| 1971-04-06 | vs SLN | 1 | W 2-1 | 1-0 | 1 | 39,079 | Fergie Jenkins | Bob Gibson | Fergie Jenkins | Bob Gibson | | 2 | 1 | 1 |
| 1971-04-07 | vs SLN | 2 | L 3-14 | 1-1 | 3 | 23,287 | Bill Hands | Steve Carlton | Steve Carlton | Bill Hands | | 5 | 15 | -10 |
| 1971-04-08 | @ HOU | 3 | L 3-7 | 1-2 | 5 | 11,375 | Ken Holtzman | Jack Billingham | Jack Billingham | Ken Holtzman | | 8 | 22 | -14 |
| 1971-04-09 | @ HOU | 4 | W 6-0 | 2-2 | 2 | 17,359 | Milt Pappas | Tom Griffin | Milt Pappas | Tom Griffin | | 14 | 22 | -8 |
| 1971-04-10 | @ HOU | 5 | L 1-2 | 2-3 | 3 | 22,341 | Fergie Jenkins | Larry Dierker | George Culver | Fergie Jenkins | | 15 | 24 | -9 |
| 1971-04-11 | @ HOU | 6 | L 4-7 | 2-4 | 5 | 12,978 | Bill Hands | Don Wilson | Don Wilson | Bill Hands | | 19 | 31 | -12 |
| 1971-04-12 | @ LAN | 7 | L 3-4 | 2-5 | 5 | 15,407 | Ken Holtzman | Sandy Vance | Sandy Vance | Ken Holtzman | Jim Brewer | 22 | 35 | -13 |
| 1971-04-13 | @ LAN | 8 | W 3-2 | 3-5 | 5 | 15,458 | Milt Pappas | Bill Singer | Milt Pappas | Bill Singer | | 25 | 37 | -12 |
| 1971-04-15 | @ SDN | 9 | W 4-3 | 4-5 | 3 | 4,515 | Bill Hands | Steve Arlin | Bill Hands | Steve Arlin | | 29 | 40 | -11 |
| 1971-04-16 | @ SFN | 10 | L 0-9 | 4-6 | 4 | 8,133 | Fergie Jenkins | Juan Marichal | Juan Marichal | Fergie Jenkins | | 29 | 49 | -20 |
| 1971-04-17 | @ SFN | 11 | L 3-5 | 4-7 | 5 | 32,896 | Ken Holtzman | Gaylord Perry | Gaylord Perry | Ken Holtzman | | 32 | 54 | -22 |
| 1971-04-18 | @ SFN | 12 | L 1-5 | 4-9 | 5 | 0 | Milt Pappas | Steve Stone | John Cumberland | Milt Pappas | | 33 | 59 | -26 |
| 1971-04-18 | @ SFN | 13 | L 1-8 | 4-9 | 5 | 27,714 | Bill Bonham | Rich Robertson | Rich Robertson | Bill Bonham | | 34 | 67 | -33 |
| 1971-04-20 | vs HOU | 14 | W 3-1 | 5-9 | 6 | 6,199 | Fergie Jenkins | Tom Griffin | Fergie Jenkins | Tom Griffin | | 37 | 68 | -31 |
| 1971-04-22 | vs HOU | 15 | L 1-6 | 5-10 | 5 | 4,100 | Bill Hands | Larry Dierker | Larry Dierker | Bill Hands | | 38 | 74 | -36 |
| 1971-04-23 | vs NYN | 16 | L 6-7 | 5-11 | 6 | 8,418 | Ken Holtzman | Jerry Koosman | Nolan Ryan | Ron Tompkins | | 44 | 81 | -37 |
| 1971-04-24 | vs NYN | 17 | W 7-5 | 6-11 | 6 | 23,749 | Milt Pappas | Gary Gentry | Milt Pappas | Gary Gentry | Earl Stephenson | 51 | 86 | -35 |
| 1971-04-25 | vs NYN | 18 | W 9-3 | 7-11 | 5 | 27,223 | Fergie Jenkins | Jim McAndrew | Fergie Jenkins | Jim McAndrew | | 60 | 89 | -29 |
| 1971-04-28 | vs MON | 19 | W 3-2 | 8-11 | 5 | 4,374 | Bill Hands | Carl Morton | Bill Hands | Carl Morton | | 63 | 91 | -28 |
| 1971-04-29 | vs MON | 20 | L 6-7 | 8-12 | 5 | 7,889 | Ken Holtzman | Ernie McAnally | Claude Raymond | Phil Regan | Mike Marshall | 69 | 98 | -29 |
| 1971-04-30 | vs PHI | 21 | L 0-1 | 8-13 | 5 | 9,110 | Milt Pappas | Chris Short | Chris Short | Milt Pappas | | 69 | 99 | -30 |
