| 1967-04-11 | vs MIN | 1 | W 6-3 | 1-0 | 1 | 39,812 | Dave McNally | Jim Kaat | Moe Drabowsky | Jim Kaat | Stu Miller | 6 | 3 | 3 |
| 1967-04-13 | vs MIN | 2 | W 7-1 | 2-0 | 1 | 3,842 | Jim Palmer | Dean Chance | Jim Palmer | Dean Chance | | 13 | 4 | 9 |
| 1967-04-14 | @ KC1 | 3 | W 7-1 | 3-0 | 1 | 6,814 | Tom Phoebus | Lew Krausse | Bill Dillman | Lew Krausse | | 20 | 5 | 15 |
| 1967-04-15 | @ KC1 | 4 | L 3-11 | 3-1 | 1 | 6,727 | Wally Bunker | Catfish Hunter | Catfish Hunter | Wally Bunker | | 23 | 16 | 7 |
| 1967-04-16 | @ CAL | 5 | L 4-5 | 4-2 | 1 | 0 | Dave McNally | George Brunet | Lew Burdette | Stu Miller | | 27 | 21 | 6 |
| 1967-04-16 | @ CAL | 6 | W 3-0 | 4-2 | 1 | 28,066 | Steve Barber | Jorge Rubio | Steve Barber | Jorge Rubio | | 30 | 21 | 9 |
| 1967-04-19 | @ MIN | 7 | L 2-3 | 4-3 | 3 | 5,884 | Jim Palmer | Dean Chance | Dean Chance | Stu Miller | | 32 | 24 | 8 |
| 1967-04-21 | vs KC1 | 8 | L 1-3 | 4-4 | 5 | 7,729 | Tom Phoebus | Catfish Hunter | Catfish Hunter | Tom Phoebus | Jack Aker | 33 | 27 | 6 |
| 1967-04-22 | vs KC1 | 9 | W 12-2 | 5-4 | 3 | 7,701 | Wally Bunker | Blue Moon Odom | Wally Bunker | Blue Moon Odom | Bill Dillman | 45 | 29 | 16 |
| 1967-04-23 | vs KC1 | 10 | W 5-2 | 6-5 | 3 | 0 | Steve Barber | Jim Nash | Steve Barber | Jim Nash | Stu Miller | 50 | 31 | 19 |
| 1967-04-23 | vs KC1 | 11 | L 7-8 | 6-5 | 3 | 23,965 | Dave McNally | Chuck Dobson | Jack Aker | Eddie Fisher | | 57 | 39 | 18 |
| 1967-04-25 | vs CAL | 12 | W 2-1 | 7-5 | 2 | 7,587 | Tom Phoebus | George Brunet | Tom Phoebus | George Brunet | Stu Miller | 59 | 40 | 19 |
| 1967-04-28 | vs DET | 13 | W 5-3 | 8-5 | 1 | 15,046 | Dave McNally | Denny McLain | Dave McNally | Denny McLain | Moe Drabowsky | 64 | 43 | 21 |
| 1967-04-29 | vs DET | 14 | L 2-4 | 8-6 | 3 | 6,878 | Wally Bunker | Mickey Lolich | Mickey Lolich | Wally Bunker | | 66 | 47 | 19 |
| 1967-04-30 | vs DET | 15 | L 1-2 | 8-8 | 5 | 0 | Steve Barber | Earl Wilson | Earl Wilson | Steve Barber | Fred Gladding | 67 | 49 | 18 |
| 1967-04-30 | vs DET | 16 | L 4-6 | 8-8 | 5 | 26,884 | Jim Palmer | Joe Sparma | Joe Sparma | Jim Palmer | Dave Wickersham | 71 | 55 | 16 |
| 1967-05-01 | @ CLE | 17 | W 8-7 | 9-8 | 5 | 5,349 | Tom Phoebus | Sam McDowell | Eddie Fisher | Bob Allen | | 79 | 62 | 17 |
| 1967-05-03 | @ CLE | 18 | L 1-5 | 9-9 | 5 | 5,454 | Dave McNally | Sonny Siebert | Sonny Siebert | Dave McNally | | 80 | 67 | 13 |
| 1967-05-05 | @ DET | 19 | L 0-4 | 9-10 | 7 | 20,986 | Steve Barber | Mickey Lolich | Mickey Lolich | Steve Barber | | 80 | 71 | 9 |
| 1967-05-06 | @ DET | 20 | L 1-4 | 9-11 | 8 | 13,864 | Jim Palmer | Earl Wilson | Earl Wilson | Stu Miller | | 81 | 75 | 6 |
| 1967-05-07 | @ DET | 21 | L 0-4 | 9-12 | 8 | 20,651 | Dave McNally | Joe Sparma | Joe Sparma | Dave McNally | | 81 | 79 | 2 |
