| 1973-04-06 | vs NYA | 1 | W 15-5 | 1-0 | 2 | 32,882 | Luis Tiant | Mel Stottlemyre | Luis Tiant | Mel Stottlemyre | | 15 | 5 | 10 |
| 1973-04-07 | vs NYA | 2 | W 10-5 | 2-0 | 2 | 19,236 | Marty Pattin | Steve Kline | Marty Pattin | Steve Kline | Bob Veale | 25 | 10 | 15 |
| 1973-04-08 | vs NYA | 3 | W 4-3 | 3-0 | 2 | 12,754 | John Curtis | Doc Medich | Bob Veale | Sparky Lyle | | 29 | 13 | 16 |
| 1973-04-14 | @ NYA | 4 | W 3-1 | 4-0 | 1 | 13,037 | Luis Tiant | Fritz Peterson | Luis Tiant | Fritz Peterson | Bob Veale | 32 | 14 | 18 |
| 1973-04-15 | @ NYA | 5 | L 2-6 | 4-1 | 1 | 35,700 | John Curtis | Mel Stottlemyre | Mel Stottlemyre | John Curtis | | 34 | 20 | 14 |
| 1973-04-16 | vs DET | 6 | L 7-9 | 4-2 | 2 | 29,006 | Marty Pattin | Mickey Lolich | Mickey Lolich | Marty Pattin | Lerrin LaGrow | 41 | 29 | 12 |
| 1973-04-17 | vs DET | 7 | L 3-6 | 4-3 | 2 | 11,298 | Lynn McGlothen | Joe Coleman | Joe Coleman | Lynn McGlothen | John Hiller | 44 | 35 | 9 |
| 1973-04-18 | vs DET | 8 | L 1-7 | 4-4 | 3 | 15,971 | Luis Tiant | Jim Perry | Jim Perry | Luis Tiant | | 45 | 42 | 3 |
| 1973-04-19 | vs DET | 9 | L 7-11 | 4-5 | 4 | 13,572 | John Curtis | Woodie Fryman | Woodie Fryman | John Curtis | Tom Timmermann | 52 | 53 | -1 |
| 1973-04-20 | @ CLE | 10 | L 2-3 | 4-6 | 6 | 12,185 | Marty Pattin | Gaylord Perry | Gaylord Perry | Marty Pattin | | 54 | 56 | -2 |
| 1973-04-21 | @ CLE | 11 | W 11-5 | 5-6 | 4 | 9,202 | Lynn McGlothen | Dick Tidrow | Lynn McGlothen | Dick Tidrow | Bill Lee | 65 | 61 | 4 |
| 1973-04-22 | @ CLE | 12 | L 7-8 | 6-7 | 4 | 0 | Luis Tiant | Brent Strom | Jerry Johnson | Sonny Siebert | | 72 | 69 | 3 |
| 1973-04-22 | @ CLE | 13 | W 5-2 | 6-7 | 4 | 8,145 | Roger Moret | Steve Dunning | Roger Moret | Steve Dunning | Bob Veale | 77 | 71 | 6 |
| 1973-04-24 | vs MIN | 14 | L 4-6 | 6-8 | 4 | 10,859 | Marty Pattin | Dick Woodson | Dick Woodson | Marty Pattin | Ken Sanders | 81 | 77 | 4 |
| 1973-04-25 | vs MIN | 15 | W 4-3 | 7-8 | 4 | 9,529 | Lynn McGlothen | Bill Hands | Bill Lee | Ray Corbin | Bobby Bolin | 85 | 80 | 5 |
| 1973-04-28 | vs CHA | 16 | L 1-2 | 7-9 | 4 | 18,888 | Luis Tiant | Stan Bahnsen | Stan Bahnsen | Luis Tiant | Terry Forster | 86 | 82 | 4 |
| 1973-04-29 | vs CHA | 17 | L 0-5 | 7-10 | 6 | 11,617 | Marty Pattin | Wilbur Wood | Wilbur Wood | Marty Pattin | | 86 | 87 | -1 |
| 1973-05-01 | vs TEX | 18 | L 6-7 | 7-11 | 6 | 8,616 | Bill Lee | Rich Hand | Steve Foucault | Lynn McGlothen | | 92 | 94 | -2 |
| 1973-05-02 | vs TEX | 19 | W 6-2 | 8-11 | 6 | 8,247 | Luis Tiant | Pete Broberg | Luis Tiant | Pete Broberg | | 98 | 96 | 2 |
| 1973-05-04 | @ MIN | 20 | L 6-9 | 8-12 | 6 | 7,285 | Marty Pattin | Jim Kaat | Jim Kaat | Marty Pattin | Ken Sanders | 104 | 105 | -1 |