| 1971-05-01 | vs PHI | 22 | W 7-4 | 9-13 | 5 | 16,618 | Fergie Jenkins | Rick Wise | Fergie Jenkins | Rick Wise | | 76 | 103 | -27 |
| 1971-05-02 | vs PHI | 23 | W 7-1 | 10-13 | 5 | 9,585 | Bill Hands | Jim Bunning | Bill Hands | Jim Bunning | | 83 | 104 | -21 |
| 1971-05-03 | @ NYN | 24 | L 2-3 | 10-14 | 5 | 16,174 | Ken Holtzman | Gary Gentry | Tug McGraw | Ken Holtzman | | 85 | 107 | -22 |
| 1971-05-04 | @ NYN | 25 | L 1-2 | 10-15 | 5 | 17,963 | Milt Pappas | Nolan Ryan | Nolan Ryan | Milt Pappas | Danny Frisella | 86 | 109 | -23 |
| 1971-05-05 | @ NYN | 26 | W 5-4 | 11-15 | 5 | 21,437 | Fergie Jenkins | Jim McAndrew | Fergie Jenkins | Charlie Williams | | 91 | 113 | -22 |
| 1971-05-07 | @ MON | 27 | L 1-3 | 11-16 | 5 | 17,723 | Bill Hands | Carl Morton | Carl Morton | Bill Hands | | 92 | 116 | -24 |
| 1971-05-08 | @ MON | 28 | W 3-0 | 12-16 | 5 | 20,699 | Ken Holtzman | Ernie McAnally | Ken Holtzman | Ernie McAnally | | 95 | 116 | -21 |
| 1971-05-09 | @ MON | 29 | L 3-7 | 12-17 | 5 | 16,872 | Milt Pappas | Bill Stoneman | Bill Stoneman | Milt Pappas | | 98 | 123 | -25 |
| 1971-05-10 | @ PHI | 30 | W 3-0 | 13-17 | 5 | 8,606 | Fergie Jenkins | Chris Short | Fergie Jenkins | Chris Short | | 101 | 123 | -22 |
| 1971-05-11 | @ PHI | 31 | W 6-2 | 14-17 | 5 | 9,873 | Bill Hands | Rick Wise | Bill Hands | Rick Wise | | 107 | 125 | -18 |
| 1971-05-12 | @ PHI | 32 | W 9-4 | 15-17 | 5 | 8,518 | Ken Holtzman | Jim Bunning | Ken Holtzman | Jim Bunning | | 116 | 129 | -13 |
| 1971-05-14 | vs SDN | 33 | W 3-2 | 16-17 | 4 | 7,060 | Milt Pappas | Steve Arlin | Milt Pappas | Steve Arlin | | 119 | 131 | -12 |
| 1971-05-15 | vs SDN | 34 | W 6-4 | 17-17 | 4 | 23,845 | Fergie Jenkins | Tom Phoebus | Fergie Jenkins | Dick Kelley | | 125 | 135 | -10 |
| 1971-05-16 | vs SDN | 35 | W 9-8 | 19-17 | 4 | 0 | Bill Hands | Danny Coombs | Earl Stephenson | Al Santorini | | 134 | 143 | -9 |
| 1971-05-16 | vs SDN | 36 | W 6-4 | 19-17 | 4 | 37,972 | Ken Holtzman | Clay Kirby | Ken Holtzman | Clay Kirby | Phil Regan | 140 | 147 | -7 |
| 1971-05-18 | vs SFN | 37 | L 3-7 | 19-18 | 4 | 12,600 | Milt Pappas | Ron Bryant | Ron Bryant | Milt Pappas | Jerry Johnson | 143 | 154 | -11 |
| 1971-05-19 | vs SFN | 38 | W 9-5 | 20-18 | 4 | 10,643 | Fergie Jenkins | Steve Stone | Fergie Jenkins | Steve Stone | | 152 | 159 | -7 |
| 1971-05-20 | vs SFN | 39 | L 7-8 | 20-19 | 4 | 16,027 | Ken Holtzman | Juan Marichal | Don McMahon | Ron Tompkins | | 159 | 167 | -8 |
| 1971-05-21 | vs LAN | 40 | L 1-8 | 20-20 | 4 | 11,859 | Bill Hands | Claude Osteen | Claude Osteen | Bill Hands | | 160 | 175 | -15 |
| 1971-05-22 | vs LAN | 41 | W 5-2 | 21-20 | 4 | 27,538 | Milt Pappas | Don Sutton | Milt Pappas | Don Sutton | | 165 | 177 | -12 |
