| 1965-04-12 | @ PIT | 1 | L 0-1 | 0-1 | 9 | 28,189 | Juan Marichal | Bob Veale | Bob Veale | Juan Marichal | | 0 | 1 | -1 |
| 1965-04-13 | @ PIT | 2 | L 2-5 | 0-2 | 9 | 4,444 | Jack Sanford | Bob Friend | Bob Friend | Jack Sanford | Al McBean | 2 | 6 | -4 |
| 1965-04-14 | @ PHI | 3 | W 5-2 | 1-2 | 8 | 31,922 | Gaylord Perry | Jim Bunning | Gaylord Perry | Jim Bunning | Bob Shaw | 7 | 8 | -1 |
| 1965-04-17 | @ NYN | 4 | W 4-0 | 2-2 | 6 | 34,945 | Juan Marichal | Tom Parsons | Juan Marichal | Tom Parsons | | 11 | 8 | 3 |
| 1965-04-18 | @ NYN | 5 | W 4-1 | 3-3 | 6 | 0 | Jack Sanford | Al Jackson | Jack Sanford | Al Jackson | Bob Shaw | 15 | 9 | 6 |
| 1965-04-18 | @ NYN | 6 | L 1-7 | 3-3 | 6 | 44,179 | Gaylord Perry | Gary Kroll | Gary Kroll | Gaylord Perry | | 16 | 16 | 0 |
| 1965-04-20 | vs PIT | 7 | L 1-3 | 3-4 | 8 | 37,784 | Bobby Bolin | Bob Friend | Bob Friend | Bobby Bolin | Al McBean | 17 | 19 | -2 |
| 1965-04-21 | vs PIT | 8 | W 3-2 | 4-4 | 6 | 12,022 | Juan Marichal | Joe Gibbon | Juan Marichal | Joe Gibbon | | 20 | 21 | -1 |
| 1965-04-23 | vs NYN | 9 | L 8-9 | 4-5 | 6 | 14,037 | Gaylord Perry | Gary Kroll | Dennis Ribant | Jim Duffalo | | 28 | 30 | -2 |
| 1965-04-24 | vs NYN | 10 | L 6-7 | 4-6 | 8 | 14,702 | Jack Sanford | Tom Parsons | Gary Kroll | Bob Shaw | Dennis Ribant | 34 | 37 | -3 |
| 1965-04-25 | vs NYN | 11 | W 5-0 | 5-7 | 8 | 0 | Juan Marichal | Al Jackson | Juan Marichal | Al Jackson | | 39 | 37 | 2 |
| 1965-04-25 | vs NYN | 12 | L 3-4 | 5-7 | 8 | 33,905 | Bobby Bolin | Warren Spahn | Warren Spahn | Bobby Bolin | | 42 | 41 | 1 |
| 1965-04-27 | vs PHI | 13 | W 14-13 | 6-7 | 6 | 10,705 | Gaylord Perry | Jim Bunning | Bob Shaw | Ed Roebuck | | 56 | 54 | 2 |
| 1965-04-28 | vs PHI | 14 | W 9-3 | 7-7 | 5 | 7,922 | Jack Sanford | Ray Culp | Ron Herbel | Ray Culp | | 65 | 57 | 8 |
| 1965-04-29 | @ LAN | 15 | L 1-2 | 7-8 | 5 | 30,219 | Juan Marichal | Don Drysdale | Don Drysdale | Juan Marichal | | 66 | 59 | 7 |
| 1965-04-30 | @ LAN | 16 | L 3-6 | 7-9 | 6 | 48,586 | Bob Hendley | Sandy Koufax | Bob Miller | Bobby Bolin | | 69 | 65 | 4 |
| 1965-05-01 | @ LAN | 17 | L 2-4 | 7-10 | 6 | 49,758 | Gaylord Perry | Johnny Podres | John Purdin | Gaylord Perry | Jim Brewer | 71 | 69 | 2 |
| 1965-05-02 | @ LAN | 18 | W 4-2 | 8-10 | 8 | 40,439 | Jack Sanford | Claude Osteen | Jack Sanford | Bob Miller | Frank Linzy | 75 | 71 | 4 |
| 1965-05-03 | @ SLN | 19 | L 1-3 | 8-11 | 8 | 18,745 | Ron Herbel | Curt Simmons | Curt Simmons | Ron Herbel | | 76 | 74 | 2 |
| 1965-05-04 | @ SLN | 20 | W 9-2 | 9-11 | 7 | 10,604 | Juan Marichal | Ray Sadecki | Juan Marichal | Ray Sadecki | | 85 | 76 | 9 |
| 1965-05-05 | @ SLN | 21 | W 10-5 | 10-11 | 6 | 10,260 | Bob Hendley | Tracy Stallard | Frank Linzy | Ray Washburn | Bill Henry | 95 | 81 | 14 |
