| 1972-04-15 | @ DET | 1 | L 2-3 | 0-1 | 4 | 31,510 | Marty Pattin | Mickey Lolich | Mickey Lolich | Marty Pattin | | 2 | 3 | -1 |
| 1972-04-17 | vs CLE | 2 | L 0-4 | 0-2 | 5 | 24,989 | Ray Culp | Milt Wilcox | Milt Wilcox | Ray Culp | | 2 | 7 | -5 |
| 1972-04-18 | vs CLE | 3 | W 4-2 | 1-2 | 4 | 8,231 | Sonny Siebert | Dick Tidrow | Sonny Siebert | Dick Tidrow | Ken Tatum | 6 | 9 | -3 |
| 1972-04-19 | vs CLE | 4 | L 1-3 | 1-3 | 6 | 9,735 | Marty Pattin | Gaylord Perry | Gaylord Perry | Marty Pattin | Steve Mingori | 7 | 12 | -5 |
| 1972-04-21 | vs NYA | 5 | W 5-4 | 2-3 | 3 | 14,895 | Ray Culp | Mel Stottlemyre | Ray Culp | Mel Stottlemyre | Bill Lee | 12 | 16 | -4 |
| 1972-04-22 | vs NYA | 6 | W 11-7 | 3-3 | 3 | 11,162 | Sonny Siebert | Fritz Peterson | Sonny Siebert | Fritz Peterson | Lew Krausse | 23 | 23 | 0 |
| 1972-04-25 | @ MIN | 7 | L 0-12 | 3-4 | 4 | 4,425 | Marty Pattin | Jim Perry | Jim Perry | Marty Pattin | | 23 | 35 | -12 |
| 1972-04-26 | @ MIN | 8 | L 1-3 | 3-5 | 4 | 4,368 | Ray Culp | Dick Woodson | Dick Woodson | Ray Culp | Dave LaRoche | 24 | 38 | -14 |
| 1972-04-28 | @ TEX | 9 | L 6-9 | 3-6 | 4 | 9,974 | Sonny Siebert | Pete Broberg | Paul Lindblad | Bill Lee | Horacio Pina | 30 | 47 | -17 |
| 1972-04-29 | @ TEX | 10 | L 6-7 | 3-7 | 4 | 9,531 | Luis Tiant | Bill Gogolewski | Casey Cox | Bobby Bolin | | 36 | 54 | -18 |
| 1972-04-30 | @ TEX | 11 | W 3-0 | 4-7 | 4 | 8,556 | Lew Krausse | Jim Shellenback | Lew Krausse | Jim Panther | Bill Lee | 39 | 54 | -15 |
| 1972-05-05 | vs MIN | 12 | L 2-5 | 4-8 | 5 | 13,208 | Ray Culp | Jim Kaat | Jim Kaat | Ray Culp | Wayne Granger | 41 | 59 | -18 |
| 1972-05-06 | vs MIN | 13 | L 2-3 | 4-9 | 5 | 13,799 | Sonny Siebert | Jim Perry | Jim Perry | Sonny Siebert | Dave LaRoche | 43 | 62 | -19 |
| 1972-05-07 | vs MIN | 14 | L 4-8 | 4-10 | 5 | 11,747 | Luis Tiant | Dick Woodson | Dick Woodson | Luis Tiant | Wayne Granger | 47 | 70 | -23 |
| 1972-05-09 | @ CAL | 15 | W 4-3 | 5-10 | 4 | 5,414 | Lew Krausse | Clyde Wright | Bill Lee | Lloyd Allen | Ken Tatum | 51 | 73 | -22 |
| 1972-05-10 | @ CAL | 16 | L 1-5 | 5-11 | 5 | 5,170 | Marty Pattin | Nolan Ryan | Eddie Fisher | Marty Pattin | | 52 | 78 | -26 |
| 1972-05-11 | @ CAL | 17 | W 8-1 | 6-11 | 4 | 5,262 | Ray Culp | Andy Messersmith | Ray Culp | Andy Messersmith | | 60 | 79 | -19 |
| 1972-05-12 | @ OAK | 18 | W 7-6 | 7-11 | 4 | 8,147 | Sonny Siebert | Denny McLain | Bill Lee | Rollie Fingers | Ken Tatum | 67 | 85 | -18 |
| 1972-05-13 | @ OAK | 19 | W 9-6 | 8-11 | 4 | 20,567 | Lew Krausse | Ken Holtzman | Gary Peters | Ken Holtzman | | 76 | 91 | -15 |
| 1972-05-14 | @ OAK | 20 | L 5-6 | 8-12 | 4 | 9,734 | Marty Pattin | Catfish Hunter | Bob Locker | Ken Tatum | | 81 | 97 | -16 |