| 1971-05-23 | vs LAN | 42 | L 3-4 | 21-21 | 4 | 27,168 | Fergie Jenkins | Al Downing | Pete Mikkelsen | Fergie Jenkins | Jim Brewer | 168 | 181 | -13 |
| 1971-05-25 | @ SLN | 43 | L 2-4 | 21-22 | 4 | 12,667 | Bill Hands | Steve Carlton | Steve Carlton | Bill Hands | | 170 | 185 | -15 |
| 1971-05-26 | @ SLN | 44 | L 4-9 | 21-23 | 5 | 12,690 | Ken Holtzman | Jerry Reuss | Chuck Taylor | Ken Holtzman | | 174 | 194 | -20 |
| 1971-05-27 | @ SLN | 45 | L 0-10 | 21-24 | 5 | 14,167 | Fergie Jenkins | Chris Zachary | Chris Zachary | Fergie Jenkins | | 174 | 204 | -30 |
| 1971-05-28 | @ PIT | 46 | W 4-2 | 22-24 | 4 | 12,776 | Milt Pappas | Luke Walker | Milt Pappas | Luke Walker | | 178 | 206 | -28 |
| 1971-05-29 | @ PIT | 47 | L 4-9 | 22-25 | 4 | 12,336 | Bill Hands | Bob Johnson | Bob Johnson | Bill Hands | Dave Giusti | 182 | 215 | -33 |
| 1971-05-30 | @ PIT | 48 | L 0-10 | 22-26 | 4 | 14,643 | Ken Holtzman | Bob Moose | Bob Moose | Ken Holtzman | | 182 | 225 | -43 |
| 1971-05-31 | @ PIT | 49 | L 0-6 | 22-27 | 4 | 19,589 | Fergie Jenkins | Steve Blass | Steve Blass | Fergie Jenkins | | 182 | 231 | -49 |
| 1971-06-02 | @ CIN | 50 | W 6-3 | 24-27 | 4 | 0 | Bill Hands | Milt Wilcox | Bill Hands | Clay Carroll | | 188 | 234 | -46 |
| 1971-06-02 | @ CIN | 51 | W 4-1 | 24-27 | 4 | 20,034 | Joe Decker | Don Gullett | Phil Regan | Wayne Granger | Ron Tompkins | 192 | 235 | -43 |
| 1971-06-03 | @ CIN | 52 | W 1-0 | 25-27 | 4 | 11,751 | Ken Holtzman | Gary Nolan | Ken Holtzman | Gary Nolan | | 193 | 235 | -42 |
| 1971-06-04 | @ ATL | 53 | W 11-0 | 26-27 | 4 | 10,761 | Fergie Jenkins | Phil Niekro | Fergie Jenkins | Phil Niekro | | 204 | 235 | -31 |
| 1971-06-05 | @ ATL | 54 | L 4-6 | 26-28 | 4 | 14,024 | Bill Bonham | George Stone | Cecil Upshaw | Phil Regan | | 208 | 241 | -33 |
| 1971-06-06 | @ ATL | 55 | W 6-3 | 27-28 | 4 | 21,533 | Bill Hands | Jim Nash | Bill Hands | Jim Nash | | 214 | 244 | -30 |
| 1971-06-07 | vs PIT | 56 | L 6-11 | 27-29 | 4 | 16,478 | Milt Pappas | Nelson Briles | Bob Veale | Milt Pappas | Dave Giusti | 220 | 255 | -35 |
| 1971-06-08 | vs PIT | 57 | W 1-0 | 28-29 | 4 | 14,878 | Ken Holtzman | Jim Nelson | Ken Holtzman | Mudcat Grant | | 221 | 255 | -34 |
| 1971-06-09 | vs PIT | 58 | W 3-1 | 29-29 | 4 | 16,438 | Fergie Jenkins | Bob Moose | Fergie Jenkins | Bob Moose | | 224 | 256 | -32 |
| 1971-06-11 | vs CIN | 59 | L 3-4 | 29-30 | 4 | 17,871 | Bill Hands | Don Gullett | Wayne Granger | Bill Hands | Joe Gibbon | 227 | 260 | -33 |
| 1971-06-12 | vs CIN | 60 | W 5-2 | 30-30 | 4 | 32,346 | Ken Holtzman | Jim McGlothlin | Ken Holtzman | Jim McGlothlin | Ron Tompkins | 232 | 262 | -30 |
| 1971-06-13 | vs CIN | 61 | L 3-4 | 30-31 | 4 | 35,190 | Fergie Jenkins | Gary Nolan | Wayne Granger | Fergie Jenkins | | 235 | 266 | -31 |
