| 1973-04-07 | vs CHA | 1 | L 1-3 | 0-1 | 6 | 22,114 | Dick Bosman | Wilbur Wood | Wilbur Wood | Dick Bosman | | 1 | 3 | -2 |
| 1973-04-10 | @ KCA | 2 | L 1-12 | 0-2 | 6 | 39,464 | Pete Broberg | Paul Splittorff | Paul Splittorff | Pete Broberg | | 2 | 15 | -13 |
| 1973-04-11 | @ KCA | 3 | L 6-9 | 0-3 | 6 | 8,581 | Don Stanhouse | Steve Busby | Gene Garber | Don Stanhouse | | 8 | 24 | -16 |
| 1973-04-12 | @ KCA | 4 | W 4-0 | 1-3 | 5 | 9,345 | Dick Bosman | Wayne Simpson | Dick Bosman | Wayne Simpson | | 12 | 24 | -12 |
| 1973-04-13 | vs CAL | 5 | W 4-2 | 2-3 | 5 | 11,047 | Mike Paul | Clyde Wright | Mike Paul | Clyde Wright | Steve Foucault | 16 | 26 | -10 |
| 1973-04-17 | @ CHA | 6 | L 5-10 | 2-4 | 5 | 2,718 | Dick Bosman | Eddie Fisher | Eddie Fisher | Dick Bosman | | 21 | 36 | -15 |
| 1973-04-18 | @ CHA | 7 | L 5-6 | 2-5 | 6 | 5,545 | Mike Paul | Wilbur Wood | Wilbur Wood | Don Stanhouse | Terry Forster | 26 | 42 | -16 |
| 1973-04-20 | @ MIN | 8 | L 1-5 | 2-6 | 6 | 4,600 | Rich Hand | Bill Hands | Bill Hands | Rich Hand | | 27 | 47 | -20 |
| 1973-04-21 | @ MIN | 9 | L 4-5 | 2-7 | 6 | 9,397 | Pete Broberg | Jim Kaat | Ken Sanders | Steve Foucault | | 31 | 52 | -21 |
| 1973-04-22 | @ MIN | 10 | L 4-6 | 2-8 | 6 | 4,415 | Dick Bosman | Bert Blyleven | Bert Blyleven | Dick Bosman | Ray Corbin | 35 | 58 | -23 |
| 1973-04-24 | vs DET | 11 | W 2-1 | 3-8 | 6 | 7,119 | Mike Paul | Mickey Lolich | Mike Paul | Mickey Lolich | Steve Foucault | 37 | 59 | -22 |
| 1973-04-25 | vs DET | 12 | W 4-1 | 4-8 | 6 | 7,386 | Rich Hand | Joe Coleman | Rich Hand | Joe Coleman | Steve Foucault | 41 | 60 | -19 |
| 1973-04-26 | vs DET | 13 | L 2-3 | 4-9 | 6 | 5,399 | Pete Broberg | Woodie Fryman | Woodie Fryman | Pete Broberg | John Hiller | 43 | 63 | -20 |
| 1973-04-27 | vs MIL | 14 | W 4-2 | 5-9 | 6 | 10,116 | Dick Bosman | Skip Lockwood | Dick Bosman | Skip Lockwood | Steve Foucault | 47 | 65 | -18 |
| 1973-04-28 | vs MIL | 15 | L 3-4 | 5-10 | 6 | 11,504 | Don Stanhouse | Jerry Bell | Jerry Bell | Don Stanhouse | | 50 | 69 | -19 |
| 1973-04-29 | vs MIL | 16 | W 2-1 | 6-10 | 6 | 5,157 | Mike Paul | Jim Slaton | Mike Paul | Ray Newman | | 52 | 70 | -18 |
| 1973-05-01 | @ BOS | 17 | W 7-6 | 7-10 | 6 | 8,616 | Rich Hand | Bill Lee | Steve Foucault | Lynn McGlothen | | 59 | 76 | -17 |
| 1973-05-02 | @ BOS | 18 | L 2-6 | 7-11 | 6 | 8,247 | Pete Broberg | Luis Tiant | Luis Tiant | Pete Broberg | | 61 | 82 | -21 |
| 1973-05-04 | @ DET | 19 | L 1-5 | 7-12 | 6 | 9,639 | Dick Bosman | Jim Perry | Jim Perry | Dick Bosman | John Hiller | 62 | 87 | -25 |
| 1973-05-05 | @ DET | 20 | L 0-2 | 7-13 | 6 | 11,033 | Mike Paul | Joe Coleman | Joe Coleman | Mike Paul | John Hiller | 62 | 89 | -27 |
| 1973-05-06 | @ DET | 21 | W 7-2 | 8-13 | 6 | 14,600 | Rich Hand | Mickey Lolich | Rich Hand | Mickey Lolich | | 69 | 91 | -22 |
