| 1972-04-16 | @ BAL | 1 | L 1-3 | 0-1 | 6 | 13,153 | Mel Stottlemyre | Pat Dobson | Pat Dobson | Mel Stottlemyre | Doyle Alexander | 1 | 3 | -2 |
| 1972-04-17 | @ BAL | 2 | L 0-4 | 0-2 | 6 | 4,693 | Fritz Peterson | Dave McNally | Dave McNally | Fritz Peterson | | 1 | 7 | -6 |
| 1972-04-18 | vs MIL | 3 | W 2-0 | 1-2 | 6 | 11,319 | Steve Kline | Jim Slaton | Steve Kline | Jim Slaton | | 3 | 7 | -4 |
| 1972-04-19 | vs MIL | 4 | W 3-2 | 2-2 | 4 | 5,502 | Mike Kekich | Ken Brett | Mike Kekich | Ken Brett | Sparky Lyle | 6 | 9 | -3 |
| 1972-04-21 | @ BOS | 5 | L 4-5 | 2-3 | 5 | 14,895 | Mel Stottlemyre | Ray Culp | Ray Culp | Mel Stottlemyre | Bill Lee | 10 | 14 | -4 |
| 1972-04-22 | @ BOS | 6 | L 7-11 | 2-4 | 5 | 11,162 | Fritz Peterson | Sonny Siebert | Sonny Siebert | Fritz Peterson | Lew Krausse | 17 | 25 | -8 |
| 1972-04-25 | vs OAK | 7 | L 3-4 | 2-5 | 6 | 8,334 | Steve Kline | Catfish Hunter | Rollie Fingers | Lindy McDaniel | Bob Locker | 20 | 29 | -9 |
| 1972-04-26 | vs OAK | 8 | W 4-2 | 3-5 | 5 | 6,193 | Mike Kekich | Denny McLain | Mike Kekich | Denny McLain | Fred Beene | 24 | 31 | -7 |
| 1972-04-28 | vs MIN | 9 | L 1-4 | 3-6 | 5 | 9,149 | Mel Stottlemyre | Bert Blyleven | Bert Blyleven | Mel Stottlemyre | | 25 | 35 | -10 |
| 1972-04-29 | vs MIN | 10 | L 0-2 | 3-7 | 5 | 9,168 | Fritz Peterson | Jim Kaat | Jim Kaat | Fritz Peterson | Dave LaRoche | 25 | 37 | -12 |
| 1972-04-30 | vs MIN | 11 | W 5-4 | 4-8 | 5 | 0 | Steve Kline | Jim Perry | Sparky Lyle | Tom Norton | | 30 | 41 | -11 |
| 1972-04-30 | vs MIN | 12 | L 4-5 | 4-8 | 5 | 27,475 | Mike Kekich | Dick Woodson | Dick Woodson | Fred Beene | Dave LaRoche | 34 | 46 | -12 |
| 1972-05-02 | vs CAL | 13 | W 5-0 | 5-8 | 4 | 5,827 | Mel Stottlemyre | Rudy May | Mel Stottlemyre | Rudy May | | 39 | 46 | -7 |
| 1972-05-05 | @ OAK | 14 | L 1-3 | 5-9 | 4 | 6,398 | Fritz Peterson | Ken Holtzman | Ken Holtzman | Fritz Peterson | | 40 | 49 | -9 |
| 1972-05-06 | @ OAK | 15 | L 1-4 | 5-10 | 4 | 12,937 | Mike Kekich | Catfish Hunter | Catfish Hunter | Mike Kekich | Bob Locker | 41 | 53 | -12 |
| 1972-05-07 | @ OAK | 16 | L 5-7 | 5-11 | 4 | 12,347 | Steve Kline | Denny McLain | Joe Horlen | Steve Kline | Darold Knowles | 46 | 60 | -14 |
| 1972-05-08 | @ MIN | 17 | W 5-3 | 6-11 | 4 | 15,596 | Mel Stottlemyre | Bert Blyleven | Mel Stottlemyre | Bert Blyleven | Sparky Lyle | 51 | 63 | -12 |
| 1972-05-09 | @ MIN | 18 | L 2-4 | 6-12 | 5 | 6,446 | Fritz Peterson | Jim Kaat | Jim Kaat | Fritz Peterson | Wayne Granger | 53 | 67 | -14 |
| 1972-05-10 | @ MIN | 19 | L 0-2 | 6-13 | 4 | 8,014 | Mike Kekich | Jim Perry | Jim Perry | Mike Kekich | Wayne Granger | 53 | 69 | -16 |
| 1972-05-12 | @ CAL | 20 | W 6-3 | 7-13 | 5 | 12,356 | Steve Kline | Rickey Clark | Steve Kline | Rickey Clark | Sparky Lyle | 59 | 72 | -13 |