| 1967-05-09 | vs CHA | 22 | L 4-5 | 9-13 | 9 | 8,145 | Tom Phoebus | Gary Peters | Gary Peters | Eddie Watt | Bob Locker | 85 | 84 | 1 |
| 1967-05-10 | vs CHA | 23 | L 1-13 | 9-14 | 9 | 9,811 | Steve Barber | Tommy John | Tommy John | Steve Barber | | 86 | 97 | -11 |
| 1967-05-12 | @ NYA | 24 | W 14-0 | 10-14 | 10 | 22,300 | Jim Palmer | Whitey Ford | Jim Palmer | Whitey Ford | | 100 | 97 | 3 |
| 1967-05-13 | @ NYA | 25 | W 5-3 | 11-14 | 10 | 18,355 | Dave McNally | Al Downing | Moe Drabowsky | Al Downing | Eddie Watt | 105 | 100 | 5 |
| 1967-05-14 | @ NYA | 26 | L 5-6 | 11-15 | 10 | 18,872 | Steve Barber | Mel Stottlemyre | Dooley Womack | Stu Miller | | 110 | 106 | 4 |
| 1967-05-16 | @ BOS | 27 | W 8-5 | 12-15 | 9 | 9,510 | Tom Phoebus | Bucky Brandon | Eddie Fisher | John Wyatt | Stu Miller | 118 | 111 | 7 |
| 1967-05-17 | @ BOS | 28 | W 12-8 | 13-15 | 6 | 8,714 | Jim Palmer | Dennis Bennett | Bill Dillman | Galen Cisco | Moe Drabowsky | 130 | 119 | 11 |
| 1967-05-18 | @ WS2 | 29 | L 0-2 | 13-16 | 7 | 7,291 | Frank Bertaina | Pete Richert | Pete Richert | Frank Bertaina | | 130 | 121 | 9 |
| 1967-05-19 | @ WS2 | 30 | W 11-5 | 14-16 | 4 | 12,072 | Steve Barber | Phil Ortega | Steve Barber | Phil Ortega | Wally Bunker | 141 | 126 | 15 |
| 1967-05-20 | @ WS2 | 31 | W 4-3 | 15-16 | 4 | 7,001 | Dave McNally | Joe Coleman | Dave McNally | Joe Coleman | Moe Drabowsky | 145 | 129 | 16 |
| 1967-05-22 | vs NYA | 32 | W 7-0 | 16-16 | 3 | 11,605 | Tom Phoebus | Fred Talbot | Tom Phoebus | Fred Talbot | | 152 | 129 | 23 |
| 1967-05-23 | vs NYA | 33 | W 1-0 | 17-16 | 3 | 14,617 | Frank Bertaina | Mel Stottlemyre | Frank Bertaina | Mel Stottlemyre | Eddie Watt | 153 | 129 | 24 |
| 1967-05-24 | vs NYA | 34 | L 0-2 | 17-17 | 4 | 12,449 | Steve Barber | Al Downing | Al Downing | Steve Barber | | 153 | 131 | 22 |
| 1967-05-26 | vs BOS | 35 | W 4-3 | 18-17 | 3 | 13,786 | Dave McNally | Billy Rohr | Moe Drabowsky | Billy Rohr | | 157 | 134 | 23 |
| 1967-05-27 | vs BOS | 36 | W 10-0 | 19-17 | 3 | 26,488 | Tom Phoebus | Bucky Brandon | Tom Phoebus | Bucky Brandon | | 167 | 134 | 33 |
| 1967-05-28 | vs BOS | 37 | L 3-4 | 19-18 | 3 | 14,071 | Steve Barber | Jim Lonborg | Jim Lonborg | Steve Barber | John Wyatt | 170 | 138 | 32 |
| 1967-05-30 | vs CLE | 38 | W 5-4 | 20-19 | 3 | 0 | Dave McNally | Steve Hargan | Dave McNally | Steve Hargan | Eddie Watt | 175 | 142 | 33 |
| 1967-05-30 | vs CLE | 39 | L 2-3 | 20-19 | 3 | 28,385 | Wally Bunker | Sam McDowell | Sam McDowell | Wally Bunker | | 177 | 145 | 32 |
| 1967-05-31 | @ CHA | 40 | L 2-3 | 20-20 | 5 | 13,782 | Bill Dillman | Jim O'Toole | Hoyt Wilhelm | Eddie Watt | | 179 | 148 | 31 |
| 1967-06-02 | vs WS2 | 41 | W 12-0 | 21-20 | 4 | 19,838 | Tom Phoebus | Darold Knowles | Tom Phoebus | Darold Knowles | | 191 | 148 | 43 |
