| 1961-04-11 | vs LAA | 1 | L 2-7 | 0-1 | 7 | 37,352 | Milt Pappas | Eli Grba | Eli Grba | Milt Pappas | | 2 | 7 | -5 |
| 1961-04-14 | vs MIN | 2 | L 2-3 | 0-2 | 10 | 9,185 | Jack Fisher | Camilo Pascual | Camilo Pascual | Jack Fisher | | 4 | 10 | -6 |
| 1961-04-15 | vs MIN | 3 | W 8-0 | 1-2 | 7 | 7,555 | Steve Barber | Chuck Stobbs | Steve Barber | Chuck Stobbs | | 12 | 10 | 2 |
| 1961-04-16 | vs MIN | 4 | L 5-10 | 1-4 | 9 | 0 | Chuck Estrada | Pedro Ramos | Pedro Ramos | Chuck Estrada | Ray Moore | 17 | 20 | -3 |
| 1961-04-16 | vs MIN | 5 | L 4-6 | 1-4 | 9 | 14,146 | Hal Brown | Jack Kralick | Bill Pleis | Billy Hoeft | Chuck Stobbs | 21 | 26 | -5 |
| 1961-04-21 | vs NYA | 6 | L 2-4 | 1-5 | 9 | 12,368 | Steve Barber | Whitey Ford | Whitey Ford | Steve Barber | | 23 | 30 | -7 |
| 1961-04-22 | vs NYA | 7 | W 5-3 | 3-5 | 8 | 12,536 | Jack Fisher | Ralph Terry | Hoyt Wilhelm | Ryne Duren | | 28 | 33 | -5 |
| 1961-04-22 | vs NYA | 8 | W 5-5 | 3-5 | 8 | 14,126 | Hal Brown | Jim Coates | | | | 33 | 38 | -5 |
| 1961-04-23 | vs NYA | 9 | W 4-1 | 4-5 | 6 | 18,704 | Chuck Estrada | Danny McDevitt | Chuck Estrada | Danny McDevitt | Dick Hall | 37 | 39 | -2 |
| 1961-04-24 | vs CLE | 10 | L 1-5 | 4-6 | 7 | 10,194 | Milt Pappas | Jim Perry | Jim Perry | Milt Pappas | Frank Funk | 38 | 44 | -6 |
| 1961-04-25 | vs CLE | 11 | W 5-2 | 5-6 | 6 | 8,474 | Steve Barber | Gary Bell | Steve Barber | Gary Bell | Hoyt Wilhelm | 43 | 46 | -3 |
| 1961-04-26 | vs CLE | 12 | L 3-6 | 5-7 | 7 | 12,383 | Jack Fisher | Mudcat Grant | Barry Latman | Jack Fisher | Bob Allen | 46 | 52 | -6 |
| 1961-04-27 | @ WS2 | 13 | W 5-0 | 6-7 | 7 | 4,541 | Dick Hall | Joe McClain | Dick Hall | Joe McClain | | 51 | 52 | -1 |
| 1961-04-28 | @ WS2 | 14 | W 4-2 | 7-7 | 7 | 4,112 | Chuck Estrada | Bennie Daniels | Hoyt Wilhelm | Bennie Daniels | | 55 | 54 | 1 |
| 1961-04-29 | @ WS2 | 15 | W 5-0 | 8-7 | 4 | 3,605 | Milt Pappas | Ed Hobaugh | Milt Pappas | Ed Hobaugh | | 60 | 54 | 6 |
| 1961-04-30 | @ DET | 16 | L 2-8 | 9-8 | 5 | 0 | Steve Barber | Don Mossi | Phil Regan | Steve Barber | Hank Aguirre | 62 | 62 | 0 |
| 1961-04-30 | @ DET | 17 | W 4-2 | 9-8 | 5 | 26,094 | Hal Brown | Paul Foytack | Hal Brown | Paul Foytack | | 66 | 64 | 2 |
| 1961-05-02 | @ LAA | 18 | W 7-6 | 10-8 | 4 | 6,664 | Dick Hall | Eli Grba | Hoyt Wilhelm | Tom Morgan | | 73 | 70 | 3 |
| 1961-05-03 | @ LAA | 19 | L 6-7 | 10-9 | 5 | 5,093 | Chuck Estrada | Ron Kline | Tex Clevenger | Hal Brown | | 79 | 77 | 2 |
| 1961-05-04 | @ LAA | 20 | W 8-7 | 11-9 | 4 | 4,886 | Milt Pappas | Ken McBride | Hoyt Wilhelm | Ned Garver | | 87 | 84 | 3 |
| 1961-05-06 | @ KC1 | 21 | W 6-0 | 12-9 | 3 | 7,650 | Steve Barber | Ken Johnson | Steve Barber | Ken Johnson | | 93 | 84 | 9 |