| 1972-05-13 | @ CAL | 21 | W 3-0 | 8-13 | 5 | 26,219 | Mel Stottlemyre | Rudy May | Mel Stottlemyre | Rudy May | | 62 | 72 | -10 |
| 1972-05-14 | @ CAL | 22 | L 2-6 | 8-14 | 5 | 7,659 | Fritz Peterson | Clyde Wright | Clyde Wright | Fritz Peterson | Lloyd Allen | 64 | 78 | -14 |
| 1972-05-16 | @ CLE | 23 | W 3-1 | 9-14 | 5 | 6,377 | Mike Kekich | Steve Hargan | Mike Kekich | Steve Hargan | Sparky Lyle | 67 | 79 | -12 |
| 1972-05-17 | @ CLE | 24 | L 1-2 | 9-15 | 5 | 7,722 | Steve Kline | Dick Tidrow | Dick Tidrow | Fred Beene | | 68 | 81 | -13 |
| 1972-05-19 | vs BOS | 25 | W 6-0 | 10-15 | 4 | 9,604 | Mel Stottlemyre | Marty Pattin | Mel Stottlemyre | Marty Pattin | | 74 | 81 | -7 |
| 1972-05-21 | vs BOS | 26 | W 6-3 | 12-15 | 4 | 0 | Fritz Peterson | Ray Culp | Fritz Peterson | Ray Culp | Sparky Lyle | 80 | 84 | -4 |
| 1972-05-21 | vs BOS | 27 | W 3-2 | 12-15 | 4 | 23,287 | Mike Kekich | Gary Peters | Mike Kekich | Gary Peters | Sparky Lyle | 83 | 86 | -3 |
| 1972-05-23 | vs CLE | 28 | L 0-3 | 12-16 | 4 | 10,677 | Mel Stottlemyre | Gaylord Perry | Gaylord Perry | Mel Stottlemyre | | 83 | 89 | -6 |
| 1972-05-24 | vs CLE | 29 | W 4-2 | 13-16 | 4 | 7,134 | Rich Hinton | Vince Colbert | Rich Hinton | Vince Colbert | Sparky Lyle | 87 | 91 | -4 |
| 1972-05-25 | vs CLE | 30 | W 2-0 | 14-16 | 4 | 5,519 | Fritz Peterson | Dick Tidrow | Fritz Peterson | Dick Tidrow | | 89 | 91 | -2 |
| 1972-05-26 | vs DET | 31 | L 2-8 | 14-17 | 4 | 9,579 | Mike Kekich | Tom Timmermann | Tom Timmermann | Mike Kekich | Fred Scherman | 91 | 99 | -8 |
| 1972-05-27 | vs DET | 32 | L 1-2 | 14-18 | 4 | 20,482 | Mel Stottlemyre | Joe Coleman | Joe Coleman | Mel Stottlemyre | Fred Scherman | 92 | 101 | -9 |
| 1972-05-28 | vs DET | 33 | L 4-5 | 14-19 | 5 | 13,433 | Rich Hinton | Les Cain | Chuck Seelbach | Fred Beene | | 96 | 106 | -10 |
| 1972-05-29 | vs DET | 34 | W 5-1 | 16-19 | 4 | 0 | Steve Kline | Mickey Lolich | Steve Kline | Mickey Lolich | Sparky Lyle | 101 | 107 | -6 |
| 1972-05-29 | vs DET | 35 | W 4-2 | 16-19 | 4 | 23,013 | Fritz Peterson | Joe Niekro | Fritz Peterson | Ron Perranoski | Sparky Lyle | 105 | 109 | -4 |
| 1972-05-30 | @ MIL | 36 | L 1-3 | 16-20 | 4 | 4,185 | Mike Kekich | Skip Lockwood | Skip Lockwood | Mike Kekich | | 106 | 112 | -6 |
| 1972-05-31 | @ MIL | 37 | W 5-4 | 17-20 | 4 | 6,211 | Mel Stottlemyre | Ken Brett | Mel Stottlemyre | Ken Brett | Sparky Lyle | 111 | 116 | -5 |
| 1972-06-01 | @ MIL | 38 | L 8-9 | 17-21 | 5 | 8,241 | Rich Hinton | Jim Slaton | Ken Sanders | Jim Roland | | 119 | 125 | -6 |
| 1972-06-02 | @ CHA | 39 | L 1-6 | 17-22 | 5 | 27,634 | Fritz Peterson | Wilbur Wood | Wilbur Wood | Fritz Peterson | | 120 | 131 | -11 |