| 1967-06-03 | vs WS2 | 42 | W 3-2 | 22-20 | 4 | 20,364 | Pete Richert | Barry Moore | Moe Drabowsky | Darold Knowles | | 194 | 150 | 44 |
| 1967-06-04 | vs WS2 | 43 | W 7-5 | 23-20 | 3 | 12,612 | Steve Barber | Phil Ortega | Stu Miller | Bob Priddy | | 201 | 155 | 46 |
| 1967-06-05 | @ CAL | 44 | L 2-3 | 23-21 | 3 | 9,788 | Dave McNally | Nick Willhite | Bill Kelso | Dave McNally | | 203 | 158 | 45 |
| 1967-06-06 | @ CAL | 45 | W 16-4 | 25-21 | 3 | 0 | Bill Dillman | Pete Cimino | Bill Dillman | Pete Cimino | Moe Drabowsky | 219 | 162 | 57 |
| 1967-06-06 | @ CAL | 46 | W 11-1 | 25-21 | 3 | 14,071 | Tom Phoebus | Rickey Clark | Tom Phoebus | Rickey Clark | | 230 | 163 | 67 |
| 1967-06-07 | @ CAL | 47 | L 0-2 | 25-22 | 3 | 10,963 | Pete Richert | Jim McGlothlin | Jim McGlothlin | Pete Richert | | 230 | 165 | 65 |
| 1967-06-08 | @ CAL | 48 | L 5-6 | 25-23 | 3 | 7,877 | Jim Palmer | Rickey Clark | Pete Cimino | Stu Miller | Minnie Rojas | 235 | 171 | 64 |
| 1967-06-09 | @ MIN | 49 | W 11-2 | 26-23 | 3 | 19,144 | Dave McNally | Dean Chance | Moe Drabowsky | Dean Chance | | 246 | 173 | 73 |
| 1967-06-10 | @ MIN | 50 | L 1-8 | 26-24 | 3 | 8,813 | Tom Phoebus | Jim Kaat | Jim Kaat | Tom Phoebus | | 247 | 181 | 66 |
| 1967-06-11 | @ MIN | 51 | W 5-2 | 27-25 | 3 | 0 | Bill Dillman | Dave Boswell | Bill Dillman | Dave Boswell | | 252 | 183 | 69 |
| 1967-06-11 | @ MIN | 52 | L 7-10 | 27-25 | 3 | 22,157 | Wally Bunker | Mudcat Grant | Jim Perry | Eddie Watt | Al Worthington | 259 | 193 | 66 |
| 1967-06-12 | @ KC1 | 53 | W 10-2 | 28-25 | 3 | 5,726 | Pete Richert | Lew Krausse | Pete Richert | Lew Krausse | | 269 | 195 | 74 |
| 1967-06-13 | @ KC1 | 54 | L 0-1 | 28-26 | 3 | 8,735 | Steve Barber | Catfish Hunter | Catfish Hunter | Steve Barber | | 269 | 196 | 73 |
| 1967-06-14 | @ KC1 | 55 | L 2-9 | 28-27 | 3 | 12,096 | Dave McNally | Chuck Dobson | Chuck Dobson | Dave McNally | Jack Aker | 271 | 205 | 66 |
| 1967-06-15 | @ KC1 | 56 | L 5-6 | 28-28 | 5 | 9,523 | Tom Phoebus | Jim Nash | Diego Segui | Eddie Watt | | 276 | 211 | 65 |
| 1967-06-16 | vs CAL | 57 | L 1-2 | 28-30 | 8 | 0 | Pete Richert | Jack Hamilton | Minnie Rojas | Pete Richert | | 277 | 213 | 64 |
| 1967-06-16 | vs CAL | 58 | L 3-5 | 28-30 | 8 | 16,313 | Bill Dillman | Jim McGlothlin | Ken Turner | Bill Dillman | | 280 | 218 | 62 |
| 1967-06-17 | vs CAL | 59 | W 7-5 | 29-30 | 6 | 21,089 | Steve Barber | George Brunet | Steve Barber | George Brunet | Eddie Watt | 287 | 223 | 64 |
| 1967-06-18 | vs CAL | 60 | L 3-5 | 29-31 | 7 | 12,121 | Dave McNally | Rickey Clark | Rickey Clark | Dave McNally | Minnie Rojas | 290 | 228 | 62 |
| 1967-06-19 | vs MIN | 61 | L 0-4 | 30-32 | 6 | 0 | Tom Phoebus | Dave Boswell | Dave Boswell | Tom Phoebus | | 290 | 232 | 58 |
| 1967-06-19 | vs MIN | 62 | W 9-5 | 30-32 | 6 | 13,390 | Wally Bunker | Mudcat Grant | Wally Bunker | Mudcat Grant | Bill Dillman | 299 | 237 | 62 |
