| 1964-04-14 | @ LAN | 1 | L 0-4 | 0-1 | 6 | 50,451 | Ernie Broglio | Sandy Koufax | Sandy Koufax | Ernie Broglio | | 0 | 4 | -4 |
| 1964-04-15 | @ LAN | 2 | W 6-2 | 1-1 | 5 | 28,025 | Bob Gibson | Don Drysdale | Bob Gibson | Don Drysdale | | 6 | 6 | 0 |
| 1964-04-16 | @ SFN | 3 | W 2-0 | 2-1 | 2 | 9,875 | Curt Simmons | Bob Hendley | Curt Simmons | Bob Hendley | | 8 | 6 | 2 |
| 1964-04-17 | @ SFN | 4 | L 4-5 | 2-2 | 5 | 19,524 | Roger Craig | Billy O'Dell | Bob Shaw | Bobby Shantz | | 12 | 11 | 1 |
| 1964-04-18 | @ SFN | 5 | W 3-2 | 3-2 | 4 | 23,483 | Ernie Broglio | Bobby Bolin | Ernie Broglio | Bobby Bolin | | 15 | 13 | 2 |
| 1964-04-19 | @ HOU | 6 | W 6-1 | 4-2 | 2 | 12,913 | Bob Gibson | Don Nottebart | Bob Gibson | Don Nottebart | | 21 | 14 | 7 |
| 1964-04-20 | @ HOU | 7 | L 1-7 | 4-3 | 4 | 7,441 | Ray Sadecki | Turk Farrell | Turk Farrell | Ray Sadecki | | 22 | 21 | 1 |
| 1964-04-22 | vs LAN | 8 | W 7-6 | 5-3 | 4 | 31,410 | Curt Simmons | Sandy Koufax | Curt Simmons | Sandy Koufax | Roger Craig | 29 | 27 | 2 |
| 1964-04-23 | vs LAN | 9 | L 5-7 | 5-4 | 5 | 10,276 | Ernie Broglio | Don Drysdale | Ron Perranoski | Ron Taylor | | 34 | 34 | 0 |
| 1964-04-24 | vs HOU | 10 | W 3-2 | 6-4 | 4 | 6,789 | Bob Gibson | Don Nottebart | Lew Burdette | Hal Woodeshick | | 37 | 36 | 1 |
| 1964-04-25 | vs HOU | 11 | L 2-4 | 6-5 | 6 | 11,796 | Roger Craig | Turk Farrell | Turk Farrell | Bobby Shantz | Hal Woodeshick | 39 | 40 | -1 |
| 1964-04-26 | vs HOU | 12 | L 4-6 | 6-6 | 6 | 9,700 | Curt Simmons | Jim Owens | Jim Owens | Curt Simmons | Hal Woodeshick | 43 | 46 | -3 |
| 1964-04-28 | vs NYN | 13 | W 8-0 | 7-6 | 5 | 3,471 | Ernie Broglio | Al Jackson | Ernie Broglio | Al Jackson | | 51 | 46 | 5 |
| 1964-04-29 | vs NYN | 14 | W 4-3 | 8-6 | 4 | 3,844 | Bob Gibson | Jack Fisher | Bobby Shantz | Larry Bearnarth | | 55 | 49 | 6 |
| 1964-05-01 | vs PIT | 15 | W 6-2 | 9-6 | 3 | 14,701 | Roger Craig | Vern Law | Roger Craig | Vern Law | | 61 | 51 | 10 |
| 1964-05-02 | vs PIT | 16 | L 4-5 | 9-7 | 4 | 12,534 | Curt Simmons | Bob Friend | Tommie Sisk | Curt Simmons | Frank Bork | 65 | 56 | 9 |
| 1964-05-03 | vs PIT | 17 | L 8-12 | 9-8 | 6 | 11,051 | Ernie Broglio | Bob Veale | Don Schwall | Ray Sadecki | Roy Face | 73 | 68 | 5 |
| 1964-05-04 | vs PHI | 18 | W 9-2 | 10-8 | 5 | 7,437 | Bob Gibson | Dennis Bennett | Roger Craig | Dennis Bennett | | 82 | 70 | 12 |
| 1964-05-05 | vs PHI | 19 | W 2-1 | 11-8 | 5 | 10,443 | Ray Washburn | Jim Bunning | Ray Washburn | Jim Bunning | Ron Taylor | 84 | 71 | 13 |
| 1964-05-06 | @ PIT | 20 | L 0-1 | 11-9 | 6 | 8,659 | Ray Sadecki | Bob Friend | Bob Friend | Ray Sadecki | | 84 | 72 | 12 |
| 1964-05-07 | @ PIT | 21 | W 4-2 | 12-9 | 4 | 7,219 | Curt Simmons | Bob Veale | Curt Simmons | Bob Veale | Roger Craig | 88 | 74 | 14 |
