| 1970-04-07 | vs MIN | 1 | L 0-12 | 0-1 | 4 | 11,473 | Tommy John | Jim Perry | Jim Perry | Tommy John | | 0 | 12 | -12 |
| 1970-04-09 | vs MIN | 2 | L 4-6 | 0-2 | 5 | 1,474 | Joe Horlen | Luis Tiant | Stan Williams | Joe Horlen | Steve Barber | 4 | 18 | -14 |
| 1970-04-10 | vs MIL | 3 | W 5-4 | 1-2 | 4 | 1,036 | Gerry Janeski | Gene Brabender | Gerry Janeski | Gene Brabender | Wilbur Wood | 9 | 22 | -13 |
| 1970-04-11 | vs MIL | 4 | L 4-8 | 1-3 | 4 | 2,696 | Billy Wynne | Bobby Bolin | John O'Donoghue | Gene Rounsaville | Bob Locker | 13 | 30 | -17 |
| 1970-04-12 | vs MIL | 5 | L 2-5 | 1-5 | 6 | 0 | Tommy John | Lew Krausse | Lew Krausse | Tommy John | John Gelnar | 15 | 35 | -20 |
| 1970-04-12 | vs MIL | 6 | L 2-16 | 1-5 | 6 | 6,220 | Gerry Arrigo | George Lauzerique | George Lauzerique | Gerry Arrigo | | 17 | 51 | -34 |
| 1970-04-14 | @ CAL | 7 | W 3-1 | 2-5 | 6 | 18,229 | Joe Horlen | Clyde Wright | Joe Horlen | Clyde Wright | Wilbur Wood | 20 | 52 | -32 |
| 1970-04-15 | @ OAK | 8 | W 7-0 | 3-5 | 4 | 2,901 | Gerry Janeski | Chuck Dobson | Gerry Janeski | Chuck Dobson | | 27 | 52 | -25 |
| 1970-04-16 | @ OAK | 9 | L 1-3 | 3-6 | 5 | 2,794 | Tommy John | Blue Moon Odom | Blue Moon Odom | Tommy John | | 28 | 55 | -27 |
| 1970-04-18 | @ MIL | 10 | W 8-5 | 4-6 | 5 | 7,788 | Billy Wynne | Bobby Bolin | Wilbur Wood | John Gelnar | Danny Murphy | 36 | 60 | -24 |
| 1970-04-21 | @ MIN | 11 | L 3-4 | 4-7 | 5 | 3,333 | Tommy John | Jim Kaat | Jim Kaat | Tommy John | Ron Perranoski | 39 | 64 | -25 |
| 1970-04-22 | @ MIN | 12 | L 1-3 | 4-8 | 5 | 3,248 | Joe Horlen | Luis Tiant | Luis Tiant | Joe Horlen | | 40 | 67 | -27 |
| 1970-04-23 | @ MIN | 13 | W 7-5 | 5-8 | 5 | 4,372 | Gerry Janeski | Bill Zepp | Tommie Sisk | Ron Perranoski | Wilbur Wood | 47 | 72 | -25 |
| 1970-04-24 | @ CLE | 14 | L 1-4 | 5-9 | 5 | 3,871 | Gerry Arrigo | Barry Moore | Barry Moore | Gerry Arrigo | Dennis Higgins | 48 | 76 | -28 |
| 1970-04-25 | @ CLE | 15 | L 5-6 | 5-10 | 5 | 3,981 | Tommy John | Steve Hargan | Steve Hargan | Tommy John | Dennis Higgins | 53 | 82 | -29 |
| 1970-04-26 | @ CLE | 16 | W 2-0 | 6-10 | 4 | 12,009 | Joe Horlen | Dean Chance | Joe Horlen | Dean Chance | Wilbur Wood | 55 | 82 | -27 |
| 1970-04-28 | vs BAL | 17 | L 2-4 | 6-11 | 4 | 5,633 | Gerry Janeski | Mike Cuellar | Mike Cuellar | Gerry Janeski | | 57 | 86 | -29 |
| 1970-04-29 | vs BAL | 18 | L 2-18 | 6-12 | 4 | 5,188 | Tommie Sisk | Jim Palmer | Jim Palmer | Tommie Sisk | | 59 | 104 | -45 |
| 1970-04-30 | vs BAL | 19 | W 6-3 | 7-12 | 4 | 1,469 | Tommy John | Tom Phoebus | Tommy John | Tom Phoebus | Wilbur Wood | 65 | 107 | -42 |
| 1970-05-01 | vs DET | 20 | W 13-6 | 8-12 | 4 | 7,265 | Joe Horlen | Les Cain | Joe Horlen | Les Cain | Danny Murphy | 78 | 113 | -35 |
| 1970-05-02 | vs DET | 21 | W 3-2 | 9-12 | 4 | 4,712 | Gerry Janeski | Joe Niekro | Wilbur Wood | Joe Niekro | | 81 | 115 | -34 |