| 1967-06-21 | vs KC1 | 63 | W 5-4 | 31-32 | 6 | 19,213 | Pete Richert | Paul Lindblad | Pete Richert | Jack Sanford | Eddie Watt | 304 | 241 | 63 |
| 1967-06-23 | @ WS2 | 64 | L 2-3 | 31-33 | 7 | 17,693 | Steve Barber | Phil Ortega | Phil Ortega | Steve Barber | Darold Knowles | 306 | 244 | 62 |
| 1967-06-24 | vs WS2 | 65 | L 3-8 | 31-34 | 7 | 15,607 | Bill Dillman | Camilo Pascual | Camilo Pascual | Bill Dillman | Bob Humphreys | 309 | 252 | 57 |
| 1967-06-25 | @ WS2 | 66 | W 8-3 | 32-34 | 7 | 19,132 | Tom Phoebus | Bob Priddy | Tom Phoebus | Bob Priddy | Moe Drabowsky | 317 | 255 | 62 |
| 1967-06-26 | vs CHA | 67 | L 4-5 | 32-35 | 8 | 13,908 | Pete Richert | Bruce Howard | Bob Locker | Stu Miller | Hoyt Wilhelm | 321 | 260 | 61 |
| 1967-06-27 | vs CHA | 68 | L 0-5 | 32-36 | 8 | 14,347 | Steve Barber | Joe Horlen | Joe Horlen | Steve Barber | | 321 | 265 | 56 |
| 1967-06-28 | vs CHA | 69 | L 2-3 | 32-37 | 8 | 31,214 | Bill Dillman | Gary Peters | Bob Locker | Bill Dillman | Hoyt Wilhelm | 323 | 268 | 55 |
| 1967-06-29 | vs CHA | 70 | W 4-1 | 33-37 | 8 | 5,065 | Tom Phoebus | Jim O'Toole | Tom Phoebus | Jim O'Toole | | 327 | 269 | 58 |
| 1967-06-30 | vs CLE | 71 | L 5-6 | 34-38 | 7 | 0 | Pete Richert | Steve Hargan | George Culver | Wally Bunker | Orlando Pena | 332 | 275 | 57 |
| 1967-06-30 | vs CLE | 72 | W 8-1 | 34-38 | 7 | 14,290 | Dave McNally | Orlando Pena | Dave McNally | Orlando Pena | Eddie Watt | 340 | 276 | 64 |
| 1967-07-01 | vs CLE | 73 | L 0-6 | 34-39 | 8 | 12,657 | Steve Barber | Sonny Siebert | John O'Donoghue | Steve Barber | | 340 | 282 | 58 |
| 1967-07-02 | vs CLE | 74 | W 1-0 | 35-39 | 7 | 12,435 | Bill Dillman | Sam McDowell | Bill Dillman | Sam McDowell | | 341 | 282 | 59 |
| 1967-07-03 | @ CHA | 75 | W 1-0 | 36-39 | 7 | 25,576 | Tom Phoebus | Bruce Howard | Moe Drabowsky | John Buzhardt | | 342 | 282 | 60 |
| 1967-07-04 | @ CHA | 76 | L 0-4 | 36-40 | 7 | 25,613 | Pete Richert | Tommy John | Tommy John | Pete Richert | | 342 | 286 | 56 |
| 1967-07-05 | @ CHA | 77 | L 2-3 | 36-41 | 7 | 13,800 | Mike Adamson | Joe Horlen | Bob Locker | Stu Miller | | 344 | 289 | 55 |
| 1967-07-06 | @ CHA | 78 | W 3-1 | 37-41 | 7 | 17,960 | Dave McNally | Jim O'Toole | Dave McNally | Jim O'Toole | | 347 | 290 | 57 |
| 1967-07-07 | vs NYA | 79 | L 0-3 | 37-42 | 7 | 19,259 | Bill Dillman | Al Downing | Al Downing | Eddie Fisher | | 347 | 293 | 54 |
| 1967-07-08 | vs NYA | 80 | W 12-5 | 38-43 | 7 | 0 | Tom Phoebus | Steve Barber | Eddie Watt | Steve Barber | Moe Drabowsky | 359 | 298 | 61 |
| 1967-07-08 | vs NYA | 81 | L 1-3 | 38-43 | 7 | 24,330 | Wally Bunker | Bill Monbouquette | Fritz Peterson | Stu Miller | Dooley Womack | 360 | 301 | 59 |
| 1967-07-09 | vs NYA | 82 | W 2-1 | 39-43 | 7 | 20,124 | Pete Richert | Mel Stottlemyre | Pete Richert | Mel Stottlemyre | Eddie Fisher | 362 | 302 | 60 |
