| Year | Rnd | Ovl | Phase | Player | Drafting Team | Pos | HiLvl | Played | Src | Drafted From | SF | State | AB | 2B | 3B | HR | RBI | SB | BAVG | W | L | ERA | SV | IP | SO | GS |
| 2010 | 1 | 44 | June-Reg | Nick Castellanos | Detroit Tigers | 3B | AAA | 2010-2013 | H | Archbishop McCarthy (Fort Lauderdale,FL) | SF | FL | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 1 | 48 | June-Reg | Chance Ruffin | Detroit Tigers | P | MLB | 2008-2013 | C | University of Texas | SF | TX | -- | -- | -- | -- | -- | -- | -- | 1 | 0 | 4.08 | 0 | 18 | 18 | 0 |
| 2010 | 2 | 68 | June-Reg | Drew Smyly | Detroit Tigers | P | MLB | 2009-2013 | C | University of Arkansas | SF | AR | 1 | 0 | 0 | 0 | 0 | 0 | .000 | 4 | 3 | 3.99 | 0 | 99 | 94 | 18 |
| 2010 | 3 | 100 | June-Reg | Rob Brantly | Detroit Tigers | C | MLB | 2009-2013 | C | University of California-Riverside | SF | CA | 100 | 8 | 0 | 3 | 8 | 1 | .290 | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 4 | 133 | June-Reg | Cole Green ** | Detroit Tigers | P | A | 2008-2012 | C | University of Texas | SF | TX | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 5 | 163 | June-Reg | Alexander Burgos | Detroit Tigers | P | A+ | 2010-2013 | C | State College of Florida, Manatee-Sarasota | SF | FL | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 6 | 193 | June-Reg | Bryan Holaday | Detroit Tigers | C | MLB | 2008-2013 | C | Texas Christian University | SF | TX | 12 | 1 | 0 | 0 | 0 | 0 | .250 | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 7 | 223 | June-Reg | Corey Jones | Detroit Tigers | 2B | AA | 2007-2013 | C | Cal State Fullerton | SF | CA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 8 | 253 | June-Reg | Patrick Leyland | Detroit Tigers | C | A+ | 2010-2013 | H | Bishop Canevin Catholic (Pittsburgh,PA) | SF | PA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 9 | 283 | June-Reg | Tony Plagman | Detroit Tigers | 1B | AA | 2007-2012 | C | Georgia Tech | SF | GA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 10 | 313 | June-Reg | Cole Nelson | Detroit Tigers | P | A+ | 2010-2012 | C | Auburn University | SF | AL | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 11 | 343 | June-Reg | Brian Dupra ** | Detroit Tigers | P | A | 2008-2013 | C | University of Notre Dame | SF | IN | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 12 | 373 | June-Reg | Kyle Ryan | Detroit Tigers | P | A+ | 2010-2013 | H | Auburndale (Auburndale,FL) | SF | FL | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 13 | 403 | June-Reg | P.J. Polk | Detroit Tigers | LF | A | 2008-2011 | C | University of Tennessee | SF | TN | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 14 | 433 | June-Reg | Patrick Cooper | Detroit Tigers | P | AA | 2010-2013 | C | Bradley University | SF | IL | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 15 | 463 | June-Reg | Collin Kuhn ** | Detroit Tigers | LF | A | 2009-2012 | C | University of Arkansas | SF | AR | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 16 | 493 | June-Reg | Jordan Pratt | Detroit Tigers | P | A+ | 2010-2011 | C | University of Arkansas | SF | AR | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 17 | 523 | June-Reg | Drew Gagnier | Detroit Tigers | P | A+ | 2007-2012 | C | University of Oregon | SF | OR | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 19 | 583 | June-Reg | Jeff Rowland | Detroit Tigers | OF | A | 2008-2011 | C | Georgia Tech | SF | GA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 20 | 613 | June-Reg | Tyler White | Detroit Tigers | P | A+ | 2009-2012 | C | University of Alabama | SF | AL | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 21 | 643 | June-Reg | James Meador | Detroit Tigers | 1B | A+ | 2007-2011 | C | University of San Diego | SF | CA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 22 | 673 | June-Reg | Jake Hernandez | Detroit Tigers | C | NCAA | 2011-2012 | H | Los Osos (Rancho Cucamonga,CA) | SF | CA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 23 | 703 | June-Reg | Dominic Ficociello | Detroit Tigers | SS | NCAA | 2011-2011 | H | Fullerton (Fullerton,CA) | SF | CA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 24 | 733 | June-Reg | Tyler Clark | Detroit Tigers | P | AA | 2008-2013 | C | University of Missouri | SF | MO | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 25 | 763 | June-Reg | Shawn