| 1965-04-12 | vs PHI | 1 | L 0-2 | - | | 42,652 | Bob Bruce | Chris Short | Chris Short | Bob Bruce | | 0 | 2 | -2 |
| 1965-04-14 | @ NYN | 2 | W 7-6 | - | | 7,277 | Turk Farrell | Warren Spahn | Turk Farrell | Larry Bearnarth | Jim Owens | 7 | 8 | -1 |
| 1965-04-15 | @ NYN | 3 | L 4-5 | - | | 7,894 | Ken Johnson | Jack Fisher | Jim Bethke | Claude Raymond | | 11 | 13 | -2 |
| 1965-04-17 | @ PIT | 4 | L 2-3 | - | | 6,129 | Don Nottebart | Bob Veale | Roy Face | Jim Owens | | 13 | 16 | -3 |
| 1965-04-18 | @ PIT | 5 | W 3-1 | - | | 0 | Bob Bruce | Vern Law | Bob Bruce | Vern Law | | 16 | 17 | -1 |
| 1965-04-18 | @ PIT | 6 | L 4-5 | - | | 7,176 | Don Larsen | Don Cardwell | Al McBean | Ken MacKenzie | | 20 | 22 | -2 |
| 1965-04-19 | @ PHI | 7 | L 0-8 | - | | 4,668 | Turk Farrell | Jim Bunning | Jim Bunning | Turk Farrell | | 20 | 30 | -10 |
| 1965-04-20 | @ PHI | 8 | L 1-2 | - | | 6,627 | Ken Johnson | Ray Herbert | Jack Baldschun | Hal Woodeshick | | 21 | 32 | -11 |
| 1965-04-21 | @ PHI | 9 | W 11-4 | - | | 8,267 | Don Nottebart | Chris Short | Dave Giusti | Chris Short | | 32 | 36 | -4 |
| 1965-04-23 | vs PIT | 10 | W 4-3 | - | | 25,399 | Bob Bruce | Bob Veale | Dave Giusti | Al McBean | | 36 | 39 | -3 |
| 1965-04-24 | vs PIT | 11 | W 5-0 | - | | 30,736 | Turk Farrell | Vern Law | Turk Farrell | Vern Law | | 41 | 39 | 2 |
| 1965-04-25 | vs PIT | 12 | W 5-4 | - | | 19,116 | Ken Johnson | Don Cardwell | Claude Raymond | Roy Face | | 46 | 43 | 3 |
| 1965-04-26 | vs PIT | 13 | W 2-0 | - | | 15,053 | Dave Giusti | Bob Friend | Dave Giusti | Bob Friend | | 48 | 43 | 5 |
| 1965-04-27 | vs NYN | 14 | W 3-2 | - | | 16,837 | Don Nottebart | Jack Fisher | Hal Woodeshick | Dennis Ribant | | 51 | 45 | 6 |
| 1965-04-28 | vs NYN | 15 | W 12-9 | - | | 27,690 | Bob Bruce | Frank Lary | Jim Owens | Tug McGraw | Claude Raymond | 63 | 54 | 9 |
| 1965-04-30 | vs CHN | 16 | W 4-3 | - | | 27,491 | Turk Farrell | Bob Buhl | Turk Farrell | Bob Buhl | Hal Woodeshick | 67 | 57 | 10 |
| 1965-05-01 | vs CHN | 17 | W 6-4 | - | | 13,048 | Ken Johnson | Lew Burdette | Ken Johnson | Lew Burdette | Claude Raymond | 73 | 61 | 12 |
| 1965-05-01 | vs CHN | 18 | W 6-1 | - | | 37,255 | Dave Giusti | Dick Ellsworth | Dave Giusti | Dick Ellsworth | | 79 | 62 | 17 |
| 1965-05-02 | vs CHN | 19 | L 3-6 | - | | 32,775 | Don Nottebart | Larry Jackson | Larry Jackson | Don Nottebart | Ted Abernathy | 82 | 68 | 14 |
| 1965-05-04 | @ MLN | 20 | L 3-9 | - | | 913 | Bob Bruce | Tony Cloninger | Tony Cloninger | Bob Bruce | | 85 | 77 | 8 |
| 1965-05-05 | @ MLN | 21 | L 1-2 | - | | 1,391 | Turk Farrell | Wade Blasingame | Wade Blasingame | Claude Raymond | | 86 | 79 | 7 |