| 1967-07-13 | @ BOS | 83 | L 2-4 | 40-44 | 7 | 19,171 | Tom Phoebus | Lee Stange | Lee Stange | Tom Phoebus | John Wyatt | 364 | 306 | 58 |
| 1967-07-13 | @ BOS | 84 | W 10-0 | 40-44 | 7 | 23,111 | Dave McNally | Gary Bell | Dave McNally | Gary Bell | | 374 | 306 | 68 |
| 1967-07-14 | @ BOS | 85 | L 5-11 | 40-45 | 7 | 27,787 | Mike Adamson | Jim Lonborg | Jim Lonborg | Mike Adamson | John Wyatt | 379 | 317 | 62 |
| 1967-07-15 | @ BOS | 86 | L 1-5 | 40-46 | 7 | 16,025 | Pete Richert | Gary Waslewski | Jose Santiago | Pete Richert | Gary Bell | 380 | 322 | 58 |
| 1967-07-16 | @ NYA | 87 | W 2-1 | 41-46 | 7 | 21,695 | Bill Dillman | Fred Talbot | Pete Richert | Dooley Womack | | 382 | 323 | 59 |
| 1967-07-17 | @ NYA | 88 | W 6-1 | 42-46 | 6 | 14,962 | Tom Phoebus | Mel Stottlemyre | Tom Phoebus | Mel Stottlemyre | | 388 | 324 | 64 |
| 1967-07-18 | vs BOS | 89 | L 2-6 | 42-47 | 6 | 14,409 | Dave McNally | Jim Lonborg | Jim Lonborg | Dave McNally | | 390 | 330 | 60 |
| 1967-07-19 | vs BOS | 90 | L 4-6 | 42-48 | 8 | 12,154 | Pete Richert | Gary Bell | Jose Santiago | Pete Richert | | 394 | 336 | 58 |
| 1967-07-21 | vs WS2 | 91 | L 3-4 | 42-50 | 8 | 0 | Tom Phoebus | Frank Bertaina | Bob Humphreys | Tom Phoebus | Darold Knowles | 397 | 340 | 57 |
| 1967-07-21 | vs WS2 | 92 | L 1-3 | 42-50 | 8 | 9,404 | Dave McNally | Joe Coleman | Joe Coleman | Dave McNally | Darold Knowles | 398 | 343 | 55 |
| 1967-07-22 | vs WS2 | 93 | L 5-7 | 42-51 | 8 | 12,644 | Gene Brabender | Camilo Pascual | Camilo Pascual | Gene Brabender | Dick Lines | 403 | 350 | 53 |
| 1967-07-23 | @ WS2 | 94 | W 7-3 | 43-51 | 8 | 26,012 | Jim Hardin | Phil Ortega | Eddie Fisher | Dave Baldwin | | 410 | 353 | 57 |
| 1967-07-27 | vs DET | 95 | L 0-4 | 43-52 | 8 | 5,649 | Tom Phoebus | Denny McLain | Denny McLain | Tom Phoebus | | 410 | 357 | 53 |
| 1967-07-28 | @ CLE | 96 | L 0-1 | 43-53 | 8 | 10,035 | Gene Brabender | Steve Hargan | Steve Hargan | Moe Drabowsky | | 410 | 358 | 52 |
| 1967-07-29 | @ CLE | 97 | W 5-3 | 44-53 | 8 | 7,942 | Jim Hardin | John O'Donoghue | Jim Hardin | John O'Donoghue | Eddie Watt | 415 | 361 | 54 |
| 1967-07-30 | @ CLE | 98 | L 3-8 | 45-54 | 8 | 0 | Bill Dillman | Sam McDowell | Sam McDowell | Bill Dillman | | 418 | 369 | 49 |
| 1967-07-30 | @ CLE | 99 | W 4-2 | 45-54 | 8 | 11,538 | Marcelino Lopez | Stan Williams | Stu Miller | Stan Williams | Moe Drabowsky | 422 | 371 | 51 |
| 1967-08-01 | vs DET | 100 | L 2-4 | 45-55 | 8 | 10,342 | Tom Phoebus | Earl Wilson | Earl Wilson | Tom Phoebus | John Hiller | 424 | 375 | 49 |
| 1967-08-02 | vs DET | 101 | L 2-4 | 46-56 | 8 | 0 | Gene Brabender | Joe Sparma | Joe Sparma | Gene Brabender | John Hiller | 426 | 379 | 47 |
| 1967-08-02 | vs DET | 102 | W 2-1 | 46-56 | 8 | 12,001 | Jim Hardin | Fred Gladding | Moe Drabowsky | Pat Dobson | | 428 | 380 | 48 |