Teufel | Detroit Tigers | P | AAA | 2006-2013 | C | Liberty University | SF | VA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 26 | 793 | June-Reg | Jeff Ferrell | Detroit Tigers | P | A+ | 2010-2013 | C | Pitt Community College | SF | NC | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 27 | 823 | June-Reg | Les Smith | Detroit Tigers | RF | A- | 2009-2011 | C | St. Louis Community College-Meramec | SF | MO | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 28 | 853 | June-Reg | Jack Duffey | Detroit Tigers | P | A- | 2010-2012 | H | Heritage (Conyers,GA) | SF | GA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 29 | 883 | June-Reg | Chris Joyce ** | Detroit Tigers | P | A+ | 2010-2012 | C | Central Arizona College | SF | AZ | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 30 | 913 | June-Reg | Logan Hoch | Detroit Tigers | P | A | 2008-2011 | C | Wichita State University | SF | KS | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 31 | 943 | June-Reg | Matt Little | Detroit Tigers | P | AA | 2007-2012 | C | University of Kentucky | SF | KY | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 32 | 973 | June-Reg | Clay Jones | Detroit Tigers | 1B | A | 2009-2011 | C | University of Alabama | SF | AL | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 33 | 1003 | June-Reg | Brennan Smith | Detroit Tigers | P | A | 2008-2013 | C | Bowling Green State University | SF | OH | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 34 | 1033 | June-Reg | Nolan Sanburn ** | Detroit Tigers | OF | A- | 2011-2012 | H | Kokomo (Kokomo,IN) | SF | IN | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 35 | 1063 | June-Reg | Cody Hall ** | Detroit Tigers | P | A+ | 2010-2013 | C | Southern University | SF | LA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 36 | 1093 | June-Reg | Ryan Soares | Detroit Tigers | SS | A+ | 2007-2012 | C | George Mason University | SF | VA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 37 | 1123 | June-Reg | Carlos Lopez | Detroit Tigers | 1B | NCAA | 2010-2012 | C | Cal State Fullerton | SF | CA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 38 | 1153 | June-Reg | Jake Dziubczynksi | Detroit Tigers | P | NCAA | 2010-2012 | C | Central Arizona College | SF | AZ | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 39 | 1183 | June-Reg | Bo McClendon | Detroit Tigers | LF | A- | 2007-2011 | C | Valparaiso University | SF | IN | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 40 | 1213 | June-Reg | Pete Miller | Detroit Tigers | SS | RK | 2010-2010 | C | Trinity International University | SF | IL | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 41 | 1243 | June-Reg | Matt Perry | Detroit Tigers | 3B | A+ | 2007-2013 | C | College of the Holy Cross | SF | MA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 42 | 1273 | June-Reg | Kevin Grant | Detroit Tigers | OF | - | H | Millard West (Omaha,NE) | SF | NE | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | |
| 2010 | 43 | 1303 | June-Reg | Blake Bell | Detroit Tigers | P | - | H | Bishop Carroll Catholic (Wichita,KS) | SF | KS | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | |
| 2010 | 44 | 1333 | June-Reg | Ricky Knapp | Detroit Tigers | P | NCAA | 2011-2012 | H | Port Charlotte (Port Charlotte,FL) | SF | FL | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 45 | 1363 | June-Reg | Jacob Morton | Detroit Tigers | C | NCAA | 2011-2012 | H | Hudsonville (Hudsonville,MI) | SF | MI | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 46 | 1393 | June-Reg | Ben Verlander | Detroit Tigers | P | NCAA | 2011-2012 | H | Goochland (Goochland,VA) | SF | VA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 47 | 1423 | June-Reg | Christopher Triplett | Detroit Tigers | SS | NCAA | 2011-2011 | H | Sandy Creek (Tyrone,GA) | SF | GA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 48 | 1453 | June-Reg | Tyler Marincov | Detroit Tigers | OF | NCAA | 2011-2012 | H | Timber Creek (Orlando,FL) | SF | FL | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 49 | 1483 | June-Reg | Tyson Kendrick | Detroit Tigers | C | AA | 2010-2010 | C | Tabor College | SF | KS | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010 | 50 | 1513 | June-Reg | Jake Ross | Detroit Tigers | P | - | C | Wor-Wic Community College | SF | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |