| 1968-04-10 | vs ATL | 1 | W 2-1 | 1-0 | 1 | 34,740 | Bob Gibson | Pat Jarvis | Ray Washburn | Pat Jarvis | | 2 | 1 | 1 |
| 1968-04-11 | vs ATL | 2 | W 10-3 | 2-0 | 1 | 16,214 | Nelson Briles | Dick Kelley | Nelson Briles | Dick Kelley | Joe Hoerner | 12 | 4 | 8 |
| 1968-04-13 | @ CHN | 3 | W 8-5 | 3-0 | 1 | 33,875 | Steve Carlton | Rich Nye | Steve Carlton | Bill Hands | Ron Willis | 20 | 9 | 11 |
| 1968-04-14 | @ CHN | 4 | L 6-7 | 3-1 | 2 | 8,343 | Dick Hughes | Joe Niekro | Joe Niekro | Dick Hughes | Bobby Tiefenauer | 26 | 16 | 10 |
| 1968-04-15 | @ ATL | 5 | W 4-3 | 4-1 | 2 | 11,738 | Bob Gibson | Pat Jarvis | Joe Hoerner | Pat Jarvis | Dick Hughes | 30 | 19 | 11 |
| 1968-04-16 | @ ATL | 6 | W 6-2 | 5-1 | 1 | 8,412 | Nelson Briles | Tony Cloninger | Nelson Briles | Tony Cloninger | Joe Hoerner | 36 | 21 | 15 |
| 1968-04-17 | @ CIN | 7 | L 3-4 | 5-2 | 1 | 3,374 | Steve Carlton | Milt Pappas | Bob Lee | Ron Willis | | 39 | 25 | 14 |
| 1968-04-18 | @ CIN | 8 | L 3-4 | 5-3 | 3 | 6,728 | Ray Washburn | George Culver | Bob Lee | Larry Jaster | | 42 | 29 | 13 |
| 1968-04-19 | vs CHN | 9 | W 9-2 | 6-3 | 1 | 13,129 | Mike Torrez | Rich Nye | Mike Torrez | Rich Nye | Hal Gilson | 51 | 31 | 20 |
| 1968-04-20 | vs CHN | 10 | L 1-5 | 6-4 | 2 | 29,348 | Bob Gibson | Fergie Jenkins | Fergie Jenkins | Bob Gibson | | 52 | 36 | 16 |
| 1968-04-21 | vs CHN | 11 | W 9-2 | 7-4 | 1 | 26,942 | Nelson Briles | Ken Holtzman | Nelson Briles | Ken Holtzman | | 61 | 38 | 23 |
| 1968-04-23 | vs CIN | 12 | W 4-2 | 8-4 | 1 | 8,706 | Steve Carlton | George Culver | Joe Hoerner | Billy McCool | | 65 | 40 | 25 |
| 1968-04-24 | vs CIN | 13 | W 7-0 | 9-4 | 1 | 9,666 | Ray Washburn | John Tsitouris | Ray Washburn | John Tsitouris | | 72 | 40 | 32 |
| 1968-04-26 | vs PIT | 14 | W 2-1 | 10-4 | 1 | 39,866 | Bob Gibson | Bob Veale | Bob Gibson | Bob Veale | | 74 | 41 | 33 |
| 1968-04-27 | vs PIT | 15 | W 7-5 | 11-4 | 1 | 20,863 | Nelson Briles | Al McBean | Nelson Briles | Al McBean | Joe Hoerner | 81 | 46 | 35 |
| 1968-04-28 | vs PIT | 16 | W 4-2 | 12-4 | 1 | 20,562 | Steve Carlton | Tommie Sisk | Steve Carlton | Tommie Sisk | | 85 | 48 | 37 |
| 1968-04-29 | @ LAN | 17 | L 2-3 | 12-5 | 1 | 21,562 | Mike Torrez | Don Sutton | Don Sutton | Mike Torrez | Jim Brewer | 87 | 51 | 36 |
| 1968-04-30 | @ LAN | 18 | W 2-1 | 13-5 | 1 | 20,901 | Ray Washburn | Bill Singer | Ray Washburn | Bill Singer | Joe Hoerner | 89 | 52 | 37 |
| 1968-05-01 | @ HOU | 19 | W 3-1 | 14-5 | 1 | 14,726 | Bob Gibson | Dave Giusti | Bob Gibson | Wade Blasingame | | 92 | 53 | 39 |
| 1968-05-02 | @ HOU | 20 | L 0-4 | 14-6 | 1 | 11,431 | Nelson Briles | Denny Lemaster | Denny Lemaster | Nelson Briles | | 92 | 57 | 35 |
| 1968-05-03 | @ SFN | 21 | L 4-5 | 14-7 | 1 | 15,935 | Steve Carlton | Juan Marichal | Juan Marichal | Steve Carlton | | 96 | 62 | 34 |
