellar | Mickey Lolich | Mickey Lolich | Mike Cuellar | | 273 | 299 | -26 |
| 1974-06-26 | vs DET | 70 | W 5-4 | 36-34 | 4 | 8,170 | Ross Grimsley | Woodie Fryman | Ross Grimsley | John Hiller | | 278 | 303 | -25 |
| 1974-06-29 | vs NYA | 71 | W 2-0 | 37-34 | 3 | 32,905 | Dave McNally | Dick Tidrow | Dave McNally | Dick Tidrow | | 280 | 303 | -23 |
| 1974-06-30 | vs NYA | 72 | W 3-0 | 38-34 | 3 | 21,186 | Mike Cuellar | Rudy May | Mike Cuellar | Rudy May | | 283 | 303 | -20 |
| 1974-07-01 | vs BOS | 73 | L 4-6 | 38-35 | 3 | 15,696 | Doyle Alexander | Bill Lee | Bill Lee | Doyle Alexander | Diego Segui | 287 | 309 | -22 |
| 1974-07-02 | vs BOS | 74 | L 6-9 | 38-36 | 4 | 15,316 | Ross Grimsley | Roger Moret | Diego Segui | Dave Johnson | | 293 | 318 | -25 |
| 1974-07-03 | @ BOS | 75 | W 9-2 | 40-36 | 4 | 0 | Dave McNally | Dick Drago | Doyle Alexander | Dick Drago | | 302 | 320 | -18 |
| 1974-07-03 | @ BOS | 76 | W 6-4 | 40-36 | 4 | 27,730 | Wayne Garland | Reggie Cleveland | Wayne Garland | Reggie Cleveland | Dave McNally | 308 | 324 | -16 |
| 1974-07-04 | @ BOS | 77 | W 10-6 | 41-36 | 3 | 13,622 | Jesse Jefferson | Luis Tiant | Jesse Jefferson | Luis Tiant | | 318 | 330 | -12 |
| 1974-07-05 | @ OAK | 78 | L 0-6 | 41-37 | 4 | 9,671 | Mike Cuellar | Catfish Hunter | Catfish Hunter | Mike Cuellar | | 318 | 336 | -18 |
| 1974-07-06 | @ OAK | 79 | W 3-0 | 42-37 | 3 | 32,319 | Ross Grimsley | Dave Hamilton | Ross Grimsley | Dave Hamilton | | 321 | 336 | -15 |
| 1974-07-07 | @ OAK | 80 | W 4-1 | 43-37 | 3 | 10,181 | Dave McNally | Ken Holtzman | Dave McNally | Ken Holtzman | | 325 | 337 | -12 |
| 1974-07-08 | @ CAL | 81 | W 6-5 | 44-37 | 2 | 15,261 | Doyle Alexander | Andy Hassler | Wayne Garland | Andy Hassler | Dave Johnson | 331 | 342 | -11 |
| 1974-07-09 | @ CAL | 82 | W 3-1 | 45-37 | 2 | 8,213 | Mike Cuellar | Dick Lange | Mike Cuellar | Dick Lange | Bob Reynolds | 334 | 343 | -9 |
| 1974-07-10 | @ CAL | 83 | W 9-1 | 46-37 | 2 | 6,731 | Ross Grimsley | Nolan Ryan | Ross Grimsley | Nolan Ryan | | 343 | 344 | -1 |
| 1974-07-11 | @ CHA | 84 | L 3-4 | 46-38 | 3 | 11,790 | Dave McNally | Bart Johnson | Bart Johnson | Bob Reynolds | | 346 | 348 | -2 |
| 1974-07-12 | @ CHA | 85 | L 3-4 | 46-39 | 3 | 20,486 | Doyle Alexander | Jim Kaat | Rich Gossage | Doyle Alexander | | 349 | 352 | -3 |
| 1974-07-13 | @ CHA | 86 | W 2-1 | 47-39 | 2 | 25,593 | Mike Cuellar | Wilbur Wood | Mike Cuellar | Wilbur Wood | Grant Jackson | 351 | 353 | -2 |
| 1974-07-14 | @ CHA | 87 | L 1-3 | 47-40 | 3 | 18,207 | Ross Grimsley | Stan Bahnsen | Stan Bahnsen | Ross Grimsley | Rich Gossage | 352 | 356 | -4 |