| 1970-05-03 | vs DET | 22 | L 5-6 | 9-13 | 4 | 8,143 | Billy Wynne | Mike Kilkenny | Mike Kilkenny | Billy Wynne | Fred Lasher | 86 | 121 | -35 |
| 1970-05-05 | vs CLE | 23 | W 2-1 | 10-13 | 4 | 2,993 | Tommy John | Dean Chance | Tommy John | Dean Chance | | 88 | 122 | -34 |
| 1970-05-06 | vs CLE | 24 | W 2-1 | 11-13 | 4 | 2,983 | Joe Horlen | Sam McDowell | Joe Horlen | Sam McDowell | | 90 | 123 | -33 |
| 1970-05-08 | @ BAL | 25 | L 1-6 | 11-14 | 4 | 6,913 | Gerry Janeski | Jim Palmer | Jim Palmer | Gerry Janeski | | 91 | 129 | -38 |
| 1970-05-09 | @ BAL | 26 | L 3-4 | 11-15 | 4 | 7,466 | Tommy John | Tom Phoebus | Tom Phoebus | Tommy John | Eddie Watt | 94 | 133 | -39 |
| 1970-05-10 | @ BAL | 27 | L 2-7 | 11-17 | 4 | 0 | Gerry Arrigo | Dave McNally | Dave McNally | Gerry Arrigo | | 96 | 140 | -44 |
| 1970-05-10 | @ BAL | 28 | L 2-4 | 11-17 | 4 | 14,725 | Joe Horlen | Jim Hardin | Dick Hall | Wilbur Wood | | 98 | 144 | -46 |
| 1970-05-11 | @ DET | 29 | W 9-5 | 12-17 | 4 | 17,879 | Billy Wynne | Joe Niekro | Jerry Crider | Joe Niekro | Wilbur Wood | 107 | 149 | -42 |
| 1970-05-12 | @ DET | 30 | W 7-2 | 13-17 | 4 | 7,803 | Gerry Janeski | Les Cain | Gerry Janeski | Les Cain | Wilbur Wood | 114 | 151 | -37 |
| 1970-05-15 | vs KCA | 31 | W 9-3 | 14-17 | 4 | 5,196 | Joe Horlen | Roger Nelson | Joe Horlen | Roger Nelson | | 123 | 154 | -31 |
| 1970-05-16 | vs KCA | 32 | W 6-1 | 15-17 | 4 | 3,655 | Tommy John | Bob Johnson | Tommy John | Bob Johnson | | 129 | 155 | -26 |
| 1970-05-17 | vs KCA | 33 | L 2-3 | 15-19 | 4 | 0 | Gerry Janeski | Dick Drago | Al Fitzmorris | Wilbur Wood | | 131 | 158 | -27 |
| 1970-05-17 | vs KCA | 34 | L 4-8 | 15-19 | 4 | 18,145 | Bart Johnson | Jim Rooker | Jim Rooker | Wilbur Wood | | 135 | 166 | -31 |
| 1970-05-18 | vs CAL | 35 | L 1-6 | 15-20 | 4 | 4,124 | Billy Wynne | Andy Messersmith | Andy Messersmith | Billy Wynne | | 136 | 172 | -36 |
| 1970-05-19 | vs CAL | 36 | L 0-3 | 15-21 | 4 | 4,059 | Joe Horlen | Rudy May | Rudy May | Joe Horlen | | 136 | 175 | -39 |
| 1970-05-20 | vs CAL | 37 | W 3-2 | 16-21 | 4 | 3,712 | Tommy John | Tom Murphy | Tommy John | Tom Murphy | | 139 | 177 | -38 |
| 1970-05-22 | vs OAK | 38 | L 8-9 | 16-22 | 4 | 8,886 | Gerry Janeski | Blue Moon Odom | Paul Lindblad | Wilbur Wood | Mudcat Grant | 147 | 186 | -39 |
| 1970-05-23 | vs OAK | 39 | L 2-12 | 16-23 | 4 | 7,395 | Joe Horlen | Catfish Hunter | Catfish Hunter | Joe Horlen | | 149 | 198 | -49 |
| 1970-05-24 | vs OAK | 40 | L 1-5 | 16-25 | 5 | 0 | Tommy John | Chuck Dobson | Chuck Dobson | Tommy John | | 150 | 203 | -53 |
| 1970-05-24 | vs OAK | 41 | L 2-5 | 16-25 | 5 | 23,196 | Bart Johnson | Blue Moon Odom | Blue Moon Odom | Bart Johnson | Mudcat Grant | 152 | 208 | -56 |
| 1970-05-25 | @ KCA | 42 | L 1-7 | 16-26 | 5 | 6,643 | Jerry Crider | Dave Morehead | Dave Morehead | Jerry Crider | | 153 | 215 | -62 |