| 1971-06-14 | vs ATL | 62 | W 3-2 | 31-31 | 4 | 14,381 | Phil Regan | Phil Niekro | Phil Regan | Phil Niekro | Ron Tompkins | 238 | 268 | -30 |
| 1971-06-15 | vs ATL | 63 | W 3-1 | 32-31 | 4 | 18,758 | Bill Hands | Tom Kelley | Bill Hands | Tom Kelley | | 241 | 269 | -28 |
| 1971-06-16 | vs ATL | 64 | L 5-6 | 32-32 | 4 | 19,204 | Ken Holtzman | Jim Nash | Jim Nash | Ken Holtzman | Phil Niekro | 246 | 275 | -29 |
| 1971-06-17 | vs SLN | 65 | W 7-6 | 33-32 | 4 | 22,749 | Burt Hooton | Steve Carlton | Bill Bonham | Chris Zachary | | 253 | 281 | -28 |
| 1971-06-18 | vs SLN | 66 | W 15-5 | 34-32 | 4 | 23,540 | Milt Pappas | Jerry Reuss | Milt Pappas | Jerry Reuss | Phil Regan | 268 | 286 | -18 |
| 1971-06-19 | vs SLN | 67 | W 7-1 | 35-32 | 4 | 32,809 | Bill Hands | Reggie Cleveland | Bill Hands | Reggie Cleveland | | 275 | 287 | -12 |
| 1971-06-20 | vs SLN | 68 | L 4-5 | 35-33 | 4 | 34,574 | Ken Holtzman | Al Santorini | Moe Drabowsky | Ken Holtzman | | 279 | 292 | -13 |
| 1971-06-22 | @ SFN | 69 | L 0-2 | 35-34 | 4 | 12,526 | Fergie Jenkins | John Cumberland | John Cumberland | Fergie Jenkins | Jerry Johnson | 279 | 294 | -15 |
| 1971-06-23 | @ SFN | 70 | L 2-5 | 35-35 | 4 | 12,418 | Milt Pappas | Juan Marichal | Juan Marichal | Milt Pappas | | 281 | 299 | -18 |
| 1971-06-25 | @ SLN | 71 | W 12-0 | 36-35 | 4 | 28,743 | Bill Hands | Al Santorini | Bill Bonham | Al Santorini | | 293 | 299 | -6 |
| 1971-06-26 | @ SLN | 72 | W 5-1 | 37-35 | 4 | 43,300 | Ken Holtzman | Bob Gibson | Ken Holtzman | Bob Gibson | | 298 | 300 | -2 |
| 1971-06-27 | @ SLN | 73 | W 4-1 | 38-35 | 3 | 34,964 | Fergie Jenkins | Steve Carlton | Fergie Jenkins | Steve Carlton | | 302 | 301 | 1 |
| 1971-06-28 | vs LAN | 74 | L 4-6 | 38-36 | 3 | 16,567 | Milt Pappas | Al Downing | Al Downing | Milt Pappas | Jim Brewer | 306 | 307 | -1 |
| 1971-06-29 | vs LAN | 75 | W 3-2 | 39-36 | 3 | 16,580 | Bill Hands | Bob O'Brien | Bill Hands | Joe Moeller | Phil Regan | 309 | 309 | 0 |
| 1971-06-30 | vs LAN | 76 | W 10-5 | 40-36 | 3 | 22,283 | Ken Holtzman | Claude Osteen | Ken Holtzman | Claude Osteen | | 319 | 314 | 5 |
| 1971-07-02 | vs PIT | 77 | L 1-5 | 40-37 | 3 | 28,919 | Fergie Jenkins | Bob Moose | Bob Moose | Fergie Jenkins | | 320 | 319 | 1 |
| 1971-07-03 | vs PIT | 78 | W 3-1 | 41-37 | 3 | 31,422 | Milt Pappas | Bob Johnson | Milt Pappas | Bob Johnson | | 323 | 320 | 3 |
| 1971-07-04 | vs PIT | 79 | W 9-7 | 42-37 | 3 | 30,401 | Bill Hands | Bruce Kison | Phil Regan | Dave Giusti | Ray Newman | 332 | 327 | 5 |
| 1971-07-05 | vs PIT | 80 | L 2-6 | 42-38 | 3 | 37,734 | Ken Holtzman | Steve Blass | Steve Blass | Ken Holtzman | | 334 | 333 | 1 |
| 1971-07-06 | @ LAN | 81 | W 3-1 | 43-38 | 3 | 18,671 | Fergie Jenkins | Bob O'Brien | Fergie Jenkins | Bob O'Brien | | 337 | 334 | 3 |