| 1961-05-07 | @ KC1 | 22 | L 4-5 | 12-10 | 3 | 10,123 | Jack Fisher | Jerry Walker | Bud Daley | Hoyt Wilhelm | | 97 | 89 | 8 |
| 1961-05-09 | @ MIN | 23 | W 13-5 | 13-10 | 3 | 4,514 | Chuck Estrada | Pedro Ramos | Chuck Estrada | Pedro Ramos | Gordon Jones | 110 | 94 | 16 |
| 1961-05-10 | @ MIN | 24 | L 6-10 | 13-11 | 3 | 5,410 | Dick Hall | Jack Kralick | Jack Kralick | Dick Hall | Ray Moore | 116 | 104 | 12 |
| 1961-05-11 | @ MIN | 25 | W 8-7 | 14-11 | 3 | 7,471 | Steve Barber | Camilo Pascual | Steve Barber | Camilo Pascual | Hoyt Wilhelm | 124 | 111 | 13 |
| 1961-05-12 | @ CLE | 26 | W 4-2 | 15-11 | 3 | 9,240 | Jack Fisher | Johnny Antonelli | Jack Fisher | Johnny Antonelli | | 128 | 113 | 15 |
| 1961-05-13 | @ CLE | 27 | W 4-1 | 16-11 | 2 | 3,417 | Hal Brown | Wynn Hawkins | Hal Brown | Wynn Hawkins | Hoyt Wilhelm | 132 | 114 | 18 |
| 1961-05-14 | @ CLE | 28 | L 0-1 | 16-13 | 4 | 0 | Billy Hoeft | Jim Perry | Frank Funk | Jack Fisher | | 132 | 115 | 17 |
| 1961-05-14 | @ CLE | 29 | L 4-6 | 16-13 | 4 | 13,238 | Chuck Estrada | Gary Bell | Barry Latman | Chuck Estrada | | 136 | 121 | 15 |
| 1961-05-15 | vs DET | 30 | L 5-10 | 16-14 | 5 | 15,783 | Dick Hall | Paul Foytack | Paul Foytack | Dick Hall | | 141 | 131 | 10 |
| 1961-05-16 | vs DET | 31 | L 4-10 | 16-15 | 5 | 12,813 | Steve Barber | Frank Lary | Frank Lary | Steve Barber | | 145 | 141 | 4 |
| 1961-05-17 | vs DET | 32 | L 1-9 | 16-16 | 5 | 11,701 | Jack Fisher | Phil Regan | Phil Regan | Jack Fisher | | 146 | 150 | -4 |
| 1961-05-19 | vs WS2 | 33 | W 4-2 | 17-16 | 5 | 7,269 | Billy Hoeft | Tom Sturdivant | Hoyt Wilhelm | Tom Sturdivant | | 150 | 152 | -2 |
| 1961-05-20 | vs WS2 | 34 | W 4-3 | 18-16 | 4 | 6,738 | Hal Brown | Joe McClain | Hal Brown | Joe McClain | Hoyt Wilhelm | 154 | 155 | -1 |
| 1961-05-21 | @ NYA | 35 | L 2-4 | 19-17 | 4 | 0 | Chuck Estrada | Whitey Ford | Whitey Ford | Chuck Estrada | | 156 | 159 | -3 |
| 1961-05-21 | @ NYA | 36 | W 3-2 | 19-17 | 4 | 47,890 | Steve Barber | Rollie Sheldon | Steve Barber | Rollie Sheldon | Hoyt Wilhelm | 159 | 161 | -2 |
| 1961-05-22 | @ NYA | 37 | L 2-8 | 19-18 | 5 | 16,923 | Jack Fisher | Art Ditmar | Jim Coates | Jack Fisher | Luis Arroyo | 161 | 169 | -8 |
| 1961-05-23 | vs CHA | 38 | W 3-1 | 20-18 | 4 | 17,945 | Billy Hoeft | Billy Pierce | Billy Hoeft | Billy Pierce | Hoyt Wilhelm | 164 | 170 | -6 |
| 1961-05-24 | vs CHA | 39 | W 2-1 | 22-18 | 3 | 0 | Hal Brown | Bob Shaw | Hal Brown | Bob Shaw | | 166 | 171 | -5 |
| 1961-05-24 | vs CHA | 40 | W 5-3 | 22-18 | 3 | 14,059 | Dick Hall | Russ Kemmerer | Wes Stock | Frank Baumann | | 171 | 174 | -3 |
| 1961-05-25 | vs CHA | 41 | W 6-4 | 23-18 | 3 | 8,856 | Steve Barber | Herb Score | Steve Barber | Herb Score | Hoyt Wilhelm | 177 | 178 | -1 |
