| 1974-04-04 | @ TEX | 1 | W 7-2 | 1-0 | 1 | 21,907 | Catfish Hunter | Jim Bibby | Catfish Hunter | Jim Bibby | | 7 | 2 | 5 |
| 1974-04-06 | @ TEX | 2 | L 0-2 | 1-1 | 4 | 16,965 | Ken Holtzman | Fergie Jenkins | Fergie Jenkins | Ken Holtzman | | 7 | 4 | 3 |
| 1974-04-07 | @ TEX | 3 | W 8-4 | 2-1 | 1 | 12,901 | Vida Blue | Pete Broberg | Rollie Fingers | Pete Broberg | | 15 | 8 | 7 |
| 1974-04-09 | @ KCA | 4 | W 6-4 | 3-1 | 1 | 17,792 | Catfish Hunter | Paul Splittorff | Darold Knowles | Gene Garber | Paul Lindblad | 21 | 12 | 9 |
| 1974-04-10 | @ KCA | 5 | L 1-4 | 3-2 | 2 | 14,679 | Ken Holtzman | Steve Busby | Steve Busby | Ken Holtzman | | 22 | 16 | 6 |
| 1974-04-13 | vs TEX | 6 | L 3-10 | 3-3 | 4 | 22,743 | Vida Blue | Jim Bibby | Jim Bibby | Vida Blue | | 25 | 26 | -1 |
| 1974-04-14 | vs TEX | 7 | W 4-2 | 4-4 | 4 | 0 | Catfish Hunter | Steve Hargan | Catfish Hunter | Steve Hargan | | 29 | 28 | 1 |
| 1974-04-14 | vs TEX | 8 | L 2-10 | 4-4 | 4 | 11,125 | Blue Moon Odom | Fergie Jenkins | Fergie Jenkins | Blue Moon Odom | | 31 | 38 | -7 |
| 1974-04-15 | vs CHA | 9 | W 4-3 | 5-4 | 3 | 5,718 | Ken Holtzman | Jim Kaat | Rollie Fingers | Terry Forster | | 35 | 41 | -6 |
| 1974-04-16 | vs CHA | 10 | W 4-3 | 6-4 | 3 | 3,641 | Paul Lindblad | Wilbur Wood | Paul Lindblad | Wilbur Wood | Rollie Fingers | 39 | 44 | -5 |
| 1974-04-17 | vs CHA | 11 | L 3-5 | 6-5 | 3 | 3,465 | Vida Blue | Stan Bahnsen | Stan Bahnsen | Vida Blue | | 42 | 49 | -7 |
| 1974-04-19 | vs CAL | 12 | W 5-1 | 7-5 | 2 | 5,347 | Catfish Hunter | Bill Singer | Catfish Hunter | Bill Singer | | 47 | 50 | -3 |
| 1974-04-20 | vs CAL | 13 | W 7-6 | 8-5 | 1 | 5,985 | Ken Holtzman | Nolan Ryan | Rollie Fingers | Dick Selma | | 54 | 56 | -2 |
| 1974-04-21 | vs CAL | 14 | L 5-9 | 8-6 | 2 | 8,449 | Vida Blue | Bill Stoneman | Skip Lockwood | Rollie Fingers | | 59 | 65 | -6 |
| 1974-04-23 | @ CLE | 15 | L 1-2 | 8-7 | 3 | 1,405 | Catfish Hunter | Gaylord Perry | Gaylord Perry | Catfish Hunter | | 60 | 67 | -7 |
| 1974-04-24 | @ CLE | 16 | W 9-2 | 9-7 | 3 | 1,564 | Ken Holtzman | Dick Tidrow | Ken Holtzman | Dick Tidrow | | 69 | 69 | 0 |
| 1974-04-26 | @ BAL | 17 | L 5-6 | 9-8 | 3 | 10,175 | Vida Blue | Jim Palmer | Grant Jackson | Paul Lindblad | | 74 | 75 | -1 |
| 1974-04-27 | @ BAL | 18 | W 11-5 | 10-8 | 2 | 38,253 | Catfish Hunter | Mike Cuellar | Catfish Hunter | Mike Cuellar | | 85 | 80 | 5 |
| 1974-04-28 | @ BAL | 19 | L 3-4 | 10-9 | 3 | 11,849 | Ken Holtzman | Ross Grimsley | Ross Grimsley | Ken Holtzman | Bob Reynolds | 88 | 84 | 4 |
| 1974-04-30 | @ NYA | 20 | L 3-4 | 10-10 | 2 | 10,199 | Vida Blue | Mel Stottlemyre | Mel Stottlemyre | Vida Blue | Sparky Lyle | 91 | 88 | 3 |
| 1974-05-01 | @ NYA | 21 | L 3-4 | 10-11 | 4 | 7,600 | Catfish Hunter | Pat Dobson | Pat Dobson | Catfish Hunter | Sparky Lyle | 94 | 92 | 2 |