| 1972-05-16 | @ MIL | 21 | W 5-1 | 9-12 | 4 | 8,423 | Ray Culp | Ken Brett | Ray Culp | Ken Sanders | | 86 | 98 | -12 |
| 1972-05-17 | @ MIL | 22 | L 1-4 | 9-13 | 4 | 4,935 | Sonny Siebert | Jim Lonborg | Jim Lonborg | Sonny Siebert | Ken Sanders | 87 | 102 | -15 |
| 1972-05-18 | @ DET | 23 | L 2-7 | 9-14 | 4 | 7,770 | Lew Krausse | Joe Coleman | Joe Coleman | Lew Krausse | | 89 | 109 | -20 |
| 1972-05-19 | @ NYA | 24 | L 0-6 | 9-15 | 5 | 9,604 | Marty Pattin | Mel Stottlemyre | Mel Stottlemyre | Marty Pattin | | 89 | 115 | -26 |
| 1972-05-21 | @ NYA | 25 | L 3-6 | 9-17 | 5 | 0 | Ray Culp | Fritz Peterson | Fritz Peterson | Ray Culp | Sparky Lyle | 92 | 121 | -29 |
| 1972-05-21 | @ NYA | 26 | L 2-3 | 9-17 | 5 | 23,287 | Gary Peters | Mike Kekich | Mike Kekich | Gary Peters | Sparky Lyle | 94 | 124 | -30 |
| 1972-05-23 | vs BAL | 27 | W 6-5 | 10-17 | 5 | 14,552 | Sonny Siebert | Dave McNally | Bill Lee | Doyle Alexander | | 100 | 129 | -29 |
| 1972-05-24 | vs BAL | 28 | L 1-4 | 10-18 | 5 | 14,384 | Lew Krausse | Jim Palmer | Doyle Alexander | Lew Krausse | | 101 | 133 | -32 |
| 1972-05-25 | vs BAL | 29 | W 2-1 | 11-18 | 5 | 12,291 | Marty Pattin | Pat Dobson | Marty Pattin | Pat Dobson | | 103 | 134 | -31 |
| 1972-05-26 | vs MIL | 30 | W 5-4 | 12-18 | 5 | 16,340 | Ray Culp | Ken Brett | Bill Lee | Ken Sanders | | 108 | 138 | -30 |
| 1972-05-27 | vs MIL | 31 | W 9-3 | 13-18 | 5 | 17,332 | Sonny Siebert | Jim Slaton | Sonny Siebert | Jim Slaton | Ken Tatum | 117 | 141 | -24 |
| 1972-05-28 | vs MIL | 32 | W 4-1 | 14-18 | 4 | 18,356 | Lew Krausse | Jim Lonborg | John Curtis | Jim Lonborg | | 121 | 142 | -21 |
| 1972-05-29 | vs MIL | 33 | L 3-11 | 14-19 | 5 | 15,486 | Marty Pattin | Bill Parsons | Bill Parsons | Marty Pattin | | 124 | 153 | -29 |
| 1972-05-30 | @ BAL | 34 | W 6-0 | 15-19 | 5 | 7,216 | Ray Culp | Mike Cuellar | Ray Culp | Mike Cuellar | | 130 | 153 | -23 |
| 1972-06-01 | @ BAL | 35 | W 7-1 | 16-19 | 4 | 6,691 | Sonny Siebert | Dave McNally | Sonny Siebert | Dave McNally | | 137 | 154 | -17 |
| 1972-06-02 | @ KCA | 36 | L 1-9 | 16-20 | 4 | 9,240 | Lew Krausse | Dick Drago | Dick Drago | Lew Krausse | | 138 | 163 | -25 |
| 1972-06-03 | @ KCA | 37 | L 4-10 | 16-21 | 5 | 7,441 | Marty Pattin | Paul Splittorff | Tom Murphy | Marty Pattin | Tom Burgmeier | 142 | 173 | -31 |
| 1972-06-04 | @ KCA | 38 | L 5-7 | 17-22 | 4 | 0 | Ray Culp | Jim Rooker | Al Fitzmorris | Ray Culp | Tom Burgmeier | 147 | 180 | -33 |
| 1972-06-04 | @ KCA | 39 | W 4-0 | 17-22 | 4 | 11,920 | John Curtis | Mike Hedlund | John Curtis | Mike Hedlund | | 151 | 180 | -29 |
| 1972-06-06 | @ CHA | 40 | W 2-0 | 18-22 | 4 | 17,073 | Sonny Siebert | Wilbur Wood | Sonny Siebert | Wilbur Wood | | 153 | 180 | -27 |