| 1965-05-07 | vs LAN | 22 | L 3-4 | 10-12 | 7 | 33,977 | Jack Sanford | Claude Osteen | Claude Osteen | Bill Henry | | 98 | 85 | 13 |
| 1965-05-08 | vs LAN | 23 | L 0-9 | 10-13 | 8 | 37,548 | Ron Herbel | Don Drysdale | Don Drysdale | Ron Herbel | | 98 | 94 | 4 |
| 1965-05-09 | vs LAN | 24 | W 6-3 | 11-13 | 7 | 40,596 | Gaylord Perry | Sandy Koufax | Juan Marichal | Sandy Koufax | | 104 | 97 | 7 |
| 1965-05-11 | vs CHN | 25 | W 3-0 | 12-13 | 6 | 9,912 | Ron Herbel | Larry Jackson | Ron Herbel | Larry Jackson | Frank Linzy | 107 | 97 | 10 |
| 1965-05-12 | vs CHN | 26 | L 3-7 | 12-14 | 7 | 6,356 | Juan Marichal | Cal Koonce | Cal Koonce | Juan Marichal | Ted Abernathy | 110 | 104 | 6 |
| 1965-05-13 | vs CHN | 27 | W 6-3 | 13-14 | 6 | 4,610 | Jack Sanford | Ernie Broglio | Jack Sanford | Ernie Broglio | Frank Linzy | 116 | 107 | 9 |
| 1965-05-14 | vs HOU | 28 | W 2-1 | 14-14 | 5 | 11,900 | Gaylord Perry | Ken Johnson | Gaylord Perry | Ken Johnson | | 118 | 108 | 10 |
| 1965-05-15 | vs HOU | 29 | W 8-2 | 15-14 | 4 | 13,177 | Ron Herbel | Larry Dierker | Bobby Bolin | Larry Dierker | | 126 | 110 | 16 |
| 1965-05-16 | vs HOU | 30 | W 10-5 | 17-14 | 3 | 0 | Juan Marichal | Dave Giusti | Juan Marichal | Dave Giusti | | 136 | 115 | 21 |
| 1965-05-16 | vs HOU | 31 | W 4-3 | 17-14 | 3 | 33,368 | Bob Shaw | Don Nottebart | Bob Shaw | Don Nottebart | Masanori Murakami | 140 | 118 | 22 |
| 1965-05-18 | @ CHN | 32 | L 6-7 | 17-15 | 3 | 4,936 | Jack Sanford | Ernie Broglio | Bob Humphreys | Ron Herbel | Ted Abernathy | 146 | 125 | 21 |
| 1965-05-19 | @ CHN | 33 | L 1-2 | 17-16 | 5 | 4,282 | Gaylord Perry | Bob Buhl | Bob Buhl | Gaylord Perry | Ted Abernathy | 147 | 127 | 20 |
| 1965-05-20 | @ CHN | 34 | W 2-0 | 18-16 | 5 | 4,451 | Bob Shaw | Larry Jackson | Bob Shaw | Larry Jackson | Masanori Murakami | 149 | 127 | 22 |
| 1965-05-21 | @ HOU | 35 | W 8-1 | 19-16 | 4 | 33,094 | Ron Herbel | Don Nottebart | Ron Herbel | Don Nottebart | | 157 | 128 | 29 |
| 1965-05-22 | @ HOU | 36 | W 10-1 | 20-17 | 4 | 22,560 | Juan Marichal | Bob Bruce | Juan Marichal | Bob Bruce | | 167 | 129 | 38 |
| 1965-05-22 | @ HOU | 37 | L 2-3 | 20-17 | 4 | 43,367 | Jack Sanford | Turk Farrell | Hal Woodeshick | Masanori Murakami | | 169 | 132 | 37 |
| 1965-05-23 | @ HOU | 38 | W 5-2 | 21-17 | 4 | 31,493 | Gaylord Perry | Ken Johnson | Gaylord Perry | Ken Johnson | Bill Henry | 174 | 134 | 40 |
| 1965-05-24 | vs MLN | 39 | L 3-4 | 21-18 | 5 | 6,643 | Bob Shaw | Hank Fischer | Hank Fischer | Bob Shaw | Clay Carroll | 177 | 138 | 39 |
| 1965-05-25 | vs MLN | 40 | L 1-14 | 21-19 | 5 | 9,784 | Ron Herbel | Wade Blasingame | Wade Blasingame | Ron Herbel | | 178 | 152 | 26 |
| 1965-05-26 | vs MLN | 41 | L 4-10 | 21-20 | 5 | 6,538 | Juan Marichal | Tony Cloninger | Tony Cloninger | Juan Marichal | | 182 | 162 | 20 |
