| 1958-04-15 | vs WS1 | 1 | W 6-1 | 1-0 | 1 | 34,377 | Connie Johnson | Camilo Pascual | Billy O'Dell | Camilo Pascual | | 6 | 1 | 5 |
| 1958-04-17 | vs WS1 | 2 | W 4-0 | 2-0 | 1 | 19,377 | Milt Pappas | Chuck Stobbs | Jack Harshman | Chuck Stobbs | | 10 | 1 | 9 |
| 1958-04-18 | @ NYA | 3 | L 1-3 | 2-1 | 2 | 23,463 | Billy Loes | Whitey Ford | Whitey Ford | Billy Loes | | 11 | 4 | 7 |
| 1958-04-19 | @ NYA | 4 | L 3-4 | 2-2 | 3 | 18,387 | Billy O'Dell | Bobby Shantz | Bobby Shantz | Billy O'Dell | Ryne Duren | 14 | 8 | 6 |
| 1958-04-20 | @ NYA | 5 | L 0-7 | 2-3 | 6 | 21,597 | Connie Johnson | Bob Turley | Bob Turley | Connie Johnson | | 14 | 15 | -1 |
| 1958-04-22 | @ WS1 | 6 | W 4-2 | 3-3 | 4 | 1,839 | Jack Harshman | Ralph Lumenti | Jack Harshman | Ralph Lumenti | Billy O'Dell | 18 | 17 | 1 |
| 1958-04-23 | @ BOS | 7 | L 5-7 | 3-4 | 6 | 6,695 | Hal Brown | Tom Brewer | Tom Brewer | Charlie Beamon | Murray Wall | 23 | 24 | -1 |
| 1958-04-24 | @ BOS | 8 | L 3-4 | 3-5 | 6 | 6,690 | Milt Pappas | Mike Fornieles | Mike Fornieles | Billy O'Dell | | 26 | 28 | -2 |
| 1958-04-25 | vs NYA | 9 | W 2-1 | 4-5 | 6 | 20,363 | Connie Johnson | Whitey Ford | Connie Johnson | Whitey Ford | | 28 | 29 | -1 |
| 1958-04-26 | vs NYA | 10 | L 0-2 | 4-6 | 6 | 16,825 | Billy Loes | Bob Turley | Bob Turley | Billy Loes | | 28 | 31 | -3 |
| 1958-04-30 | vs CHA | 11 | W 3-2 | 5-6 | 6 | 10,759 | Jack Harshman | Early Wynn | Jack Harshman | Early Wynn | George Zuverink | 31 | 33 | -2 |
| 1958-05-01 | vs CHA | 12 | L 3-4 | 5-7 | 6 | 9,442 | Connie Johnson | Jim Wilson | Jim Wilson | Connie Johnson | Billy Pierce | 34 | 37 | -3 |
| 1958-05-02 | vs CLE | 13 | L 1-6 | 5-8 | 6 | 10,457 | Billy Loes | Mudcat Grant | Mudcat Grant | Billy Loes | | 35 | 43 | -8 |
| 1958-05-03 | vs CLE | 14 | W 3-2 | 6-8 | 6 | 2,262 | Billy O'Dell | Cal McLish | Billy O'Dell | Don Mossi | | 38 | 45 | -7 |
| 1958-05-04 | vs DET | 15 | W 4-3 | 8-8 | 4 | 0 | Milt Pappas | Paul Foytack | Milt Pappas | Paul Foytack | George Zuverink | 42 | 48 | -6 |
| 1958-05-04 | vs DET | 16 | W 4-0 | 8-8 | 4 | 22,746 | Jack Harshman | Billy Hoeft | Jack Harshman | Billy Hoeft | | 46 | 48 | -2 |
| 1958-05-09 | vs BOS | 17 | L 5-13 | 8-9 | 5 | 13,918 | Billy O'Dell | Dave Sisler | Dave Sisler | Billy O'Dell | | 51 | 61 | -10 |
| 1958-05-10 | vs BOS | 18 | W 5-2 | 9-9 | 3 | 8,311 | Jack Harshman | Tom Brewer | Jack Harshman | Tom Brewer | | 56 | 63 | -7 |
| 1958-05-11 | vs BOS | 19 | W 3-2 | 11-9 | 3 | 0 | Billy Loes | Frank Baumann | Billy O'Dell | Mike Fornieles | | 59 | 65 | -6 |
| 1958-05-11 | vs BOS | 20 | W 4-0 | 11-9 | 3 | 19,056 | Arnie Portocarrero | Willard Nixon | Arnie Portocarrero | Willard Nixon | George Zuverink | 63 | 65 | -2 |
