| Pitcher | Career Wins | Teams | 300th Win Date |
| Cy Young | 511 | Cle (NL), Bos (AL), StL (NL), Bos (NL), Cle (AL), Bos (NL) | 1901-07-03 |
| Walter Johnson | 417 | Was (AL) | 1920-05-14 |
| Christy Mathewson | 373 | NY (NL), Cin | 1912-06-28 |
| Grover Cleveland Alexander | 373 | Phi (NL), Chi (NL), StL (NL) | 1924-09-20 |
| Warren Spahn | 363 | Bos/Mil, NY (NL), SF | 1961-08-11 |
| Pud Galvin | 361 | Buf, Pit (Amer. Assoc.), Pit (NL), Pit (Players League), StL (NL) | 1888-06-04 |
| Kid Nichols | 361 | Bos, StL, Phi (NL) | 1900-09-07 |
| Roger Clemens active | 351 | Bos, Tor, NY (AL), Hou (NL), NY (AL) | 2003-06-13 |
| Tim Keefe | 342 | Troy, NY (Amer. Assoc.), NY (NL), Phi | 1890-06-04 |
| Greg Maddux† active | 340 | Chi (NL), Atl, Chi (NL), LA (NL), SD | 2004-08-07 |
| Steve Carlton | 329 | StL (NL), Phi, SF, Chi (AL), Cle, Min | 1983-09-23 |
| John Clarkson | 328 | Worc, Chi (NL), Bos (NL), Cle (NL) | 1892-09-21 |
| Eddie Plank | 326 | Phi (AL), StL (Fed. League), StL (AL) | 1915-09-11 |
| Don Sutton | 324 | LA (NL), Hou, Mil, Oak (AL), Cal | 1986-06-18 |
| Nolan Ryan | 324 | NY (NL), Cal (AL), Hou (NL), Tex(AL) | 1990-07-31 |
| Phil Niekro | 318 | Mil/Atl (NL), NY (AL), Cle, Tor | 1985-10-06 |
| Gaylord Perry | 314 | SF, Cle, Tex, SD, NY (AL), Atl, Sea, KC | 1982-05-06 |
| Tom Seaver | 311 | NY (NL), Cin, Chi (AL), Bos | 1985-08-04 |
| Charles Radbourn | 310 | Prov, Bos (NL), Bos (Players League), Cin | 1891-05-14 |
| Mickey Welch | 307 | Troy, NY (NL) | 1890-08-11 |
| Tom Glavine† active | 300 | Atl, NY (NL) | 2007-08-05 |
| Lefty Grove | 300 | Phi (AL), Bos (AL) | 1941-07-25 |
| Early Wynn | 300 | Was, Cle, Chi (AL) | 1963-07-13 |
| |