| 1959-04-10 | @ SLN | 1 | W 6-5 | 1-0 | 2 | 20,988 | Johnny Antonelli | Larry Jackson | Johnny Antonelli | Jim Brosnan | Al Worthington | 6 | 5 | 1 |
| 1959-04-11 | @ SLN | 2 | W 5-2 | 2-0 | 3 | 8,518 | Sam Jones | Ernie Broglio | Sam Jones | Ernie Broglio | | 11 | 7 | 4 |
| 1959-04-12 | @ SLN | 3 | W 6-3 | 3-0 | 2 | 12,177 | Mike McCormick | Vinegar Bend Mizell | Al Worthington | Vinegar Bend Mizell | | 17 | 10 | 7 |
| 1959-04-14 | vs CHN | 4 | L 2-5 | 3-1 | 2 | 22,522 | Jack Sanford | Dave Hillman | Dave Hillman | Jack Sanford | Don Elston | 19 | 15 | 4 |
| 1959-04-15 | vs CHN | 5 | W 7-1 | 4-1 | 2 | 15,479 | Johnny Antonelli | Moe Drabowsky | Johnny Antonelli | Moe Drabowsky | | 26 | 16 | 10 |
| 1959-04-16 | vs CHN | 6 | L 3-11 | 4-2 | 3 | 11,056 | Sam Jones | Glen Hobbie | Glen Hobbie | Sam Jones | Don Elston | 29 | 27 | 2 |
| 1959-04-17 | vs SLN | 7 | L 1-4 | 4-3 | 4 | 19,945 | Mike McCormick | Vinegar Bend Mizell | Vinegar Bend Mizell | Mike McCormick | | 30 | 31 | -1 |
| 1959-04-18 | vs SLN | 8 | W 8-1 | 5-3 | 2 | 19,393 | Jack Sanford | Lindy McDaniel | Jack Sanford | Lindy McDaniel | | 38 | 32 | 6 |
| 1959-04-19 | vs SLN | 9 | W 3-1 | 6-3 | 2 | 22,785 | Johnny Antonelli | Larry Jackson | Johnny Antonelli | Larry Jackson | | 41 | 33 | 8 |
| 1959-04-20 | @ LAN | 10 | L 1-2 | 6-4 | 3 | 32,946 | Sam Jones | Don Drysdale | Don Drysdale | Sam Jones | | 42 | 35 | 7 |
| 1959-04-21 | @ LAN | 11 | L 7-9 | 6-5 | 4 | 30,423 | Stu Miller | Stan Williams | Art Fowler | Al Worthington | | 49 | 44 | 5 |
| 1959-04-22 | @ LAN | 12 | W 6-3 | 7-5 | 3 | 38,036 | Jack Sanford | Carl Erskine | Jack Sanford | Carl Erskine | Sam Jones | 55 | 47 | 8 |
| 1959-04-24 | @ CHN | 13 | W 4-3 | 8-5 | 3 | 3,511 | Johnny Antonelli | Dave Hillman | Stu Miller | John Buzhardt | | 59 | 50 | 9 |
| 1959-04-25 | @ CHN | 14 | L 3-5 | 8-6 | 3 | 13,873 | Sam Jones | Bob Anderson | Bob Anderson | Sam Jones | Don Elston | 62 | 55 | 7 |
| 1959-04-26 | @ CHN | 15 | W 3-2 | 9-6 | 3 | 8,427 | Jack Sanford | Glen Hobbie | Jack Sanford | Glen Hobbie | | 65 | 57 | 8 |
| 1959-04-29 | @ PIT | 16 | L 2-3 | 9-7 | 4 | 19,799 | Johnny Antonelli | Ron Kline | Ron Kline | Johnny Antonelli | | 67 | 60 | 7 |
| 1959-05-01 | @ MLN | 17 | W 6-4 | 10-7 | 3 | 16,900 | Sam Jones | Carl Willey | Sam Jones | Carl Willey | Stu Miller | 73 | 64 | 9 |
| 1959-05-02 | @ MLN | 18 | W 8-5 | 11-7 | 2 | 20,127 | Jack Sanford | Joey Jay | Jack Sanford | Joey Jay | Gordon Jones | 81 | 69 | 12 |
| 1959-05-03 | @ MLN | 19 | L 4-9 | 11-8 | 3 | 22,911 | Johnny Antonelli | Lew Burdette | Lew Burdette | Johnny Antonelli | | 85 | 78 | 7 |
| 1959-05-04 | @ CIN | 20 | W 6-5 | 12-8 | 2 | 5,932 | Mike McCormick | Bob Purkey | Gordon Jones | Bob Purkey | Jack Sanford | 91 | 83 | 8 |
