| 1961-04-11 | @ CIN | 1 | L 1-7 | 0-1 | 5 | 28,713 | Glen Hobbie | Jim O'Toole | Jim O'Toole | Glen Hobbie | | 1 | 7 | -6 |
| 1961-04-13 | @ CIN | 2 | L 2-5 | 0-2 | 8 | 1,216 | Dick Ellsworth | Bob Purkey | Bob Purkey | Joe Schaffernoth | | 3 | 12 | -9 |
| 1961-04-14 | vs MLN | 3 | W 3-2 | 1-2 | 5 | 11,299 | Bob Anderson | Bob Buhl | Don Elston | Bob Buhl | | 6 | 14 | -8 |
| 1961-04-15 | vs MLN | 4 | W 9-5 | 2-2 | 4 | 6,207 | Glen Hobbie | Carl Willey | Don Elston | Don Nottebart | | 15 | 19 | -4 |
| 1961-04-18 | @ PIT | 5 | L 3-5 | 2-3 | 6 | 30,781 | Dick Ellsworth | Vinegar Bend Mizell | Vinegar Bend Mizell | Mel Wright | Roy Face | 18 | 24 | -6 |
| 1961-04-19 | @ PIT | 6 | L 1-4 | 2-4 | 6 | 12,742 | Bob Anderson | Bob Friend | Bob Friend | Bob Anderson | | 19 | 28 | -9 |
| 1961-04-20 | @ PIT | 7 | W 3-0 | 3-4 | 6 | 10,428 | Glen Hobbie | Joe Gibbon | Glen Hobbie | Joe Gibbon | | 22 | 28 | -6 |
| 1961-04-21 | @ PHI | 8 | W 3-2 | 4-4 | 6 | 5,738 | Don Cardwell | Robin Roberts | Don Cardwell | Robin Roberts | Don Elston | 25 | 30 | -5 |
| 1961-04-22 | @ PHI | 9 | W 6-4 | 5-4 | 2 | 3,996 | Jack Curtis | Chris Short | Don Elston | Turk Farrell | | 31 | 34 | -3 |
| 1961-04-23 | @ PHI | 10 | L 0-1 | 5-6 | 6 | 0 | Dick Ellsworth | Frank Sullivan | Frank Sullivan | Dick Ellsworth | | 31 | 35 | -4 |
| 1961-04-23 | @ PHI | 11 | L 0-6 | 5-6 | 6 | 16,027 | Bob Anderson | Art Mahaffey | Art Mahaffey | Bob Anderson | | 31 | 41 | -10 |
| 1961-04-26 | vs CIN | 12 | W 3-2 | 6-6 | 5 | 5,116 | Glen Hobbie | Jim O'Toole | Don Elston | Jim Maloney | | 34 | 43 | -9 |
| 1961-04-27 | vs CIN | 13 | W 5-2 | 7-6 | 4 | 2,463 | Don Cardwell | Ken Hunt | Don Cardwell | Ken Hunt | Don Elston | 39 | 45 | -6 |
| 1961-04-29 | vs LAN | 14 | L 4-9 | 7-7 | 5 | 9,842 | Dick Ellsworth | Johnny Podres | Johnny Podres | Dick Ellsworth | | 43 | 54 | -11 |
| 1961-04-30 | vs LAN | 15 | L 1-2 | 8-8 | 4 | 0 | Glen Hobbie | Don Drysdale | Larry Sherry | Glen Hobbie | | 44 | 56 | -12 |
| 1961-04-30 | vs LAN | 16 | W 10-5 | 8-8 | 4 | 20,529 | Bob Anderson | Roger Craig | Bob Anderson | Roger Craig | Don Elston | 54 | 61 | -7 |
| 1961-05-02 | vs SFN | 17 | W 9-4 | 9-8 | 4 | 3,334 | Don Cardwell | Jack Sanford | Don Cardwell | Jack Sanford | | 63 | 65 | -2 |
| 1961-05-03 | vs SFN | 18 | L 4-8 | 9-9 | 4 | 4,512 | Jack Curtis | Mike McCormick | Billy O'Dell | Jack Curtis | Bobby Bolin | 67 | 73 | -6 |
| 1961-05-04 | vs SFN | 19 | L 3-9 | 9-10 | 6 | 3,658 | Glen Hobbie | Sam Jones | Sam Jones | Glen Hobbie | | 70 | 82 | -12 |
| 1961-05-06 | @ SLN | 20 | L 1-6 | 9-11 | 7 | 6,671 | Jim Brewer | Ray Sadecki | Ray Sadecki | Jim Brewer | | 71 | 88 | -17 |
| 1961-05-07 | @ SLN | 21 | L 2-4 | 9-12 | 7 | 15,299 | Don Cardwell | Ernie Broglio | Ernie Broglio | Don Cardwell | | 73 | 92 | -19 |