| 1972-06-03 | @ CHA | 40 | W 18-10 | 18-22 | 4 | 35,309 | Fred Beene | Stan Bahnsen | Sparky Lyle | Bart Johnson | | 138 | 141 | -3 |
| 1972-06-04 | @ CHA | 41 | L 1-6 | 18-24 | 5 | 0 | Mel Stottlemyre | Tom Bradley | Tom Bradley | Mel Stottlemyre | | 139 | 147 | -8 |
| 1972-06-04 | @ CHA | 42 | L 4-5 | 18-24 | 5 | 51,904 | Mike Kekich | Dave Lemonds | Cy Acosta | Sparky Lyle | | 143 | 152 | -9 |
| 1972-06-06 | @ TEX | 43 | L 3-6 | 18-25 | 5 | 12,865 | Fritz Peterson | Dick Bosman | Dick Bosman | Fritz Peterson | Paul Lindblad | 146 | 158 | -12 |
| 1972-06-07 | @ TEX | 44 | W 7-5 | 19-25 | 5 | 12,220 | Steve Kline | Jim Shellenback | Steve Kline | Jim Shellenback | Sparky Lyle | 153 | 163 | -10 |
| 1972-06-08 | @ TEX | 45 | L 2-6 | 19-26 | 5 | 11,897 | Mel Stottlemyre | Pete Broberg | Pete Broberg | Mel Stottlemyre | Paul Lindblad | 155 | 169 | -14 |
| 1972-06-09 | @ KCA | 46 | L 0-1 | 19-27 | 5 | 9,772 | Mike Kekich | Jim Rooker | Jim Rooker | Mike Kekich | | 155 | 170 | -15 |
| 1972-06-10 | @ KCA | 47 | W 8-4 | 20-27 | 5 | 11,282 | Fritz Peterson | Tom Murphy | Fritz Peterson | Tom Murphy | | 163 | 174 | -11 |
| 1972-06-11 | @ KCA | 48 | L 0-1 | 20-28 | 5 | 14,417 | Steve Kline | Dick Drago | Dick Drago | Steve Kline | | 163 | 175 | -12 |
| 1972-06-13 | vs CHA | 49 | L 0-2 | 20-29 | 5 | 9,066 | Mel Stottlemyre | Wilbur Wood | Wilbur Wood | Mel Stottlemyre | | 163 | 177 | -14 |
| 1972-06-14 | vs CHA | 50 | W 3-0 | 21-29 | 5 | 6,757 | Mike Kekich | Tom Bradley | Mike Kekich | Tom Bradley | Sparky Lyle | 166 | 177 | -11 |
| 1972-06-15 | vs CHA | 51 | W 8-1 | 22-29 | 5 | 9,050 | Fritz Peterson | Stan Bahnsen | Fritz Peterson | Stan Bahnsen | | 174 | 178 | -4 |
| 1972-06-17 | vs TEX | 52 | W 2-0 | 24-29 | 4 | 0 | Steve Kline | Dick Bosman | Steve Kline | Dick Bosman | | 176 | 178 | -2 |
| 1972-06-17 | vs TEX | 53 | W 3-2 | 24-29 | 4 | 10,462 | Mel Stottlemyre | Mike Paul | Mel Stottlemyre | Jim Panther | Sparky Lyle | 179 | 180 | -1 |
| 1972-06-20 | vs KCA | 54 | W 4-2 | 25-29 | 3 | 7,806 | Mike Kekich | Dick Drago | Mike Kekich | Dick Drago | Sparky Lyle | 183 | 182 | 1 |
| 1972-06-23 | @ CLE | 55 | W 4-1 | 26-29 | 3 | 5,882 | Fritz Peterson | Milt Wilcox | Fritz Peterson | Milt Wilcox | | 187 | 183 | 4 |
| 1972-06-25 | @ CLE | 56 | L 3-4 | 26-31 | 4 | 0 | Mel Stottlemyre | Gaylord Perry | Gaylord Perry | Mel Stottlemyre | Ed Farmer | 190 | 187 | 3 |
| 1972-06-25 | @ CLE | 57 | L 1-5 | 26-31 | 4 | 23,196 | Steve Kline | Mike Kilkenny | Mike Kilkenny | Steve Kline | | 191 | 192 | -1 |
| 1972-06-26 | @ DET | 58 | L 3-4 | 26-32 | 4 | 30,961 | Mike Kekich | Bill Slayback | Bill Slayback | Mike Kekich | Chuck Seelbach | 194 | 196 | -2 |
| 1972-06-27 | @ DET | 59 | L 2-5 | 26-33 | 5 | 29,449 | Wade Blasingame | Mickey Lolich | Mickey Lolich | Wade Blasingame | | 196 | 201 | -5 |