| 1959-05-05 | @ CIN | 21 | L 2-5 | 12-9 | 3 | 13,822 | Sam Jones | Don Newcombe | Don Newcombe | Sam Jones | | 93 | 88 | 5 |
| 1959-05-07 | vs LAN | 22 | L 1-2 | 12-10 | 4 | 14,216 | Jack Sanford | Stan Williams | Stan Williams | Jack Sanford | | 94 | 90 | 4 |
| 1959-05-08 | vs LAN | 23 | W 9-3 | 13-10 | 3 | 22,706 | Johnny Antonelli | Danny McDevitt | Johnny Antonelli | Danny McDevitt | | 103 | 93 | 10 |
| 1959-05-09 | vs LAN | 24 | L 5-6 | 13-11 | 4 | 22,679 | Sam Jones | Don Drysdale | Clem Labine | Gordon Jones | | 108 | 99 | 9 |
| 1959-05-10 | vs LAN | 25 | L 2-3 | 13-12 | 4 | 22,641 | Mike McCormick | Johnny Podres | Johnny Podres | Mike McCormick | Clem Labine | 110 | 102 | 8 |
| 1959-05-11 | vs PIT | 26 | W 14-4 | 14-12 | 4 | 13,789 | Jack Sanford | Bennie Daniels | Jack Sanford | Bennie Daniels | | 124 | 106 | 18 |
| 1959-05-12 | vs PIT | 27 | L 5-6 | 14-13 | 4 | 8,084 | Johnny Antonelli | Vern Law | Bennie Daniels | Gordon Jones | | 129 | 112 | 17 |
| 1959-05-13 | vs PHI | 28 | W 6-0 | 15-13 | 3 | 5,128 | Sam Jones | Ruben Gomez | Sam Jones | Ruben Gomez | | 135 | 112 | 23 |
| 1959-05-14 | vs PHI | 29 | W 8-0 | 16-13 | 3 | 6,235 | Mike McCormick | Ray Semproch | Mike McCormick | Ray Semproch | | 143 | 112 | 31 |
| 1959-05-15 | vs CIN | 30 | L 2-5 | 16-14 | 4 | 21,614 | Jack Sanford | Don Newcombe | Don Newcombe | Jack Sanford | | 145 | 117 | 28 |
| 1959-05-16 | vs CIN | 31 | W 9-2 | 17-14 | 2 | 18,911 | Johnny Antonelli | Brooks Lawrence | Johnny Antonelli | Brooks Lawrence | | 154 | 119 | 35 |
| 1959-05-17 | vs CIN | 32 | W 9-1 | 18-14 | 2 | 22,725 | Stu Miller | Bob Purkey | Stu Miller | Bob Purkey | | 163 | 120 | 43 |
| 1959-05-18 | vs MLN | 33 | L 2-4 | 18-15 | 2 | 17,524 | Sam Jones | Warren Spahn | Warren Spahn | Sam Jones | | 165 | 124 | 41 |
| 1959-05-19 | vs MLN | 34 | L 1-8 | 18-16 | 3 | 22,910 | Jack Sanford | Joey Jay | Joey Jay | Jack Sanford | | 166 | 132 | 34 |
| 1959-05-20 | vs MLN | 35 | W 6-3 | 19-16 | 3 | 17,825 | Mike McCormick | Bob Buhl | Mike McCormick | Bob Buhl | Sam Jones | 172 | 135 | 37 |
| 1959-05-22 | @ LAN | 36 | L 1-2 | 19-17 | 3 | 31,014 | Johnny Antonelli | Don Drysdale | Don Drysdale | Al Worthington | | 173 | 137 | 36 |
| 1959-05-23 | @ LAN | 37 | W 4-2 | 20-17 | 2 | 37,258 | Sam Jones | Stan Williams | Sam Jones | Stan Williams | | 177 | 139 | 38 |
| 1959-05-24 | @ LAN | 38 | W 6-1 | 21-17 | 2 | 30,518 | Jack Sanford | Danny McDevitt | Jack Sanford | Danny McDevitt | | 183 | 140 | 43 |
| 1959-05-25 | vs LAN | 39 | L 0-8 | 21-18 | 2 | 9,173 | Mike McCormick | Johnny Podres | Johnny Podres | Mike McCormick | | 183 | 148 | 35 |