| 1961-05-09 | @ MLN | 22 | L 5-8 | 9-13 | 7 | 8,391 | Glen Hobbie | Bob Buhl | Bob Buhl | Glen Hobbie | | 78 | 100 | -22 |
| 1961-05-10 | @ MLN | 23 | L 2-3 | 9-14 | 7 | 9,132 | Dick Ellsworth | Lew Burdette | Lew Burdette | Don Elston | | 80 | 103 | -23 |
| 1961-05-12 | @ LAN | 24 | L 2-4 | 9-15 | 7 | 17,122 | Don Cardwell | Sandy Koufax | Sandy Koufax | Don Cardwell | Turk Farrell | 82 | 107 | -25 |
| 1961-05-13 | @ LAN | 25 | L 3-7 | 9-16 | 7 | 22,463 | Bob Anderson | Stan Williams | Ron Perranoski | Bob Anderson | | 85 | 114 | -29 |
| 1961-05-14 | @ LAN | 26 | W 10-8 | 10-16 | 7 | 21,733 | Glen Hobbie | Don Drysdale | Don Elston | Turk Farrell | | 95 | 122 | -27 |
| 1961-05-15 | @ SFN | 27 | L 1-14 | 10-17 | 7 | 8,013 | Dick Ellsworth | Mike McCormick | Mike McCormick | Dick Ellsworth | | 96 | 136 | -40 |
| 1961-05-16 | @ SFN | 28 | L 1-2 | 10-18 | 7 | 11,596 | Dick Drott | Jack Sanford | Jack Sanford | Dick Drott | | 97 | 138 | -41 |
| 1961-05-17 | @ SFN | 29 | L 3-4 | 10-19 | 7 | 8,469 | Don Cardwell | Sam Jones | Stu Miller | Don Elston | | 100 | 142 | -42 |
| 1961-05-19 | vs SLN | 30 | W 1-0 | 11-19 | 7 | 3,192 | Glen Hobbie | Ray Sadecki | Glen Hobbie | Ray Sadecki | | 101 | 142 | -41 |
| 1961-05-20 | vs SLN | 31 | W 1-0 | 12-19 | 7 | 9,103 | Dick Ellsworth | Larry Jackson | Dick Ellsworth | Larry Jackson | | 102 | 142 | -40 |
| 1961-05-21 | vs SLN | 32 | L 3-6 | 12-21 | 7 | 0 | Don Cardwell | Curt Simmons | Lindy McDaniel | Don Elston | | 105 | 148 | -43 |
| 1961-05-21 | vs SLN | 33 | L 0-3 | 12-21 | 7 | 18,222 | Dick Drott | Bob Gibson | Bob Gibson | Joe Schaffernoth | | 105 | 151 | -46 |
| 1961-05-23 | vs PHI | 34 | L 1-2 | 12-22 | 7 | 2,179 | Glen Hobbie | Frank Sullivan | Frank Sullivan | Glen Hobbie | Chris Short | 106 | 153 | -47 |
| 1961-05-24 | vs PIT | 35 | L 3-7 | 12-23 | 7 | 5,573 | Dick Ellsworth | Vinegar Bend Mizell | Vinegar Bend Mizell | Dick Ellsworth | Clem Labine | 109 | 160 | -51 |
| 1961-05-26 | vs SFN | 36 | L 2-3 | 12-24 | 7 | 1,286 | Don Cardwell | Juan Marichal | Sam Jones | Don Elston | Eddie Fisher | 111 | 163 | -52 |
| 1961-05-27 | vs SFN | 37 | L 2-8 | 12-25 | 7 | 9,818 | Dick Drott | Billy Loes | Billy Loes | Dick Drott | Stu Miller | 113 | 171 | -58 |
| 1961-05-28 | vs SFN | 38 | L 5-6 | 12-26 | 7 | 13,309 | Glen Hobbie | Jack Sanford | Stu Miller | Jim Brewer | Bobby Bolin | 118 | 177 | -59 |
| 1961-05-30 | @ PIT | 39 | W 5-3 | 14-26 | 7 | 0 | Dick Ellsworth | Vinegar Bend Mizell | Dick Ellsworth | Vinegar Bend Mizell | Don Elston | 123 | 180 | -57 |
| 1961-05-30 | @ PIT | 40 | W 10-0 | 14-26 | 7 | 30,852 | Don Cardwell | Bob Friend | Don Cardwell | Bob Friend | | 133 | 180 | -47 |