| 1958-05-13 | @ NYA | 21 | L 0-3 | 11-10 | 3 | 13,606 | Connie Johnson | Don Larsen | Don Larsen | Connie Johnson | | 63 | 68 | -5 |
| 1958-05-14 | @ NYA | 22 | L 0-1 | 11-11 | 3 | 6,080 | Billy O'Dell | Bob Turley | Bob Turley | Billy O'Dell | | 63 | 69 | -6 |
| 1958-05-17 | @ BOS | 23 | L 4-7 | 12-12 | 3 | 10,610 | Jack Harshman | Tom Brewer | Murray Wall | Jack Harshman | Leo Kiely | 67 | 76 | -9 |
| 1958-05-17 | @ BOS | 24 | W 5-3 | 12-12 | 3 | 16,266 | Arnie Portocarrero | Frank Baumann | Arnie Portocarrero | Frank Baumann | George Zuverink | 72 | 79 | -7 |
| 1958-05-18 | @ BOS | 25 | L 4-8 | 12-13 | 5 | 17,933 | Billy Loes | Frank Sullivan | Frank Sullivan | Billy Loes | Leo Kiely | 76 | 87 | -11 |
| 1958-05-20 | @ DET | 26 | W 6-4 | 13-13 | 3 | 3,458 | Billy O'Dell | Billy Hoeft | Billy O'Dell | Billy Hoeft | Jack Harshman | 82 | 91 | -9 |
| 1958-05-21 | @ DET | 27 | W 8-1 | 14-13 | 2 | 3,387 | Connie Johnson | Frank Lary | Ken Lehman | Frank Lary | George Zuverink | 90 | 92 | -2 |
| 1958-05-22 | @ CHA | 28 | L 1-5 | 14-14 | 2 | 632 | Arnie Portocarrero | Jim Wilson | Jim Wilson | Arnie Portocarrero | | 91 | 97 | -6 |
| 1958-05-23 | @ CHA | 29 | L 0-1 | 14-15 | 4 | 10,192 | Jack Harshman | Early Wynn | Early Wynn | Jack Harshman | | 91 | 98 | -7 |
| 1958-05-24 | @ CHA | 30 | L 3-4 | 14-16 | 6 | 4,653 | Billy O'Dell | Bob Keegan | Bill Fischer | Billy O'Dell | | 94 | 102 | -8 |
| 1958-05-25 | @ KC1 | 31 | L 0-4 | 14-17 | 5 | 9,752 | Milt Pappas | Ned Garver | Ned Garver | Milt Pappas | | 94 | 106 | -12 |
| 1958-05-26 | @ KC1 | 32 | L 4-5 | 14-18 | 7 | 3,833 | Connie Johnson | Ralph Terry | Murry Dickson | Arnie Portocarrero | | 98 | 111 | -13 |
| 1958-05-27 | @ CLE | 33 | L 6-7 | 14-19 | 8 | 5,057 | Billy Loes | Mudcat Grant | Hoyt Wilhelm | Billy O'Dell | | 104 | 118 | -14 |
| 1958-05-28 | @ CLE | 34 | L 2-5 | 14-20 | 8 | 1,419 | Jack Harshman | Cal McLish | Cal McLish | Jack Harshman | | 106 | 123 | -17 |
| 1958-05-30 | vs BOS | 35 | L 0-2 | 15-21 | 8 | 0 | Connie Johnson | Frank Sullivan | Frank Sullivan | Connie Johnson | | 106 | 125 | -19 |
| 1958-05-30 | vs BOS | 36 | W 2-0 | 15-21 | 8 | 21,094 | Arnie Portocarrero | Bob Smith | Arnie Portocarrero | Bob Smith | | 108 | 125 | -17 |
| 1958-05-31 | vs WS1 | 37 | W 4-3 | 16-21 | 8 | 10,729 | Billy O'Dell | Al Cicotte | Billy O'Dell | Tex Clevenger | | 112 | 128 | -16 |
| 1958-06-01 | vs WS1 | 38 | L 2-5 | 16-22 | 8 | 7,684 | Billy Loes | Camilo Pascual | Camilo Pascual | Billy Loes | Dick Hyde | 114 | 133 | -19 |
| 1958-06-02 | vs WS1 | 39 | L 1-2 | 16-23 | 8 | 5,432 | Jack Harshman | Hal Griggs | Hal Griggs | Jack Harshman | | 115 | 135 | -20 |