| 1959-05-26 | vs LAN | 40 | W 6-4 | 22-18 | 2 | 18,471 | Stu Miller | Sandy Koufax | Gordon Jones | Sandy Koufax | | 189 | 152 | 37 |
| 1959-05-27 | vs SLN | 41 | W 9-4 | 23-18 | 2 | 8,017 | Johnny Antonelli | Gary Blaylock | Johnny Antonelli | Gary Blaylock | Al Worthington | 198 | 156 | 42 |
| 1959-05-28 | vs SLN | 42 | W 5-4 | 24-18 | 2 | 7,814 | Sam Jones | Larry Jackson | Stu Miller | Lindy McDaniel | Mike McCormick | 203 | 160 | 43 |
| 1959-05-29 | vs SLN | 43 | L 2-4 | 24-19 | 2 | 20,199 | Jack Sanford | Vinegar Bend Mizell | Vinegar Bend Mizell | Jack Sanford | Lindy McDaniel | 205 | 164 | 41 |
| 1959-05-30 | vs CHN | 44 | W 5-2 | 25-19 | 2 | 21,890 | Mike McCormick | Bob Anderson | Mike McCormick | Bob Anderson | | 210 | 166 | 44 |
| 1959-05-31 | vs CHN | 45 | W 6-3 | 26-19 | 2 | 21,828 | Johnny Antonelli | Glen Hobbie | Johnny Antonelli | Glen Hobbie | Stu Miller | 216 | 169 | 47 |
| 1959-06-01 | @ MLN | 46 | W 11-2 | 27-19 | 2 | 16,666 | Sam Jones | Joey Jay | Sam Jones | Joey Jay | | 227 | 171 | 56 |
| 1959-06-02 | @ MLN | 47 | L 0-3 | 27-20 | 2 | 20,364 | Stu Miller | Bob Rush | Bob Rush | Stu Miller | | 227 | 174 | 53 |
| 1959-06-03 | @ MLN | 48 | L 4-7 | 27-21 | 2 | 23,071 | Jack Sanford | Bob Buhl | Bob Buhl | Jack Sanford | Don McMahon | 231 | 181 | 50 |
| 1959-06-04 | @ MLN | 49 | W 11-5 | 28-21 | 2 | 16,713 | Mike McCormick | Lew Burdette | Gordon Jones | Lew Burdette | Stu Miller | 242 | 186 | 56 |
| 1959-06-05 | @ CIN | 50 | L 2-7 | 28-22 | 2 | 18,930 | Johnny Antonelli | Don Newcombe | Don Newcombe | Johnny Antonelli | | 244 | 193 | 51 |
| 1959-06-06 | @ CIN | 51 | W 13-3 | 29-22 | 2 | 9,956 | Sam Jones | Bob Purkey | Sam Jones | Bob Purkey | | 257 | 196 | 61 |
| 1959-06-07 | @ CIN | 52 | W 5-3 | 30-23 | 2 | 0 | Jack Sanford | Brooks Lawrence | Jack Sanford | Brooks Lawrence | | 262 | 199 | 63 |
| 1959-06-07 | @ CIN | 53 | L 1-7 | 30-23 | 2 | 25,557 | Mike McCormick | Orlando Pena | Orlando Pena | Mike McCormick | | 263 | 206 | 57 |
| 1959-06-08 | @ PIT | 54 | L 9-12 | 30-24 | 2 | 19,080 | Stu Miller | Ron Kline | Roy Face | Mike McCormick | | 272 | 218 | 54 |
| 1959-06-09 | @ PIT | 55 | W 6-2 | 31-24 | 2 | 24,272 | Johnny Antonelli | Vern Law | Johnny Antonelli | Vern Law | | 278 | 220 | 58 |
| 1959-06-10 | @ PIT | 56 | W 11-7 | 32-24 | 2 | 24,317 | Sam Jones | Red Witt | Sam Jones | Red Witt | Stu Miller | 289 | 227 | 62 |
| 1959-06-11 | @ PIT | 57 | L 9-12 | 32-25 | 2 | 9,444 | Jack Sanford | Bob Friend | Roy Face | Stu Miller | Vern Law | 298 | 239 | 59 |
| 1959-06-12 | @ PHI | 58 | W 3-0 | 33-25 | 2 | 20,595 | Mike McCormick | Jack Meyer | Mike McCormick | Jack Meyer | | 301 | 239 | 62 |