| 1972-06-28 | vs BAL | 60 | L 0-4 | 26-34 | 5 | 15,655 | Fritz Peterson | Mike Cuellar | Mike Cuellar | Fritz Peterson | | 196 | 205 | -9 |
| 1972-06-29 | vs BAL | 61 | W 4-3 | 27-34 | 4 | 8,438 | Mel Stottlemyre | Jim Palmer | Mel Stottlemyre | Jim Palmer | Sparky Lyle | 200 | 208 | -8 |
| 1972-06-30 | vs CLE | 62 | W 1-0 | 28-34 | 3 | 9,567 | Steve Kline | Gaylord Perry | Steve Kline | Gaylord Perry | | 201 | 208 | -7 |
| 1972-07-01 | vs CLE | 63 | W 5-1 | 29-34 | 3 | 9,406 | Mike Kekich | Mike Kilkenny | Mike Kekich | Mike Kilkenny | | 206 | 209 | -3 |
| 1972-07-02 | vs CLE | 64 | W 6-1 | 31-34 | 3 | 0 | Fritz Peterson | Ray Lamb | Fritz Peterson | Ray Lamb | | 212 | 210 | 2 |
| 1972-07-02 | vs CLE | 65 | W 5-2 | 31-34 | 3 | 20,140 | Rob Gardner | Milt Wilcox | Rob Gardner | Milt Wilcox | Sparky Lyle | 217 | 212 | 5 |
| 1972-07-04 | @ OAK | 66 | L 2-4 | 31-35 | 4 | 37,461 | Mel Stottlemyre | Blue Moon Odom | Blue Moon Odom | Mel Stottlemyre | Darold Knowles | 219 | 216 | 3 |
| 1972-07-05 | @ OAK | 67 | W 4-1 | 32-35 | 4 | 5,022 | Steve Kline | Ken Holtzman | Steve Kline | Ken Holtzman | | 223 | 217 | 6 |
| 1972-07-06 | @ OAK | 68 | W 6-2 | 33-35 | 4 | 4,976 | Mike Kekich | Dave Hamilton | Mike Kekich | Dave Hamilton | Sparky Lyle | 229 | 219 | 10 |
| 1972-07-07 | @ MIN | 69 | L 2-5 | 33-36 | 4 | 19,514 | Fritz Peterson | Dick Woodson | Wayne Granger | Fritz Peterson | | 231 | 224 | 7 |
| 1972-07-08 | @ MIN | 70 | W 1-0 | 34-36 | 4 | 14,866 | Mel Stottlemyre | Bert Blyleven | Mel Stottlemyre | Wayne Granger | Sparky Lyle | 232 | 224 | 8 |
| 1972-07-09 | @ MIN | 71 | W 9-6 | 35-36 | 3 | 19,613 | Steve Kline | Ray Corbin | Steve Kline | Ray Corbin | Sparky Lyle | 241 | 230 | 11 |
| 1972-07-10 | @ CAL | 72 | L 3-4 | 35-37 | 4 | 6,658 | Mike Kekich | Clyde Wright | Clyde Wright | Mike Kekich | | 244 | 234 | 10 |
| 1972-07-11 | @ CAL | 73 | W 7-3 | 36-37 | 4 | 8,513 | Fritz Peterson | Rudy May | Fritz Peterson | Rudy May | | 251 | 237 | 14 |
| 1972-07-12 | @ CAL | 74 | W 5-0 | 37-37 | 4 | 10,148 | Mel Stottlemyre | Lloyd Allen | Mel Stottlemyre | Lloyd Allen | | 256 | 237 | 19 |
| 1972-07-14 | vs OAK | 75 | L 3-9 | 37-39 | 4 | 0 | Steve Kline | Catfish Hunter | Catfish Hunter | Steve Kline | | 259 | 246 | 13 |
| 1972-07-14 | vs OAK | 76 | L 0-1 | 37-39 | 4 | 25,798 | Mike Kekich | Blue Moon Odom | Blue Moon Odom | Mike Kekich | Darold Knowles | 259 | 247 | 12 |
| 1972-07-15 | vs OAK | 77 | L 2-6 | 37-40 | 4 | 10,400 | Fritz Peterson | Ken Holtzman | Ken Holtzman | Fritz Peterson | Rollie Fingers | 261 | 253 | 8 |
| 1972-07-16 | vs OAK | 78 | L 2-5 | 37-41 | 4 | 21,006 | Mel Stottlemyre | Dave Hamilton | Dave Hamilton | Mel Stottlemyre | Bob Locker | 263 | 258 | 5 |