| 1958-06-03 | vs DET | 40 | W 2-0 | 17-23 | 8 | 33,992 | Arnie Portocarrero | Jim Bunning | Arnie Portocarrero | Jim Bunning | | 117 | 135 | -18 |
| 1958-06-04 | vs DET | 41 | W 6-4 | 18-23 | 7 | 10,426 | Connie Johnson | Frank Lary | George Zuverink | Frank Lary | Jack Harshman | 123 | 139 | -16 |
| 1958-06-05 | vs DET | 42 | L 3-6 | 18-24 | 8 | 6,353 | Billy O'Dell | Paul Foytack | Hank Aguirre | Billy O'Dell | | 126 | 145 | -19 |
| 1958-06-06 | vs KC1 | 43 | W 2-1 | 20-24 | 8 | 0 | Connie Johnson | Alex Kellner | Connie Johnson | Alex Kellner | | 128 | 146 | -18 |
| 1958-06-06 | vs KC1 | 44 | W 3-1 | 20-24 | 8 | 12,561 | Milt Pappas | Ray Herbert | Milt Pappas | Ray Herbert | | 131 | 147 | -16 |
| 1958-06-07 | vs KC1 | 45 | L 2-5 | 20-25 | 8 | 6,904 | Jack Harshman | Murry Dickson | Murry Dickson | Jack Harshman | | 133 | 152 | -19 |
| 1958-06-08 | vs KC1 | 46 | W 4-0 | 21-26 | 6 | 0 | Hal Brown | Ned Garver | Hal Brown | Ned Garver | George Zuverink | 137 | 152 | -15 |
| 1958-06-08 | vs KC1 | 47 | L 1-2 | 21-26 | 6 | 12,344 | Arnie Portocarrero | Duke Maas | Duke Maas | Arnie Portocarrero | Virgil Trucks | 138 | 154 | -16 |
| 1958-06-09 | vs CLE | 48 | W 5-2 | 22-26 | 6 | 7,658 | Billy O'Dell | Cal McLish | Billy O'Dell | Cal McLish | | 143 | 156 | -13 |
| 1958-06-10 | vs CLE | 49 | L 2-10 | 22-27 | 6 | 9,229 | Connie Johnson | Gary Bell | Gary Bell | Connie Johnson | Hoyt Wilhelm | 145 | 166 | -21 |
| 1958-06-11 | vs CLE | 50 | W 7-4 | 23-27 | 6 | 7,516 | Milt Pappas | Dick Tomanek | Milt Pappas | Dick Tomanek | Hal Brown | 152 | 170 | -18 |
| 1958-06-12 | vs CLE | 51 | W 7-5 | 24-27 | 5 | 6,912 | Arnie Portocarrero | Mudcat Grant | Connie Johnson | Don Mossi | Billy O'Dell | 159 | 175 | -16 |
| 1958-06-13 | vs CHA | 52 | W 5-5 | 25-27 | 5 | 15,418 | Jack Harshman | Billy Pierce | | | | 164 | 180 | -16 |
| 1958-06-14 | vs CHA | 53 | L 1-9 | 25-28 | 6 | 8,022 | Billy Loes | Early Wynn | Early Wynn | Billy Loes | | 165 | 189 | -24 |
| 1958-06-15 | vs CHA | 54 | L 0-3 | 25-30 | 7 | 0 | Ken Lehman | Jim Wilson | Jim Wilson | Ken Lehman | | 165 | 192 | -27 |
| 1958-06-15 | vs CHA | 55 | L 0-4 | 25-30 | 7 | 14,607 | Arnie Portocarrero | Dick Donovan | Dick Donovan | Arnie Portocarrero | | 165 | 196 | -31 |
| 1958-06-17 | @ KC1 | 56 | W 4-1 | 26-30 | 6 | 24,047 | Billy O'Dell | Ray Herbert | Billy O'Dell | Ray Herbert | | 169 | 197 | -28 |
| 1958-06-18 | @ KC1 | 57 | W 5-3 | 27-30 | 6 | 10,843 | Milt Pappas | Murry Dickson | Milt Pappas | Murry Dickson | Arnie Portocarrero | 174 | 200 | -26 |
| 1958-06-19 | @ KC1 | 58 | W 4-2 | 28-30 | 4 | 8,736 | Hal Brown | Ned Garver | Ken Lehman | Ned Garver | Billy O'Dell | 178 | 202 | -24 |
| 1958-06-20 | @ CHA | 59 | L 3-5 | 28-31 | 5 | 15,116 | Jack Harshman | Dick Donovan | Bob Shaw | Jack Harshman | | 181 | 207 | -26 |
