| 1959-04-10 | @ PIT | 1 | W 8-0 | 1-0 | 3 | 33,317 | Warren Spahn | Bob Friend | Warren Spahn | Bob Friend | | 8 | 0 | 8 |
| 1959-04-11 | @ PIT | 2 | W 4-3 | 2-0 | 4 | 11,800 | Lew Burdette | Vern Law | Lew Burdette | Vern Law | | 12 | 3 | 9 |
| 1959-04-14 | vs PHI | 3 | W 4-3 | 3-0 | 1 | 42,081 | Warren Spahn | Jim Owens | Don McMahon | Turk Farrell | | 16 | 6 | 10 |
| 1959-04-16 | vs PHI | 4 | W 7-3 | 4-0 | 1 | 11,186 | Lew Burdette | Robin Roberts | Lew Burdette | Jack Meyer | | 23 | 9 | 14 |
| 1959-04-17 | vs PIT | 5 | W 2-2 | 5-0 | 1 | 8,562 | Bob Rush | Harvey Haddix | | | | 25 | 11 | 14 |
| 1959-04-18 | vs PIT | 6 | L 5-11 | 5-1 | 1 | 15,703 | Bob Buhl | Vern Law | Vern Law | Bob Buhl | | 30 | 22 | 8 |
| 1959-04-21 | vs CIN | 7 | W 7-4 | 6-1 | 1 | 6,869 | Warren Spahn | Bob Purkey | Warren Spahn | Bob Purkey | | 37 | 26 | 11 |
| 1959-04-22 | @ PHI | 8 | W 2-0 | 7-1 | 1 | 14,228 | Lew Burdette | Robin Roberts | Lew Burdette | Robin Roberts | | 39 | 26 | 13 |
| 1959-04-23 | @ PHI | 9 | L 3-4 | 7-2 | 1 | 8,689 | Juan Pizarro | Ray Semproch | Ray Semproch | Juan Pizarro | | 42 | 30 | 12 |
| 1959-04-24 | @ CIN | 10 | W 10-7 | 8-2 | 1 | 14,874 | Joey Jay | Don Newcombe | Joey Jay | Don Newcombe | Don McMahon | 52 | 37 | 15 |
| 1959-04-25 | @ CIN | 11 | L 6-7 | 8-3 | 1 | 5,612 | Warren Spahn | Bob Purkey | Tom Acker | Warren Spahn | Bob Mabe | 58 | 44 | 14 |
| 1959-04-26 | @ CIN | 12 | L 10-11 | 8-4 | 1 | 14,925 | Lew Burdette | Joe Nuxhall | Bob Purkey | Warren Spahn | | 68 | 55 | 13 |
| 1959-04-29 | vs SLN | 13 | W 9-3 | 9-4 | 1 | 13,852 | Lew Burdette | Larry Jackson | Lew Burdette | Larry Jackson | | 77 | 58 | 19 |
| 1959-04-30 | vs SLN | 14 | W 1-0 | 10-4 | 1 | 12,086 | Warren Spahn | Alex Kellner | Warren Spahn | Alex Kellner | | 78 | 58 | 20 |
| 1959-05-01 | vs SFN | 15 | L 4-6 | 10-5 | 1 | 16,900 | Carl Willey | Sam Jones | Sam Jones | Carl Willey | Stu Miller | 82 | 64 | 18 |
| 1959-05-02 | vs SFN | 16 | L 5-8 | 10-6 | 1 | 20,127 | Joey Jay | Jack Sanford | Jack Sanford | Joey Jay | Gordon Jones | 87 | 72 | 15 |
| 1959-05-03 | vs SFN | 17 | W 9-4 | 11-6 | 1 | 22,911 | Lew Burdette | Johnny Antonelli | Lew Burdette | Johnny Antonelli | | 96 | 76 | 20 |
| 1959-05-04 | vs LAN | 18 | L 3-5 | 11-7 | 1 | 15,262 | Warren Spahn | Johnny Podres | Johnny Podres | Warren Spahn | Art Fowler | 99 | 81 | 18 |
| 1959-05-05 | vs LAN | 19 | W 3-2 | 12-7 | 1 | 0 | Carl Willey | Don Drysdale | Bob Rush | Clem Labine | | 102 | 83 | 19 |
| 1959-05-06 | vs LAN | 20 | W 5-4 | 13-7 | 1 | 0 | Joey Jay | Gene Snyder | Bob Giggie | Art Fowler | Bob Trowbridge | 107 | 87 | 20 |