| 1970-05-26 | @ KCA | 43 | W 3-1 | 17-26 | 5 | 7,270 | Gerry Janeski | Bob Johnson | Gerry Janeski | Bob Johnson | Wilbur Wood | 156 | 216 | -60 |
| 1970-05-27 | @ KCA | 44 | L 3-4 | 17-27 | 5 | 11,054 | Joe Horlen | Dick Drago | Dick Drago | Joe Horlen | Moe Drabowsky | 159 | 220 | -61 |
| 1970-05-29 | @ BOS | 45 | L 3-4 | 17-28 | 5 | 22,737 | Tommy John | Sonny Siebert | Jim Lonborg | Wilbur Wood | | 162 | 224 | -62 |
| 1970-05-30 | @ BOS | 46 | L 5-7 | 17-29 | 5 | 21,026 | Bart Johnson | Mike Nagy | Vicente Romo | Jerry Crider | Sparky Lyle | 167 | 231 | -64 |
| 1970-05-31 | @ BOS | 47 | W 22-13 | 18-29 | 5 | 21,952 | Gerry Janeski | Gary Peters | Floyd Weaver | Gary Peters | | 189 | 244 | -55 |
| 1970-06-02 | @ WS2 | 48 | L 3-4 | 18-30 | 5 | 7,815 | Joe Horlen | George Brunet | Horacio Pina | Wilbur Wood | Joe Grzenda | 192 | 248 | -56 |
| 1970-06-03 | @ WS2 | 49 | L 4-5 | 18-31 | 5 | 4,678 | Tommy John | Joe Coleman | Joe Coleman | Tommy John | Darold Knowles | 196 | 253 | -57 |
| 1970-06-04 | @ WS2 | 50 | W 7-3 | 19-31 | 5 | 6,270 | Jerry Crider | Dick Bosman | Jerry Crider | Dick Bosman | Danny Murphy | 203 | 256 | -53 |
| 1970-06-05 | @ NYA | 51 | L 1-10 | 19-32 | 5 | 11,772 | Gerry Janeski | Mel Stottlemyre | Mel Stottlemyre | Gerry Janeski | | 204 | 266 | -62 |
| 1970-06-06 | @ NYA | 52 | L 1-3 | 19-33 | 5 | 10,384 | Joe Horlen | John Cumberland | John Cumberland | Joe Horlen | | 205 | 269 | -64 |
| 1970-06-07 | @ NYA | 53 | W 4-3 | 20-33 | 4 | 65,880 | Tommy John | Fritz Peterson | Wilbur Wood | Lindy McDaniel | | 209 | 272 | -63 |
| 1970-06-08 | @ MIL | 54 | L 2-5 | 20-34 | 4 | 7,697 | Bart Johnson | Lew Krausse | Lew Krausse | Bart Johnson | | 211 | 277 | -66 |
| 1970-06-09 | vs BOS | 55 | W 4-2 | 21-34 | 4 | 6,981 | Gerry Janeski | Sonny Siebert | Gerry Janeski | Sonny Siebert | | 215 | 279 | -64 |
| 1970-06-10 | vs BOS | 56 | L 6-7 | 21-35 | 4 | 6,887 | Joe Horlen | Mike Nagy | Vicente Romo | Wilbur Wood | Lee Stange | 221 | 286 | -65 |
| 1970-06-12 | vs WS2 | 57 | W 6-0 | 22-35 | 4 | 7,928 | Tommy John | George Brunet | Tommy John | George Brunet | | 227 | 286 | -59 |
| 1970-06-13 | vs WS2 | 58 | L 7-12 | 22-36 | 4 | 8,281 | Gerry Janeski | Joe Grzenda | Jim Hannan | Gerry Janeski | Darold Knowles | 234 | 298 | -64 |
| 1970-06-14 | vs WS2 | 59 | L 4-8 | 22-38 | 4 | 0 | Joe Horlen | Dick Bosman | Dick Bosman | Joe Horlen | Darold Knowles | 238 | 306 | -68 |
| 1970-06-14 | vs WS2 | 60 | L 3-5 | 22-38 | 4 | 10,049 | Jerry Crider | Casey Cox | Casey Cox | Jerry Crider | Darold Knowles | 241 | 311 | -70 |
| 1970-06-16 | vs NYA | 61 | L 2-6 | 22-39 | 4 | 10,189 | Tommy John | Mel Stottlemyre | Mel Stottlemyre | Tommy John | | 243 | 317 | -74 |
| 1970-06-17 | vs NYA | 62 | W 6-3 | 23-39 | 4 | 8,472 | Gerry Janeski | Fritz Peterson | Gerry Janeski | Fritz Peterson | Wilbur Wood | 249 | 320 | -71 |