| 1973-05-05 | @ MIN | 21 | W 5-1 | 9-12 | 6 | 6,996 | Bill Lee | Bert Blyleven | Bill Lee | Bert Blyleven | Bob Veale | 109 | 106 | 3 |
| 1973-05-06 | @ MIN | 22 | L 3-10 | 9-13 | 6 | 7,431 | Luis Tiant | Bill Hands | Bill Hands | Luis Tiant | | 112 | 116 | -4 |
| 1973-05-07 | @ CHA | 23 | W 4-1 | 10-13 | 4 | 6,489 | John Curtis | Stan Bahnsen | John Curtis | Stan Bahnsen | | 116 | 117 | -1 |
| 1973-05-08 | @ CHA | 24 | L 0-1 | 10-14 | 6 | 9,234 | Marty Pattin | Eddie Fisher | Eddie Fisher | Marty Pattin | Terry Forster | 116 | 118 | -2 |
| 1973-05-10 | vs CLE | 25 | W 4-3 | 11-14 | 6 | 8,640 | Bill Lee | Dick Tidrow | Bill Lee | Jerry Johnson | | 120 | 121 | -1 |
| 1973-05-11 | vs CLE | 26 | W 4-2 | 12-14 | 3 | 12,803 | Luis Tiant | Brent Strom | Luis Tiant | Brent Strom | | 124 | 123 | 1 |
| 1973-05-12 | vs CLE | 27 | L 2-10 | 12-15 | 6 | 15,510 | John Curtis | Gaylord Perry | Gaylord Perry | John Curtis | | 126 | 133 | -7 |
| 1973-05-13 | vs CLE | 28 | W 8-3 | 13-15 | 4 | 13,711 | Marty Pattin | Milt Wilcox | Marty Pattin | Ray Lamb | | 134 | 136 | -2 |
| 1973-05-14 | vs BAL | 29 | W 1-0 | 14-15 | 1 | 13,020 | Bill Lee | Doyle Alexander | Bobby Bolin | Bob Reynolds | | 135 | 136 | -1 |
| 1973-05-16 | @ DET | 30 | L 5-6 | 14-16 | 4 | 10,030 | Luis Tiant | Mickey Lolich | John Hiller | Luis Tiant | | 140 | 142 | -2 |
| 1973-05-17 | @ DET | 31 | L 0-1 | 14-17 | 5 | 9,236 | John Curtis | Jim Perry | Jim Perry | John Curtis | | 140 | 143 | -3 |
| 1973-05-18 | @ DET | 32 | L 4-5 | 14-18 | 5 | 21,845 | Marty Pattin | Woodie Fryman | Tom Timmermann | Marty Pattin | John Hiller | 144 | 148 | -4 |
| 1973-05-19 | @ BAL | 33 | L 1-3 | 14-19 | 6 | 12,801 | Bill Lee | Doyle Alexander | Doyle Alexander | Bill Lee | | 145 | 151 | -6 |
| 1973-05-21 | @ BAL | 34 | W 4-1 | 15-19 | 5 | 7,105 | Luis Tiant | Jim Palmer | Luis Tiant | Jim Palmer | | 149 | 152 | -3 |
| 1973-05-22 | vs MIL | 35 | L 2-4 | 15-20 | 6 | 10,554 | John Curtis | Jim Colborn | Jim Colborn | John Curtis | Frank Linzy | 151 | 156 | -5 |
| 1973-05-23 | vs MIL | 36 | W 5-3 | 16-20 | 5 | 10,464 | Marty Pattin | Jerry Bell | Marty Pattin | Jerry Bell | Bob Veale | 156 | 159 | -3 |
| 1973-05-24 | vs MIL | 37 | W 10-1 | 17-20 | 5 | 8,416 | Bill Lee | Bill Champion | Bill Lee | Bill Champion | | 166 | 160 | 6 |
| 1973-05-27 | @ KCA | 38 | L 3-13 | 18-21 | 5 | 0 | Luis Tiant | Gene Garber | Gene Garber | Luis Tiant | | 169 | 173 | -4 |
| 1973-05-27 | @ KCA | 39 | W 7-2 | 18-21 | 5 | 23,952 | John Curtis | Steve Busby | John Curtis | Steve Busby | | 176 | 175 | 1 |
| 1973-05-28 | @ KCA | 40 | L 4-5 | 18-22 | 5 | 10,176 | Marty Pattin | Dick Drago | Doug Bird | Bob Veale | | 180 | 180 | 0 |
| 1973-05-29 | vs CAL | 41 | W 2-1 | 19-22 | 4 | 12,691 | Bill Lee | Nolan Ryan | Bill Lee | Nolan Ryan | Bobby Bolin | 182 | 181 | 1 |