| 1974-07-15 | vs OAK | 88 | L 4-6 | 47-41 | 3 | 15,510 | Wayne Garland | Glenn Abbott | Blue Moon Odom | Wayne Garland | | 356 | 362 | -6 |
| 1974-07-16 | vs OAK | 89 | L 3-4 | 47-42 | 3 | 18,429 | Doyle Alexander | Ken Holtzman | Ken Holtzman | Doyle Alexander | Rollie Fingers | 359 | 366 | -7 |
| 1974-07-17 | vs OAK | 90 | L 0-2 | 47-43 | 3 | 22,607 | Mike Cuellar | Vida Blue | Vida Blue | Mike Cuellar | Rollie Fingers | 359 | 368 | -9 |
| 1974-07-19 | vs CAL | 91 | W 5-4 | 48-43 | 2 | 14,027 | Ross Grimsley | Dick Lange | Don Hood | Skip Lockwood | | 364 | 372 | -8 |
| 1974-07-20 | vs CAL | 92 | L 0-2 | 49-44 | 3 | 0 | Wayne Garland | Nolan Ryan | Nolan Ryan | Wayne Garland | | 364 | 374 | -10 |
| 1974-07-20 | vs CAL | 93 | W 5-2 | 49-44 | 3 | 23,379 | Mike Cuellar | Ed Figueroa | Mike Cuellar | Ed Figueroa | | 369 | 376 | -7 |
| 1974-07-21 | vs CAL | 94 | L 4-6 | 49-45 | 3 | 13,443 | Dave McNally | Andy Hassler | Frank Tanana | Dave McNally | | 373 | 382 | -9 |
| 1974-07-25 | @ CLE | 95 | L 7-8 | 49-47 | 3 | 0 | Dave McNally | Dick Bosman | Dick Bosman | Dave McNally | Tom Buskey | 380 | 390 | -10 |
| 1974-07-25 | @ CLE | 96 | L 4-5 | 49-47 | 3 | 26,296 | Ross Grimsley | Fritz Peterson | Tom Hilgendorf | Bob Reynolds | | 384 | 395 | -11 |
| 1974-07-26 | @ CLE | 97 | W 9-5 | 50-47 | 3 | 42,818 | Mike Cuellar | Gaylord Perry | Dave Johnson | Gaylord Perry | | 393 | 400 | -7 |
| 1974-07-27 | vs MIL | 98 | L 3-5 | 50-48 | 3 | 26,680 | Wayne Garland | Bill Champion | Bill Champion | Wayne Garland | Tom Murphy | 396 | 405 | -9 |
| 1974-07-28 | vs MIL | 99 | L 0-4 | 50-49 | 3 | 13,286 | Doyle Alexander | Jim Slaton | Jim Slaton | Doyle Alexander | | 396 | 409 | -13 |
| 1974-07-29 | vs MIL | 100 | W 6-2 | 51-49 | 3 | 6,030 | Ross Grimsley | Clyde Wright | Ross Grimsley | Clyde Wright | | 402 | 411 | -9 |
| 1974-07-30 | vs CLE | 101 | L 6-8 | 51-50 | 3 | 11,379 | Mike Cuellar | Dick Bosman | Dick Bosman | Mike Cuellar | | 408 | 419 | -11 |
| 1974-07-31 | vs CLE | 102 | W 7-4 | 52-50 | 3 | 12,781 | Dave McNally | Gaylord Perry | Dave McNally | Gaylord Perry | | 415 | 423 | -8 |
| 1974-08-01 | @ BOS | 103 | L 3-11 | 52-51 | 3 | 27,596 | Wayne Garland | Bill Lee | Bill Lee | Wayne Garland | | 418 | 434 | -16 |
| 1974-08-02 | @ BOS | 104 | L 5-7 | 52-52 | 3 | 25,046 | Jesse Jefferson | Rick Wise | Juan Marichal | Doyle Alexander | | 423 | 441 | -18 |
| 1974-08-03 | @ DET | 105 | W 6-2 | 53-52 | 3 | 30,019 | Ross Grimsley | Mickey Lolich | Ross Grimsley | Mickey Lolich | | 429 | 443 | -14 |
| 1974-08-04 | @ DET | 106 | L 1-6 | 54-53 | 3 | 0 | Mike Cuellar | Joe Coleman | Joe Coleman | Mike Cuellar | | 430 | 449 | -19 |
