| 42. | Brett Smith | P | NYY | 20 | 8/12/1983 | 6-5 | 220 | R-R | AA | | University of California-Irvine | 36 |
| 44. | Matt Durkin | P | NYM | 21 | 2/22/1983 | 6-4 | 220 | R-R | A | | San Jose State University | 78 |
| 45. | Reid Brignac | SS | TB | 18 | 1/16/1986 | 6-3 | 170 | L-R | AAA | | St. Amant High School (St. Amant,LA) | 6 |
| 46. | Yovani Gallardo | P | MIL | 18 | 2/27/1986 | 6-2 | 190 | R-R | MLB | 2007-2008 | Trimble Tech High School (Fort Worth,TX) | 2 |
| 49. | Michael Rogers | P | OAK | 21 | 10/24/1982 | 6-1 | 195 | R-R | AA | | North Carolina State University | 86 |
| 50. | Seth Smith | OF | COL | 21 | 9/30/1982 | 6-3 | 215 | L-L | MLB | 2007-2008 | University of Mississippi | 91 |
| 51. | K.C. Herren | OF | TEX | 18 | 8/21/1985 | 6-0 | 210 | L-R | A+ | | Auburn High School (Auburn,WA) | 3 |
| 52. | Brian Bixler | SS | PIT | 21 | 10/22/1982 | 6-1 | 188 | R-R | MLB | 2008-2008 | Eastern Michigan University | 68 |
| 54. | Erick San Pedro | C | MTL | 20 | 10/5/1983 | 6-0 | 205 | R-R | AAA | | University of Miami (Florida) | 185 |
| 55. | Billy Buckner | P | KC | 20 | 8/27/1983 | 6-2 | 195 | R-R | MLB | 2007-2007 | University of South Carolina | 112 |
| 56. | Jon Zeringue | OF | ARI | 21 | 3/29/1983 | 6-2 | 215 | R-R | AA | | Louisiana State University | 138 |
| 61. | Anthony Swarzak | P | MIN | 18 | 9/10/1985 | 6-3 | 195 | R-R | AA | | Nova High School (Davie,FL) | 7 |
| 62. | Jason Jaramillo | C | PHI | 21 | 10/9/1982 | 6-0 | 200 | B-R | AAA | | Oklahoma State University | 172 |
| 64. | Hunter Pence | OF | HOU | 21 | 4/13/1983 | 6-4 | 210 | R-R | MLB | 2007-2008 | University of Texas-Arlington | 27 |
| 67. | Kurt Suzuki | C | OAK | 20 | 10/4/1983 | 5-11 | 200 | R-R | MLB | 2007-2008 | California State University, Fullerton | 205 |
| 68. | Jason Vargas | P | FLA | 21 | 2/2/1983 | 6-0 | 215 | L-L | MLB | 2005-2007 | Long Beach State University | 136 |
| 69. | Ray Liotta | P | CHW | 21 | 4/3/1983 | 6-3 | 220 | L-L | AA | | Gulf Coast Community College | 145 |