| 1973-05-08 | @ MIL | 22 | W 5-3 | 9-13 | 6 | 4,005 | Pete Broberg | Jim Slaton | Charlie Hudson | Bill Champion | Steve Foucault | 74 | 94 | -20 |
| 1973-05-09 | @ MIL | 23 | L 1-5 | 9-14 | 6 | 6,049 | Dick Bosman | Jim Colborn | Jim Colborn | Dick Bosman | | 75 | 99 | -24 |
| 1973-05-10 | vs OAK | 24 | L 2-17 | 9-15 | 6 | 6,024 | Mike Paul | Ken Holtzman | Ken Holtzman | Mike Paul | Horacio Pina | 77 | 116 | -39 |
| 1973-05-11 | vs OAK | 25 | L 3-4 | 9-16 | 6 | 18,529 | Rich Hand | Vida Blue | Vida Blue | Rich Hand | Rollie Fingers | 80 | 120 | -40 |
| 1973-05-12 | vs OAK | 26 | L 2-4 | 9-17 | 6 | 17,075 | Pete Broberg | Blue Moon Odom | Blue Moon Odom | Pete Broberg | Paul Lindblad | 82 | 124 | -42 |
| 1973-05-13 | vs OAK | 27 | W 7-2 | 10-17 | 6 | 7,194 | Sonny Siebert | Catfish Hunter | Sonny Siebert | Catfish Hunter | Bill Gogolewski | 89 | 126 | -37 |
| 1973-05-14 | vs MIN | 28 | W 7-6 | 11-18 | 6 | 0 | Mike Paul | Jim Kaat | Charlie Hudson | Ken Sanders | | 96 | 132 | -36 |
| 1973-05-14 | vs MIN | 29 | L 4-6 | 11-18 | 6 | 5,072 | Rich Hand | Ray Corbin | Dave Goltz | Steve Foucault | | 100 | 138 | -38 |
| 1973-05-15 | vs MIN | 30 | L 5-9 | 11-19 | 6 | 3,697 | Don Stanhouse | Bert Blyleven | Bert Blyleven | Bill Gogolewski | | 105 | 147 | -42 |
| 1973-05-16 | vs KCA | 31 | W 2-1 | 12-19 | 6 | 16,663 | Pete Broberg | Paul Splittorff | Steve Foucault | Paul Splittorff | | 107 | 148 | -41 |
| 1973-05-17 | vs KCA | 32 | L 1-6 | 12-20 | 6 | 5,522 | Sonny Siebert | Wayne Simpson | Wayne Simpson | Sonny Siebert | Gene Garber | 108 | 154 | -46 |
| 1973-05-18 | @ CAL | 33 | L 1-7 | 12-21 | 6 | 13,926 | Mike Paul | Bill Singer | Bill Singer | Mike Paul | | 109 | 161 | -52 |
| 1973-05-19 | @ CAL | 34 | L 1-9 | 12-22 | 6 | 15,019 | Rich Hand | Nolan Ryan | Nolan Ryan | Rich Hand | | 110 | 170 | -60 |
| 1973-05-20 | @ CAL | 35 | L 2-4 | 12-23 | 6 | 15,689 | Don Stanhouse | Clyde Wright | Clyde Wright | Don Stanhouse | Dave Sells | 112 | 174 | -62 |
| 1973-05-22 | @ OAK | 36 | L 1-4 | 12-24 | 6 | 3,196 | Sonny Siebert | Ken Holtzman | Ken Holtzman | Sonny Siebert | | 113 | 178 | -65 |
| 1973-05-23 | @ OAK | 37 | L 6-8 | 12-25 | 6 | 3,471 | Pete Broberg | Vida Blue | Horacio Pina | Bill Gogolewski | Rollie Fingers | 119 | 186 | -67 |
| 1973-05-25 | @ NYA | 38 | L 7-9 | 12-26 | 6 | 6,809 | Mike Paul | Mike Kekich | Lindy McDaniel | Steve Foucault | Sparky Lyle | 126 | 195 | -69 |
| 1973-05-26 | @ NYA | 39 | L 5-10 | 12-27 | 6 | 8,167 | Don Stanhouse | Mel Stottlemyre | Mel Stottlemyre | Don Stanhouse | Fred Beene | 131 | 205 | -74 |
| 1973-05-27 | @ NYA | 40 | W 5-2 | 13-27 | 6 | 12,550 | Sonny Siebert | Steve Kline | Sonny Siebert | Steve Kline | Bill Gogolewski | 136 | 207 | -71 |
| 1973-05-29 | vs CLE | 41 | L 7-9 | 13-28 | 6 | 4,676 | Lloyd Allen | Dick Bosman | Tom Hilgendorf | Lloyd Allen | Jerry Johnson | 143 | 216 | -73 |
