| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2012-04-06 | Fri | KCA | AL | H | N | 1 | W | 5-0 | 9 | box - pbp - pit | W1 | 1-0 | 1 | 1 | 1 | 2:22 | 44,106 | Jered Weaver | Bruce Chen (L) | Jered Weaver | Aaron Crow | None | |
| 2012-04-07 | Sat | KCA | AL | H | D | 2 | L | 3-6 | 9 | box - pbp - pit | L1 | 1-1 | 2 | 7 | 16 | 2:46 | 40,022 | Dan Haren | Luke Hochevar (R) | Luke Hochevar | Dan Haren | None | |
| 2012-04-08 | Sun | KCA | AL | H | D | 3 | L | 3-7 | 9 | box - pbp - pit | L2 | 1-2 | 3 | 8 | 19 | 3:15 | 32,227 | Ervin Santana | Jonathan Sanchez (L) | Jonathan Sanchez | Ervin Santana | Jonathan Broxton | |
| 2012-04-09 | Mon | MIN | AL | A | D | 4 | W | 5-1 | 9 | box - pbp - pit | W1 | 2-2 | 2 | 7 | 16 | 2:50 | 39,414 | C.J. Wilson | Nick Blackburn (R) | C.J. Wilson | Nick Blackburn | None | |
| 2012-04-11 | Wed | MIN | AL | A | N | 5 | L | 5-6 | 9 | box - pbp - pit | L1 | 2-3 | 4 | 10 | 21 | 2:47 | 31,413 | Jered Weaver | Carl Pavano (R) | Jeff Gray | Hisanori Takahashi | Matt Capps | |
| 2012-04-12 | Thu | MIN | AL | A | D | 6 | W | 9-10 | 9 | box - pbp - pit | W1 | 3-3 | 3 | 8 | 12 | 3:44 | 31,782 | Dan Haren | Francisco Liriano (L) | Jeff Gray | Rich Thompson | Matt Capps | |
| 2012-04-13 | Fri | NYA | AL | A | D | 7 | L | 0-5 | 9 | box - pbp - pit | L1 | 3-4 | 4 | 11 | 19 | 2:33 | 49,386 | Ervin Santana | Hiroki Kuroda (R) | Hiroki Kuroda | Ervin Santana | None | |
| 2012-04-14 | Sat | NYA | AL | A | D | 8 | W | 7-1 | 9 | box - pbp - pit | W1 | 4-4 | 3 | 7 | 15 | 3:07 | 46,829 | C.J. Wilson | Phil Hughes (R) | C.J. Wilson | Phil Hughes | None | |
| 2012-04-15 | Sun | NYA | AL | A | N | 9 | W | 5-11 | 9 | box - pbp - pit | W2 | 5-4 | 3 | 5 | 10 | 3:32 | 41,055 | Jerome Williams | Ivan Nova (R) | Ivan Nova | Jerome Williams | None | |
| 2012-04-16 | Mon | OAK | AL | H | N | 10 | W | 6-0 | 9 | box - pbp - pit | W3 | 6-4 | 3 | 5 | 10 | 2:48 | 27,338 | Jered Weaver | Brandon McCarthy (R) | Jered Weaver | Brandon McCarthy | None | |
| 2012-04-17 | Tue | OAK | AL | H | N | 11 | L | 3-5 | 9 | box - pbp - pit | L1 | 6-5 | 3 | 6 | 11 | 2:46 | 41,016 | Dan Haren | Tyson Ross (R) | Brian Fuentes | Kevin Jepsen | Grant Balfour | |
| 2012-04-18 | Wed | OAK | AL | H | N | 12 | L | 0-6 | 9 | box - pbp - pit | L2 | 6-6 | 3 | 7 | 15 | 2:44 | 27,217 | Ervin Santana | Bartolo Colon (R) | Bartolo Colon | Ervin Santana | None | |
| 2012-04-19 | Thu | OAK | AL | H | N | 13 | L | 2-4 | 9 | box - pbp - pit | L3 | 6-7 | 4 | 9 | 18 | 3:11 | 27,864 | C.J. Wilson | Tommy Milone (L) | Tom Milone | C.J. Wilson | Grant Balfour | |
| 2012-04-20 | Fri | BAL | AL | H | N | 14 | W | 6-3 | 9 | box - pbp - pit | W1 | 7-7 | 3 | 10 | 16 | 2:49 | 32,272 | Jerome Williams | Brian Matusz (L) | Jerome Williams | Brian Matusz | Jordan Walden | |
| 2012-04-21 | Sat | BAL | AL | H | N | 15 | W | 6-3 | 9 | box - pbp - pit | W2 | 8-7 | 1 | 7 | 11 | 2:24 | 38,054 | Jered Weaver | Jake Arrieta (R) | Jered Weaver | Jake Arrieta | None | |
| 2012-04-22 | Sun | BAL | AL | H | D | 16 | L | 2-3 | 10 | box - pbp - pit | L1 | 8-8 | 2 | 6 | 13 | 3:11 | 38,221 | Dan Haren | Wei-Yin Chen (L) | Pedro Strop | LaTroy Hawkins | Jim Johnson | |
| 2012-04-24 | Tue | TBA | AL | A | N | 17 | L | 0-5 | 9 | box - pbp - pit | L2 | 8-9 | 4 | 11 | 17 | 2:25 | 14,933 | Ervin Santana | David Price (L) | David Price | Ervin Santana | None | |
| 2012-04-25 | Wed | TBA | AL | A | N | 18 | L | 2-3 | 9 | box - pbp - pit | L3 | 8-10 | 4 | 11 | 20 | 3:10 | 14,638 | C.J. Wilson | Jeremy Hellickson (R) | Jeremy Hellickson | C.J. Wilson | Fernando Rodney | |
| 2012-04-26 | Thu | TBA | AL | A | D | 19 | L | 3-4 | 9 | box - pbp - pit | L4 | 8-11 | 4 | 11 | 22 | 2:48 | 15,417 | Jerome Williams | Matt Moore (L) | Brandon Gomes | Jordan Walden | None | |
| 2012-04-27 | Fri | CLE | AL | A | N | 20 | L | 2-3 | 9 | box - pbp - pit | L5 | 8-12 | 4 | 11 | 24 | 2:54 | 12,597 | Jered Weaver | Justin Masterson (R) | Vinnie Pestano | David Carpenter | None | |
| 2012-04-28 | Sat | CLE | AL | A | D | 21 | W | 2-1 | 9 | box - pbp - pit | W1 | 9-12 | 4 | 11 | 22 | 2:32 | 11,316 | Dan Haren | Jeanmar Gomez (R) | Dan Haren | Jeanmar Gomez | Scott Downs | |
| 2012-04-29 | Sun | CLE | AL | A | D | 22 | L | 0-4 | 9 | box - pbp - pit | L1 | 9-13 | 4 | 11 | 23 | 2:22 | 15,421 | Ervin Santana | Derek Lowe (R) | Derek Lowe | Ervin Santana | None | |