| 1968-05-04 | @ SFN | 22 | W 11-6 | 15-7 | 1 | 17,485 | Dick Hughes | Ray Sadecki | Mike Torrez | Ray Sadecki | Joe Hoerner | 107 | 68 | 39 |
| 1968-05-05 | @ SFN | 23 | L 4-8 | 15-8 | 1 | 28,007 | Ray Washburn | Mike McCormick | Mike McCormick | Ray Washburn | | 111 | 76 | 35 |
| 1968-05-06 | vs NYN | 24 | W 2-1 | 16-8 | 1 | 12,741 | Bob Gibson | Tom Seaver | Bob Gibson | Tom Seaver | | 113 | 77 | 36 |
| 1968-05-07 | vs NYN | 25 | L 1-4 | 16-9 | 1 | 9,687 | Nelson Briles | Nolan Ryan | Nolan Ryan | Nelson Briles | | 114 | 81 | 33 |
| 1968-05-08 | vs NYN | 26 | W 2-0 | 17-9 | 1 | 11,282 | Steve Carlton | Al Jackson | Steve Carlton | Al Jackson | | 116 | 81 | 35 |
| 1968-05-11 | vs HOU | 27 | W 4-3 | 18-9 | 1 | 16,093 | Ray Washburn | Denny Lemaster | Larry Jaster | Mike Cuellar | | 120 | 84 | 36 |
| 1968-05-12 | vs HOU | 28 | L 2-3 | 18-10 | 1 | 19,085 | Bob Gibson | Larry Dierker | Larry Dierker | Bob Gibson | | 122 | 87 | 35 |
| 1968-05-13 | @ PIT | 29 | W 1-0 | 19-10 | 1 | 10,082 | Nelson Briles | Jim Bunning | Nelson Briles | Jim Bunning | | 123 | 87 | 36 |
| 1968-05-15 | @ PIT | 30 | W 1-0 | 20-10 | 1 | 9,461 | Steve Carlton | Steve Blass | Steve Carlton | Steve Blass | | 124 | 87 | 37 |
| 1968-05-16 | @ PIT | 31 | L 0-3 | 20-11 | 1 | 9,595 | Ray Washburn | Bob Veale | Bob Veale | Ray Washburn | | 124 | 90 | 34 |
| 1968-05-17 | @ PHI | 32 | L 0-1 | 20-12 | 1 | 17,034 | Bob Gibson | Woodie Fryman | Woodie Fryman | Bob Gibson | | 124 | 91 | 33 |
| 1968-05-18 | @ PHI | 33 | L 2-3 | 20-13 | 1 | 12,941 | Nelson Briles | Larry Jackson | Larry Jackson | Nelson Briles | | 126 | 94 | 32 |
| 1968-05-19 | @ PHI | 34 | L 3-4 | 20-14 | 1 | 27,725 | Steve Carlton | Chris Short | Turk Farrell | Joe Hoerner | | 129 | 98 | 31 |
| 1968-05-20 | vs LAN | 35 | W 2-1 | 21-14 | 1 | 12,764 | Larry Jaster | Don Sutton | Larry Jaster | Don Sutton | | 131 | 99 | 32 |
| 1968-05-21 | vs LAN | 36 | L 2-9 | 21-15 | 1 | 13,633 | Ray Washburn | Bill Singer | Bill Singer | Ray Washburn | | 133 | 108 | 25 |
| 1968-05-22 | vs LAN | 37 | L 0-2 | 21-16 | 1 | 9,560 | Bob Gibson | Don Drysdale | Don Drysdale | Bob Gibson | | 133 | 110 | 23 |
| 1968-05-23 | vs LAN | 38 | L 2-3 | 21-17 | 2 | 11,065 | Nelson Briles | Claude Osteen | John Purdin | Dick Hughes | | 135 | 113 | 22 |
| 1968-05-24 | vs PHI | 39 | W 5-1 | 22-17 | 2 | 34,515 | Steve Carlton | Chris Short | Steve Carlton | Chris Short | | 140 | 114 | 26 |
| 1968-05-25 | vs PHI | 40 | L 0-1 | 22-18 | 2 | 19,432 | Larry Jaster | Larry Jackson | Larry Jackson | Larry Jaster | Turk Farrell | 140 | 115 | 25 |
| 1968-05-26 | vs PHI | 41 | L 3-9 | 22-19 | 2 | 42,446 | Ray Washburn | Woodie Fryman | Woodie Fryman | Hal Gilson | | 143 | 124 | 19 |