| 1961-05-31 | @ PHI | 41 | W 5-4 | 15-26 | 7 | 4,213 | Dick Drott | Robin Roberts | Bob Anderson | Robin Roberts | Don Elston | 138 | 184 | -46 |
| 1961-06-01 | @ PHI | 42 | W 10-3 | 16-26 | 7 | 3,785 | Glen Hobbie | Frank Sullivan | Glen Hobbie | Frank Sullivan | | 148 | 187 | -39 |
| 1961-06-02 | @ CIN | 43 | W 7-6 | 17-26 | 7 | 12,656 | Jack Curtis | Bob Purkey | Jack Curtis | Bob Purkey | Don Elston | 155 | 193 | -38 |
| 1961-06-03 | @ CIN | 44 | W 10-7 | 18-26 | 7 | 5,756 | Dick Ellsworth | Ken Hunt | Glen Hobbie | Jim Brosnan | | 165 | 200 | -35 |
| 1961-06-04 | @ CIN | 45 | L 1-3 | 19-27 | 7 | 0 | Bob Anderson | Jim Maloney | Jim Maloney | Bob Anderson | | 166 | 203 | -37 |
| 1961-06-04 | @ CIN | 46 | W 8-2 | 19-27 | 7 | 19,262 | Don Cardwell | Jim O'Toole | Don Cardwell | Jim O'Toole | | 174 | 205 | -31 |
| 1961-06-05 | @ SLN | 47 | L 8-10 | 19-28 | 7 | 7,789 | Dick Ellsworth | Curt Simmons | Mickey McDermott | Joe Schaffernoth | | 182 | 215 | -33 |
| 1961-06-06 | @ SLN | 48 | L 2-6 | 19-30 | 7 | 0 | Glen Hobbie | Ernie Broglio | Ernie Broglio | Glen Hobbie | | 184 | 221 | -37 |
| 1961-06-06 | @ SLN | 49 | L 3-3 | 19-30 | 7 | 14,690 | Jack Curtis | Ray Sadecki | | | | 187 | 224 | -37 |
| 1961-06-07 | @ SLN | 50 | L 6-8 | 19-31 | 7 | 6,182 | Bob Anderson | Larry Jackson | Larry Jackson | Bob Anderson | Mickey McDermott | 193 | 232 | -39 |
| 1961-06-09 | vs MLN | 51 | W 11-10 | 20-31 | 7 | 7,912 | Don Cardwell | Bob Buhl | Bob Anderson | Warren Spahn | | 204 | 242 | -38 |
| 1961-06-10 | vs MLN | 52 | L 5-9 | 20-32 | 7 | 18,127 | Glen Hobbie | Lew Burdette | Don McMahon | Glen Hobbie | | 209 | 251 | -42 |
| 1961-06-11 | vs MLN | 53 | L 4-8 | 21-33 | 7 | 0 | Dick Ellsworth | Carl Willey | Warren Spahn | Joe Schaffernoth | | 213 | 259 | -46 |
| 1961-06-11 | vs MLN | 54 | W 5-3 | 21-33 | 7 | 34,599 | Jack Curtis | Don Nottebart | Jack Curtis | Don Nottebart | Barney Schultz | 218 | 262 | -44 |
| 1961-06-14 | @ LAN | 55 | L 0-7 | 21-34 | 7 | 13,528 | Don Cardwell | Don Drysdale | Don Drysdale | Don Cardwell | | 218 | 269 | -51 |
| 1961-06-15 | @ LAN | 56 | L 3-6 | 21-35 | 7 | 13,348 | Glen Hobbie | Johnny Podres | Turk Farrell | Barney Schultz | | 221 | 275 | -54 |
| 1961-06-16 | @ SFN | 57 | W 12-6 | 22-35 | 7 | 20,622 | Dick Ellsworth | Billy Loes | Bob Anderson | Billy Loes | Barney Schultz | 233 | 281 | -48 |
| 1961-06-17 | @ SFN | 58 | L 3-9 | 22-36 | 7 | 16,443 | Jack Curtis | Billy O'Dell | Billy O'Dell | Jack Curtis | | 236 | 290 | -54 |
| 1961-06-18 | @ SFN | 59 | L 2-7 | 22-37 | 7 | 27,241 | Don Cardwell | Juan Marichal | Juan Marichal | Don Cardwell | Dick LeMay | 238 | 297 | -59 |