| 1973-05-30 | vs CLE | 42 | W 3-2 | 14-28 | 6 | 5,128 | Pete Broberg | Gaylord Perry | Pete Broberg | Gaylord Perry | | 146 | 218 | -72 |
| 1973-05-31 | vs CLE | 43 | W 9-5 | 15-28 | 6 | 5,571 | Sonny Siebert | Brent Strom | Sonny Siebert | Brent Strom | Bill Gogolewski | 155 | 223 | -68 |
| 1973-06-01 | vs BAL | 44 | W 4-3 | 16-28 | 6 | 6,300 | Jim Merritt | Doyle Alexander | Mike Paul | Bob Reynolds | | 159 | 226 | -67 |
| 1973-06-02 | vs BAL | 45 | L 3-8 | 16-29 | 6 | 13,693 | Lloyd Allen | Jim Palmer | Jim Palmer | Lloyd Allen | | 162 | 234 | -72 |
| 1973-06-03 | vs BAL | 46 | L 1-7 | 16-30 | 6 | 6,905 | Pete Broberg | Dave McNally | Dave McNally | Pete Broberg | | 163 | 241 | -78 |
| 1973-06-05 | vs NYA | 47 | L 6-8 | 16-31 | 6 | 10,210 | Sonny Siebert | Mel Stottlemyre | Lindy McDaniel | Sonny Siebert | Sparky Lyle | 169 | 249 | -80 |
| 1973-06-06 | vs NYA | 48 | L 2-5 | 16-32 | 6 | 9,072 | Jim Merritt | Steve Kline | Steve Kline | Jim Merritt | Sparky Lyle | 171 | 254 | -83 |
| 1973-06-07 | vs NYA | 49 | W 7-5 | 17-32 | 6 | 10,278 | Lloyd Allen | Fritz Peterson | Don Stanhouse | Lindy McDaniel | Charlie Hudson | 178 | 259 | -81 |
| 1973-06-08 | vs BOS | 50 | W 5-2 | 18-32 | 6 | 8,231 | Pete Broberg | John Curtis | Pete Broberg | John Curtis | Bill Gogolewski | 183 | 261 | -78 |
| 1973-06-09 | vs BOS | 51 | L 1-12 | 18-33 | 6 | 12,624 | Steve Dunning | Marty Pattin | Marty Pattin | Steve Dunning | Bob Veale | 184 | 273 | -89 |
| 1973-06-10 | vs BOS | 52 | L 1-10 | 18-34 | 6 | 9,729 | Sonny Siebert | Bill Lee | Bill Lee | Sonny Siebert | | 185 | 283 | -98 |
| 1973-06-12 | @ CLE | 53 | L 4-5 | 18-35 | 6 | 2,105 | Jim Merritt | Milt Wilcox | Milt Wilcox | Jim Merritt | Tom Hilgendorf | 189 | 288 | -99 |
| 1973-06-13 | @ CLE | 54 | W 4-2 | 19-35 | 6 | 3,673 | Pete Broberg | Gaylord Perry | Pete Broberg | Gaylord Perry | Don Stanhouse | 193 | 290 | -97 |
| 1973-06-15 | @ BAL | 55 | L 0-1 | 19-36 | 6 | 7,792 | Sonny Siebert | Mike Cuellar | Mike Cuellar | Sonny Siebert | | 193 | 291 | -98 |
| 1973-06-16 | @ BAL | 56 | L 1-9 | 19-37 | 6 | 8,587 | Steve Dunning | Jim Palmer | Jim Palmer | Steve Dunning | | 194 | 300 | -106 |
| 1973-06-17 | @ BAL | 57 | L 4-5 | 19-38 | 6 | 14,497 | Jim Merritt | Dave McNally | Bob Reynolds | Don Stanhouse | | 198 | 305 | -107 |
| 1973-06-18 | @ MIN | 58 | W 7-4 | 20-38 | 6 | 8,073 | Pete Broberg | Bill Hands | Pete Broberg | Bill Hands | Mike Paul | 205 | 309 | -104 |
| 1973-06-19 | @ MIN | 59 | L 3-7 | 20-39 | 6 | 7,022 | Jim Bibby | Jim Kaat | Jim Kaat | Jim Bibby | Ray Corbin | 208 | 316 | -108 |
| 1973-06-20 | @ MIN | 60 | W 3-0 | 21-39 | 6 | 6,318 | Sonny Siebert | Dick Woodson | Sonny Siebert | Dick Woodson | | 211 | 316 | -105 |
| 1973-06-22 | @ KCA | 61 | W 3-0 | 22-39 | 6 | 14,320 | Jim Merritt | Dick Drago | Jim Merritt | Dick Drago | Bill Gogolewski | 214 | 316 | -102 |
| 1973-06-23 | @ KCA | 62 | L 7-8 | 22-40 | 6 | 11,672 | Pete Broberg | Paul Splittorff | Ken Wright | Mike Paul | | 221 | 324 | -103 |
| 1973-06-24 | @ KCA | 63 | L 4-7 | 22-42 | 6 | 0 | Jim Bibby | Steve Busby | Steve Busby | Jim Bibby | | 225 | 331 | -106 |
| 1973-06-24 | @ KCA | 64 | L 6-10 | 22-42 | 6 | 20,050 | Lloyd Allen | Mark Littell | Mark Littell | Lloyd Allen | Bruce Dal Canton | 231 | 341 | -110 |
| 1973-06-25 | vs OAK | 65 | W 4-2 | 23-42 | 6 | 5,356 | Sonny Siebert | Ken Holtzman | Sonny Siebert | Ken Holtzman | Steve Foucault | 235 | 343 | -108 |
| 1973-06-26 | vs OAK | 66 | L 2-6 | 23-43 | 6 | 6,238 | Jim Merritt | Dave Hamilton | Dave Hamilton | Jim Merritt | Rollie Fingers | 237 | 349 | -112 |
| 1973-06-27 | vs MIN | 67 | W 4-3 | 24-43 | 6 | 35,698 | David Clyde | Jim Kaat | David Clyde | Jim Kaat | Bill Gogolewski | 241 | 352 | -111 |
| 1973-06-28 | vs MIN | 68 | L 0-4 | 24-44 | 6 | 3,992 | Pete Broberg | Dick Woodson | Dick Woodson | Pete Broberg | | 241 | 356 | -115 |
| 1973-06-29 | vs KCA | 69 | W 3-0 | 25-44 | 6 | 9,619 | Jim Bibby | Mark Littell | Jim Bibby | Mark Littell | | 244 | 356 | -112 |
| 1973-06-30 | vs KCA | 70 | L 3-8 | 25-46 | 6 | 0 | Steve Dunning | Dick Drago | Dick Drago | Bill Gogolewski | | 247 | 364 | -117 |
| 1973-06-30 | vs KCA | 71 | L 2-4 | 25-46 | 6 | 11,461 | Sonny Siebert | Ken Wright | Ken Wright | Sonny Siebert | Doug Bird | 249 | 368 | -119 |
| 1973-07-01 | vs KCA | 72 | W 8-3 | 26-46 | 6 | 4,642 | Jim Merritt | Paul Splittorff | Jim Merritt | Paul Splittorff | | 257 | 371 | -114 |
| 1973-07-02 | vs CHA | 73 | L 4-5 | 26-47 | 6 | 33,010 | David Clyde | Steve Stone | Cy Acosta | Don Stanhouse | | 261 | 376 | -115 |
| 1973-07-03 | vs CHA | 74 | L 1-15 | 27-48 | 6 | 0 | Pete Broberg | Wilbur Wood | Wilbur Wood | Pete Broberg | | 262 | 391 | -129 |
| 1973-07-03 | vs CHA | 75 | W 2-1 | 27-48 | 6 | 7,641 | Jim Bibby | Stan Bahnsen | Jim Bibby | Stan Bahnsen | | 264 | 392 | -128 |
| 1973-07-04 | vs CHA | 76 | L 0-2 | 27-50 | 6 | 0 | Steve Dunning | Jim Geddes | Cy Acosta | Steve Dunning | | 264 | 394 | -130 |
| 1973-07-04 | vs CHA | 77 | L 2-6 | 27-50 | 6 | 13,362 | Jim Kremmel | Bart Johnson | Bart Johnson | Jim Kremmel | Terry Forster | 266 | 400 | -134 |
| 1973-07-05 | vs CHA | 78 | W 7-2 | 28-50 | 6 | 4,165 | Sonny Siebert | Steve Stone | Sonny Siebert | Steve Stone | Jim Bibby | 273 | 402 | -129 |
| 1973-07-06 | @ MIL | 79 | W 5-2 | 29-50 | 6 | 12,609 | Jim Merritt | Jim Colborn | Jim Merritt | Jim Colborn | | 278 | 404 | -126 |
| 1973-07-07 | @ MIL | 80 | L 2-17 | 29-51 | 6 | 15,122 | David Clyde | Eduardo Rodriguez | Eduardo Rodriguez | David Clyde | | 280 | 421 | -141 |
| 1973-07-08 | @ MIL | 81 | L 4-6 | 29-53 | 6 | 0 | Jim Bibby | Jim Slaton | Jim Slaton | Jim Bibby | Frank Linzy | 284 | 427 | -143 |
