| 1969-04-08 | vs BOS | 1 | L 4-5 | 0-1 | 4 | 36,100 | Dave McNally | Jim Lonborg | Bill Landis | Mike Adamson | Juan Pizarro | 4 | 5 | -1 |
| 1969-04-10 | vs BOS | 2 | W 2-1 | 1-1 | 3 | 3,091 | Mike Cuellar | Ray Culp | Dave Leonhard | Juan Pizarro | | 6 | 6 | 0 |
| 1969-04-11 | vs WS2 | 3 | L 0-4 | 1-2 | 5 | 8,415 | Jim Hardin | Barry Moore | Barry Moore | Jim Hardin | Dennis Higgins | 6 | 10 | -4 |
| 1969-04-12 | vs WS2 | 4 | W 9-0 | 2-2 | 4 | 6,379 | Dave McNally | Camilo Pascual | Dave McNally | Camilo Pascual | | 15 | 10 | 5 |
| 1969-04-13 | vs WS2 | 5 | W 2-0 | 4-2 | 2 | 0 | Jim Palmer | Joe Coleman | Jim Palmer | Joe Coleman | | 17 | 10 | 7 |
| 1969-04-13 | vs WS2 | 6 | W 9-0 | 4-2 | 2 | 20,483 | Tom Phoebus | Dick Bosman | Tom Phoebus | Dick Bosman | | 26 | 10 | 16 |
| 1969-04-14 | @ BOS | 7 | L 3-5 | 4-3 | 3 | 33,899 | Mike Cuellar | Ray Culp | Ray Culp | Mike Cuellar | Sparky Lyle | 29 | 15 | 14 |
| 1969-04-15 | @ BOS | 8 | W 10-5 | 5-3 | 2 | 9,673 | Jim Hardin | Dick Ellsworth | Pete Richert | Bill Landis | | 39 | 20 | 19 |
| 1969-04-16 | @ BOS | 9 | W 11-8 | 6-3 | 1 | 8,328 | Dave McNally | Ken Brett | Dave Leonhard | Ken Brett | Dick Hall | 50 | 28 | 22 |
| 1969-04-17 | @ BOS | 10 | W 9-5 | 7-3 | 1 | 8,910 | Jim Palmer | Lee Stange | Jim Palmer | Lee Stange | Eddie Watt | 59 | 33 | 26 |
| 1969-04-18 | @ WS2 | 11 | W 6-0 | 8-3 | 1 | 4,457 | Tom Phoebus | Joe Coleman | Tom Phoebus | Joe Coleman | | 65 | 33 | 32 |
| 1969-04-19 | @ WS2 | 12 | L 5-7 | 8-4 | 1 | 5,495 | Mike Cuellar | Dick Bosman | Dick Bosman | Mike Cuellar | Dennis Higgins | 70 | 40 | 30 |
| 1969-04-20 | @ WS2 | 13 | W 2-1 | 9-5 | 1 | 0 | Dave McNally | Jim Hannan | Dave McNally | Jim Hannan | Eddie Watt | 72 | 41 | 31 |
| 1969-04-20 | @ WS2 | 14 | L 2-5 | 9-5 | 1 | 18,055 | Jim Hardin | Frank Bertaina | Frank Bertaina | Jim Hardin | Bob Humphreys | 74 | 46 | 28 |
| 1969-04-21 | vs CLE | 15 | W 11-0 | 10-5 | 1 | 3,176 | Jim Palmer | Sam McDowell | Jim Palmer | Sam McDowell | | 85 | 46 | 39 |
| 1969-04-22 | vs CLE | 16 | W 3-2 | 11-5 | 1 | 2,337 | Tom Phoebus | Stan Williams | Tom Phoebus | Stan Williams | Pete Richert | 88 | 48 | 40 |
| 1969-04-23 | vs DET | 17 | W 3-2 | 12-5 | 1 | 5,342 | Mike Cuellar | Denny McLain | Mike Cuellar | Denny McLain | | 91 | 50 | 41 |
| 1969-04-24 | vs DET | 18 | W 5-2 | 13-5 | 1 | 4,433 | Dave McNally | Earl Wilson | Dave McNally | Earl Wilson | | 96 | 52 | 44 |
| 1969-04-25 | vs NYA | 19 | L 2-7 | 13-6 | 1 | 11,189 | Jim Hardin | Mel Stottlemyre | Mel Stottlemyre | Jim Hardin | | 98 | 59 | 39 |
| 1969-04-26 | vs NYA | 20 | L 5-6 | 13-7 | 1 | 21,645 | Jim Palmer | Bill Burbach | Lindy McDaniel | Pete Richert | | 103 | 65 | 38 |
| 1969-04-27 | vs NYA | 21 | W 6-0 | 15-7 | 1 | 0 | Mike Cuellar | Stan Bahnsen | Mike Cuellar | Stan Bahnsen | | 109 | 65 | 44 |