| 1970-06-19 | @ OAK | 63 | W 4-2 | 24-39 | 4 | 8,254 | Joe Horlen | Blue Moon Odom | Joe Horlen | Blue Moon Odom | | 253 | 322 | -69 |
| 1970-06-20 | @ OAK | 64 | L 5-8 | 24-40 | 4 | 28,179 | Barry Moore | Chuck Dobson | Mudcat Grant | Barry Moore | | 258 | 330 | -72 |
| 1970-06-21 | @ OAK | 65 | L 3-6 | 24-42 | 5 | 0 | Tommy John | Catfish Hunter | Catfish Hunter | Tommy John | | 261 | 336 | -75 |
| 1970-06-21 | @ OAK | 66 | L 4-5 | 24-42 | 5 | 20,139 | Bob Miller | Rollie Fingers | Rollie Fingers | Bob Miller | Mudcat Grant | 265 | 341 | -76 |
| 1970-06-23 | @ CAL | 67 | W 7-3 | 25-42 | 4 | 9,006 | Gerry Janeski | Andy Messersmith | Gerry Janeski | Andy Messersmith | Wilbur Wood | 272 | 344 | -72 |
| 1970-06-24 | @ CAL | 68 | L 1-3 | 25-44 | 5 | 0 | Joe Horlen | Tom Murphy | Tom Murphy | Joe Horlen | | 273 | 347 | -74 |
| 1970-06-24 | @ CAL | 69 | L 1-2 | 25-44 | 5 | 38,956 | Barry Moore | Mel Queen | Mel Queen | Barry Moore | Eddie Fisher | 274 | 349 | -75 |
| 1970-06-25 | @ CAL | 70 | L 3-7 | 25-45 | 5 | 10,160 | Tommy John | Clyde Wright | Clyde Wright | Tommy John | Ken Tatum | 277 | 356 | -79 |
| 1970-06-26 | vs MIN | 71 | W 4-2 | 26-45 | 4 | 9,486 | Bob Miller | Jim Kaat | Bob Miller | Jim Kaat | Jerry Crider | 281 | 358 | -77 |
| 1970-06-27 | vs MIN | 72 | L 1-9 | 26-46 | 6 | 19,113 | Gerry Janeski | Bert Blyleven | Bert Blyleven | Gerry Janeski | | 282 | 367 | -85 |
| 1970-06-28 | vs MIN | 73 | L 1-9 | 27-47 | 5 | 0 | Joe Horlen | Tom Hall | Tom Hall | Joe Horlen | Bill Zepp | 283 | 376 | -93 |
| 1970-06-28 | vs MIN | 74 | W 11-10 | 27-47 | 5 | 24,288 | Barry Moore | Dave Boswell | Danny Murphy | Dick Woodson | Wilbur Wood | 294 | 386 | -92 |
| 1970-06-30 | vs OAK | 75 | L 3-4 | 27-48 | 5 | 5,751 | Tommy John | Catfish Hunter | Catfish Hunter | Tommy John | Mudcat Grant | 297 | 390 | -93 |
| 1970-07-01 | vs OAK | 76 | L 0-3 | 27-49 | 5 | 7,842 | Gerry Janeski | Rollie Fingers | Rollie Fingers | Gerry Janeski | Mudcat Grant | 297 | 393 | -96 |
| 1970-07-02 | vs OAK | 77 | L 6-10 | 27-50 | 5 | 4,697 | Barry Moore | Diego Segui | Marcel Lachemann | Barry Moore | Bob Locker | 303 | 403 | -100 |
| 1970-07-03 | @ MIN | 78 | L 2-8 | 27-51 | 5 | 13,286 | Joe Horlen | Jim Perry | Jim Perry | Joe Horlen | | 305 | 411 | -106 |
| 1970-07-04 | @ MIN | 79 | W 5-3 | 28-51 | 5 | 20,935 | Tommy John | Dave Boswell | Wilbur Wood | Dick Woodson | Jerry Crider | 310 | 414 | -104 |
| 1970-07-05 | @ MIN | 80 | L 3-12 | 28-52 | 5 | 18,324 | Bob Miller | Jim Kaat | Jim Kaat | Bob Miller | Stan Williams | 313 | 426 | -113 |
| 1970-07-06 | @ MIL | 81 | L 1-3 | 28-53 | 6 | 11,364 | Gerry Janeski | Gene Brabender | Gene Brabender | Gerry Janeski | | 314 | 429 | -115 |
| 1970-07-07 | @ MIL | 82 | L 3-4 | 28-55 | 6 | 0 | Jim Magnuson | Marty Pattin | Marty Pattin | Wilbur Wood | | 317 | 433 | -116 |