| 1973-05-30 | vs CAL | 42 | W 2-1 | 20-22 | 4 | 11,809 | Luis Tiant | Clyde Wright | Luis Tiant | Clyde Wright | | 184 | 182 | 2 |
| 1973-05-31 | vs CAL | 43 | L 6-7 | 20-23 | 4 | 10,600 | John Curtis | Rudy May | Rich Hand | Bobby Bolin | Dave Sells | 190 | 189 | 1 |
| 1973-06-01 | vs OAK | 44 | W 6-2 | 21-23 | 3 | 28,053 | Marty Pattin | Dave Hamilton | Marty Pattin | Dave Hamilton | | 196 | 191 | 5 |
| 1973-06-02 | vs OAK | 45 | L 1-3 | 21-24 | 4 | 27,692 | Bill Lee | Catfish Hunter | Catfish Hunter | Bill Lee | | 197 | 194 | 3 |
| 1973-06-03 | vs OAK | 46 | L 1-12 | 21-25 | 5 | 31,497 | Luis Tiant | Vida Blue | Vida Blue | Luis Tiant | Horacio Pina | 198 | 206 | -8 |
| 1973-06-04 | vs KCA | 47 | W 9-3 | 22-25 | 5 | 10,653 | John Curtis | Gene Garber | John Curtis | Gene Garber | Don Newhauser | 207 | 209 | -2 |
| 1973-06-05 | vs KCA | 48 | W 9-2 | 23-25 | 5 | 10,966 | Marty Pattin | Dick Drago | Marty Pattin | Dick Drago | | 216 | 211 | 5 |
| 1973-06-06 | vs KCA | 49 | W 5-4 | 24-25 | 4 | 12,488 | Bill Lee | Ken Wright | Bill Lee | Doug Bird | | 221 | 215 | 6 |
| 1973-06-08 | @ TEX | 50 | L 2-5 | 24-26 | 5 | 8,231 | John Curtis | Pete Broberg | Pete Broberg | John Curtis | Bill Gogolewski | 223 | 220 | 3 |
| 1973-06-09 | @ TEX | 51 | W 12-1 | 25-26 | 5 | 12,624 | Marty Pattin | Steve Dunning | Marty Pattin | Steve Dunning | Bob Veale | 235 | 221 | 14 |
| 1973-06-10 | @ TEX | 52 | W 10-1 | 26-26 | 4 | 9,729 | Bill Lee | Sonny Siebert | Bill Lee | Sonny Siebert | | 245 | 222 | 23 |
| 1973-06-12 | @ CAL | 53 | W 6-5 | 27-26 | 5 | 11,120 | Luis Tiant | Nolan Ryan | Luis Tiant | Nolan Ryan | Bobby Bolin | 251 | 227 | 24 |
| 1973-06-13 | @ CAL | 54 | L 5-7 | 27-27 | 5 | 8,775 | Ray Culp | Clyde Wright | Clyde Wright | Ray Culp | Dave Sells | 256 | 234 | 22 |
| 1973-06-14 | @ CAL | 55 | L 3-5 | 27-28 | 5 | 10,216 | John Curtis | Rudy May | Rudy May | John Curtis | Dave Sells | 259 | 239 | 20 |
| 1973-06-15 | @ OAK | 56 | L 3-8 | 27-29 | 5 | 8,196 | Marty Pattin | Catfish Hunter | Catfish Hunter | Marty Pattin | | 262 | 247 | 15 |
| 1973-06-16 | @ OAK | 57 | L 3-4 | 27-30 | 5 | 8,935 | Bill Lee | Vida Blue | Darold Knowles | Bobby Bolin | | 265 | 251 | 14 |
| 1973-06-17 | @ OAK | 58 | W 4-2 | 28-30 | 5 | 15,172 | Luis Tiant | Ken Holtzman | Luis Tiant | Ken Holtzman | | 269 | 253 | 16 |
| 1973-06-18 | @ MIL | 59 | L 3-8 | 28-31 | 5 | 22,796 | Ray Culp | Jim Colborn | Jim Colborn | Ray Culp | | 272 | 261 | 11 |
| 1973-06-19 | @ MIL | 60 | W 8-4 | 30-31 | 5 | 0 | Marty Pattin | Jim Slaton | Marty Pattin | Frank Linzy | | 280 | 265 | 15 |
| 1973-06-19 | @ MIL | 61 | W 4-1 | 30-31 | 5 | 37,836 | John Curtis | Chris Short | John Curtis | Skip Lockwood | Bob Veale | 284 | 266 | 18 |
