| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2016-04-03 | Sun | TOR | AL | H | D | 1 | L | 3-5 | 9 | box - pbp - pit | L1 | 0-1 | 2 | 3 | 5 | 2:51 | 31,042 | Chris Archer | Marcus Stroman (R) | Marcus Stroman | Chris Archer | Roberto Osuna | |
| 2016-04-04 | Mon | TOR | AL | H | N | 2 | L | 3-5 | 9 | box - pbp - pit | L2 | 0-2 | 3 | 7 | 14 | 2:58 | 15,116 | Drew Smyly | R.A. Dickey (R) | R.A. Dickey | Drew Smyly | Roberto Osuna | |
| 2016-04-05 | Tue | TOR | AL | H | N | 3 | W | 3-2 | 9 | box - pbp - pit | W1 | 1-2 | 4 | 10 | 19 | 3:07 | 12,757 | Jake Odorizzi | Aaron Sanchez (R) | Alex Colome | Brett Cecil | None | |
| 2016-04-06 | Wed | TOR | AL | H | D | 4 | W | 5-3 | 9 | box - pbp - pit | W2 | 2-2 | 4 | 6 | 15 | 2:47 | 14,257 | Matt Moore | J.A. Happ (L) | Erasmo Ramirez | Gavin Floyd | None | |
| 2016-04-08 | Fri | BAL | AL | A | N | 5 | L | 1-6 | 9 | box - pbp - pit | L1 | 2-3 | 4 | 10 | 20 | 2:46 | 17,304 | Chris Archer | Chris Tillman (R) | Chris Tillman | Chris Archer | None | |
| 2016-04-10 | Sun | BAL | AL | A | D | 6 | L | 3-5 | 9 | box - pbp - pit | L2 | 2-4 | 5 | 11 | 22 | 2:53 | 23,101 | Jake Odorizzi | Vance Worley (R) | Brad Brach | Jake Odorizzi | Zach Britton | |
| 2016-04-12 | Tue | CLE | AL | H | N | 7 | W | 5-1 | 9 | box - pbp - pit | W1 | 3-4 | 4 | 9 | 20 | 2:34 | 10,283 | Matt Moore | Corey Kluber (R) | Xavier Cedeno | Corey Kluber | None | |
| 2016-04-13 | Wed | CLE | AL | H | N | 8 | L | 1-4 | 9 | box - pbp - pit | L1 | 3-5 | 5 | 12 | 23 | 2:32 | 10,117 | Drew Smyly | Carlos Carrasco (R) | Carlos Carrasco | Drew Smyly | Cody Allen | |
| 2016-04-14 | Thu | CLE | AL | H | D | 9 | L | 0-6 | 9 | box - pbp - pit | L2 | 3-6 | 5 | 12 | 24 | 3:20 | 10,715 | Chris Archer | Danny Salazar (R) | Danny Salazar | Chris Archer | None | |
| 2016-04-15 | Fri | CHA | AL | H | N | 10 | L | 0-1 | 9 | box - pbp - pit | L3 | 3-7 | 5 | 14 | 27 | 2:23 | 16,801 | Jake Odorizzi | Chris Sale (L) | Chris Sale | Alex Colome | None | |
| 2016-04-16 | Sat | CHA | AL | H | N | 11 | W | 7-2 | 9 | box - pbp - pit | W1 | 4-7 | 5 | 13 | 24 | 2:52 | 30,451 | Erasmo Ramirez | John Danks (L) | Erasmo Ramirez | John Danks | None | |
| 2016-04-17 | Sun | CHA | AL | H | D | 12 | W | 3-2 | 9 | box - pbp - pit | W2 | 5-7 | 5 | 11 | 21 | 2:36 | 21,810 | Matt Moore | Jose Quintana (L) | Matt Moore | Jose Quintana | Alex Colome | |
| 2016-04-19 | Tue | BOS | AL | A | N | 13 | W | 3-0 | 10 | box - pbp - pit | W3 | 6-7 | 4 | 9 | 19 | 3:25 | 32,061 | Drew Smyly | Joe Kelly (R) | Erasmo Ramirez | Matt Barnes | Alex Colome | |
| 2016-04-20 | Wed | BOS | AL | A | N | 14 | L | 3-7 | 9 | box - pbp - pit | L1 | 6-8 | 4 | 11 | 22 | 3:02 | 31,689 | Chris Archer | Rick Porcello (R) | Rick Porcello | Chris Archer | None | |
| 2016-04-21 | Thu | BOS | AL | A | D | 15 | W | 12-8 | 9 | box - pbp - pit | W1 | 7-8 | 4 | 9 | 18 | 4:16 | 37,954 | Jake Odorizzi | David Price (L) | Erasmo Ramirez | William Cuevas | Alex Colome | |
| 2016-04-22 | Fri | NYA | AL | A | N | 16 | L | 3-6 | 9 | box - pbp - pit | L1 | 7-9 | 4 | 11 | 22 | 3:02 | 31,843 | Matt Moore | CC Sabathia (L) | Ivan Nova | Matt Moore | Andrew Miller | |
| 2016-04-23 | Sat | NYA | AL | A | D | 17 | L | 2-3 | 9 | box - pbp - pit | L2 | 7-10 | 5 | 13 | 24 | 2:55 | 40,714 | Blake Snell | Masahiro Tanaka (R) | Andrew Miller | Erasmo Ramirez | None | |
| 2016-04-24 | Sun | NYA | AL | A | D | 18 | W | 8-1 | 9 | box - pbp - pit | W1 | 8-10 | 4 | 11 | 22 | 2:50 | 40,981 | Drew Smyly | Michael Pineda (R) | Drew Smyly | Michael Pineda | None | |
| 2016-04-25 | Mon | BAL | AL | H | N | 19 | W | 2-0 | 9 | box - pbp - pit | W2 | 9-10 | 4 | 11 | 19 | 2:37 | 12,996 | Chris Archer | Kevin Gausman (R) | Chris Archer | Kevin Gausman | Alex Colome | |
| 2016-04-26 | Tue | BAL | AL | H | N | 20 | W | 3-1 | 9 | box - pbp - pit | W3 | 10-10 | 3 | 9 | 17 | 2:44 | 10,988 | Jake Odorizzi | Ubaldo Jimenez (R) | Enny Romero | Ubaldo Jimenez | Alex Colome | |
| 2016-04-27 | Wed | BAL | AL | H | N | 21 | L | 1-3 | 9 | box - pbp - pit | L1 | 10-11 | 3 | 11 | 20 | 2:43 | 11,850 | Matt Moore | Chris Tillman (R) | Chris Tillman | Matt Moore | Zach Britton | |