| 1958-06-21 | @ CHA | 60 | L 0-1 | 28-32 | 7 | 6,585 | Billy Loes | Billy Pierce | Billy Pierce | Billy Loes | | 181 | 208 | -27 |
| 1958-06-22 | @ CHA | 61 | W 2-0 | 29-32 | 5 | 12,114 | Billy O'Dell | Jim Wilson | Billy O'Dell | Jim Wilson | | 183 | 208 | -25 |
| 1958-06-23 | @ DET | 62 | L 1-3 | 29-33 | 7 | 3,615 | Arnie Portocarrero | George Susce | George Susce | Arnie Portocarrero | | 184 | 211 | -27 |
| 1958-06-24 | @ DET | 63 | L 0-5 | 29-34 | 7 | 20,022 | Milt Pappas | Paul Foytack | Paul Foytack | Milt Pappas | | 184 | 216 | -32 |
| 1958-06-26 | @ DET | 64 | W 2-0 | 30-34 | 5 | 7,194 | Jack Harshman | Billy Hoeft | Jack Harshman | Billy Hoeft | | 186 | 216 | -30 |
| 1958-06-27 | @ CLE | 65 | L 5-6 | 30-35 | 7 | 9,607 | Billy O'Dell | Ray Narleski | Don Mossi | Billy O'Dell | | 191 | 222 | -31 |
| 1958-06-28 | @ CLE | 66 | L 5-6 | 30-36 | 7 | 5,250 | Billy Loes | Mudcat Grant | Don Mossi | George Zuverink | | 196 | 228 | -32 |
| 1958-06-29 | @ CLE | 67 | W 11-6 | 32-36 | 6 | 0 | Milt Pappas | Gary Bell | Milt Pappas | Gary Bell | George Zuverink | 207 | 234 | -27 |
| 1958-06-29 | @ CLE | 68 | W 5-2 | 32-36 | 6 | 13,194 | Arnie Portocarrero | Jim Constable | Arnie Portocarrero | Jim Constable | | 212 | 236 | -24 |
| 1958-07-01 | vs NYA | 69 | W 7-5 | 33-37 | 6 | 0 | Hal Brown | Johnny Kucks | Billy Loes | Duke Maas | Connie Johnson | 219 | 241 | -22 |
| 1958-07-01 | vs NYA | 70 | L 1-2 | 33-37 | 6 | 33,292 | Jack Harshman | Don Larsen | Don Larsen | Jack Harshman | Ryne Duren | 220 | 243 | -23 |
| 1958-07-02 | vs NYA | 71 | L 1-4 | 33-38 | 7 | 11,695 | Billy O'Dell | Zach Monroe | Zach Monroe | Billy O'Dell | Ryne Duren | 221 | 247 | -26 |
| 1958-07-03 | @ BOS | 72 | W 7-5 | 34-38 | 6 | 3,921 | Charlie Beamon | Duane Wilson | Billy Loes | Murray Wall | | 228 | 252 | -24 |
| 1958-07-04 | @ BOS | 73 | L 1-5 | 35-39 | 5 | 0 | Milt Pappas | Frank Sullivan | Frank Sullivan | Connie Johnson | | 229 | 257 | -28 |
| 1958-07-04 | @ BOS | 74 | W 5-3 | 35-39 | 5 | 19,387 | Arnie Portocarrero | Mike Fornieles | Arnie Portocarrero | Mike Fornieles | | 234 | 260 | -26 |
| 1958-07-05 | @ WS1 | 75 | W 3-1 | 36-39 | 5 | 3,425 | Hal Brown | Hal Griggs | Hal Brown | Hal Griggs | Billy O'Dell | 237 | 261 | -24 |
| 1958-07-06 | @ WS1 | 76 | L 3-4 | 36-40 | 6 | 3,773 | Jack Harshman | Russ Kemmerer | Russ Kemmerer | Billy Loes | Dick Hyde | 240 | 265 | -25 |
| 1958-07-10 | vs KC1 | 77 | W 6-3 | 38-40 | 5 | 0 | Milt Pappas | Bud Daley | Milt Pappas | Bud Daley | Billy O'Dell | 246 | 268 | -22 |
| 1958-07-10 | vs KC1 | 78 | W 3-2 | 38-40 | 5 | 13,377 | Arnie Portocarrero | Ray Herbert | Arnie Portocarrero | Dick Tomanek | | 249 | 270 | -21 |