| 1969-04-27 | vs NYA | 22 | W 10-5 | 15-7 | 1 | 30,254 | Tom Phoebus | Mike Kekich | Dick Hall | Lindy McDaniel | | 119 | 70 | 49 |
| 1969-04-30 | @ DET | 23 | W 3-2 | 16-7 | 1 | 15,340 | Dave McNally | Pat Dobson | Dave McNally | Pat Dobson | Pete Richert | 122 | 72 | 50 |
| 1969-05-01 | @ DET | 24 | L 0-2 | 16-8 | 1 | 15,731 | Jim Palmer | Denny McLain | Denny McLain | Jim Palmer | | 122 | 74 | 48 |
| 1969-05-02 | @ NYA | 25 | W 5-1 | 17-8 | 1 | 15,841 | Mike Cuellar | Fritz Peterson | Mike Cuellar | Fritz Peterson | | 127 | 75 | 52 |
| 1969-05-03 | @ NYA | 26 | W 5-4 | 18-8 | 1 | 29,059 | Tom Phoebus | Mel Stottlemyre | Dick Hall | Lindy McDaniel | | 132 | 79 | 53 |
| 1969-05-04 | @ NYA | 27 | W 5-3 | 20-8 | 1 | 0 | Dave McNally | Bill Burbach | Dave McNally | Bill Burbach | Pete Richert | 137 | 82 | 55 |
| 1969-05-04 | @ NYA | 28 | W 14-2 | 20-8 | 1 | 31,809 | Jim Hardin | Mike Kekich | Jim Hardin | Mike Kekich | | 151 | 84 | 67 |
| 1969-05-06 | vs CHA | 29 | L 0-1 | 20-9 | 1 | 8,193 | Jim Palmer | Joe Horlen | Joe Horlen | Jim Palmer | | 151 | 85 | 66 |
| 1969-05-07 | vs CHA | 30 | L 4-6 | 20-10 | 1 | 6,860 | Mike Cuellar | Gary Peters | Gary Peters | Mike Cuellar | Bob Locker | 155 | 91 | 64 |
| 1969-05-09 | vs KCA | 31 | L 2-4 | 20-11 | 1 | 7,650 | Tom Phoebus | Dick Drago | Dick Drago | Dick Hall | | 157 | 95 | 62 |
| 1969-05-10 | vs KCA | 32 | W 6-5 | 21-11 | 1 | 6,843 | Dave McNally | Mike Hedlund | Jim Hardin | Moe Drabowsky | | 163 | 100 | 63 |
| 1969-05-11 | vs KCA | 33 | W 5-0 | 22-11 | 1 | 9,736 | Jim Palmer | Roger Nelson | Jim Palmer | Roger Nelson | | 168 | 100 | 68 |
| 1969-05-13 | @ MIN | 34 | L 2-4 | 22-12 | 1 | 13,737 | Mike Cuellar | Dave Boswell | Dave Boswell | Mike Cuellar | Ron Perranoski | 170 | 104 | 66 |
| 1969-05-14 | @ MIN | 35 | W 9-8 | 23-12 | 1 | 17,696 | Tom Phoebus | Dick Woodson | Tom Phoebus | Dick Woodson | Eddie Watt | 179 | 112 | 67 |
| 1969-05-15 | @ MIN | 36 | W 5-0 | 24-12 | 1 | 11,423 | Dave McNally | Jim Kaat | Dave McNally | Jim Kaat | | 184 | 112 | 72 |
| 1969-05-16 | @ KCA | 37 | W 5-3 | 25-12 | 1 | 15,487 | Jim Hardin | Roger Nelson | Eddie Watt | Steve Jones | | 189 | 115 | 74 |
| 1969-05-17 | @ KCA | 38 | W 4-2 | 26-12 | 1 | 12,441 | Jim Palmer | Bill Butler | Jim Palmer | Bill Butler | | 193 | 117 | 76 |
| 1969-05-18 | @ KCA | 39 | W 5-0 | 27-12 | 1 | 28,944 | Mike Cuellar | Dick Drago | Mike Cuellar | Dick Drago | | 198 | 117 | 81 |
| 1969-05-20 | vs MIN | 40 | L 2-3 | 27-13 | 1 | 11,489 | Dave McNally | Jim Kaat | Jim Kaat | Marcelino Lopez | Ron Perranoski | 200 | 120 | 80 |
| 1969-05-21 | vs MIN | 41 | W 4-3 | 28-13 | 1 | 8,076 | Tom Phoebus | Dave Boswell | Tom Phoebus | Dave Boswell | Pete Richert | 204 | 123 | 81 |
| 1969-05-22 | vs MIN | 42 | W 6-2 | 29-13 | 1 | 8,493 | Jim Hardin | Jim Perry | Dick Hall | Ron Perranoski | Eddie Watt | 210 | 125 | 85 |