| 1972-07-18 | vs MIN | 79 | W 6-0 | 38-41 | 4 | 10,105 | Steve Kline | Ray Corbin | Steve Kline | Ray Corbin | | 269 | 258 | 11 |
| 1972-07-19 | vs MIN | 80 | W 13-3 | 39-41 | 4 | 19,029 | Mike Kekich | Jim Perry | Mike Kekich | Jim Perry | Fred Beene | 282 | 261 | 21 |
| 1972-07-21 | vs CAL | 81 | W 6-0 | 41-41 | 4 | 0 | Fritz Peterson | Lloyd Allen | Fritz Peterson | Lloyd Allen | | 288 | 261 | 27 |
| 1972-07-21 | vs CAL | 82 | W 3-0 | 41-41 | 4 | 10,679 | Mel Stottlemyre | Rudy May | Mel Stottlemyre | Rudy May | | 291 | 261 | 30 |
| 1972-07-22 | vs CAL | 83 | L 0-1 | 42-42 | 4 | 0 | Steve Kline | Steve Barber | Steve Barber | Sparky Lyle | Eddie Fisher | 291 | 262 | 29 |
| 1972-07-22 | vs CAL | 84 | W 7-1 | 42-42 | 4 | 35,164 | Rob Gardner | Nolan Ryan | Rob Gardner | Nolan Ryan | | 298 | 263 | 35 |
| 1972-07-23 | vs CAL | 85 | L 3-6 | 42-43 | 4 | 10,756 | Mike Kekich | Clyde Wright | Clyde Wright | Mike Kekich | Eddie Fisher | 301 | 269 | 32 |
| 1972-07-27 | vs BOS | 86 | W 6-2 | 43-43 | 4 | 12,724 | Fritz Peterson | Marty Pattin | Fritz Peterson | Marty Pattin | Sparky Lyle | 307 | 271 | 36 |
| 1972-07-28 | vs BOS | 87 | L 5-6 | 44-44 | 4 | 0 | Mel Stottlemyre | Gary Peters | Don Newhauser | Sparky Lyle | | 312 | 277 | 35 |
| 1972-07-28 | vs BOS | 88 | W 3-1 | 44-44 | 4 | 20,129 | Steve Kline | Sonny Siebert | Steve Kline | Sonny Siebert | | 315 | 278 | 37 |
| 1972-07-29 | vs BOS | 89 | W 8-1 | 45-44 | 4 | 13,477 | Mike Kekich | John Curtis | Mike Kekich | John Curtis | | 323 | 279 | 44 |
| 1972-07-30 | @ BAL | 90 | L 0-5 | 45-45 | 4 | 15,117 | Ron Klimkowski | Mike Cuellar | Mike Cuellar | Ron Klimkowski | | 323 | 284 | 39 |
| 1972-07-31 | @ BAL | 91 | W 5-2 | 47-45 | 3 | 0 | Fritz Peterson | Pat Dobson | Fritz Peterson | Pat Dobson | Sparky Lyle | 328 | 286 | 42 |
| 1972-07-31 | @ BAL | 92 | W 2-1 | 47-45 | 3 | 21,966 | Rob Gardner | Doyle Alexander | Rob Gardner | Doyle Alexander | Sparky Lyle | 330 | 287 | 43 |
| 1972-08-01 | @ BOS | 93 | W 10-4 | 48-45 | 3 | 23,070 | Mel Stottlemyre | Sonny Siebert | Mel Stottlemyre | Sonny Siebert | Fred Beene | 340 | 291 | 49 |
| 1972-08-02 | @ BOS | 94 | W 5-1 | 49-46 | 3 | 16,491 | Steve Kline | John Curtis | Steve Kline | John Curtis | | 345 | 292 | 53 |
| 1972-08-02 | @ BOS | 95 | L 4-7 | 49-46 | 3 | 21,917 | Mike Kekich | Gary Peters | Gary Peters | Mike Kekich | Luis Tiant | 349 | 299 | 50 |
| 1972-08-03 | @ BOS | 96 | L 2-7 | 49-47 | 3 | 18,065 | Ron Klimkowski | Lynn McGlothen | Lynn McGlothen | Ron Klimkowski | | 351 | 306 | 45 |
| 1972-08-04 | @ MIL | 97 | W 9-4 | 50-47 | 3 | 15,934 | Fritz Peterson | Earl Stephenson | Fritz Peterson | Earl Stephenson | Sparky Lyle | 360 | 310 | 50 |