| 1971-07-07 | @ LAN | 82 | W 6-5 | 45-38 | 3 | 0 | Milt Pappas | Al Downing | Milt Pappas | Al Downing | Phil Regan | 343 | 339 | 4 |
| 1971-07-07 | @ LAN | 83 | W 4-3 | 45-38 | 3 | 31,604 | Juan Pizarro | Doyle Alexander | Juan Pizarro | Doyle Alexander | Ray Newman | 347 | 342 | 5 |
| 1971-07-08 | @ LAN | 84 | W 4-2 | 46-38 | 3 | 21,166 | Ken Holtzman | Joe Moeller | Ken Holtzman | Joe Moeller | | 351 | 344 | 7 |
| 1971-07-09 | @ SDN | 85 | L 0-1 | 46-40 | 3 | 0 | Bill Hands | Dave Roberts | Dave Roberts | Bill Hands | Bob Miller | 351 | 345 | 6 |
| 1971-07-09 | @ SDN | 86 | L 2-7 | 46-40 | 3 | 12,465 | Joe Decker | Steve Arlin | Steve Arlin | Joe Decker | | 353 | 352 | 1 |
| 1971-07-10 | @ SDN | 87 | W 3-1 | 47-40 | 3 | 3,423 | Fergie Jenkins | Fred Norman | Fergie Jenkins | Fred Norman | | 356 | 353 | 3 |
| 1971-07-11 | @ SDN | 88 | W 2-0 | 48-41 | 2 | 0 | Milt Pappas | Tom Phoebus | Milt Pappas | Tom Phoebus | | 358 | 353 | 5 |
| 1971-07-11 | @ SDN | 89 | L 5-7 | 48-41 | 2 | 13,274 | Juan Pizarro | Clay Kirby | Clay Kirby | Juan Pizarro | Bob Miller | 363 | 360 | 3 |
| 1971-07-15 | vs PHI | 90 | W 7-6 | 49-41 | 2 | 26,346 | Ken Holtzman | Rick Wise | Joe Decker | Jim Bunning | | 370 | 366 | 4 |
| 1971-07-16 | vs PHI | 91 | W 11-2 | 50-41 | 2 | 23,212 | Fergie Jenkins | Chris Short | Fergie Jenkins | Chris Short | | 381 | 368 | 13 |
| 1971-07-17 | vs PHI | 92 | L 2-5 | 50-42 | 2 | 30,352 | Bill Hands | Woodie Fryman | Woodie Fryman | Bill Hands | Joe Hoerner | 383 | 373 | 10 |
| 1971-07-18 | vs MON | 93 | W 8-4 | 51-42 | 2 | 31,985 | Milt Pappas | Dan McGinn | Ray Newman | Dan McGinn | | 391 | 377 | 14 |
| 1971-07-19 | vs MON | 94 | L 3-5 | 51-43 | 2 | 13,514 | Ken Holtzman | John Strohmayer | John Strohmayer | Ken Holtzman | Mike Marshall | 394 | 382 | 12 |
| 1971-07-20 | vs NYN | 95 | W 4-2 | 52-43 | 2 | 37,270 | Fergie Jenkins | Gary Gentry | Fergie Jenkins | Gary Gentry | | 398 | 384 | 14 |
| 1971-07-21 | vs NYN | 96 | W 11-7 | 53-43 | 2 | 37,828 | Bill Hands | Charlie Williams | Joe Decker | Charlie Williams | Phil Regan | 409 | 391 | 18 |
| 1971-07-22 | vs NYN | 97 | L 1-5 | 53-44 | 2 | 35,459 | Milt Pappas | Tom Seaver | Tom Seaver | Milt Pappas | | 410 | 396 | 14 |
| 1971-07-23 | @ PHI | 98 | L 3-4 | 53-45 | 2 | 48,543 | Ken Holtzman | Ken Reynolds | Ken Reynolds | Ken Holtzman | Bill Wilson | 413 | 400 | 13 |
| 1971-07-24 | @ PHI | 99 | W 2-1 | 54-45 | 2 | 30,240 | Fergie Jenkins | Rick Wise | Fergie Jenkins | Rick Wise | | 415 | 401 | 14 |
| 1971-07-25 | @ PHI | 100 | L 1-2 | 54-46 | 2 | 19,572 | Bill Hands | Chris Short | Bill Wilson | Bill Hands | | 416 | 403 | 13 |
| 1971-07-26 | @ MON | 101 | W 5-2 | 55-46 | 2 | 16,037 | Milt Pappas | Steve Renko | Milt Pappas | Steve Renko | | 421 | 405 | 16 |
| 1971-07-27 | @ MON | 102 | L 1-6 | 55-47 | 2 | 20,401 | Ken Holtzman | Ernie McAnally | Ernie McAnally | Ken Holtzman | | 422 | 411 | 11 |