| 1959-05-08 | vs CIN | 21 | L 2-3 | 13-8 | 1 | 16,624 | Lew Burdette | Brooks Lawrence | Brooks Lawrence | Lew Burdette | | 109 | 90 | 19 |
| 1959-05-09 | vs CIN | 22 | L 0-3 | 13-9 | 2 | 15,745 | Warren Spahn | Bob Purkey | Bob Purkey | Warren Spahn | | 109 | 93 | 16 |
| 1959-05-10 | vs CIN | 23 | W 12-4 | 15-9 | 1 | 0 | Bob Rush | Don Newcombe | Bob Rush | Don Newcombe | Don McMahon | 121 | 97 | 24 |
| 1959-05-10 | vs CIN | 24 | W 2-1 | 15-9 | 1 | 25,334 | Carl Willey | Joe Nuxhall | Carl Willey | Joe Nuxhall | | 123 | 98 | 25 |
| 1959-05-11 | @ CHN | 25 | W 8-1 | 15-9 | 1 | 7,995 | Bob Buhl | Moe Drabowsky | Bob Buhl | Moe Drabowsky | Bob Giggie | 131 | 99 | 32 |
| 1959-05-12 | @ CHN | 26 | L 3-7 | 15-10 | 2 | 8,288 | Lew Burdette | Bob Anderson | Don Elston | Lew Burdette | | 134 | 106 | 28 |
| 1959-05-13 | @ SLN | 27 | W 3-2 | 16-10 | 1 | 8,737 | Warren Spahn | Larry Jackson | Warren Spahn | Larry Jackson | | 137 | 108 | 29 |
| 1959-05-14 | @ SLN | 28 | W 8-7 | 17-10 | 1 | 7,356 | Juan Pizarro | Lindy McDaniel | Bob Rush | Howie Nunn | Lew Burdette | 145 | 115 | 30 |
| 1959-05-16 | @ LAN | 29 | W 6-0 | 18-10 | 1 | 54,389 | Bob Buhl | Danny McDevitt | Bob Buhl | Danny McDevitt | | 151 | 115 | 36 |
| 1959-05-17 | @ LAN | 30 | W 8-3 | 19-10 | 1 | 49,347 | Lew Burdette | Don Drysdale | Lew Burdette | Don Drysdale | | 159 | 118 | 41 |
| 1959-05-18 | @ SFN | 31 | W 4-2 | 20-10 | 1 | 17,524 | Warren Spahn | Sam Jones | Warren Spahn | Sam Jones | | 163 | 120 | 43 |
| 1959-05-19 | @ SFN | 32 | W 8-1 | 21-10 | 1 | 22,910 | Joey Jay | Jack Sanford | Joey Jay | Jack Sanford | | 171 | 121 | 50 |
| 1959-05-20 | @ SFN | 33 | L 3-6 | 21-11 | 1 | 17,825 | Bob Buhl | Mike McCormick | Mike McCormick | Bob Buhl | Sam Jones | 174 | 127 | 47 |
| 1959-05-22 | @ PHI | 34 | W 10-5 | 22-11 | 1 | 24,043 | Lew Burdette | Robin Roberts | Lew Burdette | Robin Roberts | | 184 | 132 | 52 |
| 1959-05-23 | @ PHI | 35 | L 2-4 | 22-12 | 1 | 8,346 | Warren Spahn | Jim Owens | Jim Owens | Warren Spahn | | 186 | 136 | 50 |
| 1959-05-24 | @ PHI | 36 | L 0-6 | 23-13 | 1 | 0 | Joey Jay | Gene Conley | Gene Conley | Joey Jay | | 186 | 142 | 44 |
| 1959-05-24 | @ PHI | 37 | W 8-3 | 23-13 | 1 | 26,646 | Carl Willey | Ray Semproch | Carl Willey | Taylor Phillips | | 194 | 145 | 49 |
| 1959-05-25 | @ PHI | 38 | L 3-7 | 23-14 | 1 | 16,681 | Bob Buhl | Don Cardwell | Don Cardwell | Bob Buhl | Ray Semproch | 197 | 152 | 45 |
| 1959-05-26 | vs PIT | 39 | W 1-0 | 24-14 | 1 | 19,194 | Lew Burdette | Harvey Haddix | Lew Burdette | Harvey Haddix | | 198 | 152 | 46 |
| 1959-05-27 | vs PIT | 40 | W 4-3 | 25-14 | 1 | 17,721 | Warren Spahn | Vern Law | Warren Spahn | Vern Law | Don McMahon | 202 | 155 | 47 |
