| 1973-04-06 | @ CHN | 1 | L 2-3 | 0-1 | 4 | 40,273 | Mike Torrez | Fergie Jenkins | Bob Locker | Mike Torrez | | 2 | 3 | -1 |
| 1973-04-07 | @ CHN | 2 | L 2-3 | 0-2 | 4 | 22,562 | Balor Moore | Milt Pappas | Jack Aker | Mike Marshall | | 4 | 6 | -2 |
| 1973-04-08 | @ CHN | 3 | W 5-2 | 1-2 | 4 | 12,963 | Ernie McAnally | Burt Hooton | Ernie McAnally | Burt Hooton | | 9 | 8 | 1 |
| 1973-04-10 | @ PHI | 4 | L 5-7 | 1-3 | 5 | 40,809 | Mike Torrez | Steve Carlton | Steve Carlton | Mike Torrez | | 14 | 15 | -1 |
| 1973-04-12 | @ PHI | 5 | W 5-3 | 2-3 | 4 | 5,130 | Balor Moore | Jim Lonborg | Balor Moore | Jim Lonborg | Mike Marshall | 19 | 18 | 1 |
| 1973-04-14 | vs PIT | 6 | W 6-4 | 3-3 | 4 | 21,198 | Ernie McAnally | Nelson Briles | Tom Walker | Nelson Briles | | 25 | 22 | 3 |
| 1973-04-15 | vs PIT | 7 | L 3-8 | 3-4 | 4 | 12,101 | Mike Torrez | Dock Ellis | Dock Ellis | Mike Torrez | Dave Giusti | 28 | 30 | -2 |
| 1973-04-17 | vs PHI | 8 | L 6-9 | 3-5 | 5 | 7,831 | Balor Moore | Dick Ruthven | Dick Selma | Mike Marshall | Bill Wilson | 34 | 39 | -5 |
| 1973-04-18 | vs PHI | 9 | W 2-1 | 4-5 | 4 | 13,728 | Steve Renko | Steve Carlton | Steve Renko | Steve Carlton | | 36 | 40 | -4 |
| 1973-04-19 | vs PHI | 10 | W 6-5 | 5-5 | 4 | 12,359 | Mike Torrez | Larry Christenson | Mike Torrez | Larry Christenson | Tom Walker | 42 | 45 | -3 |
| 1973-04-21 | @ NYN | 11 | L 0-5 | 5-6 | 4 | 40,011 | Balor Moore | Harry Parker | Harry Parker | Balor Moore | Tug McGraw | 42 | 50 | -8 |
| 1973-04-22 | @ NYN | 12 | W 2-1 | 6-7 | 5 | 0 | John Strohmayer | Tom Seaver | Mike Marshall | Phil Hennigan | Tom Walker | 44 | 51 | -7 |
| 1973-04-22 | @ NYN | 13 | L 3-13 | 6-7 | 5 | 27,230 | Steve Renko | Jim McAndrew | Jim McAndrew | Steve Renko | George Stone | 47 | 64 | -17 |
| 1973-04-24 | @ CIN | 14 | W 7-2 | 7-7 | 4 | 9,539 | Mike Torrez | Don Gullett | Mike Torrez | Clay Carroll | Tom Walker | 54 | 66 | -12 |
| 1973-04-25 | @ CIN | 15 | L 4-7 | 7-8 | 4 | 8,149 | Balor Moore | Jack Billingham | Jack Billingham | Tom Walker | Pedro Borbon | 58 | 73 | -15 |
| 1973-04-27 | @ HOU | 16 | L 5-6 | 7-9 | 5 | 11,242 | Ernie McAnally | Dave Roberts | Jim York | Tom Walker | | 63 | 79 | -16 |
| 1973-04-28 | @ HOU | 17 | L 3-5 | 7-10 | 5 | 22,165 | Steve Renko | Ken Forsch | Fred Gladding | Steve Renko | Jim York | 66 | 84 | -18 |
| 1973-04-29 | @ HOU | 18 | L 3-4 | 7-11 | 5 | 10,539 | Mike Torrez | Don Wilson | Jim Ray | Mike Marshall | | 69 | 88 | -19 |
| 1973-05-01 | @ ATL | 19 | W 9-6 | 8-11 | 5 | 3,391 | Balor Moore | Gary Gentry | Mike Marshall | Phil Niekro | | 78 | 94 | -16 |
| 1973-05-02 | @ ATL | 20 | W 3-2 | 9-11 | 4 | 2,619 | Ernie McAnally | Pat Dobson | Ernie McAnally | Pat Dobson | | 81 | 96 | -15 |
| 1973-05-04 | vs CIN | 21 | W 6-3 | 10-11 | 4 | 10,665 | Mike Torrez | Jack Billingham | Mike Torrez | Jack Billingham | Steve Renko | 87 | 99 | -12 |