| 1972-08-05 | @ MIL | 98 | L 0-4 | 50-48 | 4 | 8,653 | Mel Stottlemyre | Bill Parsons | Bill Parsons | Mel Stottlemyre | | 360 | 314 | 46 |
| 1972-08-06 | @ MIL | 99 | W 3-0 | 52-48 | 3 | 0 | Steve Kline | Gary Ryerson | Steve Kline | Gary Ryerson | Sparky Lyle | 363 | 314 | 49 |
| 1972-08-06 | @ MIL | 100 | W 6-4 | 52-48 | 3 | 10,616 | Mike Kekich | Skip Lockwood | Sparky Lyle | Ken Sanders | | 369 | 318 | 51 |
| 1972-08-08 | vs DET | 101 | W 4-2 | 53-48 | 3 | 22,463 | Fritz Peterson | Mickey Lolich | Sparky Lyle | Mickey Lolich | | 373 | 320 | 53 |
| 1972-08-09 | vs DET | 102 | L 0-6 | 54-49 | 3 | 0 | Mel Stottlemyre | Woodie Fryman | Woodie Fryman | Mel Stottlemyre | | 373 | 326 | 47 |
| 1972-08-09 | vs DET | 103 | W 2-1 | 54-49 | 3 | 32,610 | Rob Gardner | Tom Timmermann | Rob Gardner | Tom Timmermann | Sparky Lyle | 375 | 327 | 48 |
| 1972-08-10 | vs DET | 104 | W 1-0 | 55-49 | 3 | 40,145 | Steve Kline | Joe Coleman | Steve Kline | Joe Coleman | Sparky Lyle | 376 | 327 | 49 |
| 1972-08-11 | vs MIL | 105 | L 2-4 | 55-50 | 3 | 13,883 | Mike Kekich | Skip Lockwood | Skip Lockwood | Mike Kekich | Frank Linzy | 378 | 331 | 47 |
| 1972-08-12 | vs MIL | 106 | W 10-6 | 56-50 | 3 | 12,734 | Fritz Peterson | Jim Lonborg | Fritz Peterson | Jim Lonborg | Sparky Lyle | 388 | 337 | 51 |
| 1972-08-13 | vs MIL | 107 | W 5-3 | 58-50 | 2 | 0 | Mel Stottlemyre | Ken Brett | Mel Stottlemyre | Ken Brett | Sparky Lyle | 393 | 340 | 53 |
| 1972-08-13 | vs MIL | 108 | W 5-4 | 58-50 | 2 | 56,238 | Rob Gardner | Jim Colborn | Fred Beene | Jim Colborn | Ron Klimkowski | 398 | 344 | 54 |
| 1972-08-14 | @ KCA | 109 | L 0-3 | 58-51 | 3 | 9,377 | Steve Kline | Bruce Dal Canton | Bruce Dal Canton | Steve Kline | Norm Angelini | 398 | 347 | 51 |
| 1972-08-15 | @ KCA | 110 | L 6-7 | 58-52 | 3 | 10,721 | Mike Kekich | Mike Hedlund | Tom Burgmeier | Rob Gardner | | 404 | 354 | 50 |
| 1972-08-16 | @ KCA | 111 | L 2-3 | 58-53 | 3 | 11,579 | Fritz Peterson | Roger Nelson | Roger Nelson | Fritz Peterson | | 406 | 357 | 49 |
| 1972-08-18 | @ TEX | 112 | L 2-11 | 58-54 | 3 | 16,200 | Mel Stottlemyre | Dick Bosman | Dick Bosman | Mel Stottlemyre | Bill Gogolewski | 408 | 368 | 40 |
| 1972-08-19 | @ TEX | 113 | W 6-2 | 59-54 | 3 | 19,076 | Steve Kline | Pete Broberg | Steve Kline | Pete Broberg | | 414 | 370 | 44 |
| 1972-08-20 | @ TEX | 114 | W 2-0 | 60-54 | 3 | 12,259 | Rob Gardner | Don Stanhouse | Sparky Lyle | Horacio Pina | | 416 | 370 | 46 |
| 1972-08-22 | @ CHA | 115 | L 4-5 | 60-55 | 3 | 34,519 | Fritz Peterson | Stan Bahnsen | Rich Gossage | Fritz Peterson | Terry Forster | 420 | 375 | 45 |
| 1972-08-23 | @ CHA | 116 | L 2-5 | 60-56 | 3 | 24,678 | Mel Stottlemyre | Wilbur Wood | Wilbur Wood | Mel Stottlemyre | | 422 | 380 | 42 |