| 1968-05-28 | vs SFN | 42 | L 1-3 | 22-20 | 4 | 19,392 | Bob Gibson | Gaylord Perry | Gaylord Perry | Bob Gibson | | 144 | 127 | 17 |
| 1968-05-29 | vs SFN | 43 | L 1-2 | 22-21 | 4 | 25,412 | Nelson Briles | Juan Marichal | Juan Marichal | Nelson Briles | | 145 | 129 | 16 |
| 1968-05-30 | vs SFN | 44 | W 6-0 | 23-21 | 3 | 23,246 | Steve Carlton | Ray Sadecki | Steve Carlton | Ray Sadecki | | 151 | 129 | 22 |
| 1968-05-31 | @ NYN | 45 | W 2-0 | 24-21 | 2 | 41,075 | Larry Jaster | Tom Seaver | Larry Jaster | Tom Seaver | | 153 | 129 | 24 |
| 1968-06-01 | @ NYN | 46 | W 6-5 | 25-21 | 1 | 28,006 | Ray Washburn | Nolan Ryan | Joe Hoerner | Cal Koonce | | 159 | 134 | 25 |
| 1968-06-02 | @ NYN | 47 | W 6-3 | 27-21 | 1 | 0 | Bob Gibson | Al Jackson | Bob Gibson | Al Jackson | | 165 | 137 | 28 |
| 1968-06-02 | @ NYN | 48 | W 3-2 | 27-21 | 1 | 32,520 | Dick Hughes | Don Cardwell | Dick Hughes | Don Cardwell | Ron Willis | 168 | 139 | 29 |
| 1968-06-03 | @ HOU | 49 | W 7-2 | 28-21 | 1 | 17,970 | Nelson Briles | Denny Lemaster | Nelson Briles | Denny Lemaster | | 175 | 141 | 34 |
| 1968-06-04 | @ HOU | 50 | W 3-2 | 29-21 | 1 | 18,867 | Steve Carlton | Mike Cuellar | Steve Carlton | John Buzhardt | Joe Hoerner | 178 | 143 | 35 |
| 1968-06-05 | @ HOU | 51 | W 3-1 | 30-21 | 1 | 18,475 | Larry Jaster | Larry Dierker | Larry Jaster | Larry Dierker | Wayne Granger | 181 | 144 | 37 |
| 1968-06-06 | @ HOU | 52 | W 4-0 | 31-21 | 1 | 15,218 | Bob Gibson | Don Wilson | Bob Gibson | Don Wilson | | 185 | 144 | 41 |
| 1968-06-07 | @ CIN | 53 | L 2-4 | 31-22 | 1 | 17,685 | Dick Hughes | Jim Maloney | Jim Maloney | Hal Gilson | | 187 | 148 | 39 |
| 1968-06-08 | @ CIN | 54 | W 7-2 | 32-22 | 1 | 13,368 | Nelson Briles | George Culver | Nelson Briles | George Culver | | 194 | 150 | 44 |
| 1968-06-09 | @ CIN | 55 | W 10-8 | 33-23 | 1 | 0 | Steve Carlton | Gerry Arrigo | Ron Willis | Bob Lee | | 204 | 158 | 46 |
| 1968-06-09 | @ CIN | 56 | L 6-7 | 33-23 | 1 | 28,141 | Ray Washburn | Billy McCool | George Culver | Steve Carlton | | 210 | 165 | 45 |
| 1968-06-10 | @ ATL | 57 | W 4-3 | 34-23 | 1 | 26,836 | Larry Jaster | Phil Niekro | Larry Jaster | Phil Niekro | Wayne Granger | 214 | 168 | 46 |
| 1968-06-11 | @ ATL | 58 | W 6-0 | 35-23 | 1 | 23,345 | Bob Gibson | Dick Kelley | Bob Gibson | Dick Kelley | | 220 | 168 | 52 |
| 1968-06-12 | @ ATL | 59 | L 1-7 | 35-24 | 1 | 16,656 | Nelson Briles | Pat Jarvis | Pat Jarvis | Nelson Briles | | 221 | 175 | 46 |
| 1968-06-13 | @ ATL | 60 | W 3-1 | 36-24 | 1 | 20,254 | Steve Carlton | Ken Johnson | Joe Hoerner | Phil Niekro | Hal Gilson | 224 | 176 | 48 |
| 1968-06-14 | vs CIN | 61 | L 0-7 | 36-25 | 1 | 31,507 | Larry Jaster | Billy McCool | Billy McCool | Larry Jaster | Ted Abernathy | 224 | 183 | 41 |
| 1968-06-15 | vs CIN | 62 | W 2-0 | 37-25 | 1 | 35,831 | Bob Gibson | Gary Nolan | Bob Gibson | Gary Nolan | | 226 | 183 | 43 |