| 1964-05-08 | @ NYN | 22 | L 4-5 | 12-10 | 5 | 32,386 | Ernie Broglio | Jack Fisher | Larry Bearnarth | Bobby Shantz | | 92 | 79 | 13 |
| 1964-05-09 | @ NYN | 23 | W 5-1 | 13-10 | 4 | 16,757 | Bob Gibson | Galen Cisco | Bob Gibson | Galen Cisco | | 97 | 80 | 17 |
| 1964-05-10 | @ NYN | 24 | L 1-4 | 14-11 | 4 | 0 | Roger Craig | Tracy Stallard | Tracy Stallard | Roger Craig | | 98 | 84 | 14 |
| 1964-05-10 | @ NYN | 25 | W 10-1 | 14-11 | 4 | 30,776 | Ray Washburn | Jerry Hinsley | Ray Washburn | Jerry Hinsley | Ron Taylor | 108 | 85 | 23 |
| 1964-05-11 | @ PHI | 26 | W 3-2 | 15-11 | 4 | 11,200 | Ray Sadecki | Ray Culp | Ray Sadecki | Ray Culp | | 111 | 87 | 24 |
| 1964-05-12 | @ PHI | 27 | W 4-2 | 16-11 | 4 | 14,412 | Curt Simmons | Art Mahaffey | Curt Simmons | Art Mahaffey | Roger Craig | 115 | 89 | 26 |
| 1964-05-14 | @ PHI | 28 | L 2-3 | 16-12 | 4 | 16,626 | Ernie Broglio | Jim Bunning | Jim Bunning | Ernie Broglio | Ed Roebuck | 117 | 92 | 25 |
| 1964-05-15 | vs MLN | 29 | W 10-6 | 17-12 | 4 | 22,400 | Bob Gibson | Denny Lemaster | Roger Craig | Bobby Tiefenauer | | 127 | 98 | 29 |
| 1964-05-16 | vs MLN | 30 | W 6-5 | 18-12 | 4 | 13,564 | Ray Sadecki | Bob Sadowski | Ray Sadecki | Bob Sadowski | Ron Taylor | 133 | 103 | 30 |
| 1964-05-17 | vs MLN | 31 | W 7-3 | 19-13 | 4 | 0 | Curt Simmons | Hank Fischer | Curt Simmons | Hank Fischer | | 140 | 106 | 34 |
| 1964-05-17 | vs MLN | 32 | L 2-4 | 19-13 | 4 | 28,594 | Ray Washburn | Tony Cloninger | Tony Cloninger | Ray Washburn | | 142 | 110 | 32 |
| 1964-05-19 | vs CHN | 33 | L 4-7 | 19-14 | 4 | 8,541 | Ernie Broglio | Dick Ellsworth | Dick Ellsworth | Ernie Broglio | | 146 | 117 | 29 |
| 1964-05-20 | vs CHN | 34 | W 1-0 | 20-14 | 4 | 8,612 | Bob Gibson | Larry Jackson | Bob Gibson | Larry Jackson | | 147 | 117 | 30 |
| 1964-05-21 | vs CHN | 35 | W 10-3 | 21-14 | 4 | 7,877 | Ray Sadecki | Glen Hobbie | Ray Sadecki | Glen Hobbie | | 157 | 120 | 37 |
| 1964-05-22 | @ MLN | 36 | W 6-1 | 22-14 | 3 | 20,489 | Curt Simmons | Tony Cloninger | Curt Simmons | Tony Cloninger | | 163 | 121 | 42 |
| 1964-05-23 | @ MLN | 37 | L 4-8 | 22-15 | 3 | 10,567 | Roger Craig | Hank Fischer | Billy Hoeft | Roger Craig | | 167 | 129 | 38 |
| 1964-05-24 | @ MLN | 38 | L 4-7 | 22-17 | 4 | 0 | Ray Washburn | Warren Spahn | Warren Spahn | Ray Sadecki | Bob Sadowski | 171 | 136 | 35 |
| 1964-05-24 | @ MLN | 39 | L 0-10 | 22-17 | 4 | 26,084 | Ernie Broglio | Denny Lemaster | Denny Lemaster | Ernie Broglio | | 171 | 146 | 25 |
| 1964-05-27 | vs SFN | 40 | L 1-2 | 22-18 | 4 | 14,786 | Bob Gibson | Juan Marichal | Juan Marichal | Bob Gibson | | 172 | 148 | 24 |
| 1964-05-28 | vs SFN | 41 | L 1-2 | 22-19 | 5 | 14,092 | Curt Simmons | Bob Hendley | Bob Hendley | Curt Simmons | Bobby Bolin | 173 | 150 | 23 |
