| Rnd | Ovl | Phase | Player Name | $$ | Pos | Age | Born | Ht | Wt | B | T | High Level | MLB Years | Drafted From |
| 1 | 4** | June-Reg | Jeff Niemann | | P | 21 | 2/28/1983 | 6-9 | 260 | R | R | MLB | 2008-2008 | Rice University |
| 2 | 45 | June-Reg | Reid Brignac | $$ | SS | 18 | 1/16/1986 | 6-3 | 170 | L | R | AAA | | St. Amant High School (St. Amant,LA) |
| 3 | 75 | June-Reg | Wade Davis | $$ | P | 18 | 9/7/1985 | 6-5 | 220 | R | R | AA | | Lake Wales High School (Lake Wales,FL) |
| 4 | 105 | June-Reg | Matt Spring | | C | 19 | 11/7/1984 | 6-2 | 215 | R | R | AA | | Dixie State College of Utah |
| 5 | 135 | June-Reg | Jacob McGee | | P | 17 | 8/6/1986 | 6-3 | 190 | L | L | AA | | Reed High School (Sparks,NV) |
| 6 | 165 | June-Reg | Ryan Royster | | OF | 17 | 7/25/1986 | 6-2 | 205 | R | R | A+ | | Churchill High School (Eugene,OR) |
| 7 | 195 | June-Reg | Fernando Perez | | OF | 21 | 4/28/1983 | 6-1 | 195 | R | R | AAA | | Columbia University |
| 8 | 225 | June-Reg | Rhyne Hughes | | 1B | 20 | 9/9/1983 | 6-2 | 175 | L | L | AA | | Pearl River Community College |
| 9 | 255 | June-Reg | Joseph Muro | | P | 20 | 2/16/1984 | 6-0 | 161 | R | R | A- | | Mount San Antonio College |
| 10 | 285 | June-Reg | Matt Walker | | P | 17 | 8/16/1986 | 6-3 | 193 | R | R | A+ | | Central High School (Baton Rouge,LA) |
| 11 | 315 | June-Reg | Josh Asanovich | | 2B | 21 | 1/31/1983 | 6-0 | 190 | R | R | AA | | Arizona State University |
| 12 | 345 | June-Reg | Chris Cunningham | | OF | 21 | 8/24/1982 | 6-0 | 200 | R | R | A+ | | South Suburban College |
| 13 | 375 | June-Reg | Andy Sonnanstine | | P | 21 | 3/18/1983 | 6-3 | 185 | L | R | MLB | 2007-2008 | Kent State University |
| 14 | 405 | June-Reg | Woods Fines | | P | 18 | 8/14/1985 | 6-5 | 190 | R | R | A | | Northwood High School (Pittsboro,NC) |
| 15 | 435 | June-Reg | Kenneth Brock | | P | 21 | 1/3/1983 | 6-1 | 220 | L | L | Rookie | | Lane College |
| 16 | 465 | June-Reg | Cale Iorg | | SS | | | | | | | College | | Karns High School (Knoxville,TN) |
| 17 | 495 | June-Reg | Marcus Barriger | | P | 21 | 8/5/1982 | 6-1 | 215 | R | R | A- | | Armstrong Atlantic State University |
| 18 | 525 | June-Reg | James Scholzen | | SS | | | | | | | Rookie | | Hurricane High School (Hurricane,UT) |
| 19 | 555 | June-Reg | Chris Nowak | | 3B | 21 | 2/21/1983 | 6-5 | 225 | R | R | AA | | University of South Carolina-Spartanburg |
| 20 | 585** | June-Reg | Matt Duryea | | P | | | | | | | - | | Marshfield High School (Coos Bay,OR) |
| 21 | 615 | June-Reg | Patrick Breen | | OF | 22 | 6/23/1982 | 6-3 | 210 | L | L | AA | | University of Houston |
| 22 | 645 | June-Reg | Ryan Bitter | | P | 22 | 9/30/1981 | 6-1 | 195 | R | R | A | | Siena College |
| 23 | 675 | June-Reg | Logan Wiens | | 1B | 18 | 1/13/1986 | 6-6 | 210 | R | R | A | | Merced High School (Merced,CA) |
| 24 | 705 | June-Reg | Francisco Leandro | | OF | 23 | 7/19/1980 | 5-10 | 180 | L | L | AA | | Central Missouri State University |