| 1965-05-27 | vs CIN | 42 | W 9-2 | 22-20 | 5 | 7,588 | Gaylord Perry | Joe Nuxhall | Gaylord Perry | Joe Nuxhall | | 191 | 164 | 27 |
| 1965-05-28 | vs CIN | 43 | W 12-7 | 23-20 | 5 | 17,219 | Bob Shaw | John Tsitouris | Bob Shaw | John Tsitouris | | 203 | 171 | 32 |
| 1965-05-29 | vs CIN | 44 | W 6-4 | 24-20 | 4 | 17,583 | Jack Sanford | Gerry Arrigo | Bobby Bolin | Billy McCool | Frank Linzy | 209 | 175 | 34 |
| 1965-05-30 | vs SLN | 45 | W 3-2 | 25-20 | 3 | 31,919 | Ron Herbel | Bob Gibson | Frank Linzy | Bob Gibson | | 212 | 177 | 35 |
| 1965-05-31 | vs SLN | 46 | W 4-1 | 26-20 | 2 | 23,716 | Gaylord Perry | Curt Simmons | Gaylord Perry | Curt Simmons | | 216 | 178 | 38 |
| 1965-06-01 | vs SLN | 47 | L 1-2 | 26-21 | 3 | 6,592 | Juan Marichal | Ray Sadecki | Ray Sadecki | Juan Marichal | | 217 | 180 | 37 |
| 1965-06-03 | @ MLN | 48 | L 3-10 | 26-22 | 4 | 3,336 | Bob Shaw | Ken Johnson | Ken Johnson | Bob Shaw | | 220 | 190 | 30 |
| 1965-06-04 | @ CIN | 49 | L 2-4 | 26-23 | 4 | 15,668 | Gaylord Perry | Joey Jay | Joey Jay | Gaylord Perry | Billy McCool | 222 | 194 | 28 |
| 1965-06-05 | @ CIN | 50 | W 1-0 | 27-23 | 4 | 25,262 | Juan Marichal | Jim Maloney | Juan Marichal | Jim Maloney | | 223 | 194 | 29 |
| 1965-06-06 | @ CIN | 51 | L 0-6 | 27-24 | 4 | 16,899 | Bill Hands | Sammy Ellis | Sammy Ellis | Bill Hands | | 223 | 200 | 23 |
| 1965-06-08 | @ NYN | 52 | W 2-1 | 28-24 | 4 | 34,659 | Bob Shaw | Galen Cisco | Bob Shaw | Galen Cisco | Frank Linzy | 225 | 201 | 24 |
| 1965-06-09 | @ NYN | 53 | W 4-2 | 29-24 | 4 | 37,660 | Gaylord Perry | Jack Fisher | Gaylord Perry | Jack Fisher | | 229 | 203 | 26 |
| 1965-06-10 | @ NYN | 54 | W 3-0 | 30-24 | 4 | 24,458 | Juan Marichal | Gary Kroll | Juan Marichal | Gary Kroll | | 232 | 203 | 29 |
| 1965-06-11 | @ PIT | 55 | L 3-5 | 30-25 | 4 | 24,708 | Bill Hands | Don Cardwell | Don Cardwell | Bill Hands | Frank Carpin | 235 | 208 | 27 |
| 1965-06-12 | @ PIT | 56 | W 4-0 | 31-25 | 4 | 12,213 | Bob Shaw | Bob Friend | Bob Shaw | Bob Friend | Frank Linzy | 239 | 208 | 31 |
| 1965-06-13 | @ PIT | 57 | L 1-2 | 31-26 | 4 | 20,091 | Gaylord Perry | Vern Law | Vern Law | Gaylord Perry | | 240 | 210 | 30 |
| 1965-06-15 | @ LAN | 58 | W 2-1 | 32-26 | 4 | 52,357 | Juan Marichal | Don Drysdale | Juan Marichal | Don Drysdale | | 242 | 211 | 31 |
| 1965-06-16 | @ LAN | 59 | L 1-2 | 32-27 | 4 | 44,499 | Bob Shaw | Sandy Koufax | Sandy Koufax | Bob Shaw | | 243 | 213 | 30 |
| 1965-06-17 | @ LAN | 60 | L 0-3 | 32-28 | 4 | 40,707 | Gaylord Perry | Claude Osteen | Claude Osteen | Gaylord Perry | | 243 | 216 | 27 |
| 1965-06-18 | vs NYN | 61 | W 3-0 | 33-28 | 4 | 12,788 | Jack Sanford | Galen Cisco | Jack Sanford | Galen Cisco | Frank Linzy | 246 | 216 | 30 |
| 1965-06-19 | vs NYN | 62 | W 2-1 | 34-28 | 4 | 17,069 | Juan Marichal | Jack Fisher | Juan Marichal | Jack Fisher | | 248 | 217 | 31 |