| 1967-08-03 | vs DET | 103 | L 0-5 | 46-57 | 9 | 9,168 | Bill Dillman | Denny McLain | Denny McLain | Bill Dillman | | 428 | 385 | 43 |
| 1967-08-06 | vs CHA | 104 | W 5-2 | 48-57 | 8 | 0 | Marcelino Lopez | Bruce Howard | Wally Bunker | Bruce Howard | Moe Drabowsky | 433 | 387 | 46 |
| 1967-08-06 | vs CHA | 105 | W 4-0 | 48-57 | 8 | 18,339 | Tom Phoebus | Wilbur Wood | Tom Phoebus | Wilbur Wood | | 437 | 387 | 50 |
| 1967-08-07 | vs CLE | 106 | W 4-0 | 49-57 | 7 | 8,811 | Gene Brabender | John O'Donoghue | Gene Brabender | John O'Donoghue | | 441 | 387 | 54 |
| 1967-08-08 | vs CLE | 107 | L 3-5 | 49-58 | 8 | 8,980 | Jim Hardin | Ed Connolly | Ed Connolly | Stu Miller | Sonny Siebert | 444 | 392 | 52 |
| 1967-08-09 | vs CLE | 108 | L 3-4 | 49-59 | 8 | 9,953 | Bill Dillman | Sam McDowell | Sam McDowell | Bill Dillman | Sonny Siebert | 447 | 396 | 51 |
| 1967-08-10 | @ CLE | 109 | L 1-2 | 49-60 | 8 | 9,524 | Dave McNally | Stan Williams | Stan Williams | Moe Drabowsky | | 448 | 398 | 50 |
| 1967-08-11 | @ DET | 110 | W 5-1 | 50-61 | 9 | 0 | Tom Phoebus | Dave Wickersham | Tom Phoebus | Dave Wickersham | Stu Miller | 453 | 399 | 54 |
| 1967-08-11 | @ DET | 111 | L 2-5 | 50-61 | 9 | 23,890 | Pete Richert | Mickey Lolich | Mickey Lolich | Pete Richert | | 455 | 404 | 51 |
| 1967-08-12 | @ DET | 112 | L 4-5 | 50-62 | 9 | 14,536 | Gene Brabender | Denny McLain | Denny McLain | Gene Brabender | John Hiller | 459 | 409 | 50 |
| 1967-08-13 | @ DET | 113 | L 2-3 | 50-63 | 9 | 21,114 | Jim Hardin | Earl Wilson | Earl Wilson | Jim Hardin | Fred Lasher | 461 | 412 | 49 |
| 1967-08-14 | @ NYA | 114 | L 4-5 | 50-64 | 9 | 12,723 | Bill Dillman | Steve Barber | Steve Barber | Bill Dillman | Bill Monbouquette | 465 | 417 | 48 |
| 1967-08-15 | @ NYA | 115 | W 11-10 | 51-64 | 9 | 13,182 | Dave McNally | Mel Stottlemyre | Pete Richert | Fritz Peterson | | 476 | 427 | 49 |
| 1967-08-16 | @ NYA | 116 | W 5-4 | 52-64 | 9 | 12,692 | Tom Phoebus | Al Downing | Tom Phoebus | Al Downing | Stu Miller | 481 | 431 | 50 |
| 1967-08-17 | @ NYA | 117 | W 4-1 | 53-64 | 8 | 16,056 | Gene Brabender | Fritz Peterson | Gene Brabender | Fritz Peterson | | 485 | 432 | 53 |
| 1967-08-18 | @ CHA | 118 | L 1-3 | 54-65 | 8 | 0 | Pete Richert | Joe Horlen | Joe Horlen | Moe Drabowsky | Hoyt Wilhelm | 486 | 435 | 51 |
| 1967-08-18 | @ CHA | 119 | W 8-2 | 54-65 | 8 | 23,754 | Jim Hardin | Bruce Howard | Jim Hardin | Bruce Howard | | 494 | 437 | 57 |
| 1967-08-20 | @ CHA | 120 | L 2-4 | 54-67 | 9 | 0 | Tom Phoebus | Gary Peters | Gary Peters | Tom Phoebus | Bob Locker | 496 | 441 | 55 |
| 1967-08-20 | @ CHA | 121 | L 1-2 | 54-67 | 9 | 23,438 | Wally Bunker | Tommy John | Don McMahon | Wally Bunker | | 497 | 443 | 54 |