| 1972-06-07 | @ CHA | 41 | L 1-2 | 18-23 | 4 | 11,857 | Luis Tiant | Stan Bahnsen | Stan Bahnsen | Luis Tiant | Rich Gossage | 154 | 182 | -28 |
| 1972-06-09 | vs CAL | 42 | W 6-5 | 19-23 | 4 | 16,757 | Marty Pattin | Rickey Clark | Marty Pattin | Eddie Fisher | | 160 | 187 | -27 |
| 1972-06-10 | vs CAL | 43 | L 3-7 | 19-24 | 4 | 21,682 | John Curtis | Clyde Wright | Clyde Wright | John Curtis | Lloyd Allen | 163 | 194 | -31 |
| 1972-06-11 | vs CAL | 44 | W 8-4 | 20-24 | 4 | 15,821 | Sonny Siebert | Nolan Ryan | Sonny Siebert | Eddie Fisher | Bill Lee | 171 | 198 | -27 |
| 1972-06-13 | vs KCA | 45 | L 2-4 | 20-25 | 4 | 12,121 | Marty Pattin | Paul Splittorff | Bruce Dal Canton | Bill Lee | Tom Burgmeier | 173 | 202 | -29 |
| 1972-06-14 | vs KCA | 46 | W 11-3 | 21-25 | 4 | 10,696 | John Curtis | Jim Rooker | John Curtis | Jim Rooker | | 184 | 205 | -21 |
| 1972-06-15 | vs KCA | 47 | L 9-13 | 21-26 | 4 | 11,127 | Sonny Siebert | Tom Murphy | Tom Murphy | Sonny Siebert | Bruce Dal Canton | 193 | 218 | -25 |
| 1972-06-17 | vs CHA | 48 | L 4-5 | 22-27 | 5 | 14,638 | Ray Culp | Wilbur Wood | Wilbur Wood | Ray Culp | Terry Forster | 197 | 223 | -26 |
| 1972-06-17 | vs CHA | 49 | W 10-8 | 22-27 | 5 | 16,066 | Marty Pattin | Tom Bradley | Bill Lee | Phil Regan | Don Newhauser | 207 | 231 | -24 |
| 1972-06-18 | vs CHA | 50 | L 4-8 | 22-28 | 5 | 19,311 | John Curtis | Stan Bahnsen | Stan Bahnsen | John Curtis | Vicente Romo | 211 | 239 | -28 |
| 1972-06-19 | vs TEX | 51 | W 12-0 | 23-28 | 4 | 8,860 | Sonny Siebert | Pete Broberg | Sonny Siebert | Pete Broberg | | 223 | 239 | -16 |
| 1972-06-20 | vs TEX | 52 | L 2-5 | 23-29 | 4 | 12,864 | Marty Pattin | Rich Hand | Rich Hand | Marty Pattin | Horacio Pina | 225 | 244 | -19 |
| 1972-06-21 | vs TEX | 53 | W 10-9 | 24-29 | 4 | 15,325 | Ray Culp | Bill Gogolewski | Luis Tiant | Horacio Pina | | 235 | 253 | -18 |
| 1972-06-23 | @ MIL | 54 | L 1-8 | 24-30 | 4 | 20,865 | John Curtis | Ken Brett | Ken Brett | John Curtis | Ken Sanders | 236 | 261 | -25 |
| 1972-06-24 | @ MIL | 55 | L 2-5 | 24-31 | 4 | 10,994 | Sonny Siebert | Jim Lonborg | Jim Lonborg | Sonny Siebert | | 238 | 266 | -28 |
| 1972-06-25 | @ MIL | 56 | W 8-1 | 25-32 | 5 | 0 | Marty Pattin | Bill Parsons | Marty Pattin | Bill Parsons | | 246 | 267 | -21 |
| 1972-06-25 | @ MIL | 57 | L 0-2 | 25-32 | 5 | 12,963 | Lynn McGlothen | Earl Stephenson | Earl Stephenson | Lynn McGlothen | Ken Sanders | 246 | 269 | -23 |
| 1972-06-26 | @ CLE | 58 | L 3-7 | 25-33 | 5 | 34,370 | Ray Culp | Ray Lamb | Ray Lamb | Ray Culp | Phil Hennigan | 249 | 276 | -27 |