| 1965-06-20 | vs PIT | 63 | W 4-3 | 36-28 | 4 | 0 | Bob Shaw | Bob Friend | Ron Herbel | Al McBean | | 252 | 220 | 32 |
| 1965-06-20 | vs PIT | 64 | W 7-3 | 36-28 | 4 | 39,757 | Bobby Bolin | Don Schwall | Bobby Bolin | Don Schwall | Frank Linzy | 259 | 223 | 36 |
| 1965-06-22 | vs PIT | 65 | L 0-6 | 36-29 | 4 | 10,537 | Gaylord Perry | Vern Law | Vern Law | Gaylord Perry | | 259 | 229 | 30 |
| 1965-06-23 | vs PIT | 66 | W 6-1 | 37-29 | 4 | 8,209 | Jack Sanford | Bob Veale | Ron Herbel | Bob Veale | Frank Linzy | 265 | 230 | 35 |
| 1965-06-24 | vs PHI | 67 | L 1-3 | 37-30 | 4 | 8,738 | Juan Marichal | Jim Bunning | Jim Bunning | Juan Marichal | Ray Herbert | 266 | 233 | 33 |
| 1965-06-25 | vs PHI | 68 | W 4-1 | 38-30 | 4 | 12,948 | Bob Shaw | Bo Belinsky | Bob Shaw | Bo Belinsky | | 270 | 234 | 36 |
| 1965-06-26 | vs PHI | 69 | W 6-5 | 39-30 | 4 | 18,247 | Gaylord Perry | Chris Short | Masanori Murakami | Gary Wagner | | 276 | 239 | 37 |
| 1965-06-27 | vs PHI | 70 | L 0-6 | 39-31 | 4 | 27,015 | Bobby Bolin | Ray Culp | Ray Culp | Bobby Bolin | | 276 | 245 | 31 |
| 1965-06-28 | vs LAN | 71 | W 5-0 | 40-31 | 3 | 36,702 | Juan Marichal | Don Drysdale | Juan Marichal | Don Drysdale | | 281 | 245 | 36 |
| 1965-06-29 | vs LAN | 72 | L 3-9 | 40-32 | 4 | 29,380 | Bob Shaw | Sandy Koufax | Sandy Koufax | Bob Shaw | | 284 | 254 | 30 |
| 1965-06-30 | @ HOU | 73 | L 4-6 | 40-33 | 3 | 38,823 | Gaylord Perry | Turk Farrell | Claude Raymond | Frank Linzy | | 288 | 260 | 28 |
| 1965-07-02 | @ CHN | 74 | W 4-0 | 41-33 | 3 | 5,943 | Juan Marichal | Cal Koonce | Juan Marichal | Cal Koonce | | 292 | 260 | 32 |
| 1965-07-03 | @ CHN | 75 | L 1-4 | 41-34 | 3 | 16,287 | Bob Shaw | Larry Jackson | Larry Jackson | Bob Shaw | | 293 | 264 | 29 |
| 1965-07-04 | @ CHN | 76 | W 7-4 | 42-34 | 3 | 21,651 | Ron Herbel | Bob Buhl | Bobby Bolin | Lindy McDaniel | Frank Linzy | 300 | 268 | 32 |
| 1965-07-05 | @ SLN | 77 | L 2-3 | 42-35 | 3 | 20,324 | Gaylord Perry | Ray Washburn | Nelson Briles | Ron Herbel | | 302 | 271 | 31 |
| 1965-07-06 | @ SLN | 78 | L 2-3 | 42-36 | 3 | 31,229 | Juan Marichal | Curt Simmons | Curt Simmons | Juan Marichal | Hal Woodeshick | 304 | 274 | 30 |
| 1965-07-07 | @ SLN | 79 | W 4-2 | 43-36 | 3 | 24,045 | Bob Shaw | Bob Gibson | Masanori Murakami | Bob Gibson | | 308 | 276 | 32 |
| 1965-07-08 | @ PHI | 80 | W 10-2 | 44-37 | 4 | 0 | Gaylord Perry | Lew Burdette | Gaylord Perry | Lew Burdette | | 318 | 278 | 40 |
| 1965-07-08 | @ PHI | 81 | L 2-4 | 44-37 | 4 | 37,110 | Jack Sanford | Ray Herbert | Ray Herbert | Jack Sanford | | 320 | 282 | 38 |
| 1965-07-09 | @ PHI | 82 | L 2-10 | 44-38 | 4 | 27,954 | Jack Sanford | Jim Bunning | Jim Bunning | Jack Sanford | | 322 | 292 | 30 |
| 1965-07-10 | @ PHI | 83 | W 7-0 | 45-38 | 3 | 32,031 | Juan Marichal | Ray Culp | Juan Marichal | Ray Culp | | 329 | 292 | 37 |