| 1967-08-21 | vs KC1 | 122 | W 5-2 | 55-67 | 8 | 6,272 | Gene Brabender | Chuck Dobson | Gene Brabender | Chuck Dobson | | 502 | 445 | 57 |
| 1967-08-22 | vs KC1 | 123 | W 2-1 | 56-68 | 8 | 0 | Jim Hardin | Blue Moon Odom | Jim Hardin | Blue Moon Odom | Moe Drabowsky | 504 | 446 | 58 |
| 1967-08-22 | vs KC1 | 124 | L 1-6 | 56-68 | 8 | 8,353 | Bill Dillman | Catfish Hunter | Catfish Hunter | Bill Dillman | Roberto Rodriguez | 505 | 452 | 53 |
| 1967-08-23 | vs KC1 | 125 | W 1-0 | 57-68 | 8 | 10,842 | Pete Richert | Jim Nash | Pete Richert | Jim Nash | | 506 | 452 | 54 |
| 1967-08-26 | vs CAL | 126 | L 4-5 | 57-69 | 8 | 11,309 | Tom Phoebus | Jim McGlothlin | Jim McGlothlin | Moe Drabowsky | Minnie Rojas | 510 | 457 | 53 |
| 1967-08-28 | @ MIN | 127 | L 2-3 | 57-70 | 9 | 27,723 | Pete Richert | Jim Perry | Jim Perry | Pete Richert | Al Worthington | 512 | 460 | 52 |
| 1967-08-29 | @ MIN | 128 | W 4-3 | 58-70 | 8 | 26,291 | Jim Hardin | Dave Boswell | Jim Hardin | Dave Boswell | Moe Drabowsky | 516 | 463 | 53 |
| 1967-08-30 | @ MIN | 129 | W 4-2 | 59-70 | 8 | 26,034 | Gene Brabender | Dean Chance | Eddie Watt | Dean Chance | | 520 | 465 | 55 |
| 1967-08-31 | @ MIN | 130 | L 9-10 | 59-71 | 8 | 21,911 | Tom Phoebus | Jim Merritt | Ron Kline | Moe Drabowsky | | 529 | 475 | 54 |
| 1967-09-01 | @ KC1 | 131 | W 2-1 | 60-71 | 8 | 3,711 | Pete Richert | Catfish Hunter | Pete Richert | Catfish Hunter | | 531 | 476 | 55 |
| 1967-09-02 | @ KC1 | 132 | L 6-8 | 60-72 | 8 | 3,821 | Wally Bunker | Roberto Rodriguez | Diego Segui | Wally Bunker | Lew Krausse | 537 | 484 | 53 |
| 1967-09-03 | @ KC1 | 133 | W 6-0 | 61-72 | 8 | 5,841 | Jim Hardin | Blue Moon Odom | Jim Hardin | Blue Moon Odom | | 543 | 484 | 59 |
| 1967-09-04 | @ CAL | 134 | W 4-2 | 62-73 | 8 | 0 | Gene Brabender | Jack Hamilton | Gene Brabender | Jack Hamilton | Stu Miller | 547 | 486 | 61 |
| 1967-09-04 | @ CAL | 135 | L 4-5 | 62-73 | 8 | 18,964 | Tom Phoebus | Jim McGlothlin | Jim Weaver | Eddie Fisher | | 551 | 491 | 60 |
| 1967-09-05 | @ CAL | 136 | L 2-7 | 62-75 | 8 | 0 | Pete Richert | Clyde Wright | Clyde Wright | Pete Richert | | 553 | 498 | 55 |
| 1967-09-05 | @ CAL | 137 | L 4-11 | 62-75 | 8 | 8,840 | John Buzhardt | Bobby Locke | Bobby Locke | John Buzhardt | Bill Kelso | 557 | 509 | 48 |
| 1967-09-07 | vs MIN | 138 | L 2-4 | 62-76 | 8 | 8,541 | Jim Hardin | Dean Chance | Dean Chance | Jim Hardin | | 559 | 513 | 46 |
| 1967-09-08 | vs MIN | 139 | L 2-7 | 63-77 | 8 | 0 | Gene Brabender | Jim Merritt | Jim Merritt | Gene Brabender | | 561 | 520 | 41 |
| 1967-09-08 | vs MIN | 140 | W 5-3 | 63-77 | 8 | 14,226 | Tom Phoebus | Jim Perry | Tom Phoebus | Jim Perry | Pete Richert | 566 | 523 | 43 |
| 1967-09-09 | vs MIN | 141 | L 2-3 | 63-78 | 8 | 8,277 | Bill Dillman | Jim Kaat | Jim Kaat | Bill Dillman | | 568 | 526 | 42 |