| 1972-06-27 | @ CLE | 59 | W 8-2 | 26-33 | 4 | 24,112 | John Curtis | Vince Colbert | John Curtis | Vince Colbert | | 257 | 278 | -21 |
| 1972-06-28 | vs DET | 60 | W 5-3 | 27-33 | 3 | 16,822 | Sonny Siebert | Joe Coleman | Luis Tiant | Joe Coleman | | 262 | 281 | -19 |
| 1972-06-29 | vs DET | 61 | L 4-8 | 27-34 | 3 | 17,775 | Lynn McGlothen | Tom Timmermann | Fred Scherman | Don Newhauser | Chuck Seelbach | 266 | 289 | -23 |
| 1972-07-01 | vs MIL | 62 | W 5-4 | 28-34 | 4 | 17,691 | Marty Pattin | Bill Parsons | Marty Pattin | Bill Parsons | Luis Tiant | 271 | 293 | -22 |
| 1972-07-02 | vs MIL | 63 | W 15-4 | 30-34 | 4 | 0 | Ray Culp | Skip Lockwood | Ray Culp | Skip Lockwood | | 286 | 297 | -11 |
| 1972-07-02 | vs MIL | 64 | W 3-2 | 30-34 | 4 | 20,478 | John Curtis | Gary Ryerson | John Curtis | Frank Linzy | | 289 | 299 | -10 |
| 1972-07-03 | vs MIN | 65 | W 8-2 | 31-34 | 3 | 13,460 | Luis Tiant | Bert Blyleven | Luis Tiant | Bert Blyleven | | 297 | 301 | -4 |
| 1972-07-04 | vs MIN | 66 | W 2-0 | 32-34 | 3 | 16,356 | Lynn McGlothen | Ray Corbin | Lynn McGlothen | Ray Corbin | | 299 | 301 | -2 |
| 1972-07-05 | vs MIN | 67 | W 2-0 | 33-34 | 3 | 12,641 | Marty Pattin | Jim Perry | Marty Pattin | Jim Perry | | 301 | 301 | 0 |
| 1972-07-07 | @ CAL | 68 | W 5-3 | 34-34 | 3 | 7,555 | John Curtis | Rudy May | Luis Tiant | Steve Barber | | 306 | 304 | 2 |
| 1972-07-08 | @ CAL | 69 | L 3-4 | 34-35 | 3 | 9,670 | Ray Culp | Lloyd Allen | Steve Barber | Bill Lee | | 309 | 308 | 1 |
| 1972-07-09 | @ CAL | 70 | L 0-3 | 34-36 | 4 | 11,898 | Sonny Siebert | Nolan Ryan | Nolan Ryan | Sonny Siebert | | 309 | 311 | -2 |
| 1972-07-10 | @ OAK | 71 | W 4-2 | 35-36 | 3 | 29,943 | Lynn McGlothen | Ken Holtzman | Lynn McGlothen | Ken Holtzman | Luis Tiant | 313 | 313 | 0 |
| 1972-07-11 | @ OAK | 72 | W 4-0 | 36-36 | 3 | 5,539 | Marty Pattin | Joe Horlen | Marty Pattin | Joe Horlen | | 317 | 313 | 4 |
| 1972-07-12 | @ OAK | 73 | W 7-6 | 37-36 | 3 | 5,654 | John Curtis | Dave Hamilton | Bill Lee | Rollie Fingers | Don Newhauser | 324 | 319 | 5 |
| 1972-07-13 | @ MIN | 74 | L 0-10 | 37-37 | 3 | 12,969 | Ray Culp | Ray Corbin | Ray Corbin | Ray Culp | | 324 | 329 | -5 |
| 1972-07-14 | @ MIN | 75 | L 6-7 | 37-38 | 3 | 14,917 | Sonny Siebert | Jim Perry | Jim Strickland | Luis Tiant | | 330 | 336 | -6 |
| 1972-07-15 | @ MIN | 76 | L 1-7 | 37-39 | 3 | 20,709 | Lynn McGlothen | Dick Woodson | Dick Woodson | Lynn McGlothen | | 331 | 343 | -12 |
| 1972-07-16 | @ MIN | 77 | W 6-1 | 38-39 | 3 | 18,222 | Marty Pattin | Bert Blyleven | Marty Pattin | Bert Blyleven | | 337 | 344 | -7 |
| 1972-07-17 | vs CAL | 78 | W 4-1 | 39-39 | 3 | 13,793 | John Curtis | Steve Barber | John Curtis | Don Rose | | 341 | 345 | -4 |