| 1971-07-28 | @ MON | 103 | W 10-2 | 56-47 | 2 | 17,063 | Fergie Jenkins | Carl Morton | Fergie Jenkins | Carl Morton | | 432 | 413 | 19 |
| 1971-07-30 | @ NYN | 104 | L 0-4 | 56-48 | 3 | 30,638 | Bill Hands | Gary Gentry | Gary Gentry | Bill Hands | | 432 | 417 | 15 |
| 1971-07-31 | @ NYN | 105 | L 2-5 | 56-49 | 3 | 43,844 | Milt Pappas | Ray Sadecki | Ray Sadecki | Milt Pappas | Tug McGraw | 434 | 422 | 12 |
| 1971-08-01 | @ NYN | 106 | W 3-2 | 57-49 | 3 | 43,733 | Juan Pizarro | Tom Seaver | Juan Pizarro | Tom Seaver | | 437 | 424 | 13 |
| 1971-08-02 | @ HOU | 107 | L 1-2 | 57-50 | 3 | 20,020 | Fergie Jenkins | Don Wilson | Don Wilson | Fergie Jenkins | | 438 | 426 | 12 |
| 1971-08-03 | @ HOU | 108 | W 5-0 | 58-50 | 3 | 14,622 | Bill Hands | Larry Dierker | Bill Hands | Larry Dierker | | 443 | 426 | 17 |
| 1971-08-04 | vs SDN | 109 | W 3-0 | 59-50 | 3 | 31,653 | Milt Pappas | Fred Norman | Milt Pappas | Fred Norman | | 446 | 426 | 20 |
| 1971-08-05 | vs SDN | 110 | W 3-0 | 60-50 | 3 | 25,233 | Juan Pizarro | Clay Kirby | Juan Pizarro | Clay Kirby | | 449 | 426 | 23 |
| 1971-08-07 | vs SFN | 111 | W 6-5 | 61-50 | 3 | 36,715 | Fergie Jenkins | Don Carrithers | Fergie Jenkins | Don Carrithers | | 455 | 431 | 24 |
| 1971-08-08 | vs SFN | 112 | L 2-4 | 62-51 | 3 | 0 | Bill Hands | Gaylord Perry | Gaylord Perry | Bill Hands | | 457 | 435 | 22 |
| 1971-08-08 | vs SFN | 113 | W 8-0 | 62-51 | 3 | 43,066 | Milt Pappas | Ron Bryant | Milt Pappas | Ron Bryant | | 465 | 435 | 30 |
| 1971-08-10 | @ PIT | 114 | W 2-1 | 63-51 | 2 | 21,789 | Juan Pizarro | Bruce Kison | Juan Pizarro | Bruce Kison | | 467 | 436 | 31 |
| 1971-08-11 | @ PIT | 115 | L 2-3 | 63-52 | 2 | 24,147 | Fergie Jenkins | Dock Ellis | Dock Ellis | Phil Regan | | 469 | 439 | 30 |
| 1971-08-13 | @ CIN | 116 | L 2-8 | 63-53 | 3 | 26,350 | Bill Hands | Don Gullett | Don Gullett | Bill Hands | Wayne Granger | 471 | 447 | 24 |
| 1971-08-14 | @ CIN | 117 | W 3-1 | 64-53 | 3 | 32,678 | Milt Pappas | Jim McGlothlin | Milt Pappas | Jim McGlothlin | | 474 | 448 | 26 |
| 1971-08-15 | @ CIN | 118 | L 1-5 | 64-54 | 3 | 28,383 | Juan Pizarro | Ross Grimsley | Ross Grimsley | Juan Pizarro | | 475 | 453 | 22 |
| 1971-08-16 | @ ATL | 119 | W 3-0 | 65-54 | 3 | 12,282 | Fergie Jenkins | Tom Kelley | Fergie Jenkins | Tom Kelley | | 478 | 453 | 25 |
| 1971-08-17 | @ ATL | 120 | L 4-5 | 65-55 | 3 | 10,070 | Bill Hands | Ron Reed | Jim Nash | Ray Newman | | 482 | 458 | 24 |
| 1971-08-18 | @ ATL | 121 | W 7-2 | 66-55 | 3 | 13,432 | Milt Pappas | Phil Niekro | Milt Pappas | Phil Niekro | | 489 | 460 | 29 |
| 1971-08-20 | vs HOU | 122 | W 3-2 | 68-55 | 2 | 0 | Fergie Jenkins | Ron Cook | Fergie Jenkins | Ron Cook | | 492 | 462 | 30 |