| 1965-05-07 | @ CHN | 22 | W 5-4 | - | | 3,424 | Dave Giusti | Lew Burdette | Dave Giusti | Lew Burdette | Jim Owens | 91 | 83 | 8 |
| 1965-05-08 | @ CHN | 23 | W 11-6 | - | | 10,186 | Don Nottebart | Cal Koonce | Larry Dierker | Cal Koonce | | 102 | 89 | 13 |
| 1965-05-09 | @ CHN | 24 | W 11-5 | - | | 0 | Ken Johnson | Bob Buhl | Ken Johnson | Bob Buhl | Jim Owens | 113 | 94 | 19 |
| 1965-05-09 | @ CHN | 25 | L 1-7 | - | | 17,796 | Bob Bruce | Dick Ellsworth | Dick Ellsworth | Bob Bruce | Ted Abernathy | 114 | 101 | 13 |
| 1965-05-10 | @ LAN | 26 | L 2-3 | - | | 22,535 | Danny Coombs | Johnny Podres | Bob Miller | Hal Woodeshick | | 116 | 104 | 12 |
| 1965-05-11 | @ LAN | 27 | W 2-1 | - | | 21,086 | Dave Giusti | Claude Osteen | Dave Giusti | Claude Osteen | | 118 | 105 | 13 |
| 1965-05-12 | @ LAN | 28 | L 2-4 | - | | 19,302 | Don Nottebart | Don Drysdale | Don Drysdale | Don Nottebart | | 120 | 109 | 11 |
| 1965-05-13 | @ LAN | 29 | L 0-3 | - | | 20,963 | Bob Bruce | Sandy Koufax | Sandy Koufax | Bob Bruce | | 120 | 112 | 8 |
| 1965-05-14 | @ SFN | 30 | L 1-2 | - | | 11,900 | Ken Johnson | Gaylord Perry | Gaylord Perry | Ken Johnson | | 121 | 114 | 7 |
| 1965-05-15 | @ SFN | 31 | L 2-8 | - | | 13,177 | Larry Dierker | Ron Herbel | Bobby Bolin | Larry Dierker | | 123 | 122 | 1 |
| 1965-05-16 | @ SFN | 32 | L 5-10 | - | | 0 | Dave Giusti | Juan Marichal | Juan Marichal | Dave Giusti | | 128 | 132 | -4 |
| 1965-05-16 | @ SFN | 33 | L 3-4 | - | | 33,368 | Don Nottebart | Bob Shaw | Bob Shaw | Don Nottebart | Masanori Murakami | 131 | 136 | -5 |
| 1965-05-17 | vs LAN | 34 | L 3-5 | - | | 40,858 | Bob Bruce | Sandy Koufax | Sandy Koufax | Bob Bruce | Bob Miller | 134 | 141 | -7 |
| 1965-05-18 | vs LAN | 35 | W 4-1 | - | | 22,220 | Ken Johnson | Jim Brewer | Ken Johnson | Jim Brewer | Hal Woodeshick | 138 | 142 | -4 |
| 1965-05-19 | vs LAN | 36 | L 2-4 | - | | 30,885 | Dave Giusti | Claude Osteen | John Purdin | Ken MacKenzie | Don Drysdale | 140 | 146 | -6 |
| 1965-05-21 | vs SFN | 37 | L 1-8 | - | | 33,094 | Don Nottebart | Ron Herbel | Ron Herbel | Don Nottebart | | 141 | 154 | -13 |
| 1965-05-22 | vs SFN | 38 | L 1-10 | - | | 22,560 | Bob Bruce | Juan Marichal | Juan Marichal | Bob Bruce | | 142 | 164 | -22 |
| 1965-05-22 | vs SFN | 39 | W 3-2 | - | | 43,367 | Turk Farrell | Jack Sanford | Hal Woodeshick | Masanori Murakami | | 145 | 166 | -21 |
| 1965-05-23 | vs SFN | 40 | L 2-5 | - | | 31,493 | Ken Johnson | Gaylord Perry | Gaylord Perry | Ken Johnson | Bill Henry | 147 | 171 | -24 |
| 1965-05-24 | vs CIN | 41 | L 2-5 | - | | 15,496 | Dave Giusti | Jim Maloney | Jim Maloney | Dave Giusti | Joey Jay | 149 | 176 | -27 |
| 1965-05-25 | vs CIN | 42 | L 4-7 | - | | 15,148 | Don Nottebart | Sammy Ellis | Sammy Ellis | Jim Owens | | 153 | 183 | -30 |
