| 403. | James Skelton | C | DET | 18 | 10/28/1985 | 5-11 | 165 | L-R | A+ | | West Covina High School (West Covina,CA) | 19 |
| 404. | Brad Meyers | P | NYM | 18 | 9/13/1985 | 6-6 | 195 | R-R | A+ | | Servite High School (Anaheim,CA) | 17 |
| 405. | Woods Fines | P | TB | 18 | 8/14/1985 | 6-5 | 190 | R-R | A | | Northwood High School (Pittsboro,NC) | 1 |
| 406. | Grant Richardson | 3B | MIL | 21 | 2/26/1983 | 6-1 | 210 | R-R | A | | Washington State University | 120 |
| 409. | Kyle Schmidt | P | BAL | 20 | 8/25/1983 | 6-3 | 220 | R-R | AA | | University of South Florida | 82 |
| 410. | Dexter Fowler | OF | COL | 18 | 3/22/1986 | 6-5 | 189 | B-R | AA | | Milton High School (Alpharetta,GA) | 4 |
| 412. | Jermel Lomack | 2B | PIT | 21 | 5/13/1983 | 5-8 | 160 | B-R | A | | Prairie View A&M University | 9 |
| 413. | Nick Adenhart | P | ANA | 17 | 8/24/1986 | 6-4 | 190 | R-R | MLB | 2008-2008 | Williamsport High School (Williamsport,MD) | 2 |
| 417. | Jordan Timm | P | TOR | 23 | 1/15/1981 | 6-6 | 230 | L-L | A+ | | University of Wisconsin, Oshkosh | 28 |
| 425. | R.J. Swindle | P | BOS | 20 | 7/7/1983 | 6-3 | 195 | L-L | AAA | | Charleston Southern University | 2 |
| 429. | Ben Jones | 1B | NYY | 22 | 7/3/1981 | 6-3 | 196 | R-R | A+ | | University of Louisiana-Monroe | 7 |
| 430. | Geno Espineli | P | SF | 21 | 9/8/1982 | 6-4 | 195 | L-L | AAA | | Texas Christian University | 72 |