| 1958-07-13 | vs DET | 79 | L 5-6 | 38-42 | 6 | 0 | Charlie Beamon | Paul Foytack | Paul Foytack | Charlie Beamon | Bill Fischer | 254 | 276 | -22 |
| 1958-07-13 | vs DET | 80 | L 3-5 | 38-42 | 6 | 13,708 | Billy O'Dell | George Susce | George Susce | Billy O'Dell | Bill Fischer | 257 | 281 | -24 |
| 1958-07-14 | vs DET | 81 | W 2-1 | 39-42 | 5 | 2,742 | Hal Brown | Herb Moford | Hal Brown | Herb Moford | | 259 | 282 | -23 |
| 1958-07-15 | vs CHA | 82 | W 4-3 | 40-42 | 4 | 9,528 | Arnie Portocarrero | Jim Wilson | Arnie Portocarrero | Turk Lown | | 263 | 285 | -22 |
| 1958-07-16 | vs CHA | 83 | L 1-6 | 41-43 | 4 | 0 | Milt Pappas | Dick Donovan | Dick Donovan | Milt Pappas | | 264 | 291 | -27 |
| 1958-07-16 | vs CHA | 84 | W 6-5 | 41-43 | 4 | 16,565 | Jack Harshman | Bob Shaw | Jack Harshman | Bob Keegan | | 270 | 296 | -26 |
| 1958-07-17 | vs CHA | 85 | W 3-0 | 42-43 | 3 | 14,666 | Billy O'Dell | Billy Pierce | Billy O'Dell | Billy Pierce | | 273 | 296 | -23 |
| 1958-07-18 | vs CLE | 86 | L 1-5 | 42-44 | 3 | 8,820 | Charlie Beamon | Hal Woodeshick | Hal Woodeshick | Charlie Beamon | | 274 | 301 | -27 |
| 1958-07-19 | vs CLE | 87 | W 3-2 | 43-44 | 3 | 13,288 | Hal Brown | Gary Bell | Hal Brown | Gary Bell | Billy Loes | 277 | 303 | -26 |
| 1958-07-20 | vs CLE | 88 | W 3-2 | 44-44 | 3 | 11,342 | Arnie Portocarrero | Hoyt Wilhelm | Arnie Portocarrero | Hoyt Wilhelm | | 280 | 305 | -25 |
| 1958-07-22 | @ CHA | 89 | L 2-4 | 44-45 | 3 | 14,563 | Jack Harshman | Billy Pierce | Billy Pierce | Jack Harshman | Turk Lown | 282 | 309 | -27 |
| 1958-07-23 | @ CHA | 90 | W 6-4 | 45-45 | 3 | 5,501 | Billy O'Dell | Early Wynn | George Zuverink | Early Wynn | Arnie Portocarrero | 288 | 313 | -25 |
| 1958-07-24 | @ CHA | 91 | W 7-3 | 46-45 | 3 | 4,525 | Milt Pappas | Jim Wilson | Milt Pappas | Jim Wilson | | 295 | 316 | -21 |
| 1958-07-25 | @ KC1 | 92 | W 8-3 | 47-45 | 2 | 14,657 | Arnie Portocarrero | Bob Grim | Arnie Portocarrero | Bob Grim | | 303 | 319 | -16 |
| 1958-07-26 | @ KC1 | 93 | W 4-3 | 48-45 | 2 | 12,465 | Jack Harshman | Bob Davis | Jack Harshman | Bob Davis | Billy O'Dell | 307 | 322 | -15 |
| 1958-07-27 | @ KC1 | 94 | L 6-11 | 48-46 | 2 | 11,064 | Hal Brown | Ned Garver | Ned Garver | George Zuverink | Murry Dickson | 313 | 333 | -20 |
| 1958-07-29 | @ CLE | 95 | L 4-9 | 48-47 | 3 | 6,334 | Milt Pappas | Gary Bell | Gary Bell | Milt Pappas | | 317 | 342 | -25 |
| 1958-07-30 | @ CLE | 96 | L 3-6 | 48-48 | 2 | 6,003 | Arnie Portocarrero | Ray Narleski | Ray Narleski | Arnie Portocarrero | Mudcat Grant | 320 | 348 | -28 |
| 1958-08-01 | @ DET | 97 | L 1-3 | 48-49 | 2 | 18,312 | Jack Harshman | Herb Moford | Herb Moford | Jack Harshman | | 321 | 351 | -30 |
