| 2010-05-01 | BOS | 29.230 | L 9-12 | @ BAL | 1 | 74 | L | ST | 4.2 | 7 | 7 | 6 | 2 | 3 | 4 | 99 | 41 | 58 | 59% | 0-1 | 10.80 | 2.00 |
| 2010-05-06 | BOS | 29.235 | L 11-6 | vs ANA | 2 | 75 | W | ST | 5.1 | 5 | 5 | 5 | 0 | 3 | 3 | 92 | 34 | 58 | 63% | 1-1 | 9.90 | 1.80 |
| 2010-05-11 | BOS | 29.240 | L 6-1 | vs TOR | 3 | 76 | W | ST | 7.0 | 3 | 1 | 1 | 0 | 0 | 9 | 102 | 35 | 67 | 66% | 2-1 | 6.35 | 1.24 |
| 2010-05-17 | BOS | 29.246 | L 9-11 | @ NYA | 4 | 77 | - | ST | 4.2 | 9 | 7 | 7 | 0 | 3 | 3 | 105 | 43 | 62 | 59% | 2-1 | 7.77 | 1.50 |
| 2010-05-22 | BOS | 29.251 | W 5-0 | @ PHI | 5 | 78 | W | ST | 8.0 | 1 | 0 | 0 | 0 | 4 | 5 | 115 | 41 | 74 | 64% | 3-1 | 5.70 | 1.27 |
| 2010-05-27 | BOS | 29.256 | W 3-4 | vs KCA | 6 | 79 | L | ST | 4.2 | 2 | 3 | 3 | 0 | 8 | 1 | 112 | 52 | 60 | 54% | 3-2 | 5.82 | 1.41 |
| 2010-06-02 | BOS | 29.262 | L 6-4 | vs OAK | 7 | 80 | W | ST | 6.2 | 10 | 3 | 3 | 1 | 0 | 7 | 108 | 25 | 83 | 77% | 4-2 | 5.49 | 1.41 |
| 2010-06-07 | BOS | 29.267 | W 4-1 | @ CLE | 8 | 81 | W | ST | 8.0 | 4 | 0 | 0 | 0 | 2 | 5 | 113 | 43 | 70 | 62% | 5-2 | 4.59 | 1.31 |
| 2010-06-24 | BOS | 29.284 | W 13-11 | @ COL | 9 | 82 | - | ST | 5.0 | 5 | 2 | 2 | 0 | 4 | 6 | 106 | 44 | 62 | 58% | 5-2 | 4.50 | 1.35 |
| 2010-06-30 | BOS | 29.290 | W 4-9 | vs TBA | 10 | 83 | L | ST | 6.0 | 4 | 3 | 3 | 0 | 4 | 7 | 107 | 45 | 62 | 58% | 5-3 | 4.50 | 1.35 |
| 2010-07-05 | BOS | 29.295 | L 5-6 | @ TBA | 11 | 84 | - | ST | 5.0 | 8 | 5 | 4 | 0 | 4 | 4 | 118 | 52 | 66 | 56% | 5-3 | 4.71 | 1.43 |
| 2010-07-11 | BOS | 29.301 | W 3-2 | @ TOR | 12 | 85 | W | ST | 6.0 | 6 | 2 | 2 | 1 | 0 | 5 | 88 | 26 | 62 | 70% | 6-3 | 4.56 | 1.39 |
| 2010-07-19 | BOS | 29.309 | W 2-1 | @ OAK | 13 | 86 | W | ST | 6.2 | 2 | 1 | 1 | 1 | 2 | 6 | 89 | 27 | 62 | 70% | 7-3 | 4.27 | 1.32 |
| 2010-07-25 | BOS | 29.315 | L 2-4 | @ SEA | 14 | 87 | - | ST | 6.0 | 4 | 1 | 1 | 0 | 5 | 4 | 120 | 50 | 70 | 58% | 7-3 | 4.07 | 1.33 |
| 2010-07-31 | BOS | 29.321 | L 5-4 | vs DET | 15 | 88 | - | ST | 6.0 | 8 | 4 | 4 | 1 | 2 | 5 | 108 | 36 | 72 | 67% | 7-3 | 4.20 | 1.36 |
| 2010-08-05 | BOS | 29.326 | L 6-2 | vs CLE | 16 | 89 | W | ST | 8.0 | 5 | 1 | 1 | 1 | 2 | 6 | 105 | 35 | 70 | 67% | 8-3 | 3.95 | 1.32 |
| 2010-08-10 | BOS | 29.331 | W 7-5 | @ TOR | 17 | 90 | - | ST | 5.2 | 6 | 4 | 4 | 2 | 3 | 7 | 109 | 39 | 70 | 64% | 8-3 | 4.11 | 1.34 |
| 2010-08-15 | BOS | 29.336 | L 3-7 | @ TEX | 18 | 91 | L | ST | 6.2 | 7 | 4 | 4 | 0 | 2 | 8 | 119 | 44 | 75 | 63% | 8-4 | 4.17 | 1.34 |
| 2010-08-21 | BOS | 29.342 | L 5-4 | vs TOR | 19 | 92 | - | ST | 8.0 | 6 | 4 | 4 | 1 | 3 | 8 | 108 | 36 | 72 | 67% | 8-4 | 4.19 | 1.32 |
| 2010-09-02 | BOS | 29.354 | W 6-4 | @ BAL | 20 | 93 | W | ST | 5.2 | 6 | 4 | 4 | 0 | 1 | 6 | 91 | 36 | 55 | 60% | 9-4 | 4.28 | 1.31 |
| 2010-09-07 | BOS | 29.359 | W 5-14 | vs TBA | 21 | 94 | L | ST | 4.2 | 8 | 8 | 8 | 2 | 4 | 4 | 88 | 36 | 52 | 59% | 9-5 | 4.71 | 1.37 |
| 2010-09-14 | BOS | 30.001 | W 9-6 | @ SEA | 22 | 95 | - | ST | 6.0 | 8 | 5 | 5 | 0 | 4 | 3 | 119 | 51 | 68 | 57% | 9-5 | 4.84 | 1.40 |
| 2010-09-20 | BOS | 30.007 | W 2-4 | vs BAL | 23 | 96 | L | ST | 6.1 | 6 | 4 | 4 | 0 | 5 | 4 | 107 | 38 | 69 | 64% | 9-6 | 4.85 | 1.40 |
| 2010-09-26 | BOS | 30.013 | L 3-4 | @ NYA | 24 | 97 | - | ST | 8.0 | 4 | 2 | 2 | 1 | 1 | 7 | 110 | 41 | 69 | 63% | 9-6 | 4.71 | 1.36 |
| 2010-10-02 | BOS | 30.019 | L 7-6 | vs NYA | 25 | 98 | - | ST | 5.0 | 3 | 4 | 2 | 0 | 5 | 6 | 100 | 47 | 53 | 53% | 9-6 | 4.68 | 1.37 |