| 1973-07-08 | @ MIL | 82 | L 3-7 | 29-53 | 6 | 31,907 | Jim Kremmel | Chris Short | Skip Lockwood | Jim Kremmel | | 287 | 434 | -147 |
| 1973-07-09 | @ DET | 83 | W 9-7 | 30-53 | 6 | 21,933 | Steve Dunning | Mickey Lolich | Bill Gogolewski | Bob Miller | | 296 | 441 | -145 |
| 1973-07-10 | @ DET | 84 | L 4-5 | 30-54 | 6 | 15,534 | Jim Merritt | Joe Coleman | Joe Coleman | Jim Merritt | John Hiller | 300 | 446 | -146 |
| 1973-07-11 | @ DET | 85 | L 2-14 | 30-55 | 6 | 13,326 | Lloyd Allen | Jim Perry | Jim Perry | Lloyd Allen | Ed Farmer | 302 | 460 | -158 |
| 1973-07-12 | @ BOS | 86 | L 2-5 | 30-56 | 6 | 31,896 | David Clyde | Marty Pattin | Marty Pattin | David Clyde | | 304 | 465 | -161 |
| 1973-07-13 | @ BOS | 87 | W 4-1 | 31-56 | 6 | 19,375 | Jim Bibby | Ray Culp | Jim Bibby | Ray Culp | | 308 | 466 | -158 |
| 1973-07-14 | @ BOS | 88 | L 5-6 | 31-57 | 6 | 13,253 | Steve Dunning | Bill Lee | Bobby Bolin | Jackie Brown | Bob Veale | 313 | 472 | -159 |
| 1973-07-15 | @ BOS | 89 | L 1-3 | 31-58 | 6 | 11,793 | Jim Merritt | Luis Tiant | Luis Tiant | Jim Merritt | | 314 | 475 | -161 |
| 1973-07-17 | vs MIL | 90 | L 3-6 | 31-59 | 6 | 23,102 | David Clyde | Jim Slaton | Jim Slaton | David Clyde | Eduardo Rodriguez | 317 | 481 | -164 |
| 1973-07-18 | vs MIL | 91 | L 0-3 | 31-60 | 6 | 5,685 | Jim Bibby | Jim Colborn | Jim Colborn | Jim Bibby | | 317 | 484 | -167 |
| 1973-07-19 | vs MIL | 92 | L 1-4 | 31-61 | 6 | 5,213 | Steve Dunning | Skip Lockwood | Skip Lockwood | Steve Dunning | Eduardo Rodriguez | 318 | 488 | -170 |
| 1973-07-20 | vs DET | 93 | W 8-6 | 32-61 | 6 | 8,770 | Jim Merritt | Jim Perry | Bill Gogolewski | Jim Perry | Mike Paul | 326 | 494 | -168 |
| 1973-07-21 | vs DET | 94 | W 4-3 | 33-61 | 6 | 21,643 | David Clyde | Mickey Lolich | Jackie Brown | Mickey Lolich | | 330 | 497 | -167 |
| 1973-07-22 | vs DET | 95 | W 4-3 | 34-61 | 6 | 7,187 | Jim Bibby | Joe Coleman | Jackie Brown | John Hiller | | 334 | 500 | -166 |
| 1973-07-26 | vs CAL | 96 | W 7-1 | 36-61 | 6 | 0 | Jim Bibby | Nolan Ryan | Jim Bibby | Nolan Ryan | | 341 | 501 | -160 |
| 1973-07-26 | vs CAL | 97 | W 8-0 | 36-61 | 6 | 25,620 | David Clyde | Bill Singer | David Clyde | Bill Singer | Jackie Brown | 349 | 501 | -152 |
| 1973-07-27 | vs CAL | 98 | W 5-2 | 37-61 | 6 | 3,317 | Jim Merritt | Clyde Wright | Jim Merritt | Clyde Wright | | 354 | 503 | -149 |
| 1973-07-28 | @ OAK | 99 | L 4-6 | 37-62 | 6 | 9,073 | Steve Dunning | Blue Moon Odom | Darold Knowles | Bill Gogolewski | | 358 | 509 | -151 |
| 1973-07-29 | @ OAK | 100 | W 3-0 | 38-63 | 6 | 0 | Jackie Brown | Paul Lindblad | Jackie Brown | Paul Lindblad | | 361 | 509 | -148 |
| 1973-07-29 | @ OAK | 101 | L 4-7 | 38-63 | 6 | 11,144 | Don Durham | Glenn Abbott | Dave Hamilton | Don Durham | Horacio Pina | 365 | 516 | -151 |
| 1973-07-30 | @ OAK | 102 | W 6-0 | 39-63 | 6 | 21,606 | Jim Bibby | Vida Blue | Jim Bibby | Vida Blue | | 371 | 516 | -145 |
