| Northern | ||||||||||||||
| Rk | Team | Affiliate | W | L | Pct | Gbl | RF | RA | Manager | Stadium | Attendance | Top Batter | Top Pitcher | Playoffs |
| 1 | Frederick Keys ** | BAL | 80 | 59 | .576 | -- | 569 | 488 | Orlando Gomez | Harry Grove Stadium | 296,296 | Steve Bumbry (15) | Nathan Moreau (3) | League Champions |
| 2 | Potomac Nationals | WAN | 68 | 71 | .489 | 12.0 | 583 | 627 | Matt LeCroy | G. Richard Pfitzner Stadi | 171,096 | Destin Hood (5) | Paul Demny (2) | Lost in Semi-Finals |
| 3 | Wilmington Blue Rocks | KC | 66 | 72 | .478 | 13.5 | 528 | 592 | Brian Rupp | Daniel S. Frawley Stadium | 288,738 | Johnny Whittleman (9) | Justin Marks (1) | |
| 4 | Lynchburg Hillcats | ATL | 60 | 78 | .435 | 19.5 | 579 | 601 | Luis Salazar | Calvin Falwell Field | 169,367 | Joey Terdoslavich (2) | Chris Masters (4) | |
| Southern | ||||||||||||||
| Rk | Team | Affiliate | W | L | Pct | Gbl | RF | RA | Manager | Stadium | Attendance | Top Batter | Top Pitcher | Playoffs |
| 1 | Kinston Indians | CLE | 76 | 62 | .551 | -- | 527 | 564 | Aaron Holbert | Grainger Stadium | 112,181 | Adam Abraham (8) | T.J. House (7) | Lost in Finals |
| 2 | Myrtle Beach Pelicans | TEX | 72 | 67 | .518 | 4.5 | 602 | 545 | Jason Wood | BB&T Coastal Field | 213,200 | Jared Prince (6) | Wilfredo Boscan (28) | Lost in Semi-Finals |
| 3 | Winston-Salem Dash | CHW | 69 | 71 | .493 | 8.0 | 644 | 614 | Julio Vinas | BB&T Ballpark | 312,416 | Ian Gac (1) | Cameron Bayne (5) | |
| 4 | Salem Red Sox | BOS | 64 | 75 | .460 | 12.5 | 620 | 621 | Bruce Crabbe | Lewis-Gale Field at Salem | 226,337 | Kolbrin Vitek (18) | Drake Britton (15) | |