| 2016-04-29 | Fri | TOR | AL | H | N | 22 | L | 1-6 | 9 | box - pbp - pit | L2 | 10-12 | 4 | 12 | 23 | 2:43 | 13,679 | Drew Smyly | Aaron Sanchez (R) | Aaron Sanchez | Drew Smyly | None | |
| 2016-04-30 | Sat | TOR | AL | H | N | 23 | W | 4-3 | 9 | box - pbp - pit | W1 | 11-12 | 3 | 9 | 18 | 2:52 | 14,948 | Chris Archer | J.A. Happ (L) | Xavier Cedeno | Brett Cecil | None | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2016-05-01 | Sun | TOR | AL | H | D | 24 | L | 1-5 | 9 | box - pbp - pit | L1 | 11-13 | 4 | 11 | 21 | 2:34 | 27,217 | Jake Odorizzi | Marcus Stroman (R) | Marcus Stroman | Xavier Cedeno | None | |
| 2016-05-03 | Tue | LAN | NL | H | N | 25 | L | 5-10 | 9 | box - pbp - pit | L2 | 11-14 | 4 | 12 | 22 | 3:11 | 14,116 | Matt Moore | Scott Kazmir (L) | Scott Kazmir | Matt Moore | Kenley Jansen | |
| 2016-05-04 | Wed | LAN | NL | H | N | 26 | W | 8-5 | 9 | box - pbp - pit | W1 | 12-14 | 4 | 11 | 21 | 3:21 | 13,226 | Drew Smyly | Alex Wood (L) | Erasmo Ramirez | Alex Wood | Alex Colome | |
| 2016-05-06 | Fri | ANA | AL | A | N | 27 | W | 5-2 | 9 | box - pbp - pit | W2 | 13-14 | 4 | 10 | 20 | 3:06 | 41,253 | Chris Archer | Cory Rasmus (R) | Chris Archer | Cory Rasmus | Alex Colome | |
| 2016-05-07 | Sat | ANA | AL | A | N | 28 | W | 4-2 | 9 | box - pbp - pit | W3 | 14-14 | 3 | 8 | 17 | 3:06 | 40,142 | Jake Odorizzi | Jered Weaver (R) | Erasmo Ramirez | Joe Smith | Alex Colome | |
| 2016-05-08 | Sun | ANA | AL | A | D | 29 | W | 3-1 | 9 | box - pbp - pit | W4 | 15-14 | 3 | 7 | 13 | 2:56 | 41,086 | Matt Andriese | Nick Tropeano (R) | Matt Andriese | Nick Tropeano | Alex Colome | |
| 2016-05-09 | Mon | SEA | AL | A | N | 30 | L | 2-5 | 9 | box - pbp - pit | L1 | 15-15 | 3 | 8 | 14 | 3:05 | 15,230 | Matt Moore | Felix Hernandez (R) | Felix Hernandez | Dana Eveland | Steve Cishek | |
| 2016-05-10 | Tue | SEA | AL | A | N | 31 | L | 4-6 | 9 | box - pbp - pit | L2 | 15-16 | 4 | 8 | 18 | 2:46 | 16,013 | Drew Smyly | Wade Miley (L) | Wade Miley | Drew Smyly | Steve Cishek | |
| 2016-05-11 | Wed | SEA | AL | A | D | 32 | L | 5-6 | 11 | box - pbp - pit | L3 | 15-17 | 4 | 9 | 20 | 4:01 | 23,000 | Chris Archer | Taijuan Walker (R) | Steve Johnson | Steve Geltz | None | |
| 2016-05-13 | Fri | OAK | AL | H | N | 33 | L | 3-6 | 9 | box - pbp - pit | L4 | 15-18 | 4 | 9 | 19 | 3:07 | 14,604 | Jake Odorizzi | Rich Hill (L) | Rich Hill | Jake Odorizzi | Ryan Madson | |
| 2016-05-14 | Sat | OAK | AL | H | N | 34 | W | 6-0 | 9 | box - pbp - pit | W1 | 16-18 | 4 | 9 | 19 | 2:36 | 28,158 | Matt Andriese | Kendall Graveman (R) | Matt Andriese | Kendall Graveman | None | |
| 2016-05-15 | Sun | OAK | AL | H | D | 35 | L | 6-7 | 9 | box - pbp - pit | L1 | 16-19 | 4 | 9 | 19 | 3:05 | 19,545 | Matt Moore | Sonny Gray (R) | John Axford | Steve Geltz | Ryan Madson | |
| 2016-05-16 | Mon | TOR | AL | A | N | 36 | W | 13-2 | 9 | box - pbp - pit | W1 | 17-19 | 4 | 9 | 19 | 2:54 | 26,516 | Drew Smyly | J.A. Happ (L) | Drew Smyly | J.A. Happ | None | |
| 2016-05-17 | Tue | TOR | AL | A | N | 37 | W | 12-2 | 9 | box - pbp - pit | W2 | 18-19 | 3 | 8 | 18 | 2:43 | 27,321 | Chris Archer | Marcus Stroman (R) | Chris Archer | Marcus Stroman | None | |
| 2016-05-18 | Wed | TOR | AL | A | N | 38 | W | 6-3 | 9 | box - pbp - pit | W3 | 19-19 | 3 | 8 | 18 | 2:48 | 29,078 | Jake Odorizzi | R.A. Dickey (R) | Jake Odorizzi | R.A. Dickey | Alex Colome | |
| 2016-05-20 | Fri | DET | AL | A | N | 39 | W | 7-5 | 9 | box - pbp - pit | W4 | 20-19 | 3 | 7 | 14 | 3:26 | 30,304 | Matt Andriese | Anibal Sanchez (R) | Matt Andriese | Anibal Sanchez | Alex Colome | |
| 2016-05-21 | Sat | DET | AL | A | D | 40 | L | 4-5 | 9 | box - pbp - pit | L1 | 20-20 | 3 | 8 | 17 | 2:58 | 32,316 | Drew Smyly | Michael Fulmer (R) | Michael Fulmer | Drew Smyly | Francisco Rodriguez | |
| 2016-05-22 | Sun | DET | AL | A | D | 41 | L | 4-9 | 9 | box - pbp - pit | L2 | 20-21 | 4 | 10 | 20 | 3:03 | 34,758 | Chris Archer | Jordan Zimmermann (R) | Jordan Zimmermann | Chris Archer | None | |
| 2016-05-23 | Mon | MIA | NL | A | N | 42 | L | 6-7 | 9 | box - pbp - pit | L3 | 20-22 | 5 | 11 | 21 | 3:11 | 17,969 | Matt Moore | Wei-Yin Chen (L) | David Phelps | Erasmo Ramirez | A.J. Ramos | |