| 1973-07-31 | @ CAL | 103 | W 4-2 | 40-63 | 6 | 11,147 | David Clyde | Clyde Wright | David Clyde | Clyde Wright | Don Durham | 375 | 518 | -143 |
| 1973-08-01 | @ CAL | 104 | L 1-5 | 40-64 | 6 | 8,087 | Jim Merritt | Rudy May | Rudy May | Jim Merritt | | 376 | 523 | -147 |
| 1973-08-02 | @ CAL | 105 | L 2-3 | 40-65 | 6 | 7,500 | Sonny Siebert | Nolan Ryan | Nolan Ryan | Sonny Siebert | | 378 | 526 | -148 |
| 1973-08-03 | @ CHA | 106 | L 3-5 | 40-66 | 6 | 24,860 | Jim Bibby | Steve Stone | Terry Forster | Jim Bibby | | 381 | 531 | -150 |
| 1973-08-04 | @ CHA | 107 | W 9-3 | 41-66 | 6 | 17,741 | Jackie Brown | Wilbur Wood | Jackie Brown | Wilbur Wood | | 390 | 534 | -144 |
| 1973-08-05 | @ CHA | 108 | L 3-7 | 41-68 | 6 | 0 | Don Durham | Stan Bahnsen | Stan Bahnsen | Don Durham | Terry Forster | 393 | 541 | -148 |
| 1973-08-05 | @ CHA | 109 | L 4-5 | 41-68 | 6 | 27,931 | David Clyde | Bart Johnson | Cy Acosta | Charlie Hudson | | 397 | 546 | -149 |
| 1973-08-07 | @ NYA | 110 | W 2-1 | 42-69 | 6 | 0 | Jim Bibby | Sam McDowell | Jim Bibby | Sam McDowell | | 399 | 547 | -148 |
| 1973-08-07 | @ NYA | 111 | L 1-3 | 42-69 | 6 | 16,842 | Sonny Siebert | Doc Medich | Doc Medich | Sonny Siebert | Lindy McDaniel | 400 | 550 | -150 |
| 1973-08-08 | @ NYA | 112 | L 2-3 | 42-70 | 6 | 17,433 | Jim Merritt | Fritz Peterson | Fred Beene | Jim Merritt | | 402 | 553 | -151 |
| 1973-08-10 | vs CLE | 113 | L 1-8 | 42-71 | 6 | 28,326 | David Clyde | Gaylord Perry | Gaylord Perry | David Clyde | | 403 | 561 | -158 |
| 1973-08-11 | vs CLE | 114 | L 2-5 | 42-72 | 6 | 12,982 | Jim Bibby | Tom Timmermann | Tom Timmermann | Jim Bibby | Ken Sanders | 405 | 566 | -161 |
| 1973-08-12 | vs CLE | 115 | L 6-7 | 42-73 | 6 | 4,905 | Jackie Brown | Dick Tidrow | Ken Sanders | Bill Gogolewski | | 411 | 573 | -162 |
| 1973-08-13 | vs BAL | 116 | L 4-7 | 42-74 | 6 | 4,709 | Jim Merritt | Mike Cuellar | Mike Cuellar | Jim Merritt | | 415 | 580 | -165 |
| 1973-08-14 | vs BAL | 117 | L 10-12 | 42-75 | 6 | 5,261 | Sonny Siebert | Doyle Alexander | Grant Jackson | Sonny Siebert | | 425 | 592 | -167 |
| 1973-08-15 | vs BAL | 118 | L 1-5 | 42-76 | 6 | 8,033 | Jim Bibby | Dave McNally | Dave McNally | Jim Bibby | | 426 | 597 | -171 |
| 1973-08-17 | vs NYA | 119 | W 8-1 | 43-76 | 6 | 19,600 | David Clyde | Sam McDowell | David Clyde | Sam McDowell | Jackie Brown | 434 | 598 | -164 |
| 1973-08-18 | vs NYA | 120 | L 3-5 | 43-77 | 6 | 11,749 | Jim Merritt | Doc Medich | Doc Medich | Jim Merritt | Lindy McDaniel | 437 | 603 | -166 |
| 1973-08-19 | vs NYA | 121 | L 2-6 | 43-78 | 6 | 11,173 | Sonny Siebert | Pat Dobson | Pat Dobson | Sonny Siebert | | 439 | 609 | -170 |
| 1973-08-20 | vs BOS | 122 | L 4-5 | 43-79 | 6 | 4,608 | Jim Bibby | John Curtis | Marty Pattin | Jackie Brown | | 443 | 614 | -171 |