| 1973-06-20 | @ MIL | 62 | W 3-2 | 31-31 | 5 | 12,747 | Bill Lee | Bill Parsons | Bill Lee | Bill Parsons | | 287 | 268 | 19 |
| 1973-06-21 | vs BAL | 63 | L 3-6 | 31-32 | 5 | 21,876 | Luis Tiant | Jim Palmer | Bob Reynolds | Luis Tiant | Grant Jackson | 290 | 274 | 16 |
| 1973-06-23 | vs BAL | 64 | W 5-1 | 32-33 | 4 | 0 | Ray Culp | Dave McNally | Ray Culp | Dave McNally | Bobby Bolin | 295 | 275 | 20 |
| 1973-06-23 | vs BAL | 65 | L 1-2 | 32-33 | 4 | 30,676 | Marty Pattin | Jesse Jefferson | Jesse Jefferson | Marty Pattin | | 296 | 277 | 19 |
| 1973-06-24 | vs BAL | 66 | W 1-0 | 33-33 | 4 | 26,244 | John Curtis | Doyle Alexander | John Curtis | Doyle Alexander | | 297 | 277 | 20 |
| 1973-06-25 | vs DET | 67 | W 2-1 | 34-33 | 4 | 20,837 | Bill Lee | Jim Perry | Bill Lee | Jim Perry | | 299 | 278 | 21 |
| 1973-06-26 | vs DET | 68 | L 1-4 | 34-34 | 4 | 20,152 | Luis Tiant | Mike Strahler | Mike Strahler | Luis Tiant | John Hiller | 300 | 282 | 18 |
| 1973-06-28 | vs CLE | 69 | L 2-4 | 35-35 | 4 | 0 | Ray Culp | Dick Tidrow | Dick Tidrow | Ray Culp | Tom Timmermann | 302 | 286 | 16 |
| 1973-06-28 | vs CLE | 70 | W 16-7 | 35-35 | 4 | 15,139 | Marty Pattin | Dick Bosman | Marty Pattin | Dick Bosman | Roger Moret | 318 | 293 | 25 |
| 1973-07-01 | vs MIL | 71 | L 5-9 | 36-36 | 5 | 0 | Bill Lee | Jim Colborn | Jim Colborn | Bill Lee | Frank Linzy | 323 | 302 | 21 |
| 1973-07-01 | vs MIL | 72 | W 4-2 | 36-36 | 5 | 25,754 | Luis Tiant | Jim Slaton | Luis Tiant | Jim Slaton | | 327 | 304 | 23 |
| 1973-07-02 | @ NYA | 73 | W 1-0 | 37-36 | 5 | 23,453 | John Curtis | Fritz Peterson | John Curtis | Fritz Peterson | | 328 | 304 | 24 |
| 1973-07-03 | @ NYA | 74 | L 1-3 | 37-37 | 4 | 14,499 | Marty Pattin | Sam McDowell | Sam McDowell | Marty Pattin | Sparky Lyle | 329 | 307 | 22 |
| 1973-07-04 | @ NYA | 75 | W 2-1 | 39-37 | 3 | 0 | Ray Culp | Mel Stottlemyre | Ray Culp | Sparky Lyle | Bob Veale | 331 | 308 | 23 |
| 1973-07-04 | @ NYA | 76 | W 1-0 | 39-37 | 3 | 41,693 | Roger Moret | Doc Medich | Roger Moret | Doc Medich | | 332 | 308 | 24 |
| 1973-07-05 | @ NYA | 77 | W 9-4 | 40-37 | 3 | 12,744 | Bill Lee | Pat Dobson | Bill Lee | Pat Dobson | | 341 | 312 | 29 |
| 1973-07-06 | @ CHA | 78 | W 5-2 | 41-37 | 3 | 28,960 | Luis Tiant | Wilbur Wood | Luis Tiant | Wilbur Wood | Bob Veale | 346 | 314 | 32 |
| 1973-07-07 | @ CHA | 79 | W 7-3 | 42-37 | 3 | 35,681 | John Curtis | Stan Bahnsen | John Curtis | Stan Bahnsen | | 353 | 317 | 36 |
| 1973-07-08 | @ CHA | 80 | L 1-6 | 43-38 | 2 | 0 | Marty Pattin | Steve Stone | Steve Stone | Marty Pattin | Cy Acosta | 354 | 323 | 31 |
| 1973-07-08 | @ CHA | 81 | W 11-2 | 43-38 | 2 | 19,102 | Ray Culp | Bart Johnson | Roger Moret | Terry Forster | | 365 | 325 | 40 |
| 1973-07-09 | @ MIN | 82 | W 2-0 | 44-38 | 2 | 13,692 | Bill Lee | Joe Decker | Bill Lee | Joe Decker | | 367 | 325 | 42 |