| 2016-05-24 | Tue | MIA | NL | A | D | 43 | W | 4-3 | 9 | box - pbp - pit | W1 | 21-22 | 4 | 10 | 19 | 3:21 | 23,709 | Jake Odorizzi | Tom Koehler (R) | Jake Odorizzi | Tom Koehler | Alex Colome | |
| 2016-05-25 | Wed | MIA | NL | H | N | 44 | L | 3-4 | 9 | box - pbp - pit | L1 | 21-23 | 5 | 11 | 20 | 3:22 | 13,554 | Matt Andriese | Justin Nicolino (L) | Kyle Barraclough | Tyler Sturdevant | A.J. Ramos | |
| 2016-05-26 | Thu | MIA | NL | H | D | 45 | L | 1-9 | 9 | box - pbp - pit | L2 | 21-24 | 5 | 11 | 21 | 2:51 | 11,399 | Drew Smyly | Jose Fernandez (R) | Jose Fernandez | Drew Smyly | None | |
| 2016-05-27 | Fri | NYA | AL | H | N | 46 | L | 1-4 | 9 | box - pbp - pit | L3 | 21-25 | 5 | 12 | 23 | 2:36 | 14,697 | Chris Archer | Masahiro Tanaka (R) | Masahiro Tanaka | Chris Archer | None | |
| 2016-05-28 | Sat | NYA | AL | H | D | 47 | W | 9-5 | 9 | box - pbp - pit | W1 | 22-25 | 5 | 11 | 21 | 3:15 | 20,188 | Matt Moore | Michael Pineda (R) | Matt Moore | Michael Pineda | None | |
| 2016-05-29 | Sun | NYA | AL | H | D | 48 | L | 1-2 | 9 | box - pbp - pit | L1 | 22-26 | 5 | 11 | 22 | 2:45 | 19,748 | Jake Odorizzi | Nathan Eovaldi (R) | Nathan Eovaldi | Jake Odorizzi | Aroldis Chapman | |
| 2016-05-30 | Mon | KCA | AL | A | N | 49 | L | 2-6 | 9 | box - pbp - pit | L2 | 22-27 | 5 | 12 | 23 | 3:03 | 32,018 | Matt Andriese | Ian Kennedy (R) | Kelvin Herrera | Erasmo Ramirez | None | |
| 2016-05-31 | Tue | KCA | AL | A | N | 50 | L | 5-10 | 9 | box - pbp - pit | L3 | 22-28 | 5 | 14 | 25 | 3:27 | 26,006 | Drew Smyly | Dillon Gee (R) | Dillon Gee | Drew Smyly | Wade Davis | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2016-06-01 | Wed | KCA | AL | A | N | 51 | L | 3-6 | 9 | box - pbp - pit | L4 | 22-29 | 5 | 14 | 25 | 2:45 | 30,554 | Chris Archer | Danny Duffy (L) | Danny Duffy | Chris Archer | Wade Davis | |
| 2016-06-02 | Thu | MIN | AL | A | N | 52 | L | 4-6 | 9 | box - pbp - pit | L5 | 22-30 | 5 | 14 | 26 | 2:44 | 20,193 | Matt Moore | Phil Hughes (R) | Taylor Rogers | Erasmo Ramirez | Kevin Jepsen | |
| 2016-06-03 | Fri | MIN | AL | A | N | 53 | W | 4-2 | 9 | box - pbp - pit | W1 | 23-30 | 5 | 14 | 25 | 3:03 | 21,134 | Jake Odorizzi | Ricky Nolasco (R) | Erasmo Ramirez | Ricky Nolasco | Alex Colome | |
| 2016-06-04 | Sat | MIN | AL | A | D | 54 | W | 7-4 | 9 | box - pbp - pit | W2 | 24-30 | 5 | 14 | 24 | 3:10 | 26,613 | Matt Andriese | Ervin Santana (R) | Matt Andriese | Ervin Santana | Alex Colome | |
| 2016-06-05 | Sun | MIN | AL | A | D | 55 | W | 7-5 | 9 | box - pbp - pit | W3 | 25-30 | 5 | 13 | 23 | 3:19 | 25,510 | Drew Smyly | Tyler Duffey (R) | Xavier Cedeno | Kevin Jepsen | Alex Colome | |
| 2016-06-06 | Mon | ARI | NL | A | N | 56 | W | 6-4 | 9 | box - pbp - pit | W4 | 26-30 | 5 | 12 | 21 | 3:30 | 17,176 | Chris Archer | Robbie Ray (L) | Chris Archer | Robbie Ray | Alex Colome | |
| 2016-06-07 | Tue | ARI | NL | A | N | 57 | L | 0-5 | 9 | box - pbp - pit | L1 | 26-31 | 5 | 12 | 22 | 2:15 | 17,964 | Matt Moore | Zack Greinke (R) | Zack Greinke | Matt Moore | None | |
| 2016-06-08 | Wed | ARI | NL | A | D | 58 | W | 6-3 | 9 | box - pbp - pit | W1 | 27-31 | 5 | 12 | 22 | 3:00 | 16,954 | Jake Odorizzi | Archie Bradley (R) | Jake Odorizzi | Archie Bradley | Alex Colome | |
| 2016-06-10 | Fri | HOU | AL | H | N | 59 | W | 4-3 | 9 | box - pbp - pit | W2 | 28-31 | 5 | 11 | 20 | 3:19 | 13,075 | Matt Andriese | Lance McCullers (R) | Matt Andriese | Lance McCullers | Alex Colome | |
| 2016-06-11 | Sat | HOU | AL | H | D | 60 | L | 3-4 | 9 | box - pbp - pit | L1 | 28-32 | 5 | 12 | 23 | 2:52 | 19,658 | Chris Archer | Mike Fiers (R) | Michael Fiers | Chris Archer | Will Harris | |
| 2016-06-12 | Sun | HOU | AL | H | D | 61 | W | 5-0 | 9 | box - pbp - pit | W1 | 29-32 | 5 | 11 | 21 | 2:45 | 11,168 | Matt Moore | Dallas Keuchel (L) | Matt Moore | Dallas Keuchel | None | |
| 2016-06-14 | Tue | SEA | AL | H | N | 62 | W | 8-7 | 9 | box - pbp - pit | W2 | 30-32 | 5 | 11 | 20 | 3:12 | 11,455 | Jake Odorizzi | Taijuan Walker (R) | Ryan Garton | Mike Montgomery | Alex Colome | |
| 2016-06-15 | Wed | SEA | AL | H | N | 63 | W | 3-2 | 13 | box - pbp - pit | W3 | 31-32 | 4 | 10 | 19 | 4:38 | 12,239 | Drew Smyly | Nate Karns (R) | Matt Andriese | Mike Montgomery | None | |