| 1961-05-27 | vs BOS | 42 | W 5-4 | 24-18 | 3 | 6,777 | Chuck Estrada | Bill Monbouquette | Dick Hyde | Bill Monbouquette | | 182 | 182 | 0 |
| 1961-05-28 | vs BOS | 43 | L 0-5 | 24-19 | 3 | 11,519 | Jack Fisher | Don Schwall | Don Schwall | Jack Fisher | | 182 | 187 | -5 |
| 1961-05-30 | @ CHA | 44 | W 6-0 | 26-19 | 3 | 0 | Steve Barber | Bob Shaw | Steve Barber | Bob Shaw | | 188 | 187 | 1 |
| 1961-05-30 | @ CHA | 45 | W 2-1 | 26-19 | 3 | 28,550 | Hal Brown | Billy Pierce | Hal Brown | Billy Pierce | Hoyt Wilhelm | 190 | 188 | 2 |
| 1961-05-31 | @ CHA | 46 | L 4-9 | 26-20 | 3 | 11,447 | Chuck Estrada | Frank Baumann | Frank Baumann | Chuck Estrada | | 194 | 197 | -3 |
| 1961-06-02 | @ BOS | 47 | L 2-4 | 26-21 | 4 | 17,714 | Billy Hoeft | Don Schwall | Don Schwall | Billy Hoeft | | 196 | 201 | -5 |
| 1961-06-03 | @ BOS | 48 | W 3-1 | 27-21 | 3 | 9,156 | Jack Fisher | Ike Delock | Jack Fisher | Ike Delock | | 199 | 202 | -3 |
| 1961-06-04 | @ BOS | 49 | L 5-6 | 27-22 | 4 | 14,409 | Steve Barber | Gene Conley | Billy Muffett | Hoyt Wilhelm | | 204 | 208 | -4 |
| 1961-06-05 | vs LAA | 50 | L 0-3 | 27-23 | 4 | 6,931 | Hal Brown | Ron Moeller | Ron Moeller | Hal Brown | | 204 | 211 | -7 |
| 1961-06-06 | vs LAA | 51 | L 3-7 | 28-24 | 4 | 0 | Milt Pappas | Eli Grba | Eli Grba | Milt Pappas | Art Fowler | 207 | 218 | -11 |
| 1961-06-06 | vs LAA | 52 | W 2-0 | 28-24 | 4 | 14,320 | Chuck Estrada | Ken McBride | Chuck Estrada | Ken McBride | | 209 | 218 | -9 |
| 1961-06-07 | vs LAA | 53 | L 0-4 | 28-25 | 4 | 7,575 | Billy Hoeft | Ted Bowsfield | Ted Bowsfield | Billy Hoeft | | 209 | 222 | -13 |
| 1961-06-08 | vs MIN | 54 | L 1-3 | 28-26 | 4 | 6,751 | Jack Fisher | Jim Kaat | Jim Kaat | Jack Fisher | Chuck Stobbs | 210 | 225 | -15 |
| 1961-06-10 | vs MIN | 55 | W 4-3 | 29-26 | 4 | 8,183 | Hal Brown | Camilo Pascual | Hal Brown | Camilo Pascual | Hoyt Wilhelm | 214 | 228 | -14 |
| 1961-06-11 | vs CHA | 56 | W 8-2 | 30-27 | 4 | 0 | Chuck Estrada | Frank Baumann | Chuck Estrada | Frank Baumann | | 222 | 230 | -8 |
| 1961-06-11 | vs CHA | 57 | L 1-7 | 30-27 | 4 | 19,096 | Steve Barber | Billy Pierce | Billy Pierce | Steve Barber | | 223 | 237 | -14 |
| 1961-06-12 | vs CHA | 58 | L 8-9 | 30-28 | 4 | 12,295 | Billy Hoeft | Russ Kemmerer | Don Larsen | Dick Hyde | Turk Lown | 231 | 246 | -15 |
| 1961-06-13 | vs WS2 | 59 | W 8-7 | 31-28 | 4 | 7,205 | Jack Fisher | Pete Burnside | Dick Hall | Tom Sturdivant | | 239 | 253 | -14 |
| 1961-06-14 | vs WS2 | 60 | L 1-5 | 31-29 | 4 | 8,363 | Steve Barber | Dick Donovan | Dick Donovan | Steve Barber | | 240 | 258 | -18 |
| 1961-06-15 | vs WS2 | 61 | L 2-5 | 31-30 | 4 | 7,651 | Hal Brown | Ed Hobaugh | Ed Hobaugh | Hal Brown | | 242 | 263 | -21 |
| 1961-06-16 | @ CLE | 62 | L 1-3 | 31-31 | 4 | 12,254 | Chuck Estrada | Dick Stigman | Dick Stigman | Chuck Estrada | Barry Latman | 243 | 266 | -23 |