| 1973-07-10 | @ MIN | 83 | W 2-1 | 45-38 | 1 | 11,907 | Luis Tiant | Jim Kaat | Luis Tiant | Jim Kaat | | 369 | 326 | 43 |
| 1973-07-11 | @ MIN | 84 | L 0-3 | 45-39 | 2 | 11,617 | John Curtis | Bert Blyleven | Bert Blyleven | John Curtis | | 369 | 329 | 40 |
| 1973-07-12 | vs TEX | 85 | W 5-2 | 46-39 | 2 | 31,896 | Marty Pattin | David Clyde | Marty Pattin | David Clyde | | 374 | 331 | 43 |
| 1973-07-13 | vs TEX | 86 | L 1-4 | 46-40 | 2 | 19,375 | Ray Culp | Jim Bibby | Jim Bibby | Ray Culp | | 375 | 335 | 40 |
| 1973-07-14 | vs TEX | 87 | W 6-5 | 47-40 | 2 | 13,253 | Bill Lee | Steve Dunning | Bobby Bolin | Jackie Brown | Bob Veale | 381 | 340 | 41 |
| 1973-07-15 | vs TEX | 88 | W 3-1 | 48-40 | 2 | 11,793 | Luis Tiant | Jim Merritt | Luis Tiant | Jim Merritt | | 384 | 341 | 43 |
| 1973-07-16 | vs CHA | 89 | W 9-8 | 49-40 | 2 | 20,772 | John Curtis | Bart Johnson | Bobby Bolin | Cy Acosta | | 393 | 349 | 44 |
| 1973-07-17 | vs CHA | 90 | L 4-8 | 49-42 | 3 | 25,517 | Marty Pattin | Wilbur Wood | Wilbur Wood | Marty Pattin | Terry Forster | 397 | 357 | 40 |
| 1973-07-17 | vs CHA | 91 | L 0-5 | 49-42 | 3 | 23,191 | Ray Culp | Stan Bahnsen | Stan Bahnsen | Ray Culp | | 397 | 362 | 35 |
| 1973-07-18 | vs CHA | 92 | W 6-1 | 50-42 | 3 | 15,809 | Bill Lee | Steve Stone | Bill Lee | Steve Stone | | 403 | 363 | 40 |
| 1973-07-19 | vs MIN | 93 | L 2-6 | 50-43 | 3 | 21,359 | Luis Tiant | Joe Decker | Joe Decker | Luis Tiant | | 405 | 369 | 36 |
| 1973-07-20 | vs MIN | 94 | W 5-0 | 51-43 | 3 | 22,996 | John Curtis | Bert Blyleven | John Curtis | Bert Blyleven | | 410 | 369 | 41 |
| 1973-07-21 | vs MIN | 95 | W 3-2 | 52-43 | 3 | 19,492 | Marty Pattin | Dick Woodson | Marty Pattin | Dick Woodson | Roger Moret | 413 | 371 | 42 |
| 1973-07-22 | vs MIN | 96 | L 7-10 | 52-44 | 3 | 28,656 | Bill Lee | Jim Kaat | Jim Kaat | Bill Lee | Ray Corbin | 420 | 381 | 39 |
| 1973-07-26 | @ DET | 97 | L 5-6 | 52-45 | 3 | 22,364 | Luis Tiant | Mickey Lolich | John Hiller | Bobby Bolin | | 425 | 387 | 38 |
| 1973-07-27 | @ DET | 98 | L 2-4 | 52-46 | 3 | 31,828 | Bill Lee | Jim Perry | John Hiller | Bill Lee | | 427 | 391 | 36 |
| 1973-07-28 | @ CLE | 99 | W 7-4 | 53-46 | 3 | 7,865 | John Curtis | Mike Kekich | John Curtis | Mike Kekich | Roger Moret | 434 | 395 | 39 |
| 1973-07-29 | @ CLE | 100 | L 2-8 | 53-48 | 3 | 0 | Marty Pattin | Gaylord Perry | Gaylord Perry | Marty Pattin | | 436 | 403 | 33 |
| 1973-07-29 | @ CLE | 101 | L 2-6 | 53-48 | 3 | 26,858 | Ray Culp | Tom Timmermann | Tom Timmermann | Ray Culp | | 438 | 409 | 29 |
| 1973-07-30 | vs NYA | 102 | W 4-3 | 54-48 | 3 | 31,700 | Luis Tiant | Fred Beene | Luis Tiant | Sparky Lyle | | 442 | 412 | 30 |