| 1968-06-16 | vs CIN | 63 | W 4-2 | 38-25 | 1 | 31,737 | Ray Washburn | George Culver | Ray Washburn | George Culver | Ron Willis | 230 | 185 | 45 |
| 1968-06-18 | vs CHN | 64 | W 1-0 | 39-25 | 1 | 28,235 | Nelson Briles | Bill Hands | Nelson Briles | Bill Hands | | 231 | 185 | 46 |
| 1968-06-19 | vs CHN | 65 | W 4-0 | 40-25 | 1 | 27,577 | Steve Carlton | Rich Nye | Steve Carlton | Rich Nye | | 235 | 185 | 50 |
| 1968-06-20 | vs CHN | 66 | W 1-0 | 41-25 | 1 | 26,550 | Bob Gibson | Fergie Jenkins | Bob Gibson | Fergie Jenkins | | 236 | 185 | 51 |
| 1968-06-21 | vs ATL | 67 | W 4-3 | 42-25 | 1 | 37,869 | Larry Jaster | Phil Niekro | Wayne Granger | Claude Raymond | | 240 | 188 | 52 |
| 1968-06-22 | vs ATL | 68 | W 6-1 | 43-25 | 1 | 24,608 | Ray Washburn | Pat Jarvis | Ray Washburn | Pat Jarvis | | 246 | 189 | 57 |
| 1968-06-23 | vs ATL | 69 | L 1-5 | 44-26 | 1 | 0 | Nelson Briles | Dick Kelley | Cecil Upshaw | Nelson Briles | | 247 | 194 | 53 |
| 1968-06-23 | vs ATL | 70 | W 3-1 | 44-26 | 1 | 49,743 | Mel Nelson | Ken Johnson | Mel Nelson | Ken Johnson | | 250 | 195 | 55 |
| 1968-06-25 | vs PIT | 71 | L 2-3 | 44-27 | 1 | 26,927 | Steve Carlton | Bob Veale | Bob Veale | Steve Carlton | Luke Walker | 252 | 198 | 54 |
| 1968-06-26 | vs PIT | 72 | W 3-0 | 45-28 | 1 | 0 | Bob Gibson | Al McBean | Bob Gibson | Al McBean | | 255 | 198 | 57 |
| 1968-06-26 | vs PIT | 73 | L 1-3 | 45-28 | 1 | 30,641 | Larry Jaster | Steve Blass | Steve Blass | Larry Jaster | Ron Kline | 256 | 201 | 55 |
| 1968-06-28 | @ CHN | 74 | W 9-5 | 46-28 | 1 | 17,433 | Nelson Briles | Fergie Jenkins | Nelson Briles | Fergie Jenkins | Wayne Granger | 265 | 206 | 59 |
| 1968-06-29 | @ CHN | 75 | L 8-10 | 46-29 | 1 | 18,872 | Ray Washburn | Joe Niekro | Phil Regan | Mel Nelson | | 273 | 216 | 57 |
| 1968-06-30 | @ CHN | 76 | L 2-6 | 46-30 | 1 | 36,414 | Steve Carlton | Bill Hands | Bill Hands | Steve Carlton | | 275 | 222 | 53 |
| 1968-07-01 | @ LAN | 77 | W 5-1 | 47-30 | 1 | 42,603 | Bob Gibson | Don Drysdale | Bob Gibson | Don Drysdale | | 280 | 223 | 57 |
| 1968-07-02 | @ LAN | 78 | W 5-3 | 48-30 | 1 | 22,828 | Larry Jaster | Bill Singer | Wayne Granger | Jim Brewer | Joe Hoerner | 285 | 226 | 59 |
| 1968-07-03 | @ LAN | 79 | W 2-1 | 49-30 | 1 | 24,178 | Nelson Briles | Mike Kekich | Nelson Briles | Mike Kekich | | 287 | 227 | 60 |
| 1968-07-04 | @ LAN | 80 | W 3-2 | 50-30 | 1 | 21,681 | Ray Washburn | Claude Osteen | Ray Washburn | Claude Osteen | Dick Hughes | 290 | 229 | 61 |
| 1968-07-05 | @ SFN | 81 | W 4-3 | 51-30 | 1 | 15,556 | Steve Carlton | Mike McCormick | Wayne Granger | Joe Gibbon | | 294 | 232 | 62 |
| 1968-07-06 | @ SFN | 82 | W 3-0 | 52-30 | 1 | 28,233 | Bob Gibson | Juan Marichal | Bob Gibson | Juan Marichal | | 297 | 232 | 65 |