| 1965-05-26 | vs CIN | 43 | W 8-3 | - | | 9,247 | Bob Bruce | Billy McCool | Bob Bruce | Billy McCool | | 161 | 186 | -25 |
| 1965-05-27 | vs SLN | 44 | W 6-1 | - | | 22,430 | Turk Farrell | Ray Washburn | Turk Farrell | Ray Washburn | | 167 | 187 | -20 |
| 1965-05-28 | vs SLN | 45 | W 3-2 | - | | 31,190 | Dave Giusti | Ray Sadecki | Jim Owens | Ron Taylor | | 170 | 189 | -19 |
| 1965-05-29 | vs SLN | 46 | W 4-3 | - | | 35,553 | Don Nottebart | Tracy Stallard | Hal Woodeshick | Bob Purkey | | 174 | 192 | -18 |
| 1965-05-30 | vs MLN | 47 | L 5-6 | - | | 38,734 | Larry Dierker | Wade Blasingame | Wade Blasingame | Larry Dierker | Billy O'Dell | 179 | 198 | -19 |
| 1965-05-31 | vs MLN | 48 | W 7-2 | - | | 25,120 | Bob Bruce | Tony Cloninger | Bob Bruce | Tony Cloninger | | 186 | 200 | -14 |
| 1965-06-01 | vs MLN | 49 | L 1-2 | - | | 28,692 | Turk Farrell | Denny Lemaster | Billy O'Dell | Hal Woodeshick | | 187 | 202 | -15 |
| 1965-06-02 | @ CIN | 50 | L 2-5 | - | | 5,592 | Dave Giusti | Sammy Ellis | Sammy Ellis | Dave Giusti | | 189 | 207 | -18 |
| 1965-06-03 | @ CIN | 51 | W 8-3 | - | | 4,393 | Don Nottebart | Gerry Arrigo | Don Nottebart | Gerry Arrigo | Hal Woodeshick | 197 | 210 | -13 |
| 1965-06-04 | @ SLN | 52 | W 5-2 | - | | 24,640 | Bob Bruce | Bob Gibson | Bob Bruce | Bob Gibson | Jim Owens | 202 | 212 | -10 |
| 1965-06-05 | @ SLN | 53 | L 3-4 | - | | 8,862 | Larry Dierker | Curt Simmons | Ray Washburn | Ken MacKenzie | | 205 | 216 | -11 |
| 1965-06-06 | @ SLN | 54 | W 10-1 | - | | 20,878 | Claude Raymond | Ray Sadecki | Claude Raymond | Ray Sadecki | | 215 | 217 | -2 |
| 1965-06-08 | @ PIT | 55 | L 6-7 | - | | 8,084 | Turk Farrell | Bob Friend | Joe Gibbon | Hal Woodeshick | | 221 | 224 | -3 |
| 1965-06-09 | @ PIT | 56 | L 3-11 | - | | 9,412 | Don Nottebart | Vern Law | Vern Law | Don Nottebart | | 224 | 235 | -11 |
| 1965-06-10 | @ PIT | 57 | L 2-4 | - | | 9,839 | Bob Bruce | Bob Veale | Bob Veale | Bob Bruce | | 226 | 239 | -13 |
| 1965-06-11 | @ PHI | 58 | L 5-6 | - | | 16,825 | Dave Giusti | Ray Culp | Gary Wagner | Jim Owens | | 231 | 245 | -14 |
| 1965-06-12 | @ PHI | 59 | L 4-5 | - | | 7,870 | Turk Farrell | Jim Bunning | Ed Roebuck | Turk Farrell | | 235 | 250 | -15 |
| 1965-06-13 | @ PHI | 60 | L 0-5 | - | | 12,936 | Claude Raymond | Chris Short | Chris Short | Claude Raymond | | 235 | 255 | -20 |
| 1965-06-14 | vs CHN | 61 | L 0-2 | - | | 26,761 | Bob Bruce | Larry Jackson | Larry Jackson | Bob Bruce | | 235 | 257 | -22 |
| 1965-06-15 | vs CHN | 62 | L 0-5 | - | | 19,167 | Larry Dierker | Bob Buhl | Bob Buhl | Larry Dierker | Ted Abernathy | 235 | 262 | -27 |
