| 26 | Billy Williams | of | 5 | 26 | UDFA: 1956 | MLB | 162 | 709 | 465 | 135 | 7.9 | .316 | -.216 | .220 | 0.70 | 4.7 | 127 | 74 | 36.8 | 8.3 | 11.8 | 0.99 | 0.3 | 190 | 130 | 60 | 28 |
| 10 | Ron Santo | 3b | 2 | 24 | UDFA: 1959 | MLB | 161 | 686 | 428 | 142 | 9.0 | .328 | -.169 | .252 | 0.90 | 4.4 | 109 | 76 | 41.1 | 12.5 | 14.0 | 0.84 | 0.3 | 197 | 115 | 82 | 21 |
| 14 | Ernie Banks | 1b-ss | 25 | 33 | UDFA: 1953 | MLB | 157 | 637 | 460 | 87 | 5.1 | .271 | -.205 | .186 | 0.43 | 3.6 | 98 | 58 | 37.2 | 5.7 | 13.2 | 0.70 | 0.2 | 147 | 105 | 42 | 15 |
| 20 | Billy Cowan | of | 31 | 25 | - | MLB | 139 | 520 | 390 | 52 | 3.6 | .287 | -.187 | .163 | 0.14 | 3.7 | 81 | 39 | 32.5 | 3.5 | 24.6 | 1.12 | 0.3 | 147 | 105 | 42 | 36 |
| 18 | Andre Rodgers | ss | 62 | 29 | - | MLB | 129 | 508 | 358 | 55 | 4.2 | .271 | -.112 | .132 | 0.60 | 2.4 | 75 | 32 | 29.9 | 10.4 | 17.3 | 0.80 | 0.3 | 145 | 102 | 43 | 13 |
| 19 | Jimmy Stewart | of-2b | 41 | 25 | - | MLB | 132 | 481 | 338 | 48 | 3.8 | .286 | -.130 | .063 | 0.80 | 0.6 | 85 | 20 | 19.0 | 10.2 | 12.7 | 1.01 | 0.2 | 83 | 49 | 34 | 10 |
| 6 | Dick Bertell | c | 74 | 28 | - | MLB | 112 | 395 | 288 | 33 | 3.0 | .282 | -.142 | .082 | 0.49 | 1.0 | 66 | 18 | 21.4 | 8.4 | 17.0 | 0.97 | 0.4 | 151 | 99 | 52 | 15 |
| 17 | Joey Amalfitano | 2b-3b | 66 | 30 | - | MLB | 100 | 372 | 266 | 43 | 4.4 | .266 | -.133 | .132 | 0.95 | 1.1 | 49 | 29 | 37.2 | 10.8 | 11.3 | 1.14 | 0.3 | 114 | 74 | 40 | 8 |
| 12 | Len Gabrielson | of | 68 | 24 | - | MLB | 89 | 293 | 211 | 32 | 4.1 | .270 | -.158 | .111 | 0.51 | 1.7 | 49 | 18 | 26.9 | 6.5 | 12.6 | 1.18 | 0.4 | 110 | 75 | 35 | 9 |
| 24 | Lou Brock | of | 7 | 25 | UDFA: 1961 | MLB | 52 | 231 | 168 | 23 | 3.6 | .301 | -.158 | .089 | 0.33 | 0.9 | 41 | 13 | 24.1 | 5.6 | 17.3 | 1.53 | 0.3 | 69 | 43 | 26 | 3 |
| 27 | Doug Clemens | of | - | 25 | - | MLB | 54 | 160 | 104 | 24 | 6.3 | .316 | -.150 | .142 | 0.82 | 1.3 | 25 | 14 | 35.9 | 11.3 | 13.8 | 1.26 | 0.0 | 7 | 4 | 3 | 0 |
| 5 | Jimmie Schaffer | c | - | 28 | - | MLB | 54 | 140 | 107 | 11 | 2.7 | .223 | -.082 | .115 | 1.00 | 1.4 | 16 | 9 | 36.0 | 12.1 | 12.1 | 0.87 | 0.1 | 13 | 6 | 7 | 1 |