| 1961-06-20 | vs LAN | 60 | L 0-3 | 22-38 | 7 | 5,868 | Glen Hobbie | Sandy Koufax | Sandy Koufax | Glen Hobbie | | 238 | 300 | -62 |
| 1961-06-21 | vs LAN | 61 | L 1-4 | 22-40 | 7 | 0 | Dick Ellsworth | Stan Williams | Stan Williams | Dick Ellsworth | Larry Sherry | 239 | 304 | -65 |
| 1961-06-21 | vs LAN | 62 | L 2-4 | 22-40 | 7 | 12,364 | Don Cardwell | Johnny Podres | Johnny Podres | Don Cardwell | Larry Sherry | 241 | 308 | -67 |
| 1961-06-22 | vs LAN | 63 | W 7-5 | 23-40 | 7 | 4,821 | Dick Drott | Roger Craig | Barney Schultz | Turk Farrell | | 248 | 313 | -65 |
| 1961-06-23 | @ MLN | 64 | W 5-3 | 24-40 | 7 | 20,202 | Jack Curtis | Bob Hendley | Jack Curtis | Bob Hendley | Barney Schultz | 253 | 316 | -63 |
| 1961-06-24 | @ MLN | 65 | L 4-13 | 24-41 | 7 | 20,988 | Glen Hobbie | Tony Cloninger | Tony Cloninger | Glen Hobbie | Claude Raymond | 257 | 329 | -72 |
| 1961-06-25 | @ MLN | 66 | W 5-3 | 25-41 | 7 | 25,454 | Don Cardwell | Warren Spahn | Don Cardwell | Warren Spahn | Barney Schultz | 262 | 332 | -70 |
| 1961-06-27 | vs CIN | 67 | L 8-10 | 25-42 | 7 | 7,849 | Dick Ellsworth | Ken Hunt | Jay Hook | Bob Anderson | Sherman Jones | 270 | 342 | -72 |
| 1961-06-28 | vs CIN | 68 | W 16-5 | 27-42 | 7 | 0 | Glen Hobbie | Bob Purkey | Glen Hobbie | Bob Purkey | | 286 | 347 | -61 |
| 1961-06-28 | vs CIN | 69 | W 7-2 | 27-42 | 7 | 12,785 | Jack Curtis | Jim O'Toole | Jack Curtis | Jim O'Toole | | 293 | 349 | -56 |
| 1961-06-29 | vs CIN | 70 | W 15-8 | 28-42 | 7 | 7,925 | Don Cardwell | Jim Maloney | Don Cardwell | Jim Maloney | Don Elston | 308 | 357 | -49 |
| 1961-06-30 | vs SLN | 71 | L 4-11 | 28-43 | 7 | 5,122 | Jim Brewer | Ray Sadecki | Ray Sadecki | Jim Brewer | Lindy McDaniel | 312 | 368 | -56 |
| 1961-07-01 | vs SLN | 72 | W 13-1 | 29-43 | 7 | 12,333 | Dick Ellsworth | Bob Miller | Dick Ellsworth | Bob Miller | | 325 | 369 | -44 |
| 1961-07-02 | vs SLN | 73 | W 10-9 | 30-43 | 7 | 18,447 | Glen Hobbie | Al Cicotte | Barney Schultz | Ernie Broglio | Bob Anderson | 335 | 378 | -43 |
| 1961-07-04 | vs SFN | 74 | L 3-19 | 31-44 | 7 | 0 | Don Cardwell | Eddie Fisher | Billy O'Dell | Don Cardwell | | 338 | 397 | -59 |
| 1961-07-04 | vs SFN | 75 | W 3-2 | 31-44 | 7 | 25,505 | Jack Curtis | Billy Loes | Jack Curtis | Dick LeMay | Bob Anderson | 341 | 399 | -58 |
| 1961-07-06 | vs PIT | 76 | L 3-15 | 32-45 | 7 | 0 | Dick Ellsworth | Bob Friend | Bob Friend | Dick Ellsworth | | 344 | 414 | -70 |
| 1961-07-06 | vs PIT | 77 | W 5-1 | 32-45 | 7 | 15,813 | Glen Hobbie | Vinegar Bend Mizell | Glen Hobbie | Vinegar Bend Mizell | | 349 | 415 | -66 |
| 1961-07-07 | vs PHI | 78 | W 9-3 | 33-45 | 7 | 5,356 | Don Cardwell | Chris Short | Don Cardwell | Chris Short | | 358 | 418 | -60 |