| 1965-06-16 | vs CHN | 63 | W 3-2 | - | | 21,835 | Turk Farrell | Dick Ellsworth | Jim Owens | Lindy McDaniel | | 238 | 264 | -26 |
| 1965-06-17 | vs CHN | 64 | L 5-6 | - | | 16,616 | Dave Giusti | Bob Hendley | Ernie Broglio | Jim Owens | Ted Abernathy | 243 | 270 | -27 |
| 1965-06-18 | vs PIT | 65 | W 5-1 | - | | 24,286 | Bob Bruce | Bob Veale | Bob Bruce | Bob Veale | | 248 | 271 | -23 |
| 1965-06-19 | vs PIT | 66 | L 3-5 | - | | 27,785 | Claude Raymond | Don Cardwell | Joe Gibbon | Don Nottebart | Frank Carpin | 251 | 276 | -25 |
| 1965-06-20 | vs PHI | 67 | L 2-3 | - | | 0 | Larry Dierker | Jim Bunning | Jim Bunning | Ron Taylor | Gary Wagner | 253 | 279 | -26 |
| 1965-06-20 | vs PHI | 68 | L 1-7 | - | | 42,648 | Mike Cuellar | Bo Belinsky | Bo Belinsky | Mike Cuellar | | 254 | 286 | -32 |
| 1965-06-21 | vs PHI | 69 | W 6-2 | - | | 18,271 | Turk Farrell | Ray Culp | Turk Farrell | Ray Culp | | 260 | 288 | -28 |
| 1965-06-22 | vs PHI | 70 | L 2-7 | - | | 19,331 | Bob Bruce | Chris Short | Chris Short | Bob Bruce | Gary Wagner | 262 | 295 | -33 |
| 1965-06-24 | vs NYN | 71 | W 4-2 | - | | 22,329 | Claude Raymond | Jack Fisher | Claude Raymond | Jack Fisher | Jim Owens | 266 | 297 | -31 |
| 1965-06-25 | vs NYN | 72 | W 6-2 | - | | 27,161 | Larry Dierker | Warren Spahn | Larry Dierker | Warren Spahn | Dave Giusti | 272 | 299 | -27 |
| 1965-06-26 | vs NYN | 73 | W 2-0 | - | | 33,500 | Turk Farrell | Frank Lary | Turk Farrell | Frank Lary | | 274 | 299 | -25 |
| 1965-06-27 | vs NYN | 74 | W 4-2 | - | | 25,224 | Bob Bruce | Al Jackson | Bob Bruce | Al Jackson | Mike Cuellar | 278 | 301 | -23 |
| 1965-06-28 | @ CHN | 75 | L 2-7 | - | | 4,464 | Dave Giusti | Larry Jackson | Larry Jackson | Dave Giusti | | 280 | 308 | -28 |
| 1965-06-30 | vs SFN | 76 | W 6-4 | - | | 38,823 | Turk Farrell | Gaylord Perry | Claude Raymond | Frank Linzy | | 286 | 312 | -26 |
| 1965-07-02 | vs LAN | 77 | W 4-3 | - | | 33,044 | Bob Bruce | Don Drysdale | Mike Cuellar | Don Drysdale | | 290 | 315 | -25 |
| 1965-07-03 | vs LAN | 78 | L 1-3 | - | | 50,136 | Larry Dierker | Sandy Koufax | Sandy Koufax | Larry Dierker | | 291 | 318 | -27 |
| 1965-07-04 | vs LAN | 79 | W 3-1 | - | | 47,642 | Claude Raymond | Claude Osteen | Claude Raymond | Claude Osteen | | 294 | 319 | -25 |
| 1965-07-05 | @ MLN | 80 | W 5-4 | - | | 7,775 | Turk Farrell | Wade Blasingame | Jim Owens | Bob Sadowski | Mike Cuellar | 299 | 323 | -24 |
| 1965-07-07 | @ MLN | 81 | L 2-5 | - | | 4,840 | Bob Bruce | Ken Johnson | Ken Johnson | Bob Bruce | Billy O'Dell | 301 | 328 | -27 |
| 1965-07-08 | @ MLN | 82 | L 8-9 | - | | 2,522 | Don Nottebart | Tony Cloninger | Wade Blasingame | Ron Taylor | | 309 | 337 | -28 |