| 1967-09-10 | vs MIN | 142 | L 2-4 | 63-79 | 8 | 7,838 | Jim Palmer | Dave Boswell | Dave Boswell | Wally Bunker | | 570 | 530 | 40 |
| 1967-09-11 | @ CHA | 143 | W 6-1 | 64-79 | 8 | 4,048 | Jim Hardin | Fred Klages | Jim Hardin | Fred Klages | | 576 | 531 | 45 |
| 1967-09-12 | @ DET | 144 | L 4-6 | 64-80 | 8 | 16,224 | Gene Brabender | Earl Wilson | Fred Gladding | Eddie Watt | Fred Lasher | 580 | 537 | 43 |
| 1967-09-13 | @ DET | 145 | L 1-6 | 64-81 | 9 | 16,719 | Pete Richert | Mickey Lolich | Mickey Lolich | Pete Richert | | 581 | 543 | 38 |
| 1967-09-15 | @ BOS | 146 | W 6-2 | 65-81 | 9 | 32,489 | Tom Phoebus | Dave Morehead | Tom Phoebus | Dave Morehead | Moe Drabowsky | 587 | 545 | 42 |
| 1967-09-16 | @ BOS | 147 | W 4-1 | 66-81 | 8 | 27,219 | Jim Hardin | Jim Lonborg | Jim Hardin | Jim Lonborg | | 591 | 546 | 45 |
| 1967-09-17 | @ BOS | 148 | W 5-2 | 67-81 | 8 | 30,301 | Gene Brabender | Gary Bell | Gene Brabender | Gary Bell | Stu Miller | 596 | 548 | 48 |
| 1967-09-18 | vs NYA | 149 | W 2-0 | 68-81 | 8 | 6,593 | Dave McNally | Bill Monbouquette | Dave McNally | Bill Monbouquette | Bill Dillman | 598 | 548 | 50 |
| 1967-09-19 | vs NYA | 150 | W 3-0 | 69-81 | 8 | 5,641 | Jim Palmer | Steve Barber | Jim Palmer | Steve Barber | Pete Richert | 601 | 548 | 53 |
| 1967-09-20 | @ WS2 | 151 | W 4-3 | 71-81 | 7 | 0 | Tom Phoebus | Dick Bosman | Tom Phoebus | Dick Bosman | Moe Drabowsky | 605 | 551 | 54 |
| 1967-09-20 | @ WS2 | 152 | W 6-3 | 71-81 | 7 | 3,765 | Marcelino Lopez | Buster Narum | Eddie Fisher | Darold Knowles | | 611 | 554 | 57 |
| 1967-09-21 | @ WS2 | 153 | L 3-4 | 71-82 | 7 | 1,718 | Dave Leonhard | Bob Priddy | Dave Baldwin | Stu Miller | | 614 | 558 | 56 |
| 1967-09-22 | vs BOS | 154 | W 10-0 | 72-83 | 7 | 0 | Jim Hardin | Jerry Stephenson | Jim Hardin | Jerry Stephenson | | 624 | 558 | 66 |
| 1967-09-22 | vs BOS | 155 | L 3-10 | 72-83 | 7 | 14,714 | Pete Richert | Jose Santiago | Jose Santiago | Pete Richert | | 627 | 568 | 59 |
| 1967-09-23 | vs BOS | 156 | W 7-5 | 73-83 | 6 | 10,251 | Gene Brabender | Lee Stange | Stu Miller | John Wyatt | | 634 | 573 | 61 |
| 1967-09-24 | vs BOS | 157 | L 7-11 | 73-84 | 6 | 5,609 | Tom Phoebus | Jim Lonborg | Jim Lonborg | Tom Phoebus | Dan Osinski | 641 | 584 | 57 |
| 1967-09-25 | vs WS2 | 158 | W 3-2 | 74-84 | 6 | 2,741 | Dave Leonhard | Dick Bosman | Eddie Watt | Dave Baldwin | | 644 | 586 | 58 |
| 1967-09-26 | vs WS2 | 159 | L 1-4 | 74-85 | 6 | 4,864 | Jim Hardin | Buster Narum | Buster Narum | Jim Hardin | Darold Knowles | 645 | 590 | 55 |
| 1967-09-30 | @ CLE | 160 | W 5-2 | 75-85 | 6 | 2,323 | Gene Brabender | Sam McDowell | Gene Brabender | Sam McDowell | Eddie Watt | 650 | 592 | 58 |
| 1967-10-01 | @ CLE | 161 | W 4-0 | 76-85 | 6 | 15,552 | Marcelino Lopez | John O'Donoghue | Marcelino Lopez | John O'Donoghue | Dave Leonhard | 654 | 592 | 62 |