| 2012-04-30 | Mon | MIN | AL | H | N | 23 | W | 4-3 | 9 | box - pbp - pit | W1 | 10-13 | 4 | 11 | 22 | 2:27 | 27,027 | C.J. Wilson | Nick Blackburn (R) | C.J. Wilson | Nick Blackburn | Scott Downs | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2012-05-01 | Tue | MIN | AL | H | N | 24 | W | 4-0 | 9 | box - pbp - pit | W2 | 11-13 | 4 | 11 | 22 | 2:10 | 30,039 | Jerome Williams | Francisco Liriano (L) | Jerome Williams | Francisco Liriano | None | |
| 2012-05-02 | Wed | MIN | AL | H | N | 25 | W | 9-0 | 9 | box - pbp - pit | W3 | 12-13 | 3 | 9 | 18 | 2:28 | 27,288 | Jered Weaver | Liam Hendriks (R) | Jered Weaver | Liam Hendriks | None | |
| 2012-05-03 | Thu | TOR | AL | H | N | 26 | L | 0-5 | 9 | box - pbp - pit | L1 | 12-14 | 3 | 9 | 19 | 2:11 | 28,359 | Dan Haren | Brandon Morrow (R) | Brandon Morrow | Dan Haren | None | |
| 2012-05-04 | Fri | TOR | AL | H | N | 27 | L | 0-4 | 9 | box - pbp - pit | L2 | 12-15 | 3 | 10 | 22 | 2:10 | 33,160 | Ervin Santana | Henderson Alvarez (R) | Henderson Alvarez | Ervin Santana | None | |
| 2012-05-05 | Sat | TOR | AL | H | N | 28 | W | 6-2 | 9 | box - pbp - pit | W1 | 13-15 | 3 | 9 | 18 | 2:54 | 39,018 | C.J. Wilson | Kyle Drabek (R) | C.J. Wilson | Kyle Drabek | None | |
| 2012-05-06 | Sun | TOR | AL | H | D | 29 | W | 4-3 | 9 | box - pbp - pit | W2 | 14-15 | 3 | 9 | 18 | 2:51 | 37,548 | Jerome Williams | Drew Hutchison (R) | Jerome Williams | Drew Hutchison | LaTroy Hawkins | |
| 2012-05-07 | Mon | MIN | AL | A | N | 30 | W | 8-3 | 9 | box - pbp - pit | W3 | 15-15 | 3 | 8 | 14 | 3:01 | 31,382 | Jered Weaver | Francisco Liriano (L) | Jered Weaver | Francisco Liriano | None | |
| 2012-05-08 | Tue | MIN | AL | A | N | 31 | L | 0-5 | 9 | box - pbp - pit | L1 | 15-16 | 3 | 9 | 18 | 2:37 | 30,776 | Dan Haren | Scott Diamond (L) | Scott Diamond | Dan Haren | None | |
| 2012-05-09 | Wed | MIN | AL | A | N | 32 | W | 6-2 | 9 | box - pbp - pit | W1 | 16-16 | 2 | 8 | 16 | 2:42 | 31,915 | Ervin Santana | Carl Pavano (R) | Ervin Santana | Carl Pavano | None | |
| 2012-05-11 | Fri | TEX | AL | A | N | 33 | W | 3-10 | 9 | box - pbp - pit | W2 | 17-16 | 2 | 8 | 13 | 3:02 | 48,201 | C.J. Wilson | Yu Darvish (R) | Yu Darvish | C.J. Wilson | None | |
| 2012-05-12 | Sat | TEX | AL | A | D | 34 | W | 4-2 | 9 | box - pbp - pit | W3 | 18-16 | 2 | 6 | 9 | 2:54 | 47,699 | C.J. Wilson | Matt Harrison (L) | David Carpenter | Matt Harrison | Scott Downs | |
| 2012-05-13 | Sun | TEX | AL | A | N | 35 | W | 6-13 | 9 | box - pbp - pit | W4 | 19-16 | 1 | 4 | 9 | 3:27 | 46,669 | Jered Weaver | Neftali Feliz (R) | Neftali Feliz | Jered Weaver | None | |
| 2012-05-14 | Mon | OAK | AL | H | N | 36 | L | 0-5 | 9 | box - pbp - pit | L1 | 19-17 | 2 | 6 | 12 | 2:56 | 32,851 | Dan Haren | Tyson Ross (R) | Tyson Ross | Dan Haren | None | |
| 2012-05-15 | Tue | OAK | AL | H | D | 37 | W | 4-0 | 9 | box - pbp - pit | W1 | 20-17 | 1 | 4 | 8 | 2:26 | 31,762 | Ervin Santana | Bartolo Colon (R) | Ervin Santana | Bartolo Colon | None | |
| 2012-05-16 | Wed | CHA | AL | H | N | 38 | W | 7-2 | 9 | box - pbp - pit | W2 | 21-17 | 1 | 3 | 6 | 2:25 | 39,027 | Jerome Williams | Gavin Floyd (R) | Jerome Williams | Gavin Floyd | None | |
| 2012-05-17 | Thu | CHA | AL | H | D | 39 | L | 1-6 | 9 | box - pbp - pit | L1 | 21-18 | 1 | 4 | 9 | 3:10 | 30,786 | C.J. Wilson | Chris Sale (L) | Chris Sale | C.J. Wilson | None | |
| 2012-05-18 | Fri | SDN | NL | A | N | 40 | W | 7-2 | 9 | box - pbp - pit | W1 | 22-18 | 1 | 3 | 7 | 3:05 | 31,389 | Jered Weaver | Jeff Suppan (R) | Jered Weaver | Jeff Suppan | None | |
| 2012-05-19 | Sat | SDN | NL | A | N | 41 | L | 2-3 | 9 | box - pbp - pit | L1 | 22-19 | 1 | 5 | 11 | 2:47 | 43,427 | Dan Haren | Eric Stults (L) | Luke Gregerson | Dan Haren | Dale Thayer | |
| 2012-05-20 | Sun | SDN | NL | A | D | 42 | L | 2-3 | 13 | box - pbp - pit | L2 | 22-20 | 1 | 6 | 14 | 4:23 | 33,975 | Ervin Santana | Anthony Bass (R) | Miles Mikolas | David Pauley | None | |
| 2012-05-21 | Mon | OAK | AL | A | N | 43 | L | 1-2 | 9 | box - pbp - pit | L3 | 22-21 | 2 | 9 | 17 | 2:46 | 11,292 | Jerome Williams | Tommy Milone (L) | Tom Milone | Jerome Williams | Brian Fuentes | |