| 1958-08-02 | @ DET | 98 | L 7-8 | 48-50 | 3 | 7,566 | Billy O'Dell | Jim Bunning | Al Cicotte | Billy Loes | George Susce | 328 | 359 | -31 |
| 1958-08-03 | @ DET | 99 | L 2-3 | 48-52 | 6 | 0 | Milt Pappas | Paul Foytack | Paul Foytack | Milt Pappas | | 330 | 362 | -32 |
| 1958-08-03 | @ DET | 100 | L 1-4 | 48-52 | 6 | 17,229 | Hal Brown | Billy Hoeft | Billy Hoeft | Hal Brown | | 331 | 366 | -35 |
| 1958-08-04 | vs NYA | 101 | L 4-9 | 48-53 | 6 | 26,685 | Arnie Portocarrero | Don Larsen | Don Larsen | Arnie Portocarrero | Ryne Duren | 335 | 375 | -40 |
| 1958-08-05 | vs NYA | 102 | L 1-4 | 48-54 | 6 | 22,333 | Connie Johnson | Bob Turley | Bob Turley | Connie Johnson | | 336 | 379 | -43 |
| 1958-08-06 | vs NYA | 103 | L 1-3 | 48-55 | 6 | 18,076 | Jack Harshman | Art Ditmar | Art Ditmar | Jack Harshman | | 337 | 382 | -45 |
| 1958-08-08 | @ WS1 | 104 | L 2-4 | 48-56 | 6 | 5,375 | Hal Brown | Russ Kemmerer | Russ Kemmerer | Hal Brown | Dick Hyde | 339 | 386 | -47 |
| 1958-08-09 | @ WS1 | 105 | W 12-5 | 49-56 | 6 | 3,810 | Arnie Portocarrero | Camilo Pascual | Arnie Portocarrero | Camilo Pascual | Billy Loes | 351 | 391 | -40 |
| 1958-08-10 | @ WS1 | 106 | L 2-6 | 50-57 | 6 | 0 | Milt Pappas | Pedro Ramos | Pedro Ramos | Milt Pappas | Dick Hyde | 353 | 397 | -44 |
| 1958-08-10 | @ WS1 | 107 | W 6-1 | 50-57 | 6 | 7,198 | Billy O'Dell | Hal Griggs | Billy O'Dell | Hal Griggs | | 359 | 398 | -39 |
| 1958-08-11 | @ NYA | 108 | W 3-2 | 52-57 | 6 | 0 | Jack Harshman | Art Ditmar | Jack Harshman | Art Ditmar | | 362 | 400 | -38 |
| 1958-08-11 | @ NYA | 109 | W 9-3 | 52-57 | 6 | 14,572 | Connie Johnson | Johnny Kucks | Connie Johnson | Johnny Kucks | | 371 | 403 | -32 |
| 1958-08-12 | @ NYA | 110 | L 2-7 | 52-58 | 6 | 11,166 | Hal Brown | Tom Sturdivant | Tom Sturdivant | Hal Brown | Virgil Trucks | 373 | 410 | -37 |
| 1958-08-13 | vs BOS | 111 | W 2-1 | 53-58 | 6 | 24,101 | Arnie Portocarrero | Frank Sullivan | Arnie Portocarrero | Frank Sullivan | Billy O'Dell | 375 | 411 | -36 |
| 1958-08-15 | vs WS1 | 112 | L 1-3 | 53-59 | 6 | 7,375 | Jack Harshman | Vito Valentinetti | Vito Valentinetti | Jack Harshman | | 376 | 414 | -38 |
| 1958-08-16 | vs WS1 | 113 | W 9-0 | 54-59 | 6 | 7,767 | Billy O'Dell | Pedro Ramos | Billy O'Dell | Pedro Ramos | | 385 | 414 | -29 |
| 1958-08-17 | vs WS1 | 114 | W 2-1 | 55-59 | 5 | 6,588 | Connie Johnson | Russ Kemmerer | Connie Johnson | Russ Kemmerer | | 387 | 415 | -28 |
| 1958-08-18 | vs KC1 | 115 | W 8-2 | 56-59 | 4 | 4,741 | Hal Brown | Ralph Terry | Hal Brown | Ralph Terry | | 395 | 417 | -22 |
| 1958-08-19 | vs KC1 | 116 | L 1-4 | 56-61 | 6 | 0 | Milt Pappas | Ned Garver | Ned Garver | Milt Pappas | | 396 | 421 | -25 |