| 1964-05-29 | vs CIN | 42 | W 4-3 | 23-19 | 4 | 10,219 | Ray Sadecki | Jim O'Toole | Ray Sadecki | Jim O'Toole | | 177 | 153 | 24 |
| 1964-05-30 | vs CIN | 43 | W 7-1 | 24-19 | 4 | 11,051 | Ernie Broglio | Sammy Ellis | Ernie Broglio | Sammy Ellis | | 184 | 154 | 30 |
| 1964-05-31 | vs CIN | 44 | L 0-6 | 25-20 | 4 | 0 | Ray Washburn | Bob Purkey | Bob Purkey | Ray Washburn | | 184 | 160 | 24 |
| 1964-05-31 | vs CIN | 45 | W 2-1 | 25-20 | 4 | 20,240 | Bob Gibson | John Tsitouris | Bob Gibson | John Tsitouris | | 186 | 161 | 25 |
| 1964-06-02 | @ CHN | 46 | L 2-5 | 25-21 | 4 | 5,129 | Curt Simmons | Larry Jackson | Larry Jackson | Curt Simmons | | 188 | 166 | 22 |
| 1964-06-03 | @ CHN | 47 | W 7-5 | 26-21 | 4 | 6,718 | Ray Sadecki | Bob Buhl | Ray Sadecki | Bob Buhl | Roger Craig | 195 | 171 | 24 |
| 1964-06-04 | @ CHN | 48 | L 1-2 | 26-22 | 4 | 8,019 | Bob Gibson | Dick Ellsworth | Dick Ellsworth | Bob Gibson | | 196 | 173 | 23 |
| 1964-06-05 | @ CIN | 49 | L 4-5 | 26-23 | 5 | 10,692 | Glen Hobbie | Bob Purkey | Joey Jay | Roger Craig | | 200 | 178 | 22 |
| 1964-06-06 | @ CIN | 50 | L 0-3 | 26-24 | 5 | 17,386 | Ray Washburn | John Tsitouris | John Tsitouris | Ray Washburn | Sammy Ellis | 200 | 181 | 19 |
| 1964-06-07 | @ CIN | 51 | L 6-11 | 26-25 | 5 | 12,925 | Curt Simmons | Joe Nuxhall | Joe Nuxhall | Curt Simmons | Joey Jay | 206 | 192 | 14 |
| 1964-06-09 | @ SFN | 52 | W 1-0 | 27-25 | 5 | 14,348 | Ray Sadecki | Juan Marichal | Ray Sadecki | Juan Marichal | | 207 | 192 | 15 |
| 1964-06-10 | @ SFN | 53 | L 0-3 | 28-26 | 5 | 0 | Bob Gibson | Bob Hendley | Bob Hendley | Bob Gibson | Gaylord Perry | 207 | 195 | 12 |
| 1964-06-10 | @ SFN | 54 | W 2-1 | 28-26 | 5 | 16,684 | Glen Hobbie | Ron Herbel | Glen Hobbie | Ron Herbel | | 209 | 196 | 13 |
| 1964-06-11 | @ LAN | 55 | L 0-5 | 28-27 | 5 | 29,272 | Ray Washburn | Don Drysdale | Don Drysdale | Ray Washburn | | 209 | 201 | 8 |
| 1964-06-12 | @ LAN | 56 | L 0-3 | 28-28 | 5 | 44,476 | Ernie Broglio | Sandy Koufax | Sandy Koufax | Ernie Broglio | | 209 | 204 | 5 |
| 1964-06-13 | @ LAN | 57 | L 2-3 | 28-29 | 5 | 29,199 | Ray Sadecki | Joe Moeller | Joe Moeller | Ray Sadecki | Ron Perranoski | 211 | 207 | 4 |
| 1964-06-14 | @ HOU | 58 | L 1-4 | 28-30 | 7 | 15,341 | Bob Gibson | Turk Farrell | Turk Farrell | Bob Gibson | | 212 | 211 | 1 |
| 1964-06-15 | @ HOU | 59 | L 3-9 | 28-31 | 7 | 8,584 | Glen Hobbie | Don Nottebart | Jim Owens | Glen Hobbie | | 215 | 220 | -5 |
| 1964-06-16 | @ HOU | 60 | W 7-1 | 29-31 | 5 | 12,383 | Curt Simmons | Bob Bruce | Curt Simmons | Bob Bruce | | 222 | 221 | 1 |
| 1964-06-17 | @ HOU | 61 | W 2-1 | 30-31 | 5 | 10,777 | Ray Washburn | Ken Johnson | Ray Washburn | Ken Johnson | Ron Taylor | 224 | 222 | 2 |
| 1964-06-18 | vs SFN | 62 | W 7-6 | 31-31 | 5 | 14,876 | Ray Sadecki | Juan Marichal | Ray Sadecki | Juan Marichal | Ron Taylor | 231 | 228 | 3 |