| 1968-07-07 | @ SFN | 83 | W 2-0 | 53-30 | 1 | 23,993 | Larry Jaster | Gaylord Perry | Larry Jaster | Gaylord Perry | Ron Willis | 299 | 232 | 67 |
| 1968-07-11 | vs HOU | 84 | L 4-5 | 54-31 | 1 | 0 | Nelson Briles | Larry Dierker | John Buzhardt | Ron Willis | Tom Dukes | 303 | 237 | 66 |
| 1968-07-11 | vs HOU | 85 | W 8-7 | 54-31 | 1 | 35,300 | Mel Nelson | Mike Cuellar | Ron Willis | Tom Dukes | Joe Hoerner | 311 | 244 | 67 |
| 1968-07-12 | vs HOU | 86 | W 8-1 | 55-31 | 1 | 28,944 | Bob Gibson | Denny Lemaster | Bob Gibson | Denny Lemaster | | 319 | 245 | 74 |
| 1968-07-13 | vs HOU | 87 | W 5-4 | 56-31 | 1 | 37,139 | Steve Carlton | Wade Blasingame | Steve Carlton | Danny Coombs | Joe Hoerner | 324 | 249 | 75 |
| 1968-07-14 | vs LAN | 88 | W 5-1 | 57-31 | 1 | 34,761 | Larry Jaster | Mike Kekich | Larry Jaster | Mike Kekich | Joe Hoerner | 329 | 250 | 79 |
| 1968-07-15 | vs LAN | 89 | W 4-2 | 58-31 | 1 | 24,081 | Ray Washburn | Claude Osteen | Ray Washburn | Claude Osteen | Mel Nelson | 333 | 252 | 81 |
| 1968-07-16 | vs SFN | 90 | W 6-1 | 59-31 | 1 | 27,249 | Nelson Briles | Ray Sadecki | Nelson Briles | Ray Sadecki | | 339 | 253 | 86 |
| 1968-07-18 | vs SFN | 91 | L 0-3 | 59-32 | 1 | 29,359 | Steve Carlton | Juan Marichal | Juan Marichal | Steve Carlton | | 339 | 256 | 83 |
| 1968-07-19 | vs NYN | 92 | L 2-4 | 59-33 | 1 | 40,510 | Larry Jaster | Al Jackson | Al Jackson | Larry Jaster | Ron Taylor | 341 | 260 | 81 |
| 1968-07-20 | vs NYN | 93 | W 2-0 | 60-33 | 1 | 22,794 | Ray Washburn | Dick Selma | Ray Washburn | Dick Selma | | 343 | 260 | 83 |
| 1968-07-21 | vs NYN | 94 | W 2-0 | 61-34 | 1 | 0 | Bob Gibson | Jim McAndrew | Bob Gibson | Jim McAndrew | | 345 | 260 | 85 |
| 1968-07-21 | vs NYN | 95 | L 0-1 | 61-34 | 1 | 45,408 | Nelson Briles | Jerry Koosman | Jerry Koosman | Nelson Briles | | 345 | 261 | 84 |
| 1968-07-22 | vs PHI | 96 | W 5-4 | 62-34 | 1 | 17,619 | Steve Carlton | Woodie Fryman | Wayne Granger | John Boozer | | 350 | 265 | 85 |
| 1968-07-23 | vs PHI | 97 | W 11-5 | 63-34 | 1 | 26,199 | Larry Jaster | Rick Wise | Larry Jaster | Rick Wise | Dick Hughes | 361 | 270 | 91 |
| 1968-07-24 | vs PHI | 98 | W 3-1 | 64-34 | 1 | 23,828 | Ray Washburn | Larry Jackson | Ray Washburn | Larry Jackson | Joe Hoerner | 364 | 271 | 93 |
| 1968-07-25 | vs PHI | 99 | W 5-0 | 65-34 | 1 | 28,147 | Bob Gibson | Chris Short | Bob Gibson | Chris Short | | 369 | 271 | 98 |
| 1968-07-26 | @ PIT | 100 | W 9-1 | 66-35 | 1 | 0 | Nelson Briles | Steve Blass | Nelson Briles | Steve Blass | | 378 | 272 | 106 |
| 1968-07-26 | @ PIT | 101 | L 4-5 | 66-35 | 1 | 23,515 | Mel Nelson | Jim Bunning | Ron Kline | Wayne Granger | | 382 | 277 | 105 |
| 1968-07-27 | @ PIT | 102 | W 4-0 | 67-35 | 1 | 12,147 | Steve Carlton | Bob Moose | Steve Carlton | Bob Moose | | 386 | 277 | 109 |