| 1972-07-18 | vs CAL | 79 | W 4-1 | 40-39 | 3 | 0 | Sonny Siebert | Nolan Ryan | Sonny Siebert | Nolan Ryan | | 345 | 346 | -1 |
| 1972-07-19 | vs CAL | 80 | W 8-2 | 41-39 | 3 | 24,794 | Lynn McGlothen | Clyde Wright | Lynn McGlothen | Clyde Wright | | 353 | 348 | 5 |
| 1972-07-20 | vs OAK | 81 | W 2-1 | 43-39 | 3 | 0 | Marty Pattin | Ken Holtzman | Marty Pattin | Ken Holtzman | | 355 | 349 | 6 |
| 1972-07-20 | vs OAK | 82 | W 4-3 | 43-39 | 3 | 33,657 | Gary Peters | Vida Blue | Don Newhauser | Darold Knowles | | 359 | 352 | 7 |
| 1972-07-21 | vs OAK | 83 | W 5-4 | 44-39 | 3 | 27,465 | John Curtis | Dave Hamilton | Don Newhauser | Gary Waslewski | | 364 | 356 | 8 |
| 1972-07-22 | vs OAK | 84 | L 3-5 | 45-40 | 3 | 26,067 | Luis Tiant | Catfish Hunter | Darold Knowles | Gary Peters | Rollie Fingers | 367 | 361 | 6 |
| 1972-07-22 | vs OAK | 85 | W 3-0 | 45-40 | 3 | 33,279 | Sonny Siebert | Joe Horlen | Sonny Siebert | Joe Horlen | | 370 | 361 | 9 |
| 1972-07-23 | vs OAK | 86 | L 3-6 | 45-41 | 3 | 28,481 | Lynn McGlothen | Blue Moon Odom | Ken Holtzman | Lynn McGlothen | Rollie Fingers | 373 | 367 | 6 |
| 1972-07-27 | @ NYA | 87 | L 2-6 | 45-42 | 3 | 12,724 | Marty Pattin | Fritz Peterson | Fritz Peterson | Marty Pattin | Sparky Lyle | 375 | 373 | 2 |
| 1972-07-28 | @ NYA | 88 | W 6-5 | 46-43 | 3 | 0 | Gary Peters | Mel Stottlemyre | Don Newhauser | Sparky Lyle | | 381 | 378 | 3 |
| 1972-07-28 | @ NYA | 89 | L 1-3 | 46-43 | 3 | 20,129 | Sonny Siebert | Steve Kline | Steve Kline | Sonny Siebert | | 382 | 381 | 1 |
| 1972-07-29 | @ NYA | 90 | L 1-8 | 46-44 | 3 | 13,477 | John Curtis | Mike Kekich | Mike Kekich | John Curtis | | 383 | 389 | -6 |
| 1972-07-30 | @ DET | 91 | W 4-3 | 47-45 | 3 | 0 | Lynn McGlothen | Chuck Seelbach | Lynn McGlothen | Chuck Seelbach | Don Newhauser | 387 | 392 | -5 |
| 1972-07-30 | @ DET | 92 | L 2-7 | 47-45 | 3 | 44,612 | Luis Tiant | Joe Niekro | Joe Niekro | Luis Tiant | | 389 | 399 | -10 |
| 1972-07-31 | @ DET | 93 | L 2-5 | 47-46 | 4 | 41,431 | Marty Pattin | Mickey Lolich | Mickey Lolich | Marty Pattin | | 391 | 404 | -13 |
| 1972-08-01 | vs NYA | 94 | L 4-10 | 47-47 | 4 | 23,070 | Sonny Siebert | Mel Stottlemyre | Mel Stottlemyre | Sonny Siebert | Fred Beene | 395 | 414 | -19 |
| 1972-08-02 | vs NYA | 95 | L 1-5 | 48-48 | 4 | 16,491 | John Curtis | Steve Kline | Steve Kline | John Curtis | | 396 | 419 | -23 |
| 1972-08-02 | vs NYA | 96 | W 7-4 | 48-48 | 4 | 21,917 | Gary Peters | Mike Kekich | Gary Peters | Mike Kekich | Luis Tiant | 403 | 423 | -20 |
| 1972-08-03 | vs NYA | 97 | W 7-2 | 49-48 | 4 | 18,065 | Lynn McGlothen | Ron Klimkowski | Lynn McGlothen | Ron Klimkowski | | 410 | 425 | -15 |