| 1959-06-13 | @ PHI | 59 | W 2-1 | 34-25 | 2 | 18,941 | Johnny Antonelli | Ray Semproch | Johnny Antonelli | Ray Semproch | | 303 | 240 | 63 |
| 1959-06-14 | @ PHI | 60 | L 5-7 | 34-27 | 2 | 0 | Sam Jones | Gene Conley | Humberto Robinson | Sam Jones | | 308 | 247 | 61 |
| 1959-06-14 | @ PHI | 61 | L 3-6 | 34-27 | 2 | 21,562 | Joe Shipley | Robin Roberts | Robin Roberts | Stu Miller | | 311 | 253 | 58 |
| 1959-06-16 | vs CIN | 62 | L 1-2 | 34-28 | 2 | 20,939 | Mike McCormick | Don Newcombe | Don Newcombe | Mike McCormick | | 312 | 255 | 57 |
| 1959-06-17 | vs CIN | 63 | W 7-5 | 35-28 | 2 | 13,037 | Johnny Antonelli | Orlando Pena | Johnny Antonelli | Orlando Pena | Sam Jones | 319 | 260 | 59 |
| 1959-06-18 | vs CIN | 64 | W 8-3 | 36-28 | 2 | 11,449 | Al Worthington | Joe Nuxhall | Stu Miller | Joe Nuxhall | | 327 | 263 | 64 |
| 1959-06-19 | vs MLN | 65 | W 4-3 | 37-28 | 2 | 22,984 | Sam Jones | Bob Buhl | Sam Jones | Bob Buhl | | 331 | 266 | 65 |
| 1959-06-20 | vs MLN | 66 | L 1-4 | 37-29 | 2 | 22,905 | Mike McCormick | Lew Burdette | Lew Burdette | Mike McCormick | | 332 | 270 | 62 |
| 1959-06-21 | vs MLN | 67 | L 3-13 | 37-30 | 2 | 22,934 | Johnny Antonelli | Warren Spahn | Warren Spahn | Johnny Antonelli | | 335 | 283 | 52 |
| 1959-06-22 | vs PIT | 68 | W 4-1 | 38-30 | 2 | 11,002 | Eddie Fisher | Ron Kline | Eddie Fisher | Ron Kline | Al Worthington | 339 | 284 | 55 |
| 1959-06-23 | vs PIT | 69 | L 1-5 | 38-31 | 2 | 22,706 | Sam Jones | Vern Law | Vern Law | Sam Jones | | 340 | 289 | 51 |
| 1959-06-24 | vs PIT | 70 | W 4-3 | 39-31 | 2 | 12,643 | Johnny Antonelli | Bob Friend | Mike McCormick | Bennie Daniels | | 344 | 292 | 52 |
| 1959-06-25 | vs PIT | 71 | L 1-3 | 39-32 | 2 | 11,487 | Stu Miller | Harvey Haddix | Roy Face | Eddie Fisher | | 345 | 295 | 50 |
| 1959-06-26 | vs PHI | 72 | W 8-0 | 40-32 | 2 | 15,816 | Mike McCormick | Jim Owens | Mike McCormick | Jim Owens | | 353 | 295 | 58 |
| 1959-06-27 | vs PHI | 73 | L 4-7 | 40-33 | 3 | 16,194 | Eddie Fisher | Gene Conley | Gene Conley | Sam Jones | | 357 | 302 | 55 |
| 1959-06-28 | vs PHI | 74 | W 6-0 | 41-33 | 3 | 20,793 | Johnny Antonelli | Ray Semproch | Johnny Antonelli | Ray Semproch | | 363 | 302 | 61 |
| 1959-06-29 | @ LAN | 75 | W 6-4 | 42-33 | 2 | 44,771 | Jack Sanford | Roger Craig | Mike McCormick | Stan Williams | | 369 | 306 | 63 |
| 1959-06-30 | @ LAN | 76 | W 2-0 | 43-33 | 2 | 59,312 | Sam Jones | Don Drysdale | Sam Jones | Don Drysdale | | 371 | 306 | 65 |
| 1959-07-02 | @ CHN | 77 | L 4-10 | 43-34 | 2 | 12,320 | Eddie Fisher | Glen Hobbie | Glen Hobbie | Eddie Fisher | Don Elston | 375 | 316 | 59 |
| 1959-07-03 | @ CHN | 78 | W 4-0 | 44-34 | 2 | 19,386 | Johnny Antonelli | Dave Hillman | Johnny Antonelli | Dave Hillman | | 379 | 316 | 63 |