| 1973-07-31 | vs NYA | 103 | L 4-5 | 54-49 | 4 | 33,084 | Bill Lee | Pat Dobson | Lindy McDaniel | Bob Veale | | 446 | 417 | 29 |
| 1973-08-01 | vs NYA | 104 | W 3-2 | 55-49 | 4 | 30,689 | John Curtis | Mel Stottlemyre | John Curtis | Sparky Lyle | | 449 | 419 | 30 |
| 1973-08-02 | vs NYA | 105 | W 10-0 | 56-49 | 4 | 30,393 | Roger Moret | Steve Kline | Roger Moret | Steve Kline | | 459 | 419 | 40 |
| 1973-08-03 | @ BAL | 106 | W 8-5 | 57-50 | 4 | 0 | Luis Tiant | Dave McNally | Luis Tiant | Dave McNally | | 467 | 424 | 43 |
| 1973-08-03 | @ BAL | 107 | L 2-8 | 57-50 | 4 | 16,712 | Dick Pole | Jesse Jefferson | Jesse Jefferson | Dick Pole | | 469 | 432 | 37 |
| 1973-08-04 | @ BAL | 108 | L 1-4 | 57-51 | 4 | 20,029 | Bill Lee | Jim Palmer | Jim Palmer | Bill Lee | | 470 | 436 | 34 |
| 1973-08-05 | @ BAL | 109 | W 7-4 | 58-51 | 4 | 15,175 | John Curtis | Mike Cuellar | John Curtis | Mike Cuellar | | 477 | 440 | 37 |
| 1973-08-06 | @ BAL | 110 | W 5-3 | 59-51 | 3 | 12,197 | Roger Moret | Doyle Alexander | Roger Moret | Doyle Alexander | Bobby Bolin | 482 | 443 | 39 |
| 1973-08-07 | @ KCA | 111 | L 6-7 | 59-52 | 4 | 22,181 | Dick Pole | Dick Drago | Doug Bird | Craig Skok | | 488 | 450 | 38 |
| 1973-08-08 | @ KCA | 112 | W 9-4 | 60-52 | 4 | 18,985 | Luis Tiant | Paul Splittorff | Luis Tiant | Paul Splittorff | | 497 | 454 | 43 |
| 1973-08-09 | @ KCA | 113 | L 2-3 | 60-53 | 4 | 17,167 | Bill Lee | Steve Busby | Steve Busby | Bill Lee | Doug Bird | 499 | 457 | 42 |
| 1973-08-10 | vs CAL | 114 | L 3-5 | 60-54 | 4 | 24,856 | John Curtis | Dick Lange | Dave Sells | John Curtis | | 502 | 462 | 40 |
| 1973-08-11 | vs CAL | 115 | W 2-1 | 61-54 | 4 | 19,046 | Roger Moret | Nolan Ryan | Roger Moret | Nolan Ryan | Bob Veale | 504 | 463 | 41 |
| 1973-08-12 | vs CAL | 116 | W 14-8 | 62-54 | 3 | 20,522 | Dick Pole | Bill Singer | Dick Pole | Bill Singer | Bobby Bolin | 518 | 471 | 47 |
| 1973-08-13 | vs OAK | 117 | L 1-3 | 62-55 | 4 | 29,960 | Luis Tiant | Blue Moon Odom | Blue Moon Odom | Luis Tiant | Rollie Fingers | 519 | 474 | 45 |
| 1973-08-14 | vs OAK | 118 | L 0-1 | 62-56 | 4 | 29,084 | Bill Lee | Darold Knowles | Darold Knowles | Bill Lee | | 519 | 475 | 44 |
| 1973-08-16 | vs OAK | 119 | L 3-6 | 62-57 | 4 | 20,424 | John Curtis | Vida Blue | Vida Blue | John Curtis | | 522 | 481 | 41 |
| 1973-08-17 | vs KCA | 120 | W 6-4 | 63-57 | 4 | 27,224 | Roger Moret | Dick Drago | Roger Moret | Dick Drago | Marty Pattin | 528 | 485 | 43 |
| 1973-08-18 | vs KCA | 121 | W 8-5 | 64-57 | 4 | 20,065 | Dick Pole | Paul Splittorff | Dick Pole | Paul Splittorff | Bobby Bolin | 536 | 490 | 46 |
| 1973-08-19 | vs KCA | 122 | W 4-3 | 65-57 | 4 | 27,356 | Bill Lee | Al Fitzmorris | Bill Lee | Al Fitzmorris | Bobby Bolin | 540 | 493 | 47 |