| 1961-06-17 | @ CLE | 63 | W 4-1 | 32-31 | 4 | 5,901 | Milt Pappas | Wynn Hawkins | Milt Pappas | Wynn Hawkins | Hoyt Wilhelm | 247 | 267 | -20 |
| 1961-06-18 | @ CLE | 64 | L 1-2 | 33-32 | 5 | 0 | Steve Barber | Jim Perry | Jim Perry | Steve Barber | | 248 | 269 | -21 |
| 1961-06-18 | @ CLE | 65 | W 8-5 | 33-32 | 5 | 24,821 | Jack Fisher | Gary Bell | Wes Stock | Gary Bell | Dick Hall | 256 | 274 | -18 |
| 1961-06-20 | @ MIN | 66 | L 4-5 | 33-33 | 5 | 17,851 | Hal Brown | Jack Kralick | Chuck Stobbs | Jack Fisher | | 260 | 279 | -19 |
| 1961-06-21 | @ MIN | 67 | W 11-5 | 34-33 | 5 | 15,711 | Chuck Estrada | Pedro Ramos | Hoyt Wilhelm | Bert Cueto | | 271 | 284 | -13 |
| 1961-06-22 | @ MIN | 68 | W 8-2 | 35-33 | 5 | 10,397 | Milt Pappas | Jim Kaat | Milt Pappas | Jim Kaat | | 279 | 286 | -7 |
| 1961-06-23 | @ LAA | 69 | W 8-6 | 36-33 | 5 | 6,554 | Steve Barber | Ted Bowsfield | Steve Barber | Ron Kline | Hoyt Wilhelm | 287 | 292 | -5 |
| 1961-06-24 | @ LAA | 70 | L 1-4 | 36-34 | 5 | 7,882 | Dick Hall | Ron Moeller | Ron Moeller | Dick Hall | Art Fowler | 288 | 296 | -8 |
| 1961-06-25 | @ LAA | 71 | W 9-8 | 37-34 | 4 | 6,526 | Hal Brown | Eli Grba | Dick Hall | Ron Kline | Jack Fisher | 297 | 304 | -7 |
| 1961-06-27 | @ KC1 | 72 | W 5-3 | 39-34 | 4 | 0 | Milt Pappas | Norm Bass | Milt Pappas | Ed Rakow | Hoyt Wilhelm | 302 | 307 | -5 |
| 1961-06-27 | @ KC1 | 73 | W 7-2 | 39-34 | 4 | 10,448 | Chuck Estrada | Art Ditmar | Chuck Estrada | Art Ditmar | Billy Hoeft | 309 | 309 | 0 |
| 1961-06-28 | @ KC1 | 74 | W 5-4 | 40-34 | 4 | 6,000 | Steve Barber | Jim Archer | Wes Stock | Jim Archer | | 314 | 313 | 1 |
| 1961-06-29 | @ KC1 | 75 | W 6-2 | 41-34 | 4 | 10,415 | Dick Hall | Lew Krausse | Dick Hall | Lew Krausse | | 320 | 315 | 5 |
| 1961-06-30 | vs DET | 76 | L 5-6 | 41-35 | 4 | 33,710 | Jack Fisher | Jim Bunning | Terry Fox | Hoyt Wilhelm | | 325 | 321 | 4 |
| 1961-07-01 | vs DET | 77 | L 8-11 | 41-36 | 4 | 10,884 | Hal Brown | Bob Bruce | Bill Fischer | Dick Hyde | | 333 | 332 | 1 |
| 1961-07-02 | vs DET | 78 | W 6-3 | 42-36 | 4 | 11,115 | Chuck Estrada | Phil Regan | Chuck Estrada | Phil Regan | Billy Hoeft | 339 | 335 | 4 |
| 1961-07-03 | vs CLE | 79 | W 5-0 | 43-36 | 4 | 17,152 | Milt Pappas | Jim Perry | Milt Pappas | Jim Perry | | 344 | 335 | 9 |
| 1961-07-04 | vs CLE | 80 | W 5-1 | 44-36 | 4 | 38,206 | Steve Barber | Wynn Hawkins | Steve Barber | Wynn Hawkins | | 349 | 336 | 13 |
| 1961-07-05 | @ WS2 | 81 | W 2-0 | 45-36 | 3 | 6,625 | Dick Hall | Bennie Daniels | Dick Hall | Bennie Daniels | | 351 | 336 | 15 |
| 1961-07-06 | @ WS2 | 82 | L 0-1 | 45-37 | 3 | 5,483 | Wes Stock | Dick Donovan | Dick Donovan | Hoyt Wilhelm | | 351 | 337 | 14 |