| 1973-08-21 | vs BOS | 123 | L 9-15 | 43-80 | 6 | 4,233 | Steve Dunning | Roger Moret | Roger Moret | Steve Dunning | Craig Skok | 452 | 629 | -177 |
| 1973-08-22 | vs BOS | 124 | L 8-9 | 43-81 | 6 | 7,787 | David Clyde | Dick Pole | Dick Pole | David Clyde | Bobby Bolin | 460 | 638 | -178 |
| 1973-08-24 | @ CLE | 125 | L 5-11 | 43-82 | 6 | 5,736 | Don Durham | Tom Timmermann | Tom Timmermann | Don Durham | | 465 | 649 | -184 |
| 1973-08-25 | @ CLE | 126 | L 5-6 | 43-83 | 6 | 4,218 | Jim Bibby | Dick Tidrow | Ken Sanders | Jackie Brown | | 470 | 655 | -185 |
| 1973-08-26 | @ CLE | 127 | W 9-0 | 45-83 | 6 | 0 | Jim Merritt | Gaylord Perry | Jim Merritt | Gaylord Perry | | 479 | 655 | -176 |
| 1973-08-26 | @ CLE | 128 | W 5-3 | 45-83 | 6 | 12,563 | Mike Paul | Milt Wilcox | Mike Paul | Milt Wilcox | Sonny Siebert | 484 | 658 | -174 |
| 1973-08-27 | @ BAL | 129 | L 1-6 | 45-84 | 6 | 12,477 | David Clyde | Mike Cuellar | Mike Cuellar | David Clyde | | 485 | 664 | -179 |
| 1973-08-28 | @ BAL | 130 | W 5-3 | 46-84 | 6 | 10,524 | Charlie Hudson | Dave McNally | Charlie Hudson | Dave McNally | Sonny Siebert | 490 | 667 | -177 |
| 1973-08-29 | @ BAL | 131 | L 1-6 | 46-85 | 6 | 9,845 | Don Durham | Doyle Alexander | Doyle Alexander | Don Durham | | 491 | 673 | -182 |
| 1973-08-30 | vs MIN | 132 | L 2-5 | 46-86 | 6 | 4,012 | Jim Bibby | Bert Blyleven | Bert Blyleven | Jim Bibby | Bill Campbell | 493 | 678 | -185 |
| 1973-08-31 | vs MIN | 133 | L 2-11 | 46-87 | 6 | 4,445 | Jim Merritt | Danny Fife | Danny Fife | Jim Merritt | Ray Corbin | 495 | 689 | -194 |
| 1973-09-01 | vs MIN | 134 | L 7-10 | 46-88 | 6 | 7,798 | David Clyde | Eddie Bane | Bill Hands | Jackie Brown | | 502 | 699 | -197 |
| 1973-09-02 | vs MIN | 135 | W 2-0 | 47-88 | 6 | 3,242 | Charlie Hudson | Joe Decker | Charlie Hudson | Joe Decker | | 504 | 699 | -195 |
| 1973-09-03 | @ CHA | 136 | L 7-8 | 47-90 | 6 | 0 | Rick Henninger | Wilbur Wood | Cy Acosta | Steve Foucault | | 511 | 707 | -196 |
| 1973-09-03 | @ CHA | 137 | L 2-5 | 47-90 | 6 | 12,387 | Jim Merritt | Terry Forster | Terry Forster | Jim Merritt | | 513 | 712 | -199 |
| 1973-09-04 | @ CHA | 138 | L 0-14 | 47-91 | 6 | 5,502 | Jim Bibby | Jim Kaat | Jim Kaat | Jim Bibby | | 513 | 726 | -213 |
| 1973-09-07 | vs OAK | 139 | W 10-8 | 48-91 | 6 | 5,014 | David Clyde | Blue Moon Odom | Bill Gogolewski | Darold Knowles | Jim Merritt | 523 | 734 | -211 |
| 1973-09-08 | vs OAK | 140 | W 4-3 | 49-91 | 6 | 6,086 | Rick Henninger | Ken Holtzman | Jackie Brown | Paul Lindblad | | 527 | 737 | -210 |
| 1973-09-09 | vs OAK | 141 | W 5-3 | 50-91 | 6 | 4,294 | Jim Bibby | Catfish Hunter | Jim Bibby | Catfish Hunter | Lloyd Allen | 532 | 740 | -208 |
| 1973-09-10 | @ MIN | 142 | L 4-5 | 50-92 | 6 | 5,063 | Charlie Hudson | Danny Fife | Ray Corbin | Bill Gogolewski | | 536 | 745 | -209 |