| 1973-08-20 | @ TEX | 123 | W 5-4 | 66-57 | 3 | 4,608 | John Curtis | Jim Bibby | Marty Pattin | Jackie Brown | | 545 | 497 | 48 |
| 1973-08-21 | @ TEX | 124 | W 15-9 | 67-57 | 3 | 4,233 | Roger Moret | Steve Dunning | Roger Moret | Steve Dunning | Craig Skok | 560 | 506 | 54 |
| 1973-08-22 | @ TEX | 125 | W 9-8 | 68-57 | 2 | 7,787 | Dick Pole | David Clyde | Dick Pole | David Clyde | Bobby Bolin | 569 | 514 | 55 |
| 1973-08-24 | @ CAL | 126 | W 3-2 | 69-57 | 2 | 11,334 | Bill Lee | Dick Lange | Bill Lee | Dick Lange | | 572 | 516 | 56 |
| 1973-08-25 | @ CAL | 127 | W 4-0 | 70-57 | 2 | 13,679 | John Curtis | Nolan Ryan | John Curtis | Nolan Ryan | | 576 | 516 | 60 |
| 1973-08-26 | @ CAL | 128 | L 0-1 | 70-58 | 2 | 8,132 | Luis Tiant | Bill Singer | Bill Singer | Luis Tiant | | 576 | 517 | 59 |
| 1973-08-27 | @ OAK | 129 | W 5-2 | 71-58 | 2 | 32,444 | Roger Moret | Blue Moon Odom | Roger Moret | Blue Moon Odom | | 581 | 519 | 62 |
| 1973-08-28 | @ OAK | 130 | L 1-6 | 71-59 | 2 | 7,284 | Dick Pole | Catfish Hunter | Catfish Hunter | Dick Pole | Rollie Fingers | 582 | 525 | 57 |
| 1973-08-29 | @ OAK | 131 | W 6-4 | 72-59 | 2 | 7,631 | Bill Lee | Vida Blue | Bill Lee | Vida Blue | Bobby Bolin | 588 | 529 | 59 |
| 1973-08-30 | @ MIL | 132 | L 1-4 | 72-60 | 2 | 10,436 | John Curtis | Jim Slaton | Jim Slaton | John Curtis | | 589 | 533 | 56 |
| 1973-08-31 | @ MIL | 133 | L 2-3 | 72-62 | 2 | 0 | Luis Tiant | Bill Champion | Carlos Velazquez | Luis Tiant | Eduardo Rodriguez | 591 | 536 | 55 |
| 1973-08-31 | @ MIL | 134 | L 4-5 | 72-62 | 2 | 22,198 | Roger Moret | Bill Parsons | Eduardo Rodriguez | Bobby Bolin | | 595 | 541 | 54 |
| 1973-09-01 | @ MIL | 135 | W 5-0 | 73-62 | 2 | 21,410 | Marty Pattin | Skip Lockwood | Marty Pattin | Skip Lockwood | | 600 | 541 | 59 |
| 1973-09-02 | @ MIL | 136 | W 10-4 | 74-62 | 2 | 11,749 | Bill Lee | Jim Colborn | Bill Lee | Jim Colborn | | 610 | 545 | 65 |
| 1973-09-03 | vs BAL | 137 | L 8-13 | 75-63 | 2 | 27,730 | John Curtis | Doyle Alexander | Doyle Alexander | John Curtis | Eddie Watt | 618 | 558 | 60 |
| 1973-09-03 | vs BAL | 138 | W 9-8 | 75-63 | 2 | 22,267 | Dick Pole | Jesse Jefferson | Bob Veale | Eddie Watt | | 627 | 566 | 61 |
| 1973-09-04 | vs BAL | 139 | W 2-1 | 76-63 | 2 | 18,808 | Luis Tiant | Jim Palmer | Luis Tiant | Jim Palmer | | 629 | 567 | 62 |
| 1973-09-05 | vs BAL | 140 | W 7-5 | 77-63 | 2 | 21,758 | Roger Moret | Mike Cuellar | Roger Moret | Mike Cuellar | Bobby Bolin | 636 | 572 | 64 |
| 1973-09-07 | vs DET | 141 | W 11-3 | 78-63 | 2 | 29,147 | Marty Pattin | Jim Perry | Marty Pattin | Jim Perry | | 647 | 575 | 72 |
| 1973-09-08 | vs DET | 142 | L 1-6 | 78-64 | 2 | 24,694 | Bill Lee | Joe Coleman | Joe Coleman | Bill Lee | John Hiller | 648 | 581 | 67 |