| 1974-05-03 | vs CLE | 22 | W 3-1 | 11-11 | 3 | 4,460 | Ken Holtzman | Jim Perry | Ken Holtzman | Jim Perry | Rollie Fingers | 97 | 93 | 4 |
| 1974-05-04 | vs CLE | 23 | L 2-8 | 11-12 | 5 | 4,884 | Vida Blue | Gaylord Perry | Gaylord Perry | Vida Blue | | 99 | 101 | -2 |
| 1974-05-05 | vs CLE | 24 | W 3-0 | 12-13 | 5 | 0 | Catfish Hunter | Steve Kline | Catfish Hunter | Steve Kline | | 102 | 101 | 1 |
| 1974-05-05 | vs CLE | 25 | L 3-9 | 12-13 | 5 | 10,100 | Blue Moon Odom | Bob Johnson | Bob Johnson | Blue Moon Odom | Tom Buskey | 105 | 110 | -5 |
| 1974-05-06 | vs BAL | 26 | L 3-6 | 12-14 | 5 | 22,322 | Paul Lindblad | Mike Cuellar | Mike Cuellar | Paul Lindblad | | 108 | 116 | -8 |
| 1974-05-07 | vs BAL | 27 | L 3-9 | 12-15 | 5 | 2,718 | Ken Holtzman | Ross Grimsley | Ross Grimsley | Ken Holtzman | | 111 | 125 | -14 |
| 1974-05-08 | vs BAL | 28 | W 7-3 | 13-15 | 5 | 2,980 | Vida Blue | Jim Palmer | Vida Blue | Jim Palmer | | 118 | 128 | -10 |
| 1974-05-10 | vs MIN | 29 | W 4-2 | 14-15 | 5 | 4,755 | Catfish Hunter | Bert Blyleven | Catfish Hunter | Bert Blyleven | Darold Knowles | 122 | 130 | -8 |
| 1974-05-11 | vs MIN | 30 | W 4-1 | 15-15 | 3 | 6,107 | Ken Holtzman | Vic Albury | Ken Holtzman | Vic Albury | Rollie Fingers | 126 | 131 | -5 |
| 1974-05-12 | vs MIN | 31 | W 9-2 | 16-15 | 2 | 5,549 | Dave Hamilton | Joe Decker | Dave Hamilton | Joe Decker | | 135 | 133 | 2 |
| 1974-05-13 | vs KCA | 32 | W 11-2 | 17-15 | 1 | 3,615 | Vida Blue | Marty Pattin | Vida Blue | Marty Pattin | | 146 | 135 | 11 |
| 1974-05-14 | vs KCA | 33 | L 2-4 | 18-16 | 1 | 0 | Catfish Hunter | Paul Splittorff | Paul Splittorff | Catfish Hunter | Doug Bird | 148 | 139 | 9 |
| 1974-05-14 | vs KCA | 34 | W 2-1 | 18-16 | 1 | 7,271 | Glenn Abbott | Lindy McDaniel | Rollie Fingers | Lindy McDaniel | | 150 | 140 | 10 |
| 1974-05-16 | @ CHA | 35 | L 3-4 | 18-17 | 2 | 12,818 | Ken Holtzman | Wilbur Wood | Wilbur Wood | Ken Holtzman | Terry Forster | 153 | 144 | 9 |
| 1974-05-17 | @ CHA | 36 | W 10-4 | 19-17 | 2 | 17,772 | Dave Hamilton | Jim Kaat | Dave Hamilton | Jim Kaat | | 163 | 148 | 15 |
| 1974-05-18 | @ CHA | 37 | L 2-3 | 19-18 | 2 | 19,064 | Vida Blue | Bill Moran | Bill Moran | Vida Blue | Terry Forster | 165 | 151 | 14 |
| 1974-05-19 | @ CHA | 38 | W 8-3 | 20-18 | 2 | 16,223 | Catfish Hunter | Stan Bahnsen | Catfish Hunter | Stan Bahnsen | | 173 | 154 | 19 |
| 1974-05-20 | @ MIN | 39 | W 5-4 | 21-18 | 1 | 5,466 | Ken Holtzman | Bill Butler | Ken Holtzman | Bill Butler | Darold Knowles | 178 | 158 | 20 |
| 1974-05-21 | @ MIN | 40 | W 8-1 | 22-18 | 1 | 4,639 | Dave Hamilton | Joe Decker | Dave Hamilton | Joe Decker | | 186 | 159 | 27 |
| 1974-05-22 | @ MIN | 41 | W 7-4 | 23-18 | 1 | 4,956 | Vida Blue | Dave Goltz | Paul Lindblad | Bill Campbell | | 193 | 163 | 30 |