| 1959-07-04 | @ SLN | 79 | W 10-3 | 45-34 | 2 | 18,211 | Mike McCormick | Larry Jackson | Mike McCormick | Larry Jackson | Stu Miller | 389 | 319 | 70 |
| 1959-07-05 | @ SLN | 80 | L 2-4 | 46-35 | 2 | 0 | Jack Sanford | Ernie Broglio | Ernie Broglio | Jack Sanford | | 391 | 323 | 68 |
| 1959-07-05 | @ SLN | 81 | W 4-2 | 46-35 | 2 | 28,431 | Sam Jones | Gary Blaylock | Sam Jones | Gary Blaylock | Johnny Antonelli | 395 | 325 | 70 |
| 1959-07-09 | @ CIN | 82 | W 3-2 | 47-35 | 2 | 14,705 | Mike McCormick | Don Newcombe | Sam Jones | Tom Acker | | 398 | 327 | 71 |
| 1959-07-10 | @ CIN | 83 | W 8-6 | 48-35 | 2 | 16,006 | Stu Miller | Jim O'Toole | Sam Jones | Orlando Pena | Eddie Fisher | 406 | 333 | 73 |
| 1959-07-11 | @ CIN | 84 | W 5-3 | 49-35 | 1 | 6,560 | Johnny Antonelli | Jim Brosnan | Johnny Antonelli | Jim Brosnan | | 411 | 336 | 75 |
| 1959-07-12 | @ MLN | 85 | L 2-4 | 49-36 | 2 | 40,953 | Jack Sanford | Lew Burdette | Lew Burdette | Jack Sanford | | 413 | 340 | 73 |
| 1959-07-13 | @ MLN | 86 | L 0-3 | 49-37 | 2 | 35,386 | Sam Jones | Warren Spahn | Warren Spahn | Sam Jones | | 413 | 343 | 70 |
| 1959-07-16 | @ PHI | 87 | L 4-6 | 50-38 | 1 | 0 | Mike McCormick | Robin Roberts | Robin Roberts | Jack Sanford | | 417 | 349 | 68 |
| 1959-07-16 | @ PHI | 88 | W 1-0 | 50-38 | 1 | 22,159 | Johnny Antonelli | Gene Conley | Johnny Antonelli | Gene Conley | | 418 | 349 | 69 |
| 1959-07-17 | @ PIT | 89 | W 4-1 | 51-38 | 1 | 33,220 | Sam Jones | Ron Kline | Sam Jones | Ron Kline | | 422 | 350 | 72 |
| 1959-07-18 | @ PIT | 90 | W 4-3 | 52-38 | 1 | 20,577 | Eddie Fisher | Harvey Haddix | Eddie Fisher | Harvey Haddix | Mike McCormick | 426 | 353 | 73 |
| 1959-07-19 | @ PIT | 91 | L 2-3 | 52-39 | 1 | 27,992 | Stu Miller | Vern Law | Vern Law | Stu Miller | | 428 | 356 | 72 |
| 1959-07-20 | vs LAN | 92 | L 2-3 | 52-40 | 1 | 22,777 | Johnny Antonelli | Don Drysdale | Don Drysdale | Johnny Antonelli | | 430 | 359 | 71 |
| 1959-07-21 | vs LAN | 93 | L 0-1 | 52-41 | 1 | 22,252 | Sam Jones | Roger Craig | Roger Craig | Sam Jones | | 430 | 360 | 70 |
| 1959-07-22 | vs SLN | 94 | W 6-1 | 53-41 | 1 | 20,949 | Mike McCormick | Dick Ricketts | Mike McCormick | Dick Ricketts | | 436 | 361 | 75 |
| 1959-07-23 | vs SLN | 95 | W 5-1 | 54-41 | 1 | 12,516 | Jack Sanford | Vinegar Bend Mizell | Jack Sanford | Vinegar Bend Mizell | | 441 | 362 | 79 |
| 1959-07-24 | vs CHN | 96 | W 6-5 | 55-41 | 1 | 22,865 | Johnny Antonelli | Dave Hillman | Sam Jones | Don Elston | | 447 | 367 | 80 |
| 1959-07-25 | vs CHN | 97 | L 3-5 | 55-42 | 1 | 20,261 | Stu Miller | Art Ceccarelli | Art Ceccarelli | Stu Miller | | 450 | 372 | 78 |