| 1969-05-23 | vs OAK | 43 | W 4-3 | 30-13 | 1 | 12,130 | Jim Palmer | Blue Moon Odom | Dave Leonhard | Blue Moon Odom | | 214 | 128 | 86 |
| 1969-05-24 | vs OAK | 44 | W 2-1 | 31-13 | 1 | 9,994 | Mike Cuellar | Catfish Hunter | Mike Cuellar | Catfish Hunter | | 216 | 129 | 87 |
| 1969-05-25 | vs OAK | 45 | W 5-3 | 32-13 | 1 | 32,860 | Dave McNally | Jim Nash | Marcelino Lopez | Lew Krausse | Eddie Watt | 221 | 132 | 89 |
| 1969-05-27 | @ SE1 | 46 | L 1-8 | 32-14 | 1 | 8,308 | Tom Phoebus | Gene Brabender | Gene Brabender | Tom Phoebus | | 222 | 140 | 82 |
| 1969-05-28 | @ SE1 | 47 | W 9-5 | 33-14 | 1 | 21,679 | Dave McNally | Mike Marshall | Dave McNally | Mike Marshall | Pete Richert | 231 | 145 | 86 |
| 1969-05-30 | @ CAL | 48 | W 3-1 | 34-14 | 1 | 14,097 | Mike Cuellar | Andy Messersmith | Mike Cuellar | Andy Messersmith | | 234 | 146 | 88 |
| 1969-05-31 | @ CAL | 49 | L 3-4 | 34-15 | 1 | 13,412 | Tom Phoebus | George Brunet | Ken Tatum | Eddie Watt | | 237 | 150 | 87 |
| 1969-06-01 | @ CAL | 50 | W 4-3 | 35-15 | 1 | 11,403 | Dave McNally | Jim McGlothlin | Jim Palmer | Bob Priddy | | 241 | 153 | 88 |
| 1969-06-03 | @ OAK | 51 | W 3-1 | 36-15 | 1 | 6,470 | Mike Cuellar | Blue Moon Odom | Eddie Watt | Lew Krausse | | 244 | 154 | 90 |
| 1969-06-04 | @ OAK | 52 | W 6-1 | 37-15 | 1 | 5,549 | Tom Phoebus | Catfish Hunter | Tom Phoebus | Catfish Hunter | | 250 | 155 | 95 |
| 1969-06-06 | vs SE1 | 53 | W 5-1 | 38-15 | 1 | 17,689 | Dave McNally | Gary Bell | Dave McNally | Gary Bell | | 255 | 156 | 99 |
| 1969-06-07 | vs SE1 | 54 | W 10-0 | 39-15 | 1 | 13,903 | Jim Palmer | Gene Brabender | Jim Palmer | Gene Brabender | | 265 | 156 | 109 |
| 1969-06-08 | vs SE1 | 55 | L 5-7 | 39-16 | 1 | 8,988 | Mike Cuellar | Steve Barber | John O'Donoghue | Mike Cuellar | | 270 | 163 | 107 |
| 1969-06-10 | vs CAL | 56 | W 11-4 | 40-16 | 1 | 8,260 | Tom Phoebus | Rudy May | Marcelino Lopez | Rudy May | | 281 | 167 | 114 |
| 1969-06-11 | vs CAL | 57 | L 5-7 | 40-17 | 1 | 9,817 | Dave McNally | Tom Murphy | Pedro Borbon | Pete Richert | Eddie Fisher | 286 | 174 | 112 |
| 1969-06-13 | @ CHA | 58 | W 5-2 | 41-17 | 1 | 13,793 | Mike Cuellar | Gary Peters | Dave Leonhard | Gary Peters | | 291 | 176 | 115 |
| 1969-06-14 | @ CHA | 59 | W 12-3 | 42-17 | 1 | 6,445 | Jim Palmer | Tommy John | Jim Palmer | Tommy John | Eddie Watt | 303 | 179 | 124 |
| 1969-06-15 | @ CHA | 60 | W 9-0 | 44-17 | 1 | 0 | Dave McNally | Jerry Nyman | Dave McNally | Jerry Nyman | | 312 | 179 | 133 |
| 1969-06-15 | @ CHA | 61 | W 13-2 | 44-17 | 1 | 15,289 | Tom Phoebus | Joe Horlen | Tom Phoebus | Joe Horlen | | 325 | 181 | 144 |
| 1969-06-17 | @ WS2 | 62 | W 5-1 | 45-17 | 1 | 22,134 | Mike Cuellar | Jim Shellenback | Mike Cuellar | Jim Shellenback | | 330 | 182 | 148 |