| 1959-05-28 | vs PIT | 41 | L 0-3 | 25-15 | 1 | 12,635 | Joey Jay | Bob Friend | Bob Friend | Joey Jay | | 202 | 158 | 44 |
| 1959-05-29 | vs PHI | 42 | W 6-5 | 26-15 | 1 | 20,334 | Carl Willey | Gene Conley | Don McMahon | Gene Conley | | 208 | 163 | 45 |
| 1959-05-30 | vs PHI | 43 | W 4-2 | 27-15 | 1 | 18,945 | Bob Buhl | Don Cardwell | Bob Buhl | Don Cardwell | | 212 | 165 | 47 |
| 1959-05-31 | vs PHI | 44 | L 0-6 | 28-16 | 1 | 0 | Lew Burdette | Robin Roberts | Robin Roberts | Lew Burdette | | 212 | 171 | 41 |
| 1959-05-31 | vs PHI | 45 | W 2-1 | 28-16 | 1 | 28,590 | Warren Spahn | Ray Semproch | Warren Spahn | Ray Semproch | | 214 | 172 | 42 |
| 1959-06-01 | vs SFN | 46 | L 2-11 | 28-17 | 1 | 16,666 | Joey Jay | Sam Jones | Sam Jones | Joey Jay | | 216 | 183 | 33 |
| 1959-06-02 | vs SFN | 47 | W 3-0 | 29-17 | 1 | 20,364 | Bob Rush | Stu Miller | Bob Rush | Stu Miller | | 219 | 183 | 36 |
| 1959-06-03 | vs SFN | 48 | W 7-4 | 30-17 | 1 | 23,071 | Bob Buhl | Jack Sanford | Bob Buhl | Jack Sanford | Don McMahon | 226 | 187 | 39 |
| 1959-06-04 | vs SFN | 49 | L 5-11 | 30-18 | 1 | 16,713 | Lew Burdette | Mike McCormick | Gordon Jones | Lew Burdette | Stu Miller | 231 | 198 | 33 |
| 1959-06-05 | vs LAN | 50 | L 1-5 | 30-19 | 1 | 30,826 | Warren Spahn | Johnny Podres | Johnny Podres | Warren Spahn | | 232 | 203 | 29 |
| 1959-06-06 | vs LAN | 51 | L 2-3 | 30-20 | 1 | 26,699 | Bob Rush | Sandy Koufax | Sandy Koufax | Bob Rush | Clem Labine | 234 | 206 | 28 |
| 1959-06-07 | vs LAN | 52 | W 8-2 | 31-20 | 1 | 32,399 | Bob Buhl | Don Drysdale | Bob Buhl | Don Drysdale | | 242 | 208 | 34 |
| 1959-06-08 | vs CHN | 53 | W 9-5 | 32-20 | 1 | 12,288 | Lew Burdette | Seth Morehead | Lew Burdette | Seth Morehead | Don McMahon | 251 | 213 | 38 |
| 1959-06-09 | @ SLN | 54 | L 3-12 | 32-21 | 1 | 13,014 | Warren Spahn | Larry Jackson | Larry Jackson | Warren Spahn | | 254 | 225 | 29 |
| 1959-06-10 | @ SLN | 55 | L 2-5 | 32-22 | 1 | 15,195 | Bob Rush | Alex Kellner | Alex Kellner | Bob Rush | Lindy McDaniel | 256 | 230 | 26 |
| 1959-06-11 | @ SLN | 56 | W 8-0 | 33-22 | 1 | 11,414 | Bob Buhl | Vinegar Bend Mizell | Bob Buhl | Vinegar Bend Mizell | | 264 | 230 | 34 |
| 1959-06-12 | @ CHN | 57 | L 7-9 | 33-23 | 1 | 11,873 | Lew Burdette | John Buzhardt | John Buzhardt | Lew Burdette | Bill Henry | 271 | 239 | 32 |
| 1959-06-13 | @ CHN | 58 | W 4-2 | 34-23 | 1 | 23,583 | Warren Spahn | Bob Anderson | Warren Spahn | Bob Anderson | Don McMahon | 275 | 241 | 34 |
| 1959-06-14 | @ CHN | 59 | L 0-6 | 34-23 | 1 | 36,895 | Bob Rush | Dick Drott | Dick Drott | Bob Rush | | 275 | 247 | 28 |