| 2016-06-16 | Thu | SEA | AL | H | D | 64 | L | 4-6 | 9 | box - pbp - pit | L1 | 31-33 | 5 | 11 | 20 | 3:30 | 11,331 | Blake Snell | James Paxton (L) | James Paxton | Blake Snell | Steve Cishek | |
| 2016-06-17 | Fri | SFN | NL | H | N | 65 | L | 1-5 | 9 | box - pbp - pit | L2 | 31-34 | 5 | 11 | 20 | 2:45 | 40,135 | Chris Archer | Jeff Samardzija (R) | Jeff Samardzija | Chris Archer | None | |
| 2016-06-18 | Sat | SFN | NL | H | D | 66 | L | 4-6 | 9 | box - pbp - pit | L3 | 31-35 | 5 | 12 | 21 | 3:13 | 23,948 | Matt Moore | Albert Suarez (R) | Hunter Strickland | Alex Colome | Cory Gearrin | |
| 2016-06-19 | Sun | SFN | NL | H | D | 67 | L | 1-5 | 9 | box - pbp - pit | L4 | 31-36 | 5 | 12 | 21 | 3:30 | 17,361 | Jake Odorizzi | Jake Peavy (R) | Derek Law | Xavier Cedeno | None | |
| 2016-06-20 | Mon | CLE | AL | A | N | 68 | L | 4-7 | 9 | box - pbp - pit | L5 | 31-37 | 5 | 12 | 22 | 2:26 | 13,811 | Drew Smyly | Josh Tomlin (R) | Bryan Shaw | Erasmo Ramirez | Cody Allen | |
| 2016-06-21 | Tue | CLE | AL | A | N | 69 | L | 0-6 | 9 | box - pbp - pit | L6 | 31-38 | 5 | 12 | 22 | 2:36 | 15,629 | Blake Snell | Corey Kluber (R) | Corey Kluber | Blake Snell | None | |
| 2016-06-22 | Wed | CLE | AL | A | N | 70 | L | 1-6 | 9 | box - pbp - pit | L7 | 31-39 | 5 | 12 | 23 | 2:30 | 21,216 | Chris Archer | Trevor Bauer (R) | Trevor Bauer | Chris Archer | None | |
| 2016-06-24 | Fri | BAL | AL | A | N | 71 | L | 3-6 | 9 | box - pbp - pit | L8 | 31-40 | 5 | 12 | 23 | 3:07 | 44,956 | Matt Moore | Yovani Gallardo (R) | Ashur Tolliver | Matt Moore | Zach Britton | |
| 2016-06-25 | Sat | BAL | AL | A | D | 72 | L | 0-5 | 9 | box - pbp - pit | L9 | 31-42 | 5 | 13 | 25 | 2:46 | 18,229 | Matt Andriese | Kevin Gausman (R) | Kevin Gausman | Matt Andriese | None | |
| 2016-06-25 | Sat | BAL | AL | A | N | 73 | L | 6-8 | 9 | box - pbp - pit | L10 | 31-42 | 5 | 13 | 25 | 3:15 | 33,040 | Jake Odorizzi | Chris Tillman (R) | T.J. McFarland | Erasmo Ramirez | Zach Britton | |
| 2016-06-26 | Sun | BAL | AL | A | D | 74 | L | 5-12 | 9 | box - pbp - pit | L11 | 31-43 | 5 | 14 | 26 | 3:03 | 38,611 | Drew Smyly | Tyler Wilson (R) | Tyler Wilson | Drew Smyly | None | |
| 2016-06-27 | Mon | BOS | AL | H | N | 75 | W | 13-7 | 9 | box - pbp - pit | W1 | 32-43 | 5 | 13 | 25 | 3:29 | 18,024 | Blake Snell | Eduardo Rodriguez (L) | Blake Snell | Eduardo Rodriguez | None | |
| 2016-06-28 | Tue | BOS | AL | H | N | 76 | L | 2-8 | 9 | box - pbp - pit | L1 | 32-44 | 5 | 13 | 26 | 3:11 | 16,986 | Chris Archer | Rick Porcello (R) | Rick Porcello | Chris Archer | None | |
| 2016-06-29 | Wed | BOS | AL | H | D | 77 | W | 4-0 | 9 | box - pbp - pit | W1 | 33-44 | 5 | 13 | 25 | 2:49 | 24,110 | Matt Moore | David Price (L) | Matt Moore | David Price | None | |
| 2016-06-30 | Thu | DET | AL | H | N | 78 | L | 7-10 | 9 | box - pbp - pit | L1 | 33-45 | 5 | 13 | 25 | 3:25 | 10,729 | Jake Odorizzi | Jordan Zimmermann (R) | Anibal Sanchez | Erasmo Ramirez | Francisco Rodriguez | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2016-07-01 | Fri | DET | AL | H | N | 79 | L | 2-10 | 9 | box - pbp - pit | L2 | 33-46 | 5 | 13 | 26 | 3:06 | 13,537 | Drew Smyly | Michael Fulmer (R) | Michael Fulmer | Drew Smyly | None | |
| 2016-07-02 | Sat | DET | AL | H | D | 80 | L | 2-3 | 9 | box - pbp - pit | L3 | 33-47 | 5 | 13 | 26 | 2:53 | 17,861 | Blake Snell | Justin Verlander (R) | Justin Verlander | Blake Snell | Francisco Rodriguez | |
| 2016-07-03 | Sun | DET | AL | H | D | 81 | L | 1-5 | 9 | box - pbp - pit | L4 | 33-48 | 5 | 13 | 26 | 3:11 | 13,126 | Chris Archer | Mike Pelfrey (R) | Bruce Rondon | Matt Andriese | None | |
| 2016-07-04 | Mon | ANA | AL | H | D | 82 | W | 4-2 | 9 | box - pbp - pit | W1 | 34-48 | 5 | 13 | 26 | 3:12 | 14,532 | Matt Moore | Nick Tropeano (R) | Matt Moore | Fernando Salas | Ryan Garton | |
| 2016-07-05 | Tue | ANA | AL | H | N | 83 | L | 5-13 | 9 | box - pbp - pit | L1 | 34-49 | 5 | 13 | 26 | 3:19 | 14,896 | Jake Odorizzi | Tim Lincecum (R) | Deolis Guerra | Jake Odorizzi | None | |
| 2016-07-06 | Wed | ANA | AL | H | N | 84 | L | 2-7 | 9 | box - pbp - pit | L2 | 34-50 | 5 | 14 | 27 | 3:18 | 11,267 | Drew Smyly | Jered Weaver (R) | Jered Weaver | Drew Smyly | None | |