| 1972-08-25 | vs KCA | 117 | W 4-1 | 61-57 | 3 | 0 | Steve Kline | Paul Splittorff | Sparky Lyle | Al Fitzmorris | | 426 | 381 | 45 |
| 1972-08-25 | vs KCA | 118 | L 1-5 | 61-57 | 3 | 15,466 | Mike Kekich | Mike Jackson | Mike Jackson | Mike Kekich | Ted Abernathy | 427 | 386 | 41 |
| 1972-08-26 | vs KCA | 119 | L 3-6 | 61-58 | 4 | 10,670 | Rob Gardner | Dick Drago | Dick Drago | Rob Gardner | Norm Angelini | 430 | 392 | 38 |
| 1972-08-27 | vs KCA | 120 | W 7-6 | 63-58 | 4 | 0 | Mel Stottlemyre | Bruce Dal Canton | Sparky Lyle | Norm Angelini | | 437 | 398 | 39 |
| 1972-08-27 | vs KCA | 121 | W 9-8 | 63-58 | 4 | 25,801 | Fritz Peterson | Mike Hedlund | Lindy McDaniel | Bruce Dal Canton | | 446 | 406 | 40 |
| 1972-08-29 | vs TEX | 122 | W 7-6 | 64-59 | 4 | 0 | Steve Kline | Mike Paul | Sparky Lyle | Horacio Pina | | 453 | 412 | 41 |
| 1972-08-29 | vs TEX | 123 | L 4-7 | 64-59 | 4 | 15,987 | Mike Kekich | Dick Bosman | Dick Bosman | Ron Klimkowski | Paul Lindblad | 457 | 419 | 38 |
| 1972-08-30 | vs TEX | 124 | W 3-1 | 65-59 | 4 | 10,069 | Rob Gardner | Jim Panther | Rob Gardner | Jim Panther | Sparky Lyle | 460 | 420 | 40 |
| 1972-08-31 | vs TEX | 125 | W 7-0 | 66-59 | 3 | 10,116 | Fritz Peterson | Rich Hand | Fritz Peterson | Rich Hand | | 467 | 420 | 47 |
| 1972-09-01 | vs CHA | 126 | W 4-0 | 67-59 | 3 | 18,145 | Mel Stottlemyre | Dave Lemonds | Mel Stottlemyre | Dave Lemonds | | 471 | 420 | 51 |
| 1972-09-02 | vs CHA | 127 | W 2-1 | 68-59 | 3 | 10,768 | Steve Kline | Tom Bradley | Steve Kline | Tom Bradley | | 473 | 421 | 52 |
| 1972-09-03 | vs CHA | 128 | L 0-5 | 68-60 | 4 | 23,974 | Casey Cox | Wilbur Wood | Wilbur Wood | Casey Cox | | 473 | 426 | 47 |
| 1972-09-04 | @ BAL | 129 | L 3-4 | 69-61 | 4 | 0 | Fritz Peterson | Doyle Alexander | Roric Harrison | Sparky Lyle | | 476 | 430 | 46 |
| 1972-09-04 | @ BAL | 130 | W 5-2 | 69-61 | 4 | 18,332 | Rob Gardner | Pat Dobson | Rob Gardner | Pat Dobson | Sparky Lyle | 481 | 432 | 49 |
| 1972-09-05 | @ BAL | 131 | W 7-6 | 70-61 | 3 | 8,539 | Doc Medich | Dave McNally | Lindy McDaniel | Dave McNally | Sparky Lyle | 488 | 438 | 50 |
| 1972-09-06 | @ BOS | 132 | L 0-2 | 70-62 | 3 | 18,235 | Mel Stottlemyre | John Curtis | John Curtis | Mel Stottlemyre | Bobby Bolin | 488 | 440 | 48 |
| 1972-09-07 | @ BOS | 133 | L 4-10 | 70-63 | 4 | 24,661 | Steve Kline | Sonny Siebert | Sonny Siebert | Steve Kline | | 492 | 450 | 42 |
| 1972-09-08 | @ BOS | 134 | L 2-4 | 70-64 | 4 | 28,462 | Fritz Peterson | Luis Tiant | Luis Tiant | Fritz Peterson | | 494 | 454 | 40 |
| 1972-09-09 | @ DET | 135 | W 3-1 | 71-64 | 4 | 41,624 | Rob Gardner | Joe Coleman | Rob Gardner | Joe Coleman | Sparky Lyle | 497 | 455 | 42 |
| 1972-09-10 | @ DET | 136 | W 5-0 | 72-64 | 4 | 31,657 | Mel Stottlemyre | Mickey Lolich | Mel Stottlemyre | Mickey Lolich | | 502 | 455 | 47 |