| 1959-06-15 | @ LAN | 60 | L 0-4 | 34-24 | 1 | 24,792 | Bob Buhl | Don Drysdale | Don Drysdale | Bob Buhl | | 275 | 251 | 24 |
| 1959-06-16 | @ LAN | 61 | W 5-4 | 35-24 | 1 | 31,366 | Lew Burdette | Johnny Podres | Lew Burdette | Johnny Podres | Don McMahon | 280 | 255 | 25 |
| 1959-06-17 | @ LAN | 62 | L 2-10 | 35-26 | 1 | 0 | Warren Spahn | Sandy Koufax | Sandy Koufax | Warren Spahn | | 282 | 265 | 17 |
| 1959-06-17 | @ LAN | 63 | L 0-4 | 35-26 | 1 | 54,999 | Joey Jay | Danny McDevitt | Danny McDevitt | Joey Jay | | 282 | 269 | 13 |
| 1959-06-18 | @ LAN | 64 | W 7-6 | 36-26 | 1 | 52,278 | Bob Rush | Stan Williams | Bob Trowbridge | Stan Williams | Don McMahon | 289 | 275 | 14 |
| 1959-06-19 | @ SFN | 65 | L 3-4 | 36-27 | 1 | 22,984 | Bob Buhl | Sam Jones | Sam Jones | Bob Buhl | | 292 | 279 | 13 |
| 1959-06-20 | @ SFN | 66 | W 4-1 | 37-27 | 1 | 22,905 | Lew Burdette | Mike McCormick | Lew Burdette | Mike McCormick | | 296 | 280 | 16 |
| 1959-06-21 | @ SFN | 67 | W 13-3 | 38-27 | 1 | 22,934 | Warren Spahn | Johnny Antonelli | Warren Spahn | Johnny Antonelli | | 309 | 283 | 26 |
| 1959-06-23 | vs SLN | 68 | W 9-5 | 39-27 | 1 | 24,839 | Carl Willey | Alex Kellner | Carl Willey | Hal Jeffcoat | | 318 | 288 | 30 |
| 1959-06-24 | vs SLN | 69 | W 4-0 | 40-27 | 1 | 19,166 | Joey Jay | Dick Ricketts | Joey Jay | Dick Ricketts | | 322 | 288 | 34 |
| 1959-06-25 | vs SLN | 70 | L 2-3 | 40-28 | 1 | 19,977 | Lew Burdette | Vinegar Bend Mizell | Lindy McDaniel | Lew Burdette | | 324 | 291 | 33 |
| 1959-06-26 | vs CHN | 71 | W 11-1 | 41-28 | 1 | 35,262 | Warren Spahn | John Buzhardt | Warren Spahn | John Buzhardt | | 335 | 292 | 43 |
| 1959-06-27 | vs CHN | 72 | L 1-7 | 41-28 | 1 | 26,881 | Carl Willey | Glen Hobbie | Glen Hobbie | Carl Willey | | 336 | 299 | 37 |
| 1959-06-28 | vs CHN | 73 | W 2-1 | 42-28 | 1 | 32,884 | Juan Pizarro | Dave Hillman | Juan Pizarro | Dave Hillman | | 338 | 300 | 38 |
| 1959-06-30 | @ CIN | 74 | L 5-8 | 42-29 | 1 | 14,990 | Lew Burdette | Bob Purkey | Bob Purkey | Lew Burdette | Orlando Pena | 343 | 308 | 35 |
| 1959-07-02 | @ PIT | 75 | L 3-4 | 42-30 | 1 | 28,282 | Warren Spahn | Vern Law | Vern Law | Don McMahon | | 346 | 312 | 34 |
| 1959-07-03 | @ PIT | 76 | W 6-0 | 43-30 | 1 | 34,093 | Juan Pizarro | Red Witt | Juan Pizarro | Red Witt | | 352 | 312 | 40 |
| 1959-07-04 | @ PHI | 77 | L 1-2 | 43-31 | 1 | 16,775 | Lew Burdette | Robin Roberts | Robin Roberts | Lew Burdette | | 353 | 314 | 39 |
| 1959-07-05 | @ PHI | 78 | W 5-0 | 44-31 | 1 | 9,768 | Carl Willey | Gene Conley | Carl Willey | Gene Conley | | 358 | 314 | 44 |
| 1959-07-09 | vs LAN | 79 | L 3-4 | 44-32 | 1 | 33,449 | Joey Jay | Danny McDevitt | Roger Craig | Warren Spahn | | 361 | 318 | 43 |