| 1964-06-19 | vs SFN | 63 | W 3-1 | 32-31 | 5 | 24,533 | Bob Gibson | Ron Herbel | Bob Gibson | Ron Herbel | Ron Taylor | 234 | 229 | 5 |
| 1964-06-20 | vs SFN | 64 | L 3-14 | 32-32 | 5 | 20,646 | Glen Hobbie | Bob Hendley | Bob Hendley | Glen Hobbie | Jim Duffalo | 237 | 243 | -6 |
| 1964-06-21 | vs SFN | 65 | L 3-7 | 32-33 | 5 | 25,848 | Curt Simmons | Jack Sanford | Jack Sanford | Curt Simmons | Gaylord Perry | 240 | 250 | -10 |
| 1964-06-23 | vs HOU | 66 | W 5-4 | 33-33 | 5 | 9,679 | Ray Washburn | Turk Farrell | Ron Taylor | Don Larsen | Mike Cuellar | 245 | 254 | -9 |
| 1964-06-24 | vs HOU | 67 | L 5-7 | 33-34 | 5 | 8,621 | Ray Sadecki | Don Nottebart | Jim Owens | Ray Sadecki | Hal Woodeshick | 250 | 261 | -11 |
| 1964-06-25 | vs HOU | 68 | W 4-2 | 34-34 | 5 | 6,842 | Roger Craig | Bob Bruce | Roger Craig | Bob Bruce | Glen Hobbie | 254 | 263 | -9 |
| 1964-06-26 | vs PHI | 69 | L 5-6 | 34-35 | 5 | 18,484 | Bob Gibson | Jim Bunning | Ed Roebuck | Ron Taylor | | 259 | 269 | -10 |
| 1964-06-27 | vs PHI | 70 | W 9-4 | 35-35 | 5 | 12,388 | Curt Simmons | Dennis Bennett | Curt Simmons | Rick Wise | | 268 | 273 | -5 |
| 1964-06-28 | vs PHI | 71 | L 0-5 | 36-36 | 5 | 0 | Mike Cuellar | Chris Short | Chris Short | Mike Cuellar | | 268 | 278 | -10 |
| 1964-06-28 | vs PHI | 72 | W 8-2 | 36-36 | 5 | 27,805 | Ray Sadecki | Ray Culp | Ray Sadecki | Ray Culp | | 276 | 280 | -4 |
| 1964-06-29 | vs MLN | 73 | L 4-7 | 36-37 | 5 | 11,336 | Ray Washburn | Dan Schneider | Bobby Tiefenauer | Bob Gibson | | 280 | 287 | -7 |
| 1964-06-30 | vs MLN | 74 | L 4-5 | 36-38 | 6 | 7,484 | Roger Craig | Wade Blasingame | Bob Sadowski | Roger Craig | Bobby Tiefenauer | 284 | 292 | -8 |
| 1964-07-01 | @ MLN | 75 | W 6-1 | 37-38 | 5 | 13,608 | Curt Simmons | Hank Fischer | Curt Simmons | Hank Fischer | | 290 | 293 | -3 |
| 1964-07-02 | @ MLN | 76 | W 4-3 | 38-38 | 5 | 6,863 | Ray Sadecki | Warren Spahn | Ray Sadecki | Warren Spahn | Bob Humphreys | 294 | 296 | -2 |
| 1964-07-03 | @ CIN | 77 | L 1-4 | 38-39 | 5 | 11,975 | Bob Gibson | John Tsitouris | John Tsitouris | Bob Gibson | | 295 | 300 | -5 |
| 1964-07-04 | @ CIN | 78 | L 2-3 | 38-40 | 5 | 21,320 | Mike Cuellar | Jim O'Toole | Jim O'Toole | Mike Cuellar | Billy McCool | 297 | 303 | -6 |
| 1964-07-05 | @ CIN | 79 | W 3-1 | 39-40 | 5 | 11,854 | Roger Craig | Joey Jay | Roger Craig | Joey Jay | | 300 | 304 | -4 |
| 1964-07-09 | @ NYN | 80 | L 3-4 | 39-41 | 5 | 13,804 | Curt Simmons | Al Jackson | Al Jackson | Curt Simmons | | 303 | 308 | -5 |
| 1964-07-10 | @ NYN | 81 | W 3-1 | 40-41 | 5 | 33,634 | Bob Gibson | Jack Fisher | Bob Gibson | Jack Fisher | | 306 | 309 | -3 |
| 1964-07-11 | @ NYN | 82 | W 11-4 | 41-41 | 5 | 19,475 | Ray Sadecki | Tracy Stallard | Ray Sadecki | Tracy Stallard | Ron Taylor | 317 | 313 | 4 |