| 1974-05-24 | @ CAL | 42 | L 3-4 | 23-19 | 1 | 24,855 | Catfish Hunter | Dick Lange | Dick Lange | Catfish Hunter | Dave Sells | 196 | 167 | 29 |
| 1974-05-25 | @ CAL | 43 | L 2-8 | 23-20 | 1 | 17,798 | Ken Holtzman | Frank Tanana | Frank Tanana | Ken Holtzman | | 198 | 175 | 23 |
| 1974-05-26 | @ CAL | 44 | W 6-5 | 24-20 | 1 | 13,329 | Dave Hamilton | Bill Singer | Rollie Fingers | Dave Sells | | 204 | 180 | 24 |
| 1974-05-27 | vs DET | 45 | W 12-2 | 25-20 | 1 | 10,084 | Vida Blue | Joe Coleman | Vida Blue | Joe Coleman | | 216 | 182 | 34 |
| 1974-05-28 | vs DET | 46 | L 1-3 | 25-21 | 1 | 3,093 | Catfish Hunter | Woodie Fryman | Woodie Fryman | Catfish Hunter | John Hiller | 217 | 185 | 32 |
| 1974-05-29 | vs DET | 47 | W 4-1 | 26-21 | 1 | 3,783 | Ken Holtzman | Lerrin LaGrow | Ken Holtzman | Lerrin LaGrow | | 221 | 186 | 35 |
| 1974-05-31 | vs MIL | 48 | W 5-2 | 27-21 | 1 | 5,526 | Dave Hamilton | Kevin Kobel | Dave Hamilton | Kevin Kobel | Rollie Fingers | 226 | 188 | 38 |
| 1974-06-01 | vs MIL | 49 | W 4-1 | 28-21 | 1 | 6,920 | Vida Blue | Jim Slaton | Vida Blue | Jim Slaton | | 230 | 189 | 41 |
| 1974-06-02 | vs MIL | 50 | W 6-4 | 29-21 | 1 | 9,309 | Catfish Hunter | Clyde Wright | Catfish Hunter | Clyde Wright | Rollie Fingers | 236 | 193 | 43 |
| 1974-06-04 | @ DET | 51 | W 4-0 | 30-22 | 1 | 0 | Ken Holtzman | Mickey Lolich | Ken Holtzman | Mickey Lolich | | 240 | 193 | 47 |
| 1974-06-04 | @ DET | 52 | L 1-4 | 30-22 | 1 | 33,331 | Dave Hamilton | Lerrin LaGrow | Lerrin LaGrow | Dave Hamilton | | 241 | 197 | 44 |
| 1974-06-05 | @ DET | 53 | W 9-1 | 31-22 | 1 | 20,607 | Vida Blue | Joe Coleman | Vida Blue | Joe Coleman | | 250 | 198 | 52 |
| 1974-06-07 | @ MIL | 54 | L 4-6 | 31-23 | 1 | 11,395 | Catfish Hunter | Bill Champion | Jim Colborn | Catfish Hunter | | 254 | 204 | 50 |
| 1974-06-08 | @ MIL | 55 | L 2-3 | 31-24 | 1 | 25,803 | Dave Hamilton | Kevin Kobel | Eduardo Rodriguez | Rollie Fingers | | 256 | 207 | 49 |
| 1974-06-09 | @ MIL | 56 | W 5-4 | 32-24 | 1 | 46,812 | Ken Holtzman | Jim Slaton | Ken Holtzman | Jim Slaton | Paul Lindblad | 261 | 211 | 50 |
| 1974-06-10 | @ BOS | 57 | L 1-4 | 32-25 | 1 | 28,537 | Vida Blue | Luis Tiant | Luis Tiant | Vida Blue | | 262 | 215 | 47 |
| 1974-06-11 | @ BOS | 58 | L 9-10 | 32-26 | 1 | 24,762 | Catfish Hunter | Reggie Cleveland | Diego Segui | Catfish Hunter | Bob Veale | 271 | 225 | 46 |
| 1974-06-12 | @ BOS | 59 | L 3-5 | 32-27 | 1 | 27,079 | Dave Hamilton | Dick Drago | Dick Drago | Darold Knowles | | 274 | 230 | 44 |
| 1974-06-14 | vs NYA | 60 | L 1-5 | 32-28 | 1 | 8,435 | Ken Holtzman | Dick Tidrow | Dick Tidrow | Ken Holtzman | | 275 | 235 | 40 |
| 1974-06-15 | vs NYA | 61 | W 9-1 | 33-28 | 1 | 27,016 | Vida Blue | Doc Medich | Vida Blue | Doc Medich | | 284 | 236 | 48 |