| 2012-05-22 | Tue | OAK | AL | A | N | 44 | W | 5-0 | 9 | box - pbp - pit | W1 | 23-21 | 1 | 6 | 14 | 2:45 | 12,894 | C.J. Wilson | Graham Godfrey (R) | C.J. Wilson | Graham Godfrey | None | |
| 2012-05-23 | Wed | OAK | AL | A | D | 45 | W | 3-1 | 11 | box - pbp - pit | W2 | 24-21 | 1 | 5 | 11 | 3:11 | 23,617 | Jered Weaver | Jarrod Parker (R) | Jordan Walden | Jordan Norberto | Ernesto Frieri | |
| 2012-05-23 | Wed | OAK | AL | A | D | 45 | W | 3-1 | 11 | box - pbp - pit | W3 | 24-21 | 1 | 5 | 11 | 3:11 | 23,617 | Jered Weaver | Kyle Parker (R) | Jordan Walden | Jordan Norberto | Ernesto Frieri | |
| 2012-05-24 | Thu | SEA | AL | A | N | 46 | W | 3-0 | 9 | box - pbp - pit | W4 | 25-21 | 1 | 5 | 10 | 2:19 | 18,048 | Dan Haren | Jason Vargas (L) | Dan Haren | Jason Vargas | None | |
| 2012-05-25 | Fri | SEA | AL | A | N | 47 | W | 6-4 | 9 | box - pbp - pit | W5 | 26-21 | 1 | 5 | 10 | 2:52 | 23,517 | Ervin Santana | Blake Beavan (R) | Jason Isringhausen | Brandon League | Scott Downs | |
| 2012-05-26 | Sat | SEA | AL | A | D | 48 | W | 5-3 | 9 | box - pbp - pit | W6 | 27-21 | 1 | 4 | 8 | 3:07 | 29,483 | Jerome Williams | Felix Hernandez (R) | Jerome Williams | Felix Hernandez | Ernesto Frieri | |
| 2012-05-27 | Sun | SEA | AL | A | D | 49 | W | 4-2 | 9 | box - pbp - pit | W7 | 28-21 | 1 | 4 | 7 | 2:30 | 24,467 | C.J. Wilson | Hector Noesi (R) | C.J. Wilson | Hector Noesi | Scott Downs | |
| 2012-05-28 | Mon | NYA | AL | H | N | 50 | W | 9-8 | 9 | box - pbp - pit | W8 | 29-21 | 1 | 4 | 7 | 3:38 | 44,016 | Jered Weaver | Phil Hughes (R) | Jordan Walden | Cory Wade | None | |
| 2012-05-29 | Tue | NYA | AL | H | N | 51 | W | 5-1 | 9 | box - pbp - pit | W9 | 30-21 | 1 | 3 | 6 | 2:37 | 42,065 | Dan Haren | Andy Pettitte (L) | Dan Haren | Andy Pettitte | None | |
| 2012-05-30 | Wed | NYA | AL | H | N | 52 | L | 5-6 | 9 | box - pbp - pit | L1 | 30-22 | 1 | 3 | 7 | 3:06 | 40,111 | Ervin Santana | Ivan Nova (R) | Ivan Nova | Hisanori Takahashi | Rafael Soriano | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2012-06-01 | Fri | TEX | AL | H | N | 53 | W | 4-2 | 9 | box - pbp - pit | W1 | 31-22 | 1 | 2 | 5 | 2:31 | 40,080 | Jerome Williams | Colby Lewis (R) | Jerome Williams | Colby Lewis | Ernesto Frieri | |
| 2012-06-02 | Sat | TEX | AL | H | N | 54 | W | 3-2 | 9 | box - pbp - pit | W2 | 32-22 | 1 | 1 | 4 | 3:34 | 44,227 | C.J. Wilson | Yu Darvish (R) | Bobby Cassevah | Yu Darvish | Ernesto Frieri | |
| 2012-06-03 | Sun | TEX | AL | H | D | 55 | L | 3-7 | 9 | box - pbp - pit | L1 | 32-23 | 1 | 3 | 7 | 3:09 | 42,465 | Dan Haren | Matt Harrison (L) | Matt Harrison | Dan Haren | None | |
| 2012-06-04 | Mon | SEA | AL | H | N | 56 | L | 6-8 | 9 | box - pbp - pit | L2 | 32-24 | 1 | 4 | 8 | 3:14 | 36,079 | Ervin Santana | Jason Vargas (L) | Jason Vargas | Ervin Santana | Tom Wilhelmsen | |
| 2012-06-05 | Tue | SEA | AL | H | N | 57 | W | 6-1 | 9 | box - pbp - pit | W1 | 33-24 | 1 | 4 | 8 | 2:29 | 35,021 | Garrett Richards | Blake Beavan (R) | Garrett Richards | Blake Beavan | None | |
| 2012-06-06 | Wed | SEA | AL | H | N | 58 | L | 6-8 | 9 | box - pbp - pit | L1 | 33-25 | 1 | 4 | 8 | 3:14 | 37,342 | Jerome Williams | Hector Noesi (R) | Shawn Kelley | Jerome Williams | Tom Wilhelmsen | |
| 2012-06-08 | Fri | COL | NL | A | N | 59 | W | 7-2 | 9 | box - pbp - pit | W1 | 34-25 | 1 | 2 | 5 | 2:48 | 41,814 | C.J. Wilson | Alex White (R) | C.J. Wilson | Alex White | None | |
| 2012-06-09 | Sat | COL | NL | A | D | 60 | L | 11-5 | 9 | box - pbp - pit | L1 | 34-26 | 1 | 4 | 8 | 3:21 | 37,801 | Dan Haren | Jeff Francis (L) | Dan Haren | Jeff Francis | None | |
| 2012-06-10 | Sun | COL | NL | A | D | 61 | L | 10-8 | 9 | box - pbp - pit | L2 | 34-27 | 1 | 5 | 10 | 3:33 | 37,722 | Ervin Santana | Christian Friedrich (L) | Ervin Santana | Christian Friedrich | Scott Downs | |
| 2012-06-11 | Mon | LAN | NL | A | N | 62 | W | 3-2 | 9 | box - pbp - pit | W1 | 35-27 | 1 | 4 | 7 | 3:59 | 50,559 | Garrett Richards | Chris Capuano (L) | Jason Isringhausen | Kenley Jansen | Ernesto Frieri | |
| 2012-06-12 | Tue | LAN | NL | A | N | 63 | L | 2-5 | 9 | box - pbp - pit | L1 | 35-28 | 1 | 4 | 8 | 2:49 | 55,279 | Jerome Williams | Aaron Harang (R) | Jamey Wright | Jerome Williams | Kenley Jansen | |
| 2012-06-13 | Wed | LAN | NL | A | N | 64 | W | 2-1 | 9 | box - pbp - pit | W1 | 36-28 | 1 | 4 | 8 | 3:09 | 43,494 | C.J. Wilson | Nathan Eovaldi (R) | LaTroy Hawkins | Kenley Jansen | Ernesto Frieri | |