| 1965-07-09 | @ NYN | 83 | W 6-2 | - | | 29,645 | Larry Dierker | Jack Fisher | Larry Dierker | Jack Fisher | Ron Taylor | 315 | 339 | -24 |
| 1965-07-10 | @ NYN | 84 | W 10-1 | - | | 13,837 | Turk Farrell | Warren Spahn | Turk Farrell | Warren Spahn | Ron Taylor | 325 | 340 | -15 |
| 1965-07-16 | @ SFN | 85 | L 1-2 | - | | 13,240 | Bob Bruce | Bob Shaw | Bob Shaw | Bob Bruce | Ron Herbel | 326 | 342 | -16 |
| 1965-07-17 | @ SFN | 86 | L 0-7 | - | | 15,771 | Turk Farrell | Juan Marichal | Juan Marichal | Turk Farrell | | 326 | 349 | -23 |
| 1965-07-18 | @ SFN | 87 | W 5-2 | - | | 20,198 | Claude Raymond | Gaylord Perry | Claude Raymond | Gaylord Perry | Ron Taylor | 331 | 351 | -20 |
| 1965-07-19 | @ LAN | 88 | L 3-8 | - | | 22,756 | Don Nottebart | Don Drysdale | Don Drysdale | Don Nottebart | | 334 | 359 | -25 |
| 1965-07-20 | @ LAN | 89 | L 2-3 | - | | 30,937 | Mike Cuellar | Sandy Koufax | Sandy Koufax | Ron Taylor | | 336 | 362 | -26 |
| 1965-07-21 | vs SLN | 90 | W 2-0 | - | | 43,324 | Bob Bruce | Bob Gibson | Bob Bruce | Bob Gibson | | 338 | 362 | -24 |
| 1965-07-22 | vs SLN | 91 | W 3-2 | - | | 30,668 | Larry Dierker | Bob Purkey | Larry Dierker | Bob Purkey | | 341 | 364 | -23 |
| 1965-07-23 | vs CIN | 92 | L 1-9 | - | | 31,595 | Claude Raymond | Joey Jay | Joey Jay | Claude Raymond | | 342 | 373 | -31 |
| 1965-07-24 | vs CIN | 93 | W 4-2 | - | | 30,738 | Don Nottebart | Sammy Ellis | Don Nottebart | Sammy Ellis | | 346 | 375 | -29 |
| 1965-07-24 | vs CIN | 94 | L 0-2 | - | | 42,595 | Turk Farrell | Joe Nuxhall | Joe Nuxhall | Turk Farrell | | 346 | 377 | -31 |
| 1965-07-25 | vs CIN | 95 | L 1-3 | - | | 36,515 | Mike Cuellar | John Tsitouris | John Tsitouris | Mike Cuellar | Billy McCool | 347 | 380 | -33 |
| 1965-07-26 | vs MLN | 96 | L 0-6 | - | | 24,395 | Bob Bruce | Wade Blasingame | Wade Blasingame | Bob Bruce | | 347 | 386 | -39 |
| 1965-07-27 | vs MLN | 97 | L 1-7 | - | | 23,642 | Larry Dierker | Tony Cloninger | Tony Cloninger | Larry Dierker | Billy O'Dell | 348 | 393 | -45 |
| 1965-07-28 | vs MLN | 98 | L 4-6 | - | | 32,772 | Turk Farrell | Ken Johnson | Ken Johnson | Turk Farrell | Billy O'Dell | 352 | 399 | -47 |
| 1965-07-30 | @ CIN | 99 | L 1-7 | - | | 18,646 | Don Nottebart | Joe Nuxhall | Joe Nuxhall | Don Nottebart | | 353 | 406 | -53 |
| 1965-07-31 | @ CIN | 100 | L 4-11 | - | | 6,778 | Bob Bruce | Jim Maloney | Jim Maloney | Bob Bruce | Sammy Ellis | 357 | 417 | -60 |
| 1965-08-01 | @ CIN | 101 | L 4-6 | - | | 0 | Mike Cuellar | Joey Jay | Ted Davidson | Mike Cuellar | Billy McCool | 361 | 423 | -62 |
| 1965-08-01 | @ CIN | 102 | W 7-6 | - | | 16,286 | Dave Giusti | John Tsitouris | Jim Owens | Billy McCool | Turk Farrell | 368 | 429 | -61 |