| 1959-07-11 | vs LAN | 80 | L 5-7 | 44-33 | 2 | 34,009 | Carl Willey | Sandy Koufax | Don Drysdale | Carl Willey | | 366 | 325 | 41 |
| 1959-07-12 | vs SFN | 81 | W 4-2 | 45-33 | 1 | 40,953 | Lew Burdette | Jack Sanford | Lew Burdette | Jack Sanford | | 370 | 327 | 43 |
| 1959-07-13 | vs SFN | 82 | W 3-0 | 46-33 | 1 | 35,386 | Warren Spahn | Sam Jones | Warren Spahn | Sam Jones | | 373 | 327 | 46 |
| 1959-07-14 | @ CHN | 83 | L 5-10 | 46-34 | 1 | 21,157 | Juan Pizarro | Bob Anderson | Bill Henry | Joey Jay | | 378 | 337 | 41 |
| 1959-07-15 | @ CHN | 84 | L 2-5 | 46-35 | 2 | 22,206 | Carl Willey | Glen Hobbie | Glen Hobbie | Carl Willey | | 380 | 342 | 38 |
| 1959-07-16 | @ CHN | 85 | L 2-4 | 46-36 | 2 | 23,678 | Lew Burdette | Dave Hillman | Dave Hillman | Lew Burdette | | 382 | 346 | 36 |
| 1959-07-17 | @ SLN | 86 | L 3-4 | 46-37 | 2 | 22,612 | Warren Spahn | Larry Jackson | Lindy McDaniel | Warren Spahn | | 385 | 350 | 35 |
| 1959-07-18 | @ SLN | 87 | L 5-6 | 46-38 | 2 | 27,406 | Bob Rush | Dick Ricketts | Marshall Bridges | Bob Buhl | | 390 | 356 | 34 |
| 1959-07-19 | @ SLN | 88 | L 5-9 | 46-39 | 3 | 27,559 | Juan Pizarro | Vinegar Bend Mizell | Vinegar Bend Mizell | Carl Willey | Marshall Bridges | 395 | 365 | 30 |
| 1959-07-21 | vs CIN | 89 | L 2-12 | 46-40 | 3 | 24,447 | Lew Burdette | Don Newcombe | Don Newcombe | Lew Burdette | | 397 | 377 | 20 |
| 1959-07-22 | vs CIN | 90 | W 5-4 | 47-40 | 3 | 18,843 | Warren Spahn | Jim O'Toole | Warren Spahn | Jim O'Toole | | 402 | 381 | 21 |
| 1959-07-23 | vs CIN | 91 | L 2-6 | 47-41 | 3 | 16,423 | Joey Jay | Bob Purkey | Brooks Lawrence | Joey Jay | | 404 | 387 | 17 |
| 1959-07-24 | vs PIT | 92 | W 8-0 | 47-41 | 3 | 27,708 | Juan Pizarro | Harvey Haddix | Juan Pizarro | Harvey Haddix | | 412 | 387 | 25 |
| 1959-07-25 | vs PIT | 93 | W 3-0 | 48-41 | 3 | 25,295 | Lew Burdette | Vern Law | Lew Burdette | Vern Law | | 415 | 387 | 28 |
| 1959-07-26 | vs PIT | 94 | W 4-0 | 50-41 | 2 | 0 | Warren Spahn | Bob Friend | Warren Spahn | Bob Friend | | 419 | 387 | 32 |
| 1959-07-26 | vs PIT | 95 | W 2-1 | 50-41 | 2 | 39,420 | Bob Buhl | Red Witt | Bob Buhl | Red Witt | Don McMahon | 421 | 388 | 33 |
| 1959-07-27 | vs PIT | 96 | W 5-2 | 51-41 | 2 | 15,817 | Joey Jay | Ron Kline | Joey Jay | Ron Kline | | 426 | 390 | 36 |
| 1959-07-28 | vs CHN | 97 | L 4-5 | 51-42 | 3 | 28,940 | Juan Pizarro | Glen Hobbie | Glen Hobbie | Carl Willey | Bill Henry | 430 | 395 | 35 |
| 1959-07-29 | vs CHN | 98 | W 8-5 | 51-42 | 3 | 21,236 | Lew Burdette | Dave Hillman | Lew Burdette | Dave Hillman | Don McMahon | 438 | 400 | 38 |