| 2012-06-15 | Fri | ARI | NL | H | N | 65 | L | 0-5 | 9 | box - pbp - pit | L1 | 36-29 | 1 | 6 | 10 | 2:34 | 37,096 | Dan Haren | Trevor Cahill (R) | Trevor Cahill | Dan Haren | None | |
| 2012-06-16 | Sat | ARI | NL | H | N | 66 | W | 2-0 | 9 | box - pbp - pit | W1 | 37-29 | 1 | 5 | 9 | 2:28 | 42,483 | Ervin Santana | Joe Saunders (L) | Ervin Santana | Joe Saunders | None | |
| 2012-06-17 | Sun | ARI | NL | H | D | 67 | W | 2-0 | 9 | box - pbp - pit | W2 | 38-29 | 1 | 4 | 7 | 2:27 | 42,222 | Garrett Richards | Ian Kennedy (R) | Garrett Richards | Ian Kennedy | Ernesto Frieri | |
| 2012-06-18 | Mon | SFN | NL | H | N | 68 | L | 3-5 | 9 | box - pbp - pit | L1 | 38-30 | 1 | 5 | 9 | 3:21 | 41,234 | Jerome Williams | Matt Cain (R) | Matt Cain | Jerome Williams | Santiago Casilla | |
| 2012-06-19 | Tue | SFN | NL | H | N | 69 | L | 12-5 | 9 | box - pbp - pit | L2 | 38-31 | 1 | 5 | 10 | 3:21 | 38,010 | C.J. Wilson | Barry Zito (L) | C.J. Wilson | Barry Zito | None | |
| 2012-06-20 | Wed | SFN | NL | H | N | 70 | W | 6-0 | 9 | box - pbp - pit | W1 | 39-31 | 1 | 5 | 9 | 2:39 | 40,321 | Jered Weaver | Ryan Vogelsong (R) | Jered Weaver | Ryan Vogelsong | None | |
| 2012-06-22 | Fri | LAN | NL | H | N | 71 | W | 8-5 | 9 | box - pbp - pit | W2 | 40-31 | 1 | 4 | 9 | 3:20 | 44,548 | Dan Haren | Chad Billingsley (R) | Dan Haren | Chad Billingsley | Ernesto Frieri | |
| 2012-06-23 | Sat | LAN | NL | H | D | 72 | L | 1-3 | 9 | box - pbp - pit | L1 | 40-32 | 1 | 5 | 10 | 2:43 | 44,512 | Ervin Santana | Chris Capuano (L) | Chris Capuano | Ervin Santana | Kenley Jansen | |
| 2012-06-24 | Sun | LAN | NL | H | D | 73 | W | 5-3 | 9 | box - pbp - pit | W1 | 41-32 | 1 | 5 | 10 | 3:39 | 43,975 | Garrett Richards | Aaron Harang (R) | Scott Downs | Josh Lindblom | Ernesto Frieri | |
| 2012-06-26 | Tue | BAL | AL | A | N | 74 | W | 7-3 | 9 | box - pbp - pit | W2 | 42-32 | 1 | 3 | 6 | 2:53 | 24,296 | C.J. Wilson | Brian Matusz (L) | C.J. Wilson | Brian Matusz | None | |
| 2012-06-27 | Wed | BAL | AL | A | N | 75 | W | 13-1 | 9 | box - pbp - pit | W3 | 43-32 | 1 | 3 | 6 | 2:49 | 18,055 | Jered Weaver | Jason Hammel (R) | Jered Weaver | Jason Hammel | None | |
| 2012-06-28 | Thu | TOR | AL | A | N | 76 | W | 9-7 | 9 | box - pbp - pit | W4 | 44-32 | 1 | 2 | 3 | 3:16 | 24,668 | Dan Haren | Brett Cecil (L) | Dan Haren | Brett Cecil | Ernesto Frieri | |
| 2012-06-29 | Fri | TOR | AL | A | N | 77 | L | 5-7 | 9 | box - pbp - pit | L1 | 44-33 | 1 | 3 | 6 | 3:12 | 24,538 | Ervin Santana | Carlos Villanueva (R) | Francisco Cordero | Jordan Walden | Casey Janssen | |
| 2012-06-30 | Sat | TOR | AL | A | D | 78 | W | 2-11 | 9 | box - pbp - pit | W1 | 45-33 | 1 | 2 | 3 | 2:44 | 29,287 | Garrett Richards | Henderson Alvarez (R) | Henderson Alvarez | Garrett Richards | None | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2012-07-01 | Sun | TOR | AL | A | D | 79 | L | 10-6 | 9 | box - pbp - pit | L1 | 45-34 | 1 | 3 | 6 | 3:29 | 34,853 | C.J. Wilson | Aaron Laffey (L) | Jason Isringhausen | Francisco Cordero | None | |
| 2012-07-02 | Mon | CLE | AL | A | N | 80 | W | 3-0 | 9 | box - pbp - pit | W1 | 46-34 | 1 | 2 | 2 | 2:34 | 21,616 | Jered Weaver | Ubaldo Jimenez (R) | Jered Weaver | Ubaldo Jimenez | Scott Downs | |
| 2012-07-03 | Tue | CLE | AL | A | N | 81 | L | 5-9 | 9 | box - pbp - pit | L1 | 46-35 | 1 | 2 | 5 | 2:37 | 29,292 | Dan Haren | Zach McAllister (R) | Zach McAllister | Dan Haren | None | |
| 2012-07-04 | Wed | CLE | AL | A | D | 82 | W | 3-12 | 9 | box - pbp - pit | W1 | 47-35 | 1 | 2 | 4 | 2:55 | 20,979 | Ervin Santana | Derek Lowe (R) | Derek Lowe | Ervin Santana | None | |
| 2012-07-05 | Thu | BAL | AL | H | N | 83 | W | 9-7 | 9 | box - pbp - pit | W2 | 48-35 | 1 | 2 | 3 | 3:21 | 38,104 | Garrett Richards | Jake Arrieta (R) | LaTroy Hawkins | Luis Ayala | Ernesto Frieri | |
| 2012-07-06 | Fri | BAL | AL | H | N | 84 | L | 2-3 | 9 | box - pbp - pit | L1 | 48-36 | 1 | 2 | 4 | 2:47 | 42,716 | C.J. Wilson | Miguel Gonzalez (R) | Miguel Gonzalez | C.J. Wilson | Jim Johnson | |
| 2012-07-07 | Sat | BAL | AL | H | N | 85 | W | 3-0 | 9 | box - pbp - pit | W1 | 49-36 | 1 | 2 | 4 | 2:20 | 41,147 | Jered Weaver | Jason Hammel (R) | Jered Weaver | Jason Hammel | Scott Downs | |