| 1965-08-03 | @ SLN | 103 | W 10-7 | - | | 0 | Larry Dierker | Bob Purkey | Larry Dierker | Bob Purkey | Ron Taylor | 378 | 436 | -58 |
| 1965-08-03 | @ SLN | 104 | L 0-7 | - | | 17,818 | Turk Farrell | Ray Washburn | Ray Washburn | Turk Farrell | | 378 | 443 | -65 |
| 1965-08-04 | @ SLN | 105 | L 4-9 | - | | 12,066 | Don Nottebart | Curt Simmons | Curt Simmons | Don Nottebart | | 382 | 452 | -70 |
| 1965-08-05 | @ SLN | 106 | L 1-3 | - | | 11,334 | Bob Bruce | Bob Gibson | Bob Gibson | Bob Bruce | | 383 | 455 | -72 |
| 1965-08-06 | @ MLN | 107 | L 4-8 | - | | 2,805 | Ron Taylor | Tony Cloninger | Tony Cloninger | Ron Taylor | | 387 | 463 | -76 |
| 1965-08-07 | @ MLN | 108 | W 4-0 | - | | 3,778 | Turk Farrell | Ken Johnson | Turk Farrell | Ken Johnson | | 391 | 463 | -72 |
| 1965-08-08 | @ MLN | 109 | L 5-8 | - | | 0 | Don Nottebart | Wade Blasingame | Wade Blasingame | Don Nottebart | Billy O'Dell | 396 | 471 | -75 |
| 1965-08-08 | @ MLN | 110 | L 3-8 | - | | 20,882 | Larry Dierker | Denny Lemaster | Billy O'Dell | Larry Dierker | | 399 | 479 | -80 |
| 1965-08-09 | vs PHI | 111 | W 8-0 | - | | 31,209 | Robin Roberts | Lew Burdette | Robin Roberts | Lew Burdette | | 407 | 479 | -72 |
| 1965-08-10 | vs PHI | 112 | L 0-2 | - | | 24,533 | Bob Bruce | Jim Bunning | Jim Bunning | Bob Bruce | | 407 | 481 | -74 |
| 1965-08-11 | vs PHI | 113 | L 1-5 | - | | 28,224 | Danny Coombs | Ray Culp | Ray Culp | Danny Coombs | | 408 | 486 | -78 |
| 1965-08-12 | vs PHI | 114 | L 3-7 | - | | 22,011 | Turk Farrell | Chris Short | Chris Short | Turk Farrell | Ed Roebuck | 411 | 493 | -82 |
| 1965-08-13 | vs NYN | 115 | W 3-2 | - | | 27,978 | Don Nottebart | Jack Fisher | Don Nottebart | Jack Fisher | | 414 | 495 | -81 |
| 1965-08-14 | vs NYN | 116 | L 0-1 | - | | 41,732 | Larry Dierker | Galen Cisco | Darrell Sutherland | Dave Giusti | | 414 | 496 | -82 |
| 1965-08-15 | vs NYN | 117 | L 0-3 | - | | 33,952 | Bob Bruce | Al Jackson | Al Jackson | Bob Bruce | | 414 | 499 | -85 |
| 1965-08-16 | vs PIT | 118 | W 3-0 | - | | 26,549 | Robin Roberts | Bob Friend | Robin Roberts | Bob Friend | | 417 | 499 | -82 |
| 1965-08-17 | vs PIT | 119 | L 6-8 | - | | 24,863 | Turk Farrell | Vern Law | Vern Law | Turk Farrell | Al McBean | 423 | 507 | -84 |
| 1965-08-18 | vs PIT | 120 | L 7-8 | - | | 30,470 | Don Nottebart | Bob Veale | Bob Veale | Don Nottebart | Al McBean | 430 | 515 | -85 |
| 1965-08-20 | @ CHN | 121 | W 7-4 | - | | 0 | Bob Bruce | Bob Buhl | Bob Bruce | Ted Abernathy | | 437 | 519 | -82 |
| 1965-08-20 | @ CHN | 122 | L 0-2 | - | | 7,936 | Larry Dierker | Bill Faul | Bill Faul | Larry Dierker | | 437 | 521 | -84 |