| 1959-07-26 | vs CHN | 98 | L 3-7 | 55-43 | 1 | 22,715 | Mike McCormick | Bob Anderson | Bob Anderson | Mike McCormick | | 453 | 379 | 74 |
| 1959-07-28 | vs PHI | 99 | L 2-3 | 55-44 | 1 | 15,350 | Sam Jones | Jim Owens | Jim Owens | Stu Miller | | 455 | 382 | 73 |
| 1959-07-29 | vs PHI | 100 | L 1-3 | 55-45 | 2 | 10,865 | Johnny Antonelli | Don Cardwell | Don Cardwell | Johnny Antonelli | | 456 | 385 | 71 |
| 1959-07-30 | vs PHI | 101 | W 7-2 | 56-45 | 1 | 10,114 | Mike McCormick | Robin Roberts | Mike McCormick | Robin Roberts | | 463 | 387 | 76 |
| 1959-07-31 | vs PIT | 102 | W 4-3 | 57-45 | 1 | 22,371 | Jack Sanford | Harvey Haddix | Jack Sanford | Harvey Haddix | | 467 | 390 | 77 |
| 1959-08-01 | vs PIT | 103 | W 9-5 | 58-45 | 1 | 21,567 | Sam Jones | Red Witt | Bud Byerly | Bennie Daniels | Stu Miller | 476 | 395 | 81 |
| 1959-08-02 | vs PIT | 104 | W 5-3 | 59-45 | 1 | 22,653 | Johnny Antonelli | Ron Kline | Johnny Antonelli | Bob Porterfield | | 481 | 398 | 83 |
| 1959-08-04 | vs MLN | 105 | L 1-6 | 59-46 | 2 | 22,959 | Mike McCormick | Warren Spahn | Warren Spahn | Mike McCormick | | 482 | 404 | 78 |
| 1959-08-05 | vs MLN | 106 | W 4-1 | 60-46 | 1 | 22,807 | Jack Sanford | Bob Buhl | Jack Sanford | Bob Buhl | | 486 | 405 | 81 |
| 1959-08-06 | vs MLN | 107 | W 7-1 | 61-46 | 1 | 22,923 | Sam Jones | Lew Burdette | Sam Jones | Lew Burdette | | 493 | 406 | 87 |
| 1959-08-07 | vs CIN | 108 | W 3-2 | 62-46 | 1 | 22,794 | Johnny Antonelli | Jim O'Toole | Johnny Antonelli | Brooks Lawrence | | 496 | 408 | 88 |
| 1959-08-08 | vs CIN | 109 | L 6-9 | 62-47 | 1 | 21,576 | Mike McCormick | Jay Hook | Orlando Pena | Mike McCormick | Jim Brosnan | 502 | 417 | 85 |
| 1959-08-09 | vs CIN | 110 | W 4-3 | 63-47 | 1 | 22,689 | Jack Sanford | Don Newcombe | Jack Sanford | Don Newcombe | | 506 | 420 | 86 |
| 1959-08-10 | @ SLN | 111 | W 3-2 | 64-47 | 1 | 17,576 | Sam Jones | Larry Jackson | Stu Miller | Larry Jackson | Mike McCormick | 509 | 422 | 87 |
| 1959-08-11 | @ SLN | 112 | W 5-4 | 65-47 | 1 | 16,526 | Johnny Antonelli | Vinegar Bend Mizell | Stu Miller | Lindy McDaniel | | 514 | 426 | 88 |
| 1959-08-13 | @ CHN | 113 | L 9-20 | 65-48 | 1 | 17,963 | Jack Sanford | Art Ceccarelli | Ed Donnelly | Eddie Fisher | Don Elston | 523 | 446 | 77 |
| 1959-08-14 | @ CHN | 114 | L 5-7 | 65-49 | 1 | 14,176 | Sam Jones | Glen Hobbie | Glen Hobbie | Sam Jones | Bill Henry | 528 | 453 | 75 |
| 1959-08-15 | @ CHN | 115 | W 6-4 | 66-49 | 1 | 24,070 | Jack Sanford | Moe Drabowsky | Jack Sanford | Moe Drabowsky | | 534 | 457 | 77 |
| 1959-08-16 | @ CHN | 116 | L 4-5 | 66-50 | 1 | 19,992 | Johnny Antonelli | Bob Anderson | Bob Anderson | Johnny Antonelli | Don Elston | 538 | 462 | 76 |