| 1965-07-16 | vs HOU | 84 | W 2-1 | 46-38 | 3 | 13,240 | Bob Shaw | Bob Bruce | Bob Shaw | Bob Bruce | Ron Herbel | 331 | 293 | 38 |
| 1965-07-17 | vs HOU | 85 | W 7-0 | 47-38 | 3 | 15,771 | Juan Marichal | Turk Farrell | Juan Marichal | Turk Farrell | | 338 | 293 | 45 |
| 1965-07-18 | vs HOU | 86 | L 2-5 | 47-39 | 4 | 20,198 | Gaylord Perry | Claude Raymond | Claude Raymond | Gaylord Perry | Ron Taylor | 340 | 298 | 42 |
| 1965-07-19 | vs CHN | 87 | L 2-6 | 47-40 | 4 | 6,649 | Jack Sanford | Dick Ellsworth | Dick Ellsworth | Jack Sanford | Ted Abernathy | 342 | 304 | 38 |
| 1965-07-20 | vs CHN | 88 | W 2-0 | 48-40 | 4 | 6,975 | Bob Shaw | Larry Jackson | Bob Shaw | Larry Jackson | | 344 | 304 | 40 |
| 1965-07-21 | vs CIN | 89 | W 5-4 | 49-40 | 4 | 14,554 | Juan Marichal | John Tsitouris | Masanori Murakami | Roger Craig | | 349 | 308 | 41 |
| 1965-07-22 | vs CIN | 90 | L 4-5 | 49-41 | 4 | 17,696 | Warren Spahn | Jim Maloney | Jim Maloney | Frank Linzy | Billy McCool | 353 | 313 | 40 |
| 1965-07-23 | vs MLN | 91 | W 5-1 | 50-41 | 4 | 20,347 | Ron Herbel | Ken Johnson | Ron Herbel | Ken Johnson | Frank Linzy | 358 | 314 | 44 |
| 1965-07-24 | vs MLN | 92 | W 4-2 | 51-41 | 4 | 22,881 | Bob Shaw | Hank Fischer | Bobby Bolin | Hank Fischer | Frank Linzy | 362 | 316 | 46 |
| 1965-07-25 | vs MLN | 93 | W 2-1 | 52-41 | 3 | 33,120 | Bob Shaw | Bob Sadowski | Bob Shaw | Bob Sadowski | Frank Linzy | 364 | 317 | 47 |
| 1965-07-26 | vs SLN | 94 | L 4-7 | 52-42 | 4 | 13,869 | Juan Marichal | Bob Gibson | Bob Gibson | Juan Marichal | Don Dennis | 368 | 324 | 44 |
| 1965-07-27 | vs SLN | 95 | L 0-3 | 52-43 | 4 | 21,552 | Warren Spahn | Bob Purkey | Bob Purkey | Warren Spahn | | 368 | 327 | 41 |
| 1965-07-28 | vs SLN | 96 | W 8-5 | 53-43 | 4 | 12,711 | Ron Herbel | Tracy Stallard | Ron Herbel | Tracy Stallard | Frank Linzy | 376 | 332 | 44 |
| 1965-07-30 | @ MLN | 97 | W 9-2 | 54-43 | 4 | 6,787 | Bob Shaw | Hank Fischer | Bob Shaw | Hank Fischer | | 385 | 334 | 51 |
| 1965-07-31 | @ MLN | 98 | W 3-1 | 55-43 | 3 | 5,796 | Juan Marichal | Denny Lemaster | Juan Marichal | Denny Lemaster | | 388 | 335 | 53 |
| 1965-08-01 | @ MLN | 99 | L 2-4 | 55-45 | 4 | 0 | Ron Herbel | Tony Cloninger | Tony Cloninger | Ron Herbel | | 390 | 339 | 51 |
| 1965-08-01 | @ MLN | 100 | L 3-6 | 55-45 | 4 | 14,864 | Jack Sanford | Wade Blasingame | Wade Blasingame | Jack Sanford | Billy O'Dell | 393 | 345 | 48 |
| 1965-08-02 | @ MLN | 101 | L 2-4 | 55-46 | 4 | 6,293 | Gaylord Perry | Ken Johnson | Ken Johnson | Gaylord Perry | | 395 | 349 | 46 |
| 1965-08-03 | @ CIN | 102 | W 6-3 | 56-46 | 4 | 17,318 | Bob Shaw | Sammy Ellis | Frank Linzy | Bobby Locke | Bobby Bolin | 401 | 352 | 49 |
| 1965-08-04 | @ CIN | 103 | W 4-3 | 57-46 | 4 | 16,370 | Juan Marichal | Jim O'Toole | Juan Marichal | Ted Davidson | | 405 | 355 | 50 |
