| 1 | 13 | June-Reg | Tyler Colvin | LF | 20 | 6-3 | 190 | L | L | MLB | 2009-2009 | Clemson University | $1,475,000 |
| 5 | 149 | June-Reg | Jeff Samardzija | P | 21 | 6-5 | 215 | R | R | MLB | 2008-2009 | University of Notre Dame | $1,000,000 |
| 6 | 179 | June-Reg | Josh Lansford | 3B | 21 | 6-2 | 220 | R | R | AA | | Cal Poly | $155,000 |
| 7 | 209 | June-Reg | Steve Clevenger | SS | 20 | 6-0 | 185 | L | R | AAA | | Chipola College | $130,000 |
| 8 | 239 | June-Reg | Billy Muldowney | P | 21 | 6-1 | 225 | R | R | A+ | | University of Pittsburgh | $98,500 |
| 9 | 269 | June-Reg | Cliff Andersen | CF | 18 | 6-2 | 185 | L | L | A | | Cottonwood (Salt Lake City,UT) | $155,000 |
| 10 | 299 | June-Reg | Jake Renshaw | P | 20 | 6-3 | 215 | R | R | A+ | | Ventura College | $60,000 |
| 11 | 329 | June-Reg | Chris Huseby | P | 18 | 6-7 | 225 | R | R | A | | Martin County (Stuart,FL) | $1,300,000 |
| 12 | 359 | June-Reg | Kitt Kopach | P | 21 | 6-1 | 200 | L | R | A- | | Illinois State University | |
| 13 | 389 | June-Reg | Matt Camp | CF | 22 | 6-0 | 175 | L | R | AAA | | North Carolina State University | |
| 14 | 419 | June-Reg | Andrew Rundle | CF | 18 | 6-4 | 180 | L | L | A+ | | Bend (Bend,OR) | |
| 15 | 449 | June-Reg | Matt Canepa | C | 21 | 6-1 | 195 | R | R | A | | Cal Poly | |
| 16 | 479 | June-Reg | Blake Parker | C | 21 | 6-3 | 200 | R | R | AAA | | University of Arkansas | |
| 17 | 509 | June-Reg | Keoni Ruth | 2B | 21 | 5-11 | 200 | R | R | AAA | | University of San Diego | |
| 18 | 539 | June-Reg | Jose Hernandez | P | 18 | 6-2 | 190 | R | R | - | | Edgewater (Orlando,FL) | |
| 19 | 569 | June-Reg | Jeremy Papelbon | P | 23 | 6-1 | 205 | L | L | AAA | | University of North Florida | |
| 20 | 599 | June-Reg | Kevin Kreier | P | 18 | 6-4 | 205 | R | R | A | | Foothill (Henderson,NV) | |
| 21 | 629 | June-Reg | Taylor Parker | P | 21 | 5-10 | 147 | L | L | Rookie | | University of Missouri | |
| 22 | 659 | June-Reg | Jovan Rosa | 3B | 18 | 6-2 | 180 | R | R | A+ | | Lake City Community College | $180,000 |
| 23 | 689 | June-Reg | Chuckie Platt | P | 23 | 6-2 | 235 | R | R | A+ | | Lamar University | |
| 24 | 719 | June-Reg | Matt Matulia | SS | 22 | 5-11 | 195 | B | R | AAA | | The Citadel | |
| 25 | 749 | June-Reg | Jamie Bagley | P | 18 | 6-3 | 205 | R | R | A | | Hargrave (Huffman,TX) | |
| 26 | 779 | June-Reg | Michael Cooper | P | 22 | 6-6 | 230 | R | R | AA | | University of California | |
| 27 | 809 | June-Reg | Cedric Redmond | P | 17 | 6-1 | 175 | R | L | AAA | | Joliet Township (Joliet Township,IL) | |
| 28 | 839 | June-Reg | Brett Summers | P | 19 | 6-6 | 185 | R | R | - | | South Suburban College | |
| 29 | 869 | June-Reg | Jordan Latham | P | 19 | 6-1 | 180 | R | R | A+ | | College of Southern Idaho | |
| 30 | 899 | June-Reg | Donald Walters | P | 19 | 6-1 | 195 | R | R | A+ | | Richland College | |
| 31 | 929 | June-Reg | Bryan Collins | P | 21 | 6-1 | 210 | R | R | A- | | Alvin Community College | |
| 32 | 959 | June-Reg | Cesar Valentin | SS | 17 | 5-11 | 155 | R | R | Rookie | | Catalina Morales de Flore (Moca,PR) | |
| 33 | 989 | June-Reg | Brad Clipp | P | 21 | 6-3 | 185 | R | R | A+ | | Point Loma Nazarene University | |
| 34 | 1019 | June-Reg | Nathan Samson | SS | 18 | 6-0 | 170 | R | R | AAA | | Forest (Ocala,FL) | $155,000 |
| 35 | 1049** | June-Reg | Marquez Smith | 3B | 21 | 5-10 | 200 | R | R | AA | | Clemson University | $0 |
| 36 | 1079 | June-Reg | Miguel Cuevas-Novas | P | 22 | 6-9 | 275 | R | R | A+ | | Los Angeles Pierce College | |
| 37 | 1109 | June-Reg | David Francis | P | 18 | 6-2 | 200 | R | R | A+ | | St. Joseph SS (Mississauga,ON) | |
| 38 | 1139 | June-Reg | Ben Feltner | CF | 20 | 5-11 | 185 | B | R | College | | Temple College | |
| 39 | 1169 | June-Reg | Marcus Hatley | CF | 18 | 6-4 | 190 | R | R | A | | Mission Hills (San Marcos,CA) | |
| 40 | 1199 | June-Reg | Eli Diaz | P | 19 | 6-3 | 180 | R | R | Ind | | Texarkana College | |
| 41 | 1229 | June-Reg | Jonathan Negron | P | 17 | 6-3 | 182 | R | R | - | | Puerto Rico Baseball Academy (Gurabo,PR) | |
| 42 | 1259 | June-Reg | Benjamin Ornelas | OF | 19 | 6-2 | 210 | B | R | - | | Cypress College | |
| 43 | 1288 | June-Reg | Anthony Morel | SS | 18 | 6-1 | 175 | R | R | College | | Riverside Community College | |
| 44 | 1317 | June-Reg | Daniel Berlind | P | 18 | 6-7 | 210 | R | R | A | | Calabasas (Calabasas,CA) | |
| 45 | 1346 | June-Reg | Elliott Shea | CF | 22 | 6-0 | 200 | R | R | Ind | | Franklin Pierce University | |
| 46 | 1375 | June-Reg | Ryan Shook | P | 17 | 5-11 | 170 | L | L | - | | Valley Christian (Cerritos,CA) | |
| 47 | 1403 | June-Reg | Andrew McCormick | P | 21 | 6-6 | 210 | R | R | A- | | Pikeville College | |
| 48 | 1431 | June-Reg | Kenneth Goodline | P | 17 | 6-4 | 170 | R | R | - | | North Monterey (Castroville,CA) | |
| 49 | 1459 | June-Reg | Ryne Malone | 3B | 21 | 5-11 | 180 | L | R | A+ | | Florida State University | |
| 50 | 1487 | June-Reg | Ryan Davis | P | 18 | 6-2 | 170 | L | L | - | | East Lake (Sammamish,WA) | |