| 1961-07-07 | vs KC1 | 83 | W 6-2 | 47-37 | 3 | 0 | Chuck Estrada | Ed Rakow | Chuck Estrada | Ed Rakow | | 357 | 339 | 18 |
| 1961-07-07 | vs KC1 | 84 | W 5-0 | 47-37 | 3 | 20,152 | Hal Brown | Jim Archer | Hal Brown | Jim Archer | | 362 | 339 | 23 |
| 1961-07-08 | vs KC1 | 85 | W 7-2 | 48-37 | 3 | 14,046 | Milt Pappas | Lew Krausse | Milt Pappas | Lew Krausse | | 369 | 341 | 28 |
| 1961-07-09 | vs KC1 | 86 | W 8-0 | 49-37 | 3 | 7,849 | Steve Barber | Bob Shaw | Steve Barber | Bob Shaw | | 377 | 341 | 36 |
| 1961-07-13 | @ BOS | 87 | L 2-3 | 49-38 | 3 | 18,012 | Milt Pappas | Don Schwall | Don Schwall | Milt Pappas | Mike Fornieles | 379 | 344 | 35 |
| 1961-07-14 | @ BOS | 88 | W 7-6 | 50-38 | 3 | 11,325 | Chuck Estrada | Bill Monbouquette | Wes Stock | Mike Fornieles | | 386 | 350 | 36 |
| 1961-07-15 | @ BOS | 89 | L 1-2 | 50-39 | 3 | 7,527 | Dick Hall | Gene Conley | Gene Conley | Dick Hall | | 387 | 352 | 35 |
| 1961-07-16 | vs NYA | 90 | L 1-2 | 50-40 | 3 | 38,487 | Steve Barber | Bud Daley | Bud Daley | Steve Barber | | 388 | 354 | 34 |
| 1961-07-17 | vs NYA | 91 | L 0-5 | 50-41 | 3 | 44,332 | Milt Pappas | Whitey Ford | Whitey Ford | Milt Pappas | | 388 | 359 | 29 |
| 1961-07-18 | @ DET | 92 | W 8-7 | 51-41 | 3 | 31,018 | Chuck Estrada | Frank Lary | Hoyt Wilhelm | Bill Fischer | | 396 | 366 | 30 |
| 1961-07-19 | @ DET | 93 | W 4-2 | 52-41 | 3 | 29,475 | Jack Fisher | Jim Bunning | Jack Fisher | Jim Bunning | Hal Brown | 400 | 368 | 32 |
| 1961-07-20 | @ DET | 94 | L 8-15 | 52-42 | 3 | 18,269 | Steve Barber | Don Mossi | Hal Woodeshick | Steve Barber | Hank Aguirre | 408 | 383 | 25 |
| 1961-07-22 | @ CHA | 95 | L 4-7 | 52-44 | 4 | 10,946 | Dick Hall | Early Wynn | Turk Lown | Hoyt Wilhelm | | 412 | 390 | 22 |
| 1961-07-22 | @ CHA | 96 | L 4-11 | 52-44 | 4 | 20,156 | Milt Pappas | Billy Pierce | Billy Pierce | Milt Pappas | Warren Hacker | 416 | 401 | 15 |
| 1961-07-23 | @ CHA | 97 | L 2-5 | 52-45 | 4 | 13,620 | Chuck Estrada | Cal McLish | Cal McLish | Jack Fisher | Turk Lown | 418 | 406 | 12 |
| 1961-07-25 | vs BOS | 98 | W 5-1 | 53-45 | 3 | 8,673 | Steve Barber | Ike Delock | Steve Barber | Ike Delock | | 423 | 407 | 16 |
| 1961-07-26 | vs BOS | 99 | W 5-1 | 55-45 | 3 | 0 | Billy Hoeft | Bill Monbouquette | Wes Stock | Bill Monbouquette | Hoyt Wilhelm | 428 | 408 | 20 |
| 1961-07-26 | vs BOS | 100 | W 9-2 | 55-45 | 3 | 14,950 | Jack Fisher | Gene Conley | Jack Fisher | Gene Conley | | 437 | 410 | 27 |
| 1961-07-27 | vs BOS | 101 | W 8-5 | 56-45 | 3 | 9,905 | Chuck Estrada | Tracy Stallard | Chuck Estrada | Billy Muffett | | 445 | 415 | 30 |
| 1961-07-28 | @ NYA | 102 | W 4-0 | 57-45 | 3 | 39,623 | Hal Brown | Bud Daley | Hal Brown | Bud Daley | | 449 | 415 | 34 |