| 1959-08-17 | @ CIN | 117 | W 6-3 | 67-50 | 1 | 20,807 | Mike McCormick | Jim O'Toole | Stu Miller | Jim O'Toole | Sam Jones | 544 | 465 | 79 |
| 1959-08-18 | @ CIN | 118 | L 0-7 | 67-51 | 1 | 10,558 | Eddie Fisher | Don Newcombe | Don Newcombe | Eddie Fisher | | 544 | 472 | 72 |
| 1959-08-19 | @ MLN | 119 | L 2-5 | 67-52 | 1 | 32,966 | Jack Sanford | Lew Burdette | Lew Burdette | Jack Sanford | | 546 | 477 | 69 |
| 1959-08-20 | @ MLN | 120 | W 5-3 | 68-52 | 1 | 33,846 | Sam Jones | Warren Spahn | Sam Jones | Warren Spahn | | 551 | 480 | 71 |
| 1959-08-21 | @ PHI | 121 | W 6-0 | 70-52 | 1 | 0 | Johnny Antonelli | Robin Roberts | Johnny Antonelli | Robin Roberts | | 557 | 480 | 77 |
| 1959-08-21 | @ PHI | 122 | W 10-6 | 70-52 | 1 | 28,164 | Mike McCormick | Ray Semproch | Mike McCormick | Ray Semproch | Stu Miller | 567 | 486 | 81 |
| 1959-08-22 | @ PHI | 123 | W 8-1 | 71-52 | 1 | 9,888 | Al Worthington | Jim Owens | Al Worthington | Jim Owens | Gordon Jones | 575 | 487 | 88 |
| 1959-08-24 | @ PIT | 124 | L 0-6 | 71-53 | 1 | 23,617 | Sam Jones | Bob Friend | Bob Friend | Sam Jones | | 575 | 493 | 82 |
| 1959-08-25 | @ PIT | 125 | W 12-5 | 72-53 | 1 | 29,927 | Johnny Antonelli | Ron Kline | Johnny Antonelli | Ron Kline | | 587 | 498 | 89 |
| 1959-08-26 | @ PIT | 126 | L 4-5 | 72-54 | 1 | 20,244 | Jack Sanford | Bennie Daniels | Ron Kline | Stu Miller | | 591 | 503 | 88 |
| 1959-08-27 | @ PHI | 127 | L 2-7 | 72-56 | 1 | 0 | Mike McCormick | Jim Owens | Jim Owens | Mike McCormick | | 593 | 510 | 83 |
| 1959-08-27 | @ PHI | 128 | L 1-2 | 72-56 | 1 | 14,538 | Al Worthington | Don Cardwell | Don Cardwell | Al Worthington | Turk Farrell | 594 | 512 | 82 |
| 1959-08-28 | @ LAN | 129 | W 5-0 | 73-56 | 1 | 66,068 | Sam Jones | Don Drysdale | Sam Jones | Don Drysdale | | 599 | 512 | 87 |
| 1959-08-30 | @ LAN | 130 | L 6-7 | 73-57 | 1 | 44,391 | Johnny Antonelli | Larry Sherry | Roger Craig | Mike McCormick | | 605 | 519 | 86 |
| 1959-08-31 | @ LAN | 131 | L 2-5 | 73-58 | 1 | 60,194 | Jack Sanford | Sandy Koufax | Sandy Koufax | Jack Sanford | | 607 | 524 | 83 |
| 1959-09-02 | vs CHN | 132 | W 4-3 | 74-58 | 1 | 16,422 | Mike McCormick | Art Ceccarelli | Sam Jones | Don Elston | | 611 | 527 | 84 |
| 1959-09-03 | vs CHN | 133 | W 8-5 | 75-58 | 1 | 15,424 | Johnny Antonelli | Bob Anderson | Stu Miller | Dave Hillman | | 619 | 532 | 87 |
| 1959-09-04 | vs CHN | 134 | L 1-2 | 75-59 | 1 | 22,850 | Jack Sanford | Glen Hobbie | Glen Hobbie | Jack Sanford | | 620 | 534 | 86 |
| 1959-09-05 | vs SLN | 135 | W 3-2 | 76-59 | 1 | 20,829 | Johnny Antonelli | Vinegar Bend Mizell | Johnny Antonelli | Vinegar Bend Mizell | | 623 | 536 | 87 |