| 25 | 735** | June-Reg | Deunte Heath | | P | 18 | 8/28/1985 | 6-4 | 205 | R | R | A+ | | Lake City Community College |
| 26 | 765 | June-Reg | Alex Crooks | | 1B | 20 | 6/28/1984 | 6-2 | 235 | L | L | Rookie | | East Los Angeles Junior College |
| 27 | 795** | June-Reg | Matt Goyen | | P | 21 | 1/19/1983 | 6-5 | 220 | R | L | A+ | | Georgia College & State University |
| 28 | 825 | June-Reg | Nick Wagner | | P | 21 | 6/16/1983 | 6-2 | 220 | R | R | A | | Georgia Tech |
| 29 | 855** | June-Reg | Daniel McCutchen | | P | 21 | 9/26/1982 | 6-1 | 195 | R | R | AAA | | University of Oklahoma |
| 30 | 885 | June-Reg | Aaron Walker | | P | 22 | 2/4/1982 | 6-3 | 198 | L | L | A+ | | Georgia Tech |
| 31 | 915 | June-Reg | John Rodriguez | | P | | | | | | | - | | Pearl River Community College |
| 32 | 945 | June-Reg | Matt Rainey | | P | 20 | 4/21/1984 | 6-0 | 200 | R | R | A- | | Odessa College |
| 33 | 975 | June-Reg | Patrick Cottrell | | SS | 22 | 3/16/1982 | 5-11 | 160 | R | R | AA | | University of West Florida |
| 34 | 1005 | June-Reg | Grant Theophilus | | P | 19 | 4/22/1985 | | | L | L | College | | Cypress College |
| 35 | 1035 | June-Reg | Billy Evers | | P | 21 | 8/31/1982 | 6-2 | 195 | R | R | A | | Eckerd College |
| 36 | 1065 | June-Reg | Ryan Davis | | 3B | | | | | | | - | | Chaparral High School (Scottsdale,AZ) |
| 37 | 1095 | June-Reg | Brian McCormick | | C | | | | | | | - | | Arundel High School (Gambrills,MD) |
| 38 | 1125 | June-Reg | Ryan Conan | | SS | | | | | | | College | | Archbishop Mitty High School (San Jose,CA) |
| 39 | 1155 | June-Reg | Drew Bigda | | P | 21 | 5/16/1983 | 6-0 | 220 | R | L | A | | College of the Holy Cross |
| 40 | 1185 | June-Reg | Jason Dean | | OF | 19 | 12/16/1984 | 5-11 | 171 | R | R | - | | Sacramento City College |
| 41 | 1215 | June-Reg | J.T. Hall | | OF | 20 | 5/19/1984 | 6-3 | 210 | L | R | AAA | | Southwest (Miss) Junior College. |
| 42 | 1244 | June-Reg | Matt Ware | | P | | | | | | | - | | Quartz Hill High School (Quartz Hill,CA) |
| 43 | 1273 | June-Reg | John Price | | P | 22 | 7/10/1981 | 6-2 | 220 | R | L | A- | | University of Mobile |
| 44 | 1302 | June-Reg | Matt Fields | | 1B | 18 | 7/8/1985 | 6-4 | 255 | R | R | A+ | | Rainier Beach High School (Seattle,WA) |
| 45 | 1331 | June-Reg | John Bouman | | SS | 21 | 8/30/1982 | 6-4 | 190 | R | R | A+ | | Tusculum College |
| 46 | 1360 | June-Reg | Chris Kelly | | P | 21 | 7/14/1982 | 6-3 | 200 | R | R | A+ | | Jacksonville University |
| 47 | 1389 | June-Reg | Ben Lanier | | SS | | | | | | | - | | Kinston High School (Kinston,NC) |
| 48 | 1418 | June-Reg | Andrew Gray | | 1B | | | | | | | - | | Holy Spirit High School (Tuscaloosa,AL) |
| 49 | 1446 | June-Reg | Patrick Mahoney | | C | | | | | | | - | | Lincoln High School (Des Moines,IA) |
| 50 | 1474 | June-Reg | Jerrylee Scott | | SS | | | | | | | - | | Livonia High School (Livonia,LA) |
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