| 1974-06-16 | vs NYA | 62 | L 3-5 | 33-29 | 1 | 12,530 | Catfish Hunter | Pat Dobson | Pat Dobson | Catfish Hunter | | 287 | 241 | 46 |
| 1974-06-17 | vs BOS | 63 | W 3-2 | 34-29 | 1 | 37,095 | Dave Hamilton | Dick Drago | Rollie Fingers | Dick Drago | | 290 | 243 | 47 |
| 1974-06-18 | vs BOS | 64 | L 1-6 | 34-30 | 1 | 3,033 | Ken Holtzman | Roger Moret | Roger Moret | Ken Holtzman | | 291 | 249 | 42 |
| 1974-06-19 | vs BOS | 65 | L 1-2 | 34-31 | 1 | 7,281 | Vida Blue | Luis Tiant | Luis Tiant | Vida Blue | Diego Segui | 292 | 251 | 41 |
| 1974-06-20 | vs KCA | 66 | W 4-0 | 35-31 | 1 | 4,662 | Catfish Hunter | Al Fitzmorris | Catfish Hunter | Al Fitzmorris | | 296 | 251 | 45 |
| 1974-06-21 | vs KCA | 67 | W 5-4 | 36-31 | 1 | 6,577 | Dave Hamilton | Bruce Dal Canton | Darold Knowles | Joe Hoerner | Rollie Fingers | 301 | 255 | 46 |
| 1974-06-22 | vs KCA | 68 | W 3-2 | 37-31 | 1 | 8,705 | Ken Holtzman | Paul Splittorff | Ken Holtzman | Paul Splittorff | | 304 | 257 | 47 |
| 1974-06-23 | vs KCA | 69 | L 1-4 | 37-32 | 1 | 9,891 | Glenn Abbott | Lindy McDaniel | Lindy McDaniel | Glenn Abbott | | 305 | 261 | 44 |
| 1974-06-24 | vs CAL | 70 | W 11-3 | 38-32 | 1 | 4,978 | Vida Blue | Dick Lange | Vida Blue | Dick Lange | | 316 | 264 | 52 |
| 1974-06-25 | vs CAL | 71 | W 6-1 | 39-32 | 1 | 4,344 | Catfish Hunter | Frank Tanana | Catfish Hunter | Frank Tanana | | 322 | 265 | 57 |
| 1974-06-26 | vs CAL | 72 | W 5-0 | 40-32 | 1 | 5,851 | Dave Hamilton | Bill Stoneman | Dave Hamilton | Bill Stoneman | | 327 | 265 | 62 |
| 1974-06-27 | @ KCA | 73 | L 4-5 | 40-33 | 1 | 24,894 | Ken Holtzman | Lindy McDaniel | Marty Pattin | Ken Holtzman | | 331 | 270 | 61 |
| 1974-06-28 | @ KCA | 74 | W 7-1 | 41-33 | 1 | 32,400 | Glenn Abbott | Nelson Briles | Glenn Abbott | Nelson Briles | | 338 | 271 | 67 |
| 1974-06-29 | @ KCA | 75 | L 0-2 | 41-34 | 1 | 39,474 | Vida Blue | Steve Busby | Steve Busby | Vida Blue | | 338 | 273 | 65 |
| 1974-06-30 | @ KCA | 76 | L 7-8 | 41-35 | 1 | 32,094 | Catfish Hunter | Al Fitzmorris | Gene Garber | Darold Knowles | | 345 | 281 | 64 |
| 1974-07-01 | @ CAL | 77 | W 5-3 | 42-35 | 1 | 16,405 | Dave Hamilton | Nolan Ryan | Rollie Fingers | Nolan Ryan | | 350 | 284 | 66 |
| 1974-07-02 | @ CAL | 78 | W 7-5 | 43-35 | 1 | 9,533 | Ken Holtzman | Frank Tanana | Ken Holtzman | Frank Tanana | Paul Lindblad | 357 | 289 | 68 |
| 1974-07-03 | @ CAL | 79 | W 3-2 | 44-35 | 1 | 9,979 | Glenn Abbott | Andy Hassler | Glenn Abbott | Andy Hassler | | 360 | 291 | 69 |
| 1974-07-04 | @ CAL | 80 | W 9-4 | 45-35 | 1 | 41,760 | Vida Blue | Dick Lange | Vida Blue | Dick Lange | | 369 | 295 | 74 |
| 1974-07-05 | vs BAL | 81 | W 6-0 | 46-35 | 1 | 9,671 | Catfish Hunter | Mike Cuellar | Catfish Hunter | Mike Cuellar | | 375 | 295 | 80 |
| 1974-07-06 | vs BAL | 82 | L 0-3 | 46-36 | 1 | 32,319 | Dave Hamilton | Ross Grimsley | Ross Grimsley | Dave Hamilton | | 375 | 298 | 77 |
