| 1 | 7 | June-Reg | Troy Tulowitzki | ss | 20 | 6-3 | 205 | R | R | MLB | 2006-2009 | Long Beach State University | $2,300,000 |
| 1 | 32 | June-Reg | Chaz Roe | P | 18 | 6-5 | 180 | R | R | AA | | Lafayette (Lexington,KY) | $1,025,000 |
| 2 | 52 | June-Reg | Daniel Carte | of | 21 | 6-0 | 190 | R | R | AA | | Winthrop University | $670,000 |
| 2 | 55 | June-Reg | Zach Simons | P | 20 | 6-3 | 180 | L | R | AAA | | Everett Community College | $635,000 |
| 3 | 87 | June-Reg | Kyle Hancock | P | 17 | 6-3 | 185 | R | R | Rookie | | Rowlett (Rowlett,TX) | $475,000 |
| 4 | 117 | June-Reg | Brandon Durden | P | 20 | 6-3 | 215 | R | L | AA | | Georgia College & State University | $275,000 |
| 5 | 147 | June-Reg | Josh Sullivan | P | 20 | 6-4 | 205 | R | R | A | | Auburn University | $180,000 |
| 6 | 177 | June-Reg | Corey Wimberly | 2b | 21 | 5-8 | 180 | B | R | AA | | Alcorn State University | $145,000 |
| 7 | 207 | June-Reg | Geoff Strickland | SS | 20 | 5-10 | 180 | B | R | A+ | | Florida Southern College | $115,000 |
| 8 | 237 | June-Reg | James Burok | P | 22 | 6-3 | 212 | R | R | A+ | | Old Dominion University | $12,000 |
| 9 | 267 | June-Reg | Andrew Johnston | P | 21 | 6-5 | 205 | R | R | AA | | University of Missouri | $72,500 |
| 10 | 297 | June-Reg | Garner Wetzel | SS | 21 | 6-2 | 210 | R | R | A- | | Millsaps College | $58,000 |
| 11 | 327 | June-Reg | Chris Frey | of | 21 | 6-1 | 180 | L | L | AAA | | University of Arizona | |
| 12 | 357 | June-Reg | Dominick Foster | P | 19 | | | | | - | | Fresno City College | |
| 13 | 387 | June-Reg | Michael Paulk | of | 21 | 6-1 | 195 | L | L | AAA | | Cal State Northridge | |
| 14 | 417 | June-Reg | Kyle Blumenthal | C | 22 | 5-10 | 187 | L | R | A+ | | Cal Poly | |
| 15 | 447 | June-Reg | Travis Becktel | OF | 22 | 6-1 | 201 | R | R | A+ | | San Jose State University | |
| 16 | 477 | June-Reg | Bret Beglund | of | 22 | 6-4 | 210 | R | R | - | | Cal Poly | |
| 17 | 507 | June-Reg | Jason Freeman | P | 22 | 5-9 | 161 | L | R | College | | Washington State University | |
| 18 | 537 | June-Reg | Brett Strickland | P | 22 | 6-0 | 170 | R | R | A+ | | Georgia State University | |
| 19 | 567 | June-Reg | Byron Binda | P | 22 | 6-0 | 185 | R | R | A | | Coastal Carolina University | |
| 20 | 597 | June-Reg | Andy Kreidermacher | P | 22 | 6-2 | 195 | B | R | A+ | | Minnesota State University-Mankato | |
| 21 | 627 | June-Reg | Chris Martin | P | 19 | 6-7 | 175 | R | R | - | | McLennan Community College | |
| 22 | 657 | June-Reg | Radames Nazario | ss | 18 | 6-0 | 166 | R | R | AAA | | Pimentel (Naguabo,PR) | |
| 23 | 687 | June-Reg | Phil Cuadrado | 3b | 21 | 6-1 | 210 | B | R | A+ | | Cumberland University | |
| 24 | 717 | June-Reg | Sean Toler | P | 18 | 6-4 | 200 | R | R | College | | Parkway South (Manchester,MO) | |