| 1964-07-13 | @ PIT | 83 | W 5-4 | 43-41 | 5 | 0 | Roger Craig | Steve Blass | Ron Taylor | Tommie Sisk | | 322 | 317 | 5 |
| 1964-07-13 | @ PIT | 84 | W 12-5 | 43-41 | 5 | 14,773 | Mike Cuellar | Vern Law | Mike Cuellar | Vern Law | Ray Washburn | 334 | 322 | 12 |
| 1964-07-14 | vs LAN | 85 | W 8-7 | 44-41 | 5 | 24,817 | Curt Simmons | Sandy Koufax | Ron Taylor | Ron Perranoski | | 342 | 329 | 13 |
| 1964-07-15 | vs LAN | 86 | L 3-13 | 44-42 | 5 | 17,304 | Bob Gibson | Larry Miller | Larry Miller | Bob Gibson | Ron Perranoski | 345 | 342 | 3 |
| 1964-07-16 | vs LAN | 87 | L 2-10 | 44-43 | 5 | 15,780 | Ray Sadecki | Joe Moeller | Joe Moeller | Ray Sadecki | Bob Miller | 347 | 352 | -5 |
| 1964-07-17 | vs NYN | 88 | W 9-8 | 45-43 | 5 | 10,759 | Roger Craig | Galen Cisco | Mike Cuellar | Tracy Stallard | Bob Gibson | 356 | 360 | -4 |
| 1964-07-18 | vs NYN | 89 | W 15-7 | 46-43 | 5 | 9,424 | Glen Hobbie | Al Jackson | Ron Taylor | Bill Wakefield | Ray Sadecki | 371 | 367 | 4 |
| 1964-07-19 | vs NYN | 90 | L 2-3 | 47-44 | 5 | 0 | Curt Simmons | Jack Fisher | Jack Fisher | Curt Simmons | | 373 | 370 | 3 |
| 1964-07-19 | vs NYN | 91 | W 7-6 | 47-44 | 5 | 18,377 | Bob Gibson | Frank Lary | Bob Gibson | Willard Hunter | | 380 | 376 | 4 |
| 1964-07-21 | vs PIT | 92 | L 4-8 | 47-45 | 5 | 11,805 | Ray Sadecki | Joe Gibbon | Joe Gibbon | Ray Sadecki | Frank Bork | 384 | 384 | 0 |
| 1964-07-22 | vs PIT | 93 | L 2-13 | 47-46 | 5 | 11,089 | Roger Craig | Bob Veale | Bob Veale | Roger Craig | | 386 | 397 | -11 |
| 1964-07-23 | vs PIT | 94 | L 5-8 | 47-47 | 5 | 7,893 | Mike Cuellar | Don Schwall | Steve Blass | Mike Cuellar | Roy Face | 391 | 405 | -14 |
| 1964-07-24 | @ PHI | 95 | L 1-9 | 47-48 | 5 | 22,628 | Bob Gibson | Chris Short | Chris Short | Bob Gibson | | 392 | 414 | -22 |
| 1964-07-25 | @ PHI | 96 | W 10-9 | 48-48 | 5 | 10,948 | Curt Simmons | Dennis Bennett | Curt Simmons | Dennis Bennett | Mike Cuellar | 402 | 423 | -21 |
| 1964-07-26 | @ PHI | 97 | W 6-1 | 50-48 | 5 | 0 | Gordie Richardson | John Boozer | Gordie Richardson | John Boozer | | 408 | 424 | -16 |
| 1964-07-26 | @ PHI | 98 | W 4-1 | 50-48 | 5 | 28,118 | Ray Sadecki | Art Mahaffey | Ray Sadecki | Art Mahaffey | | 412 | 425 | -13 |
| 1964-07-28 | @ CHN | 99 | W 12-7 | 51-48 | 5 | 16,052 | Bob Gibson | Ernie Broglio | Ron Taylor | Larry Jackson | Mike Cuellar | 424 | 432 | -8 |
| 1964-07-29 | @ CHN | 100 | W 9-1 | 52-48 | 5 | 16,781 | Curt Simmons | Lew Burdette | Curt Simmons | Lew Burdette | | 433 | 433 | 0 |
| 1964-07-30 | @ CHN | 101 | W 5-2 | 53-48 | 5 | 11,173 | Ray Sadecki | Dick Ellsworth | Ray Sadecki | Dick Ellsworth | Roger Craig | 438 | 435 | 3 |
| 1964-07-31 | vs CIN | 102 | L 6-7 | 53-49 | 5 | 22,136 | Gordie Richardson | John Tsitouris | John Tsitouris | Gordie Richardson | Bob Purkey | 444 | 442 | 2 |