| 2012-07-08 | Sun | BAL | AL | H | D | 86 | W | 6-0 | 9 | box - pbp - pit | W2 | 50-36 | 1 | 2 | 2 | 2:32 | 37,108 | Brad Mills | Wei-Yin Chen (L) | Brad Mills | Wei-Yin Chen | None | |
| 2012-07-13 | Fri | NYA | AL | A | N | 87 | L | 5-6 | 9 | box - pbp - pit | L1 | 50-37 | 1 | 2 | 3 | 2:58 | 47,873 | C.J. Wilson | Hiroki Kuroda (R) | Chad Qualls | Scott Downs | Rafael Soriano | |
| 2012-07-14 | Sat | NYA | AL | A | D | 88 | L | 3-5 | 9 | box - pbp - pit | L2 | 50-38 | 1 | 2 | 4 | 2:53 | 47,789 | Jerome Williams | Freddy Garcia (R) | Freddy Garcia | Jerome Williams | Rafael Soriano | |
| 2012-07-15 | Sun | NYA | AL | A | D | 89 | L | 10-8 | 9 | box - pbp - pit | L3 | 50-39 | 1 | 3 | 5 | 3:31 | 46,679 | Jered Weaver | Ivan Nova (R) | Jered Weaver | Ivan Nova | Kevin Jepsen | |
| 2012-07-16 | Mon | DET | AL | A | N | 90 | L | 6-8 | 9 | box - pbp - pit | L4 | 50-40 | 1 | 3 | 5 | 3:08 | 36,806 | Ervin Santana | Rick Porcello (R) | Octavio Dotel | LaTroy Hawkins | Jose Valverde | |
| 2012-07-17 | Tue | DET | AL | A | N | 91 | W | 13-0 | 9 | box - pbp - pit | W1 | 51-40 | 1 | 3 | 5 | 3:09 | 33,950 | Garrett Richards | Jacob Turner (R) | Garrett Richards | Jacob Turner | None | |
| 2012-07-18 | Wed | DET | AL | A | N | 92 | L | 2-7 | 9 | box - pbp - pit | L1 | 51-41 | 1 | 3 | 5 | 2:28 | 37,915 | C.J. Wilson | Doug Fister (R) | Doug Fister | C.J. Wilson | None | |
| 2012-07-19 | Thu | DET | AL | A | D | 93 | L | 1-5 | 9 | box - pbp - pit | L2 | 51-42 | 2 | 5 | 8 | 2:47 | 40,311 | Jerome Williams | Max Scherzer (R) | Max Scherzer | Jerome Williams | None | |
| 2012-07-20 | Fri | TEX | AL | H | N | 94 | W | 6-1 | 9 | box - pbp - pit | W1 | 52-42 | 1 | 3 | 6 | 2:35 | 43,936 | Jered Weaver | Derek Holland (L) | Jered Weaver | Derek Holland | None | |
| 2012-07-21 | Sat | TEX | AL | H | D | 95 | L | 2-9 | 9 | box - pbp - pit | L1 | 52-43 | 2 | 4 | 8 | 3:13 | 39,086 | Ervin Santana | Yu Darvish (R) | Yu Darvish | Ervin Santana | None | |
| 2012-07-22 | Sun | TEX | AL | H | N | 96 | W | 7-4 | 9 | box - pbp - pit | W1 | 53-43 | 1 | 3 | 7 | 3:09 | 42,160 | Dan Haren | Matt Harrison (L) | Dan Haren | Matt Harrison | None | |
| 2012-07-23 | Mon | KCA | AL | H | N | 97 | W | 6-3 | 9 | box - pbp - pit | W2 | 54-43 | 1 | 3 | 7 | 3:21 | 35,047 | C.J. Wilson | Bruce Chen (L) | Kevin Jepsen | Greg Holland | Scott Downs | |
| 2012-07-24 | Tue | KCA | AL | H | N | 98 | L | 1-4 | 9 | box - pbp - pit | L1 | 54-44 | 1 | 3 | 7 | 2:54 | 35,051 | Garrett Richards | Will Smith (L) | Will Smith | Garrett Richards | Jonathan Broxton | |
| 2012-07-25 | Wed | KCA | AL | H | D | 99 | L | 11-6 | 9 | box - pbp - pit | L2 | 54-45 | 2 | 4 | 8 | 3:07 | 39,107 | Jered Weaver | Luke Hochevar (R) | Jered Weaver | Luke Hochevar | None | |
| 2012-07-27 | Fri | TBA | AL | H | N | 100 | W | 3-1 | 9 | box - pbp - pit | W1 | 55-45 | 1 | 3 | 7 | 2:33 | 40,136 | Dan Haren | Alex Cobb (R) | Dan Haren | Alex Cobb | Ernesto Frieri | |
| 2012-07-28 | Sat | TBA | AL | H | N | 101 | L | 0-3 | 9 | box - pbp - pit | L1 | 55-46 | 1 | 4 | 9 | 2:57 | 41,232 | C.J. Wilson | Matt Moore (L) | Matt Moore | C.J. Wilson | Fernando Rodney | |
| 2012-07-29 | Sun | TBA | AL | H | D | 102 | L | 0-2 | 9 | box - pbp - pit | L2 | 55-47 | 2 | 5 | 10 | 2:49 | 35,477 | Zack Greinke | Jeremy Hellickson (R) | Jeremy Hellickson | Zack Greinke | Fernando Rodney | |
| 2012-07-30 | Mon | TEX | AL | A | N | 103 | L | 15-8 | 9 | box - pbp - pit | L3 | 55-48 | 3 | 7 | 12 | 3:06 | 36,111 | Ervin Santana | Roy Oswalt (R) | Ervin Santana | Roy Oswalt | Jerome Williams | |
| 2012-07-31 | Tue | TEX | AL | A | N | 104 | W | 6-2 | 9 | box - pbp - pit | W1 | 56-48 | 2 | 5 | 10 | 2:37 | 34,918 | Jered Weaver | Derek Holland (L) | Jered Weaver | Derek Holland | None | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2012-08-01 | Wed | TEX | AL | A | N | 105 | L | 10-11 | 10 | box - pbp - pit | L1 | 56-49 | 2 | 6 | 12 | 4:01 | 42,832 | Garrett Richards | Yu Darvish (R) | Joe Nathan | Jason Isringhausen | None | |
| 2012-08-02 | Thu | TEX | AL | A | N | 106 | W | 9-15 | 9 | box - pbp - pit | W1 | 57-49 | 2 | 6 | 11 | 4:01 | 40,281 | C.J. Wilson | Ryan Dempster (R) | Roy Oswalt | David Carpenter | None | |