| 1974-08-04 | @ DET | 107 | W 9-3 | 54-53 | 3 | 34,317 | Dave McNally | Lerrin LaGrow | Dave McNally | Lerrin LaGrow | | 439 | 452 | -13 |
| 1974-08-05 | @ DET | 108 | W 7-4 | 56-53 | 3 | 0 | Wayne Garland | Woodie Fryman | Wayne Garland | Woodie Fryman | Ross Grimsley | 446 | 456 | -10 |
| 1974-08-05 | @ DET | 109 | W 6-3 | 56-53 | 3 | 37,030 | Doyle Alexander | Luke Walker | Doyle Alexander | Luke Walker | Grant Jackson | 452 | 459 | -7 |
| 1974-08-06 | @ NYA | 110 | W 4-1 | 57-53 | 3 | 16,818 | Don Hood | Dick Tidrow | Dave Johnson | Dick Tidrow | Grant Jackson | 456 | 460 | -4 |
| 1974-08-07 | @ NYA | 111 | L 3-4 | 57-54 | 3 | 9,972 | Ross Grimsley | Pat Dobson | Pat Dobson | Ross Grimsley | Cecil Upshaw | 459 | 464 | -5 |
| 1974-08-09 | @ MIN | 112 | L 2-6 | 57-55 | 3 | 14,390 | Dave McNally | Bill Hands | Bill Hands | Dave McNally | | 461 | 470 | -9 |
| 1974-08-10 | @ MIN | 113 | L 1-5 | 57-56 | 3 | 15,493 | Mike Cuellar | Bert Blyleven | Bert Blyleven | Mike Cuellar | | 462 | 475 | -13 |
| 1974-08-11 | @ MIN | 114 | L 4-5 | 57-57 | 3 | 27,363 | Ross Grimsley | Dave Goltz | Dave Goltz | Ross Grimsley | Bill Campbell | 466 | 480 | -14 |
| 1974-08-13 | vs CHA | 115 | W 8-2 | 58-57 | 3 | 10,086 | Jim Palmer | Bart Johnson | Jim Palmer | Bart Johnson | Grant Jackson | 474 | 482 | -8 |
| 1974-08-14 | vs CHA | 116 | L 4-5 | 58-58 | 3 | 8,727 | Dave McNally | Wilbur Wood | Terry Forster | Doyle Alexander | | 478 | 487 | -9 |
| 1974-08-15 | vs CHA | 117 | W 2-1 | 59-58 | 3 | 7,839 | Mike Cuellar | Jim Kaat | Mike Cuellar | Jim Kaat | | 480 | 488 | -8 |
| 1974-08-16 | vs KCA | 118 | W 1-0 | 60-58 | 3 | 18,896 | Ross Grimsley | Bruce Dal Canton | Ross Grimsley | Bruce Dal Canton | | 481 | 488 | -7 |
| 1974-08-17 | vs KCA | 119 | L 2-3 | 60-59 | 3 | 19,665 | Jim Palmer | Paul Splittorff | Steve Mingori | Bob Reynolds | | 483 | 491 | -8 |
| 1974-08-18 | vs KCA | 120 | W 1-0 | 61-59 | 3 | 10,193 | Dave McNally | Steve Busby | Dave McNally | Steve Busby | | 484 | 491 | -7 |
| 1974-08-20 | vs TEX | 121 | W 2-1 | 62-59 | 3 | 7,482 | Mike Cuellar | Jackie Brown | Mike Cuellar | Jackie Brown | | 486 | 492 | -6 |
| 1974-08-21 | vs TEX | 122 | L 1-5 | 62-60 | 3 | 9,562 | Ross Grimsley | Jim Bibby | Jim Bibby | Ross Grimsley | Steve Foucault | 487 | 497 | -10 |
| 1974-08-22 | vs TEX | 123 | L 2-6 | 62-61 | 3 | 7,455 | Jim Palmer | Fergie Jenkins | Fergie Jenkins | Jim Palmer | | 489 | 503 | -14 |
| 1974-08-23 | vs MIN | 124 | W 4-1 | 63-61 | 3 | 9,390 | Dave McNally | Dave Goltz | Dave McNally | Dave Goltz | | 493 | 504 | -11 |