| 1964-08-01 | vs CIN | 103 | L 5-6 | 53-50 | 5 | 13,057 | Bob Gibson | Joey Jay | Joey Jay | Bob Gibson | Sammy Ellis | 449 | 448 | 1 |
| 1964-08-02 | vs CIN | 104 | W 5-4 | 54-50 | 5 | 14,010 | Curt Simmons | Jim Maloney | Mike Cuellar | Billy McCool | Ron Taylor | 454 | 452 | 2 |
| 1964-08-04 | vs CHN | 105 | L 0-4 | 54-51 | 5 | 12,723 | Ray Sadecki | Lew Burdette | Lew Burdette | Ray Sadecki | | 454 | 456 | -2 |
| 1964-08-05 | vs CHN | 106 | W 4-2 | 55-51 | 5 | 11,614 | Gordie Richardson | Bob Buhl | Gordie Richardson | Bob Buhl | Bob Humphreys | 458 | 458 | 0 |
| 1964-08-06 | vs CHN | 107 | W 5-3 | 56-51 | 5 | 8,258 | Bob Gibson | Dick Ellsworth | Bob Gibson | Dick Ellsworth | Barney Schultz | 463 | 461 | 2 |
| 1964-08-07 | vs HOU | 108 | W 4-0 | 57-51 | 5 | 14,344 | Curt Simmons | Hal Brown | Curt Simmons | Hal Brown | | 467 | 461 | 6 |
| 1964-08-08 | vs HOU | 109 | L 3-4 | 57-52 | 5 | 14,842 | Ron Taylor | Don Nottebart | Don Nottebart | Ron Taylor | Jim Owens | 470 | 465 | 5 |
| 1964-08-09 | vs HOU | 110 | W 8-2 | 58-52 | 5 | 19,658 | Ray Sadecki | Bob Bruce | Ray Sadecki | Bob Bruce | | 478 | 467 | 11 |
| 1964-08-10 | vs SFN | 111 | W 2-1 | 59-52 | 5 | 18,779 | Bob Gibson | Ron Herbel | Bob Gibson | Ron Herbel | Barney Schultz | 480 | 468 | 12 |
| 1964-08-11 | vs SFN | 112 | L 3-6 | 59-53 | 5 | 21,075 | Curt Simmons | Bob Hendley | Bob Hendley | Curt Simmons | Billy Pierce | 483 | 474 | 9 |
| 1964-08-12 | vs SFN | 113 | W 6-4 | 60-53 | 5 | 17,676 | Roger Craig | Gaylord Perry | Roger Craig | Bob Shaw | Barney Schultz | 489 | 478 | 11 |
| 1964-08-14 | @ LAN | 114 | W 4-3 | 61-53 | 5 | 33,835 | Ray Sadecki | Don Drysdale | Ray Sadecki | Don Drysdale | Mike Cuellar | 493 | 481 | 12 |
| 1964-08-15 | @ LAN | 115 | L 3-4 | 61-54 | 5 | 22,218 | Bob Gibson | Joe Moeller | Joe Moeller | Bob Gibson | Ron Perranoski | 496 | 485 | 11 |
| 1964-08-16 | @ LAN | 116 | L 0-3 | 62-55 | 5 | 0 | Gordie Richardson | Sandy Koufax | Sandy Koufax | Gordie Richardson | | 496 | 488 | 8 |
| 1964-08-16 | @ LAN | 117 | W 4-0 | 62-55 | 5 | 38,072 | Curt Simmons | Larry Miller | Curt Simmons | Larry Miller | | 500 | 488 | 12 |
| 1964-08-17 | @ HOU | 118 | W 3-1 | 63-55 | 5 | 8,053 | Roger Craig | Hal Brown | Mike Cuellar | Hal Brown | Barney Schultz | 503 | 489 | 14 |
| 1964-08-18 | @ HOU | 119 | W 5-2 | 64-55 | 5 | 8,617 | Ray Sadecki | Don Larsen | Ray Sadecki | Don Larsen | Barney Schultz | 508 | 491 | 17 |
| 1964-08-19 | @ HOU | 120 | L 7-8 | 64-56 | 5 | 8,149 | Bob Gibson | Don Nottebart | Jim Owens | Barney Schultz | | 515 | 499 | 16 |
| 1964-08-21 | @ SFN | 121 | W 6-5 | 65-56 | 5 | 19,644 | Curt Simmons | Bob Hendley | Ron Taylor | Jim Duffalo | Barney Schultz | 521 | 504 | 17 |
| 1964-08-22 | @ SFN | 122 | L 2-4 | 65-57 | 5 | 22,910 | Roger Craig | Bobby Bolin | Bobby Bolin | Roger Craig | | 523 | 508 | 15 |