| 2016-07-07 | Thu | ANA | AL | H | D | 85 | L | 1-5 | 9 | box - pbp - pit | L3 | 34-51 | 5 | 14 | 27 | 3:01 | 14,576 | Blake Snell | Hector Santiago (L) | Hector Santiago | Blake Snell | None | |
| 2016-07-08 | Fri | BOS | AL | A | N | 86 | L | 5-6 | 9 | box - pbp - pit | L4 | 34-52 | 5 | 14 | 27 | 3:20 | 37,739 | Chris Archer | Sean O'Sullivan (R) | Robbie Ross | Chris Archer | Koji Uehara | |
| 2016-07-09 | Sat | BOS | AL | A | D | 87 | L | 1-4 | 9 | box - pbp - pit | L5 | 34-53 | 5 | 14 | 27 | 2:43 | 36,900 | Matt Moore | Rick Porcello (R) | Rick Porcello | Matt Moore | Koji Uehara | |
| 2016-07-10 | Sun | BOS | AL | A | D | 88 | L | 0-4 | 9 | box - pbp - pit | L6 | 34-54 | 5 | 14 | 27 | 2:31 | 36,669 | Jake Odorizzi | David Price (L) | David Price | Jake Odorizzi | None | |
| 2016-07-15 | Fri | BAL | AL | H | N | 89 | L | 3-4 | 9 | box - pbp - pit | L7 | 34-55 | 5 | 14 | 27 | 3:00 | 17,672 | Chris Archer | Yovani Gallardo (R) | Mychal Givens | Chris Archer | Zach Britton | |
| 2016-07-16 | Sat | BAL | AL | H | N | 90 | L | 1-2 | 9 | box - pbp - pit | L8 | 34-56 | 5 | 14 | 27 | 2:33 | 18,638 | Matt Moore | Chris Tillman (R) | Chris Tillman | Matt Moore | Zach Britton | |
| 2016-07-17 | Sun | BAL | AL | H | D | 91 | W | 5-2 | 9 | box - pbp - pit | W1 | 35-56 | 5 | 14 | 27 | 2:32 | 16,161 | Jake Odorizzi | Dylan Bundy (R) | Jake Odorizzi | Dylan Bundy | Alex Colome | |
| 2016-07-18 | Mon | COL | NL | A | N | 92 | L | 4-7 | 9 | box - pbp - pit | L1 | 35-57 | 5 | 14 | 27 | 3:12 | 30,601 | Drew Smyly | Tyler Anderson (L) | Tyler Anderson | Drew Smyly | Carlos Estevez | |
| 2016-07-19 | Tue | COL | NL | A | N | 93 | W | 10-1 | 9 | box - pbp - pit | W1 | 36-57 | 5 | 14 | 27 | 2:54 | 33,061 | Blake Snell | Tyler Chatwood (R) | Blake Snell | Tyler Chatwood | Matt Andriese | |
| 2016-07-20 | Wed | COL | NL | A | D | 94 | W | 11-3 | 9 | box - pbp - pit | W2 | 37-57 | 5 | 14 | 27 | 3:27 | 31,456 | Chris Archer | Jorge De La Rosa (L) | Chris Archer | Jorge de la Rosa | None | |
| 2016-07-21 | Thu | OAK | AL | A | N | 95 | W | 7-3 | 9 | box - pbp - pit | W3 | 38-57 | 5 | 14 | 27 | 2:46 | 14,412 | Matt Moore | Sonny Gray (R) | Matt Moore | Sonny Gray | Alex Colome | |
| 2016-07-22 | Fri | OAK | AL | A | N | 96 | L | 0-1 | 13 | box - pbp - pit | L1 | 38-58 | 5 | 14 | 27 | 3:31 | 15,250 | Jake Odorizzi | Sean Manaea (L) | John Axford | Dylan Floro | None | |
| 2016-07-23 | Sat | OAK | AL | A | N | 97 | L | 3-4 | 9 | box - pbp - pit | L2 | 38-59 | 5 | 14 | 28 | 2:22 | 30,436 | Drew Smyly | Kendall Graveman (R) | Kendall Graveman | Alex Colome | None | |
| 2016-07-24 | Sun | OAK | AL | A | D | 98 | L | 2-3 | 9 | box - pbp - pit | L3 | 38-60 | 5 | 14 | 28 | 2:21 | 17,642 | Blake Snell | Jesse Hahn (R) | Ryan Dull | Erasmo Ramirez | Ryan Madson | |
| 2016-07-26 | Tue | LAN | NL | A | N | 99 | L | 2-3 | 9 | box - pbp - pit | L4 | 38-61 | 5 | 14 | 28 | 2:55 | 46,960 | Chris Archer | Bud Norris (R) | Bud Norris | Chris Archer | Kenley Jansen | |
| 2016-07-27 | Wed | LAN | NL | A | D | 100 | W | 3-1 | 9 | box - pbp - pit | W1 | 39-61 | 5 | 14 | 28 | 3:07 | 43,576 | Matt Moore | Brandon McCarthy (R) | Matt Moore | Brandon McCarthy | Alex Colome | |
| 2016-07-29 | Fri | NYA | AL | H | N | 101 | W | 5-1 | 9 | box - pbp - pit | W2 | 40-61 | 5 | 14 | 28 | 2:58 | 17,856 | Jake Odorizzi | Ivan Nova (R) | Jake Odorizzi | Ivan Nova | Alex Colome | |
| 2016-07-30 | Sat | NYA | AL | H | N | 102 | W | 6-3 | 9 | box - pbp - pit | W3 | 41-61 | 5 | 14 | 27 | 2:47 | 25,883 | Drew Smyly | Nathan Eovaldi (R) | Drew Smyly | Nathan Eovaldi | Alex Colome | |
| 2016-07-31 | Sun | NYA | AL | H | D | 103 | W | 5-3 | 9 | box - pbp - pit | W4 | 42-61 | 5 | 14 | 27 | 3:01 | 18,109 | Blake Snell | Michael Pineda (R) | Blake Snell | Michael Pineda | Alex Colome | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2016-08-01 | Mon | KCA | AL | H | N | 104 | L | 0-3 | 9 | box - pbp - pit | L1 | 42-62 | 5 | 14 | 28 | 2:37 | 13,976 | Chris Archer | Danny Duffy (L) | Danny Duffy | Chris Archer | Kelvin Herrera | |
| 2016-08-02 | Tue | KCA | AL | H | N | 105 | L | 2-3 | 9 | box - pbp - pit | L2 | 42-63 | 5 | 14 | 28 | 3:04 | 12,625 | Matt Andriese | Yordano Ventura (R) | Chris Young | Xavier Cedeno | Kelvin Herrera | |
| 2016-08-03 | Wed | KCA | AL | H | N | 106 | W | 12-0 | 9 | box - pbp - pit | W1 | 43-63 | 5 | 14 | 27 | 2:59 | 11,149 | Jake Odorizzi | Edinson Volquez (R) | Jake Odorizzi | Edinson Volquez | None | |
| 2016-08-04 | Thu | KCA | AL | H | D | 107 | W | 3-2 | 9 | box - pbp - pit | W2 | 44-63 | 5 | 14 | 26 | 2:42 | 13,120 | Drew Smyly | Ian Kennedy (R) | Brad Boxberger | Joakim Soria | Alex Colome | |
| 2016-08-05 | Fri | MIN | AL | H | N | 108 | L | 2-6 | 9 | box - pbp - pit | L1 | 44-64 | 5 | 14 | 27 | 2:57 | 12,161 | Blake Snell | Ervin Santana (R) | Ervin Santana | Erasmo Ramirez | None | |
| 2016-08-06 | Sat | MIN | AL | H | N | 109 | W | 7-3 | 9 | box - pbp - pit | W1 | 45-64 | 5 | 14 | 26 | 3:09 | 15,603 | Chris Archer | Jose Berrios (R) | Chris Archer | Jose Berrios | Alex Colome | |
| 2016-08-07 | Sun | MIN | AL | H | D | 110 | L | 3-6 | 9 | box - pbp - pit | L1 | 45-65 | 5 | 14 | 27 | 3:29 | 12,649 | Matt Andriese | Kyle Gibson (R) | Kyle Gibson | Matt Andriese | Brandon Kintzler | |
| 2016-08-08 | Mon | TOR | AL | A | N | 111 | L | 5-7 | 9 | box - pbp - pit | L2 | 45-66 | 5 | 15 | 28 | 3:13 | 43,812 | Jake Odorizzi | R.A. Dickey (R) | Joaquin Benoit | Xavier Cedeno | Roberto Osuna | |
| 2016-08-09 | Tue | TOR | AL | A | N | 112 | W | 9-2 | 9 | box - pbp - pit | W1 | 46-66 | 5 | 14 | 27 | 2:56 | 43,134 | Drew Smyly | Marco Estrada (R) | Drew Smyly | Marco Estrada | Erasmo Ramirez | |
| 2016-08-10 | Wed | TOR | AL | A | N | 113 | L | 0-7 | 9 | box - pbp - pit | L1 | 46-67 | 5 | 14 | 27 | 3:01 | 45,501 | Blake Snell | J.A. Happ (L) | J.A. Happ | Blake Snell | None | |
| 2016-08-12 | Fri | NYA | AL | A | N | 114 | L | 3-6 | 9 | box - pbp - pit | L2 | 46-68 | 5 | 14 | 28 | 2:51 | 46,459 | Chris Archer | CC Sabathia (L) | CC Sabathia | Chris Archer | Dellin Betances | |
| 2016-08-13 | Sat | NYA | AL | A | D | 115 | L | 4-8 | 9 | box - pbp - pit | L3 | 46-69 | 5 | 15 | 29 | 2:40 | 41,682 | Matt Andriese | Masahiro Tanaka (R) | Masahiro Tanaka | Matt Andriese | None | |
| 2016-08-14 | Sun | NYA | AL | A | D | 116 | W | 12-3 | 9 | box - pbp - pit | W1 | 47-69 | 5 | 14 | 28 | 2:54 | 41,473 | Jake Odorizzi | Luis Severino (R) | Jake Odorizzi | Luis Severino | None | |
| 2016-08-15 | Mon | SDN | NL | H | N | 117 | W | 8-2 | 9 | box - pbp - pit | W2 | 48-69 | 5 | 14 | 27 | 2:50 | 10,417 | Drew Smyly | Luis Perdomo (R) | Drew Smyly | Luis Perdomo | None | |
| 2016-08-16 | Tue | SDN | NL | H | N | 118 | W | 15-1 | 9 | box - pbp - pit | W3 | 49-69 | 5 | 14 | 27 | 3:18 | 10,793 | Blake Snell | Edwin Jackson (R) | Blake Snell | Edwin Jackson | None | |
| 2016-08-17 | Wed | SDN | NL | H | D | 119 | W | 2-0 | 9 | box - pbp - pit | W4 | 50-69 | 5 | 13 | 25 | 2:32 | 10,251 | Chris Archer | Christian Friedrich (L) | Chris Archer | Christian Friedrich | Alex Colome | |
| 2016-08-19 | Fri | TEX | AL | H | N | 120 | L | 2-6 | 9 | box - pbp - pit | L1 | 50-70 | 5 | 14 | 27 | 2:56 | 15,109 | Matt Andriese | Cole Hamels (L) | Cole Hamels | Matt Andriese | None | |
| 2016-08-20 | Sat | TEX | AL | H | N | 121 | W | 8-2 | 9 | box - pbp - pit | W1 | 51-70 | 5 | 13 | 26 | 2:56 | 16,505 | Jake Odorizzi | AJ Griffin (R) | Jake Odorizzi | A.J. Griffin | None | |
| 2016-08-21 | Sun | TEX | AL | H | D | 122 | W | 8-4 | 9 | box - pbp - pit | W2 | 52-70 | 5 | 13 | 26 | 3:01 | 17,685 | Drew Smyly | Martin Perez (L) | Drew Smyly | Martin Perez | None | |
| 2016-08-22 | Mon | BOS | AL | H | N | 123 | L | 2-6 | 9 | box - pbp - pit | L1 | 52-71 | 5 | 13 | 26 | 3:13 | 13,576 | Blake Snell | David Price (L) | David Price | Blake Snell | None | |
| 2016-08-23 | Tue | BOS | AL | H | N | 124 | L | 1-2 | 9 | box - pbp - pit | L2 | 52-72 | 5 | 13 | 26 | 3:09 | 11,249 | Chris Archer | Clay Buchholz (R) | Clay Buchholz | Chris Archer | Craig Kimbrel | |
| 2016-08-24 | Wed | BOS | AL | H | N | 125 | W | 4-3 | 11 | box - pbp - pit | W1 | 53-72 | 5 | 13 | 25 | 3:41 | 11,896 | Matt Andriese | Rick Porcello (R) | Brad Boxberger | Heath Hembree | None | |
| 2016-08-25 | Thu | BOS | AL | H | D | 126 | W | 2-1 | 9 | box - pbp - pit | W2 | 54-72 | 5 | 13 | 24 | 2:32 | 12,059 | Jake Odorizzi | Drew Pomeranz (L) | Jake Odorizzi | Drew Pomeranz | Enny Romero | |
| 2016-08-26 | Fri | HOU | AL | A | N | 127 | L | 4-5 | 9 | box - pbp - pit | L1 | 54-73 | 5 | 13 | 25 | 2:39 | 25,852 | Drew Smyly | Mike Fiers (R) | Ken Giles | Alex Colome | None | |
| 2016-08-27 | Sat | HOU | AL | A | N | 128 | L | 2-6 | 9 | box - pbp - pit | L2 | 54-74 | 5 | 14 | 26 | 2:58 | 36,544 | Blake Snell | Dallas Keuchel (L) | Dallas Keuchel | Blake Snell | None | |
| 2016-08-28 | Sun | HOU | AL | A | D | 129 | W | 10-4 | 9 | box - pbp - pit | W1 | 55-74 | 5 | 14 | 26 | 3:14 | 37,484 | Chris Archer | Doug Fister (R) | Chris Archer | Doug Fister | None | |
| 2016-08-29 | Mon | BOS | AL | A | N | 130 | L | 4-9 | 9 | box - pbp - pit | L1 | 55-75 | 5 | 14 | 25 | 3:11 | 36,948 | Matt Andriese | Rick Porcello (R) | Rick Porcello | Matt Andriese | None | |
| 2016-08-30 | Tue | BOS | AL | A | N | 131 | W | 4-3 | 9 | box - pbp - pit | W1 | 56-75 | 5 | 14 | 24 | 3:11 | 37,083 | Jake Odorizzi | Drew Pomeranz (L) | Enny Romero | Clay Buchholz | Alex Colome | |
| 2016-08-31 | Wed | BOS | AL | A | D | 132 | L | 6-8 | 9 | box - pbp - pit | L1 | 56-76 | 5 | 14 | 25 | 3:10 | 36,786 | Drew Smyly | Steven Wright (R) | Junichi Tazawa | Erasmo Ramirez | Craig Kimbrel | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2016-09-02 | Fri | TOR | AL | H | N | 133 | W | 8-3 | 9 | box - pbp - pit | W1 | 57-76 | 5 | 13 | 24 | 2:52 | 12,602 | Alex Cobb | Marcus Stroman (R) | Danny Farquhar | Marcus Stroman | None | |
| 2016-09-03 | Sat | TOR | AL | H | N | 134 | W | 7-5 | 9 | box - pbp - pit | W2 | 58-76 | 5 | 13 | 24 | 3:06 | 14,353 | Blake Snell | Marco Estrada (R) | Blake Snell | Marco Estrada | Alex Colome | |
| 2016-09-04 | Sun | TOR | AL | H | D | 135 | L | 3-5 | 9 | box - pbp - pit | L1 | 58-77 | 5 | 13 | 24 | 3:18 | 13,884 | Chris Archer | J.A. Happ (L) | Joaquin Benoit | Kevin Jepsen | Roberto Osuna | |
| 2016-09-05 | Mon | BAL | AL | H | D | 136 | L | 3-7 | 9 | box - pbp - pit | L2 | 58-78 | 5 | 13 | 24 | 2:35 | 12,256 | Matt Andriese | Ubaldo Jimenez (R) | Ubaldo Jimenez | Matt Andriese | None | |
| 2016-09-06 | Tue | BAL | AL | H | N | 137 | L | 2-11 | 9 | box - pbp - pit | L3 | 58-79 | 5 | 14 | 25 | 3:08 | 12,207 | Jake Odorizzi | Yovani Gallardo (R) | Yovani Gallardo | Jake Odorizzi | None | |
| 2016-09-07 | Wed | BAL | AL | H | D | 138 | W | 7-6 | 9 | box - pbp - pit | W1 | 59-79 | 5 | 14 | 25 | 3:25 | 10,537 | Drew Smyly | Dylan Bundy (R) | Brad Boxberger | Mychal Givens | Alex Colome | |
| 2016-09-08 | Thu | NYA | AL | A | N | 139 | L | 4-5 | 9 | box - pbp - pit | L1 | 59-80 | 5 | 14 | 25 | 3:21 | 27,631 | Alex Cobb | CC Sabathia (L) | Tom Layne | Erasmo Ramirez | None | |
| 2016-09-09 | Fri | NYA | AL | A | N | 140 | L | 5-7 | 9 | box - pbp - pit | L2 | 59-81 | 5 | 14 | 25 | 3:30 | 30,194 | Blake Snell | Michael Pineda (R) | Adam Warren | Blake Snell | Dellin Betances | |
| 2016-09-10 | Sat | NYA | AL | A | D | 141 | L | 1-5 | 9 | box - pbp - pit | L3 | 59-82 | 5 | 14 | 26 | 2:34 | 33,460 | Chris Archer | Masahiro Tanaka (R) | Masahiro Tanaka | Chris Archer | None | |
| 2016-09-11 | Sun | NYA | AL | A | D | 142 | W | 4-2 | 9 | box - pbp - pit | W1 | 60-82 | 5 | 14 | 25 | 2:58 | 33,087 | Matt Andriese | Luis Cessa (R) | Matt Andriese | Luis Cessa | Alex Colome | |
| 2016-09-12 | Mon | TOR | AL | A | N | 143 | L | 2-3 | 9 | box - pbp - pit | L1 | 60-83 | 5 | 14 | 26 | 2:13 | 35,333 | Jake Odorizzi | Francisco Liriano (L) | Jason Grilli | Brad Boxberger | Roberto Osuna | |
| 2016-09-13 | Tue | TOR | AL | A | N | 144 | W | 6-2 | 9 | box - pbp - pit | W1 | 61-83 | 5 | 14 | 26 | 3:10 | 38,338 | Drew Smyly | Marcus Stroman (R) | Drew Smyly | Marcus Stroman | None | |
| 2016-09-14 | Wed | TOR | AL | A | D | 145 | W | 8-1 | 9 | box - pbp - pit | W2 | 62-83 | 5 | 14 | 26 | 2:58 | 41,001 | Alex Cobb | Marco Estrada (R) | Alex Cobb | Marco Estrada | None | |
| 2016-09-15 | Thu | BAL | AL | A | N | 146 | W | 7-6 | 9 | box - pbp - pit | W3 | 63-83 | 5 | 13 | 24 | 3:27 | 19,233 | Blake Snell | Yovani Gallardo (R) | Brad Boxberger | Yovani Gallardo | Alex Colome | |
| 2016-09-16 | Fri | BAL | AL | A | N | 147 | L | 4-5 | 9 | box - pbp - pit | L1 | 63-84 | 5 | 13 | 24 | 2:44 | 30,094 | Chris Archer | Ubaldo Jimenez (R) | Brad Brach | Brad Boxberger | Zach Britton | |