| 1970-07-07 | @ MIL | 83 | L 0-1 | 28-55 | 6 | 15,280 | Joe Horlen | Lew Krausse | Lew Krausse | Joe Horlen | | 317 | 434 | -117 |
| 1970-07-08 | @ MIL | 84 | W 2-1 | 29-55 | 6 | 12,119 | Tommy John | Al Downing | Tommy John | Al Downing | | 319 | 435 | -116 |
| 1970-07-09 | @ MIL | 85 | W 6-5 | 30-55 | 6 | 14,288 | Jerry Crider | Skip Lockwood | Jerry Crider | Skip Lockwood | Danny Murphy | 325 | 440 | -115 |
| 1970-07-10 | @ KCA | 86 | L 6-8 | 30-57 | 6 | 0 | Gerry Janeski | Bob Johnson | Bob Johnson | Gerry Janeski | Ted Abernathy | 331 | 448 | -117 |
| 1970-07-10 | @ KCA | 87 | L 0-2 | 30-57 | 6 | 12,463 | Bob Miller | Jim Rooker | Jim Rooker | Bob Miller | | 331 | 450 | -119 |
| 1970-07-11 | @ KCA | 88 | L 0-4 | 30-58 | 6 | 10,494 | Joe Horlen | Bill Butler | Bill Butler | Joe Horlen | | 331 | 454 | -123 |
| 1970-07-12 | @ KCA | 89 | W 10-5 | 31-58 | 6 | 10,565 | Tommy John | Dick Drago | Tommy John | Dick Drago | Jerry Crider | 341 | 459 | -118 |
| 1970-07-16 | vs DET | 90 | L 6-11 | 31-59 | 6 | 6,666 | Gerry Janeski | Les Cain | Fred Scherman | Gerry Janeski | Tom Timmermann | 347 | 470 | -123 |
| 1970-07-17 | vs DET | 91 | L 3-4 | 31-60 | 6 | 13,473 | Tommy John | Denny McLain | Tom Timmermann | Wilbur Wood | John Hiller | 350 | 474 | -124 |
| 1970-07-18 | vs DET | 92 | L 4-5 | 31-61 | 6 | 10,288 | Jim Magnuson | Mickey Lolich | Mickey Lolich | Jim Magnuson | | 354 | 479 | -125 |
| 1970-07-19 | vs BAL | 93 | L 2-8 | 32-62 | 6 | 0 | Joe Horlen | Jim Palmer | Jim Palmer | Joe Horlen | | 356 | 487 | -131 |
| 1970-07-19 | vs BAL | 94 | W 7-3 | 32-62 | 6 | 18,587 | Bob Miller | Tom Phoebus | Bob Miller | Tom Phoebus | Jerry Crider | 363 | 490 | -127 |
| 1970-07-20 | vs BAL | 95 | L 5-14 | 32-63 | 6 | 5,130 | Gerry Janeski | Mike Cuellar | Mike Cuellar | Gerry Janeski | | 368 | 504 | -136 |
| 1970-07-21 | @ CLE | 96 | W 5-3 | 33-63 | 6 | 12,011 | Tommy John | Steve Dunning | Tommy John | Steve Dunning | | 373 | 507 | -134 |
| 1970-07-22 | @ CLE | 97 | L 2-6 | 33-64 | 6 | 5,590 | Jim Magnuson | Steve Hargan | Steve Hargan | Jim Magnuson | Fred Lasher | 375 | 513 | -138 |
| 1970-07-23 | @ CLE | 98 | L 2-5 | 33-65 | 6 | 7,369 | Joe Horlen | Sam McDowell | Sam McDowell | Joe Horlen | | 377 | 518 | -141 |
| 1970-07-24 | @ DET | 99 | W 5-2 | 34-66 | 6 | 0 | Bob Miller | Les Cain | Lee Stange | Tom Timmermann | Wilbur Wood | 382 | 520 | -138 |
| 1970-07-24 | @ DET | 100 | L 4-5 | 34-66 | 6 | 36,621 | Gerry Janeski | Mike Kilkenny | John Hiller | Wilbur Wood | | 386 | 525 | -139 |
| 1970-07-25 | @ DET | 101 | L 4-9 | 34-67 | 6 | 30,080 | Jerry Crider | Denny McLain | Denny McLain | Jerry Crider | Tom Timmermann | 390 | 534 | -144 |
| 1970-07-26 | @ DET | 102 | W 4-0 | 35-67 | 6 | 49,631 | Tommy John | Mickey Lolich | Tommy John | Mickey Lolich | | 394 | 534 | -140 |