| 2012-08-03 | Fri | CHA | AL | A | N | 107 | L | 6-8 | 10 | box - pbp - pit | L1 | 57-50 | 3 | 8 | 13 | 3:35 | 32,060 | Zack Greinke | Philip Humber (R) | Matt Thornton | Hisanori Takahashi | None | |
| 2012-08-04 | Sat | CHA | AL | A | N | 108 | W | 6-5 | 10 | box - pbp - pit | W1 | 58-50 | 2 | 6 | 11 | 3:26 | 28,571 | Ervin Santana | Gavin Floyd (R) | Kevin Jepsen | Matt Thornton | Ernesto Frieri | |
| 2012-08-05 | Sun | CHA | AL | A | D | 109 | L | 2-4 | 9 | box - pbp - pit | L1 | 58-51 | 2 | 6 | 11 | 2:58 | 30,202 | Dan Haren | Francisco Liriano (L) | Nate Jones | Jason Isringhausen | Addison Reed | |
| 2012-08-06 | Mon | OAK | AL | A | N | 110 | W | 4-0 | 9 | box - pbp - pit | W1 | 59-51 | 2 | 6 | 11 | 2:33 | 13,341 | Jered Weaver | Jarrod Parker (R) | Jered Weaver | Jarrod Parker | None | |
| 2012-08-06 | Mon | OAK | AL | A | N | 110 | W | 4-0 | 9 | box - pbp - pit | W2 | 59-51 | 2 | 6 | 11 | 2:33 | 13,341 | Jered Weaver | Kyle Parker (R) | Jered Weaver | Jarrod Parker | None | |
| 2012-08-07 | Tue | OAK | AL | A | N | 111 | W | 4-10 | 9 | box - pbp - pit | W3 | 60-51 | 2 | 6 | 10 | 2:58 | 15,458 | C.J. Wilson | Bartolo Colon (R) | Bartolo Colon | C.J. Wilson | None | |
| 2012-08-08 | Wed | OAK | AL | A | D | 112 | L | 8-9 | 9 | box - pbp - pit | L1 | 60-52 | 2 | 7 | 12 | 3:40 | 21,150 | Zack Greinke | Dan Straily (R) | Pat Neshek | LaTroy Hawkins | Ryan Cook | |
| 2012-08-10 | Fri | SEA | AL | H | N | 113 | W | 6-5 | 9 | box - pbp - pit | W1 | 61-52 | 1 | 5 | 9 | 2:31 | 39,016 | Ervin Santana | Felix Hernandez (R) | Ernesto Frieri | Josh Kinney | None | |
| 2012-08-11 | Sat | SEA | AL | H | N | 114 | L | 4-7 | 9 | box - pbp - pit | L1 | 61-53 | 2 | 7 | 12 | 2:35 | 38,722 | Dan Haren | Hisashi Iwakuma (R) | Hisashi Iwakuma | Dan Haren | None | |
| 2012-08-12 | Sun | SEA | AL | H | D | 115 | L | 1-4 | 9 | box - pbp - pit | L2 | 61-54 | 2 | 7 | 12 | 2:38 | 36,505 | Jered Weaver | Jason Vargas (L) | Jason Vargas | Jered Weaver | Tom Wilhelmsen | |
| 2012-08-13 | Mon | CLE | AL | H | N | 116 | L | 2-6 | 9 | box - pbp - pit | L3 | 61-55 | 2 | 7 | 12 | 3:13 | 36,620 | C.J. Wilson | Justin Masterson (R) | Justin Masterson | C.J. Wilson | Chris Perez | |
| 2012-08-14 | Tue | CLE | AL | H | N | 117 | W | 9-6 | 9 | box - pbp - pit | W1 | 62-55 | 2 | 7 | 12 | 2:59 | 39,827 | Zack Greinke | Ubaldo Jimenez (R) | Zack Greinke | Ubaldo Jimenez | Ernesto Frieri | |
| 2012-08-15 | Wed | CLE | AL | H | N | 118 | W | 8-4 | 9 | box - pbp - pit | W2 | 63-55 | 1 | 6 | 11 | 2:47 | 37,554 | Ervin Santana | Roberto Hernandez (R) | Ervin Santana | Fausto Carmona | None | |
| 2012-08-16 | Thu | TBA | AL | H | N | 119 | L | 0-7 | 9 | box - pbp - pit | L1 | 63-56 | 1 | 6 | 11 | 2:40 | 38,591 | Dan Haren | David Price (L) | David Price | Dan Haren | None | |
| 2012-08-17 | Fri | TBA | AL | H | N | 120 | W | 3-12 | 9 | box - pbp - pit | W1 | 64-56 | 1 | 6 | 11 | 2:52 | 37,298 | Jered Weaver | James Shields (R) | James Shields | Jered Weaver | None | |
| 2012-08-18 | Sat | TBA | AL | H | N | 121 | W | 8-10 | 9 | box - pbp - pit | W2 | 65-56 | 1 | 5 | 10 | 3:31 | 41,086 | C.J. Wilson | Alex Cobb (R) | Jake McGee | Kevin Jepsen | Fernando Rodney | |
| 2012-08-19 | Sun | TBA | AL | H | D | 122 | L | 3-8 | 9 | box - pbp - pit | L1 | 65-57 | 1 | 6 | 11 | 3:14 | 36,789 | Zack Greinke | Matt Moore (L) | Matt Moore | Zack Greinke | None | |
| 2012-08-21 | Tue | BOS | AL | A | N | 123 | W | 5-3 | 9 | box - pbp - pit | W1 | 66-57 | 1 | 5 | 10 | 3:00 | 37,794 | Ervin Santana | Aaron Cook (R) | Ervin Santana | Aaron Cook | Ernesto Frieri | |
| 2012-08-22 | Wed | BOS | AL | A | N | 124 | W | 7-3 | 9 | box - pbp - pit | W2 | 67-57 | 1 | 5 | 9 | 3:14 | 37,373 | Jered Weaver | Clay Buchholz (R) | Jered Weaver | Clay Buchholz | None | |
| 2012-08-23 | Thu | BOS | AL | A | N | 125 | W | 14-13 | 10 | box - pbp - pit | W3 | 68-57 | 1 | 6 | 9 | 4:34 | 37,829 | C.J. Wilson | Franklin Morales (L) | Ernesto Frieri | Alfredo Aceves | None | |
| 2012-08-24 | Fri | DET | AL | A | N | 126 | W | 2-1 | 9 | box - pbp - pit | W4 | 69-57 | 1 | 5 | 8 | 3:01 | 39,356 | Zack Greinke | Rick Porcello (R) | Zack Greinke | Rick Porcello | Garrett Richards | |
| 2012-08-25 | Sat | DET | AL | A | N | 127 | L | 3-5 | 9 | box - pbp - pit | L1 | 69-58 | 1 | 5 | 9 | 2:58 | 41,970 | Dan Haren | Drew Smyly (L) | Octavio Dotel | Garrett Richards | Jose Valverde | |