| 1961-07-29 | @ NYA | 103 | L 4-5 | 57-46 | 3 | 42,990 | Hoyt Wilhelm | Whitey Ford | Whitey Ford | Jack Fisher | | 453 | 420 | 33 |
| 1961-07-30 | @ NYA | 104 | W 4-0 | 59-46 | 3 | 0 | Steve Barber | Bill Stafford | Steve Barber | Bill Stafford | | 457 | 420 | 37 |
| 1961-07-30 | @ NYA | 105 | W 2-1 | 59-46 | 3 | 57,180 | Milt Pappas | Rollie Sheldon | Milt Pappas | Bud Daley | Dick Hall | 459 | 421 | 38 |
| 1961-08-02 | vs MIN | 106 | L 3-4 | 60-47 | 3 | 0 | Chuck Estrada | Don Lee | Bill Pleis | Chuck Estrada | Ray Moore | 462 | 425 | 37 |
| 1961-08-02 | vs MIN | 107 | W 4-3 | 60-47 | 3 | 14,379 | Dick Hall | Pedro Ramos | Hoyt Wilhelm | Pedro Ramos | | 466 | 428 | 38 |
| 1961-08-03 | vs MIN | 108 | W 3-0 | 61-47 | 3 | 8,806 | Hal Brown | Jim Kaat | Hal Brown | Jim Kaat | | 469 | 428 | 41 |
| 1961-08-04 | vs LAA | 109 | L 1-3 | 62-48 | 3 | 0 | Steve Barber | Ted Bowsfield | Ted Bowsfield | Steve Barber | | 470 | 431 | 39 |
| 1961-08-04 | vs LAA | 110 | W 3-0 | 62-48 | 3 | 10,972 | Jack Fisher | Eli Grba | Jack Fisher | Eli Grba | | 473 | 431 | 42 |
| 1961-08-05 | vs LAA | 111 | L 2-4 | 62-49 | 3 | 10,642 | Milt Pappas | Ron Kline | Ron Kline | Hoyt Wilhelm | Tom Morgan | 475 | 435 | 40 |
| 1961-08-07 | vs KC1 | 112 | W 5-4 | 63-49 | 3 | 7,106 | Chuck Estrada | Art Ditmar | Chuck Estrada | Art Ditmar | Billy Hoeft | 480 | 439 | 41 |
| 1961-08-08 | vs KC1 | 113 | W 7-0 | 64-50 | 3 | 0 | Steve Barber | Bob Shaw | Steve Barber | Bob Shaw | | 487 | 439 | 48 |
| 1961-08-08 | vs KC1 | 114 | L 5-6 | 64-50 | 3 | 14,102 | Hal Brown | Norm Bass | Norm Bass | Hoyt Wilhelm | Bill Fischer | 492 | 445 | 47 |
| 1961-08-09 | vs KC1 | 115 | L 1-2 | 64-51 | 3 | 7,419 | Jack Fisher | Jerry Walker | Jerry Walker | Jack Fisher | | 493 | 447 | 46 |
| 1961-08-10 | vs KC1 | 116 | W 8-0 | 65-51 | 3 | 6,027 | Milt Pappas | Bill Kunkel | Milt Pappas | Bill Kunkel | | 501 | 447 | 54 |
| 1961-08-11 | vs BOS | 117 | W 6-3 | 66-51 | 3 | 24,076 | Billy Hoeft | Chet Nichols | Billy Hoeft | Chet Nichols | Wes Stock | 507 | 450 | 57 |
| 1961-08-12 | vs BOS | 118 | W 8-3 | 67-51 | 3 | 14,686 | Dick Hall | Ike Delock | Dick Hall | Ike Delock | Wes Stock | 515 | 453 | 62 |
| 1961-08-13 | vs BOS | 119 | W 6-5 | 68-51 | 3 | 10,518 | Steve Barber | Bill Monbouquette | Steve Barber | Mike Fornieles | | 521 | 458 | 63 |
| 1961-08-15 | @ DET | 120 | L 0-2 | 68-53 | 3 | 0 | Chuck Estrada | Frank Lary | Frank Lary | Chuck Estrada | | 521 | 460 | 61 |
| 1961-08-15 | @ DET | 121 | L 2-3 | 68-53 | 3 | 49,558 | Hal Brown | Don Mossi | Gerry Staley | Hal Brown | | 523 | 463 | 60 |
| 1961-08-16 | @ DET | 122 | W 8-2 | 69-53 | 3 | 19,754 | Milt Pappas | Jim Bunning | Milt Pappas | Jim Bunning | | 531 | 465 | 66 |
| 1961-08-17 | @ DET | 123 | W 3-1 | 70-53 | 3 | 24,241 | Jack Fisher | Paul Foytack | Jack Fisher | Paul Foytack | | 534 | 466 | 68 |
| 1961-08-18 | @ WS2 | 124 | W 3-2 | 71-53 | 3 | 11,624 | Steve Barber | Joe McClain | Steve Barber | Joe McClain | | 537 | 468 | 69 |
| 1961-08-19 | @ WS2 | 125 | W 5-0 | 72-53 | 3 | 5,874 | Billy Hoeft | Marty Kutyna | Billy Hoeft | Marty Kutyna | | 542 | 468 | 74 |
| 1961-08-20 | @ WS2 | 126 | W 9-3 | 73-53 | 3 | 7,221 | Chuck Estrada | Dick Donovan | Chuck Estrada | Dick Donovan | | 551 | 471 | 80 |
| 1961-08-22 | @ KC1 | 127 | L 2-3 | 73-54 | 3 | 4,978 | Milt Pappas | Norm Bass | Bill Fischer | Milt Pappas | | 553 | 474 | 79 |
| 1961-08-23 | @ KC1 | 128 | W 7-5 | 74-54 | 3 | 5,429 | Hal Brown | Bob Shaw | Billy Hoeft | Bill Kunkel | | 560 | 479 | 81 |
| 1961-08-24 | @ KC1 | 129 | L 3-5 | 74-55 | 3 | 7,695 | Steve Barber | Ed Rakow | Bill Kunkel | Dick Hall | | 563 | 484 | 79 |
| 1961-08-25 | @ MIN | 130 | W 5-2 | 75-55 | 3 | 24,974 | Jack Fisher | Jack Kralick | Jack Fisher | Jack Kralick | | 568 | 486 | 82 |
| 1961-08-26 | @ MIN | 131 | W 7-4 | 76-55 | 3 | 19,397 | Chuck Estrada | Al Schroll | Chuck Estrada | Al Schroll | Wes Stock | 575 | 490 | 85 |
| 1961-08-27 | @ MIN | 132 | W 3-0 | 77-55 | 3 | 19,406 | Milt Pappas | Pedro Ramos | Milt Pappas | Pedro Ramos | | 578 | 490 | 88 |
| 1961-08-28 | @ LAA | 133 | W 8-1 | 78-55 | 3 | 3,472 | Hal Brown | Ted Bowsfield | Hal Brown | Ted Bowsfield | | 586 | 491 | 95 |
| 1961-08-29 | @ LAA | 134 | L 5-6 | 78-57 | 3 | 0 | Steve Barber | Ryne Duren | Ryne Duren | Steve Barber | Tom Morgan | 591 | 497 | 94 |
| 1961-08-29 | @ LAA | 135 | L 5-6 | 78-57 | 3 | 6,522 | Billy Hoeft | Jack Spring | Eli Grba | Billy Hoeft | | 596 | 503 | 93 |
| 1961-08-30 | @ LAA | 136 | W 11-4 | 79-57 | 3 | 5,253 | Jack Fisher | Ron Moeller | Jack Fisher | Ron Moeller | | 607 | 507 | 100 |
| 1961-09-01 | vs CLE | 137 | L 4-5 | 79-58 | 3 | 12,721 | Chuck Estrada | Barry Latman | Barry Latman | Chuck Estrada | Frank Funk | 611 | 512 | 99 |
| 1961-09-02 | vs CLE | 138 | W 3-2 | 80-59 | 3 | 6,890 | Milt Pappas | Dick Stigman | Milt Pappas | Bobby Locke | Hoyt Wilhelm | 614 | 514 | 100 |
| 1961-09-02 | vs CLE | 139 | L 0-6 | 80-59 | 3 | 7,896 | Hal Brown | Jim Perry | Jim Perry | Hal Brown | | 614 | 520 | 94 |
| 1961-09-03 | vs CLE | 140 | W 1-0 | 81-59 | 3 | 8,100 | Steve Barber | Gary Bell | Steve Barber | Bob Allen | | 615 | 520 | 95 |
| 1961-09-04 | vs DET | 141 | W 6-3 | 83-59 | 3 | 0 | Jack Fisher | Paul Foytack | Jack Fisher | Paul Foytack | Hoyt Wilhelm | 621 | 523 | 98 |
| 1961-09-04 | vs DET | 142 | W 4-1 | 83-59 | 3 | 19,334 | Billy Hoeft | Ron Kline | Billy Hoeft | Ron Kline | Hoyt Wilhelm | 625 | 524 | 101 |
| 1961-09-05 | vs DET | 143 | W 1-0 | 84-59 | 3 | 13,841 | Chuck Estrada | Don Mossi | Chuck Estrada | Don Mossi | Steve Barber | 626 | 524 | 102 |