| 1958-08-19 | vs KC1 | 117 | L 4-6 | 56-61 | 6 | 11,334 | Arnie Portocarrero | Murry Dickson | Murry Dickson | Arnie Portocarrero | Tom Gorman | 400 | 427 | -27 |
| 1958-08-20 | vs KC1 | 118 | W 4-3 | 57-61 | 5 | 6,337 | Jack Harshman | Walt Craddock | Jack Harshman | Walt Craddock | | 404 | 430 | -26 |
| 1958-08-21 | vs DET | 119 | W 7-6 | 58-61 | 4 | 10,039 | Billy O'Dell | Billy Hoeft | Charlie Beamon | George Susce | Billy Loes | 411 | 436 | -25 |
| 1958-08-22 | vs DET | 120 | W 2-1 | 59-61 | 4 | 11,179 | Connie Johnson | Jim Bunning | Connie Johnson | Jim Bunning | Jack Harshman | 413 | 437 | -24 |
| 1958-08-23 | vs DET | 121 | L 1-5 | 59-62 | 4 | 9,172 | Arnie Portocarrero | Paul Foytack | Al Cicotte | Arnie Portocarrero | | 414 | 442 | -28 |
| 1958-08-24 | vs CHA | 122 | W 5-2 | 60-62 | 4 | 6,897 | Billy O'Dell | Dick Donovan | Billy O'Dell | Dick Donovan | Billy Loes | 419 | 444 | -25 |
| 1958-08-25 | vs CHA | 123 | W 6-5 | 61-62 | 4 | 7,741 | Jack Harshman | Ray Moore | Milt Pappas | Bob Shaw | Billy Loes | 425 | 449 | -24 |
| 1958-08-26 | vs CLE | 124 | W 1-0 | 62-62 | 4 | 9,637 | Hal Brown | Don Ferrarese | Hal Brown | Don Ferrarese | | 426 | 449 | -23 |
| 1958-08-27 | vs CLE | 125 | L 5-8 | 62-63 | 4 | 12,271 | Connie Johnson | Cal McLish | Cal McLish | Connie Johnson | Don Mossi | 431 | 457 | -26 |
| 1958-08-29 | @ BOS | 126 | L 2-5 | 62-64 | 4 | 16,411 | Arnie Portocarrero | Frank Sullivan | Frank Sullivan | Arnie Portocarrero | | 433 | 462 | -29 |
| 1958-08-30 | @ BOS | 127 | W 7-2 | 63-64 | 4 | 9,887 | Milt Pappas | Bill Monbouquette | Milt Pappas | Bill Monbouquette | Billy O'Dell | 440 | 464 | -24 |
| 1958-08-31 | @ BOS | 128 | L 2-3 | 63-65 | 4 | 13,112 | Hoyt Wilhelm | Tom Brewer | Tom Brewer | Hoyt Wilhelm | | 442 | 467 | -25 |
| 1958-09-01 | @ WS1 | 129 | W 2-0 | 65-65 | 4 | 0 | Jack Harshman | Camilo Pascual | Jack Harshman | Camilo Pascual | | 444 | 467 | -23 |
| 1958-09-01 | @ WS1 | 130 | W 10-1 | 65-65 | 4 | 9,485 | Billy O'Dell | Jim Constable | Billy O'Dell | Jim Constable | | 454 | 468 | -14 |
| 1958-09-02 | @ WS1 | 131 | L 3-4 | 65-66 | 4 | 2,233 | Hal Brown | Pedro Ramos | Pedro Ramos | Hal Brown | Dick Hyde | 457 | 472 | -15 |
| 1958-09-03 | @ WS1 | 132 | W 4-3 | 66-66 | 4 | 2,104 | Arnie Portocarrero | Vito Valentinetti | Arnie Portocarrero | Vito Valentinetti | Jack Harshman | 461 | 475 | -14 |
| 1958-09-04 | vs BOS | 133 | L 2-5 | 66-67 | 4 | 9,944 | Milt Pappas | Bill Monbouquette | Bill Monbouquette | Milt Pappas | Murray Wall | 463 | 480 | -17 |
| 1958-09-05 | vs BOS | 134 | L 2-10 | 66-68 | 5 | 12,682 | Jack Harshman | Tom Brewer | Tom Brewer | Jack Harshman | | 465 | 490 | -25 |
| 1958-09-06 | vs BOS | 135 | W 4-2 | 67-68 | 4 | 9,501 | Billy O'Dell | Ike Delock | Billy O'Dell | Ike Delock | | 469 | 492 | -23 |