| 1972-08-04 | vs BAL | 98 | W 2-0 | 50-48 | 4 | 31,852 | Marty Pattin | Pat Dobson | Marty Pattin | Pat Dobson | | 412 | 425 | -13 |
| 1972-08-05 | vs BAL | 99 | W 6-3 | 51-48 | 3 | 25,735 | Luis Tiant | Dave McNally | Luis Tiant | Dave McNally | | 418 | 428 | -10 |
| 1972-08-06 | vs BAL | 100 | L 2-11 | 51-49 | 4 | 28,976 | John Curtis | Jim Palmer | Jim Palmer | John Curtis | | 420 | 439 | -19 |
| 1972-08-07 | vs CLE | 101 | L 2-6 | 51-50 | 4 | 10,137 | Lynn McGlothen | Tom Hilgendorf | Phil Hennigan | Lynn McGlothen | | 422 | 445 | -23 |
| 1972-08-08 | vs CLE | 102 | W 4-1 | 52-50 | 4 | 19,651 | Marty Pattin | Dick Tidrow | Marty Pattin | Dick Tidrow | | 426 | 446 | -20 |
| 1972-08-09 | vs CLE | 103 | W 5-2 | 53-50 | 4 | 23,511 | Sonny Siebert | Gaylord Perry | Sonny Siebert | Gaylord Perry | Gary Peters | 431 | 448 | -17 |
| 1972-08-11 | @ BAL | 104 | L 1-2 | 53-51 | 4 | 17,434 | Lynn McGlothen | Mike Cuellar | Mike Cuellar | Don Newhauser | | 432 | 450 | -18 |
| 1972-08-12 | @ BAL | 105 | L 2-3 | 54-52 | 4 | 24,297 | Marty Pattin | Pat Dobson | Roric Harrison | Marty Pattin | | 434 | 453 | -19 |
| 1972-08-12 | @ BAL | 106 | W 5-3 | 54-52 | 4 | 24,297 | Luis Tiant | Doyle Alexander | Luis Tiant | Doyle Alexander | | 439 | 456 | -17 |
| 1972-08-13 | @ BAL | 107 | L 2-8 | 54-53 | 4 | 16,220 | Sonny Siebert | Dave McNally | Dave McNally | Sonny Siebert | Eddie Watt | 441 | 464 | -23 |
| 1972-08-15 | @ TEX | 108 | W 3-0 | 55-53 | 4 | 6,822 | John Curtis | Don Stanhouse | John Curtis | Don Stanhouse | | 444 | 464 | -20 |
| 1972-08-16 | @ TEX | 109 | L 8-9 | 55-54 | 4 | 8,020 | Lynn McGlothen | Rich Hand | Casey Cox | Ken Tatum | | 452 | 473 | -21 |
| 1972-08-17 | @ TEX | 110 | W 4-3 | 56-54 | 4 | 5,754 | Marty Pattin | Mike Paul | Marty Pattin | Mike Paul | Bill Lee | 456 | 476 | -20 |
| 1972-08-18 | @ CHA | 111 | L 1-8 | 56-55 | 4 | 42,001 | Sonny Siebert | Stan Bahnsen | Stan Bahnsen | Sonny Siebert | Terry Forster | 457 | 484 | -27 |
| 1972-08-19 | @ CHA | 112 | W 3-0 | 57-55 | 4 | 13,793 | Luis Tiant | Tom Bradley | Luis Tiant | Tom Bradley | | 460 | 484 | -24 |
| 1972-08-20 | @ CHA | 113 | L 7-9 | 58-56 | 4 | 0 | Lynn McGlothen | Wilbur Wood | Terry Forster | Marty Pattin | | 467 | 493 | -26 |
| 1972-08-20 | @ CHA | 114 | W 5-4 | 58-56 | 4 | 29,497 | John Curtis | Eddie Fisher | John Curtis | Eddie Fisher | Bill Lee | 472 | 497 | -25 |
| 1972-08-22 | @ KCA | 115 | W 10-7 | 59-56 | 4 | 9,058 | Marty Pattin | Mike Hedlund | Marty Pattin | Mike Hedlund | Don Newhauser | 482 | 504 | -22 |
| 1972-08-23 | @ KCA | 116 | L 0-3 | 59-57 | 4 | 9,380 | Sonny Siebert | Roger Nelson | Roger Nelson | Sonny Siebert | | 482 | 507 | -25 |
| 1972-08-25 | vs TEX | 117 | W 4-0 | 60-57 | 4 | 33,551 | Luis Tiant | Don Stanhouse | Luis Tiant | Don Stanhouse | | 486 | 507 | -21 |