| 1965-08-21 | @ CHN | 123 | W 9-2 | - | | 6,362 | Robin Roberts | Dick Ellsworth | Robin Roberts | Dick Ellsworth | | 446 | 523 | -77 |
| 1965-08-22 | @ CHN | 124 | L 1-3 | - | | 9,106 | Turk Farrell | Billy Hoeft | Billy Hoeft | Turk Farrell | | 447 | 526 | -79 |
| 1965-08-24 | @ PHI | 125 | W 4-3 | - | | 13,863 | Don Nottebart | Chris Short | Don Nottebart | Gary Wagner | | 451 | 529 | -78 |
| 1965-08-25 | @ PHI | 126 | W 7-6 | - | | 11,066 | Bob Bruce | Ray Culp | Ron Taylor | Jack Baldschun | Jim Owens | 458 | 535 | -77 |
| 1965-08-26 | @ PHI | 127 | W 6-4 | - | | 21,805 | Robin Roberts | Jim Bunning | Dave Giusti | Gary Wagner | Jim Owens | 464 | 539 | -75 |
| 1965-08-27 | @ PIT | 128 | L 9-10 | - | | 12,917 | Turk Farrell | Vern Law | Al McBean | Mike Cuellar | | 473 | 549 | -76 |
| 1965-08-28 | @ PIT | 129 | W 9-6 | - | | 7,051 | Larry Dierker | Don Cardwell | Larry Dierker | Don Schwall | Dave Giusti | 482 | 555 | -73 |
| 1965-08-29 | @ PIT | 130 | L 2-4 | - | | 30,002 | Don Nottebart | Bob Friend | Wilbur Wood | Don Nottebart | Joe Gibbon | 484 | 559 | -75 |
| 1965-08-31 | @ NYN | 131 | W 4-3 | - | | 0 | Robin Roberts | Larry Miller | Robin Roberts | Larry Miller | Jim Owens | 488 | 562 | -74 |
| 1965-08-31 | @ NYN | 132 | W 3-2 | - | | 25,562 | Bob Bruce | Tug McGraw | Bob Bruce | Tug McGraw | | 491 | 564 | -73 |
| 1965-09-01 | @ NYN | 133 | L 1-4 | - | | 0 | Danny Coombs | Al Jackson | Al Jackson | Danny Coombs | | 492 | 568 | -76 |
| 1965-09-01 | @ NYN | 134 | W 8-5 | - | | 13,880 | Turk Farrell | Rob Gardner | Turk Farrell | Rob Gardner | Dave Giusti | 500 | 573 | -73 |
| 1965-09-02 | @ NYN | 135 | W 4-3 | - | | 11,430 | Larry Dierker | Jack Fisher | Larry Dierker | Jack Fisher | Claude Raymond | 504 | 576 | -72 |
| 1965-09-03 | vs LAN | 136 | L 0-3 | - | | 31,154 | Don Nottebart | Nick Willhite | Nick Willhite | Don Nottebart | Ron Perranoski | 504 | 579 | -75 |
| 1965-09-04 | vs LAN | 137 | L 0-5 | - | | 41,951 | Bob Bruce | Jim Brewer | Johnny Podres | Bob Bruce | Ron Perranoski | 504 | 584 | -80 |
| 1965-09-05 | vs LAN | 138 | L 2-4 | - | | 49,442 | Robin Roberts | Sandy Koufax | Howie Reed | Robin Roberts | | 506 | 588 | -82 |
| 1965-09-06 | vs CHN | 139 | W 2-1 | - | | 31,814 | Turk Farrell | Larry Jackson | Turk Farrell | Larry Jackson | | 508 | 589 | -81 |
| 1965-09-08 | @ SFN | 140 | L 3-12 | - | | 8,922 | Don Nottebart | Bobby Bolin | Bobby Bolin | Don Nottebart | | 511 | 601 | -90 |
| 1965-09-09 | @ SFN | 141 | L 0-4 | - | | 20,076 | Bob Bruce | Juan Marichal | Juan Marichal | Bob Bruce | | 511 | 605 | -94 |
| 1965-09-10 | @ LAN | 142 | L 2-5 | - | | 30,200 | Robin Roberts | Don Drysdale | Don Drysdale | Robin Roberts | Ron Perranoski | 513 | 610 | -97 |