| 1973-05-05 | vs CIN | 22 | W 8-6 | 11-11 | 3 | 8,623 | Bill Stoneman | Don Gullett | Pat Jarvis | Clay Carroll | Joe Gilbert | 95 | 105 | -10 |
| 1973-05-06 | vs CIN | 23 | L 1-6 | 11-12 | 4 | 10,258 | Balor Moore | Roger Nelson | Roger Nelson | Balor Moore | | 96 | 111 | -15 |
| 1973-05-07 | vs HOU | 24 | L 0-6 | 11-13 | 4 | 7,021 | Ernie McAnally | Dave Roberts | Dave Roberts | Ernie McAnally | | 96 | 117 | -21 |
| 1973-05-08 | vs HOU | 25 | W 4-3 | 12-13 | 4 | 5,035 | Steve Renko | Ken Forsch | Steve Renko | Ken Forsch | | 100 | 120 | -20 |
| 1973-05-11 | @ SLN | 26 | L 0-12 | 12-14 | 4 | 13,089 | Mike Torrez | Alan Foster | Alan Foster | Mike Torrez | | 100 | 132 | -32 |
| 1973-05-12 | @ SLN | 27 | W 3-1 | 13-14 | 3 | 27,180 | Balor Moore | Jim Bibby | Balor Moore | Jim Bibby | Mike Marshall | 103 | 133 | -30 |
| 1973-05-13 | @ SLN | 28 | L 2-3 | 13-15 | 3 | 8,471 | Bill Stoneman | Bob Gibson | Bob Gibson | Bill Stoneman | Diego Segui | 105 | 136 | -31 |
| 1973-05-14 | @ PIT | 29 | W 3-2 | 14-15 | 3 | 6,327 | Steve Renko | Nelson Briles | Tom Walker | Nelson Briles | | 108 | 138 | -30 |
| 1973-05-15 | @ PIT | 30 | L 8-9 | 14-16 | 3 | 5,441 | Ernie McAnally | Steve Blass | Dave Giusti | Joe Gilbert | | 116 | 147 | -31 |
| 1973-05-16 | vs NYN | 31 | L 3-8 | 14-17 | 3 | 10,023 | Mike Torrez | Harry Parker | Harry Parker | Mike Torrez | Tug McGraw | 119 | 155 | -36 |
| 1973-05-20 | vs SLN | 32 | W 4-1 | 15-18 | 3 | 0 | Balor Moore | Bob Gibson | Balor Moore | Bob Gibson | Mike Marshall | 123 | 156 | -33 |
| 1973-05-20 | vs SLN | 33 | L 3-7 | 15-18 | 3 | 25,104 | Bill Stoneman | Reggie Cleveland | Reggie Cleveland | Bill Stoneman | Wayne Granger | 126 | 163 | -37 |
| 1973-05-22 | vs CHN | 34 | W 4-3 | 16-18 | 3 | 10,377 | Steve Renko | Fergie Jenkins | Mike Marshall | Jack Aker | | 130 | 166 | -36 |
| 1973-05-23 | vs CHN | 35 | L 2-4 | 16-19 | 3 | 11,318 | Ernie McAnally | Burt Hooton | Bill Bonham | Tom Walker | | 132 | 170 | -38 |
| 1973-05-25 | @ SFN | 36 | W 5-2 | 17-19 | 3 | 4,177 | Mike Torrez | Jim Barr | Mike Marshall | Jim Barr | | 137 | 172 | -35 |
| 1973-05-26 | @ SFN | 37 | L 3-10 | 17-20 | 3 | 5,038 | Balor Moore | Tom Bradley | Tom Bradley | Balor Moore | Elias Sosa | 140 | 182 | -42 |
| 1973-05-27 | @ SFN | 38 | L 3-6 | 17-21 | 3 | 9,613 | Steve Renko | Ron Bryant | Ron Bryant | Steve Renko | | 143 | 188 | -45 |
| 1973-05-28 | @ SDN | 39 | W 7-6 | 18-21 | 3 | 3,161 | Ernie McAnally | Mike Corkins | Mike Marshall | Gary Ross | Bill Stoneman | 150 | 194 | -44 |
| 1973-05-30 | @ SDN | 40 | W 5-3 | 19-22 | 4 | 0 | Bill Stoneman | Fred Norman | Bill Stoneman | Fred Norman | Mike Marshall | 155 | 197 | -42 |
| 1973-05-30 | @ SDN | 41 | L 2-3 | 19-22 | 4 | 5,566 | Mike Torrez | Mike Caldwell | Mike Caldwell | Mike Marshall | Rich Troedson | 157 | 200 | -43 |