| 25 | 747 | June-Reg | Steven Hirschfeld | P | 19 | 6-5 | 220 | R | R | A+ | | College of Southern Nevada | |
| 26 | 777 | June-Reg | Ethan Katz | P | 21 | 6-5 | 210 | R | R | A | | Sacramento State | |
| 27 | 807 | June-Reg | Sean Ruthven | P | 22 | 6-4 | 170 | R | R | A- | | University of Georgia | |
| 28 | 837 | June-Reg | David Bechtold | P | 22 | 6-2 | 190 | L | L | A- | | Liberty University | |
| 29 | 867** | June-Reg | Reese Havens | SS | 18 | 6-1 | 195 | L | R | A+ | | Bishop England (Charleston,SC) | $0 |
| 30 | 897 | June-Reg | Mike Milliron | ss | 22 | 6-0 | 175 | R | R | A- | | Penn State University | |
| 31 | 927** | June-Reg | Sean Halton | 1b | 18 | 6-5 | 235 | R | R | Rookie | | Fresno (Fresno,CA) | |
| 32 | 957** | June-Reg | Jarrad Page | OF | 20 | 6-0 | 200 | B | R | College | | UCLA | |
| 33 | 987 | June-Reg | Jordan Jarvis | P | 18 | 6-3 | 205 | R | R | - | | Arcadia (Phoenix,AZ) | |
| 34 | 1017 | June-Reg | Kyle Beitey | P | 19 | 6-4 | 225 | L | L | - | | Lower Columbia Community College | |
| 35 | 1047 | June-Reg | Tim Brewer | P | 17 | 6-3 | 187 | L | L | - | | Ivanna Eudora Kean (St. Thomas,Virgin Islands) | |
| 36 | 1077 | June-Reg | Chris Cook | 1b | 21 | 6-4 | 222 | R | R | A+ | | Grand Canyon University | |
| 37 | 1107 | June-Reg | C.J. Belanger | OF | 18 | 6-3 | 200 | L | R | College | | Cypress (Cypress,CA) | |
| 38 | 1137 | June-Reg | Barret Browning | P | 20 | 6-1 | 170 | L | L | AA | | Florida State University | |
| 39 | 1167 | June-Reg | Rod Scurry | P | 19 | 6-7 | 190 | R | R | A- | | Sierra College | |
| 40 | 1196 | June-Reg | Joseph Servais | C | 19 | 5-11 | 180 | R | R | College | | Garden City Community College | |
| 41 | 1225 | June-Reg | Jeremy Farrell | 3b | 18 | 6-3 | 200 | R | R | A | | St. Ignatius (Cleveland,OH) | |
| 42 | 1254 | June-Reg | Maikol Gonzales | SS | 19 | 5-9 | 170 | R | R | - | | Louisburg College | |
| 43 | 1283** | June-Reg | Jordan Rogers | P | 18 | 6-2 | 190 | R | R | College | | Dayton (Dayton,TX) | |
| 44 | 1312 | June-Reg | Phillip Myers | P | 18 | 6-5 | 210 | R | L | College | | Ballard (Louisville,KY) | |
| 45 | 1341 | June-Reg | Chris Bell | OF | 18 | 6-2 | 180 | L | R | - | | Johnson (Gainesville,GA) | |
| 46 | 1370 | June-Reg | Garrett Vaughan | C | 18 | 6-3 | 185 | R | R | - | | Sibley (La. ) | |
| 47 | 1399 | June-Reg | Brent Weiss | 2b | 18 | 6-0 | 175 | R | R | College | | St. Joseph Regional (Montvale,NJ) | |
| 48 | 1427 | June-Reg | Spencer Schuh | P | 18 | 6-2 | 185 | R | R | - | | Harrison (Harrison,AR) | |
| 49 | 1454 | June-Reg | Jordan Moore | P | 19 | 6-4 | 195 | L | L | - | | Spokane Falls Community College | |
| 50 | 1481 | June-Reg | James Pollack | C | 18 | 6-1 | 215 | R | R | - | | North Broward Prep (Parkland,FL) | |