| 1974-07-07 | vs BAL | 83 | L 1-4 | 46-37 | 1 | 10,181 | Ken Holtzman | Dave McNally | Dave McNally | Ken Holtzman | | 376 | 302 | 74 |
| 1974-07-08 | vs CLE | 84 | W 4-3 | 47-37 | 1 | 47,582 | Vida Blue | Gaylord Perry | Vida Blue | Gaylord Perry | | 380 | 305 | 75 |
| 1974-07-09 | vs CLE | 85 | W 7-0 | 48-37 | 1 | 6,655 | Catfish Hunter | Steve Arlin | Catfish Hunter | Steve Arlin | | 387 | 305 | 82 |
| 1974-07-12 | @ NYA | 86 | L 0-3 | 48-38 | 1 | 29,332 | Ken Holtzman | Pat Dobson | Pat Dobson | Ken Holtzman | | 387 | 308 | 79 |
| 1974-07-13 | @ NYA | 87 | L 6-12 | 48-39 | 1 | 24,204 | Vida Blue | Dick Tidrow | Dick Tidrow | Vida Blue | Sparky Lyle | 393 | 320 | 73 |
| 1974-07-14 | @ NYA | 88 | W 7-3 | 50-39 | 1 | 0 | Catfish Hunter | Dave Pagan | Catfish Hunter | Cecil Upshaw | Rollie Fingers | 400 | 323 | 77 |
| 1974-07-14 | @ NYA | 89 | W 6-1 | 50-39 | 1 | 43,799 | Dave Hamilton | Sam McDowell | Dave Hamilton | Sam McDowell | Paul Lindblad | 406 | 324 | 82 |
| 1974-07-15 | @ BAL | 90 | W 6-4 | 51-39 | 1 | 15,510 | Glenn Abbott | Wayne Garland | Blue Moon Odom | Wayne Garland | | 412 | 328 | 84 |
| 1974-07-16 | @ BAL | 91 | W 4-3 | 52-39 | 1 | 18,429 | Ken Holtzman | Doyle Alexander | Ken Holtzman | Doyle Alexander | Rollie Fingers | 416 | 331 | 85 |
| 1974-07-17 | @ BAL | 92 | W 2-0 | 53-39 | 1 | 22,607 | Vida Blue | Mike Cuellar | Vida Blue | Mike Cuellar | Rollie Fingers | 418 | 331 | 87 |
| 1974-07-18 | @ CLE | 93 | W 3-2 | 54-39 | 1 | 41,848 | Catfish Hunter | Gaylord Perry | Catfish Hunter | Gaylord Perry | | 421 | 333 | 88 |
| 1974-07-19 | @ CLE | 94 | L 0-4 | 54-40 | 1 | 24,302 | Dave Hamilton | Dick Bosman | Dick Bosman | Dave Hamilton | | 421 | 337 | 84 |
| 1974-07-20 | @ CLE | 95 | L 9-10 | 54-41 | 1 | 19,126 | Ken Holtzman | Fritz Peterson | Tom Hilgendorf | Rollie Fingers | | 430 | 347 | 83 |
| 1974-07-21 | @ CLE | 96 | W 6-3 | 55-41 | 1 | 40,368 | Vida Blue | Jim Perry | Vida Blue | Jim Perry | Paul Lindblad | 436 | 350 | 86 |
| 1974-07-25 | vs MIN | 97 | W 5-1 | 56-41 | 1 | 5,606 | Vida Blue | Joe Decker | Vida Blue | Joe Decker | | 441 | 351 | 90 |
| 1974-07-26 | vs MIN | 98 | W 5-3 | 57-41 | 1 | 9,059 | Glenn Abbott | Bert Blyleven | Glenn Abbott | Bert Blyleven | Rollie Fingers | 446 | 354 | 92 |
| 1974-07-27 | vs MIN | 99 | L 1-6 | 57-42 | 1 | 9,523 | Catfish Hunter | Ray Corbin | Ray Corbin | Catfish Hunter | | 447 | 360 | 87 |
| 1974-07-28 | vs CHA | 100 | W 7-2 | 59-42 | 1 | 0 | Ken Holtzman | Stan Bahnsen | Ken Holtzman | Stan Bahnsen | | 454 | 362 | 92 |
| 1974-07-28 | vs CHA | 101 | W 3-2 | 59-42 | 1 | 24,317 | Dave Hamilton | Lloyd Allen | Paul Lindblad | Lloyd Allen | Rollie Fingers | 457 | 364 | 93 |
| 1974-07-29 | vs CHA | 102 | W 11-9 | 60-42 | 1 | 44,279 | Vida Blue | Wilbur Wood | Paul Lindblad | Terry Forster | | 468 | 373 | 95 |