| 1970-07-28 | @ BAL | 103 | L 2-4 | 35-68 | 6 | 23,913 | Joe Horlen | Mike Cuellar | Mike Cuellar | Joe Horlen | | 396 | 538 | -142 |
| 1970-07-29 | @ BAL | 104 | W 2-1 | 36-68 | 6 | 15,302 | Bob Miller | Jim Hardin | Wilbur Wood | Jim Hardin | | 398 | 539 | -141 |
| 1970-07-31 | vs CLE | 105 | W 5-4 | 37-68 | 6 | 5,467 | Tommy John | Steve Dunning | Danny Murphy | Dick Ellsworth | | 403 | 543 | -140 |
| 1970-08-01 | vs CLE | 106 | L 2-3 | 37-69 | 6 | 4,945 | Gerry Janeski | Sam McDowell | Sam McDowell | Gerry Janeski | | 405 | 546 | -141 |
| 1970-08-02 | vs CLE | 107 | L 2-4 | 38-70 | 6 | 0 | Jerry Crider | Rich Hand | Rich Hand | Jerry Crider | Dennis Higgins | 407 | 550 | -143 |
| 1970-08-02 | vs CLE | 108 | W 8-7 | 38-70 | 6 | 9,485 | Floyd Weaver | Dean Chance | Wilbur Wood | Dick Ellsworth | | 415 | 557 | -142 |
| 1970-08-03 | vs KCA | 109 | L 2-7 | 38-71 | 6 | 3,587 | Bob Miller | Bob Johnson | Bob Johnson | Bob Miller | | 417 | 564 | -147 |
| 1970-08-04 | vs KCA | 110 | W 2-1 | 39-71 | 6 | 4,533 | Tommy John | Bill Butler | Tommy John | Bill Butler | | 419 | 565 | -146 |
| 1970-08-05 | vs MIL | 111 | W 9-3 | 40-71 | 6 | 4,583 | Jim Magnuson | Gene Brabender | Jim Magnuson | Gene Brabender | Danny Murphy | 428 | 568 | -140 |
| 1970-08-06 | vs MIL | 112 | W 7-3 | 41-71 | 5 | 4,725 | Gerry Janeski | Al Downing | Gerry Janeski | Al Downing | Wilbur Wood | 435 | 571 | -136 |
| 1970-08-07 | vs CAL | 113 | L 4-6 | 41-72 | 5 | 12,730 | Bart Johnson | Tom Bradley | Eddie Fisher | Danny Murphy | | 439 | 577 | -138 |
| 1970-08-08 | vs CAL | 114 | W 8-1 | 42-72 | 5 | 2,679 | Bob Miller | Rudy May | Bob Miller | Rudy May | Wilbur Wood | 447 | 578 | -131 |
| 1970-08-09 | vs CAL | 115 | L 0-5 | 42-74 | 6 | 0 | Tommy John | Clyde Wright | Clyde Wright | Tommy John | Mel Queen | 447 | 583 | -136 |
| 1970-08-09 | vs CAL | 116 | L 3-6 | 42-74 | 6 | 8,502 | Jerry Crider | Tom Murphy | Tom Murphy | Jerry Crider | Eddie Fisher | 450 | 589 | -139 |
| 1970-08-11 | @ NYA | 117 | L 1-7 | 42-75 | 6 | 13,454 | Gerry Janeski | Mel Stottlemyre | Mel Stottlemyre | Gerry Janeski | | 451 | 596 | -145 |
| 1970-08-12 | @ NYA | 118 | W 5-1 | 43-75 | 6 | 12,440 | Bart Johnson | Stan Bahnsen | Bart Johnson | Stan Bahnsen | Wilbur Wood | 456 | 597 | -141 |
| 1970-08-13 | @ NYA | 119 | L 3-4 | 43-76 | 6 | 9,902 | Bob Miller | Mike McCormick | Jack Aker | Floyd Weaver | | 459 | 601 | -142 |
| 1970-08-14 | @ WS2 | 120 | L 5-6 | 43-77 | 6 | 5,140 | Tommy John | Joe Coleman | Joe Grzenda | Wilbur Wood | | 464 | 607 | -143 |
| 1970-08-15 | @ WS2 | 121 | L 2-4 | 43-78 | 6 | 8,610 | Barry Moore | Jackie Brown | Jackie Brown | Jerry Crider | | 466 | 611 | -145 |
| 1970-08-16 | @ WS2 | 122 | L 1-2 | 43-79 | 6 | 8,457 | Gerry Janeski | Casey Cox | Casey Cox | Gerry Janeski | Darold Knowles | 467 | 613 | -146 |