| 1973-06-01 | @ LAN | 42 | L 2-3 | 19-23 | 4 | 22,480 | Balor Moore | Don Sutton | Don Sutton | Balor Moore | | 159 | 203 | -44 |
| 1973-06-02 | @ LAN | 43 | W 6-3 | 20-23 | 4 | 25,908 | Steve Renko | Andy Messersmith | Steve Renko | Andy Messersmith | Mike Marshall | 165 | 206 | -41 |
| 1973-06-03 | @ LAN | 44 | W 4-1 | 21-23 | 4 | 34,785 | Ernie McAnally | Al Downing | Ernie McAnally | Al Downing | | 169 | 207 | -38 |
| 1973-06-05 | vs ATL | 45 | W 7-6 | 22-23 | 3 | 14,092 | Bill Stoneman | Gary Gentry | Mike Marshall | Ron Schueler | | 176 | 213 | -37 |
| 1973-06-06 | vs ATL | 46 | L 3-5 | 22-24 | 4 | 15,107 | Mike Torrez | Phil Niekro | Phil Niekro | Mickey Scott | Danny Frisella | 179 | 218 | -39 |
| 1973-06-07 | vs ATL | 47 | L 2-3 | 22-25 | 4 | 11,071 | Balor Moore | Carl Morton | Carl Morton | Balor Moore | Roric Harrison | 181 | 221 | -40 |
| 1973-06-08 | vs SFN | 48 | W 17-3 | 23-25 | 2 | 15,137 | Steve Renko | Jim Barr | Steve Renko | Jim Barr | | 198 | 224 | -26 |
| 1973-06-09 | vs SFN | 49 | W 9-6 | 24-25 | 2 | 21,334 | Ernie McAnally | Tom Bradley | Tom Walker | Tom Bradley | Mike Marshall | 207 | 230 | -23 |
| 1973-06-10 | vs SFN | 50 | W 7-6 | 25-25 | 2 | 21,738 | Bill Stoneman | Jim Willoughby | Mike Marshall | Randy Moffitt | | 214 | 236 | -22 |
| 1973-06-12 | vs SDN | 51 | W 7-4 | 26-25 | 2 | 12,352 | Mike Torrez | Mike Caldwell | Mickey Scott | Mike Caldwell | Tom Walker | 221 | 240 | -19 |
| 1973-06-13 | vs SDN | 52 | W 3-2 | 27-25 | 2 | 20,152 | Balor Moore | Bill Greif | Balor Moore | Bill Greif | Mike Marshall | 224 | 242 | -18 |
| 1973-06-14 | vs SDN | 53 | W 5-3 | 28-25 | 2 | 11,522 | Steve Renko | Clay Kirby | Steve Renko | Gary Ross | | 229 | 245 | -16 |
| 1973-06-15 | vs LAN | 54 | W 4-3 | 29-25 | 2 | 15,493 | Ernie McAnally | Al Downing | Ernie McAnally | George Culver | Mike Marshall | 233 | 248 | -15 |
| 1973-06-16 | vs LAN | 55 | L 3-6 | 29-26 | 2 | 10,187 | Bill Stoneman | Claude Osteen | Claude Osteen | Bill Stoneman | | 236 | 254 | -18 |
| 1973-06-17 | vs LAN | 56 | L 2-3 | 29-27 | 2 | 25,664 | Mike Torrez | Don Sutton | Jim Brewer | Mike Marshall | | 238 | 257 | -19 |
| 1973-06-18 | @ SLN | 57 | L 0-1 | 29-28 | 2 | 12,893 | Balor Moore | Rick Wise | Rick Wise | Balor Moore | | 238 | 258 | -20 |
| 1973-06-19 | @ SLN | 58 | W 3-1 | 30-28 | 2 | 12,346 | Steve Renko | Tom Murphy | Steve Renko | Tom Murphy | Mike Marshall | 241 | 259 | -18 |
| 1973-06-20 | @ SLN | 59 | W 5-1 | 31-28 | 2 | 14,256 | Ernie McAnally | Alan Foster | Ernie McAnally | Alan Foster | Mike Marshall | 246 | 260 | -14 |
| 1973-06-21 | @ SLN | 60 | L 3-4 | 31-29 | 2 | 17,083 | Bill Stoneman | Bob Gibson | Bob Gibson | Bill Stoneman | | 249 | 264 | -15 |
| 1973-06-22 | vs PHI | 61 | W 4-2 | 32-29 | 2 | 11,707 | Mike Torrez | Steve Carlton | Mike Torrez | Steve Carlton | | 253 | 266 | -13 |
| 1973-06-23 | vs PHI | 62 | L 2-7 | 32-30 | 2 | 18,385 | Balor Moore | Ken Brett | Ken Brett | Balor Moore | | 255 | 273 | -18 |