| 1961-09-07 | vs WS2 | 144 | W 6-3 | 85-59 | 3 | 2,836 | Milt Pappas | Carl Bouldin | Milt Pappas | Carl Bouldin | | 632 | 527 | 105 |
| 1961-09-08 | vs WS2 | 145 | W 2-1 | 87-59 | 3 | 0 | Steve Barber | Pete Burnside | Hoyt Wilhelm | Pete Burnside | | 634 | 528 | 106 |
| 1961-09-08 | vs WS2 | 146 | W 4-2 | 87-59 | 3 | 10,520 | Dick Hall | Ed Hobaugh | Dick Hall | Ed Hobaugh | | 638 | 530 | 108 |
| 1961-09-09 | vs WS2 | 147 | L 2-6 | 87-60 | 3 | 7,891 | Jack Fisher | Bennie Daniels | Bennie Daniels | Jack Fisher | | 640 | 536 | 104 |
| 1961-09-10 | vs WS2 | 148 | W 3-2 | 88-60 | 3 | 6,729 | Chuck Estrada | Joe McClain | Chuck Estrada | Joe McClain | Hoyt Wilhelm | 643 | 538 | 105 |
| 1961-09-13 | @ CLE | 149 | L 0-5 | 88-61 | 3 | 4,221 | Steve Barber | Gary Bell | Gary Bell | Steve Barber | | 643 | 543 | 100 |
| 1961-09-15 | @ BOS | 150 | L 2-3 | 88-62 | 3 | 10,604 | Milt Pappas | Gene Conley | Gene Conley | Milt Pappas | | 645 | 546 | 99 |
| 1961-09-16 | @ BOS | 151 | W 5-4 | 89-62 | 3 | 7,089 | Jack Fisher | Don Schwall | Billy Hoeft | Don Schwall | | 650 | 550 | 100 |
| 1961-09-17 | @ BOS | 152 | L 0-1 | 89-63 | 3 | 9,203 | Chuck Estrada | Bill Monbouquette | Bill Monbouquette | Chuck Estrada | | 650 | 551 | 99 |
| 1961-09-19 | vs NYA | 153 | W 1-0 | 90-64 | 3 | 0 | Steve Barber | Whitey Ford | Steve Barber | Whitey Ford | | 651 | 551 | 100 |
| 1961-09-19 | vs NYA | 154 | L 1-3 | 90-64 | 3 | 31,317 | Hal Brown | Bud Daley | Bud Daley | Hal Brown | | 652 | 554 | 98 |
| 1961-09-20 | vs NYA | 155 | L 2-4 | 90-65 | 3 | 21,032 | Milt Pappas | Ralph Terry | Ralph Terry | Milt Pappas | | 654 | 558 | 96 |
| 1961-09-21 | vs NYA | 156 | W 5-3 | 91-65 | 3 | 22,089 | Jack Fisher | Bill Stafford | Jack Fisher | Bill Stafford | | 659 | 561 | 98 |
| 1961-09-22 | @ CHA | 157 | W 8-6 | 92-65 | 3 | 12,276 | Chuck Estrada | Frank Baumann | Chuck Estrada | Frank Baumann | Milt Pappas | 667 | 567 | 100 |
| 1961-09-24 | @ CHA | 158 | L 7-8 | 93-66 | 3 | 0 | Steve Barber | Joe Horlen | Billy Pierce | Steve Barber | Warren Hacker | 674 | 575 | 99 |
| 1961-09-24 | @ CHA | 159 | W 5-3 | 93-66 | 3 | 7,320 | Billy Hoeft | Juan Pizarro | Billy Hoeft | Juan Pizarro | Hoyt Wilhelm | 679 | 578 | 101 |
| 1961-09-26 | @ NYA | 160 | L 2-3 | 93-67 | 3 | 19,401 | Jack Fisher | Bud Daley | Rollie Sheldon | Jack Fisher | | 681 | 581 | 100 |
| 1961-09-27 | @ NYA | 161 | W 3-2 | 94-67 | 3 | 7,594 | Steve Barber | Bill Stafford | Steve Barber | Bill Stafford | Dick Hall | 684 | 583 | 101 |
| 1961-09-29 | vs CHA | 162 | W 3-2 | 95-67 | 3 | 16,061 | Chuck Estrada | Juan Pizarro | Chuck Estrada | Warren Hacker | | 687 | 585 | 102 |
| 1961-09-30 | vs CHA | 163 | W 4-3 | 96-67 | 3 | 6,515 | Hal Brown | Herb Score | Milt Pappas | Don Larsen | | 691 | 588 | 103 |