| 2012-08-26 | Sun | DET | AL | A | D | 128 | L | 2-5 | 9 | box - pbp - pit | L2 | 69-59 | 1 | 5 | 9 | 2:44 | 40,074 | Ervin Santana | Max Scherzer (R) | Max Scherzer | Ervin Santana | None | |
| 2012-08-28 | Tue | BOS | AL | H | N | 129 | W | 6-5 | 9 | box - pbp - pit | W1 | 70-59 | 1 | 5 | 8 | 3:01 | 38,745 | Jered Weaver | Clay Buchholz (R) | Kevin Jepsen | Alfredo Aceves | None | |
| 2012-08-29 | Wed | BOS | AL | H | N | 130 | L | 10-3 | 9 | box - pbp - pit | L1 | 70-60 | 2 | 6 | 9 | 3:06 | 37,841 | C.J. Wilson | Zach Stewart (R) | C.J. Wilson | Zach Stewart | None | |
| 2012-08-30 | Thu | BOS | AL | H | N | 131 | W | 5-2 | 9 | box - pbp - pit | W1 | 71-60 | 1 | 5 | 8 | 2:43 | 39,013 | Zack Greinke | Jon Lester (L) | Zack Greinke | Jon Lester | Ernesto Frieri | |
| 2012-08-31 | Fri | SEA | AL | A | N | 132 | W | 9-1 | 9 | box - pbp - pit | W2 | 72-60 | 1 | 5 | 8 | 3:04 | 17,739 | Dan Haren | Kevin Millwood (R) | Dan Haren | Kevin Millwood | None | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2012-09-01 | Sat | SEA | AL | A | D | 133 | W | 5-2 | 9 | box - pbp - pit | W3 | 73-60 | 1 | 4 | 7 | 3:03 | 22,910 | Ervin Santana | Felix Hernandez (R) | Ervin Santana | Felix Hernandez | Ernesto Frieri | |
| 2012-09-02 | Sun | SEA | AL | A | D | 134 | L | 1-2 | 9 | box - pbp - pit | L1 | 73-61 | 2 | 5 | 8 | 2:48 | 20,584 | Jered Weaver | Hisashi Iwakuma (R) | Hisashi Iwakuma | Jered Weaver | Tom Wilhelmsen | |
| 2012-09-03 | Mon | OAK | AL | A | D | 135 | W | 8-3 | 9 | box - pbp - pit | W1 | 74-61 | 1 | 4 | 7 | 3:24 | 20,180 | C.J. Wilson | Tommy Milone (L) | C.J. Wilson | Tom Milone | None | |
| 2012-09-04 | Tue | OAK | AL | A | N | 136 | W | 6-1 | 9 | box - pbp - pit | W2 | 75-61 | 1 | 2 | 5 | 2:52 | 11,688 | Zack Greinke | Jarrod Parker (R) | Zack Greinke | Jarrod Parker | None | |
| 2012-09-04 | Tue | OAK | AL | A | N | 136 | W | 6-1 | 9 | box - pbp - pit | W3 | 75-61 | 1 | 2 | 5 | 2:52 | 11,688 | Zack Greinke | Kyle Parker (R) | Zack Greinke | Jarrod Parker | None | |
| 2012-09-05 | Wed | OAK | AL | A | D | 137 | W | 7-1 | 9 | box - pbp - pit | W4 | 76-61 | 1 | 2 | 5 | 3:10 | 15,404 | Dan Haren | Brandon McCarthy (R) | Dan Haren | Brandon McCarthy | None | |
| 2012-09-07 | Fri | DET | AL | H | N | 138 | W | 3-2 | 9 | box - pbp - pit | W5 | 77-61 | 1 | 2 | 6 | 2:49 | 40,104 | Ervin Santana | Max Scherzer (R) | Ernesto Frieri | Octavio Dotel | None | |
| 2012-09-08 | Sat | DET | AL | H | N | 139 | W | 6-1 | 9 | box - pbp - pit | W6 | 78-61 | 1 | 2 | 5 | 2:37 | 41,154 | C.J. Wilson | Justin Verlander (R) | C.J. Wilson | Justin Verlander | None | |
| 2012-09-09 | Sun | DET | AL | H | D | 140 | W | 3-2 | 9 | box - pbp - pit | W7 | 79-61 | 1 | 2 | 5 | 2:45 | 38,216 | Zack Greinke | Anibal Sanchez (R) | Zack Greinke | Anibal Sanchez | Ernesto Frieri | |
| 2012-09-10 | Mon | OAK | AL | H | N | 141 | L | 1-3 | 9 | box - pbp - pit | L1 | 79-62 | 1 | 2 | 5 | 2:25 | 36,064 | Dan Haren | Jarrod Parker (R) | Jarrod Parker | Dan Haren | Grant Balfour | |
| 2012-09-10 | Mon | OAK | AL | H | N | 141 | L | 1-3 | 9 | box - pbp - pit | L2 | 79-62 | 1 | 2 | 5 | 2:25 | 36,064 | Dan Haren | Kyle Parker (R) | Jarrod Parker | Dan Haren | Grant Balfour | |
| 2012-09-11 | Tue | OAK | AL | H | N | 142 | L | 5-6 | 9 | box - pbp - pit | L3 | 79-63 | 1 | 2 | 5 | 3:15 | 37,794 | Jerome Williams | Dan Straily (R) | Dan Straily | Jerome Williams | Jerry Blevins | |
| 2012-09-12 | Wed | OAK | AL | H | N | 143 | L | 1-4 | 9 | box - pbp - pit | L4 | 79-64 | 2 | 3 | 6 | 2:51 | 38,097 | Ervin Santana | A.J. Griffin (R) | A.J. Griffin | Ervin Santana | Ryan Cook | |
| 2012-09-13 | Thu | OAK | AL | H | D | 144 | W | 6-0 | 9 | box - pbp - pit | W1 | 80-64 | 1 | 2 | 5 | 2:30 | 38,029 | Jered Weaver | Brett Anderson (L) | Jered Weaver | Brett Anderson | None | |
| 2012-09-14 | Fri | KCA | AL | A | N | 145 | W | 9-7 | 9 | box - pbp - pit | W2 | 81-64 | 1 | 2 | 5 | 3:42 | 27,586 | C.J. Wilson | Bruce Chen (L) | Jordan Walden | Tim Collins | Ernesto Frieri | |
| 2012-09-15 | Sat | KCA | AL | A | N | 146 | L | 2-3 | 9 | box - pbp - pit | L1 | 81-65 | 2 | 3 | 6 | 2:23 | 23,027 | Zack Greinke | Jeremy Guthrie (R) | Kelvin Herrera | Ernesto Frieri | None | |
| 2012-09-16 | Sun | KCA | AL | A | D | 147 | W | 4-3 | 9 | box - pbp - pit | W1 | 82-65 | 1 | 2 | 5 | 2:43 | 24,979 | Dan Haren | Will Smith (L) | Dan Haren | Will Smith | Kevin Jepsen | |