| 1961-07-08 | vs PHI | 79 | W 6-4 | 34-45 | 7 | 11,645 | Jack Curtis | Jim Owens | Jack Curtis | Jim Owens | Barney Schultz | 364 | 422 | -58 |
| 1961-07-09 | vs PHI | 80 | W 9-8 | 36-45 | 7 | 0 | Glen Hobbie | Art Mahaffey | Glen Hobbie | Art Mahaffey | Bob Anderson | 373 | 430 | -57 |
| 1961-07-09 | vs PHI | 81 | W 8-5 | 36-45 | 7 | 20,556 | Jim Brewer | Frank Sullivan | Dick Ellsworth | Chris Short | | 381 | 435 | -54 |
| 1961-07-13 | @ CIN | 82 | L 3-4 | 36-46 | 7 | 14,601 | Don Cardwell | Jim O'Toole | Jim O'Toole | Don Cardwell | | 384 | 439 | -55 |
| 1961-07-14 | @ CIN | 83 | W 8-7 | 37-46 | 7 | 16,364 | Glen Hobbie | Bob Purkey | Barney Schultz | Jim Brosnan | Don Elston | 392 | 446 | -54 |
| 1961-07-15 | @ CIN | 84 | L 1-2 | 37-47 | 7 | 24,201 | Jack Curtis | Joey Jay | Joey Jay | Jack Curtis | | 393 | 448 | -55 |
| 1961-07-16 | @ CIN | 85 | W 4-2 | 38-47 | 7 | 16,617 | Dick Ellsworth | Ken Hunt | Dick Ellsworth | Ken Hunt | Bob Anderson | 397 | 450 | -53 |
| 1961-07-17 | @ SLN | 86 | L 6-10 | 38-49 | 7 | 0 | Don Cardwell | Curt Simmons | Curt Simmons | Don Elston | Lindy McDaniel | 403 | 460 | -57 |
| 1961-07-17 | @ SLN | 87 | L 5-8 | 38-49 | 7 | 13,647 | Jim Brewer | Ernie Broglio | Ernie Broglio | Jim Brewer | Lindy McDaniel | 408 | 468 | -60 |
| 1961-07-18 | @ SLN | 88 | L 3-8 | 38-51 | 7 | 0 | Glen Hobbie | Larry Jackson | Larry Jackson | Glen Hobbie | | 411 | 476 | -65 |
| 1961-07-18 | @ SLN | 89 | L 5-7 | 38-51 | 7 | 12,889 | Dick Drott | Bob Gibson | Bob Gibson | Bob Anderson | | 416 | 483 | -67 |
| 1961-07-20 | @ PIT | 90 | L 0-4 | 38-52 | 7 | 13,859 | Jack Curtis | Joe Gibbon | Joe Gibbon | Jack Curtis | | 416 | 487 | -71 |
| 1961-07-21 | @ PHI | 91 | L 3-4 | 38-53 | 7 | 5,413 | Don Cardwell | Jim Owens | Jack Baldschun | Barney Schultz | | 419 | 491 | -72 |
| 1961-07-22 | @ PHI | 92 | L 5-6 | 38-54 | 7 | 2,956 | Glen Hobbie | Chris Short | Chris Short | Glen Hobbie | Jack Baldschun | 424 | 497 | -73 |
| 1961-07-23 | @ PHI | 93 | W 11-5 | 39-54 | 7 | 3,476 | Jim Brewer | Art Mahaffey | Don Elston | Art Mahaffey | | 435 | 502 | -67 |
| 1961-07-25 | vs SLN | 94 | L 5-6 | 39-55 | 7 | 13,326 | Jack Curtis | Ray Sadecki | Ray Sadecki | Jack Curtis | Lindy McDaniel | 440 | 508 | -68 |
| 1961-07-26 | vs SLN | 95 | W 7-6 | 40-55 | 7 | 11,249 | Don Cardwell | Curt Simmons | Barney Schultz | Lindy McDaniel | | 447 | 514 | -67 |
| 1961-07-27 | vs SLN | 96 | W 3-2 | 41-55 | 7 | 8,219 | Glen Hobbie | Al Cicotte | Barney Schultz | Bob Gibson | | 450 | 516 | -66 |
| 1961-07-28 | vs CIN | 97 | L 3-4 | 41-56 | 7 | 6,394 | Dick Ellsworth | Jim O'Toole | Jim O'Toole | Dick Ellsworth | Bill Henry | 453 | 520 | -67 |
| 1961-07-29 | vs CIN | 98 | W 7-6 | 42-56 | 7 | 16,452 | Jack Curtis | Joey Jay | Jack Curtis | Joey Jay | Barney Schultz | 460 | 526 | -66 |