| 1974-07-30 | vs TEX | 103 | W 11-3 | 61-42 | 1 | 5,949 | Glenn Abbott | Jim Bibby | Glenn Abbott | Jim Bibby | | 479 | 376 | 103 |
| 1974-07-31 | vs TEX | 104 | L 6-7 | 61-43 | 1 | 8,886 | Catfish Hunter | Steve Hargan | Steve Foucault | Paul Lindblad | | 485 | 383 | 102 |
| 1974-08-01 | @ CHA | 105 | L 3-7 | 61-44 | 1 | 20,530 | Ken Holtzman | Stan Bahnsen | Stan Bahnsen | Ken Holtzman | | 488 | 390 | 98 |
| 1974-08-02 | @ CHA | 106 | W 3-2 | 62-44 | 1 | 32,056 | Vida Blue | Wilbur Wood | Vida Blue | Wilbur Wood | | 491 | 392 | 99 |
| 1974-08-04 | @ MIN | 107 | W 10-4 | 63-45 | 1 | 0 | Catfish Hunter | Joe Decker | Catfish Hunter | Joe Decker | | 501 | 396 | 105 |
| 1974-08-04 | @ MIN | 108 | L 1-2 | 63-45 | 1 | 34,145 | Glenn Abbott | Bill Butler | Bill Butler | Glenn Abbott | | 502 | 398 | 104 |
| 1974-08-05 | @ MIN | 109 | W 2-1 | 64-46 | 1 | 0 | Ken Holtzman | Bert Blyleven | Ken Holtzman | Bert Blyleven | Rollie Fingers | 504 | 399 | 105 |
| 1974-08-05 | @ MIN | 110 | L 3-4 | 64-46 | 1 | 23,316 | Dave Hamilton | Bill Hands | Bill Hands | Dave Hamilton | Bill Campbell | 507 | 403 | 104 |
| 1974-08-06 | @ TEX | 111 | L 0-1 | 64-47 | 1 | 22,882 | Blue Moon Odom | Fergie Jenkins | Fergie Jenkins | Blue Moon Odom | | 507 | 404 | 103 |
| 1974-08-07 | @ TEX | 112 | W 8-4 | 65-47 | 1 | 25,277 | Darold Knowles | Jim Bibby | Darold Knowles | Jim Bibby | Rollie Fingers | 515 | 408 | 107 |
| 1974-08-08 | @ TEX | 113 | W 10-2 | 66-47 | 1 | 14,727 | Catfish Hunter | David Clyde | Catfish Hunter | David Clyde | | 525 | 410 | 115 |
| 1974-08-09 | vs BOS | 114 | L 2-6 | 66-48 | 1 | 12,214 | Ken Holtzman | Bill Lee | Bill Lee | Ken Holtzman | | 527 | 416 | 111 |
| 1974-08-10 | vs BOS | 115 | W 5-3 | 67-48 | 1 | 11,414 | Vida Blue | Reggie Cleveland | Vida Blue | Reggie Cleveland | | 532 | 419 | 113 |
| 1974-08-11 | vs BOS | 116 | L 1-2 | 67-49 | 1 | 14,291 | Glenn Abbott | Juan Marichal | Juan Marichal | Glenn Abbott | | 533 | 421 | 112 |
| 1974-08-12 | vs NYA | 117 | W 3-2 | 68-49 | 1 | 27,137 | Catfish Hunter | Pat Dobson | Catfish Hunter | Pat Dobson | | 536 | 423 | 113 |
| 1974-08-13 | vs NYA | 118 | W 6-1 | 69-49 | 1 | 6,255 | Ken Holtzman | Doc Medich | Ken Holtzman | Doc Medich | | 542 | 424 | 118 |
| 1974-08-14 | vs NYA | 119 | L 1-4 | 69-50 | 1 | 7,676 | Vida Blue | Rudy May | Rudy May | Vida Blue | | 543 | 428 | 115 |
| 1974-08-16 | vs DET | 120 | L 3-5 | 69-51 | 1 | 6,813 | Catfish Hunter | Mickey Lolich | Mickey Lolich | Catfish Hunter | | 546 | 433 | 113 |
| 1974-08-17 | vs DET | 121 | L 3-4 | 69-52 | 1 | 10,600 | Glenn Abbott | Lerrin LaGrow | John Hiller | Glenn Abbott | | 549 | 437 | 112 |
| 1974-08-18 | vs DET | 122 | W 13-3 | 70-52 | 1 | 9,327 | Ken Holtzman | Joe Coleman | Ken Holtzman | Joe Coleman | Rollie Fingers | 562 | 440 | 122 |
