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| | 1 | 23 | Jacoby Ellsbury | $$ | of | 21 | 9/11/1983 | 6-1 | 185 | L | L | MLB | 2007-2007 | Oregon State University |
| | 1 | 26 | Craig Hansen | $$ | rhp | 21 | 11/15/1983 | 6-6 | 210 | R | R | MLB | 2005-2006 | St. John's University |
| | 1 | 42 | Clay Buchholz | $$ | rhp | 20 | 8/14/1984 | 6-3 | 190 | L | R | MLB | 2007-2007 | Angelina College |
| | 1 | 45 | Jed Lowrie | $$ | 2b | 21 | 4/17/1984 | 6-0 | 180 | B | R | AAA | | Stanford University |
| | 1 | 47 | Michael Bowden | $$ | rhp | 18 | 9/9/1986 | 6-3 | 215 | R | R | AA | | Waubonsie Valley High School (Aurora,IL) |
| | 2 | 57 | Jon Egan | $$ | c | 18 | 10/12/1986 | 6-4 | 210 | R | R | AA | | Cross Creek High School (Augusta,GA) |
| | 4 | 138 | William Blue | | rhp | 18 | 4/5/1987 | 6-2 | 215 | R | R | Rookie | | Morro Bay High School (Morro Bay,CA) |
| | 5 | 168 | Reid Engel | | of | 18 | 5/7/1987 | 6-2 | 175 | L | R | AA | | Lewis-Palmer High School (Monument,CO) |
| | 6 | 198 | Jeff Corsaletti | | of | 22 | 2/22/1983 | 6-0 | 190 | L | R | AA | | University of Florida |
| | 7 | 228 | Yahmed Yema | | OF | 20 | 9/3/1984 | 6-0 | 182 | L | L | AA | | Florida International University |
| | 8 | 258 | JT Zink | | RHP | 20 | 5/6/1985 | 6-2 | 195 | R | R | AA | | Everett Community College (WA) |
| | 9 | 288 | Mark Wagner | | c | 21 | 6/11/1984 | 6-1 | 205 | R | R | AA | | University of California-Irvine |
| | 10 | 318 | Kevin Guyette | | RHP | 22 | 12/3/1982 | 6-3 | 205 | R | R | AAA | | University of Arizona |
| | 11 | 348 | Ismael Casillas | | rhp | 22 | 12/8/1982 | 6-3 | 0 | R | R | AA | | Benedictine College (Kan.) |
| | 12 | 378 | Kyle Fernandes | | lhp | 19 | 9/12/1985 | 6-0 | 185 | L | L | AA | | Massasoit High School (Massasoit,MA) |
| | 13 | 408 | Jay Johnson | | of | 22 | 12/19/1982 | 6-2 | 185 | R | R | AA | | Xavier University |
| | 14 | 438 | Pedro Alvarez | | SS | 18 | 2/6/1987 | 6-2 | 205 | L | R | College | | Horace Mann High School (Bronx,NY) |
| | 15 | 468** | Patrick Thomas | | RHP | 18 | 9/29/1986 | 6-3 | 190 | R | R | College | | Jeffersonville High School (Jeffersonville,IN) |
| | 16 | 498 | Matt Mercurio | | 3b | 22 | 11/26/1982 | 6-2 | 180 | R | R | AA | | Florida Southern College |
| | 17 | 528 | Dominic Ramos | | SS | 22 | 3/10/1983 | 5-10 | 180 | R | R | AA | | Texas State University |
| | 18 | 558 | Nick Criaris | | c | 18 | 6/16/1987 | 6-2 | 220 | L | R | - | | |
| | 19 | 588 | Jim Baxter | | lhp | 21 | 8/8/1983 | 6-0 | 195 | L | L | A- | | Villanova University |
| | 20 | 618 | Charles Blackmon | | lhp | | | | | | | College | | Young Harris College |
| | 21 | 648 | Solomon Johnson | | RHP | | | | 0 | | | - | | Navarro College |
| | 22 | 678 | Orvil Aviles | | lhp | 17 | 11/5/1987 | 6-4 | 0 | L | L | - | | Fernando Callejo High School (Manati,PR) |
| | 23 | 708 | Carl Lipsey | | 2b | 22 | 6/5/1983 | 5-10 | 175 | R | R | A- | | Jackson State University |
| | 24 | 738 | Jason Twomley | | OF | 22 | 9/20/1982 | 6-0 | 215 | L | L | AA | | University of Massachusetts |