| 2016-09-17 | Sat | BAL | AL | A | N | 148 | W | 5-2 | 9 | box - pbp - pit | W1 | 64-84 | 5 | 13 | 24 | 3:00 | 27,823 | Matt Andriese | Chris Tillman (R) | Matt Andriese | Chris Tillman | Alex Colome | |
| 2016-09-18 | Sun | BAL | AL | A | D | 149 | L | 1-2 | 9 | box - pbp - pit | L1 | 64-85 | 5 | 14 | 25 | 3:01 | 28,427 | Jake Odorizzi | Wade Miley (L) | Brad Brach | Ryan Garton | Zach Britton | |
| 2016-09-20 | Tue | NYA | AL | H | N | 150 | L | 3-5 | 9 | box - pbp - pit | L2 | 64-86 | 5 | 14 | 25 | 2:49 | 12,732 | Drew Smyly | Michael Pineda (R) | Luis Severino | Brad Boxberger | Dellin Betances | |
| 2016-09-21 | Wed | NYA | AL | H | N | 151 | L | 5-11 | 9 | box - pbp - pit | L3 | 64-87 | 5 | 14 | 25 | 3:06 | 12,192 | Alex Cobb | Masahiro Tanaka (R) | Masahiro Tanaka | Alex Cobb | None | |
| 2016-09-22 | Thu | NYA | AL | H | N | 152 | W | 2-0 | 9 | box - pbp - pit | W1 | 65-87 | 5 | 14 | 25 | 2:37 | 13,355 | Blake Snell | Luis Cessa (R) | Blake Snell | Luis Cessa | Alex Colome | |
| 2016-09-23 | Fri | BOS | AL | H | N | 153 | L | 1-2 | 9 | box - pbp - pit | L1 | 65-88 | 5 | 14 | 25 | 2:52 | 20,543 | Chris Archer | Drew Pomeranz (L) | Drew Pomeranz | Chris Archer | Brad Ziegler | |
| 2016-09-24 | Sat | BOS | AL | H | N | 154 | L | 4-6 | 9 | box - pbp - pit | L2 | 65-89 | 5 | 14 | 25 | 3:10 | 25,641 | Matt Andriese | Rick Porcello (R) | Rick Porcello | Ryan Garton | Craig Kimbrel | |
| 2016-09-25 | Sun | BOS | AL | H | D | 155 | L | 2-3 | 10 | box - pbp - pit | L3 | 65-90 | 5 | 14 | 26 | 4:01 | 26,443 | Jake Odorizzi | Eduardo Rodriguez (L) | Joe Kelly | Eddie Gamboa | None | |
| 2016-09-26 | Mon | CHA | AL | A | N | 156 | L | 1-7 | 9 | box - pbp - pit | L4 | 65-91 | 5 | 14 | 27 | 3:04 | 13,665 | Drew Smyly | James Shields (R) | James Shields | Drew Smyly | None | |
| 2016-09-27 | Tue | CHA | AL | A | N | 157 | L | 6-13 | 9 | box - pbp - pit | L5 | 65-92 | 5 | 14 | 27 | 2:57 | 14,798 | Alex Cobb | Chris Sale (L) | Chris Sale | Alex Cobb | None | |
| 2016-09-28 | Wed | CHA | AL | A | N | 158 | L | 0-1 | 9 | box - pbp - pit | L6 | 65-93 | 5 | 14 | 29 | 2:10 | 12,976 | Blake Snell | Miguel Gonzalez (R) | Miguel Gonzalez | Eddie Gamboa | David Robertson | |
| 2016-09-29 | Thu | CHA | AL | A | N | 159 | W | 5-3 | 9 | box - pbp - pit | W1 | 66-93 | 5 | 14 | 28 | 3:15 | 14,792 | Chris Archer | Jose Quintana (L) | Chris Archer | Jose Quintana | Alex Colome | |
| 2016-09-30 | Fri | TEX | AL | A | N | 160 | L | 1-3 | 9 | box - pbp - pit | L1 | 66-94 | 5 | 14 | 29 | 3:00 | 35,968 | Matt Andriese | Yu Darvish (R) | Yu Darvish | Matt Andriese | Sam Dyson | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2016-10-01 | Sat | TEX | AL | A | N | 161 | W | 4-1 | 9 | box - pbp - pit | W1 | 67-94 | 5 | 14 | 29 | 2:39 | 42,093 | Jake Odorizzi | Colby Lewis (R) | Jake Odorizzi | Colby Lewis | Alex Colome | |
| 2016-10-02 | Sun | TEX | AL | A | D | 162 | W | 6-4 | 10 | box - pbp - pit | W2 | 68-94 | 5 | 14 | 28 | 4:00 | 37,015 | Chase Whitley | Martin Perez (L) | Alex Colome | Tanner Scheppers | Erasmo Ramirez |
Team Splits | Top |
| Category | GP | W | L | Wpct | RF | RA | Diff |
| Season Total | 162 | 68 | 94 | .420 | 672 | 713 | -41 |
| Home Games | 81 | 36 | 45 | .444 | 314 | 338 | -24 |
| Away Games | 81 | 32 | 49 | .395 | 358 | 375 | -17 |
| Night Games | 104 | 41 | 63 | .394 | 432 | 472 | -40 |
| Day Games | 58 | 27 | 31 | .466 | 240 | 241 | -1 |
| March/April | 23 | 11 | 12 | .478 | 76 | 80 | -4 |
| May | 27 | 11 | 16 | .407 | 130 | 131 | -1 |
| June | 28 | 11 | 17 | .393 | 115 | 148 | -33 |
| July | 25 | 9 | 16 | .360 | 90 | 100 | -10 |
| August | 29 | 14 | 15 | .483 | 144 | 118 | +26 |
| Sept/Oct | 30 | 12 | 18 | .400 | 117 | 136 | -19 |
| 1-Run Games | 40 | 13 | 27 | .325 | 125 | 139 | -14 |
| Close Games (1-2-3 Runs) | 98 | 41 | 57 | .418 | 356 | 378 | -22 |
| Blowouts (7+ runs) | 17 | 10 | 7 | .588 | 131 | 91 | +40 |
| Extra Innings | 7 | 4 | 3 | .571 | 23 | 19 | +4 |
| Shutouts | 18 | 8 | 10 | .444 | 36 | 39 | -3 |
| vs LHSP | 44 | 18 | 26 | .409 | 182 | 190 | -8 |
| vs RHSP | 118 | 50 | 68 | .424 | 490 | 523 | -33 |
| vs Division | 76 | 32 | 44 | .421 | 317 | 331 | -14 |
| vs League | 142 | 58 | 84 | .408 | 572 | 629 | -57 |
| InterLeague | 20 | 10 | 10 | .500 | 100 | 84 | +16 |