| 1973-06-24 | vs PHI | 63 | L 4-5 | 32-31 | 2 | 17,776 | Steve Renko | Jim Lonborg | Jim Lonborg | Steve Renko | Bill Wilson | 259 | 278 | -19 |
| 1973-06-25 | vs PIT | 64 | L 6-8 | 32-33 | 2 | 0 | Ernie McAnally | Bob Johnson | Dave Giusti | Ernie McAnally | | 265 | 286 | -21 |
| 1973-06-25 | vs PIT | 65 | L 1-3 | 32-33 | 2 | 24,402 | John Strohmayer | Nelson Briles | Nelson Briles | John Strohmayer | | 266 | 289 | -23 |
| 1973-06-26 | vs PIT | 66 | W 10-3 | 33-33 | 2 | 12,806 | Bill Stoneman | Luke Walker | Bill Stoneman | Luke Walker | Mike Marshall | 276 | 292 | -16 |
| 1973-06-27 | @ CHN | 67 | L 1-6 | 34-34 | 2 | 0 | Balor Moore | Fergie Jenkins | Fergie Jenkins | Balor Moore | Bill Bonham | 277 | 298 | -21 |
| 1973-06-27 | @ CHN | 68 | W 5-4 | 34-34 | 2 | 32,238 | Mike Torrez | Larry Gura | Bill Stoneman | Burt Hooton | | 282 | 302 | -20 |
| 1973-06-28 | @ CHN | 69 | L 2-4 | 34-35 | 2 | 17,617 | Steve Renko | Milt Pappas | Milt Pappas | Steve Renko | Dave LaRoche | 284 | 306 | -22 |
| 1973-06-29 | @ PIT | 70 | L 0-4 | 34-36 | 3 | 26,638 | Ernie McAnally | Bob Moose | Bob Moose | Ernie McAnally | | 284 | 310 | -26 |
| 1973-06-30 | @ PIT | 71 | L 1-5 | 34-37 | 3 | 11,676 | Balor Moore | Nelson Briles | Nelson Briles | Balor Moore | Ramon Hernandez | 285 | 315 | -30 |
| 1973-07-01 | @ PIT | 72 | L 2-6 | 34-39 | 5 | 0 | Bill Stoneman | Luke Walker | Luke Walker | Bill Stoneman | Bob Johnson | 287 | 321 | -34 |
| 1973-07-01 | @ PIT | 73 | L 4-8 | 34-39 | 5 | 24,984 | Mike Torrez | Jim Rooker | Jim Rooker | Mike Torrez | Dave Giusti | 291 | 329 | -38 |
| 1973-07-02 | vs NYN | 74 | W 2-1 | 35-39 | 4 | 14,618 | Steve Renko | George Stone | Steve Renko | Buzz Capra | | 293 | 330 | -37 |
| 1973-07-03 | vs NYN | 75 | W 19-8 | 36-39 | 3 | 12,279 | Ernie McAnally | Jim McAndrew | Ernie McAnally | Jim McAndrew | Mike Marshall | 312 | 338 | -26 |
| 1973-07-04 | vs NYN | 76 | W 7-5 | 37-39 | 3 | 15,801 | Balor Moore | Tom Seaver | Joe Gilbert | Buzz Capra | Mike Marshall | 319 | 343 | -24 |
| 1973-07-05 | vs NYN | 77 | L 3-7 | 37-40 | 3 | 15,628 | Bill Stoneman | Jon Matlack | Jon Matlack | Mickey Scott | Tug McGraw | 322 | 350 | -28 |
| 1973-07-06 | vs HOU | 78 | W 12-8 | 39-40 | 3 | 0 | John Strohmayer | Jerry Reuss | Pat Jarvis | Jim Ray | Mike Marshall | 334 | 358 | -24 |
| 1973-07-06 | vs HOU | 79 | W 14-6 | 39-40 | 3 | 17,653 | Mike Torrez | Tom Griffin | Mike Torrez | Tom Griffin | Mike Marshall | 348 | 364 | -16 |
| 1973-07-07 | vs HOU | 80 | W 6-1 | 40-40 | 3 | 23,693 | Steve Renko | Dave Roberts | Steve Renko | Dave Roberts | | 354 | 365 | -11 |
| 1973-07-08 | vs HOU | 81 | L 7-9 | 40-41 | 3 | 20,129 | Ernie McAnally | Ken Forsch | Jerry Reuss | Mike Marshall | | 361 | 374 | -13 |