| 1969-06-18 | @ WS2 | 63 | W 3-1 | 46-17 | 1 | 10,420 | Jim Hardin | Barry Moore | Jim Hardin | Barry Moore | Dick Hall | 333 | 183 | 150 |
| 1969-06-19 | @ WS2 | 64 | W 2-0 | 47-17 | 1 | 13,736 | Dave McNally | Jim Hannan | Dave McNally | Dennis Higgins | | 335 | 183 | 152 |
| 1969-06-20 | @ CLE | 65 | L 2-7 | 48-18 | 1 | 0 | Tom Phoebus | Luis Tiant | Luis Tiant | Tom Phoebus | | 337 | 190 | 147 |
| 1969-06-20 | @ CLE | 66 | W 5-1 | 48-18 | 1 | 14,962 | Marcelino Lopez | Steve Hargan | Marcelino Lopez | Steve Hargan | Eddie Watt | 342 | 191 | 151 |
| 1969-06-21 | @ CLE | 67 | W 3-1 | 49-18 | 1 | 14,503 | Mike Cuellar | Stan Williams | Mike Cuellar | Stan Williams | | 345 | 192 | 153 |
| 1969-06-22 | @ CLE | 68 | L 2-3 | 50-19 | 1 | 0 | Jim Hardin | Sam McDowell | Sam McDowell | Dick Hall | | 347 | 195 | 152 |
| 1969-06-22 | @ CLE | 69 | W 6-0 | 50-19 | 1 | 52,189 | Dave Leonhard | Mike Paul | Dave Leonhard | Horacio Pina | | 353 | 195 | 158 |
| 1969-06-23 | vs WS2 | 70 | W 5-3 | 51-19 | 1 | 7,830 | Dave McNally | Casey Cox | Jim Palmer | Darold Knowles | Pete Richert | 358 | 198 | 160 |
| 1969-06-24 | vs WS2 | 71 | W 6-3 | 52-19 | 1 | 14,763 | Tom Phoebus | Jim Hannan | Dick Hall | Jim Shellenback | | 364 | 201 | 163 |
| 1969-06-25 | vs WS2 | 72 | L 8-11 | 52-20 | 1 | 11,130 | Mike Cuellar | Joe Coleman | Bob Humphreys | Jim Hardin | Darold Knowles | 372 | 212 | 160 |
| 1969-06-27 | vs DET | 73 | W 4-1 | 53-20 | 1 | 39,798 | Dave McNally | Earl Wilson | Dave McNally | Earl Wilson | | 376 | 213 | 163 |
| 1969-06-28 | vs DET | 74 | W 6-4 | 54-20 | 1 | 15,540 | Marcelino Lopez | Denny McLain | Pete Richert | Daryl Patterson | Eddie Watt | 382 | 217 | 165 |
| 1969-06-29 | vs DET | 75 | L 2-3 | 55-21 | 1 | 0 | Mike Cuellar | Mickey Lolich | Mickey Lolich | Mike Cuellar | Mike Kilkenny | 384 | 220 | 164 |
| 1969-06-29 | vs DET | 76 | W 4-3 | 55-21 | 1 | 32,643 | Tom Phoebus | Earl Wilson | Dave Leonhard | Don McMahon | | 388 | 223 | 165 |
| 1969-07-01 | @ NYA | 77 | L 9-10 | 55-22 | 1 | 16,668 | Dave McNally | Stan Bahnsen | Jack Aker | Pete Richert | | 397 | 233 | 164 |
| 1969-07-02 | @ NYA | 78 | L 2-3 | 55-23 | 1 | 14,113 | Marcelino Lopez | Mel Stottlemyre | Mel Stottlemyre | Marcelino Lopez | | 399 | 236 | 163 |
| 1969-07-04 | @ DET | 79 | L 1-4 | 55-24 | 1 | 35,000 | Mike Cuellar | Mickey Lolich | Mickey Lolich | Mike Cuellar | | 400 | 240 | 160 |
| 1969-07-05 | @ DET | 80 | W 9-3 | 56-24 | 1 | 23,627 | Dave McNally | Pat Dobson | Dave McNally | Pat Dobson | | 409 | 243 | 166 |
| 1969-07-06 | @ DET | 81 | L 4-5 | 56-25 | 1 | 33,172 | Jim Hardin | Denny McLain | Denny McLain | Dave Leonhard | | 413 | 248 | 165 |
| 1969-07-08 | vs NYA | 82 | W 10-3 | 58-25 | 1 | 0 | Tom Phoebus | Fritz Peterson | Tom Phoebus | Fritz Peterson | | 423 | 251 | 172 |