| 1961-07-30 | vs CIN | 99 | W 3-2 | 43-57 | 7 | 0 | Don Cardwell | Ken Hunt | Don Cardwell | Ken Hunt | | 463 | 528 | -65 |
| 1961-07-30 | vs CIN | 100 | L 4-5 | 43-57 | 7 | 29,929 | Jim Brewer | Ken Johnson | Jim Maloney | Jim Brewer | Jim O'Toole | 467 | 533 | -66 |
| 1961-08-02 | vs MLN | 101 | L 2-4 | 44-58 | 7 | 0 | Glen Hobbie | Carl Willey | Carl Willey | Glen Hobbie | | 469 | 537 | -68 |
| 1961-08-02 | vs MLN | 102 | W 7-7 | 44-58 | 7 | 19,587 | Jack Curtis | Bob Buhl | | | | 476 | 544 | -68 |
| 1961-08-03 | vs MLN | 103 | L 2-5 | 44-59 | 7 | 11,556 | Don Cardwell | Lew Burdette | Lew Burdette | Don Cardwell | | 478 | 549 | -71 |
| 1961-08-04 | @ LAN | 104 | W 4-2 | 45-59 | 7 | 15,154 | Bob Anderson | Sandy Koufax | Bob Anderson | Sandy Koufax | Barney Schultz | 482 | 551 | -69 |
| 1961-08-05 | @ LAN | 105 | L 6-7 | 45-60 | 7 | 43,247 | Jim Brewer | Don Drysdale | Larry Sherry | Don Cardwell | | 488 | 558 | -70 |
| 1961-08-06 | @ LAN | 106 | L 4-11 | 45-61 | 7 | 11,078 | Jack Curtis | Johnny Podres | Johnny Podres | Jack Curtis | | 492 | 569 | -77 |
| 1961-08-08 | @ SFN | 107 | L 1-8 | 45-62 | 7 | 10,977 | Don Cardwell | Jack Sanford | Jack Sanford | Don Cardwell | | 493 | 577 | -84 |
| 1961-08-09 | @ SFN | 108 | L 5-6 | 45-63 | 7 | 10,822 | Bob Anderson | Mike McCormick | Stu Miller | Barney Schultz | | 498 | 583 | -85 |
| 1961-08-11 | @ MLN | 109 | L 1-2 | 45-64 | 7 | 40,775 | Jack Curtis | Warren Spahn | Warren Spahn | Jack Curtis | | 499 | 585 | -86 |
| 1961-08-12 | @ MLN | 110 | L 6-8 | 45-65 | 7 | 19,859 | Don Cardwell | Bob Hendley | Don McMahon | Dick Drott | | 505 | 593 | -88 |
| 1961-08-13 | @ MLN | 111 | L 3-8 | 45-66 | 7 | 21,485 | Bob Anderson | Lew Burdette | Lew Burdette | Bob Anderson | | 508 | 601 | -93 |
| 1961-08-14 | vs PHI | 112 | W 9-2 | 46-66 | 7 | 5,608 | Dick Ellsworth | Frank Sullivan | Dick Ellsworth | Frank Sullivan | | 517 | 603 | -86 |
| 1961-08-15 | vs PHI | 113 | W 6-5 | 47-66 | 7 | 5,878 | Jack Curtis | Art Mahaffey | Jack Curtis | Art Mahaffey | Bob Anderson | 523 | 608 | -85 |
| 1961-08-16 | vs PHI | 114 | W 9-5 | 48-66 | 7 | 6,390 | Don Cardwell | Chris Short | Don Cardwell | Chris Short | | 532 | 613 | -81 |
| 1961-08-17 | vs PIT | 115 | W 11-4 | 49-67 | 7 | 0 | Glen Hobbie | Vinegar Bend Mizell | Dick Drott | Vinegar Bend Mizell | Bob Anderson | 543 | 617 | -74 |
| 1961-08-17 | vs PIT | 116 | L 3-4 | 49-67 | 7 | 16,961 | Jim Brewer | Earl Francis | Earl Francis | Jim Brewer | Roy Face | 546 | 621 | -75 |
| 1961-08-18 | vs PIT | 117 | W 2-1 | 50-67 | 7 | 7,469 | Dick Ellsworth | Tom Sturdivant | Dick Ellsworth | Tom Sturdivant | | 548 | 622 | -74 |