| 1959-07-30 | vs CHN | 99 | W 6-2 | 52-42 | 2 | 29,170 | Warren Spahn | Art Ceccarelli | Warren Spahn | Art Ceccarelli | | 444 | 402 | 42 |
| 1959-07-31 | vs SLN | 100 | W 6-0 | 53-42 | 2 | 29,287 | Bob Buhl | Dean Stone | Bob Buhl | Dean Stone | | 450 | 402 | 48 |
| 1959-08-01 | vs SLN | 101 | W 8-1 | 54-42 | 2 | 26,812 | Juan Pizarro | Ernie Broglio | Juan Pizarro | Ernie Broglio | | 458 | 403 | 55 |
| 1959-08-02 | vs SLN | 102 | L 3-4 | 55-43 | 2 | 0 | Joey Jay | Larry Jackson | Larry Jackson | Joey Jay | Lindy McDaniel | 461 | 407 | 54 |
| 1959-08-02 | vs SLN | 103 | W 11-5 | 55-43 | 2 | 42,732 | Lew Burdette | Vinegar Bend Mizell | Lew Burdette | Vinegar Bend Mizell | | 472 | 412 | 60 |
| 1959-08-04 | @ SFN | 104 | W 6-1 | 56-43 | 1 | 22,959 | Warren Spahn | Mike McCormick | Warren Spahn | Mike McCormick | | 478 | 413 | 65 |
| 1959-08-05 | @ SFN | 105 | L 1-4 | 56-44 | 2 | 22,807 | Bob Buhl | Jack Sanford | Jack Sanford | Bob Buhl | | 479 | 417 | 62 |
| 1959-08-06 | @ SFN | 106 | L 1-7 | 56-45 | 3 | 22,923 | Lew Burdette | Sam Jones | Sam Jones | Lew Burdette | | 480 | 424 | 56 |
| 1959-08-08 | @ LAN | 107 | L 2-4 | 56-46 | 3 | 67,312 | Joey Jay | Don Drysdale | Don Drysdale | Joey Jay | | 482 | 428 | 54 |
| 1959-08-09 | @ LAN | 108 | W 8-7 | 57-46 | 3 | 29,234 | Bob Buhl | Roger Craig | Bob Buhl | Roger Craig | Don McMahon | 490 | 435 | 55 |
| 1959-08-11 | @ CIN | 109 | L 3-4 | 58-47 | 3 | 0 | Warren Spahn | Joe Nuxhall | Joe Nuxhall | Warren Spahn | | 493 | 439 | 54 |
| 1959-08-11 | @ CIN | 110 | W 7-3 | 58-47 | 3 | 29,896 | Lew Burdette | Jay Hook | Lew Burdette | Jay Hook | | 500 | 442 | 58 |
| 1959-08-12 | @ CIN | 111 | W 6-4 | 59-47 | 2 | 13,221 | Juan Pizarro | Jim O'Toole | Bob Rush | Jim O'Toole | | 506 | 446 | 60 |
| 1959-08-13 | @ CIN | 112 | L 8-9 | 59-48 | 3 | 9,174 | Bob Buhl | Jim Brosnan | Jim Brosnan | Bob Buhl | Brooks Lawrence | 514 | 455 | 59 |
| 1959-08-14 | @ PIT | 113 | L 1-2 | 59-48 | 2 | 26,873 | Joey Jay | Vern Law | Vern Law | Joey Jay | | 515 | 457 | 58 |
| 1959-08-15 | @ PIT | 114 | L 8-10 | 59-49 | 3 | 34,478 | Lew Burdette | Ron Kline | Ron Kline | Lew Burdette | Fred Green | 523 | 467 | 56 |
| 1959-08-16 | @ PIT | 115 | W 5-2 | 59-49 | 3 | 24,518 | Warren Spahn | Bennie Daniels | Warren Spahn | Bennie Daniels | | 528 | 469 | 59 |
| 1959-08-16 | @ PIT | 116 | L 1-2 | 59-49 | 3 | 0 | Juan Pizarro | Bob Friend | Bob Friend | Juan Pizarro | Bob Porterfield | 529 | 471 | 58 |
| 1959-08-17 | vs LAN | 117 | W 8-1 | 60-50 | 3 | 0 | Bob Buhl | Sandy Koufax | Bob Buhl | Sandy Koufax | | 537 | 472 | 65 |
| 1959-08-17 | vs LAN | 118 | L 3-4 | 60-50 | 3 | 40,265 | Carl Willey | Stan Williams | Johnny Podres | Bob Rush | | 540 | 476 | 64 |