| 1958-09-07 | vs BOS | 136 | L 5-6 | 67-69 | 4 | 9,416 | Hal Brown | Ted Bowsfield | Dave Sisler | Milt Pappas | Leo Kiely | 474 | 498 | -24 |
| 1958-09-09 | @ KC1 | 137 | L 6-8 | 67-70 | 5 | 7,545 | Arnie Portocarrero | Ralph Terry | Ralph Terry | Arnie Portocarrero | Tom Gorman | 480 | 506 | -26 |
| 1958-09-10 | @ KC1 | 138 | L 2-4 | 67-71 | 5 | 6,039 | Jack Harshman | Bob Grim | Bob Grim | Jack Harshman | | 482 | 510 | -28 |
| 1958-09-11 | @ KC1 | 139 | L 1-7 | 67-72 | 5 | 4,527 | Billy O'Dell | Ned Garver | Ned Garver | Billy O'Dell | | 483 | 517 | -34 |
| 1958-09-12 | @ DET | 140 | L 1-3 | 67-73 | 7 | 11,178 | Hoyt Wilhelm | Frank Lary | Frank Lary | Hoyt Wilhelm | | 484 | 520 | -36 |
| 1958-09-13 | @ DET | 141 | L 2-13 | 67-74 | 7 | 5,508 | Hal Brown | Jim Bunning | Jim Bunning | Hal Brown | | 486 | 533 | -47 |
| 1958-09-14 | @ CLE | 142 | L 4-7 | 68-75 | 6 | 0 | Connie Johnson | Don Ferrarese | Don Ferrarese | Connie Johnson | | 490 | 540 | -50 |
| 1958-09-14 | @ CLE | 143 | W 4-2 | 68-75 | 6 | 10,244 | Arnie Portocarrero | Mudcat Grant | Arnie Portocarrero | Mudcat Grant | Billy Loes | 494 | 542 | -48 |
| 1958-09-16 | @ CHA | 144 | L 3-4 | 68-76 | 6 | 5,241 | Billy O'Dell | Dick Donovan | Dick Donovan | Hoyt Wilhelm | | 497 | 546 | -49 |
| 1958-09-18 | @ CHA | 145 | L 2-6 | 68-77 | 7 | 734 | Jack Harshman | Ray Moore | Barry Latman | Jack Harshman | Turk Lown | 499 | 552 | -53 |
| 1958-09-19 | vs NYA | 146 | W 5-4 | 69-77 | 7 | 12,731 | Arnie Portocarrero | Whitey Ford | Lou Sleater | Art Ditmar | | 504 | 556 | -52 |
| 1958-09-20 | vs NYA | 147 | W 1-0 | 70-77 | 7 | 10,941 | Hoyt Wilhelm | Don Larsen | Hoyt Wilhelm | Bobby Shantz | | 505 | 556 | -51 |
| 1958-09-21 | vs NYA | 148 | W 3-2 | 71-77 | 6 | 4,177 | Milt Pappas | Tom Sturdivant | Milt Pappas | Tom Sturdivant | | 508 | 558 | -50 |
| 1958-09-22 | vs WS1 | 149 | W 2-0 | 72-77 | 6 | 5,701 | Hal Brown | Russ Kemmerer | Hal Brown | Russ Kemmerer | | 510 | 558 | -48 |
| 1958-09-23 | vs WS1 | 150 | W 3-2 | 73-77 | 6 | 6,478 | Jack Harshman | Pedro Ramos | Jack Harshman | Pedro Ramos | | 513 | 560 | -47 |
| 1958-09-24 | vs WS1 | 151 | W 2-0 | 74-77 | 6 | 8,124 | Arnie Portocarrero | Camilo Pascual | Arnie Portocarrero | Camilo Pascual | | 515 | 560 | -45 |
| 1958-09-26 | @ NYA | 152 | W 3-2 | 75-77 | 6 | 14,668 | Hoyt Wilhelm | Whitey Ford | Billy Loes | Virgil Trucks | | 518 | 562 | -44 |
| 1958-09-28 | @ NYA | 153 | L 0-7 | 75-79 | 6 | 0 | Jack Harshman | Don Larsen | Don Larsen | Jack Harshman | Johnny Kucks | 518 | 569 | -51 |
| 1958-09-28 | @ NYA | 154 | L 3-6 | 75-79 | 6 | 17,763 | Milt Pappas | Tom Sturdivant | Tom Sturdivant | Milt Pappas | Zach Monroe | 521 | 575 | -54 |