| 1968-07-28 | @ PIT | 103 | L 1-7 | 67-36 | 1 | 14,926 | Larry Jaster | Al McBean | Al McBean | Larry Jaster | | 387 | 284 | 103 |
| 1968-07-29 | @ NYN | 104 | W 5-1 | 68-36 | 1 | 30,486 | Ray Washburn | Nolan Ryan | Ray Washburn | Nolan Ryan | | 392 | 285 | 107 |
| 1968-07-30 | @ NYN | 105 | W 7-1 | 69-36 | 1 | 34,835 | Bob Gibson | Dick Selma | Bob Gibson | Dick Selma | | 399 | 286 | 113 |
| 1968-07-31 | @ PHI | 106 | W 3-2 | 70-36 | 1 | 14,811 | Nelson Briles | Woodie Fryman | Nelson Briles | Woodie Fryman | | 402 | 288 | 114 |
| 1968-08-01 | @ PHI | 107 | W 2-1 | 71-36 | 1 | 12,674 | Steve Carlton | Larry Jackson | Steve Carlton | Larry Jackson | | 404 | 289 | 115 |
| 1968-08-02 | vs CHN | 108 | L 0-3 | 71-37 | 1 | 39,621 | Larry Jaster | Ken Holtzman | Ken Holtzman | Larry Jaster | | 404 | 292 | 112 |
| 1968-08-03 | vs CHN | 109 | L 2-3 | 71-38 | 1 | 38,264 | Ray Washburn | Bill Hands | Bill Hands | Ray Washburn | Phil Regan | 406 | 295 | 111 |
| 1968-08-04 | vs CHN | 110 | L 5-6 | 71-39 | 1 | 47,445 | Bob Gibson | Fergie Jenkins | Jack Lamabe | Joe Hoerner | Joe Niekro | 411 | 301 | 110 |
| 1968-08-05 | vs CIN | 111 | W 3-2 | 72-39 | 1 | 26,607 | Nelson Briles | Gerry Arrigo | Nelson Briles | Gerry Arrigo | Joe Hoerner | 414 | 303 | 111 |
| 1968-08-06 | vs CIN | 112 | L 0-5 | 72-40 | 1 | 26,299 | Steve Carlton | Jim Maloney | Jim Maloney | Steve Carlton | | 414 | 308 | 106 |
| 1968-08-07 | vs CIN | 113 | W 3-1 | 73-40 | 1 | 24,995 | Mel Nelson | George Culver | Mel Nelson | George Culver | Dick Hughes | 417 | 309 | 108 |
| 1968-08-08 | vs CIN | 114 | W 1-0 | 74-40 | 1 | 24,324 | Ray Washburn | Tony Cloninger | Joe Hoerner | Clay Carroll | | 418 | 309 | 109 |
| 1968-08-09 | @ ATL | 115 | W 1-0 | 75-40 | 1 | 41,267 | Bob Gibson | Phil Niekro | Bob Gibson | Phil Niekro | | 419 | 309 | 110 |
| 1968-08-10 | @ ATL | 116 | W 7-1 | 76-40 | 1 | 31,094 | Nelson Briles | Milt Pappas | Nelson Briles | Milt Pappas | | 426 | 310 | 116 |
| 1968-08-11 | @ ATL | 117 | L 3-5 | 76-41 | 1 | 34,874 | Steve Carlton | Pat Jarvis | Pat Jarvis | Steve Carlton | Phil Niekro | 429 | 315 | 114 |
| 1968-08-12 | @ CHN | 118 | L 3-7 | 76-42 | 1 | 30,693 | Larry Jaster | Bill Hands | Bill Hands | Larry Jaster | | 432 | 322 | 110 |
| 1968-08-13 | @ CHN | 119 | L 3-10 | 76-43 | 1 | 35,198 | Ray Washburn | Fergie Jenkins | Fergie Jenkins | Ray Washburn | | 435 | 332 | 103 |
| 1968-08-14 | @ CHN | 120 | W 3-1 | 77-43 | 1 | 32,733 | Bob Gibson | Joe Niekro | Bob Gibson | Joe Niekro | | 438 | 333 | 105 |
| 1968-08-15 | @ CHN | 121 | W 8-0 | 78-43 | 1 | 23,116 | Nelson Briles | Ken Holtzman | Nelson Briles | Ken Holtzman | | 446 | 333 | 113 |
| 1968-08-16 | vs ATL | 122 | L 1-5 | 78-44 | 1 | 42,580 | Steve Carlton | Milt Pappas | Milt Pappas | Steve Carlton | Claude Raymond | 447 | 338 | 109 |