| 1969-07-08 | vs NYA | 83 | W 4-1 | 58-25 | 1 | 17,290 | Mike Cuellar | Bill Burbach | Mike Cuellar | Bill Burbach | | 427 | 252 | 175 |
| 1969-07-09 | vs NYA | 84 | W 6-5 | 59-25 | 1 | 19,793 | Dave McNally | Stan Bahnsen | Pete Richert | Ken Johnson | | 433 | 257 | 176 |
| 1969-07-10 | vs BOS | 85 | W 5-4 | 60-25 | 1 | 11,278 | Jim Hardin | Sonny Siebert | Jim Hardin | Vicente Romo | | 438 | 261 | 177 |
| 1969-07-11 | vs BOS | 86 | L 4-7 | 60-27 | 1 | 0 | Marcelino Lopez | Ray Culp | Ray Culp | Al Severinsen | Sparky Lyle | 442 | 268 | 174 |
| 1969-07-11 | vs BOS | 87 | L 3-12 | 60-27 | 1 | 30,844 | Dave Leonhard | Ray Jarvis | Ray Jarvis | Dave Leonhard | Jim Lonborg | 445 | 280 | 165 |
| 1969-07-12 | vs BOS | 88 | W 4-0 | 61-27 | 1 | 36,048 | Mike Cuellar | Mike Nagy | Mike Cuellar | Mike Nagy | | 449 | 280 | 169 |
| 1969-07-13 | vs BOS | 89 | W 6-3 | 62-27 | 1 | 18,868 | Dave McNally | Jim Lonborg | Dave McNally | Jim Lonborg | Eddie Watt | 455 | 283 | 172 |
| 1969-07-15 | vs CLE | 90 | W 5-1 | 63-27 | 1 | 12,027 | Tom Phoebus | Sam McDowell | Tom Phoebus | Sam McDowell | | 460 | 284 | 176 |
| 1969-07-16 | vs CLE | 91 | L 4-6 | 64-28 | 1 | 0 | Mike Cuellar | Dick Ellsworth | Dick Ellsworth | Mike Cuellar | Mike Paul | 464 | 290 | 174 |
| 1969-07-16 | vs CLE | 92 | W 6-5 | 64-28 | 1 | 15,753 | Jim Hardin | Juan Pizarro | Pete Richert | Stan Williams | | 470 | 295 | 175 |
| 1969-07-17 | vs CLE | 93 | W 3-2 | 65-28 | 1 | 9,804 | Dave McNally | Steve Hargan | Pete Richert | Stan Williams | | 473 | 297 | 176 |
| 1969-07-18 | @ BOS | 94 | L 1-6 | 65-29 | 1 | 31,607 | Dave Leonhard | Ray Jarvis | Ray Jarvis | Dave Leonhard | | 474 | 303 | 171 |
| 1969-07-19 | @ BOS | 95 | L 3-5 | 65-30 | 1 | 32,947 | Tom Phoebus | Sonny Siebert | Sonny Siebert | Tom Phoebus | Sparky Lyle | 477 | 308 | 169 |
| 1969-07-20 | @ BOS | 96 | L 5-6 | 65-31 | 1 | 31,174 | Mike Cuellar | Ray Culp | Ray Culp | Mike Cuellar | Sparky Lyle | 482 | 314 | 168 |
| 1969-07-24 | vs CHA | 97 | W 5-2 | 66-31 | 1 | 13,159 | Mike Cuellar | Tommy John | Mike Cuellar | Tommy John | Eddie Watt | 487 | 316 | 171 |
| 1969-07-25 | vs CHA | 98 | W 4-2 | 67-31 | 1 | 11,850 | Dave McNally | Gary Peters | Dave McNally | Gary Peters | Dick Hall | 491 | 318 | 173 |
| 1969-07-26 | vs CHA | 99 | W 2-1 | 68-31 | 1 | 14,091 | Tom Phoebus | Joe Horlen | Tom Phoebus | Joe Horlen | Pete Richert | 493 | 319 | 174 |
| 1969-07-27 | vs CHA | 100 | W 17-0 | 69-31 | 1 | 17,864 | Jim Hardin | Billy Wynne | Jim Hardin | Billy Wynne | | 510 | 319 | 191 |
| 1969-07-29 | @ KCA | 101 | W 4-1 | 70-31 | 1 | 13,478 | Mike Cuellar | Wally Bunker | Mike Cuellar | Wally Bunker | | 514 | 320 | 194 |
| 1969-07-30 | @ KCA | 102 | W 4-2 | 71-31 | 1 | 13,648 | Dave McNally | Roger Nelson | Dave McNally | Roger Nelson | Eddie Watt | 518 | 322 | 196 |