| 1972-08-26 | vs TEX | 118 | W 7-6 | 61-57 | 3 | 18,107 | Lynn McGlothen | Bill Gogolewski | Don Newhauser | Casey Cox | | 493 | 513 | -20 |
| 1972-08-27 | vs TEX | 119 | W 10-3 | 62-57 | 3 | 17,755 | Marty Pattin | Rich Hand | Marty Pattin | Rich Hand | | 503 | 516 | -13 |
| 1972-08-28 | vs CHA | 120 | L 4-6 | 62-58 | 4 | 24,007 | Sonny Siebert | Dave Lemonds | Rich Gossage | Sonny Siebert | Terry Forster | 507 | 522 | -15 |
| 1972-08-29 | vs CHA | 121 | W 3-0 | 63-58 | 3 | 23,601 | Luis Tiant | Tom Bradley | Luis Tiant | Tom Bradley | | 510 | 522 | -12 |
| 1972-08-30 | vs CHA | 122 | W 4-2 | 64-58 | 3 | 26,062 | Lynn McGlothen | Wilbur Wood | Lynn McGlothen | Wilbur Wood | | 514 | 524 | -10 |
| 1972-09-01 | vs KCA | 123 | W 1-0 | 65-58 | 4 | 18,990 | Marty Pattin | Dick Drago | Marty Pattin | Dick Drago | | 515 | 524 | -9 |
| 1972-09-02 | vs KCA | 124 | W 5-3 | 66-58 | 4 | 11,495 | Sonny Siebert | Mike Hedlund | Sonny Siebert | Mike Hedlund | Bobby Bolin | 520 | 527 | -7 |
| 1972-09-04 | @ MIL | 125 | W 2-0 | 67-59 | 3 | 0 | Luis Tiant | Jim Lonborg | Luis Tiant | Jim Lonborg | | 522 | 527 | -5 |
| 1972-09-04 | @ MIL | 126 | L 2-6 | 67-59 | 3 | 12,011 | Lynn McGlothen | Ken Brett | Ken Brett | Lynn McGlothen | Frank Linzy | 524 | 533 | -9 |
| 1972-09-05 | @ MIL | 127 | W 5-3 | 68-59 | 2 | 3,877 | Marty Pattin | Skip Lockwood | Gary Peters | Skip Lockwood | | 529 | 536 | -7 |
| 1972-09-06 | vs NYA | 128 | W 2-0 | 69-59 | 2 | 18,235 | John Curtis | Mel Stottlemyre | John Curtis | Mel Stottlemyre | Bobby Bolin | 531 | 536 | -5 |
| 1972-09-07 | vs NYA | 129 | W 10-4 | 70-59 | 1 | 24,661 | Sonny Siebert | Steve Kline | Sonny Siebert | Steve Kline | | 541 | 540 | 1 |
| 1972-09-08 | vs NYA | 130 | W 4-2 | 71-59 | 1 | 28,462 | Luis Tiant | Fritz Peterson | Luis Tiant | Fritz Peterson | | 545 | 542 | 3 |
| 1972-09-09 | @ CLE | 131 | L 1-2 | 71-60 | 1 | 4,694 | Lynn McGlothen | Gaylord Perry | Gaylord Perry | Gary Peters | | 546 | 544 | 2 |
| 1972-09-10 | @ CLE | 132 | W 5-1 | 73-60 | 1 | 0 | Marty Pattin | Marcelino Lopez | Bob Veale | Ed Farmer | Bobby Bolin | 551 | 545 | 6 |
| 1972-09-10 | @ CLE | 133 | W 2-0 | 73-60 | 1 | 10,842 | John Curtis | Steve Dunning | John Curtis | Steve Dunning | | 553 | 545 | 8 |
| 1972-09-11 | @ CLE | 134 | L 5-6 | 73-61 | 1 | 2,723 | Sonny Siebert | Dick Tidrow | Ray Lamb | Bill Lee | Steve Mingori | 558 | 551 | 7 |
| 1972-09-12 | @ NYA | 135 | L 2-3 | 73-62 | 1 | 20,187 | Luis Tiant | Fritz Peterson | Fritz Peterson | Luis Tiant | Sparky Lyle | 560 | 554 | 6 |
| 1972-09-13 | @ NYA | 136 | W 7-2 | 74-62 | 1 | 15,322 | Lynn McGlothen | Rob Gardner | Lynn McGlothen | Rob Gardner | Bob Veale | 567 | 556 | 11 |