| 1972-09-11 | @ DET | 137 | W 4-2 | 73-64 | 3 | 15,442 | Steve Kline | Fred Scherman | Steve Kline | Fred Scherman | | 506 | 457 | 49 |
| 1972-09-12 | vs BOS | 138 | W 3-2 | 74-64 | 3 | 20,187 | Fritz Peterson | Luis Tiant | Fritz Peterson | Luis Tiant | Sparky Lyle | 509 | 459 | 50 |
| 1972-09-13 | vs BOS | 139 | L 2-7 | 74-65 | 4 | 15,322 | Rob Gardner | Lynn McGlothen | Lynn McGlothen | Rob Gardner | Bob Veale | 511 | 466 | 45 |
| 1972-09-15 | vs BAL | 140 | L 1-3 | 74-66 | 4 | 28,681 | Mel Stottlemyre | Jim Palmer | Jim Palmer | Mel Stottlemyre | Grant Jackson | 512 | 469 | 43 |
| 1972-09-16 | vs BAL | 141 | L 3-7 | 74-67 | 4 | 25,102 | Steve Kline | Mike Cuellar | Mike Cuellar | Steve Kline | | 515 | 476 | 39 |
| 1972-09-17 | vs BAL | 142 | W 2-1 | 75-67 | 4 | 30,072 | Fritz Peterson | Dave McNally | Fritz Peterson | Dave McNally | Sparky Lyle | 517 | 477 | 40 |
| 1972-09-19 | @ MIL | 143 | L 2-7 | 75-68 | 4 | 4,122 | Rob Gardner | Bill Parsons | Bill Parsons | Rob Gardner | | 519 | 484 | 35 |
| 1972-09-21 | @ MIL | 144 | L 4-6 | 75-69 | 4 | 4,185 | Mike Kekich | Jerry Bell | Jerry Bell | Mike Kekich | Ken Sanders | 523 | 490 | 33 |
| 1972-09-22 | @ CLE | 145 | L 1-4 | 75-70 | 4 | 3,436 | Steve Kline | Gaylord Perry | Gaylord Perry | Steve Kline | | 524 | 494 | 30 |
| 1972-09-23 | @ CLE | 146 | W 5-2 | 76-70 | 4 | 4,500 | Fritz Peterson | Steve Dunning | Fritz Peterson | Steve Dunning | | 529 | 496 | 33 |
| 1972-09-24 | @ CLE | 147 | W 5-4 | 78-70 | 4 | 0 | Mel Stottlemyre | Ray Lamb | Lindy McDaniel | Steve Mingori | | 534 | 500 | 34 |
| 1972-09-24 | @ CLE | 148 | W 8-3 | 78-70 | 4 | 6,979 | Rob Gardner | Milt Wilcox | Rob Gardner | Milt Wilcox | Sparky Lyle | 542 | 503 | 39 |
| 1972-09-27 | @ DET | 149 | L 5-6 | 78-71 | 4 | 21,850 | Steve Kline | Joe Coleman | Chuck Seelbach | Sparky Lyle | | 547 | 509 | 38 |
| 1972-09-28 | @ DET | 150 | W 3-2 | 79-71 | 3 | 21,185 | Mel Stottlemyre | Mickey Lolich | Sparky Lyle | Mickey Lolich | | 550 | 511 | 39 |
| 1972-10-01 | vs CLE | 151 | L 1-2 | 79-73 | 4 | 0 | Fritz Peterson | Gaylord Perry | Gaylord Perry | Fritz Peterson | | 551 | 513 | 38 |
| 1972-10-01 | vs CLE | 152 | L 3-4 | 79-73 | 4 | 13,033 | Rob Gardner | Steve Dunning | Steve Dunning | Rob Gardner | Ed Farmer | 554 | 517 | 37 |
| 1972-10-02 | vs MIL | 153 | L 1-6 | 79-74 | 4 | 3,927 | Steve Kline | Ken Brett | Ken Brett | Steve Kline | | 555 | 523 | 32 |
| 1972-10-03 | vs MIL | 154 | L 2-3 | 79-75 | 4 | 5,803 | Mel Stottlemyre | Skip Lockwood | Skip Lockwood | Mel Stottlemyre | Chuck Taylor | 557 | 526 | 31 |
| 1972-10-04 | vs MIL | 155 | L 0-1 | 79-76 | 4 | 5,210 | Larry Gowell | Jim Lonborg | Jim Lonborg | Larry Gowell | | 557 | 527 | 30 |