| Rnd | Ovl | Phase | Player Name | $$ | Pos | Age | Born | Ht | Wt | B | T | High Level | MLB Years | Drafted From |
| 1 | 7 | June-Reg | Homer Bailey | $$ | P | 18 | 5/3/1986 | 6-4 | 185 | R | R | MLB | 2007-2008 | La Grange High School (La Grange,TX) |
| 2 | 48 | June-Reg | B.J. Szymanski | $$ | OF | 21 | 10/1/1982 | 6-5 | 210 | B | R | AAA | | Princeton University |
| 3 | 78 | June-Reg | Craig Tatum | $$ | C | 21 | 3/18/1983 | 6-1 | 215 | R | R | AA | | Mississippi State University |
| 4 | 108 | June-Reg | Rafael Gonzalez | | P | 18 | 3/21/1986 | 6-1 | 225 | R | R | A | | |
| 5 | 138 | June-Reg | Paul Janish | | SS | 21 | 10/12/1982 | 6-2 | 180 | R | R | MLB | 2008-2008 | Rice University |
| 6 | 168 | June-Reg | Lonny Roa | | C | 18 | 11/28/1985 | 6-3 | 215 | R | R | Rookie | | Puerto Rico Baseball Academy High School (Gurabo,PR) |
| 7 | 198 | June-Reg | Philippe Valiquette | | P | 17 | 2/14/1987 | 6-0 | 175 | L | L | A+ | | Edouard Montpetit High School (Montreal,QC) |
| 8 | 228 | June-Reg | Greg Goetz | | P | 20 | 1/25/1984 | 6-4 | 195 | L | L | Rookie | | Bellevue Community College (WA) |
| 9 | 258 | June-Reg | Trevor Lawhorn | | 2B | 21 | 12/18/1982 | 6-2 | 182 | R | R | A+ | | East Carolina University |
| 10 | 288 | June-Reg | Terrell Young | | P | 18 | 8/7/1985 | 6-3 | 175 | R | R | A+ | | Grenada High School (Grenada,MS) |
| 11 | 318 | June-Reg | Jason Urquidez | | P | 21 | 9/12/1982 | 6-2 | 175 | R | R | A+ | | Arizona State University |
| 12 | 348 | June-Reg | Cody Strait | | OF | 21 | 5/28/1983 | 6-1 | 185 | R | R | AAA | | University of Evansville |
| 13 | 378 | June-Reg | Drew Anderson | | 2B | 21 | 2/2/1983 | 5-9 | 175 | B | R | AAA | | Ohio State University |
| 14 | 408 | June-Reg | Jared Sanders | | P | 22 | 11/19/1981 | 6-2 | 210 | R | R | A | | Oregon State University |
| 15 | 438 | June-Reg | Jarrett Reininger | | 3B | 21 | 12/3/1982 | 5-10 | 190 | R | R | A | | University of Texas |
| 16 | 468 | June-Reg | Travis Kaats | | OF | 22 | 4/27/1982 | 6-1 | 205 | R | R | Rookie | | |
| 17 | 498** | June-Reg | Milton Loo | | SS | 18 | 4/2/1986 | 6-1 | 185 | R | R | Rookie | | Molokai High School (Hoolehua,HI) |
| 18 | 528 | June-Reg | Charles O'Neal | | P | 20 | 9/12/1983 | 6-4 | 165 | R | L | A+ | | Chipola College |
| 19 | 558 | June-Reg | Andrew Jenson | | P | 22 | 12/31/1981 | 6-2 | 200 | L | L | Rookie | | San Diego State University |
| 20 | 588 | June-Reg | Robert Coello | | C | 19 | 11/23/1984 | 6-4 | 215 | R | R | Rookie | | Okaloosa-Walton College |
| 21 | 618 | June-Reg | Blake Honey | | SS | 18 | 12/24/1985 | 6-1 | 175 | R | R | Rookie | | |
| 22 | 648 | June-Reg | Matt Levering | | 3B | 22 | 12/18/1981 | 6-0 | 195 | R | R | Rookie | | Regis University (Colorado) |
| 23 | 678 | June-Reg | Pedro Hawkins | | OF | 20 | 11/30/1983 | 5-10 | 195 | R | R | Rookie | | Green River Community College |
| 24 | 708 | June-Reg | Adam Gillihan | | P | 20 | 9/28/1983 | 6-3 | 200 | R | R | Rookie | | Crowder College |