| 1964-08-23 | @ SFN | 123 | L 2-3 | 65-58 | 5 | 28,712 | Ray Sadecki | Gaylord Perry | Billy O'Dell | Barney Schultz | | 525 | 511 | 14 |
| 1964-08-24 | vs PIT | 124 | W 5-1 | 66-58 | 5 | 10,881 | Bob Gibson | Bob Friend | Bob Gibson | Bob Friend | | 530 | 512 | 18 |
| 1964-08-25 | vs PIT | 125 | W 7-6 | 67-58 | 4 | 8,664 | Curt Simmons | Bob Veale | Ron Taylor | Al McBean | | 537 | 518 | 19 |
| 1964-08-26 | vs PIT | 126 | W 4-2 | 68-58 | 4 | 9,662 | Mike Cuellar | Frank Bork | Mike Cuellar | Frank Bork | | 541 | 520 | 21 |
| 1964-08-28 | vs LAN | 127 | W 5-3 | 69-58 | 4 | 20,180 | Ray Sadecki | Phil Ortega | Ray Sadecki | Phil Ortega | | 546 | 523 | 23 |
| 1964-08-29 | vs LAN | 128 | W 4-1 | 70-58 | 4 | 20,001 | Bob Gibson | Howie Reed | Bob Gibson | Howie Reed | | 550 | 524 | 26 |
| 1964-08-30 | vs LAN | 129 | W 5-1 | 71-58 | 4 | 24,766 | Curt Simmons | Larry Miller | Curt Simmons | Larry Miller | | 555 | 525 | 30 |
| 1964-08-31 | vs LAN | 130 | L 3-12 | 71-59 | 4 | 16,387 | Mike Cuellar | Don Drysdale | Don Drysdale | Mike Cuellar | | 558 | 537 | 21 |
| 1964-09-01 | vs MLN | 131 | W 5-4 | 72-59 | 3 | 8,079 | Ray Sadecki | Denny Lemaster | Ron Taylor | Denny Lemaster | | 563 | 541 | 22 |
| 1964-09-02 | vs MLN | 132 | W 6-2 | 73-59 | 3 | 8,369 | Bob Gibson | Hank Fischer | Bob Gibson | Hank Fischer | | 569 | 543 | 26 |
| 1964-09-03 | vs MLN | 133 | L 0-7 | 73-60 | 4 | 8,221 | Roger Craig | Wade Blasingame | Wade Blasingame | Roger Craig | | 569 | 550 | 19 |
| 1964-09-04 | vs CHN | 134 | W 8-5 | 74-60 | 3 | 10,220 | Curt Simmons | Dick Ellsworth | Gordie Richardson | Don Elston | | 577 | 555 | 22 |
| 1964-09-05 | vs CHN | 135 | L 5-8 | 74-61 | 3 | 12,185 | Mike Cuellar | Larry Jackson | Larry Jackson | Mike Cuellar | Lindy McDaniel | 582 | 563 | 19 |
| 1964-09-06 | vs CHN | 136 | W 5-4 | 75-61 | 3 | 16,161 | Ray Sadecki | Ernie Broglio | Bob Humphreys | Lindy McDaniel | | 587 | 567 | 20 |
| 1964-09-07 | vs CIN | 137 | W 3-2 | 77-61 | 3 | 0 | Bob Gibson | Jim O'Toole | Bob Gibson | Bill Henry | | 590 | 569 | 21 |
| 1964-09-07 | vs CIN | 138 | W 3-2 | 77-61 | 3 | 22,187 | Roger Craig | John Tsitouris | Barney Schultz | Joe Nuxhall | | 593 | 571 | 22 |
| 1964-09-09 | @ PHI | 139 | W 10-5 | 78-61 | 2 | 25,339 | Curt Simmons | Jim Bunning | Bob Humphreys | Jack Baldschun | | 603 | 576 | 27 |
| 1964-09-10 | @ PHI | 140 | L 1-5 | 78-62 | 3 | 14,552 | Ray Sadecki | Chris Short | Chris Short | Ray Sadecki | | 604 | 581 | 23 |
| 1964-09-11 | @ CHN | 141 | W 5-0 | 79-62 | 2 | 2,240 | Bob Gibson | Ernie Broglio | Bob Gibson | Ernie Broglio | | 609 | 581 | 28 |
| 1964-09-12 | @ CHN | 142 | L 2-3 | 79-63 | 2 | 8,330 | Roger Craig | Bob Buhl | Bob Buhl | Roger Craig | | 611 | 584 | 27 |