| 1971-08-20 | vs HOU | 123 | W 5-4 | 68-55 | 2 | 30,711 | Ken Holtzman | Ken Forsch | Phil Regan | George Culver | | 497 | 466 | 31 |
| 1971-08-21 | vs HOU | 124 | L 0-3 | 68-56 | 2 | 26,386 | Bill Hands | Jack Billingham | Jack Billingham | Bill Hands | | 497 | 469 | 28 |
| 1971-08-22 | vs HOU | 125 | L 3-4 | 68-57 | 2 | 28,933 | Milt Pappas | Wade Blasingame | Jim Ray | Milt Pappas | | 500 | 473 | 27 |
| 1971-08-23 | vs CIN | 126 | W 6-3 | 69-57 | 2 | 31,893 | Juan Pizarro | Don Gullett | Juan Pizarro | Don Gullett | | 506 | 476 | 30 |
| 1971-08-24 | vs CIN | 127 | L 4-5 | 69-58 | 3 | 38,065 | Fergie Jenkins | Jim McGlothlin | Jim McGlothlin | Fergie Jenkins | Clay Carroll | 510 | 481 | 29 |
| 1971-08-25 | vs CIN | 128 | L 4-9 | 69-59 | 3 | 33,111 | Bill Hands | Ross Grimsley | Ross Grimsley | Bill Hands | Clay Carroll | 514 | 490 | 24 |
| 1971-08-27 | vs ATL | 129 | W 3-0 | 70-59 | 3 | 23,150 | Milt Pappas | Ron Reed | Milt Pappas | Ron Reed | | 517 | 490 | 27 |
| 1971-08-28 | vs ATL | 130 | L 3-4 | 70-60 | 3 | 34,988 | Fergie Jenkins | Phil Niekro | Phil Niekro | Fergie Jenkins | | 520 | 494 | 26 |
| 1971-08-29 | vs ATL | 131 | L 4-5 | 70-61 | 3 | 29,685 | Juan Pizarro | Tom Kelley | Steve Barber | Juan Pizarro | Jim Nash | 524 | 499 | 25 |
| 1971-08-30 | vs MON | 132 | L 2-6 | 70-62 | 3 | 13,651 | Bill Hands | Steve Renko | Steve Renko | Bill Hands | Mike Marshall | 526 | 505 | 21 |
| 1971-08-31 | vs MON | 133 | W 7-6 | 71-63 | 3 | 0 | Milt Pappas | Carl Morton | Phil Regan | Howie Reed | | 533 | 511 | 22 |
| 1971-08-31 | vs MON | 134 | L 2-11 | 71-63 | 3 | 18,699 | Ken Holtzman | John Strohmayer | John Strohmayer | Ken Holtzman | Mike Marshall | 535 | 522 | 13 |
| 1971-09-01 | vs MON | 135 | W 5-2 | 72-63 | 3 | 11,575 | Fergie Jenkins | Bill Stoneman | Fergie Jenkins | Bill Stoneman | | 540 | 524 | 16 |
| 1971-09-02 | vs MON | 136 | L 5-9 | 72-64 | 3 | 9,402 | Juan Pizarro | Ernie McAnally | Ernie McAnally | Juan Pizarro | Mike Marshall | 545 | 533 | 12 |
| 1971-09-03 | @ SLN | 137 | L 1-6 | 72-65 | 3 | 26,708 | Bill Hands | Reggie Cleveland | Reggie Cleveland | Bill Hands | | 546 | 539 | 7 |
| 1971-09-04 | @ SLN | 138 | W 7-5 | 73-65 | 3 | 31,807 | Milt Pappas | Steve Carlton | Milt Pappas | Steve Carlton | Phil Regan | 553 | 544 | 9 |
| 1971-09-05 | @ SLN | 139 | L 5-12 | 73-66 | 3 | 39,309 | Fergie Jenkins | Jerry Reuss | Jerry Reuss | Fergie Jenkins | Chuck Taylor | 558 | 556 | 2 |
| 1971-09-06 | @ PIT | 140 | L 1-4 | 73-68 | 4 | 39,236 | Juan Pizarro | Nelson Briles | Nelson Briles | Juan Pizarro | | 559 | 560 | -1 |
| 1971-09-06 | @ PIT | 141 | L 5-10 | 73-68 | 4 | 39,236 | Ken Holtzman | Luke Walker | Luke Walker | Ken Holtzman | Bob Moose | 564 | 570 | -6 |
| 1971-09-08 | @ PIT | 142 | L 1-10 | 73-69 | 3 | 15,937 | Milt Pappas | Steve Blass | Steve Blass | Milt Pappas | | 565 | 580 | -15 |