| 1973-07-09 | vs CIN | 82 | L 6-11 | 40-42 | 3 | 27,324 | Bill Stoneman | Tom Hall | Ed Sprague | Joe Gilbert | Clay Carroll | 367 | 385 | -18 |
| 1973-07-10 | vs CIN | 83 | L 2-6 | 40-42 | 3 | 17,094 | Mike Torrez | Ross Grimsley | Ross Grimsley | Mike Torrez | Don Gullett | 369 | 391 | -22 |
| 1973-07-11 | vs CIN | 84 | W 4-3 | 41-42 | 3 | 20,037 | Steve Renko | Fred Norman | Steve Renko | Fred Norman | Mike Marshall | 373 | 394 | -21 |
| 1973-07-13 | @ ATL | 85 | W 11-7 | 42-42 | 3 | 0 | Bill Stoneman | Phil Niekro | Bill Stoneman | Jim Panther | Mike Marshall | 384 | 401 | -17 |
| 1973-07-13 | @ ATL | 86 | L 6-15 | 42-42 | 3 | 15,126 | Ernie McAnally | Carl Morton | Carl Morton | Ernie McAnally | Adrian Devine | 390 | 416 | -26 |
| 1973-07-14 | @ ATL | 87 | L 1-4 | 42-42 | 3 | 11,511 | Balor Moore | Roric Harrison | Roric Harrison | Balor Moore | Gary Gentry | 391 | 420 | -29 |
| 1973-07-15 | @ ATL | 88 | L 1-6 | 42-42 | 3 | 8,620 | Mike Torrez | Ron Schueler | Ron Schueler | Mike Torrez | | 392 | 426 | -34 |
| 1973-07-16 | @ HOU | 89 | L 5-6 | 42-43 | 3 | 16,186 | Steve Renko | Ken Forsch | Cecil Upshaw | Tom Walker | | 397 | 432 | -35 |
| 1973-07-17 | @ HOU | 90 | W 7-2 | 43-43 | 3 | 18,156 | Ernie McAnally | Don Wilson | Ernie McAnally | Don Wilson | Mike Marshall | 404 | 434 | -30 |
| 1973-07-18 | @ HOU | 91 | W 3-2 | 44-43 | 3 | 14,352 | Steve Rogers | Jerry Reuss | Mike Marshall | Cecil Upshaw | | 407 | 436 | -29 |
| 1973-07-19 | @ CIN | 92 | L 2-3 | 44-44 | 3 | 16,441 | Bill Stoneman | Ross Grimsley | Ross Grimsley | Bill Stoneman | Pedro Borbon | 409 | 439 | -30 |
| 1973-07-20 | @ CIN | 93 | L 0-4 | 44-45 | 3 | 34,058 | Mike Torrez | Fred Norman | Fred Norman | Mike Torrez | Pedro Borbon | 409 | 443 | -34 |
| 1973-07-21 | @ CIN | 94 | L 4-6 | 44-46 | 3 | 30,069 | Steve Renko | Roger Nelson | Don Gullett | Steve Renko | Clay Carroll | 413 | 449 | -36 |
| 1973-07-22 | @ CIN | 95 | L 0-6 | 44-47 | 4 | 22,107 | Ernie McAnally | Jack Billingham | Jack Billingham | Ernie McAnally | | 413 | 455 | -42 |
| 1973-07-26 | @ PHI | 96 | W 4-0 | 46-47 | 3 | 0 | Steve Rogers | Steve Carlton | Steve Rogers | Steve Carlton | | 417 | 455 | -38 |
| 1973-07-26 | @ PHI | 97 | W 5-1 | 46-47 | 3 | 34,459 | Steve Renko | Ken Brett | Steve Renko | Ken Brett | Mike Marshall | 422 | 456 | -34 |
| 1973-07-27 | @ PHI | 98 | W 5-4 | 47-47 | 3 | 18,254 | Ernie McAnally | Jim Lonborg | Tom Walker | Bucky Brandon | Mike Marshall | 427 | 460 | -33 |
| 1973-07-28 | @ NYN | 99 | L 3-11 | 47-48 | 3 | 26,600 | Mike Torrez | George Stone | George Stone | Mike Torrez | | 430 | 471 | -41 |
| 1973-07-29 | @ NYN | 100 | W 6-4 | 48-48 | 3 | 28,205 | Craig Caskey | Ray Sadecki | Mike Marshall | Ray Sadecki | | 436 | 475 | -39 |
| 1973-07-30 | @ NYN | 101 | W 1-0 | 50-48 | 3 | 0 | Steve Rogers | Jon Matlack | Steve Rogers | Jon Matlack | | 437 | 475 | -38 |