| 1968-08-17 | vs ATL | 123 | L 2-3 | 78-45 | 1 | 46,537 | Larry Jaster | Pat Jarvis | Pat Jarvis | Larry Jaster | | 449 | 341 | 108 |
| 1968-08-18 | vs ATL | 124 | W 10-1 | 79-45 | 1 | 37,571 | Ray Washburn | Ron Reed | Ray Washburn | Ron Reed | | 459 | 342 | 117 |
| 1968-08-19 | @ PHI | 125 | W 2-0 | 80-45 | 1 | 12,278 | Bob Gibson | Woodie Fryman | Bob Gibson | Woodie Fryman | | 461 | 342 | 119 |
| 1968-08-20 | @ PHI | 126 | L 2-8 | 80-46 | 1 | 9,379 | Nelson Briles | Larry Jackson | Larry Jackson | Nelson Briles | | 463 | 350 | 113 |
| 1968-08-21 | @ PHI | 127 | W 8-3 | 81-46 | 1 | 9,500 | Steve Carlton | Jerry Johnson | Dick Hughes | Jerry Johnson | Joe Hoerner | 471 | 353 | 118 |
| 1968-08-22 | @ PHI | 128 | L 3-7 | 81-47 | 1 | 10,193 | Larry Jaster | Chris Short | Chris Short | Larry Jaster | | 474 | 360 | 114 |
| 1968-08-23 | vs PIT | 129 | W 3-2 | 82-47 | 1 | 34,845 | Ray Washburn | Bob Veale | Joe Hoerner | Ron Kline | | 477 | 362 | 115 |
| 1968-08-24 | vs PIT | 130 | L 4-6 | 82-48 | 1 | 31,019 | Bob Gibson | Bob Moose | Roy Face | Bob Gibson | | 481 | 368 | 113 |
| 1968-08-25 | vs PIT | 131 | W 4-2 | 83-48 | 1 | 26,756 | Nelson Briles | Dock Ellis | Nelson Briles | Dock Ellis | Joe Hoerner | 485 | 370 | 115 |
| 1968-08-26 | vs NYN | 132 | L 0-1 | 83-49 | 1 | 23,340 | Steve Carlton | Jim McAndrew | Jim McAndrew | Steve Carlton | | 485 | 371 | 114 |
| 1968-08-27 | vs NYN | 133 | L 0-4 | 83-50 | 1 | 27,541 | Larry Jaster | Dick Selma | Dick Selma | Larry Jaster | | 485 | 375 | 110 |
| 1968-08-28 | @ PIT | 134 | W 8-0 | 84-50 | 1 | 11,197 | Bob Gibson | Bob Veale | Bob Gibson | Bob Veale | | 493 | 375 | 118 |
| 1968-08-29 | @ PIT | 135 | W 5-0 | 85-50 | 1 | 7,681 | Ray Washburn | Bob Moose | Ray Washburn | Bob Moose | | 498 | 375 | 123 |
| 1968-08-30 | @ NYN | 136 | L 2-8 | 85-51 | 1 | 34,425 | Nelson Briles | Tom Seaver | Tom Seaver | Nelson Briles | | 500 | 383 | 117 |
| 1968-08-31 | @ NYN | 137 | W 2-0 | 86-51 | 1 | 30,714 | Steve Carlton | Jim McAndrew | Steve Carlton | Jim McAndrew | Joe Hoerner | 502 | 383 | 119 |
| 1968-09-01 | @ NYN | 138 | W 3-2 | 87-51 | 1 | 28,656 | Dick Hughes | Dick Selma | Larry Jaster | Bill Short | | 505 | 385 | 120 |
| 1968-09-02 | @ CIN | 139 | W 1-0 | 88-51 | 1 | 11,846 | Bob Gibson | Gary Nolan | Bob Gibson | Ted Abernathy | | 506 | 385 | 121 |
| 1968-09-03 | @ CIN | 140 | W 5-3 | 89-51 | 1 | 7,446 | Ray Washburn | George Culver | Joe Hoerner | Dan McGinn | Wayne Granger | 511 | 388 | 123 |
| 1968-09-04 | @ CIN | 141 | L 3-8 | 89-52 | 1 | 8,211 | Nelson Briles | Jim Maloney | Jim Maloney | Nelson Briles | Clay Carroll | 514 | 396 | 118 |
| 1968-09-06 | vs SFN | 142 | L 2-3 | 89-54 | 1 | 0 | Bob Gibson | Bobby Bolin | Bobby Bolin | Bob Gibson | Frank Linzy | 516 | 399 | 117 |