| 1973-09-09 | vs DET | 143 | L 4-5 | 78-65 | 2 | 25,224 | John Curtis | Mickey Lolich | Mickey Lolich | John Curtis | John Hiller | 652 | 586 | 66 |
| 1973-09-10 | @ BAL | 144 | W 4-3 | 79-65 | 2 | 18,577 | Luis Tiant | Jesse Jefferson | Luis Tiant | Jesse Jefferson | Bobby Bolin | 656 | 589 | 67 |
| 1973-09-11 | @ BAL | 145 | L 3-8 | 79-66 | 2 | 17,278 | Marty Pattin | Dave McNally | Dave McNally | Marty Pattin | Bob Reynolds | 659 | 597 | 62 |
| 1973-09-12 | @ NYA | 146 | W 7-1 | 80-66 | 2 | 12,556 | Roger Moret | Lindy McDaniel | Roger Moret | Lindy McDaniel | | 666 | 598 | 68 |
| 1973-09-13 | @ NYA | 147 | L 1-2 | 80-67 | 2 | 9,797 | Bill Lee | Doc Medich | Sparky Lyle | Bob Veale | | 667 | 600 | 67 |
| 1973-09-14 | vs CLE | 148 | W 6-4 | 81-67 | 2 | 11,606 | Luis Tiant | Tom Timmermann | Luis Tiant | Tom Timmermann | Bobby Bolin | 673 | 604 | 69 |
| 1973-09-15 | vs CLE | 149 | L 8-9 | 81-68 | 2 | 11,478 | Marty Pattin | Dick Tidrow | Dick Tidrow | Marty Pattin | Ken Sanders | 681 | 613 | 68 |
| 1973-09-16 | vs CLE | 150 | L 1-5 | 81-69 | 2 | 12,743 | Roger Moret | Gaylord Perry | Gaylord Perry | Roger Moret | | 682 | 618 | 64 |
| 1973-09-18 | vs NYA | 151 | W 4-2 | 82-69 | 2 | 17,409 | Bill Lee | Doc Medich | Bill Lee | Doc Medich | | 686 | 620 | 66 |
| 1973-09-19 | vs NYA | 152 | W 3-1 | 83-69 | 2 | 17,453 | Luis Tiant | Mel Stottlemyre | Luis Tiant | Mel Stottlemyre | | 689 | 621 | 68 |
| 1973-09-21 | @ DET | 153 | L 1-5 | 83-70 | 2 | 14,827 | Roger Moret | Jim Perry | Jim Perry | Roger Moret | John Hiller | 690 | 626 | 64 |
| 1973-09-22 | @ DET | 154 | L 3-4 | 83-71 | 2 | 16,009 | Bill Lee | Mickey Lolich | Mickey Lolich | Bill Lee | Lerrin LaGrow | 693 | 630 | 63 |
| 1973-09-23 | @ DET | 155 | L 0-3 | 83-72 | 2 | 17,324 | Luis Tiant | Joe Coleman | Joe Coleman | Luis Tiant | | 693 | 633 | 60 |
| 1973-09-24 | @ DET | 156 | W 14-0 | 84-72 | 2 | 12,108 | Marty Pattin | Fred Holdsworth | Marty Pattin | Fred Holdsworth | | 707 | 633 | 74 |
| 1973-09-25 | @ CLE | 157 | W 3-2 | 85-72 | 2 | 2,283 | Roger Moret | Tom Timmermann | Roger Moret | Tom Timmermann | Bobby Bolin | 710 | 635 | 75 |
| 1973-09-26 | @ CLE | 158 | L 0-1 | 85-73 | 2 | 1,453 | Bill Lee | Gaylord Perry | Gaylord Perry | Bill Lee | | 710 | 636 | 74 |
| 1973-09-28 | vs MIL | 159 | W 11-2 | 87-73 | 2 | 0 | Luis Tiant | Eduardo Rodriguez | Luis Tiant | Eduardo Rodriguez | | 721 | 638 | 83 |
| 1973-09-28 | vs MIL | 160 | W 5-3 | 87-73 | 2 | 13,195 | Marty Pattin | Kevin Kobel | Marty Pattin | Kevin Kobel | | 726 | 641 | 85 |
| 1973-09-29 | vs MIL | 161 | W 9-4 | 88-73 | 2 | 6,882 | Roger Moret | Skip Lockwood | Roger Moret | Skip Lockwood | | 735 | 645 | 90 |
| 1973-09-30 | vs MIL | 162 | W 3-2 | 89-73 | 2 | 11,675 | John Curtis | Jim Colborn | John Curtis | Jim Colborn | Bobby Bolin | 738 | 647 | 91 |