| 1970-08-17 | @ BOS | 123 | L 2-7 | 43-80 | 6 | 12,658 | Bart Johnson | Cal Koonce | Cal Koonce | Bart Johnson | Sparky Lyle | 469 | 620 | -151 |
| 1970-08-18 | @ BOS | 124 | L 4-8 | 43-81 | 6 | 25,592 | Bob Miller | Vicente Romo | Ken Brett | Bob Miller | | 473 | 628 | -155 |
| 1970-08-19 | @ BOS | 125 | W 13-5 | 44-81 | 6 | 17,113 | Tommy John | Ray Culp | Wilbur Wood | Ray Culp | | 486 | 633 | -147 |
| 1970-08-21 | vs NYA | 126 | L 2-4 | 44-82 | 6 | 12,263 | Gerry Janeski | Steve Kline | Steve Kline | Gerry Janeski | Lindy McDaniel | 488 | 637 | -149 |
| 1970-08-22 | vs NYA | 127 | W 3-2 | 45-82 | 6 | 5,367 | Bart Johnson | Stan Bahnsen | Bart Johnson | Stan Bahnsen | Wilbur Wood | 491 | 639 | -148 |
| 1970-08-23 | vs NYA | 128 | W 2-0 | 46-83 | 6 | 0 | Tommy John | Fritz Peterson | Tommy John | Fritz Peterson | | 493 | 639 | -146 |
| 1970-08-23 | vs NYA | 129 | L 5-7 | 46-83 | 6 | 17,200 | Bob Miller | Mike Kekich | Mike Kekich | Bob Miller | Lindy McDaniel | 498 | 646 | -148 |
| 1970-08-25 | vs WS2 | 130 | W 4-3 | 47-83 | 6 | 6,774 | Barry Moore | Joe Coleman | Wilbur Wood | Darold Knowles | | 502 | 649 | -147 |
| 1970-08-26 | vs WS2 | 131 | W 3-1 | 48-83 | 6 | 3,742 | Gerry Janeski | Casey Cox | Gerry Janeski | Casey Cox | Wilbur Wood | 505 | 650 | -145 |
| 1970-08-28 | vs BOS | 132 | L 4-5 | 48-84 | 6 | 12,479 | Tommy John | Gary Peters | Gary Peters | Tommy John | Gary Wagner | 509 | 655 | -146 |
| 1970-08-29 | vs BOS | 133 | W 13-9 | 49-84 | 6 | 6,032 | Bart Johnson | Cal Koonce | Bob Miller | Chuck Hartenstein | Wilbur Wood | 522 | 664 | -142 |
| 1970-08-30 | vs BOS | 134 | L 11-21 | 49-86 | 6 | 0 | Gerry Janeski | Vicente Romo | Ken Brett | Gerry Janeski | Sparky Lyle | 533 | 685 | -152 |
| 1970-08-30 | vs BOS | 135 | L 1-4 | 49-86 | 6 | 8,552 | Jim Magnuson | Mike Nagy | Mike Nagy | Jim Magnuson | | 534 | 689 | -155 |
| 1970-09-01 | @ OAK | 136 | L 5-6 | 49-87 | 6 | 10,604 | Tommy John | Chuck Dobson | Paul Lindblad | Wilbur Wood | | 539 | 695 | -156 |
| 1970-09-02 | @ OAK | 137 | L 1-2 | 49-88 | 6 | 9,932 | Bart Johnson | Blue Moon Odom | Blue Moon Odom | Bart Johnson | Mudcat Grant | 540 | 697 | -157 |
| 1970-09-03 | @ OAK | 138 | L 3-4 | 49-89 | 6 | 9,692 | Jerry Crider | Diego Segui | Bob Locker | Wilbur Wood | | 543 | 701 | -158 |
| 1970-09-04 | @ MIL | 139 | L 2-3 | 49-90 | 6 | 11,953 | Gerry Janeski | Skip Lockwood | Ken Sanders | Danny Murphy | | 545 | 704 | -159 |
| 1970-09-07 | vs OAK | 140 | L 4-7 | 49-92 | 6 | 0 | Tommy John | Vida Blue | Rollie Fingers | Tommy John | | 549 | 711 | -162 |
| 1970-09-07 | vs OAK | 141 | L 5-7 | 49-92 | 6 | 6,115 | Bart Johnson | Diego Segui | Diego Segui | Bart Johnson | Paul Lindblad | 554 | 718 | -164 |
| 1970-09-09 | vs CAL | 142 | W 11-4 | 51-92 | 6 | 0 | Gerry Janeski | Tom Murphy | Gerry Janeski | Tom Murphy | | 565 | 722 | -157 |