| 1973-09-11 | @ MIN | 143 | L 3-6 | 50-93 | 6 | 3,912 | Sonny Siebert | Joe Decker | Joe Decker | Sonny Siebert | Bill Hands | 539 | 751 | -212 |
| 1973-09-12 | @ MIN | 144 | W 5-2 | 51-93 | 6 | 4,597 | David Clyde | Eddie Bane | Rick Henninger | Eddie Bane | | 544 | 753 | -209 |
| 1973-09-14 | @ OAK | 145 | L 1-5 | 51-94 | 6 | 4,690 | Jim Bibby | Catfish Hunter | Catfish Hunter | Lloyd Allen | | 545 | 758 | -213 |
| 1973-09-15 | @ OAK | 146 | L 1-3 | 51-95 | 6 | 8,360 | Pete Broberg | Vida Blue | Vida Blue | Pete Broberg | Rollie Fingers | 546 | 761 | -215 |
| 1973-09-16 | @ OAK | 147 | L 4-9 | 51-96 | 6 | 10,907 | Steve Dunning | Glenn Abbott | Blue Moon Odom | Steve Dunning | | 550 | 770 | -220 |
| 1973-09-17 | vs CHA | 148 | W 10-3 | 52-96 | 6 | 2,608 | Sonny Siebert | Jim Kaat | Sonny Siebert | Jim Kaat | Rick Waits | 560 | 773 | -213 |
| 1973-09-18 | vs CHA | 149 | W 7-2 | 53-96 | 6 | 3,076 | Jim Bibby | Stan Bahnsen | Jim Bibby | Stan Bahnsen | | 567 | 775 | -208 |
| 1973-09-19 | vs CAL | 150 | L 2-6 | 53-98 | 6 | 0 | Pete Broberg | Nolan Ryan | Nolan Ryan | Pete Broberg | | 569 | 781 | -212 |
| 1973-09-19 | vs CAL | 151 | L 4-9 | 53-98 | 6 | 3,347 | Charlie Hudson | Clyde Wright | Clyde Wright | Charlie Hudson | | 573 | 790 | -217 |
| 1973-09-20 | vs CAL | 152 | L 4-6 | 54-99 | 6 | 0 | Bill Gogolewski | Bill Singer | Bill Singer | Jim Merritt | | 577 | 796 | -219 |
| 1973-09-20 | vs CAL | 153 | W 8-3 | 54-99 | 6 | 2,583 | Steve Dunning | Frank Tanana | Steve Dunning | Frank Tanana | Steve Foucault | 585 | 799 | -214 |
| 1973-09-21 | vs CAL | 154 | L 1-6 | 54-100 | 6 | 2,513 | David Clyde | Rich Hand | Rich Hand | David Clyde | Aurelio Monteagudo | 586 | 805 | -219 |
| 1973-09-22 | @ KCA | 155 | L 3-5 | 54-101 | 6 | 15,190 | Sonny Siebert | Al Fitzmorris | Steve Mingori | Jackie Brown | | 589 | 810 | -221 |
| 1973-09-23 | @ KCA | 156 | L 4-7 | 54-102 | 6 | 11,183 | Jim Bibby | Paul Splittorff | Paul Splittorff | Jim Bibby | Doug Bird | 593 | 817 | -224 |
| 1973-09-24 | @ CAL | 157 | L 9-10 | 54-103 | 6 | 3,753 | Pete Broberg | Clyde Wright | Steve Barber | Lloyd Allen | | 602 | 827 | -225 |
| 1973-09-25 | @ CAL | 158 | W 4-1 | 55-103 | 6 | 5,044 | Steve Dunning | Bill Singer | Steve Dunning | Bill Singer | Steve Foucault | 606 | 828 | -222 |
| 1973-09-26 | @ CAL | 159 | L 4-5 | 55-104 | 6 | 3,923 | Sonny Siebert | Rich Hand | Dave Sells | Jim Merritt | | 610 | 833 | -223 |
| 1973-09-28 | vs KCA | 160 | W 5-4 | 56-104 | 6 | 4,445 | Jim Bibby | Mark Littell | Jim Bibby | Mark Littell | | 615 | 837 | -222 |
| 1973-09-29 | vs KCA | 161 | L 1-7 | 56-105 | 6 | 8,139 | David Clyde | Steve Busby | Steve Busby | David Clyde | Doug Bird | 616 | 844 | -228 |
| 1973-09-30 | vs KCA | 162 | W 3-0 | 57-105 | 6 | 3,438 | Pete Broberg | Steve Mingori | Pete Broberg | Steve Mingori | | 619 | 844 | -225 |