| 1974-08-24 | vs MIN | 125 | L 5-9 | 63-62 | 4 | 11,348 | Mike Cuellar | Joe Decker | Ray Corbin | Mike Cuellar | Bill Campbell | 498 | 513 | -15 |
| 1974-08-25 | vs MIN | 126 | L 1-5 | 63-63 | 3 | 10,951 | Ross Grimsley | Bert Blyleven | Bert Blyleven | Ross Grimsley | | 499 | 518 | -19 |
| 1974-08-27 | @ TEX | 127 | L 1-2 | 63-64 | 4 | 29,699 | Jim Palmer | Fergie Jenkins | Fergie Jenkins | Jim Palmer | | 500 | 520 | -20 |
| 1974-08-28 | @ TEX | 128 | L 2-4 | 63-65 | 4 | 6,069 | Dave McNally | Jackie Brown | Jackie Brown | Dave McNally | | 502 | 524 | -22 |
| 1974-08-29 | @ TEX | 129 | W 6-2 | 64-65 | 4 | 6,436 | Ross Grimsley | Jim Bibby | Ross Grimsley | Jim Bibby | | 508 | 526 | -18 |
| 1974-08-30 | @ KCA | 130 | W 9-2 | 65-65 | 4 | 16,277 | Mike Cuellar | Bruce Dal Canton | Mike Cuellar | Bruce Dal Canton | | 517 | 528 | -11 |
| 1974-08-31 | @ KCA | 131 | W 3-2 | 66-65 | 4 | 18,737 | Jim Palmer | Paul Splittorff | Jim Palmer | Paul Splittorff | Grant Jackson | 520 | 530 | -10 |
| 1974-09-01 | @ KCA | 132 | W 7-1 | 67-65 | 3 | 15,499 | Dave McNally | Steve Busby | Dave McNally | Steve Busby | | 527 | 531 | -4 |
| 1974-09-02 | vs BOS | 133 | W 1-0 | 69-65 | 3 | 0 | Ross Grimsley | Luis Tiant | Ross Grimsley | Luis Tiant | | 528 | 531 | -3 |
| 1974-09-02 | vs BOS | 134 | W 1-0 | 69-65 | 3 | 29,053 | Mike Cuellar | Bill Lee | Mike Cuellar | Bill Lee | | 529 | 531 | -2 |
| 1974-09-04 | vs BOS | 135 | W 6-0 | 70-65 | 3 | 16,856 | Jim Palmer | Roger Moret | Jim Palmer | Roger Moret | | 535 | 531 | 4 |
| 1974-09-06 | @ CLE | 136 | W 2-0 | 72-65 | 2 | 0 | Dave McNally | Fritz Peterson | Dave McNally | Fritz Peterson | | 537 | 531 | 6 |
| 1974-09-06 | @ CLE | 137 | W 1-0 | 72-65 | 2 | 27,341 | Mike Cuellar | Jim Kern | Mike Cuellar | Jim Kern | | 538 | 531 | 7 |
| 1974-09-07 | @ CLE | 138 | W 3-2 | 73-65 | 2 | 9,890 | Ross Grimsley | Gaylord Perry | Ross Grimsley | Gaylord Perry | Bob Reynolds | 541 | 533 | 8 |
| 1974-09-08 | @ CLE | 139 | L 4-7 | 73-66 | 3 | 15,985 | Jim Palmer | Jim Perry | Jim Perry | Jim Palmer | Tom Buskey | 545 | 540 | 5 |
| 1974-09-09 | @ MIL | 140 | W 6-5 | 74-66 | 2 | 5,268 | Mike Cuellar | Kevin Kobel | Bob Reynolds | Tom Murphy | Dave Johnson | 551 | 545 | 6 |
| 1974-09-10 | @ MIL | 141 | L 5-6 | 74-67 | 2 | 5,718 | Dave McNally | Bill Champion | Tom Murphy | Grant Jackson | | 556 | 551 | 5 |
| 1974-09-11 | vs NYA | 142 | W 3-2 | 75-68 | 2 | 0 | Ross Grimsley | Rudy May | Grant Jackson | Cecil Upshaw | | 559 | 553 | 6 |
| 1974-09-11 | vs NYA | 143 | L 1-5 | 75-68 | 2 | 28,923 | Don Hood | Larry Gura | Larry Gura | Don Hood | | 560 | 558 | 2 |