| 1973-07-30 | @ NYN | 102 | W 5-2 | 50-48 | 3 | 25,960 | Steve Renko | Tug McGraw | Mike Marshall | Buzz Capra | | 442 | 477 | -35 |
| 1973-07-31 | vs SLN | 103 | L 5-10 | 50-49 | 3 | 22,024 | Ernie McAnally | Alan Foster | Alan Foster | Ernie McAnally | Al Hrabosky | 447 | 487 | -40 |
| 1973-08-01 | vs SLN | 104 | L 3-9 | 50-51 | 3 | 0 | Bill Stoneman | Rick Wise | Rick Wise | Bill Stoneman | | 450 | 496 | -46 |
| 1973-08-01 | vs SLN | 105 | L 0-2 | 50-51 | 3 | 20,214 | Mike Torrez | Reggie Cleveland | Reggie Cleveland | Mike Torrez | | 450 | 498 | -48 |
| 1973-08-02 | vs SLN | 106 | W 2-0 | 51-51 | 3 | 13,215 | Balor Moore | Tom Murphy | Balor Moore | Tom Murphy | | 452 | 498 | -46 |
| 1973-08-03 | vs CHN | 107 | L 0-3 | 51-52 | 3 | 18,223 | Steve Renko | Rick Reuschel | Rick Reuschel | Steve Renko | | 452 | 501 | -49 |
| 1973-08-04 | vs CHN | 108 | W 6-1 | 52-52 | 3 | 25,037 | Steve Rogers | Fergie Jenkins | Steve Rogers | Fergie Jenkins | | 458 | 502 | -44 |
| 1973-08-05 | vs CHN | 109 | W 3-2 | 53-52 | 2 | 31,019 | Mike Torrez | Burt Hooton | Mike Torrez | Burt Hooton | Mike Marshall | 461 | 504 | -43 |
| 1973-08-06 | vs CHN | 110 | W 7-3 | 54-52 | 2 | 16,101 | Balor Moore | Bill Bonham | Balor Moore | Bill Bonham | Mike Marshall | 468 | 507 | -39 |
| 1973-08-07 | @ SFN | 111 | W 2-1 | 55-52 | 2 | 3,668 | Steve Renko | Tom Bradley | Steve Renko | Tom Bradley | | 470 | 508 | -38 |
| 1973-08-08 | @ SFN | 112 | L 1-2 | 55-53 | 2 | 3,674 | Steve Rogers | Ron Bryant | Ron Bryant | Steve Rogers | Elias Sosa | 471 | 510 | -39 |
| 1973-08-09 | @ SFN | 113 | W 5-3 | 56-53 | 2 | 3,471 | Mike Torrez | Jim Barr | Mike Torrez | Jim Barr | Mike Marshall | 476 | 513 | -37 |
| 1973-08-10 | @ SDN | 114 | L 3-4 | 56-54 | 2 | 4,842 | Balor Moore | Steve Arlin | Steve Arlin | Balor Moore | Mike Caldwell | 479 | 517 | -38 |
| 1973-08-12 | @ SDN | 115 | W 2-0 | 57-55 | 2 | 0 | Steve Rogers | Clay Kirby | Steve Rogers | Clay Kirby | Mike Marshall | 481 | 517 | -36 |
| 1973-08-12 | @ SDN | 116 | L 3-4 | 57-55 | 2 | 5,617 | Steve Renko | Rich Troedson | Mike Caldwell | Mike Marshall | | 484 | 521 | -37 |
| 1973-08-13 | @ LAN | 117 | L 5-8 | 57-56 | 2 | 21,437 | Mike Torrez | Claude Osteen | Claude Osteen | Pat Jarvis | Jim Brewer | 489 | 529 | -40 |
| 1973-08-14 | @ LAN | 118 | L 3-4 | 57-57 | 2 | 23,448 | Balor Moore | Tommy John | Doug Rau | Balor Moore | | 492 | 533 | -41 |
| 1973-08-15 | @ LAN | 119 | L 2-7 | 57-58 | 2 | 25,982 | Ernie McAnally | Don Sutton | Don Sutton | Ernie McAnally | Jim Brewer | 494 | 540 | -46 |
| 1973-08-17 | vs ATL | 120 | W 8-7 | 58-58 | 2 | 23,821 | Steve Renko | Ron Schueler | Tom Walker | Danny Frisella | | 502 | 547 | -45 |
| 1973-08-18 | vs ATL | 121 | L 1-3 | 58-59 | 2 | 25,093 | Steve Rogers | Carl Morton | Carl Morton | Steve Rogers | Joe Niekro | 503 | 550 | -47 |
| 1973-08-19 | vs ATL | 122 | W 3-1 | 59-59 | 2 | 21,886 | Balor Moore | Phil Niekro | Balor Moore | Phil Niekro | Mike Marshall | 506 | 551 | -45 |