| 46 | Larry Jackson | p | - | 33 | - | MLB | 40 | 120 | 101 | 0 | -0.0 | .227 | -.175 | .027 | 0.04 | 0.0 | 17 | 3 | 15.0 | 0.8 | 21.7 | 1.44 | 0.2 | 19 | 16 | 3 | 4 |
| 21 | Ellis Burton | of | - | 27 | - | MLB | 42 | 125 | 91 | 11 | 3.2 | .222 | .010 | .124 | 0.77 | 1.6 | 13 | 7 | 35.0 | 13.6 | 17.6 | 1.61 | 0.0 | 6 | 4 | 2 | 2 |
| 15 | Leo Burke | of-2b | - | 30 | - | MLB | 59 | 111 | 78 | 9 | 3.3 | .366 | -.194 | .078 | 0.23 | 0.9 | 22 | 5 | 18.5 | 6.3 | 27.9 | 1.58 | 0.2 | 20 | 12 | 8 | 8 |
| 7 | Ron Campbell | 2b-ss | - | 24 | - | MLB | 26 | 95 | 70 | 10 | 3.9 | .338 | -.272 | .119 | 0.05 | 1.1 | 17 | 8 | 32.0 | 1.1 | 22.1 | 1.00 | 0.0 | 0 | 0 | 0 | 0 |
| 37 | Dick Ellsworth | p | - | 24 | - | MLB | 37 | 98 | 90 | -9 | -2.8 | .089 | .000 | .000 | 0.09 | 0.0 | 4 | 0 | 0.0 | 4.1 | 43.9 | 1.94 | 0.4 | 44 | 28 | 16 | 4 |
| 8 | Vic Roznovsky | c | - | 25 | - | MLB | 35 | 84 | 65 | 2 | 0.9 | .254 | -.145 | .014 | 0.28 | 0.0 | 14 | 1 | 6.7 | 6.0 | 21.4 | 0.86 | 0.0 | 0 | 0 | 0 | 0 |
| 31 | Bob Buhl | p | - | 35 | - | MLB | 36 | 85 | 73 | -4 | -1.6 | .163 | -.014 | .000 | 0.19 | 0.0 | 7 | 0 | 0.0 | 7.1 | 36.5 | 1.39 | 0.4 | 36 | 25 | 11 | 6 |
| 33 | Lew Burdette | p | - | 37 | - | MLB | 28 | 50 | 34 | 7 | 5.5 | .345 | -.209 | .186 | 0.25 | 4.0 | 9 | 3 | 25.0 | 6.0 | 24.0 | 1.42 | 0.2 | 9 | 8 | 1 | 2 |
| 20,28 | Billy Ott | of | - | 23 | - | MLB | 20 | 43 | 34 | 2 | 1.3 | .241 | -.128 | .077 | 0.30 | 0.0 | 4 | 3 | 42.9 | 7.0 | 23.3 | 1.18 | 0.1 | 4 | 3 | 1 | 1 |
| 32 | Ernie Broglio | p | - | 28 | - | MLB | 18 | 38 | 27 | 3 | 3.3 | .357 | -.257 | .028 | 0.14 | 0.0 | 9 | 1 | 10.0 | 2.6 | 18.4 | 1.33 | 0.4 | 14 | 9 | 5 | 1 |
| 7 | Merritt Ranew | c | - | 26 | - | MLB | 16 | 36 | 31 | -1 | -1.2 | .111 | -.030 | .000 | 0.33 | 0.0 | 3 | 0 | 0.0 | 5.6 | 16.7 | 2.57 | 0.4 | 13 | 11 | 2 | 1 |
| 22 | John Boccabella | c-1b | - | 23 | UDFA: 1963 | MLB | 9 | 23 | 15 | 5 | 9.1 | .450 | -.391 | .174 | 0.00 | 0.0 | 6 | 3 | 33.3 | 0.0 | 13.0 | 1.60 | 0.0 | 0 | 0 | 0 | 0 |
| 43 | Lindy McDaniel | p | - | 28 | UDFA: 1958 | MLB | 63 | 17 | 15 | -1 | -2.3 | .286 | -.125 | .000 | 0.00 | 0.0 | 2 | 0 | 0.0 | 0.0 | 52.9 | 5.00 | 0.0 | 0 | 0 | 0 | 0 |