| 1974-09-12 | vs NYA | 144 | L 0-3 | 75-69 | 3 | 14,909 | Jim Palmer | Mike Wallace | Mike Wallace | Jim Palmer | Dick Tidrow | 560 | 561 | -1 |
| 1974-09-13 | vs CLE | 145 | W 3-2 | 77-69 | 3 | 0 | Mike Cuellar | Dick Bosman | Mike Cuellar | Dick Bosman | | 563 | 563 | 0 |
| 1974-09-13 | vs CLE | 146 | W 8-6 | 77-69 | 3 | 16,283 | Doyle Alexander | Jim Kern | Bob Reynolds | Tom Buskey | Grant Jackson | 571 | 569 | 2 |
| 1974-09-14 | vs CLE | 147 | W 7-1 | 78-69 | 2 | 11,715 | Dave McNally | Fritz Peterson | Dave McNally | Fritz Peterson | | 578 | 570 | 8 |
| 1974-09-15 | vs CLE | 148 | L 0-1 | 78-70 | 2 | 15,032 | Ross Grimsley | Gaylord Perry | Gaylord Perry | Ross Grimsley | | 578 | 571 | 7 |
| 1974-09-17 | @ NYA | 149 | W 4-0 | 79-70 | 2 | 33,784 | Jim Palmer | Doc Medich | Jim Palmer | Doc Medich | | 582 | 571 | 11 |
| 1974-09-18 | @ NYA | 150 | W 10-4 | 80-70 | 2 | 31,093 | Mike Cuellar | Pat Dobson | Mike Cuellar | Pat Dobson | | 592 | 575 | 17 |
| 1974-09-19 | @ NYA | 151 | W 7-0 | 81-70 | 1 | 21,795 | Dave McNally | Rudy May | Dave McNally | Rudy May | | 599 | 575 | 24 |
| 1974-09-20 | @ BOS | 152 | W 2-1 | 82-70 | 1 | 27,283 | Ross Grimsley | Dick Drago | Ross Grimsley | Dick Drago | Grant Jackson | 601 | 576 | 25 |
| 1974-09-21 | @ BOS | 153 | L 5-6 | 82-71 | 2 | 21,555 | Jim Palmer | Bill Lee | Bill Lee | Dave Johnson | | 606 | 582 | 24 |
| 1974-09-22 | @ BOS | 154 | W 7-2 | 83-71 | 2 | 26,495 | Mike Cuellar | Reggie Cleveland | Mike Cuellar | Reggie Cleveland | | 613 | 584 | 29 |
| 1974-09-24 | vs DET | 155 | W 5-4 | 84-71 | 1 | 11,492 | Dave McNally | Vern Ruhle | Bob Reynolds | John Hiller | | 618 | 588 | 30 |
| 1974-09-25 | vs DET | 156 | W 5-4 | 85-71 | 1 | 10,542 | Ross Grimsley | Mickey Lolich | Wayne Garland | Mickey Lolich | | 623 | 592 | 31 |
| 1974-09-27 | vs MIL | 157 | W 1-0 | 86-71 | 1 | 17,695 | Jim Palmer | Jim Colborn | Grant Jackson | Tom Murphy | | 624 | 592 | 32 |
| 1974-09-28 | vs MIL | 158 | W 7-1 | 87-71 | 1 | 12,093 | Mike Cuellar | Bill Champion | Mike Cuellar | Bill Champion | | 631 | 593 | 38 |
| 1974-09-29 | vs MIL | 159 | W 4-3 | 88-71 | 1 | 20,456 | Dave McNally | Jim Slaton | Grant Jackson | Jim Slaton | | 635 | 596 | 39 |
| 1974-09-30 | @ DET | 160 | W 12-6 | 89-71 | 1 | 6,575 | Ross Grimsley | Mickey Lolich | Grant Jackson | Mickey Lolich | | 647 | 602 | 45 |
| 1974-10-01 | @ DET | 161 | W 7-6 | 90-71 | 1 | 3,673 | Jim Palmer | Joe Coleman | Grant Jackson | John Hiller | Bob Reynolds | 654 | 608 | 46 |
| 1974-10-02 | @ DET | 162 | W 5-4 | 91-71 | 1 | 4,671 | Mike Cuellar | Lerrin LaGrow | Doyle Alexander | Lerrin LaGrow | Don Hood | 659 | 612 | 47 |