| 1974-08-19 | vs MIL | 123 | L 0-1 | 70-53 | 1 | 33,213 | Vida Blue | Bill Champion | Bill Champion | Vida Blue | Tom Murphy | 562 | 441 | 121 |
| 1974-08-20 | vs MIL | 124 | W 7-1 | 71-53 | 1 | 4,737 | Catfish Hunter | Eduardo Rodriguez | Catfish Hunter | Eduardo Rodriguez | | 569 | 442 | 127 |
| 1974-08-21 | vs MIL | 125 | L 3-5 | 71-54 | 1 | 5,240 | Blue Moon Odom | Kevin Kobel | Kevin Kobel | Blue Moon Odom | | 572 | 447 | 125 |
| 1974-08-23 | @ BOS | 126 | L 0-3 | 71-55 | 1 | 35,866 | Vida Blue | Luis Tiant | Luis Tiant | Vida Blue | | 572 | 450 | 122 |
| 1974-08-24 | @ BOS | 127 | W 4-1 | 72-55 | 1 | 34,693 | Catfish Hunter | Bill Lee | Catfish Hunter | Diego Segui | | 576 | 451 | 125 |
| 1974-08-25 | @ BOS | 128 | W 7-0 | 73-55 | 1 | 34,293 | Ken Holtzman | Roger Moret | Ken Holtzman | Roger Moret | | 583 | 451 | 132 |
| 1974-08-26 | @ MIL | 129 | L 1-2 | 73-56 | 1 | 9,244 | Blue Moon Odom | Bill Champion | Bill Champion | Blue Moon Odom | Tom Murphy | 584 | 453 | 131 |
| 1974-08-27 | @ MIL | 130 | W 3-2 | 74-56 | 1 | 14,363 | Vida Blue | Jim Slaton | Rollie Fingers | Tom Murphy | | 587 | 455 | 132 |
| 1974-08-28 | @ MIL | 131 | W 3-1 | 75-56 | 1 | 11,059 | Catfish Hunter | Jim Colborn | Catfish Hunter | Jim Colborn | Rollie Fingers | 590 | 456 | 134 |
| 1974-08-30 | @ DET | 132 | W 10-5 | 76-56 | 1 | 18,010 | Ken Holtzman | Lerrin LaGrow | Ken Holtzman | Lerrin LaGrow | Blue Moon Odom | 600 | 461 | 139 |
| 1974-08-31 | @ DET | 133 | L 3-7 | 76-57 | 1 | 22,247 | Vida Blue | Joe Coleman | Joe Coleman | Vida Blue | | 603 | 468 | 135 |
| 1974-09-01 | @ DET | 134 | W 5-3 | 77-57 | 1 | 17,235 | Catfish Hunter | Mickey Lolich | Catfish Hunter | Mickey Lolich | Rollie Fingers | 608 | 471 | 137 |
| 1974-09-02 | vs CAL | 135 | W 6-4 | 78-57 | 1 | 25,640 | Glenn Abbott | Frank Tanana | Glenn Abbott | Frank Tanana | Rollie Fingers | 614 | 475 | 139 |
| 1974-09-03 | vs CAL | 136 | W 7-0 | 79-57 | 1 | 4,341 | Ken Holtzman | Nolan Ryan | Ken Holtzman | Nolan Ryan | | 621 | 475 | 146 |
| 1974-09-04 | vs CAL | 137 | L 2-5 | 79-58 | 1 | 3,218 | Vida Blue | Andy Hassler | Andy Hassler | Vida Blue | | 623 | 480 | 143 |
| 1974-09-05 | vs TEX | 138 | W 3-0 | 80-58 | 1 | 2,876 | Catfish Hunter | Jackie Brown | Catfish Hunter | Jackie Brown | | 626 | 480 | 146 |
| 1974-09-06 | vs TEX | 139 | L 4-5 | 80-59 | 1 | 9,781 | Dave Hamilton | Jim Bibby | Steve Foucault | Rollie Fingers | | 630 | 485 | 145 |
| 1974-09-07 | vs TEX | 140 | L 2-8 | 80-60 | 1 | 5,847 | Glenn Abbott | Steve Hargan | Steve Hargan | Glenn Abbott | | 632 | 493 | 139 |
| 1974-09-08 | vs TEX | 141 | L 1-5 | 80-61 | 1 | 8,984 | Ken Holtzman | Fergie Jenkins | Fergie Jenkins | Ken Holtzman | | 633 | 498 | 135 |
| 1974-09-09 | vs KCA | 142 | W 3-0 | 82-61 | 1 | 0 | Vida Blue | Steve Busby | Vida Blue | Steve Busby | | 636 | 498 | 138 |