| 1959-08-18 | vs LAN | 119 | L 6-7 | 60-51 | 3 | 30,260 | Joey Jay | Don Drysdale | Larry Sherry | Warren Spahn | | 546 | 483 | 63 |
| 1959-08-19 | vs SFN | 120 | W 5-2 | 61-51 | 3 | 32,966 | Lew Burdette | Jack Sanford | Lew Burdette | Jack Sanford | | 551 | 485 | 66 |
| 1959-08-20 | vs SFN | 121 | L 3-5 | 61-52 | 3 | 33,846 | Warren Spahn | Sam Jones | Sam Jones | Warren Spahn | | 554 | 490 | 64 |
| 1959-08-22 | vs CHN | 122 | W 7-0 | 63-52 | 3 | 0 | Carl Willey | Glen Hobbie | Carl Willey | Glen Hobbie | | 561 | 490 | 71 |
| 1959-08-22 | vs CHN | 123 | W 3-2 | 63-52 | 3 | 36,211 | Joey Jay | Dave Hillman | Don McMahon | Don Elston | | 564 | 492 | 72 |
| 1959-08-23 | vs CHN | 124 | W 2-0 | 63-52 | 2 | 33,464 | Bob Buhl | Art Ceccarelli | Bob Buhl | Art Ceccarelli | | 566 | 492 | 74 |
| 1959-08-24 | vs CHN | 125 | L 0-3 | 63-53 | 3 | 27,381 | Lew Burdette | Bob Anderson | Bob Anderson | Lew Burdette | | 566 | 495 | 71 |
| 1959-08-25 | @ SLN | 126 | W 3-1 | 64-53 | 2 | 17,311 | Warren Spahn | Bob Gibson | Don McMahon | Bob Gibson | | 569 | 496 | 73 |
| 1959-08-26 | @ SLN | 127 | L 2-5 | 64-54 | 3 | 13,759 | Carl Willey | Larry Jackson | Larry Jackson | Carl Willey | | 571 | 501 | 70 |
| 1959-08-27 | @ SLN | 128 | L 4-5 | 64-55 | 3 | 13,772 | Bob Buhl | Vinegar Bend Mizell | Lindy McDaniel | Don McMahon | | 575 | 506 | 69 |
| 1959-08-28 | @ CHN | 129 | W 9-3 | 65-55 | 3 | 15,929 | Lew Burdette | Bob Anderson | Lew Burdette | Bob Anderson | | 584 | 509 | 75 |
| 1959-08-29 | @ CHN | 130 | W 11-4 | 66-55 | 2 | 0 | Warren Spahn | Moe Drabowsky | Warren Spahn | Bill Henry | | 595 | 513 | 82 |
| 1959-08-30 | @ CHN | 131 | L 2-6 | 66-56 | 3 | 28,158 | Carl Willey | Glen Hobbie | Glen Hobbie | Carl Willey | Bill Henry | 597 | 519 | 78 |
| 1959-09-01 | vs PHI | 132 | L 3-5 | 66-57 | 3 | 20,522 | Bob Buhl | Don Cardwell | Don Cardwell | Bob Buhl | | 600 | 524 | 76 |
| 1959-09-02 | vs PHI | 133 | L 5-11 | 66-58 | 3 | 18,047 | Lew Burdette | Robin Roberts | Robin Roberts | Lew Burdette | | 605 | 535 | 70 |
| 1959-09-04 | @ CIN | 134 | W 4-1 | 67-58 | 3 | 19,524 | Warren Spahn | Bob Purkey | Warren Spahn | Bob Purkey | | 609 | 536 | 73 |
| 1959-09-05 | @ CIN | 135 | L 1-5 | 67-59 | 3 | 7,359 | Bob Rush | Jay Hook | Jay Hook | Bob Rush | | 610 | 541 | 69 |
| 1959-09-06 | @ CIN | 136 | W 6-2 | 68-59 | 3 | 21,123 | Juan Pizarro | Jim O'Toole | Juan Pizarro | Jim O'Toole | | 616 | 543 | 73 |
| 1959-09-07 | vs PIT | 137 | W 5-1 | 70-59 | 2 | 0 | Lew Burdette | Bob Friend | Lew Burdette | Bob Friend | | 621 | 544 | 77 |
| 1959-09-07 | vs PIT | 138 | W 4-1 | 70-59 | 2 | 26,910 | Bob Buhl | Bennie Daniels | Bob Buhl | Bennie Daniels | | 625 | 545 | 80 |