| 1969-07-31 | @ KCA | 103 | W 3-1 | 72-31 | 1 | 12,384 | Tom Phoebus | Jim Rooker | Tom Phoebus | Jim Rooker | Dick Hall | 521 | 323 | 198 |
| 1969-08-01 | @ MIN | 104 | L 3-4 | 72-32 | 1 | 35,725 | Jim Hardin | Dean Chance | Ron Perranoski | Dave Leonhard | | 524 | 327 | 197 |
| 1969-08-02 | @ MIN | 105 | W 6-5 | 73-32 | 1 | 36,152 | Mike Cuellar | Jim Perry | Mike Cuellar | Al Worthington | Pete Richert | 530 | 332 | 198 |
| 1969-08-03 | @ MIN | 106 | L 2-5 | 73-33 | 1 | 40,661 | Dave McNally | Jim Kaat | Jim Kaat | Dave McNally | Al Worthington | 532 | 337 | 195 |
| 1969-08-04 | @ CLE | 107 | L 0-2 | 73-34 | 1 | 5,034 | Tom Phoebus | Steve Hargan | Steve Hargan | Tom Phoebus | | 532 | 339 | 193 |
| 1969-08-05 | vs KCA | 108 | W 7-5 | 74-34 | 1 | 25,980 | Jim Hardin | Roger Nelson | Eddie Watt | Galen Cisco | | 539 | 344 | 195 |
| 1969-08-06 | vs KCA | 109 | W 2-1 | 75-34 | 1 | 9,927 | Mike Cuellar | Jim Rooker | Mike Cuellar | Jim Rooker | Pete Richert | 541 | 345 | 196 |
| 1969-08-07 | vs KCA | 110 | W 10-2 | 76-34 | 1 | 9,415 | Dave McNally | Dick Drago | Dave McNally | Dick Drago | | 551 | 347 | 204 |
| 1969-08-08 | vs MIN | 111 | W 6-5 | 77-34 | 1 | 20,487 | Tom Phoebus | Bob Miller | Marcelino Lopez | Ron Perranoski | | 557 | 352 | 205 |
| 1969-08-09 | vs MIN | 112 | W 5-1 | 78-34 | 1 | 26,873 | Jim Palmer | Dean Chance | Jim Palmer | Dean Chance | Pete Richert | 562 | 353 | 209 |
| 1969-08-10 | vs MIN | 113 | W 2-0 | 79-34 | 1 | 22,263 | Mike Cuellar | Jim Perry | Mike Cuellar | Jim Perry | | 564 | 353 | 211 |
| 1969-08-11 | vs OAK | 114 | L 4-7 | 79-35 | 1 | 14,785 | Dave McNally | Blue Moon Odom | Jim Nash | Dave McNally | Rollie Fingers | 568 | 360 | 208 |
| 1969-08-12 | vs OAK | 115 | W 4-3 | 80-35 | 1 | 19,106 | Tom Phoebus | Catfish Hunter | Pete Richert | Paul Lindblad | | 572 | 363 | 209 |
| 1969-08-13 | vs OAK | 116 | W 8-0 | 81-35 | 1 | 16,826 | Jim Palmer | Chuck Dobson | Jim Palmer | Chuck Dobson | | 580 | 363 | 217 |
| 1969-08-15 | @ SE1 | 117 | W 2-1 | 82-35 | 1 | 9,922 | Mike Cuellar | Gene Brabender | Mike Cuellar | Gene Brabender | | 582 | 364 | 218 |
| 1969-08-16 | @ SE1 | 118 | W 15-3 | 83-35 | 1 | 11,550 | Dave McNally | Diego Segui | Dave McNally | Diego Segui | Jim Hardin | 597 | 367 | 230 |
| 1969-08-17 | @ SE1 | 119 | W 4-1 | 84-35 | 1 | 10,227 | Tom Phoebus | Fred Talbot | Tom Phoebus | Fred Talbot | Eddie Watt | 601 | 368 | 233 |
| 1969-08-18 | @ SE1 | 120 | W 12-3 | 85-35 | 1 | 19,770 | Jim Palmer | George Brunet | Jim Palmer | George Brunet | | 613 | 371 | 242 |
| 1969-08-19 | @ CAL | 121 | W 10-0 | 86-35 | 1 | 9,887 | Mike Cuellar | Rudy May | Mike Cuellar | Rudy May | | 623 | 371 | 252 |
| 1969-08-20 | @ CAL | 122 | L 2-3 | 86-36 | 1 | 11,334 | Dave McNally | Andy Messersmith | Andy Messersmith | Dave McNally | Ken Tatum | 625 | 374 | 251 |