| 1974-09-09 | vs KCA | 143 | W 7-0 | 82-61 | 1 | 46,780 | Catfish Hunter | Paul Splittorff | Catfish Hunter | Paul Splittorff | | 643 | 498 | 145 |
| 1974-09-11 | @ MIN | 144 | L 3-5 | 82-62 | 1 | 3,982 | Glenn Abbott | Joe Decker | Bill Campbell | Darold Knowles | | 646 | 503 | 143 |
| 1974-09-12 | @ MIN | 145 | W 2-1 | 83-62 | 1 | 4,743 | Ken Holtzman | Bert Blyleven | Ken Holtzman | Bert Blyleven | | 648 | 504 | 144 |
| 1974-09-13 | @ TEX | 146 | L 1-3 | 83-63 | 1 | 21,411 | Catfish Hunter | Fergie Jenkins | Fergie Jenkins | Catfish Hunter | | 649 | 507 | 142 |
| 1974-09-14 | @ TEX | 147 | L 3-8 | 83-64 | 1 | 28,140 | Vida Blue | Jackie Brown | Jackie Brown | Vida Blue | | 652 | 515 | 137 |
| 1974-09-15 | @ TEX | 148 | W 4-1 | 84-64 | 1 | 19,533 | Glenn Abbott | Jim Bibby | Rollie Fingers | Jim Bibby | | 656 | 516 | 140 |
| 1974-09-17 | @ KCA | 149 | L 1-2 | 84-65 | 1 | 14,412 | Catfish Hunter | Steve Busby | Steve Busby | Catfish Hunter | | 657 | 518 | 139 |
| 1974-09-18 | @ KCA | 150 | W 5-4 | 85-65 | 1 | 14,976 | Ken Holtzman | Paul Splittorff | Ken Holtzman | Paul Splittorff | Rollie Fingers | 662 | 522 | 140 |
| 1974-09-19 | @ KCA | 151 | L 3-4 | 85-66 | 1 | 14,218 | Vida Blue | Nelson Briles | Doug Bird | Rollie Fingers | | 665 | 526 | 139 |
| 1974-09-20 | @ CHA | 152 | L 0-2 | 85-67 | 1 | 9,129 | Glenn Abbott | Bart Johnson | Bart Johnson | Glenn Abbott | Terry Forster | 665 | 528 | 137 |
| 1974-09-21 | @ CHA | 153 | W 3-2 | 86-67 | 1 | 8,155 | Catfish Hunter | Wilbur Wood | Catfish Hunter | Wilbur Wood | | 668 | 530 | 138 |
| 1974-09-22 | @ CHA | 154 | L 1-3 | 86-68 | 1 | 9,471 | Ken Holtzman | Jim Kaat | Jim Kaat | Ken Holtzman | | 669 | 533 | 136 |
| 1974-09-24 | vs MIN | 155 | W 5-1 | 87-68 | 1 | 4,047 | Vida Blue | Joe Decker | Vida Blue | Joe Decker | | 674 | 534 | 140 |
| 1974-09-25 | vs MIN | 156 | L 0-1 | 87-69 | 1 | 3,211 | Glenn Abbott | Bert Blyleven | Bert Blyleven | Glenn Abbott | | 674 | 535 | 139 |
| 1974-09-26 | vs MIN | 157 | W 2-1 | 88-69 | 1 | 3,461 | Catfish Hunter | Dave Goltz | Catfish Hunter | Dave Goltz | | 676 | 536 | 140 |
| 1974-09-27 | vs CHA | 158 | L 2-3 | 88-70 | 1 | 7,177 | Ken Holtzman | Stan Bahnsen | Stan Bahnsen | Ken Holtzman | Terry Forster | 678 | 539 | 139 |
| 1974-09-28 | vs CHA | 159 | W 6-5 | 89-70 | 1 | 21,560 | Vida Blue | Jack Kucek | Vida Blue | Jack Kucek | Paul Lindblad | 684 | 544 | 140 |
| 1974-09-29 | vs CHA | 160 | W 3-2 | 90-70 | 1 | 6,448 | Glenn Abbott | Jim Otten | Dave Hamilton | Jim Otten | Darold Knowles | 687 | 546 | 141 |
| 1974-10-01 | @ CAL | 161 | L 0-2 | 90-71 | 1 | 5,058 | Catfish Hunter | Frank Tanana | Frank Tanana | Ken Holtzman | | 687 | 548 | 139 |
| 1974-10-02 | @ CAL | 162 | L 2-3 | 90-72 | 1 | 6,861 | Vida Blue | Chuck Dobson | Chuck Dobson | Paul Lindblad | | 689 | 551 | 138 |