| 1965-09-11 | @ LAN | 143 | L 3-8 | - | | 30,278 | Turk Farrell | Claude Osteen | Claude Osteen | Turk Farrell | Ron Perranoski | 516 | 618 | -102 |
| 1965-09-12 | @ LAN | 144 | W 3-2 | - | | 21,918 | Larry Dierker | Johnny Podres | Jim Owens | Ron Perranoski | Claude Raymond | 519 | 620 | -101 |
| 1965-09-13 | vs SFN | 145 | L 1-5 | - | | 19,827 | Don Nottebart | Juan Marichal | Juan Marichal | Don Nottebart | | 520 | 625 | -105 |
| 1965-09-14 | vs SFN | 146 | L 5-7 | - | | 15,415 | Bob Bruce | Ron Herbel | Bob Priddy | Jim Owens | Bobby Bolin | 525 | 632 | -107 |
| 1965-09-15 | vs SFN | 147 | L 2-3 | - | | 19,176 | Robin Roberts | Bob Shaw | Frank Linzy | Dave Giusti | | 527 | 635 | -108 |
| 1965-09-16 | vs SFN | 148 | L 1-5 | - | | 15,187 | Turk Farrell | Bobby Bolin | Bobby Bolin | Turk Farrell | | 528 | 640 | -112 |
| 1965-09-17 | @ CIN | 149 | L 2-4 | - | | 10,431 | Larry Dierker | Sammy Ellis | Sammy Ellis | Larry Dierker | Billy McCool | 530 | 644 | -114 |
| 1965-09-19 | @ CIN | 150 | W 8-6 | - | | 0 | Bob Bruce | Joey Jay | Claude Raymond | Ted Davidson | | 538 | 650 | -112 |
| 1965-09-19 | @ CIN | 151 | L 3-4 | - | | 19,907 | Jack Lamabe | Joe Nuxhall | Joe Nuxhall | Jack Lamabe | Billy McCool | 541 | 654 | -113 |
| 1965-09-21 | @ SLN | 152 | L 0-3 | - | | 4,348 | Chris Zachary | Ray Sadecki | Ray Sadecki | Chris Zachary | Hal Woodeshick | 541 | 657 | -116 |
| 1965-09-22 | @ SLN | 153 | L 1-4 | - | | 5,896 | Jim Ray | Larry Jaster | Larry Jaster | Jim Ray | | 542 | 661 | -119 |
| 1965-09-25 | vs CIN | 154 | L 0-1 | - | | 24,443 | Robin Roberts | Jim Maloney | Jim Maloney | Dave Giusti | | 542 | 662 | -120 |
| 1965-09-26 | vs CIN | 155 | W 4-2 | - | | 15,540 | Bob Bruce | Joe Nuxhall | Turk Farrell | Billy McCool | | 546 | 664 | -118 |
| 1965-09-27 | vs MLN | 156 | W 4-3 | - | | 8,380 | Larry Dierker | Wade Blasingame | Dave Giusti | Dan Osinski | | 550 | 667 | -117 |
| 1965-09-28 | vs MLN | 157 | L 1-7 | - | | 9,809 | Chris Zachary | Tony Cloninger | Tony Cloninger | Chris Zachary | | 551 | 674 | -123 |
| 1965-09-29 | vs MLN | 158 | L 1-5 | - | | 8,895 | Jack Lamabe | Ken Johnson | Ken Johnson | Jack Lamabe | | 552 | 679 | -127 |
| 1965-09-30 | vs SLN | 159 | L 8-19 | - | | 7,494 | Jim Ray | Nelson Briles | Nelson Briles | Jim Ray | Dennis Aust | 560 | 698 | -138 |
| 1965-10-01 | vs SLN | 160 | W 4-2 | - | | 10,247 | Robin Roberts | Ray Sadecki | Robin Roberts | Ray Sadecki | Claude Raymond | 564 | 700 | -136 |
| 1965-10-02 | vs SLN | 161 | L 3-6 | - | | 12,698 | Don Arlich | Larry Jaster | Larry Jaster | Ron Taylor | | 567 | 706 | -139 |
| 1965-10-03 | vs SLN | 162 | L 2-5 | - | | 13,535 | Carroll Sembera | Bob Gibson | Bob Gibson | Carroll Sembera | | 569 | 711 | -142 |