| 1969-08-21 | @ CAL | 123 | L 0-2 | 86-37 | 1 | 10,658 | Tom Phoebus | Steve Kealey | Steve Kealey | Tom Phoebus | | 625 | 376 | 249 |
| 1969-08-22 | @ OAK | 124 | W 4-3 | 87-37 | 1 | 14,609 | Jim Palmer | Lew Krausse | Jim Palmer | Paul Lindblad | Eddie Watt | 629 | 379 | 250 |
| 1969-08-23 | @ OAK | 125 | L 2-4 | 87-38 | 1 | 12,881 | Mike Cuellar | Catfish Hunter | Paul Lindblad | Mike Cuellar | Vida Blue | 631 | 383 | 248 |
| 1969-08-24 | @ OAK | 126 | L 0-9 | 87-40 | 1 | 0 | Dave McNally | Chuck Dobson | Chuck Dobson | Dave McNally | | 631 | 392 | 239 |
| 1969-08-24 | @ OAK | 127 | L 8-9 | 87-40 | 1 | 24,970 | Jim Hardin | Blue Moon Odom | Jim Nash | Marcelino Lopez | | 639 | 401 | 238 |
| 1969-08-26 | vs SE1 | 128 | L 1-2 | 87-41 | 1 | 11,400 | Tom Phoebus | Gene Brabender | Gene Brabender | Tom Phoebus | | 640 | 403 | 237 |
| 1969-08-27 | vs SE1 | 129 | W 7-2 | 88-41 | 1 | 8,960 | Mike Cuellar | George Brunet | Mike Cuellar | George Brunet | | 647 | 405 | 242 |
| 1969-08-28 | vs SE1 | 130 | W 4-3 | 89-41 | 1 | 8,118 | Jim Palmer | Fred Talbot | Eddie Watt | Dooley Womack | | 651 | 408 | 243 |
| 1969-08-29 | vs CAL | 131 | L 2-6 | 89-43 | 1 | 0 | Dave McNally | Andy Messersmith | Andy Messersmith | Dave McNally | Ken Tatum | 653 | 414 | 239 |
| 1969-08-29 | vs CAL | 132 | L 1-2 | 89-43 | 1 | 13,350 | Jim Hardin | Jim McGlothlin | Jim McGlothlin | Jim Hardin | | 654 | 416 | 238 |
| 1969-08-30 | vs CAL | 133 | W 6-3 | 90-43 | 1 | 10,189 | Tom Phoebus | Steve Kealey | Dave Leonhard | Clyde Wright | | 660 | 419 | 241 |
| 1969-08-31 | vs CAL | 134 | W 5-4 | 91-43 | 1 | 11,255 | Mike Cuellar | Rudy May | Mike Cuellar | Rudy May | Dick Hall | 665 | 423 | 242 |
| 1969-09-01 | @ CHA | 135 | W 8-0 | 92-43 | 1 | 18,102 | Jim Palmer | Billy Wynne | Jim Palmer | Billy Wynne | | 673 | 423 | 250 |
| 1969-09-02 | @ CHA | 136 | L 3-10 | 92-44 | 1 | 5,336 | Dave McNally | Gary Peters | Gary Peters | Dave McNally | Wilbur Wood | 676 | 433 | 243 |
| 1969-09-04 | @ DET | 137 | W 5-4 | 93-44 | 1 | 13,799 | Tom Phoebus | Earl Wilson | Pete Richert | Tom Timmermann | | 681 | 437 | 244 |
| 1969-09-05 | @ DET | 138 | W 8-4 | 94-44 | 1 | 32,090 | Mike Cuellar | Mike Kilkenny | Mike Cuellar | Mike Kilkenny | | 689 | 441 | 248 |
| 1969-09-06 | @ DET | 139 | L 4-5 | 94-45 | 1 | 18,451 | Jim Palmer | Mickey Lolich | Tom Timmermann | Eddie Watt | | 693 | 446 | 247 |
| 1969-09-07 | @ DET | 140 | W 6-5 | 95-45 | 1 | 29,771 | Dave McNally | Denny McLain | Eddie Watt | Pat Dobson | | 699 | 451 | 248 |
| 1969-09-09 | vs WS2 | 141 | W 6-1 | 97-45 | 1 | 0 | Mike Cuellar | Cisco Carlos | Mike Cuellar | Cisco Carlos | | 705 | 452 | 253 |
| 1969-09-09 | vs WS2 | 142 | W 3-2 | 97-45 | 1 | 10,747 | Tom Phoebus | Joe Coleman | Tom Phoebus | Joe Coleman | Eddie Watt | 708 | 454 | 254 |