| 1961-08-19 | vs PIT | 118 | L 3-4 | 50-68 | 7 | 11,777 | Jack Curtis | Harvey Haddix | Clem Labine | Jack Curtis | | 551 | 626 | -75 |
| 1961-08-20 | vs PIT | 119 | W 1-0 | 51-68 | 7 | 19,038 | Don Cardwell | Bob Friend | Don Cardwell | Bob Friend | | 552 | 626 | -74 |
| 1961-08-22 | @ PHI | 120 | L 0-6 | 51-69 | 7 | 4,957 | Dick Ellsworth | Art Mahaffey | Art Mahaffey | Dick Ellsworth | | 552 | 632 | -80 |
| 1961-08-24 | @ PHI | 121 | L 4-7 | 51-70 | 7 | 2,773 | Jack Curtis | Jim Owens | Jim Owens | Jack Curtis | Don Ferrarese | 556 | 639 | -83 |
| 1961-08-25 | @ PIT | 122 | L 0-1 | 51-71 | 7 | 12,651 | Don Cardwell | Tom Sturdivant | Tom Sturdivant | Don Cardwell | | 556 | 640 | -84 |
| 1961-08-26 | @ PIT | 123 | W 7-3 | 52-71 | 7 | 9,137 | Dick Ellsworth | Harvey Haddix | Barney Schultz | Roy Face | Bob Anderson | 563 | 643 | -80 |
| 1961-08-27 | @ PIT | 124 | L 3-7 | 53-72 | 7 | 0 | Jack Curtis | Joe Gibbon | Joe Gibbon | Jack Curtis | Clem Labine | 566 | 650 | -84 |
| 1961-08-27 | @ PIT | 125 | W 6-5 | 53-72 | 7 | 15,471 | Jim Brewer | Vinegar Bend Mizell | Jim Brewer | Vinegar Bend Mizell | Bob Anderson | 572 | 655 | -83 |
| 1961-08-28 | @ PIT | 126 | W 5-4 | 54-72 | 7 | 13,753 | Dick Drott | Earl Francis | Bob Anderson | Roy Face | | 577 | 659 | -82 |
| 1961-08-29 | vs LAN | 127 | L 1-2 | 54-73 | 7 | 14,578 | Don Cardwell | Sandy Koufax | Sandy Koufax | Don Cardwell | | 578 | 661 | -83 |
| 1961-08-30 | vs LAN | 128 | L 2-5 | 54-74 | 7 | 11,292 | Dick Ellsworth | Johnny Podres | Johnny Podres | Dick Ellsworth | Larry Sherry | 580 | 666 | -86 |
| 1961-08-31 | vs SFN | 129 | W 6-1 | 55-74 | 7 | 7,593 | Jack Curtis | Juan Marichal | Jack Curtis | Juan Marichal | | 586 | 667 | -81 |
| 1961-09-01 | vs SFN | 130 | L 3-4 | 55-75 | 7 | 5,427 | Glen Hobbie | Dick LeMay | Billy Loes | Don Elston | | 589 | 671 | -82 |
| 1961-09-02 | vs SFN | 131 | W 7-0 | 56-75 | 7 | 9,547 | Don Cardwell | Jack Sanford | Don Cardwell | Jack Sanford | | 596 | 671 | -75 |
| 1961-09-03 | vs MLN | 132 | W 6-5 | 57-76 | 7 | 0 | Jim Brewer | Lew Burdette | Barney Schultz | Lew Burdette | Glen Hobbie | 602 | 676 | -74 |
| 1961-09-03 | vs MLN | 133 | L 2-4 | 57-76 | 7 | 22,706 | Dick Ellsworth | Tony Cloninger | Tony Cloninger | Dick Ellsworth | | 604 | 680 | -76 |
| 1961-09-04 | vs MLN | 134 | W 6-2 | 58-76 | 7 | 16,230 | Jack Curtis | Carl Willey | Jack Curtis | Carl Willey | | 610 | 682 | -72 |
| 1961-09-05 | vs PIT | 135 | L 3-8 | 58-77 | 7 | 3,417 | Glen Hobbie | Tom Sturdivant | Tom Sturdivant | Glen Hobbie | | 613 | 690 | -77 |
| 1961-09-06 | vs PIT | 136 | W 6-2 | 59-77 | 7 | 3,080 | Don Cardwell | Joe Gibbon | Don Cardwell | Joe Gibbon | | 619 | 692 | -73 |
| 1961-09-07 | vs PIT | 137 | L 5-7 | 59-78 | 7 | 2,752 | Jim Brewer | Harvey Haddix | Bobby Shantz | Jim Brewer | | 624 | 699 | -75 |