| 1972-09-15 | vs CLE | 137 | W 4-3 | 75-62 | 1 | 19,880 | Marty Pattin | Steve Dunning | Bob Veale | Milt Wilcox | | 571 | 559 | 12 |
| 1972-09-16 | vs CLE | 138 | W 10-0 | 76-62 | 1 | 17,335 | Luis Tiant | Dick Tidrow | Luis Tiant | Dick Tidrow | | 581 | 559 | 22 |
| 1972-09-17 | vs CLE | 139 | L 2-9 | 76-63 | 1 | 21,502 | John Curtis | Gaylord Perry | Gaylord Perry | John Curtis | | 583 | 568 | 15 |
| 1972-09-18 | vs BAL | 140 | L 2-5 | 76-64 | 2 | 17,803 | Lynn McGlothen | Pat Dobson | Pat Dobson | Lynn McGlothen | Doyle Alexander | 585 | 573 | 12 |
| 1972-09-20 | vs BAL | 141 | W 9-1 | 78-64 | 1 | 0 | Marty Pattin | Jim Palmer | Marty Pattin | Jim Palmer | | 594 | 574 | 20 |
| 1972-09-20 | vs BAL | 142 | W 4-0 | 78-64 | 1 | 28,777 | Luis Tiant | Mike Cuellar | Luis Tiant | Mike Cuellar | | 598 | 574 | 24 |
| 1972-09-21 | vs DET | 143 | L 3-10 | 78-65 | 1 | 20,492 | Mike Garman | Joe Coleman | Joe Coleman | Mike Garman | | 601 | 584 | 17 |
| 1972-09-22 | vs DET | 144 | W 3-2 | 79-65 | 1 | 34,632 | Lynn McGlothen | Chris Zachary | Lynn McGlothen | Chris Zachary | Bobby Bolin | 604 | 586 | 18 |
| 1972-09-23 | vs DET | 145 | L 1-7 | 79-66 | 1 | 30,407 | Sonny Siebert | Mickey Lolich | Mickey Lolich | Sonny Siebert | | 605 | 593 | 12 |
| 1972-09-24 | vs DET | 146 | W 7-2 | 80-66 | 1 | 34,182 | Luis Tiant | Woodie Fryman | Luis Tiant | Woodie Fryman | | 612 | 595 | 17 |
| 1972-09-26 | vs MIL | 147 | L 4-6 | 80-67 | 1 | 20,669 | Marty Pattin | Bill Parsons | Jerry Bell | Marty Pattin | Frank Linzy | 616 | 601 | 15 |
| 1972-09-27 | vs MIL | 148 | W 7-5 | 81-67 | 1 | 8,744 | Lynn McGlothen | Ken Brett | Bill Lee | Ken Brett | Bobby Bolin | 623 | 606 | 17 |
| 1972-09-28 | vs KCA | 149 | W 3-1 | 82-67 | 1 | 10,196 | John Curtis | Dick Drago | John Curtis | Dick Drago | | 626 | 607 | 19 |
| 1972-09-29 | @ BAL | 150 | W 4-2 | 83-67 | 1 | 10,184 | Luis Tiant | Jim Palmer | Luis Tiant | Jim Palmer | | 630 | 609 | 21 |
| 1972-09-30 | @ BAL | 151 | W 3-1 | 84-67 | 1 | 12,807 | Marty Pattin | Pat Dobson | Marty Pattin | Pat Dobson | Bob Veale | 633 | 610 | 23 |
| 1972-10-01 | @ BAL | 152 | L 1-2 | 84-68 | 1 | 9,718 | Lynn McGlothen | Mike Cuellar | Mike Cuellar | Lynn McGlothen | | 634 | 612 | 22 |
| 1972-10-02 | @ DET | 153 | L 1-4 | 84-69 | 2 | 51,518 | John Curtis | Mickey Lolich | Mickey Lolich | John Curtis | | 635 | 616 | 19 |
| 1972-10-03 | @ DET | 154 | L 1-3 | 84-70 | 2 | 50,653 | Luis Tiant | Woodie Fryman | Woodie Fryman | Luis Tiant | Chuck Seelbach | 636 | 619 | 17 |
| 1972-10-04 | @ DET | 155 | W 4-1 | 85-70 | 2 | 21,956 | Marty Pattin | Joe Coleman | Marty Pattin | Joe Coleman | | 640 | 620 | 20 |