| 1970-09-09 | vs CAL | 143 | W 3-1 | 51-92 | 6 | 3,735 | Billy Wynne | Clyde Wright | Billy Wynne | Clyde Wright | Wilbur Wood | 568 | 723 | -155 |
| 1970-09-11 | @ MIN | 144 | L 0-6 | 51-93 | 6 | 10,575 | Barry Moore | Bill Zepp | Bill Zepp | Barry Moore | | 568 | 729 | -161 |
| 1970-09-12 | @ MIN | 145 | W 5-3 | 52-93 | 6 | 14,181 | Bart Johnson | Bert Blyleven | Bart Johnson | Bert Blyleven | Wilbur Wood | 573 | 732 | -159 |
| 1970-09-13 | @ MIN | 146 | W 8-7 | 53-93 | 6 | 21,191 | Billy Wynne | Jim Perry | Jerry Crider | Stan Williams | Wilbur Wood | 581 | 739 | -158 |
| 1970-09-18 | vs MIN | 147 | L 4-5 | 53-94 | 6 | 5,403 | Bart Johnson | Bill Zepp | Bill Zepp | Bart Johnson | Ron Perranoski | 585 | 744 | -159 |
| 1970-09-19 | vs MIN | 148 | L 3-5 | 53-95 | 6 | 4,183 | Tommy John | Tom Hall | Tom Hall | Tommy John | Stan Williams | 588 | 749 | -161 |
| 1970-09-20 | vs MIN | 149 | L 1-8 | 53-96 | 6 | 5,313 | Gerry Janeski | Bert Blyleven | Bert Blyleven | Gerry Janeski | | 589 | 757 | -168 |
| 1970-09-21 | vs KCA | 150 | W 8-4 | 54-97 | 6 | 0 | Joe Horlen | Jim Rooker | Wilbur Wood | Aurelio Monteagudo | | 597 | 761 | -164 |
| 1970-09-21 | vs KCA | 151 | L 2-8 | 54-97 | 6 | 672 | Floyd Weaver | Bill Butler | Jim York | Floyd Weaver | | 599 | 769 | -170 |
| 1970-09-22 | vs KCA | 152 | L 1-2 | 54-99 | 6 | 0 | Billy Wynne | Dick Drago | Dick Drago | Billy Wynne | Ted Abernathy | 600 | 771 | -171 |
| 1970-09-22 | vs KCA | 153 | L 2-6 | 54-99 | 6 | 2,369 | Jim Magnuson | Al Fitzmorris | Al Fitzmorris | Jim Magnuson | | 602 | 777 | -175 |
| 1970-09-23 | vs KCA | 154 | W 6-0 | 55-99 | 6 | 693 | Bart Johnson | Paul Splittorff | Bart Johnson | Paul Splittorff | | 608 | 777 | -169 |
| 1970-09-25 | vs MIL | 155 | W 5-1 | 56-100 | 6 | 0 | Tommy John | Skip Lockwood | Tommy John | Skip Lockwood | | 613 | 778 | -165 |
| 1970-09-25 | vs MIL | 156 | L 2-3 | 56-100 | 6 | 3,826 | Gerry Janeski | Bob Humphreys | Bob Humphreys | Gerry Janeski | Dick Ellsworth | 615 | 781 | -166 |
| 1970-09-26 | vs MIL | 157 | L 5-9 | 56-101 | 6 | 1,602 | Floyd Weaver | Lew Krausse | John Morris | Danny Murphy | Gene Brabender | 620 | 790 | -170 |
| 1970-09-27 | vs MIL | 158 | L 3-9 | 56-102 | 6 | 3,094 | Joe Horlen | Marty Pattin | Marty Pattin | Joe Horlen | | 623 | 799 | -176 |
| 1970-09-28 | @ CAL | 159 | L 3-4 | 56-103 | 6 | 4,170 | Bart Johnson | Tom Murphy | Tom Murphy | Bart Johnson | Eddie Fisher | 626 | 803 | -177 |
| 1970-09-29 | @ CAL | 160 | L 2-9 | 56-104 | 6 | 4,506 | Billy Wynne | Clyde Wright | Clyde Wright | Billy Wynne | | 628 | 812 | -184 |
| 1970-09-30 | @ CAL | 161 | L 1-5 | 56-105 | 6 | 4,530 | Tommy John | Lloyd Allen | Lloyd Allen | Tommy John | Dave LaRoche | 629 | 817 | -188 |
| 1970-10-01 | @ CAL | 162 | L 4-5 | 56-106 | 6 | 5,689 | Gerry Janeski | Greg Garrett | Rudy May | Jim Magnuson | | 633 | 822 | -189 |