| 1959-09-06 | vs SLN | 136 | L 0-1 | 76-60 | 1 | 22,893 | Mike McCormick | Larry Jackson | Larry Jackson | Mike McCormick | | 623 | 537 | 86 |
| 1959-09-07 | vs SLN | 137 | W 4-2 | 77-60 | 1 | 22,815 | Sam Jones | Bob Gibson | Sam Jones | Bob Gibson | | 627 | 539 | 88 |
| 1959-09-09 | vs PIT | 138 | W 7-2 | 78-60 | 1 | 22,768 | Jack Sanford | Harvey Haddix | Jack Sanford | Harvey Haddix | Stu Miller | 634 | 541 | 93 |
| 1959-09-10 | vs PIT | 139 | L 3-5 | 78-61 | 1 | 14,130 | Johnny Antonelli | Vern Law | Vern Law | Johnny Antonelli | | 637 | 546 | 91 |
| 1959-09-11 | vs PHI | 140 | L 0-1 | 78-62 | 1 | 22,222 | Mike McCormick | Robin Roberts | Robin Roberts | Mike McCormick | | 637 | 547 | 90 |
| 1959-09-12 | vs PHI | 141 | W 9-1 | 79-62 | 1 | 21,133 | Sam Jones | Humberto Robinson | Sam Jones | Humberto Robinson | | 646 | 548 | 98 |
| 1959-09-13 | vs PHI | 142 | W 1-0 | 80-62 | 1 | 21,841 | Jack Sanford | Don Cardwell | Jack Sanford | Don Cardwell | Mike McCormick | 647 | 548 | 99 |
| 1959-09-14 | vs CIN | 143 | L 1-4 | 80-63 | 1 | 10,217 | Johnny Antonelli | Jim Brosnan | Jim Brosnan | Johnny Antonelli | Brooks Lawrence | 648 | 552 | 96 |
| 1959-09-15 | vs CIN | 144 | W 13-6 | 81-63 | 1 | 11,814 | Mike McCormick | Jay Hook | Mike McCormick | Jay Hook | | 661 | 558 | 103 |
| 1959-09-16 | vs MLN | 145 | L 0-2 | 81-64 | 1 | 22,721 | Sam Jones | Lew Burdette | Lew Burdette | Sam Jones | | 661 | 560 | 101 |
| 1959-09-17 | vs MLN | 146 | W 13-6 | 82-64 | 1 | 21,617 | Jack Sanford | Warren Spahn | Jack Sanford | Warren Spahn | Sam Jones | 674 | 566 | 108 |
| 1959-09-19 | vs LAN | 147 | L 1-4 | 82-66 | 2 | 22,823 | Johnny Antonelli | Roger Craig | Roger Craig | Johnny Antonelli | | 675 | 570 | 105 |
| 1959-09-19 | vs LAN | 148 | L 3-5 | 82-66 | 2 | 22,737 | Mike McCormick | Don Drysdale | Don Drysdale | Mike McCormick | Chuck Churn | 678 | 575 | 103 |
| 1959-09-20 | vs LAN | 149 | L 2-8 | 82-67 | 3 | 22,923 | Sam Jones | Johnny Podres | Johnny Podres | Sam Jones | Clem Labine | 680 | 583 | 97 |
| 1959-09-22 | @ CHN | 150 | L 4-5 | 82-68 | 3 | 5,442 | Jack Sanford | Dave Hillman | Don Elston | Sam Jones | | 684 | 588 | 96 |
| 1959-09-23 | @ CHN | 151 | L 8-9 | 82-69 | 3 | 4,940 | Johnny Antonelli | Bob Anderson | Don Elston | Eddie Fisher | | 692 | 597 | 95 |
| 1959-09-26 | @ SLN | 152 | W 4-0 | 83-69 | 3 | 9,860 | Sam Jones | Vinegar Bend Mizell | Sam Jones | Vinegar Bend Mizell | | 696 | 597 | 99 |
| 1959-09-27 | @ SLN | 153 | L 1-2 | 83-71 | 3 | 0 | Mike McCormick | Larry Jackson | Larry Jackson | Mike McCormick | Lindy McDaniel | 697 | 599 | 98 |
| 1959-09-27 | @ SLN | 154 | L 8-14 | 83-71 | 3 | 19,477 | Marshall Renfroe | Bob Miller | Bob Gibson | Eddie Fisher | | 705 | 613 | 92 |