| 1971-09-10 | vs SLN | 143 | L 7-8 | 73-70 | 4 | 6,792 | Fergie Jenkins | Steve Carlton | Stan Williams | Jim Colborn | | 572 | 588 | -16 |
| 1971-09-11 | vs SLN | 144 | W 7-0 | 74-70 | 4 | 24,010 | Juan Pizarro | Jerry Reuss | Juan Pizarro | Jerry Reuss | | 579 | 588 | -9 |
| 1971-09-12 | vs SLN | 145 | L 0-4 | 74-71 | 4 | 24,017 | Ken Holtzman | Bob Gibson | Bob Gibson | Ken Holtzman | | 579 | 592 | -13 |
| 1971-09-13 | vs PIT | 146 | L 1-5 | 74-72 | 4 | 6,477 | Milt Pappas | Steve Blass | Steve Blass | Milt Pappas | | 580 | 597 | -17 |
| 1971-09-14 | vs PIT | 147 | L 3-4 | 74-73 | 4 | 9,706 | Fergie Jenkins | Bob Johnson | Bob Moose | Fergie Jenkins | | 583 | 601 | -18 |
| 1971-09-15 | @ NYN | 148 | W 6-2 | 76-73 | 4 | 0 | Bill Hands | Jerry Koosman | Bill Hands | Jerry Koosman | | 589 | 603 | -14 |
| 1971-09-15 | @ NYN | 149 | W 3-2 | 76-73 | 4 | 21,302 | Burt Hooton | Tug McGraw | Burt Hooton | Danny Frisella | | 592 | 605 | -13 |
| 1971-09-16 | @ NYN | 150 | W 1-0 | 77-73 | 3 | 5,174 | Juan Pizarro | Tom Seaver | Juan Pizarro | Tom Seaver | | 593 | 605 | -12 |
| 1971-09-17 | @ PHI | 151 | W 4-3 | 78-73 | 3 | 13,644 | Joe Decker | Ken Reynolds | Joe Decker | Ken Reynolds | Larry Gura | 597 | 608 | -11 |
| 1971-09-18 | @ PHI | 152 | L 3-4 | 78-74 | 3 | 7,740 | Milt Pappas | Rick Wise | Rick Wise | Phil Regan | | 600 | 612 | -12 |
| 1971-09-19 | @ PHI | 153 | W 6-3 | 79-74 | 3 | 20,815 | Fergie Jenkins | Barry Lersch | Fergie Jenkins | Barry Lersch | | 606 | 615 | -9 |
| 1971-09-21 | vs NYN | 154 | W 3-0 | 80-74 | 3 | 5,464 | Burt Hooton | Tom Seaver | Burt Hooton | Tom Seaver | | 609 | 615 | -6 |
| 1971-09-22 | vs NYN | 155 | W 4-1 | 81-74 | 3 | 4,036 | Bill Hands | Gary Gentry | Bill Hands | Gary Gentry | | 613 | 616 | -3 |
| 1971-09-23 | vs NYN | 156 | L 4-5 | 81-75 | 3 | 2,579 | Juan Pizarro | Nolan Ryan | Nolan Ryan | Juan Pizarro | Tug McGraw | 617 | 621 | -4 |
| 1971-09-24 | vs PHI | 157 | L 1-6 | 81-76 | 3 | 2,183 | Milt Pappas | Barry Lersch | Barry Lersch | Milt Pappas | | 618 | 627 | -9 |
| 1971-09-25 | vs PHI | 158 | W 4-2 | 82-76 | 3 | 8,891 | Fergie Jenkins | Bill Champion | Fergie Jenkins | Bill Champion | | 622 | 629 | -7 |
| 1971-09-26 | vs PHI | 159 | L 1-5 | 82-77 | 3 | 18,505 | Joe Decker | Ken Reynolds | Ken Reynolds | Joe Decker | | 623 | 634 | -11 |
| 1971-09-28 | @ MON | 160 | L 4-5 | 82-78 | 3 | 10,232 | Juan Pizarro | Ernie McAnally | Ernie McAnally | Phil Regan | | 627 | 639 | -12 |
| 1971-09-29 | @ MON | 161 | L 5-6 | 82-79 | 3 | 9,786 | Milt Pappas | Steve Renko | Mike Marshall | Ray Newman | | 632 | 645 | -13 |
| 1971-09-30 | @ MON | 162 | W 5-3 | 83-79 | 3 | 27,274 | Fergie Jenkins | Bill Stoneman | Fergie Jenkins | Bill Stoneman | | 637 | 648 | -11 |