| 1959-09-09 | vs SLN | 139 | W 5-3 | 71-59 | 2 | 19,888 | Warren Spahn | Ernie Broglio | Warren Spahn | Ernie Broglio | | 630 | 548 | 82 |
| 1959-09-10 | vs SLN | 140 | W 7-4 | 72-59 | 2 | 1,695 | Juan Pizarro | Larry Jackson | Don McMahon | Lindy McDaniel | | 637 | 552 | 85 |
| 1959-09-11 | vs CIN | 141 | W 10-2 | 73-59 | 3 | 25,817 | Joey Jay | Jay Hook | Joey Jay | Jay Hook | | 647 | 554 | 93 |
| 1959-09-12 | vs CIN | 142 | W 4-3 | 74-59 | 2 | 25,598 | Lew Burdette | Don Newcombe | Lew Burdette | Don Newcombe | | 651 | 557 | 94 |
| 1959-09-13 | vs CIN | 143 | L 2-3 | 74-60 | 2 | 35,084 | Warren Spahn | Bob Purkey | Bob Purkey | Warren Spahn | | 653 | 560 | 93 |
| 1959-09-14 | @ LAN | 144 | W 4-1 | 75-60 | 2 | 53,765 | Bob Buhl | Don Drysdale | Bob Buhl | Don Drysdale | Don McMahon | 657 | 561 | 96 |
| 1959-09-15 | @ LAN | 145 | L 7-8 | 75-61 | 2 | 17,347 | Joey Jay | Roger Craig | Chuck Churn | Don McMahon | | 664 | 569 | 95 |
| 1959-09-16 | @ SFN | 146 | W 2-0 | 76-61 | 2 | 22,721 | Lew Burdette | Sam Jones | Lew Burdette | Sam Jones | | 666 | 569 | 97 |
| 1959-09-17 | @ SFN | 147 | L 6-13 | 76-62 | 2 | 21,617 | Warren Spahn | Jack Sanford | Jack Sanford | Warren Spahn | Sam Jones | 672 | 582 | 90 |
| 1959-09-19 | @ PHI | 148 | W 9-3 | 77-62 | 3 | 17,216 | Bob Buhl | Don Cardwell | Bob Buhl | Don Cardwell | | 681 | 585 | 96 |
| 1959-09-20 | @ PHI | 149 | W 8-5 | 78-62 | 1 | 13,202 | Lew Burdette | Robin Roberts | Joey Jay | Robin Roberts | | 689 | 590 | 99 |
| 1959-09-21 | @ PIT | 150 | W 8-6 | 79-62 | 1 | 17,205 | Warren Spahn | Bob Friend | Warren Spahn | Bob Friend | Don McMahon | 697 | 596 | 101 |
| 1959-09-22 | @ PIT | 151 | W 5-3 | 79-62 | 1 | 17,658 | Juan Pizarro | Harvey Haddix | Juan Pizarro | Harvey Haddix | Don McMahon | 702 | 599 | 103 |
| 1959-09-23 | @ PIT | 152 | L 4-5 | 79-63 | 2 | 20,502 | Bob Buhl | Ron Kline | Ron Kline | Joey Jay | Roy Face | 706 | 604 | 102 |
| 1959-09-25 | vs PHI | 153 | L 3-6 | 79-64 | 2 | 24,912 | Lew Burdette | Don Cardwell | Jack Meyer | Lew Burdette | | 709 | 610 | 99 |
| 1959-09-26 | vs PHI | 154 | W 3-2 | 80-64 | 2 | 23,763 | Warren Spahn | Robin Roberts | Warren Spahn | Robin Roberts | | 712 | 612 | 100 |
| 1959-09-27 | vs PHI | 155 | W 5-2 | 81-64 | 1 | 48,642 | Bob Buhl | Jim Owens | Bob Buhl | Jim Owens | Don McMahon | 717 | 614 | 103 |
| 1959-09-28 | vs LAN | 156 | L 2-3 | 81-65 | 2 | 18,297 | Carl Willey | Danny McDevitt | Larry Sherry | Carl Willey | | 719 | 617 | 102 |
| 1959-09-29 | @ LAN | 157 | L 5-6 | 81-66 | 2 | 36,528 | Lew Burdette | Don Drysdale | Stan Williams | Bob Rush | | 724 | 623 | 101 |