| | 25 | 768 | Ricardo Sanchez | | c | 22 | 9/6/1982 | 5-11 | 215 | R | R | A- | | Barry University |
| | 26 | 798 | Kirby Yates | | RHP | 18 | 3/25/1987 | 5-10 | 170 | L | R | - | | Kauai High School (Lihue,HI) |
| | 27 | 828 | Matt Hancock | | lhp | 22 | 10/1/1982 | 6-3 | 195 | L | L | AA | | Oral Roberts University |
| | 28 | 858 | Ryan Hinson | | lhp | 18 | 5/12/1987 | 6-3 | 220 | L | L | College | | Northwestern High School (Rock Hill,SC) |
| | 29 | 888 | Chris Jones | | RHP | 21 | 6/9/1984 | 6-3 | 205 | R | R | AA | | Indiana State University |
| | 30 | 918 | Ryan Colvin | | rhp | 18 | 4/12/1987 | 6-2 | 170 | R | R | AA | | Carroll High School (Corpus Christi,TX) |
| | 31 | 948 | Luis Exposito | | c | 18 | 1/20/1987 | 6-3 | 210 | R | R | AA | | Champagnat Catholic High School (Hialeah,FL) |
| | 32 | 978 | Jeff Natale | | 2B | 22 | 8/24/1982 | 5-9 | 170 | R | R | AA | | Trinity College (Connecticut) |
| | 33 | 1008** | John Hester | | c | 21 | 9/14/1983 | 6-4 | 210 | R | R | A+ | | Stanford University |
| | 34 | 1038 | Allan Dykstra | | 1B | 18 | 5/21/1987 | 6-6 | 212 | L | R | College | | Rancho Bernardo High School (San Diego,CA) |
| | 35 | 1068 | Jason Determann | | lhp | | | | | | | College | | Louisiana State University |
| | 36 | 1098 | Mark McClure | | rhp | 18 | 6/24/1987 | 6-8 | 205 | R | R | - | | Hillsborough High School (Tampa,FL) |
| | 37 | 1128 | Jason Schnitzer | | RHP | 18 | 9/8/1986 | 6-2 | 185 | R | R | - | | Los Alamitos High School (Los Alamitos,CA) |
| | 38 | 1158 | Levi Tapia | | c | 18 | 4/21/1987 | 5-10 | 200 | R | R | Rookie | | Ralston Valley High School (Arvada,CO) |
| | 39 | 1187 | Bubba Bell | | of | 22 | 10/9/1982 | 6-0 | 195 | L | R | AA | | Nicholls State University |
| | 40 | 1216 | Blake Maxwell | | RHP | 20 | 8/1/1984 | 6-5 | 255 | R | R | AA | | Methodist College |
| | 41 | 1245** | Eddie Degerman | | rhp | 21 | 9/14/1983 | 6-4 | 205 | R | R | A+ | | Rice University |
| | 42 | 1274 | Miguel Alicea | | OF | 18 | 1/2/1987 | 6-0 | 0 | R | R | AAA | | Manuela Toro (Caguas,PR) |
| | 43 | 1303 | Jason Castro | | c | 18 | 6/18/1987 | 6-3 | 195 | L | R | College | | Castro Valley High School (Castro Valley,CA) |
| | 44 | 1332 | Chris Garcia | | 1b | 17 | 11/25/1987 | 6-1 | 214 | L | R | Rookie | | Xavieran High School (Brooklyn,NY) |
| | 45 | 1361 | Dustin Bamberg | | C | | | | | | | College | | Tallahassee Community College |
| | 46 | 1390 | Terry Large | | RHP | 22 | 5/28/1983 | 6-4 | 185 | R | R | AAA | | University of Alabama |
| | 47 | 1418 | Alex Wolfe | | c | 18 | 4/9/1987 | 6-0 | 215 | L | R | - | | Timpanogos High School (Orem,UT) |
| | 48 | 1446 | Matt Sheely | | of | 18 | 8/30/1986 | 5-7 | 165 | R | R | AAA | | Palm Beach Gardens High School (Palm Beach Gardens,FL) |
| | 49 | 1473 | Erik Turgeon | | rhp | 18 | 3/25/1987 | 6-0 | 170 | R | R | College | | Dunedin High School (Dunedin,FL) |
| | 50 | 1500 | Colin Arnold | | OF | 17 | 8/16/1987 | 6-2 | 185 | L | L | - | | Kings Academy High School (West Palm Beach,FL) |
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