| 2012-09-18 | Tue | TEX | AL | H | N | 148 | L | 11-3 | 9 | box - pbp - pit | L1 | 82-66 | 2 | 5 | 8 | 3:08 | 36,948 | Jered Weaver | Ryan Dempster (R) | Jered Weaver | Ryan Dempster | None | |
| 2012-09-19 | Wed | TEX | AL | H | N | 149 | L | 2-6 | 9 | box - pbp - pit | L2 | 82-67 | 2 | 5 | 8 | 3:03 | 37,093 | C.J. Wilson | Derek Holland (L) | Derek Holland | C.J. Wilson | None | |
| 2012-09-20 | Thu | TEX | AL | H | N | 150 | L | 1-3 | 9 | box - pbp - pit | L3 | 82-68 | 2 | 5 | 8 | 2:39 | 38,205 | Zack Greinke | Yu Darvish (R) | Yu Darvish | Ernesto Frieri | Joe Nathan | |
| 2012-09-21 | Fri | CHA | AL | H | N | 151 | W | 6-2 | 9 | box - pbp - pit | W1 | 83-68 | 1 | 3 | 6 | 2:32 | 39,326 | Ervin Santana | Jake Peavy (R) | Ervin Santana | Jake Peavy | None | |
| 2012-09-22 | Sat | CHA | AL | H | N | 152 | W | 4-2 | 9 | box - pbp - pit | W2 | 84-68 | 1 | 3 | 6 | 2:48 | 41,440 | Dan Haren | Jose Quintana (L) | Dan Haren | Jose Quintana | Ernesto Frieri | |
| 2012-09-23 | Sun | CHA | AL | H | D | 153 | W | 4-1 | 9 | box - pbp - pit | W3 | 85-68 | 1 | 2 | 5 | 2:39 | 36,546 | Jered Weaver | Gavin Floyd (R) | Jered Weaver | Gavin Floyd | None | |
| 2012-09-25 | Tue | SEA | AL | H | N | 154 | W | 5-4 | 9 | box - pbp - pit | W4 | 86-68 | 1 | 2 | 5 | 3:10 | 38,538 | Zack Greinke | Erasmo Ramirez (R) | Zack Greinke | Erasmo Ramirez | Ernesto Frieri | |
| 2012-09-26 | Wed | SEA | AL | H | N | 155 | W | 4-3 | 9 | box - pbp - pit | W5 | 87-68 | 1 | 2 | 5 | 3:03 | 37,916 | C.J. Wilson | Felix Hernandez (R) | Ernesto Frieri | Stephen Pryor | None | |
| 2012-09-27 | Thu | SEA | AL | H | D | 156 | L | 4-9 | 9 | box - pbp - pit | L1 | 87-69 | 1 | 2 | 5 | 3:27 | 37,377 | Dan Haren | Hisashi Iwakuma (R) | Hisashi Iwakuma | Dan Haren | None | |
| 2012-09-28 | Fri | TEX | AL | A | N | 157 | W | 7-4 | 9 | box - pbp - pit | W1 | 88-69 | 1 | 2 | 5 | 3:14 | 46,662 | Jered Weaver | Ryan Dempster (R) | Jered Weaver | Ryan Dempster | Ernesto Frieri | |
| 2012-09-30 | Sun | TEX | AL | A | D | 158 | W | 5-4 | 9 | box - pbp - pit | W2 | 89-70 | 1 | 2 | 6 | 3:12 | 46,713 | Zack Greinke | Yu Darvish (R) | Garrett Richards | Joe Nathan | Ernesto Frieri | |
| 2012-09-30 | Sun | TEX | AL | A | N | 159 | L | 7-8 | 9 | box - pbp - pit | L1 | 89-70 | 1 | 2 | 6 | 3:17 | 48,089 | Ervin Santana | Derek Holland (L) | Derek Holland | Ervin Santana | Joe Nathan | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2012-10-01 | Mon | SEA | AL | A | N | 160 | W | 8-4 | 9 | box - pbp - pit | W1 | 90-70 | 1 | 2 | 6 | 3:19 | 13,963 | C.J. Wilson | Felix Hernandez (R) | C.J. Wilson | Felix Hernandez | None | |
| 2012-10-02 | Tue | SEA | AL | A | N | 161 | L | 1-6 | 9 | box - pbp - pit | L1 | 90-71 | 2 | 3 | 6 | 2:49 | 14,353 | Dan Haren | Hisashi Iwakuma (R) | Hisashi Iwakuma | Dan Haren | None | |
| 2012-10-03 | Wed | SEA | AL | A | D | 162 | L | 0-12 | 9 | box - pbp - pit | L2 | 90-72 | 2 | 4 | 7 | 2:56 | 15,614 | Jered Weaver | Blake Beavan (R) | Blake Beavan | Jered Weaver | None |
Team Splits | Top |
| Category | GP | W | L | Wpct | RF | RA | Diff |
| Season Total | 166 | 93 | 73 | .560 | 781 | 704 | +77 |
| Home Games | 82 | 44 | 38 | .537 | 349 | 312 | +37 |
| Away Games | 84 | 49 | 35 | .583 | 432 | 392 | +40 |
| Night Games | 115 | 69 | 46 | .600 | 574 | 482 | +92 |
| Day Games | 51 | 24 | 27 | .471 | 207 | 222 | -15 |
| March/April | 23 | 10 | 13 | .435 | 80 | 94 | -14 |
| May | 30 | 21 | 9 | .700 | 122 | 98 | +24 |
| June | 26 | 15 | 11 | .577 | 138 | 106 | +32 |
| July | 26 | 11 | 15 | .423 | 138 | 119 | +19 |
| August | 29 | 17 | 12 | .586 | 160 | 172 | -12 |
| Sept/Oct | 32 | 19 | 13 | .594 | 143 | 115 | +28 |
| 1-Run Games | 36 | 19 | 17 | .528 | 158 | 158 | 0 |
| Close Games (1-2-3 Runs) | 92 | 49 | 43 | .533 | 398 | 381 | +17 |
| Blowouts (7+ runs) | 16 | 9 | 7 | .563 | 111 | 107 | +4 |
| Extra Innings | 8 | 4 | 4 | .500 | 46 | 45 | +1 |
| Shutouts | 30 | 17 | 13 | .567 | 85 | 68 | +17 |
| vs LHSP | 49 | 24 | 25 | .490 | 232 | 201 | +31 |
| vs RHSP | 117 | 69 | 48 | .590 | 549 | 503 | +46 |
| vs Division | 61 | 35 | 26 | .574 | 283 | 264 | +19 |
| vs League | 148 | 84 | 64 | .568 | 696 | 647 | +49 |
| InterLeague | 18 | 9 | 9 | .500 | 85 | 57 | +28 |