| 1973-08-20 | vs SFN | 123 | L 4-6 | 59-60 | 2 | 17,439 | Mike Torrez | Tom Bradley | Don McMahon | Tom Walker | | 510 | 557 | -47 |
| 1973-08-21 | vs SFN | 124 | L 1-3 | 59-61 | 3 | 16,137 | Steve Renko | Ron Bryant | Ron Bryant | Steve Renko | | 511 | 560 | -49 |
| 1973-08-22 | vs SFN | 125 | L 2-3 | 59-62 | 3 | 19,176 | Steve Rogers | Jim Barr | Jim Barr | Steve Rogers | Elias Sosa | 513 | 563 | -50 |
| 1973-08-24 | vs SDN | 126 | L 3-5 | 59-63 | 3 | 14,161 | Balor Moore | Rich Troedson | Rich Troedson | Balor Moore | Mike Caldwell | 516 | 568 | -52 |
| 1973-08-25 | vs SDN | 127 | W 13-3 | 60-63 | 3 | 16,183 | Mike Torrez | Bill Greif | Mike Torrez | Bill Greif | | 529 | 571 | -42 |
| 1973-08-26 | vs SDN | 128 | L 2-4 | 60-64 | 4 | 14,129 | Steve Renko | Randy Jones | Randy Jones | Steve Renko | | 531 | 575 | -44 |
| 1973-08-27 | vs LAN | 129 | W 4-0 | 61-64 | 4 | 20,098 | Steve Rogers | Andy Messersmith | Steve Rogers | Andy Messersmith | | 535 | 575 | -40 |
| 1973-08-28 | vs LAN | 130 | L 1-6 | 61-65 | 4 | 19,131 | Balor Moore | Claude Osteen | Claude Osteen | Balor Moore | | 536 | 581 | -45 |
| 1973-08-29 | vs LAN | 131 | W 6-5 | 62-65 | 4 | 14,178 | Mike Torrez | Tommy John | Tom Walker | Jim Brewer | | 542 | 586 | -44 |
| 1973-08-30 | @ PHI | 132 | L 7-8 | 62-66 | 4 | 10,220 | Steve Renko | Steve Carlton | George Culver | Mike Marshall | | 549 | 594 | -45 |
| 1973-08-31 | @ PHI | 133 | W 5-2 | 63-66 | 3 | 14,171 | Steve Rogers | Jim Lonborg | Steve Rogers | Jim Lonborg | Mike Marshall | 554 | 596 | -42 |
| 1973-09-01 | @ PHI | 134 | W 11-5 | 64-66 | 3 | 14,217 | Balor Moore | Wayne Twitchell | Mike Marshall | Wayne Twitchell | | 565 | 601 | -36 |
| 1973-09-02 | @ PHI | 135 | W 12-0 | 65-66 | 3 | 10,427 | Mike Torrez | Ken Brett | Mike Torrez | Ken Brett | | 577 | 601 | -24 |
| 1973-09-03 | vs CHN | 136 | W 5-2 | 66-66 | 2 | 20,165 | Steve Renko | Milt Pappas | Steve Renko | Milt Pappas | Mike Marshall | 582 | 603 | -21 |
| 1973-09-04 | vs CHN | 137 | W 3-2 | 67-66 | 2 | 18,667 | Steve Rogers | Fergie Jenkins | Steve Rogers | Fergie Jenkins | Mike Marshall | 585 | 605 | -20 |
| 1973-09-06 | vs CHN | 138 | W 5-3 | 68-66 | 2 | 9,306 | Balor Moore | Rick Reuschel | Chuck Taylor | Rick Reuschel | | 590 | 608 | -18 |
| 1973-09-07 | vs NYN | 139 | L 0-1 | 68-68 | 2 | 0 | Steve Renko | Jon Matlack | Jon Matlack | Steve Renko | Tug McGraw | 590 | 609 | -19 |
| 1973-09-07 | vs NYN | 140 | L 2-4 | 68-68 | 2 | 24,167 | Mike Torrez | Jerry Koosman | Tug McGraw | Mike Marshall | Ray Sadecki | 592 | 613 | -21 |
| 1973-09-08 | vs NYN | 141 | W 3-1 | 69-68 | 2 | 17,632 | Steve Rogers | Tom Seaver | Steve Rogers | Tom Seaver | | 595 | 614 | -19 |
| 1973-09-09 | vs NYN | 142 | L 0-3 | 69-69 | 2 | 20,743 | Balor Moore | George Stone | George Stone | Balor Moore | Tug McGraw | 595 | 617 | -22 |