| 28 | Lee Gregory | p | - | 26 | - | MLB | 19 | 16 | 13 | -1 | -1.5 | .143 | .077 | .000 | 0.50 | 0.0 | 1 | 0 | 0.0 | 18.8 | 37.5 | 2.00 | 0.3 | 4 | 3 | 1 | 3 |
| 11 | Don Kessinger | ss | - | 21 | UDFA: 1964 | MLB | 4 | 12 | 10 | 0 | -0.0 | .182 | -.167 | .000 | 0.00 | 0.0 | 2 | 0 | 0.0 | 0.0 | 8.3 | 1.50 | 0.0 | 0 | 0 | 0 | 0 |
| 41 | Sterling Slaughter | p | - | 22 | - | MLB | 20 | 13 | 11 | -1 | -2.8 | .250 | .000 | .000 | 0.13 | 0.0 | 1 | 0 | 0.0 | 7.7 | 61.5 | 2.00 | 0.0 | 0 | 0 | 0 | 0 |
| 27 | Don Landrum | of | - | 28 | - | MLB | 11 | 12 | 12 | - | - | .000 | .091 | .000 | 0.50 | 0.0 | 0 | 0 | 0.0 | 8.3 | 16.7 | 1.25 | 1.5 | 18 | 11 | 7 | 0 |
| 45 | Fred Norman | p | - | 21 | UDFA: 1961 | MLB | 8 | 11 | 10 | -1 | -2.7 | .167 | -.091 | .000 | 0.00 | 0.0 | 1 | 0 | 0.0 | 0.0 | 45.5 | 1.50 | 0.0 | 0 | 0 | 0 | 0 |
| 34 | Cal Koonce | p | - | 23 | - | MLB | 6 | 10 | 10 | - | - | .000 | .000 | .000 | 0.00 | 0.0 | 0 | 0 | 0.0 | 0.0 | 40.0 | 0.50 | 0.0 | 0 | 0 | 0 | 0 |
| 36 | Don Elston | p | - | 35 | - | MLB | 48 | 6 | 5 | 0 | -0.3 | .200 | -.167 | .000 | 0.00 | 0.0 | 1 | 0 | 0.0 | 0.0 | 16.7 | -- | 0.2 | 1 | 1 | 0 | 0 |
| 30 | Wayne Schurr | p | - | 26 | - | MLB | 26 | 6 | 5 | -1 | -4.1 | .000 | .200 | .000 | 0.20 | 0.0 | 0 | 0 | 0.0 | 16.7 | 83.3 | -- | 0.0 | 0 | 0 | 0 | 0 |
| 40 | Glen Hobbie | p | - | 28 | - | MLB | 8 | 7 | 5 | 0 | -0.5 | .000 | .400 | .000 | 1.00 | 0.0 | 0 | 0 | 0.0 | 28.6 | 28.6 | 0.50 | 0.0 | 0 | 0 | 0 | 0 |
| 39 | Paul Toth | p | - | 29 | - | MLB | 4 | 3 | 2 | 0 | 1.8 | 1.000 | -.333 | .000 | 0.00 | 0.0 | 1 | 0 | 0.0 | 0.0 | 66.7 | -- | 0.0 | 0 | 0 | 0 | 0 |
| 11 | Paul Popovich | 2b-ss | - | 23 | UDFA: 1960 | MLB | 1 | 1 | 0 | 1 | -- | 1.000 | -1.000 | .000 | -- | 0.0 | 1 | 0 | 0.0 | 0.0 | 0.0 | -- | 0.0 | 0 | 0 | 0 | 0 |
| 39 | Jake Jaeckel | p | - | 22 | - | MLB | 4 | 1 | 1 | - | - | .000 | .000 | .000 | -- | 0.0 | 0 | 0 | 0.0 | 0.0 | 0.0 | -- | 0.0 | 0 | 0 | 0 | 0 |
| 38 | John Flavin | p | - | 22 | - | MLB | 5 | 1 | 1 | - | - | .000 | .000 | .000 | -- | 0.0 | 0 | 0 | 0.0 | 0.0 | 0.0 | -- | 0.0 | 0 | 0 | 0 | 0 |
| 42 | Freddie Burdette | p | - | 27 | - | MLB | 18 | 1 | 0 | 1 | -- | 1.000 | -1.000 | .000 | -- | 0.0 | 1 | 0 | 0.0 | 0.0 | 0.0 | -- | 0.0 | 0 | 0 | 0 | 0 |