| 254. | Mike Carp | 1B | NYM | 18 | 6/30/1986 | 6-2 | 205 | L-R | AA | | Lakewood High School (Lakewood,CA) | 46 |
| 255. | Joseph Muro | P | TB | 20 | 2/16/1984 | 6-0 | 161 | R-R | A- | | Mount San Antonio College | 125 |
| 256. | Derek De Carlo | P | MIL | 21 | 3/24/1983 | 6-3 | 170 | R-R | A | | Florida International University | 97 |
| 259. | Joey Howell | OF | BAL | 18 | 9/22/1985 | 6-1 | 205 | R-R | A | | Santaluces High School (Lantana,FL) | 5 |
| 262. | Christopher Covington | OF | PIT | 18 | 12/12/1985 | 5-11 | 190 | R-R | Rookie | | Brookwood High School (Snellville,GA) | 3 |
| 264. | Brandon Conway | SS | MTL | 20 | 11/9/1983 | 6-3 | 190 | L-R | A- | | Frederick Community College | 9 |
| 265. | Chris McConnell | SS | KC | 18 | 12/18/1985 | 5-11 | 170 | R-R | A+ | | Delsea High School (Franklinville,NJ) | 2 |
| 266. | A.J. Shappi | P | ARI | 21 | 10/16/1982 | 6-2 | 200 | R-R | AAA | | University of California-Riverside | 77 |
| 271. | J.P. Martinez | P | MIN | 22 | 6/8/1982 | 6-2 | 205 | R-R | AAA | | University of New Orleans | 73 |
| 272. | Andy Macfarlane | OF | PHI | 20 | 8/18/1983 | 5-11 | 190 | R-L | A- | | Treasure Valley Community College | 37 |
| 274. | Troy Patton | P | HOU | 18 | 9/3/1985 | 6-1 | 185 | B-L | MLB | 2007-2007 | Tomball High School (Tomball,TX) | 5 |
| 277. | Chad Boyd | OF | OAK | 19 | 4/21/1985 | 5-10 | 180 | L-L | A+ | | El Camino Real High School (Woodland Hills,CA) | 12 |
| 278. | Joe Pietro | OF | FLA | 21 | 12/13/1982 | 6-0 | 190 | L-R | A | | University of New Orleans | 74 |
| 281. | Jeff Katz | P | ATL | 18 | 4/18/1986 | 6-4 | 217 | R-R | Rookie | | Cheshire High School (Cheshire,CT) | 5 |