| 25 | 738** | June-Reg | Robbie Nickols | | P | 18 | 3/4/1986 | 6-5 | 215 | B | L | Rookie | | Sabino High School (Tucson,AZ) |
| 26 | 768 | June-Reg | Johnny Dillard | | P | 23 | 1/14/1981 | 6-1 | 160 | R | R | Ind | | Southwestern Oklahoma State University |
| 27 | 798 | June-Reg | James Langham | | OF | 21 | 9/3/1982 | 6-0 | 205 | R | R | Rookie | | Georgia College & State University |
| 28 | 828 | June-Reg | Donnie Ecker | | OF | 18 | 3/9/1986 | 6-4 | 190 | L | R | Rookie | | Los Altos High School (Los Altos,CA) |
| 29 | 858 | June-Reg | Terrance Sparks | | P | 21 | 2/19/1983 | 6-0 | 170 | L | L | Rookie | | Prairie View A&M University |
| 30 | 888 | June-Reg | David Griffin | | P | 22 | 8/16/1981 | 6-0 | 180 | L | L | A+ | | Fresno State University |
| 31 | 918** | June-Reg | Jacob Arrieta | | P | 18 | 3/6/1986 | 6-4 | 225 | R | R | A+ | | Plano East High School (Plano,TX) |
| 32 | 948 | June-Reg | Robert Wachman | | P | 22 | 4/10/1982 | 6-4 | 205 | R | R | A | | Valdosta State University |
| 33 | 978 | June-Reg | Dylan Moseley | | P | 18 | 6/18/1986 | 6-4 | 185 | R | R | College | | Arkansas High School (Texarkana,AR) |
| 34 | 1008 | June-Reg | Drew Phillips | | SS | 23 | 4/12/1981 | 6-2 | 195 | R | R | Rookie | | Northwestern Oklahoma State University |
| 35 | 1038 | June-Reg | Robert Palencia | | P | | | | | | | - | | Monsignor Pace High School (Miami,FL) |
| 36 | 1068 | June-Reg | T.J. Johnson | | P | | | | | | | College | | Central Michigan University |
| 37 | 1098 | June-Reg | Andrew Wells | | OF | | | | | | | - | | Union High School (Tulsa,OK) |
| 38 | 1128 | June-Reg | Rob Orton | | C | | | | | | | College | | Florida Atlantic University |
| 39 | 1158 | June-Reg | Mario Colletto | | 1B | 18 | 4/20/1986 | 6-3 | 185 | L | L | - | | Simi Valley High School (Simi Valley,CA) |
| 40 | 1188 | June-Reg | Brad Morenko | | P | 22 | 8/15/1981 | 6-4 | 215 | R | R | A+ | | Oakland University |
| 41 | 1218** | June-Reg | Scott Mueller | | P | 18 | 6/9/1986 | 6-4 | 200 | R | R | A+ | | Greenway High School (Phoenix,AZ) |
| 42 | 1247 | June-Reg | Ben Price | | SS | | | | | | | College | | Terra Linda High School (San Rafael,CA) |
| 43 | 1276 | June-Reg | Ben Parker | | P | | | | | | | - | | Huston-Tillotson University |
| 44 | 1305** | June-Reg | Jacob Long | | C | | | 6-2 | 215 | R | R | A+ | | Johansen High School (Modesto,CA) |
| 45 | 1334 | June-Reg | J.D. Roberts | | OF | 22 | 8/8/1981 | 6-4 | 215 | L | R | A+ | | University of Michigan |
| 46 | 1363 | June-Reg | Justin Glover | | 1B | | | | | | | - | | Westside High School (Houston,TX) |
| 47 | 1392 | June-Reg | Bradley Jarrell | | 1B | | | | | | | - | | Denham Springs High School (Denham Springs,LA) |
| 48 | 1421 | June-Reg | Bradley Key | | 3B | 21 | 3/14/1983 | 6-0 | 185 | R | R | A+ | | University of South Carolina at Aiken |
| 49 | 1449 | June-Reg | Tyler Cales | | P | | | | | | | College | | James Madison High School (San Antonio,TX) |
| 50 | 1477 | June-Reg | Juan Buck | | OF | 19 | 1/26/1985 | 6-3 | 214 | R | R | Rookie | | East High School (Anchorage,AK) |
| |