| 1968-09-06 | vs SFN | 143 | L 7-8 | 89-54 | 1 | 46,550 | Steve Carlton | Juan Marichal | Juan Marichal | Steve Carlton | Frank Linzy | 523 | 407 | 116 |
| 1968-09-07 | vs SFN | 144 | L 1-5 | 89-55 | 1 | 28,718 | Ray Washburn | Gaylord Perry | Gaylord Perry | Ray Washburn | | 524 | 412 | 112 |
| 1968-09-08 | vs SFN | 145 | W 3-2 | 90-55 | 1 | 32,926 | Nelson Briles | Mike McCormick | Joe Hoerner | Frank Linzy | | 527 | 414 | 113 |
| 1968-09-09 | vs LAN | 146 | L 1-10 | 90-56 | 1 | 13,508 | Larry Jaster | Don Sutton | Don Sutton | Larry Jaster | | 528 | 424 | 104 |
| 1968-09-10 | vs LAN | 147 | L 0-3 | 90-57 | 1 | 14,860 | Steve Carlton | Bill Singer | Bill Singer | Steve Carlton | | 528 | 427 | 101 |
| 1968-09-11 | vs LAN | 148 | W 5-4 | 91-57 | 1 | 18,835 | Bob Gibson | Mike Kekich | Bob Gibson | Mike Kekich | | 533 | 431 | 102 |
| 1968-09-13 | @ HOU | 149 | L 2-4 | 91-58 | 1 | 15,425 | Ray Washburn | Dave Giusti | Dave Giusti | Ray Washburn | Steve Shea | 535 | 435 | 100 |
| 1968-09-14 | @ HOU | 150 | W 8-0 | 92-58 | 1 | 16,324 | Nelson Briles | Larry Dierker | Nelson Briles | Larry Dierker | | 543 | 435 | 108 |
| 1968-09-15 | @ HOU | 151 | W 7-4 | 93-58 | 1 | 16,638 | Steve Carlton | Don Wilson | Steve Carlton | Don Wilson | | 550 | 439 | 111 |
| 1968-09-17 | @ SFN | 152 | L 0-1 | 93-59 | 1 | 9,546 | Bob Gibson | Gaylord Perry | Gaylord Perry | Bob Gibson | | 550 | 440 | 110 |
| 1968-09-18 | @ SFN | 153 | W 2-0 | 94-59 | 1 | 4,703 | Ray Washburn | Bobby Bolin | Ray Washburn | Bobby Bolin | | 552 | 440 | 112 |
| 1968-09-19 | @ SFN | 154 | L 5-11 | 94-60 | 1 | 4,502 | Nelson Briles | Rich Robertson | Rich Robertson | Nelson Briles | Frank Linzy | 557 | 451 | 106 |
| 1968-09-20 | @ LAN | 155 | L 4-5 | 94-61 | 1 | 17,888 | Steve Carlton | Bill Singer | Bill Singer | Ron Willis | Jim Brewer | 561 | 456 | 105 |
| 1968-09-21 | @ LAN | 156 | L 0-3 | 94-62 | 1 | 13,842 | Larry Jaster | Claude Osteen | Claude Osteen | Larry Jaster | Mudcat Grant | 561 | 459 | 102 |
| 1968-09-22 | @ LAN | 157 | L 2-3 | 94-63 | 1 | 18,529 | Bob Gibson | Don Sutton | Don Sutton | Bob Gibson | Jim Brewer | 563 | 462 | 101 |
| 1968-09-24 | vs PHI | 158 | L 1-2 | 94-64 | 1 | 10,530 | Ray Washburn | Jerry Johnson | Jerry Johnson | Ray Washburn | | 564 | 464 | 100 |
| 1968-09-25 | vs PHI | 159 | W 5-4 | 95-64 | 1 | 10,992 | Nelson Briles | Chris Short | Nelson Briles | Chris Short | Joe Hoerner | 569 | 468 | 101 |
| 1968-09-27 | vs HOU | 160 | W 1-0 | 96-64 | 1 | 18,658 | Bob Gibson | Larry Dierker | Bob Gibson | Larry Dierker | | 570 | 468 | 102 |
| 1968-09-28 | vs HOU | 161 | L 2-3 | 96-65 | 1 | 21,502 | Steve Carlton | Don Wilson | Tom Dukes | Wayne Granger | Steve Shea | 572 | 471 | 101 |
| 1968-09-29 | vs HOU | 162 | W 11-1 | 97-65 | 1 | 23,792 | Ray Washburn | Mike Cuellar | Ray Washburn | Mike Cuellar | Joe Hoerner | 583 | 472 | 111 |