| 1961-09-08 | vs PHI | 138 | W 4-1 | 60-78 | 7 | 1,533 | Dick Ellsworth | Art Mahaffey | Dick Ellsworth | Art Mahaffey | | 628 | 700 | -72 |
| 1961-09-09 | vs PHI | 139 | L 2-6 | 60-79 | 7 | 7,110 | Jack Curtis | Jim Owens | Jim Owens | Jack Curtis | | 630 | 706 | -76 |
| 1961-09-10 | vs PHI | 140 | L 6-14 | 60-80 | 7 | 7,628 | Don Cardwell | Robin Roberts | Don Ferrarese | Barney Schultz | Frank Sullivan | 636 | 720 | -84 |
| 1961-09-12 | @ CIN | 141 | L 2-7 | 60-81 | 7 | 12,487 | Dick Ellsworth | Jim O'Toole | Jim O'Toole | Dick Ellsworth | | 638 | 727 | -89 |
| 1961-09-14 | @ SLN | 142 | L 7-8 | 60-83 | 7 | 0 | Don Cardwell | Ernie Broglio | Ed Bauta | Barney Schultz | | 645 | 735 | -90 |
| 1961-09-14 | @ SLN | 143 | L 5-6 | 60-83 | 7 | 5,835 | Jack Curtis | Curt Simmons | Craig Anderson | Don Elston | | 650 | 741 | -91 |
| 1961-09-15 | @ SFN | 144 | L 1-5 | 60-84 | 7 | 9,850 | Dick Drott | Jack Sanford | Jack Sanford | Dick Drott | Stu Miller | 651 | 746 | -95 |
| 1961-09-16 | @ SFN | 145 | L 3-4 | 60-85 | 7 | 8,564 | Dick Ellsworth | Mike McCormick | Stu Miller | Bob Anderson | | 654 | 750 | -96 |
| 1961-09-17 | @ SFN | 146 | L 2-8 | 60-86 | 7 | 23,865 | Jack Curtis | Billy O'Dell | Billy O'Dell | Jack Curtis | | 656 | 758 | -102 |
| 1961-09-18 | @ LAN | 147 | W 5-3 | 61-86 | 7 | 10,409 | Don Cardwell | Phil Ortega | Don Cardwell | Phil Ortega | | 661 | 761 | -100 |
| 1961-09-19 | @ LAN | 148 | W 7-3 | 62-86 | 7 | 10,792 | Bob Anderson | Stan Williams | Bob Anderson | Stan Williams | | 668 | 764 | -96 |
| 1961-09-20 | @ LAN | 149 | L 2-3 | 62-87 | 7 | 12,068 | Dick Ellsworth | Sandy Koufax | Sandy Koufax | Barney Schultz | | 670 | 767 | -97 |
| 1961-09-23 | @ MLN | 150 | L 3-6 | 62-88 | 7 | 8,706 | Jack Curtis | Tony Cloninger | Tony Cloninger | Jack Curtis | | 673 | 773 | -100 |
| 1961-09-24 | @ MLN | 151 | L 0-8 | 63-89 | 7 | 0 | Don Cardwell | Warren Spahn | Warren Spahn | Don Cardwell | | 673 | 781 | -108 |
| 1961-09-24 | @ MLN | 152 | W 4-2 | 63-89 | 7 | 7,262 | Dick Ellsworth | Bob Hendley | Dick Ellsworth | Bob Hendley | Glen Hobbie | 677 | 783 | -106 |
| 1961-09-26 | vs CIN | 153 | L 3-6 | 63-90 | 7 | 3,327 | Bob Anderson | Bob Purkey | Jim Brosnan | Bob Anderson | | 680 | 789 | -109 |
| 1961-09-27 | vs SLN | 154 | W 5-2 | 64-90 | 7 | 1,558 | Don Cardwell | Larry Jackson | Don Cardwell | Larry Jackson | | 685 | 791 | -106 |
| 1961-09-30 | vs LAN | 155 | W 2-1 | 65-90 | 7 | 4,401 | Dick Ellsworth | Phil Ortega | Dick Ellsworth | Phil Ortega | | 687 | 792 | -105 |
| 1961-10-01 | vs LAN | 156 | L 2-8 | 65-91 | 7 | 4,325 | Don Cardwell | Stan Williams | Stan Williams | Don Cardwell | Ron Perranoski | 689 | 800 | -111 |