| 485. | Josh Johnson | P | TB | 22 | 10/6/1984 | 6-0 | | R-R | College | | Mississippi State University | 142 |
| 489. | Tyler Kolodny | 3B | BAL | 19 | 3/9/1988 | 6-2 | 225 | R-R | Rookie | | El Camino Real High School (Woodland Hills,CA) | 13 |
| 490. | Chris Blackwood | OF | WAN | 19 | 11/23/1987 | 6-2 | 165 | L-R | Rookie | | Gloucester County College | 18 |
| 495. | Colin Buckborough | P | SEA | 18 | 4/6/1989 | 6-5 | 183 | R-R | - | | Stamford Collegiate High School (Niagara Falls,ON) | |
| 496. | Adam Campbell | P | FLA | 22 | 9/21/1984 | 6-2 | 225 | R-R | A+ | | University of New Orleans | 76 |
| 499. | Shea Snowden | P | CIN | 18 | 10/6/1988 | 6-1 | 150 | L-L | Rookie | | Brandon High School (Brandon,MS) | 1 |
| 500. | Josh Lueke | P | TEX | 22 | 12/5/1984 | 6-5 | 220 | R-R | A+ | | Northern Kentucky University | 18 |
| 501. | Devon Torrence | OF | HOU | 18 | 5/8/1989 | 6-0 | 190 | R-R | Rookie | | Canton South High School (Canton,OH) | 2 |
| 505. | Darin Mastroianni | 2B | TOR | 21 | 8/26/1985 | 5-11 | 190 | R-R | A | | University of Southern Indiana | 3 |
| 506. | Andres Santiago | P | LA | 17 | 10/26/1989 | 6-2 | 200 | R-R | Rookie | | Colegio Carmen Sol High School (Bayamon,PR) | |
| 507. | Robert Perry | OF | SD | 22 | 10/3/1984 | 5-9 | 190 | L-L | A+ | | Long Beach State University | 155 |
| 508. | Mason Tobin | P | LAA | 19 | 7/8/1987 | 6-3 | 210 | R-R | A | | Everett Community College (WA) | 12 |
| 509. | Nick Mahin | OF | CHW | 21 | 8/19/1985 | 6-1 | 225 | R-R | Rookie | | California State University, Fullerton | 238 |
| 511. | Mark Brackman | P | DET | 22 | 3/23/1985 | 6-7 | 220 | R-R | A+ | | William Jewell College (Mo.) | 6 |