| 1965-08-05 | @ CIN | 104 | W 18-7 | 58-46 | 3 | 14,669 | Ron Herbel | John Tsitouris | Bobby Bolin | John Tsitouris | Masanori Murakami | 423 | 362 | 61 |
| 1965-08-06 | @ SLN | 105 | W 3-2 | 59-46 | 3 | 16,754 | Gaylord Perry | Ray Sadecki | Gaylord Perry | Ray Sadecki | Masanori Murakami | 426 | 364 | 62 |
| 1965-08-07 | @ SLN | 106 | W 10-4 | 60-46 | 2 | 18,737 | Bob Shaw | Tracy Stallard | Bob Shaw | Tracy Stallard | Frank Linzy | 436 | 368 | 68 |
| 1965-08-08 | @ SLN | 107 | W 6-4 | 61-46 | 3 | 21,983 | Warren Spahn | Curt Simmons | Warren Spahn | Curt Simmons | Jack Sanford | 442 | 372 | 70 |
| 1965-08-10 | vs PIT | 108 | W 4-3 | 62-46 | 3 | 14,457 | Juan Marichal | Don Cardwell | Juan Marichal | Don Cardwell | | 446 | 375 | 71 |
| 1965-08-12 | vs PIT | 109 | W 4-3 | 63-47 | 3 | 0 | Bob Shaw | Bob Friend | Frank Linzy | Don Schwall | | 450 | 378 | 72 |
| 1965-08-12 | vs PIT | 110 | L 2-5 | 63-47 | 3 | 20,435 | Gaylord Perry | Vern Law | Vern Law | Gaylord Perry | | 452 | 383 | 69 |
| 1965-08-13 | vs PHI | 111 | L 2-3 | 63-48 | 3 | 24,275 | Warren Spahn | Ray Herbert | Bo Belinsky | Warren Spahn | Gary Wagner | 454 | 386 | 68 |
| 1965-08-14 | vs PHI | 112 | L 2-4 | 63-49 | 3 | 23,087 | Juan Marichal | Jim Bunning | Jim Bunning | Juan Marichal | Jack Baldschun | 456 | 390 | 66 |
| 1965-08-15 | vs PHI | 113 | W 15-9 | 64-49 | 3 | 26,931 | Masanori Murakami | Ray Culp | Bill Henry | Ray Culp | Jack Sanford | 471 | 399 | 72 |
| 1965-08-16 | vs NYN | 114 | W 3-2 | 65-49 | 3 | 6,779 | Bob Shaw | Tom Parsons | Bob Shaw | Bob Moorhead | | 474 | 401 | 73 |
| 1965-08-17 | vs NYN | 115 | W 3-2 | 66-49 | 3 | 7,656 | Gaylord Perry | Jack Fisher | Bobby Bolin | Jack Fisher | | 477 | 403 | 74 |
| 1965-08-18 | vs NYN | 116 | W 5-0 | 67-49 | 3 | 8,841 | Juan Marichal | Larry Miller | Juan Marichal | Larry Miller | | 482 | 403 | 79 |
| 1965-08-19 | vs LAN | 117 | L 5-8 | 67-50 | 3 | 35,901 | Warren Spahn | Don Drysdale | Ron Perranoski | Gaylord Perry | | 487 | 411 | 76 |
| 1965-08-20 | vs LAN | 118 | W 5-1 | 68-50 | 3 | 41,858 | Bob Shaw | Howie Reed | Bob Shaw | Howie Reed | | 492 | 412 | 80 |
| 1965-08-21 | vs LAN | 119 | L 4-6 | 68-51 | 3 | 42,283 | Bobby Bolin | Claude Osteen | Johnny Podres | Bill Henry | | 496 | 418 | 78 |
| 1965-08-22 | vs LAN | 120 | W 4-3 | 69-51 | 3 | 42,807 | Juan Marichal | Sandy Koufax | Ron Herbel | Sandy Koufax | Masanori Murakami | 500 | 421 | 79 |
| 1965-08-23 | @ PIT | 121 | L 2-6 | 69-52 | 3 | 15,016 | Warren Spahn | Vern Law | Vern Law | Warren Spahn | | 502 | 427 | 75 |
| 1965-08-24 | @ PIT | 122 | L 2-5 | 69-53 | 3 | 15,497 | Bob Shaw | Don Cardwell | Don Cardwell | Bob Shaw | | 504 | 432 | 72 |
| 1965-08-25 | @ PIT | 123 | L 3-3 | 69-54 | 3 | 13,348 | Bobby Bolin | Bob Friend | | | | 507 | 435 | 72 |
| 1965-08-26 | @ PIT | 124 | L 0-8 | 69-56 | 4 | 0 | Ron Herbel | Bob Veale | Bob Veale | Ron Herbel | | 507 | 443 | 64 |
| 1965-08-26 | @ PIT | 125 | L 5-6 | 69-56 | 4 | 18,893 | Gaylord Perry | Tommie Sisk | Tommie Sisk | Gaylord Perry | Al McBean | 512 | 449 | 63 |
| 1965-08-27 | @ NYN | 126 | W 9-2 | 70-56 | 4 | 56,167 | Warren Spahn | Darrell Sutherland | Warren Spahn | Darrell Sutherland | Frank Linzy | 521 | 451 | 70 |
| 1965-08-28 | @ NYN | 127 | L 0-3 | 70-57 | 4 | 48,147 | Bob Shaw | Galen Cisco | Galen Cisco | Bob Shaw | Al Jackson | 521 | 454 | 67 |
| 1965-08-29 | @ NYN | 128 | W 8-3 | 71-57 | 4 | 46,033 | Bobby Bolin | Jack Fisher | Bobby Bolin | Jack Fisher | Masanori Murakami | 529 | 457 | 72 |
| 1965-08-31 | @ PHI | 129 | W 2-1 | 72-58 | 4 | 0 | Ron Herbel | Jim Bunning | Frank Linzy | Gary Wagner | | 531 | 458 | 73 |
| 1965-08-31 | @ PHI | 130 | L 0-2 | 72-58 | 4 | 33,060 | Warren Spahn | Lew Burdette | Lew Burdette | Warren Spahn | | 531 | 460 | 71 |
| 1965-09-02 | @ PHI | 131 | L 3-4 | 73-59 | 4 | 0 | Juan Marichal | Chris Short | Chris Short | Juan Marichal | | 534 | 464 | 70 |
| 1965-09-02 | @ PHI | 132 | W 5-2 | 73-59 | 4 | 30,410 | Bob Shaw | Ray Herbert | Frank Linzy | Jack Baldschun | | 539 | 466 | 73 |
| 1965-09-03 | @ CHN | 133 | L 4-5 | 73-60 | 4 | 6,986 | Bobby Bolin | Bill Faul | Bill Faul | Bobby Bolin | Ted Abernathy | 543 | 471 | 72 |
| 1965-09-04 | @ CHN | 134 | W 7-3 | 74-60 | 4 | 7,151 | Ron Herbel | Bob Buhl | Ron Herbel | Bob Buhl | Frank Linzy | 550 | 474 | 76 |
| 1965-09-05 | @ CHN | 135 | W 4-2 | 75-60 | 3 | 18,878 | Juan Marichal | Dick Ellsworth | Juan Marichal | Dick Ellsworth | | 554 | 476 | 78 |
| 1965-09-06 | @ LAN | 136 | W 7-6 | 76-60 | 3 | 53,581 | Warren Spahn | Don Drysdale | Frank Linzy | Howie Reed | | 561 | 482 | 79 |
| 1965-09-07 | @ LAN | 137 | W 3-1 | 77-60 | 2 | 48,586 | Bob Shaw | Claude Osteen | Bob Shaw | Claude Osteen | Masanori Murakami | 564 | 483 | 81 |
| 1965-09-08 | vs HOU | 138 | W 12-3 | 78-60 | 1 | 8,922 | Bobby Bolin | Don Nottebart | Bobby Bolin | Don Nottebart | | 576 | 486 | 90 |
| 1965-09-09 | vs HOU | 139 | W 4-0 | 79-60 | 1 | 20,076 | Juan Marichal | Bob Bruce | Juan Marichal | Bob Bruce | | 580 | 486 | 94 |
| 1965-09-10 | vs CHN | 140 | W 5-2 | 80-60 | 1 | 20,587 | Ron Herbel | Dick Ellsworth | Ron Herbel | Dick Ellsworth | Bill Henry | 585 | 488 | 97 |
| 1965-09-11 | vs CHN | 141 | W 6-4 | 81-60 | 1 | 21,217 | Bob Shaw | Bill Faul | Bob Shaw | Bill Faul | Gaylord Perry | 591 | 492 | 99 |
| 1965-09-12 | vs CHN | 142 | W 4-3 | 83-60 | 1 | 0 | Bobby Bolin | Larry Jackson | Bobby Bolin | Larry Jackson | Bill Henry | 595 | 495 | 100 |
| 1965-09-12 | vs CHN | 143 | W 9-2 | 83-60 | 1 | 41,070 | Warren Spahn | Bob Buhl | Warren Spahn | Bob Buhl | | 604 | 497 | 107 |
| 1965-09-13 | @ HOU | 144 | W 5-1 | 84-60 | 1 | 19,827 | Juan Marichal | Don Nottebart | Juan Marichal | Don Nottebart | | 609 | 498 | 111 |
| 1965-09-14 | @ HOU | 145 | W 7-5 | 85-60 | 1 | 15,415 | Ron Herbel | Bob Bruce | Bob Priddy | Jim Owens | Bobby Bolin | 616 | 503 | 113 |
| 1965-09-15 | @ HOU | 146 | W 3-2 | 86-60 | 1 | 19,176 | Bob Shaw | Robin Roberts | Frank Linzy | Dave Giusti | | 619 | 505 | 114 |
| 1965-09-16 | @ HOU | 147 | W 5-1 | 87-60 | 1 | 15,187 | Bobby Bolin | Turk Farrell | Bobby Bolin | Turk Farrell | | 624 | 506 | 118 |
| 1965-09-17 | @ MLN | 148 | L 1-9 | 87-61 | 1 | 6,924 | Juan Marichal | Phil Niekro | Phil Niekro | Juan Marichal | Billy O'Dell | 625 | 515 | 110 |
| 1965-09-18 | @ MLN | 149 | W 2-0 | 88-61 | 1 | 8,563 | Ron Herbel | Hank Fischer | Ron Herbel | Hank Fischer | Frank Linzy | 627 | 515 | 112 |
| 1965-09-19 | @ MLN | 150 | W 4-2 | 89-61 | 1 | 12,084 | Bob Shaw | Tony Cloninger | Bill Henry | Tony Cloninger | Juan Marichal | 631 | 517 | 114 |
| 1965-09-20 | @ CIN | 151 | W 4-0 | 90-61 | 1 | 14,070 | Bobby Bolin | Jim Maloney | Bobby Bolin | Jim Maloney | Masanori Murakami | 635 | 517 | 118 |
| 1965-09-21 | @ CIN | 152 | L 4-7 | 90-62 | 1 | 14,840 | Bob Shaw | Jim O'Toole | Ted Davidson | Frank Linzy | Billy McCool | 639 | 524 | 115 |
| 1965-09-22 | @ CIN | 153 | L 1-7 | 90-63 | 1 | 18,387 | Juan Marichal | Sammy Ellis | Sammy Ellis | Juan Marichal | | 640 | 531 | 109 |
| 1965-09-24 | vs MLN | 154 | L 2-8 | 90-64 | 1 | 28,995 | Ron Herbel | Tony Cloninger | Tony Cloninger | Ron Herbel | | 642 | 539 | 103 |
| 1965-09-25 | vs MLN | 155 | W 7-5 | 91-64 | 1 | 30,713 | Bob Shaw | Ken Johnson | Bobby Bolin | Ken Johnson | Frank Linzy | 649 | 544 | 105 |
| 1965-09-26 | vs MLN | 156 | L 2-3 | 91-65 | 2 | 39,783 | Juan Marichal | Hank Fischer | Hank Fischer | Juan Marichal | Dan Osinski | 651 | 547 | 104 |
| 1965-09-27 | vs SLN | 157 | W 8-4 | 92-65 | 2 | 8,280 | Warren Spahn | Tracy Stallard | Frank Linzy | Tracy Stallard | | 659 | 551 | 108 |
| 1965-09-28 | vs SLN | 158 | L 1-9 | 92-66 | 2 | 18,449 | Ron Herbel | Larry Jaster | Larry Jaster | Ron Herbel | | 660 | 560 | 100 |
| 1965-09-29 | vs SLN | 159 | L 6-8 | 92-67 | 2 | 10,345 | Bob Shaw | Bob Gibson | Bob Gibson | Bob Shaw | Hal Woodeshick | 666 | 568 | 98 |
| 1965-09-30 | vs CIN | 160 | W 5-3 | 93-67 | 2 | 14,502 | Juan Marichal | Joe Nuxhall | Masanori Murakami | Joe Nuxhall | | 671 | 571 | 100 |
| 1965-10-01 | vs CIN | 161 | L 2-17 | 93-68 | 2 | 29,220 | Bobby Bolin | Sammy Ellis | Sammy Ellis | Bobby Bolin | | 673 | 588 | 85 |
| 1965-10-02 | vs CIN | 162 | W 3-2 | 94-68 | 2 | 28,052 | Ron Herbel | Jim O'Toole | Ron Herbel | Jim O'Toole | Frank Linzy | 676 | 590 | 86 |
| 1965-10-03 | vs CIN | 163 | W 6-3 | 95-68 | 2 | 39,489 | Dick Estelle | Billy McCool | Bobby Bolin | Billy McCool | | 682 | 593 | 89 |