| 1973-09-11 | @ SLN | 143 | W 4-1 | 70-69 | 1 | 13,610 | Steve Renko | Alan Foster | Steve Renko | Alan Foster | Mike Marshall | 599 | 618 | -19 |
| 1973-09-12 | @ SLN | 144 | W 2-1 | 71-69 | 1 | 13,121 | Steve Rogers | Rick Wise | Steve Rogers | Rick Wise | | 601 | 619 | -18 |
| 1973-09-14 | vs PHI | 145 | W 3-2 | 72-69 | 1 | 13,458 | Balor Moore | Steve Carlton | Chuck Taylor | Steve Carlton | | 604 | 621 | -17 |
| 1973-09-15 | vs PHI | 146 | W 5-4 | 73-69 | 1 | 34,331 | Mike Torrez | Dick Ruthven | Tom Walker | Mac Scarce | | 609 | 625 | -16 |
| 1973-09-16 | vs PHI | 147 | W 4-2 | 74-69 | 1 | 18,122 | Steve Renko | Jim Lonborg | Steve Renko | Jim Lonborg | | 613 | 627 | -14 |
| 1973-09-17 | vs SLN | 148 | W 5-4 | 75-70 | 1 | 0 | Steve Rogers | Rick Wise | Mike Marshall | Al Hrabosky | | 618 | 631 | -13 |
| 1973-09-17 | vs SLN | 149 | L 3-5 | 75-70 | 1 | 20,160 | Bill Stoneman | Rich Folkers | Eddie Fisher | Mike Marshall | | 621 | 636 | -15 |
| 1973-09-18 | vs SLN | 150 | L 4-7 | 75-71 | 1 | 7,679 | Balor Moore | Reggie Cleveland | Orlando Pena | Balor Moore | | 625 | 643 | -18 |
| 1973-09-19 | @ CHN | 151 | L 6-8 | 75-72 | 1 | 2,568 | Mike Torrez | Rick Reuschel | Rick Reuschel | Mike Marshall | Bob Locker | 631 | 651 | -20 |
| 1973-09-20 | @ CHN | 152 | L 4-5 | 75-73 | 1 | 1,957 | Steve Renko | Fergie Jenkins | Fergie Jenkins | Steve Renko | Bob Locker | 635 | 656 | -21 |
| 1973-09-21 | @ CHN | 153 | L 1-3 | 75-74 | 1 | 2,540 | Steve Rogers | Burt Hooton | Burt Hooton | Steve Rogers | Bob Locker | 636 | 659 | -23 |
| 1973-09-23 | vs PIT | 154 | L 3-6 | 75-76 | 3 | 0 | Bill Stoneman | Bruce Kison | Bruce Kison | Bill Stoneman | Ramon Hernandez | 639 | 665 | -26 |
| 1973-09-23 | vs PIT | 155 | L 4-7 | 75-76 | 3 | 26,178 | Mike Torrez | Dock Ellis | Dock Ellis | Mike Torrez | Dave Giusti | 643 | 672 | -29 |
| 1973-09-24 | vs PIT | 156 | W 5-4 | 76-77 | 3 | 0 | Steve Renko | Bob Moose | Steve Renko | Bob Moose | Mike Marshall | 648 | 676 | -28 |
| 1973-09-24 | vs PIT | 157 | L 0-3 | 76-77 | 3 | 20,168 | Ernie McAnally | Nelson Briles | Nelson Briles | Ernie McAnally | Dave Giusti | 648 | 679 | -31 |
| 1973-09-25 | @ NYN | 158 | L 1-2 | 76-78 | 3 | 43,805 | Steve Rogers | Jerry Koosman | Jerry Koosman | Steve Rogers | Tug McGraw | 649 | 681 | -32 |
| 1973-09-26 | @ NYN | 159 | W 8-5 | 77-78 | 3 | 30,953 | Balor Moore | Tom Seaver | Mike Marshall | Harry Parker | | 657 | 686 | -29 |
| 1973-09-28 | @ PIT | 160 | W 3-2 | 78-78 | 2 | 27,804 | Steve Renko | Dock Ellis | Mike Marshall | Dock Ellis | | 660 | 688 | -28 |
| 1973-09-29 | @ PIT | 161 | W 6-4 | 79-78 | 2 | 9,816 | Steve Rogers | Nelson Briles | Steve Rogers | Jim McKee | Mike Marshall | 666 | 692 | -26 |
| 1973-09-30 | @ PIT | 162 | L 2-10 | 79-79 | 2 | 33,376 | Ernie McAnally | Jim Rooker | Jim Rooker | Ernie McAnally | | 668 | 702 | -34 |