| 1964-09-13 | @ CHN | 143 | W 15-2 | 80-63 | 2 | 11,606 | Curt Simmons | Dick Ellsworth | Curt Simmons | Dick Ellsworth | Ray Washburn | 626 | 586 | 40 |
| 1964-09-15 | @ MLN | 144 | W 11-6 | 82-63 | 2 | 0 | Ray Sadecki | Tony Cloninger | Ray Sadecki | Tony Cloninger | Barney Schultz | 637 | 592 | 45 |
| 1964-09-15 | @ MLN | 145 | W 3-1 | 82-63 | 2 | 5,843 | Bob Gibson | Wade Blasingame | Bob Gibson | Wade Blasingame | | 640 | 593 | 47 |
| 1964-09-16 | @ MLN | 146 | L 2-3 | 82-64 | 2 | 3,019 | Ron Taylor | Denny Lemaster | Denny Lemaster | Ron Taylor | Bobby Tiefenauer | 642 | 596 | 46 |
| 1964-09-19 | @ CIN | 147 | L 5-7 | 83-65 | 2 | 0 | Bob Gibson | Bob Purkey | Sammy Ellis | Bob Gibson | | 647 | 603 | 44 |
| 1964-09-19 | @ CIN | 148 | W 2-0 | 83-65 | 2 | 13,221 | Ray Sadecki | Billy McCool | Ray Sadecki | Billy McCool | Barney Schultz | 649 | 603 | 46 |
| 1964-09-20 | @ CIN | 149 | L 6-9 | 83-66 | 3 | 11,544 | Gordie Richardson | Joe Nuxhall | Sammy Ellis | Barney Schultz | | 655 | 612 | 43 |
| 1964-09-22 | @ NYN | 150 | W 2-1 | 84-66 | 3 | 10,443 | Curt Simmons | Tracy Stallard | Curt Simmons | Tracy Stallard | | 657 | 613 | 44 |
| 1964-09-23 | @ NYN | 151 | L 1-2 | 84-67 | 3 | 3,941 | Roger Craig | Galen Cisco | Galen Cisco | Roger Craig | Willard Hunter | 658 | 615 | 43 |
| 1964-09-24 | @ PIT | 152 | W 4-2 | 86-67 | 3 | 0 | Bob Gibson | Wilbur Wood | Bob Gibson | Wilbur Wood | | 662 | 617 | 45 |
| 1964-09-24 | @ PIT | 153 | W 4-0 | 86-67 | 3 | 2,846 | Ray Sadecki | Tom Butters | Ray Sadecki | Tom Butters | | 666 | 617 | 49 |
| 1964-09-25 | @ PIT | 154 | W 5-3 | 87-67 | 3 | 3,694 | Gordie Richardson | Don Cardwell | Gordie Richardson | Don Cardwell | Barney Schultz | 671 | 620 | 51 |
| 1964-09-26 | @ PIT | 155 | W 6-3 | 88-67 | 3 | 4,085 | Curt Simmons | Bob Veale | Curt Simmons | Bob Veale | Barney Schultz | 677 | 623 | 54 |
| 1964-09-27 | @ PIT | 156 | W 5-0 | 89-67 | 3 | 19,287 | Roger Craig | Vern Law | Roger Craig | Vern Law | Barney Schultz | 682 | 623 | 59 |
| 1964-09-28 | vs PHI | 157 | W 5-1 | 90-67 | 2 | 24,146 | Bob Gibson | Chris Short | Bob Gibson | Chris Short | Barney Schultz | 687 | 624 | 63 |
| 1964-09-29 | vs PHI | 158 | W 4-2 | 91-67 | 2 | 27,433 | Ray Sadecki | Dennis Bennett | Ray Sadecki | Dennis Bennett | Barney Schultz | 691 | 626 | 65 |
| 1964-09-30 | vs PHI | 159 | W 8-5 | 92-67 | 1 | 29,920 | Curt Simmons | Jim Bunning | Curt Simmons | Jim Bunning | Gordie Richardson | 699 | 631 | 68 |
| 1964-10-02 | vs NYN | 160 | L 0-1 | 92-68 | 1 | 19,019 | Bob Gibson | Al Jackson | Al Jackson | Bob Gibson | | 699 | 632 | 67 |
| 1964-10-03 | vs NYN | 161 | L 5-15 | 92-69 | 2 | 18,650 | Ray Sadecki | Jack Fisher | Tom Parsons | Ray Sadecki | | 704 | 647 | 57 |
| 1964-10-04 | vs NYN | 162 | W 11-5 | 93-69 | 1 | 30,146 | Curt Simmons | Galen Cisco | Bob Gibson | Galen Cisco | Barney Schultz | 715 | 652 | 63 |