| 1969-09-10 | vs BOS | 143 | W 8-7 | 98-45 | 1 | 10,553 | Jim Palmer | Mike Nagy | Al Severinsen | Gary Wagner | Eddie Watt | 716 | 461 | 255 |
| 1969-09-11 | vs BOS | 144 | W 4-2 | 99-45 | 1 | 7,284 | Dave McNally | Lee Stange | Dave McNally | Lee Stange | | 720 | 463 | 257 |
| 1969-09-12 | vs CLE | 145 | W 2-1 | 100-45 | 1 | 9,454 | Jim Hardin | Mike Paul | Jim Hardin | Stan Williams | Pete Richert | 722 | 464 | 258 |
| 1969-09-13 | vs CLE | 146 | W 10-5 | 101-45 | 1 | 20,075 | Tom Phoebus | Steve Hargan | Tom Phoebus | Steve Hargan | Dave Leonhard | 732 | 469 | 263 |
| 1969-09-14 | vs CLE | 147 | W 7-3 | 102-45 | 1 | 9,434 | Mike Cuellar | Sam McDowell | Mike Cuellar | Sam McDowell | | 739 | 472 | 267 |
| 1969-09-15 | @ WS2 | 148 | L 2-3 | 102-46 | 1 | 5,376 | Jim Palmer | Dick Bosman | Bob Humphreys | Jim Palmer | | 741 | 475 | 266 |
| 1969-09-16 | @ WS2 | 149 | W 1-0 | 103-46 | 1 | 8,165 | Dave McNally | Jim Hannan | Dave McNally | Jim Hannan | Eddie Watt | 742 | 475 | 267 |
| 1969-09-18 | @ BOS | 150 | W 6-4 | 104-47 | 1 | 0 | Mike Cuellar | Mike Nagy | Mike Cuellar | Gary Wagner | Dick Hall | 748 | 479 | 269 |
| 1969-09-18 | @ BOS | 151 | L 0-5 | 104-47 | 1 | 20,430 | Jim Hardin | Vicente Romo | Vicente Romo | Jim Hardin | | 748 | 484 | 264 |
| 1969-09-19 | vs NYA | 152 | W 4-2 | 105-47 | 1 | 9,223 | Jim Palmer | Mike Kekich | Jim Palmer | Mike Kekich | | 752 | 486 | 266 |
| 1969-09-20 | vs NYA | 153 | W 8-7 | 106-47 | 1 | 7,115 | Dave McNally | Al Downing | Marcelino Lopez | Jack Aker | Pete Richert | 760 | 493 | 267 |
| 1969-09-23 | @ CLE | 154 | L 1-3 | 106-48 | 1 | 3,273 | Tom Phoebus | Sam McDowell | Sam McDowell | Tom Phoebus | | 761 | 496 | 265 |
| 1969-09-24 | @ CLE | 155 | W 4-3 | 107-48 | 1 | 3,297 | Mike Cuellar | Steve Hargan | Dick Hall | Ron Law | | 765 | 499 | 266 |
| 1969-09-25 | @ CLE | 156 | W 4-1 | 108-48 | 1 | 3,620 | Dave McNally | Luis Tiant | Dave McNally | Luis Tiant | | 769 | 500 | 269 |
| 1969-09-26 | @ NYA | 157 | L 2-4 | 108-49 | 1 | 7,749 | Jim Palmer | Mike Kekich | Mike Kekich | Jim Palmer | | 771 | 504 | 267 |
| 1969-09-27 | @ NYA | 158 | L 0-1 | 108-50 | 1 | 12,000 | Jim Hardin | Fritz Peterson | Fritz Peterson | Jim Hardin | | 771 | 505 | 266 |
| 1969-09-28 | @ NYA | 159 | L 2-3 | 108-51 | 1 | 10,097 | Tom Phoebus | Mel Stottlemyre | Mel Stottlemyre | Pete Richert | | 773 | 508 | 265 |
| 1969-09-29 | vs DET | 160 | L 1-4 | 108-52 | 1 | 6,252 | Mike Cuellar | Mike Kilkenny | Mike Kilkenny | Mike Cuellar | | 774 | 512 | 262 |
| 1969-09-30 | vs DET | 161 | L 3-4 | 108-53 | 1 | 4,877 | Dave McNally | Tom Timmermann | Tom Timmermann | Dave McNally | | 777 | 516 | 261 |
| 1969-10-01 | vs DET | 162 | W 2-1 | 109-53 | 1 | 4,222 | Jim Palmer | Mickey Lolich | Jim Palmer | Mickey Lolich | | 779 | 517 | 262 |